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TDMS Study 05123-05 Pathology Tables


                                                    NEOPLASMS BY INDIVIDUAL ANIMAL
                                                            NICKEL OXIDE


NTP Experiment-Test: 05123-05                                                                                     Report: PEIRPT04
Study Type: CHRONIC                                                                                               Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29


                                                          66 WEEK SSAC


       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  001313991

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     07/06/89 - 07/07/89

       Treatment Groups:       Include 002    0 MG/M3
                               Include 006    0.62MGM3
                               Include 010    1.25MGM3
                               Include 014    2.5MG/M3
                               Include 001    0 MG/M3
                               Include 005    0.62MGM3
                               Include 009    1.25MGM3
                               Include 013    2.5MG/M3
























Note:  Animals arranged according to CID number

                                                             Page   1

NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 0| 0| 0| 0| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 1|                                                           |     A      |
    0 MG/M3                                | 6| 6| 7| 8| 2|                                                           |     L      |
                                           | 6| 8| 8| 7| 3|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
      Pars Distalis, Adenoma               |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
      C-Cell, Adenoma                      |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 0| 0| 0| 0| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 1|                                                           |     A      |
    0 MG/M3                                | 6| 6| 7| 8| 2|                                                           |     L      |
                                           | 6| 8| 8| 7| 3|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          M                                                               |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 0| 0| 0| 0| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |     A      |
    0.62MGM3                               | 2| 3| 4| 5| 6|                                                           |     L      |
                                           | 0| 4| 3| 5| 0|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
      Pars Distalis, Adenoma               | X  X     X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
      C-Cell, Adenoma                      |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 0| 0| 0| 0| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |     A      |
    0.62MGM3                               | 2| 3| 4| 5| 6|                                                           |     L      |
                                           | 0| 4| 3| 5| 0|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 0| 0| 0| 0| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |     A      |
    1.25MGM3                               | 2| 3| 6| 7| 9|                                                           |     L      |
                                           | 9| 8| 4| 0| 0|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  M                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |
      Polyp Stromal                        |       X     X                                                            |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +                                                            |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 0| 0| 0| 0| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |     A      |
    1.25MGM3                               | 2| 3| 6| 7| 9|                                                           |     L      |
                                           | 9| 8| 4| 0| 0|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 0| 0| 0| 0| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 4| 5| 5| 5| 5|                                                           |     A      |
    2.5MG/M3                               | 8| 0| 0| 0| 1|                                                           |     L      |
                                           | 5| 4| 6| 8| 0|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
      Pars Distalis, Adenoma               | X                                                                        |          1 |
      Pars Intermedia, Adenoma             |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |
      Polyp Stromal                        |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 0| 0| 0| 0| 0|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 4| 5| 5| 5| 5|                                                           |     A      |
    2.5MG/M3                               | 8| 0| 0| 0| 1|                                                           |     L      |
                                           | 5| 4| 6| 8| 0|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 9| 9| 9| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |     A      |
    0 MG/M3                                | 2| 2| 3| 5| 6|                                                           |     L      |
                                           | 0| 5| 6| 5| 2|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
      C-Cell, Adenoma                      |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |
      Interstitial Cell, Adenoma           | X  X  X                                                                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 9| 9| 9| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |     A      |
    0 MG/M3                                | 2| 2| 3| 5| 6|                                                           |     L      |
                                           | 0| 5| 6| 5| 2|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +  +  +                                                               |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 9| 9| 9| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |     A      |
    0.62MGM3                               | 3| 5| 8| 9| 9|                                                           |     L      |
                                           | 4| 4| 3| 1| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
      Pars Distalis, Adenoma               |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |
      Interstitial Cell, Adenoma           |    X  X  X  X                                                            |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 9| 9| 9| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |     A      |
    0.62MGM3                               | 3| 5| 8| 9| 9|                                                           |     L      |
                                           | 4| 4| 3| 1| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 9| 9| 9| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 2| 3| 3| 3| 3|                                                           |     A      |
    1.25MGM3                               | 7| 0| 0| 1| 1|                                                           |     L      |
                                           | 1| 1| 6| 5| 7|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
      Pheochromocytoma Benign              | X  X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
      C-Cell, Adenoma                      |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  14                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 9| 9| 9| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 2| 3| 3| 3| 3|                                                           |     A      |
    1.25MGM3                               | 7| 0| 0| 1| 1|                                                           |     L      |
                                           | 1| 1| 6| 5| 7|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +     +                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  15                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 9| 9| 9| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 3| 4| 4| 4| 4|                                                           |     A      |
    2.5MG/M3                               | 9| 2| 4| 5| 5|                                                           |     L      |
                                           | 2| 3| 5| 0| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |
      Bilateral, Interstitial Cell, Adenoma|    X                                                                     |          1 |
      Interstitial Cell, Adenoma           |       X  X  X                                                            |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  16                                                               
NTP Experiment-Test: 05123-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:47:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5|                                                           |            |
                                           | 9| 9| 9| 9| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 3| 4| 4| 4| 4|                                                           |     A      |
    2.5MG/M3                               | 9| 2| 4| 5| 5|                                                           |     L      |
                                           | 2| 3| 5| 0| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M                                                            |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |   1        |
      Sebaceous Gland, Adenoma             | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
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                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------