National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1156

TDMS Study 05123-05 Pathology Tables

NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20

                                                          Core Animals




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  001313991

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/M3
                               Include 002    0 MG/M3
                               Include 005    0.62MGM3
                               Include 006    0.62MGM3
                               Include 009    1.25MGM3
                               Include 010    1.25MGM3
                               Include 013    2.5MG/M3
                               Include 014    2.5MG/M3


























Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|             
                             DAY ON TEST   | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|             
                                           | 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X     X     X        X           X  X        X               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Odontoma                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                         +                                                |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Atrium, Leukemia Mononuclear         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |             X           X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X                                                |             
      Pheochromocytoma Benign              |                                  X           X                           |             
      Bilateral, Pheochromocytoma Benign   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Adenoma                              |                X                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X                                                |             
      Pars Distalis, Adenoma               |       X  X           X  X  X  X        X  X        X                 X  X|             
      Pars Distalis, Carcinoma             |                                                                X         |             
      Pars Distalis, Leukemia Mononuclear  | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|             
                             DAY ON TEST   | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|             
                                           | 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                                               +   |             
      Fibrosarcoma                         |                      X                                                   |             
      Osteosarcoma                         |                                                                          |             
      Squamous Cell Carcinoma              |                                                                      X   |             
      Oral, Squamous Cell Carcinoma        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                         X|             
      Carcinoma                            |    X                    X                                                |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa-Theca Tumor Benign         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |             X                    X                    X                 X|             
                                            __________________________________________________________________________|             
   Vagina                                  |                      +                                                   |             
      Polyp                                |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +        +     +              +     +                           |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                         X                                                |             
      Pancreatic, Leukemia Mononuclear     | X        X              X                    X                           |             
      Popliteal, Leukemia Mononuclear      |                                                                          |             
      Renal, Leukemia Mononuclear          |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +|             
      Leukemia Mononuclear                 |                   X     X                    X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X           X        X           X           X               |             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 | X        X  X           X                    X           X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |          X  X           X        X           X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X     X     X        X           X  X        X        X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                    X  X                        |             
      Thymoma NOS                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|             
                             DAY ON TEST   | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|             
                                           | 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
      Carcinoma, Multiple                  |                X                                                         |             
      Fibroadenoma                         |       X        X                    X                                   X|             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +                                                      |             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic                |                                                                X         |             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                                       |             
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |             
      Leukemia Mononuclear                 | X     X  X  X     X     X        X           X  X        X        X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X     X     X        X           X  X        X        X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|             
                                           | 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X              X     X     X  X                 X               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Odontoma                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                    +                                                |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Atrium, Leukemia Mononuclear         |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |    X                                                                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X     X                                          |             
      Pheochromocytoma Benign              |                                                          X               |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X        X        X                          X  X           X        X  X|             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|             
                                           | 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                             +              +      |             
      Fibrosarcoma                         |                                                                          |             
      Osteosarcoma                         |                      X                                                   |             
      Squamous Cell Carcinoma              |                                                                   X      |             
      Oral, Squamous Cell Carcinoma        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa-Theca Tumor Benign         |                                     X                                    |             
      Leukemia Mononuclear                 |                         X     X                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |             X                    X        X                    X  X      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
      Polyp                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +              +     +        +                                +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |          X                             X                                 |             
      Pancreatic, Leukemia Mononuclear     | X                             X        X                                 |             
      Popliteal, Leukemia Mononuclear      |                                                                          |             
      Renal, Leukemia Mononuclear          |                         X     X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X     X        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +  +  M  +  +  M  +  +  +|             
      Leukemia Mononuclear                 | X        X              X     X     X  X                                 |             
      Squamous Cell Carcinoma, Metastatic  |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X     X        X  X              X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X              X     X        X  X              X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X              X     X     X  X  X              X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Leukemia Mononuclear                 | X        X              X     X        X                 X               |             
      Thymoma NOS                          |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   6                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|             
                                           | 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma, Multiple                  |                                                                          |             
      Fibroadenoma                         |                   X        X     X                 X        X           X|             
      Fibroadenoma, Multiple               |    X                                                                     |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    |                +                 +              +                        |             
      Basal Cell Adenoma                   |                                                 X                        |             
      Keratoacanthoma                      |                X                                                         |             
      Squamous Cell Papilloma              |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic                |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Adrenal Cortex|    X                                                                     |             
      Leukemia Mononuclear                 | X     X  X              X     X        X                 X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Transitional Epithelium, Carcinoma   |                                                                X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X              X     X     X  X  X              X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   7                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 2| 8|                                                                 |            |
                                           | 2| 7| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0 MG/M3                                | 2| 2| 3|                                                                 |     L      |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X     X                                                                  |         20 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
      Odontoma                             |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   3        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
      Atrium, Leukemia Mononuclear         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pheochromocytoma Benign              |                                                                          |          3 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |    X                                                                     |         20 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 2| 8|                                                                 |            |
                                           | 2| 7| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0 MG/M3                                | 2| 2| 3|                                                                 |     L      |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   6        |
      Fibrosarcoma                         |                                                                          |          1 |
      Osteosarcoma                         |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          2 |
      Oral, Squamous Cell Carcinoma        |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Granulosa-Theca Tumor Benign         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Polyp Stromal                        |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
      Polyp                                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                                                                  |  14        |
      Axillary, Leukemia Mononuclear       | X                                                                        |          1 |
      Deep Cervical, Leukemia Mononuclear  | X                                                                        |          1 |
      Iliac, Leukemia Mononuclear          | X                                                                        |          4 |
      Pancreatic, Leukemia Mononuclear     | X     X                                                                  |          9 |
      Popliteal, Leukemia Mononuclear      | X                                                                        |          1 |
      Renal, Leukemia Mononuclear          | X     X                                                                  |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  49        |
      Leukemia Mononuclear                 | X     X                                                                  |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  47        |
      Leukemia Mononuclear                 | X                                                                        |         13 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 2| 8|                                                                 |            |
                                           | 2| 7| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0 MG/M3                                | 2| 2| 3|                                                                 |     L      |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +                                                                  |  51        |
      Leukemia Mononuclear                 | X     X                                                                  |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  48        |
      Leukemia Mononuclear                 | X     X                                                                  |         14 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X     X                                                                  |         22 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  48        |
      Leukemia Mononuclear                 | X                                                                        |         10 |
      Thymoma NOS                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma, Multiple                  |                                                                          |          1 |
      Fibroadenoma                         |    X                                                                     |         11 |
      Fibroadenoma, Multiple               |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   4        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         20 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 2| 8|                                                                 |            |
                                           | 2| 7| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0 MG/M3                                | 2| 2| 3|                                                                 |     L      |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X     X                                                                  |         22 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|             
                                           | 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                 X                        |             
      Leukemia Mononuclear                 |          X     X                                            X     X     X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma, Metastatic             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                                                         |             
      Pheochromocytoma Benign              |          X  X     X           X                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Osteosarcoma, Metastatic             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X              X           X  X  X  X     X        X           X      |             
      Pars Distalis, Carcinoma             | X                          X                                             |             
      Pars Distalis, Leukemia Mononuclear  |          X     X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Fibrous Histiocytoma                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|             
                                           | 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                       X           X      |             
      Bilateral, Adenoma                   |                         X                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +     +                                                         |             
      Leukemia Mononuclear                 |                                                                          |             
      Axillary, Leukemia Mononuclear       |                X                                                         |             
      Iliac, Leukemia Mononuclear          |                X                                                         |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  I  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |          X     X                                            X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                                            X           X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  I  +  +  +  M  M  +  M  +  +  +  +  +  M  +  M  +|             
      Leukemia Mononuclear                 |          X     X                                            X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |       X  X     X     X                                      X  X  X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                                            X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |          X                       X                 X  X        X     X   |             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                       +                  |             
      Hemangioma                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rib, Osteosarcoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  13                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|             
                                           | 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Carcinoma, Metastatic    | X                          X                                             |             
      Cerebrum, Carcinoma, Metastatic      | X                          X                                             |             
      Cerebrum, Osteosarcoma, Metastatic   |                                                                          |             
      Hypothalamus, Carcinoma, Metastatic  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X     X                                      X     X     X|             
      Osteosarcoma, Metastatic             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Mesenchymal Tumor NOS                |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X     X     X                                      X  X  X     X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|             
                                           | 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |                   X  X        X              X     X        X  X        X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma, Metastatic             |                X                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Osteosarcoma, Metastatic             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                            X     X     X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Osteosarcoma, Metastatic             |                X                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X  X                 X        X  X  X     X     X  X  X     X      |             
      Pars Distalis, Carcinoma             |             X                                                            |             
      Pars Distalis, Leukemia Mononuclear  |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
      Fibrous Histiocytoma                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  15                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|             
                                           | 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                           |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |             X                                                           X|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +                 +                     |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                               X                    X                     |             
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                    X        X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | I  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  I|             
      Leukemia Mononuclear                 |                   X  X        X  X                 X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X        X              X     X        X  X     X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                   X           X                    X        X  X        X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |       X                                                                  |             
      Leukemia Mononuclear                 |                   X  X        X  X           X     X        X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                    X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                           |             
      Fibroadenoma                         |    X                       X                    X     X     X            |             
      Fibroadenoma, Multiple               | X                                                        X           X   |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Skin                                    |                            +  +                                          |             
      Hemangioma                           |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rib, Osteosarcoma                    |                X                                                         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  16                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|             
                                           | 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Carcinoma, Metastatic    |                                                                          |             
      Cerebrum, Carcinoma, Metastatic      |             X                                                            |             
      Cerebrum, Osteosarcoma, Metastatic   |                X                                                         |             
      Hypothalamus, Carcinoma, Metastatic  |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X                             X           X  X      |             
      Osteosarcoma, Metastatic             |                X                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +              +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Mesenchymal Tumor NOS                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X        X  X           X     X        X  X  X  X  X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  17                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 0| 0| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.62MGM3                               | 5| 5| 5|                                                                 |     L      |
                                           | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         13 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  M                                                                  |  52        |
      Osteosarcoma, Metastatic             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Osteosarcoma, Metastatic             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Benign              |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Osteosarcoma, Metastatic             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Pars Distalis, Adenoma               | X                                                                        |         21 |
      Pars Distalis, Carcinoma             |                                                                          |          3 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Adenoma                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  18                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 0| 0| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.62MGM3                               | 5| 5| 5|                                                                 |     L      |
                                           | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Adenoma                              |       X                                                                  |          4 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Polyp Stromal                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          3 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M                                                                  |  45        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         13 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  46        |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         19 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  19                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 0| 0| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 2| 2| 2|                                                                 |     A      |
    0.62MGM3                               | 5| 5| 5|                                                                 |     L      |
                                           | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                                                                          |         11 |
      Fibroadenoma, Multiple               |                                                                          |          3 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   3        |
      Hemangioma                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Rib, Osteosarcoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Cerebellum, Carcinoma, Metastatic    |                                                                          |          2 |
      Cerebrum, Carcinoma, Metastatic      |                                                                          |          3 |
      Cerebrum, Osteosarcoma, Metastatic   |                                                                          |          1 |
      Hypothalamus, Carcinoma, Metastatic  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         11 |
      Osteosarcoma, Metastatic             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesenchymal Tumor NOS                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |         19 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  20                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|             
                                           | 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X     X     X     X                                       |             
      Sarcoma, Metastatic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +                       +               |             
      Aorta, Leukemia Mononuclear          |                                  X                                       |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Pheochromocytoma Benign              |                   X                       X                              |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X  X     X  X                                X  X           X     X|             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |       X                                         X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                            +   |             
      Lipoma                               |                         X                                                |             
      Liposarcoma                          |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|             
                                           | 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Bilateral, Adenoma                   |                                              X                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Polyp Stromal                        |    X                                   X           X                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                 +           +  +        +                           |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Axillary, Leukemia Mononuclear       |    X                             X                                       |             
      Iliac, Leukemia Mononuclear          |    X                 X           X                                       |             
      Pancreatic, Leukemia Mononuclear     |                      X           X                                       |             
      Renal, Leukemia Mononuclear          |                      X           X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                 X           X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                 X           X                                      X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                 X           X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Leukemia Mononuclear                 |    X                 X           X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X           X  X  X     X     X  X                       X           X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                             X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                         X|             
      Carcinoma, Multiple                  |                X                                                         |             
      Fibroadenoma                         |    X  X     X  X              X                                          |             
      Fibroadenoma, Multiple               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  22                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|             
                                           | 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Schwannoma Malignant,      |                                                                          |             
          Metastatic, Peripheral Nerve     |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Carcinoma, Metastatic      |                                                                          |             
      Cerebrum, Glioma NOS                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                +         |             
      Schwannoma Malignant                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                         X|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Squamous Differentiation         |                X                                                         |             
      Leukemia Mononuclear                 |    X                 X           X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +        +                    +     +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Liposarcoma                          |                                                                          |             
      Nephroblastoma                       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X           X  X  X     X     X  X                       X           X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  23                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|             
                                           | 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic                  |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X           X           X  X     X  X           X            |             
      Sarcoma, Metastatic                  |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Pheochromocytoma Benign              |                               X                 X                       X|             
      Bilateral, Pheochromocytoma Benign   |             X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X        X     X  X  X     X              X              X     X   |             
      Pars Distalis, Carcinoma             |                                                          X               |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
      Lipoma                               |                                                                   X      |             
      Liposarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  24                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|             
                                           | 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                   |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |             X                                   X  X                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                   +                       +            |             
      Leukemia Mononuclear                 |                                                                          |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                     X                                    |             
      Pancreatic, Leukemia Mononuclear     | X                                                           X            |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                   X  X     X              X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X                       X  X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                   X  X     X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X           X  X     X  X           X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X           X           X  X     X  X           X  X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                    X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                         X|             
      Carcinoma                            |                X                                                         |             
      Carcinoma, Multiple                  |                                                                          |             
      Fibroadenoma                         | X           X  X  X  X     X           X              X                  |             
      Fibroadenoma, Multiple               |                                                          X               |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +        +                                            +|             
      Subcutaneous Tissue, Fibroma         |                                                                         X|             
      Subcutaneous Tissue, Sarcoma         |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  25                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|             
                                           | 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Schwannoma Malignant,      |                                                                          |             
          Metastatic, Peripheral Nerve     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Carcinoma, Metastatic      |                                                          X               |             
      Cerebrum, Glioma NOS                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X                                                |             
      Alveolar/Bronchiolar Carcinoma       |    X                          X                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Squamous Differentiation         |                                  X                                       |             
      Leukemia Mononuclear                 | X           X                          X     X              X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Liposarcoma                          |                                                                          |             
      Nephroblastoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X           X           X  X     X  X           X  X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4|                                                                 |            |
                             DAY ON TEST   | 1| 2| 3|                                                                 |            |
                                           | 4| 7| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.25MGM3                               | 8| 8| 8|                                                                 |     L      |
                                           | 6| 7| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Sarcoma, Metastatic                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X  X                                                                     |         14 |
      Sarcoma, Metastatic                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Aorta, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Benign              |                                                                          |          5 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +                                                                  |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Pars Distalis, Adenoma               |    X                                                                     |         19 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Adenoma                      |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  27                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4|                                                                 |            |
                             DAY ON TEST   | 1| 2| 3|                                                                 |            |
                                           | 4| 7| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.25MGM3                               | 8| 8| 8|                                                                 |     L      |
                                           | 6| 7| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
      Lipoma                               |                                                                          |          2 |
      Liposarcoma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +                                                                  |  51        |
      Adenoma                              |                                                                          |          1 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   9        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Axillary, Leukemia Mononuclear       |    X                                                                     |          3 |
      Iliac, Leukemia Mononuclear          |    X                                                                     |          5 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          4 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |    X                                                                     |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 | X  X                                                                     |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X  X                                                                     |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +                                                                  |  48        |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X  X                                                                     |         21 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +                                                                  |  47        |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  28                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4|                                                                 |            |
                             DAY ON TEST   | 1| 2| 3|                                                                 |            |
                                           | 4| 7| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.25MGM3                               | 8| 8| 8|                                                                 |     L      |
                                           | 6| 7| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          2 |
      Carcinoma, Multiple                  |                                                                          |          1 |
      Fibroadenoma                         |                                                                          |         13 |
      Fibroadenoma, Multiple               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   3        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Vertebra, Schwannoma Malignant,      |                                                                          |            |
          Metastatic, Peripheral Nerve     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Cerebrum, Carcinoma, Metastatic      |                                                                          |          1 |
      Cerebrum, Glioma NOS                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Squamous Differentiation         |                                                                          |          2 |
      Leukemia Mononuclear                 | X  X                                                                     |         10 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  29                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4|                                                                 |            |
                             DAY ON TEST   | 1| 2| 3|                                                                 |            |
                                           | 4| 7| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.25MGM3                               | 8| 8| 8|                                                                 |     L      |
                                           | 6| 7| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Liposarcoma                          |       X                                                                  |          1 |
      Nephroblastoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X  X                                                                     |         21 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  30                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4| 7|             
                             DAY ON TEST   | 3| 7| 3| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9| 3|             
                                           | 2| 1| 2| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 7| 8| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lipoma                               |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                    X                     |             
      Leukemia Mononuclear                 |                      X                    X     X  X  X  X        X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Lipoma                               |                                                                         X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Adenoma               |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                      X                                            X      |             
      Pheochromocytoma Benign              | X     X        X              X              X  X           X            |             
      Bilateral, Pheochromocytoma Benign   |                                                    X  X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X        X              X        X  X        X              X            |             
      Pars Distalis, Carcinoma             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                  X                       X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                            +                                   +         |             
      Fibroma                              |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  31                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4| 7|             
                             DAY ON TEST   | 3| 7| 3| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9| 3|             
                                           | 2| 1| 2| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 7| 8| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |          X     X                                                         |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +                 +      |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                      X     X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M|             
      Leukemia Mononuclear                 |             X        X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X                             X                 X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Leukemia Mononuclear                 |             X        X                             X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X                    X     X  X  X  X        X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Leukemia Mononuclear                 |             X                                      X  X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |                   X                                   X  X     X         |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                    +  +                 +              +            |             
      Fibroma                              |    X                                                                     |             
      Papilloma                            |                                                             X            |             
      Squamous Cell Carcinoma              |                         X                                                |             
      Subcutaneous Tissue, Fibroma         |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  32                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4| 7|             
                             DAY ON TEST   | 3| 7| 3| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9| 3|             
                                           | 2| 1| 2| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 7| 8| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic                |                                                                          |             
      Cerebellum, Carcinoma, Metastatic    |                                                 X                        |             
      Cerebrum, Carcinoma, Metastatic      |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X        X                                                         |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                       X                  |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Squamous Differentiation         |                                                                          |             
      Leukemia Mononuclear                 |             X        X                          X  X              X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mixed Tumor Malignant                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X                    X     X  X  X  X        X  X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3| 9|             
                                           | 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.5MG/M3                               | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|             
                                           | 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lipoma                               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |          X                 X     X              X  X     X           X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lipoma                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                            X        X     X           X           X      |             
      Bilateral, Pheochromocytoma Benign   |                                                    X     X           X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X     X  X           X  X        X  X        X        X  X            |             
      Pars Distalis, Carcinoma             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
      Fibroma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  34                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3| 9|             
                                           | 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.5MG/M3                               | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|             
                                           | 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |       X                          X                                X      |             
      Schwannoma Malignant                 |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                      +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                      X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                      X   |             
      Renal, Leukemia Mononuclear          |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X     X                                   X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X     X                                   X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X     X              X                    X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                 X     X              X  X     X           X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  M  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                              X                           |             
      Fibroadenoma                         |                   X  X                                   X  X     X  X   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
      Fibroma                              |                                                                          |             
      Papilloma                            |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3| 9|             
                                           | 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.5MG/M3                               | 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|             
                                           | 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic                |                      X                                                   |             
      Cerebellum, Carcinoma, Metastatic    |                                                                          |             
      Cerebrum, Carcinoma, Metastatic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Squamous Differentiation         |                                                                   X      |             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +     +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             
      Carcinoma                            |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Mixed Tumor Malignant                |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                 X     X              X  X     X           X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 0| 0| 3|                                                                 |            |
                                           | 7| 4| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    2.5MG/M3                               | 1| 1| 2|                                                                 |     L      |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Lipoma                               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X                                                                  |         17 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Lipoma                               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
      Parotid Gland, Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Benign              |    X                                                                     |         13 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Pars Distalis, Adenoma               |    X  X                                                                  |         20 |
      Pars Distalis, Carcinoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Adenoma                      |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  37                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 0| 0| 3|                                                                 |            |
                                           | 7| 4| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    2.5MG/M3                               | 1| 1| 2|                                                                 |     L      |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
      Fibroma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +                                                                  |  49        |
      Carcinoma                            | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Polyp Stromal                        |                                                                          |          5 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |    X                                                                     |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  48        |
      Leukemia Mononuclear                 |    X                                                                     |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          8 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |    X  X                                                                  |         18 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  46        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         |    X  X                                                                  |         12 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  38                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 0| 0| 3|                                                                 |            |
                                           | 7| 4| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    2.5MG/M3                               | 1| 1| 2|                                                                 |     L      |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   5        |
      Fibroma                              |                                                                          |          1 |
      Papilloma                            |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Cerebellum, Carcinoma, Metastatic    |                                                                          |          1 |
      Cerebrum, Carcinoma, Metastatic      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Squamous Differentiation         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mixed Tumor Malignant                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  39                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7|                                                                 |            |
                             DAY ON TEST   | 0| 0| 3|                                                                 |            |
                                           | 7| 4| 0|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 5| 5| 5|                                                                 |     A      |
    2.5MG/M3                               | 1| 1| 2|                                                                 |     L      |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X  X                                                                  |         18 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  40                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|             
                                           | 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                   X                    X                                 |             
      Hepatocellular Adenoma               |                                                             X            |             
      Leukemia Mononuclear                 | X  X  X  X        X              X        X  X  X           X           X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                  +      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |    X           X           X        X     X                          X  X|             
      Bilateral, Pheochromocytoma Benign   |       X     X     X  X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X        X           X  X  X                 X  X        X     X      |             
      Pars Distalis, Leukemia Mononuclear  |                                              X                           |             
      Pars Intermedia, Leukemia Mononuclear|                                              X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |    X     X     X                 X                                       |             
      C-Cell, Carcinoma                    |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  41                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|             
                                           | 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                    +                     |             
      Oral, Osteosarcoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +                                                  +                     |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|          X     X     X           X  X                    X     X  X      |             
      Interstitial Cell, Adenoma           |    X  X     X     X     X  X           X  X  X     X        X           X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +           +  +                       +              +            |             
      Axillary, Leukemia Mononuclear       |                                              X                           |             
      Deep Cervical, Leukemia Mononuclear  |                                              X                           |             
      Iliac, Leukemia Mononuclear          |       X              X                       X              X            |             
      Pancreatic, Leukemia Mononuclear     |    X              X                          X                           |             
      Popliteal, Leukemia Mononuclear      |                                              X                           |             
      Renal, Leukemia Mononuclear          |                      X                       X              X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Leukemia Mononuclear                 |       X              X           X           X              X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |       X           X  X                       X  X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X        X  X                    X  X              X           X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  I  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |       X  X        X  X                       X  X           X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X        X  X     X     X        X  X  X           X           X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X                       X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  42                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|             
                                           | 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibroadenoma                         |             X                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    |                      +              +  +  +     +                       +|             
      Basal Cell Adenoma                   |                                                                          |             
      Fibroma                              |                                        X                                X|             
      Keratoacanthoma                      |                                                 X                        |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Cerebellum, Leukemia Mononuclear     |                   X                                                      |             
      Cerebrum, Leukemia Mononuclear       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Ganglion, Paraganglioma Benign       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X           X  X           X        X  X  X           X           X|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +                                   +  +                 +     +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
      Carcinoma                            |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X        X  X     X     X        X  X  X           X           X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|             
                                           | 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Leukemia Mononuclear  |                                                          X               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                   X                    X                                 |             
      Leukemia Mononuclear                 |       X  X  X     X  X  X        X     X  X  X  X  X  X        X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                X        X                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                    X        X                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X  X                    X        X                  |             
      Pheochromocytoma Benign              | X                 X                 X  X        X  X  X                  |             
      Bilateral, Pheochromocytoma Benign   |                            X     X                       X     X  X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
      Carcinoma                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                   X                              |             
      Pars Distalis, Adenoma               | X        X     X              X     X  X  X              X     X  X     X|             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Intermedia, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X                                X                     |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|             
                                           | 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             | X                                                                        |             
      Follicular Cell, Carcinoma           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                                      +            |             
      Oral, Osteosarcoma                   |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                     +                          +         |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|          X                 X  X  X  X     X  X     X  X  X               |             
      Interstitial Cell, Adenoma           | X           X        X  X                       X           X        X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +           +           +  +              +        +         |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |       X     X                          X              X                  |             
      Pancreatic, Leukemia Mononuclear     |       X  X  X           X                             X                  |             
      Popliteal, Leukemia Mononuclear      |                                                                          |             
      Renal, Leukemia Mononuclear          |                                        X              X        X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X           X        X     X  X        X  X        X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |       X  X              X              X  X  X  X  X  X  X     X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X           X  X                 X  X  X  X  X        X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X              X              X  X  X     X  X        X     X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X     X  X  X        X     X  X  X  X  X  X  X     X     X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  I  +  +  +  +  I  I  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |       X  X  X                          X  X  X     X  X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|             
                                           | 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +                 +     +  +  +     +      |             
      Basal Cell Adenoma                   |                                                          X               |             
      Fibroma                              |                                                             X            |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Cerebellum, Leukemia Mononuclear     |                                                                          |             
      Cerebrum, Leukemia Mononuclear       |                                              X                           |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
      Ganglion, Paraganglioma Benign       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X     X  X  X        X     X  X  X  X  X  X        X     X   |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                 +                              |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X  X     X  X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X     X  X  X        X     X  X  X  X  X  X  X     X     X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  46                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 6| 7| 3| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0|                                                              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |     A      |
    0 MG/M3                                | 6| 6| 6| 6|                                                              |     L      |
                                           | 0| 1| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  54        |
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  54        |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Adenoma               |                                                                          |          3 |
      Leukemia Mononuclear                 | X                                                                        |         27 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pheochromocytoma Benign              | X  X     X                                                               |         17 |
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |         10 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  54        |
      Adenoma                              |          X                                                               |          2 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +                                                               |  50        |
      Adenoma                              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |    X  X  X                                                               |         24 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  47                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 6| 7| 3| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0|                                                              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |     A      |
    0 MG/M3                                | 6| 6| 6| 6|                                                              |     L      |
                                           | 0| 1| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
      Pars Intermedia, Leukemia Mononuclear|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  54        |
      C-Cell, Adenoma                      |                                                                          |          6 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
      Oral, Osteosarcoma                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +                                                               |  54        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +                                                               |  53        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +                                                               |  54        |
      Bilateral, Interstitial Cell, Adenoma| X     X                                                                  |         20 |
      Interstitial Cell, Adenoma           |          X                                                               |         20 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |  16        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          | X                                                                        |          9 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          8 |
      Popliteal, Leukemia Mononuclear      |                                                                          |          1 |
      Renal, Leukemia Mononuclear          | X                                                                        |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +                                                               |  52        |
      Leukemia Mononuclear                 | X                                                                        |         17 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M                                                               |  49        |
      Leukemia Mononuclear                 |                                                                          |         17 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  54        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  48                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 6| 7| 3| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0|                                                              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |     A      |
    0 MG/M3                                | 6| 6| 6| 6|                                                              |     L      |
                                           | 0| 1| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +                                                               |  47        |
      Leukemia Mononuclear                 | X                                                                        |         18 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 | X        X                                                               |         31 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +                                                               |  44        |
      Leukemia Mononuclear                 |                                                                          |         11 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +                                                               |  54        |
      Fibroadenoma                         | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                                                                  |  13        |
      Basal Cell Adenoma                   |       X                                                                  |          2 |
      Fibroma                              |                                                                          |          3 |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Cerebellum, Leukemia Mononuclear     |                                                                          |          1 |
      Cerebrum, Leukemia Mononuclear       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Ganglion, Paraganglioma Benign       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +                                                               |  52        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 | X        X                                                               |         27 |
      Squamous Cell Carcinoma              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   9        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  49                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 6| 7| 3| 6|                                                              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0|                                                              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |     A      |
    0 MG/M3                                | 6| 6| 6| 6|                                                              |     L      |
                                           | 0| 1| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  54        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +                                                               |  54        |
      Leukemia Mononuclear                 | X        X                                                               |         31 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  50                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|             
                                           | 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |       X                                                                  |             
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |       X  X                                                               |             
      Hepatocellular Adenoma, Multiple     |                X                                                         |             
      Leukemia Mononuclear                 |          X  X     X  X        X  X  X     X     X  X  X  X        X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Benign              |                         X                       X  X     X     X         |             
      Bilateral, Pheochromocytoma Benign   |       X                          X                    X              X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                                               X                  |             
      Adenoma, Multiple                    |                                                 X                        |             
      Carcinoma                            |                                                                X         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X                       X        X     X              X        X   |             
      Pars Distalis, Leukemia Mononuclear  |          X                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|             
                                           | 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |    X              X                 X           X                        |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X                    X                  |             
      Fibrous Histiocytoma                 |                            X                                             |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X     X        X  X           X  X     X  X  X  X  X        X     X  X|             
      Interstitial Cell, Adenoma           |       X        X        X  X                             X               |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +        +  +           +              +  +  +           +      |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Axillary, Leukemia Mononuclear       |                                                                   X      |             
      Iliac, Leukemia Mononuclear          |                                                 X                        |             
      Inguinal, Leukemia Mononuclear       |          X                                                               |             
      Pancreatic, Leukemia Mononuclear     |       X           X              X                    X                  |             
      Renal, Leukemia Mononuclear          |          X        X                             X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X  X        X                       X  X        X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X     X  X           X  X                    X           X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X        X  X           X  X  X           X                 X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X  X  X        X  X  X              X  X           X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X        X  X  X     X     X  X  X  X        X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X     X  X              X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  52                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|             
                                           | 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                         +     +                                          |             
      Fibroma                              |                                                                          |             
      Keratoacanthoma                      |                               X                                          |             
      Squamous Cell Carcinoma              |                         X                                                |             
      Squamous Cell Papilloma              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pelvis, Hemangiosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granular Cell Tumor NOS              |                                                                          |             
      Cerebellum, Leukemia Mononuclear     |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Leukemia Mononuclear                 | X  X  X  X     X  X  X        X     X           X  X  X  X        X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                         +         |             
      Lids, Fibroma                        |                                                                X         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X        X  X  X     X     X  X  X  X        X  X   |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  53                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|             
                                           | 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Peyer's Patch, Leukemia Mononuclear  |                   X              X                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                X         |             
      Hepatocellular Carcinoma             |                                                             X            |             
      Hepatocellular Adenoma               |                                     X           X              X         |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 | X     X  X  X     X  X        X  X  X           X     X        X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Mesothelioma Malignant, Metastatic   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X              X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                                                      |             
      Pheochromocytoma Benign              |                            X     X  X           X  X                 X  X|             
      Bilateral, Pheochromocytoma Benign   |       X           X  X  X     X                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Adenoma, Multiple                    |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X  X     X        X     X     X        X     X        X  X         |             
      Pars Distalis, Leukemia Mononuclear  |       X                          X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  54                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|             
                                           | 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                 X                        |             
      Follicular Cell, Adenoma             |             X  X                 X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                       +                                             |             
      Mesothelioma Malignant, Metastatic   |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                   |             
      Fibrous Histiocytoma                 |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X     X     X  X  X  X  X  X     X        X  X  X  X  X  X  X|             
      Interstitial Cell, Adenoma           | X                    X                    X     X                        |             
      Tunic, Mesothelioma Malignant        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +     +  +           +  +                 +              +   |             
      Leukemia Mononuclear                 |                      X                                                   |             
      Axillary, Leukemia Mononuclear       |                      X                                                   |             
      Iliac, Leukemia Mononuclear          |                   X  X                                                   |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                   X              X                    X                  |             
      Renal, Leukemia Mononuclear          |                   X  X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X           X                    X              X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X  X           X                                   X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X  X           X                                   X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X  X           X                    X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X     X  X        X  X  X           X     X        X     X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                   X  X           X                    X                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  55                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|             
                                           | 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                   +        +                                             |             
      Fibroma                              |                            X                                             |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pelvis, Hemangiosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granular Cell Tumor NOS              |                                           X                              |             
      Cerebellum, Leukemia Mononuclear     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |       X  X  X     X  X           X                    X              X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +        +              +                                    |             
      Lids, Fibroma                        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
      Carcinoma                            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X           X                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X     X  X        X  X  X           X     X        X     X   |             
      Mesothelioma Malignant               |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  56                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 7| 3|                                                                 |            |
                                           | 2| 9| 3|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0.62MGM3                               | 9| 9| 9|                                                                 |     L      |
                                           | 2| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
      Fibroma                              |                                                                          |          1 |
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Hemangioma                           |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          5 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |         28 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pheochromocytoma Benign              | X                                                                        |         13 |
      Bilateral, Pheochromocytoma Benign   |    X                                                                     |         11 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          2 |
      Adenoma, Multiple                    |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  57                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 7| 3|                                                                 |            |
                                           | 2| 9| 3|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0.62MGM3                               | 9| 9| 9|                                                                 |     L      |
                                           | 2| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Pars Distalis, Adenoma               | X     X                                                                  |         18 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Adenoma                      |                                                                          |          5 |
      Follicular Cell, Adenoma             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          3 |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +                                                                  |  53        |
      Bilateral, Interstitial Cell, Adenoma| X     X                                                                  |         36 |
      Interstitial Cell, Adenoma           |    X                                                                     |         10 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +                                                                     |  19        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Axillary, Leukemia Mononuclear       |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          3 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          7 |
      Renal, Leukemia Mononuclear          |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |    X                                                                     |         13 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  58                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 7| 3|                                                                 |            |
                                           | 2| 9| 3|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0.62MGM3                               | 9| 9| 9|                                                                 |     L      |
                                           | 2| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |    X                                                                     |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |    X                                                                     |         18 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |    X                                                                     |         32 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
      Leukemia Mononuclear                 |    X                                                                     |         10 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   4        |
      Fibroma                              |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Pelvis, Hemangiosarcoma              | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Granular Cell Tumor NOS              |                                                                          |          1 |
      Cerebellum, Leukemia Mononuclear     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |         23 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Lids, Fibroma                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  59                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 7| 3|                                                                 |            |
                                           | 2| 9| 3|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 1| 1| 1|                                                                 |     A      |
    0.62MGM3                               | 9| 9| 9|                                                                 |     L      |
                                           | 2| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |    X                                                                     |         32 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  60                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|             
                                           | 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anus, Leiomyoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Leukemia Mononuclear  |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                   X      |             
      Hepatocellular Carcinoma, Multiple   |                                                       X                  |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |       X           X     X  X  X  X        X     X     X  X           X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +                                                               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                 X                              |             
      Pheochromocytoma Malignant           |       X                                                                  |             
      Pheochromocytoma Benign              |    X        X           X  X  X        X           X     X           X   |             
      Bilateral, Pheochromocytoma Benign   | X        X                                X                    X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
      Carcinoma                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |                                           X                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Adenoma               |                                  X  X  X     X                    X  X   |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  61                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|             
                                           | 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Carcinoma           | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                        X  X                              |             
      C-Cell, Carcinoma                    |                                     X                                    |             
      Follicular Cell, Adenoma             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
      Lipoma                               |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                   X           X                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X     X  X  X  X     X              X  X  X           X   |             
      Interstitial Cell, Adenoma           |                                        X  X     X           X  X  X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +  +        +                 +  +     +     +     +   |             
      Leukemia Mononuclear                 |                               X                                          |             
      Axillary, Leukemia Mononuclear       |                   X                                                      |             
      Iliac, Leukemia Mononuclear          |                   X                                X                 X   |             
      Pancreatic, Leukemia Mononuclear     |                   X  X        X                 X                        |             
      Renal, Leukemia Mononuclear          |                   X  X        X                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X  X  X  X  X        X     X  X  X  X     X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X     X  X                 X  X  X           X   |             
      Squamous Cell Carcinoma, Metastatic  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X  X  X  X        X     X  X  X  X           X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X  X  X  X  X  X        X     X  X  X  X     X     X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  62                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|             
                                           | 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Leukemia Mononuclear                 |       X     X     X  X  X  X  X  X        X     X  X  X  X     X     X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                 X     X                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
      Leukemia Mononuclear                 |                         X     X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +              +  +           +           +                 +|             
      Basal Cell Adenoma                   |             X                                                            |             
      Fibroma                              |                                                                         X|             
      Keratoacanthoma                      |                                                                          |             
      Lipoma                               |                                           X                              |             
      Squamous Cell Papilloma              |                            X                                             |             
      Trichoepithelioma                    |                                                                          |             
      Scrotum, Fibroma                     |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                         X                                                |             
      Leukemia Mononuclear                 |                                                                          |             
      Cerebellum, Leukemia Mononuclear     |                                                                          |             
      Cerebrum, Leukemia Mononuclear       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                             X     X      |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Squamous Differentiation         |                                              X                           |             
      Leukemia Mononuclear                 |             X           X  X  X  X        X     X  X  X  X     X     X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
      Fibroma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                 +                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  63                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|             
                                           | 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X     X                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X  X  X  X  X  X        X     X  X  X  X     X     X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  64                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|             
                                           | 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Anus, Leiomyoma                      |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |          X           X                                         X         |             
      Leukemia Mononuclear                 | X                 X                          X              X  X        X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                            +                                             |             
      Squamous Cell Carcinoma              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X     X     X              X  X     X                    X               |             
      Bilateral, Pheochromocytoma Benign   |                                  X           X        X     X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Carcinoma                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X        X        X  X  X     X           X        X  X            |             
      Pars Distalis, Leukemia Mononuclear  |                                              X                           |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  65                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|             
                                           | 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Carcinoma           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      C-Cell, Adenoma                      | X                                   X                                    |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
      Lipoma                               |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                             X                     |             
      Carcinoma                            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X     X     X  X           X  X     X        X  X              X   |             
      Interstitial Cell, Adenoma           | X        X              X              X     X           X        X     X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +                                   +              +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                             X            |             
      Pancreatic, Leukemia Mononuclear     |                                              X              X  X        X|             
      Renal, Leukemia Mononuclear          |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X              X           X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                          X              X            |             
      Squamous Cell Carcinoma, Metastatic  |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                          X              X           X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                          X              X           X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  66                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|             
                                           | 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Leukemia Mononuclear                 | X                 X                    X  X  X              X  X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X              X           X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +        +     +     +        +        +              +      |             
      Basal Cell Adenoma                   |                                                                          |             
      Fibroma                              |                                                                          |             
      Keratoacanthoma                      |                                  X                                       |             
      Lipoma                               |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                            X                                             |             
      Scrotum, Fibroma                     |                                                                   X      |             
      Subcutaneous Tissue, Sarcoma         |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Cerebellum, Leukemia Mononuclear     |                                                                          |             
      Cerebrum, Leukemia Mononuclear       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Alveolar/Bronchiolar Carcinoma       |                                                                X         |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Squamous Differentiation         |                      X                                                   |             
      Leukemia Mononuclear                 | X                 X                          X              X  X        X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Fibroma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  67                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|             
                                           | 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X              X            |             
      Renal Tubule, Adenoma                |                   X                                                      |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X                    X  X  X              X  X        X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  68                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6|                                                                 |            |
                             DAY ON TEST   | 1| 5| 8|                                                                 |            |
                                           | 9| 7| 1|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.25MGM3                               | 2| 2| 2|                                                                 |     L      |
                                           | 3| 4| 5|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Anus, Leiomyoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          3 |
      Leukemia Mononuclear                 | X  X  X                                                                  |         20 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X  X                                                                     |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |    X                                                                     |          3 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              | X                                                                        |         17 |
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |          9 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  69                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6|                                                                 |            |
                             DAY ON TEST   | 1| 5| 8|                                                                 |            |
                                           | 9| 7| 1|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.25MGM3                               | 2| 2| 2|                                                                 |     L      |
                                           | 3| 4| 5|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +                                                                  |  49        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Pars Distalis, Adenoma               |       X                                                                  |         16 |
      Pars Distalis, Leukemia Mononuclear  | X                                                                        |          2 |
      Pars Intermedia, Carcinoma           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          4 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Lipoma                               |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +                                                                  |  53        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +                                                                  |  53        |
      Bilateral, Interstitial Cell, Adenoma|       X                                                                  |         27 |
      Interstitial Cell, Adenoma           | X  X                                                                     |         16 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                                                                  |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          | X     X                                                                  |          6 |
      Pancreatic, Leukemia Mononuclear     | X     X                                                                  |         10 |
      Renal, Leukemia Mononuclear          | X     X                                                                  |          7 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  70                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6|                                                                 |            |
                             DAY ON TEST   | 1| 5| 8|                                                                 |            |
                                           | 9| 7| 1|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.25MGM3                               | 2| 2| 2|                                                                 |     L      |
                                           | 3| 4| 5|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X  X                                                                     |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  50        |
      Leukemia Mononuclear                 | X  X  X                                                                  |         14 |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X  X  X                                                                  |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 | X  X  X                                                                  |         21 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Fibrosarcoma                         |       X                                                                  |          1 |
      Leukemia Mononuclear                 | X  X  X                                                                  |         26 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  47        |
      Leukemia Mononuclear                 | X                                                                        |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Fibroadenoma                         |       X                                                                  |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  14        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Fibroma                              |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Lipoma                               |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Trichoepithelioma                    |                                                                          |          1 |
      Scrotum, Fibroma                     |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Astrocytoma NOS                      |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                                                        |          1 |
      Cerebellum, Leukemia Mononuclear     |    X                                                                     |          1 |
      Cerebrum, Leukemia Mononuclear       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  71                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6|                                                                 |            |
                             DAY ON TEST   | 1| 5| 8|                                                                 |            |
                                           | 9| 7| 1|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 3| 3| 3|                                                                 |     A      |
    1.25MGM3                               | 2| 2| 2|                                                                 |     L      |
                                           | 3| 4| 5|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Squamous Differentiation         |                                                                          |          2 |
      Leukemia Mononuclear                 | X  X  X                                                                  |         21 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Fibroma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X  X                                                                     |          7 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
      Transitional Epithelium, Carcinoma   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  53        |
      Leukemia Mononuclear                 | X  X  X                                                                  |         26 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  72                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|             
                                           | 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic     |                            X                                             |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Histiocytic Sarcoma, Metastatic, Skin|                                                                          |             
      Leukemia Mononuclear                 | X  X     X  X  X  X  X  X  X                 X  X        X     X  X      |             
      Mesothelioma Malignant, Metastatic   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                     X                                    |             
      Lymphatic, Leukemia Mononuclear      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic   |                                     X                                    |             
      Lymphatic, Leukemia Mononuclear      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Lung          | X                                                                        |             
      Leukemia Mononuclear                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  73                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|             
                                           | 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
      Pheochromocytoma Malignant           |                   X                 X     X                              |             
      Pheochromocytoma Benign              |                   X     X                    X  X                        |             
      Bilateral, Pheochromocytoma Benign   | X  X     X  X  X                 X                       X  X     X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                               X                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  M  +  +  +  +  +|             
      Bilateral, Leukemia Mononuclear      |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X     X     X     X  X  X                 X                       X|             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                                                        |             
      Follicular Cell, Adenoma             |                                                                   X      |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                  +  +                  |             
      Basal Cell Carcinoma                 |                                                       X                  |             
      Carcinoma, Metastatic, Lung          | X                                                                        |             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                     X                       X            |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant, Metastatic   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Bilateral, Interstitial Cell, Adenoma|    X  X  X     X                 X           X     X              X  X   |             
      Interstitial Cell, Adenoma           | X           X     X  X     X  X     X     X     X     X  X  X  X         |             
      Tunic, Mesothelioma Malignant        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  74                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|             
                                           | 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +        +              +                     |             
      Leukemia Mononuclear                 |                                                                          |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                   X                                                      |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X           X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X  X           X                 X        X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X  X                             X        X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X           X                    X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X  X  X  X  X  X  X           X  X  X  X     X     X  X      |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic                       |                                           X                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Lung          | X                                                                        |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Lymphatic, Leukemia Mononuclear      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +                             +                           |             
      Keratoacanthoma                      |                X                                                         |             
      Papilloma                            |                                                                          |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
      Fibrous Histiocytoma                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                    +                     |             
      Ganglion, Paraganglioma Benign       |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  75                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|             
                                           | 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X                                                         |             
      Alveolar/Bronchiolar Carcinoma       | X                                                                        |             
      Fibrous Histiocytoma, Metastatic     |                            X                                             |             
      Histiocytic Sarcoma, Metastatic, Skin|                                                                          |             
      Leukemia Mononuclear                 |                   X           X                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +  +     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic, Skin|                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X  X     X  X  X  X  X  X  X  X           X  X  X  X     X     X  X      |             
      Mesothelioma Malignant               |                                     X                       X            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  76                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|             
                                           | 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic     |                                                                          |             
      Hepatocellular Carcinoma             | X                                                                        |             
      Hepatocellular Adenoma               | X           X                                                            |             
      Histiocytic Sarcoma, Metastatic, Skin|                                                 X                        |             
      Leukemia Mononuclear                 | X     X     X           X        X     X  X  X     X  X  X  X     X  X  X|             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                     X     X|             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
      Lymphatic, Leukemia Mononuclear      |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
      Lymphatic, Leukemia Mononuclear      |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
      Leukemia Mononuclear                 |                                                    X                    X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  77                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|             
                                           | 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X  X  X            |             
      Pheochromocytoma Malignant           |                   X        X                                      X      |             
      Pheochromocytoma Benign              |       X        X        X  X     X        X     X  X     X        X  X   |             
      Bilateral, Pheochromocytoma Benign   | X  X     X           X              X  X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Leukemia Mononuclear      |                                                                         X|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |          X  X                 X                                      X   |             
      Pars Distalis, Leukemia Mononuclear  |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                  X                                       |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
      Basal Cell Carcinoma                 |                                                                          |             
      Carcinoma, Metastatic, Lung          |                                                                          |             
      Fibrosarcoma                         |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                          +               |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                           X|             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X        X  X     X     X     X  X              X  X  X  X|             
      Interstitial Cell, Adenoma           |             X     X  X              X     X           X  X  X            |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  78                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|             
                                           | 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +                       +  +  +  +     +        +     +     +|             
      Leukemia Mononuclear                 |                                           X        X                     |             
      Axillary, Leukemia Mononuclear       |                                                                         X|             
      Iliac, Leukemia Mononuclear          |                                     X                                    |             
      Pancreatic, Leukemia Mononuclear     | X           X                                X     X        X     X     X|             
      Renal, Leukemia Mononuclear          |             X                       X        X     X              X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X                             X  X           X  X     X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X                                         X     X        X     X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X                             X  X     X     X  X     X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X                             X  X     X  X  X  X     X  X  X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X           X        X  X  X  X  X     X  X  X  X     X  X  X|             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Lung          |                                                                          |             
      Leukemia Mononuclear                 |             X                                      X              X     X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphatic, Leukemia Mononuclear      |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    |                         +                    +  +                    +   |             
      Keratoacanthoma                      |                                                                          |             
      Papilloma                            |                                                                      X   |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Fibrous Histiocytoma                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Ganglion, Paraganglioma Benign       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  79                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|             
                                           | 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                        X                                 |             
      Alveolar/Bronchiolar Carcinoma       |                                                                      X   |             
      Fibrous Histiocytoma, Metastatic     |                                                                          |             
      Histiocytic Sarcoma, Metastatic, Skin|                                                 X                        |             
      Leukemia Mononuclear                 | X           X                    X        X  X     X  X  X  X     X     X|             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic                       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +  +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic, Skin|                                                 X                        |             
      Leukemia Mononuclear                 |                                                    X        X     X     X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                 X                        |             
      Leukemia Mononuclear                 | X  X  X     X           X        X  X  X  X  X     X  X  X  X     X  X  X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  80                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    2.5MG/M3                               | 5| 5| 5|                                                                 |     L      |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  52        |
      Fibrous Histiocytoma, Metastatic     |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Histiocytic Sarcoma, Metastatic, Skin|                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         29 |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
      Submandibular Gland, Leukemia        |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
      Lymphatic, Leukemia Mononuclear      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  52        |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
      Lymphatic, Leukemia Mononuclear      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  81                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    2.5MG/M3                               | 5| 5| 5|                                                                 |     L      |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Carcinoma, Metastatic, Lung          |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |       X                                                                  |          5 |
      Pheochromocytoma Malignant           |                                                                          |          6 |
      Pheochromocytoma Benign              |    X                                                                     |         16 |
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |         16 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +                                                                  |  49        |
      Bilateral, Leukemia Mononuclear      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Pars Distalis, Adenoma               |                                                                          |         12 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Adenoma                      |                                                                          |          2 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   4        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Carcinoma, Metastatic, Lung          |                                                                          |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +                                                                  |  52        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                                                                  |  51        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +                                                                  |  52        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  82                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    2.5MG/M3                               | 5| 5| 5|                                                                 |     L      |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X                                                                  |         26 |
      Interstitial Cell, Adenoma           |                                                                          |         21 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  15        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          7 |
      Renal, Leukemia Mononuclear          |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |       X                                                                  |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |       X                                                                  |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  51        |
      Leukemia Mononuclear                 |                                                                          |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |       X                                                                  |         16 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |       X                                                                  |         35 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +                                                                  |  48        |
      Carcinoma, Metastatic, Lung          |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  52        |
      Lymphatic, Leukemia Mononuclear      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   6        |
      Keratoacanthoma                      |                                                                          |          1 |
      Papilloma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  83                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    2.5MG/M3                               | 5| 5| 5|                                                                 |     L      |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Ganglion, Paraganglioma Benign       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Fibrous Histiocytoma, Metastatic     |                                                                          |          1 |
      Histiocytic Sarcoma, Metastatic, Skin|                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |         14 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  52        |
      Histiocytic Sarcoma, Metastatic, Skin|                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +                                                                  |  52        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  84                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 03/31/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:32:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0|                                                                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |     T      |
                               ANIMAL ID   | 4| 4| 4|                                                                 |     A      |
    2.5MG/M3                               | 5| 5| 5|                                                                 |     L      |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X                                                                  |         35 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  85                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.