National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1369

TDMS Study 05123-05 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            NICKEL OXIDE


NTP Experiment-Test: 05123-05                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  001313991

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          58            7           58            7           58            7           
  Scheduled Sacrifice                                  5            7            5            7            5            7           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                27                        24                        27                        
    Natural Death                                      5                         3                         6                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                21                        26                        20                        
  Animals Examined Microscopically                    58            7           58            7           58            7           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (57)                      (58)                      (58)                      
      Sarcoma, Metastatic                                                                                  1 (2%)                   
   Liver                                              (58)         (1)          (58)                      (58)                      
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Sarcoma, Metastatic                                                                                  1 (2%)                   
   Mesentery                                                                                                           (1)          
      Lipoma                                                                                                            1 (100%)    
   Pancreas                                           (57)                      (58)                      (58)                      
   Salivary Glands                                    (57)                      (57)                      (56)                      
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
   Tooth                                              (1)                                                                           
      Odontoma                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)                       (1)                       (2)                       
   Heart                                              (58)                      (58)                      (58)                      
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)                      (58)                      (58)                      
      Carcinoma                                        1 (2%)                                                                       
   Adrenal Medulla                                    (56)                      (57)                      (57)                      
      Pheochromocytoma Benign                          3 (5%)                    7 (12%)                   5 (9%)                   
      Bilateral, Pheochromocytoma Benign               1 (2%)                                              1 (2%)                   
   Islets, Pancreatic                                 (57)                      (58)                      (58)                      
      Adenoma                                          1 (2%)                    1 (2%)                    1 (2%)                   
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (57)                      (57)         (2)          (57)         (3)          
      Pars Distalis, Adenoma                          21 (37%)                  24 (42%)                  19 (33%)                  
      Pars Distalis, Carcinoma                         1 (2%)                    3 (5%)                    1 (2%)                   
   Thyroid Gland                                      (57)                      (57)                      (58)                      
      C-Cell, Adenoma                                  2 (4%)                    2 (4%)                    3 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (6)                       (1)                       (3)                       
      Fibrosarcoma                                     1 (17%)                                                                      
      Fibrous Histiocytoma                                                       1 (100%)                                           
      Lipoma                                                                                               2 (67%)                  
      Liposarcoma                                                                                          1 (33%)                  
      Osteosarcoma                                     1 (17%)                                                                      
      Squamous Cell Carcinoma                          2 (33%)                                                                      
      Oral, Squamous Cell Carcinoma                    1 (17%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)                      (58)                      (56)                      
      Adenoma                                          1 (2%)                    4 (7%)                    1 (2%)                   
      Carcinoma                                        2 (3%)                                                                       
      Bilateral, Adenoma                                                         1 (2%)                    1 (2%)                   
   Ovary                                              (58)                      (58)                      (58)         (2)          
      Granulosa-Theca Tumor Benign                     1 (2%)                                                                       
   Uterus                                             (58)                      (58)                      (57)                      
      Polyp Stromal                                    9 (16%)                   2 (3%)                    8 (14%)                  
   Vagina                                             (2)                       (1)                       (1)                       
      Polyp                                            1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (57)                      (58)                      (58)                      
   Lymph Node                                         (14)                      (6)                       (9)                       
   Lymph Node, Bronchial                              (54)         (6)          (55)         (7)          (58)         (7)          
   Lymph Node, Mandibular                             (52)                      (50)                      (56)                      
      Squamous Cell Carcinoma, Metastatic              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (56)                      (58)                      (58)                      
   Lymph Node, Mediastinal                            (53)         (6)          (51)         (7)          (52)         (6)          
   Spleen                                             (58)                      (58)                      (58)                      
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (53)                      (54)         (1)          (52)                      
      Thymoma NOS                                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)                      (58)                      (58)                      
      Adenoma                                          1 (2%)                    1 (2%)                    1 (2%)                   
      Carcinoma                                                                                            2 (3%)                   
      Carcinoma, Multiple                              1 (2%)                                              1 (2%)                   
      Fibroadenoma                                    11 (19%)                  11 (19%)                  13 (22%)                  
      Fibroadenoma, Multiple                           1 (2%)                    3 (5%)                    2 (3%)                   
   Skin                                               (4)                       (3)                       (3)                       
      Basal Cell Adenoma                               1 (25%)                                                                      
      Hemangioma                                                                 1 (33%)                                            
      Keratoacanthoma                                  1 (25%)                                                                      
      Squamous Cell Papilloma                          2 (50%)                                                                      
      Subcutaneous Tissue, Fibroma                                                                         1 (33%)                  
      Subcutaneous Tissue, Sarcoma                                                                         1 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)                      (58)                      (58)                      
      Rib, Osteosarcoma                                                          1 (2%)                                             
      Vertebra, Schwannoma Malignant, Metastatic,                                                                                   
           Peripheral Nerve                                                                                1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)                      (58)                      (58)                      
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Cerebellum, Carcinoma, Metastatic                                          2 (3%)                                             
      Cerebrum, Carcinoma, Metastatic                                            3 (5%)                    1 (2%)                   
      Cerebrum, Glioma NOS                                                                                 1 (2%)                   
      Cerebrum, Osteosarcoma, Metastatic                                         1 (2%)                                             
      Hypothalamus, Carcinoma, Metastatic                                        1 (2%)                                             
   Peripheral Nerve                                                                                       (1)                       
      Schwannoma Malignant                                                                                 1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (7)          (58)         (7)          (58)         (7)          
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                              1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                                                                       3 (5%)                   
      Alveolar/Bronchiolar Carcinoma, Squamous                                                                                      
          Differentiation                                                                                  2 (3%)                   
      Carcinoma, Metastatic, Adrenal Cortex            1 (2%)                                                                       
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
                                                             Page   4                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (7)          (58)         (7)          (58)         (7)          
      Liposarcoma                                                                                          1 (2%)                   
      Mesenchymal Nos                                                            1 (2%)                                             
      Nephroblastoma                                                                                       1 (2%)                   
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
   Urinary Bladder                                    (57)                      (58)                      (58)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(58)        *(7)         *(58)        *(7)         *(58)        *(7)          
      Leukemia Mononuclear                            22 (38%)                  19 (33%)                  21 (36%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            53                      53                      53           1               
     Total Primary Neoplasms                           93                      84                      95           1               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40                      42                      39           1               
     Total Benign Neoplasms                            59                      58                      59           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32                      25                      30                           
     Total Malignant Neoplasms                         33                      25                      35                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       5                       3                           
     Total Metastatic Neoplasm                          3                      11                       4                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       1                       1                           
     Total Uncertain Neoplasms                          1                       1                       1                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2.5MG/M3     2.5MG/M3                                                            
                                                                 LUNGTX                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          58            7                                                               
  Scheduled Sacrifice                                  5            6                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24            1                                                               
    Natural Death                                      3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                26                                                                            
  Animals Examined Microscopically                    58            7                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (58)         (1)                                                              
      Lipoma                                           1 (2%)                                                                       
   Liver                                              (58)         (1)                                                              
      Hepatocellular Adenoma                           1 (2%)                                                                       
   Mesentery                                          (1)                                                                           
      Lipoma                                           1 (100%)                                                                     
   Salivary Glands                                    (57)         (1)                                                              
      Parotid Gland, Adenoma                           1 (2%)                                                                       
   Stomach, Forestomach                               (58)         (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)         (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (1)                                                              
   Adrenal Medulla                                    (57)         (1)                                                              
      Pheochromocytoma Benign                         13 (23%)                                                                      
      Bilateral, Pheochromocytoma Benign               5 (9%)                                                                       
   Pituitary Gland                                    (58)         (2)                                                              
      Pars Distalis, Adenoma                          21 (36%)                                                                      
      Pars Distalis, Carcinoma                         2 (3%)                                                                       
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (58)                                                                          
      C-Cell, Adenoma                                  2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2.5MG/M3     2.5MG/M3                                                            
                                                                 LUNGTX                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (3)                                                                           
      Fibroma                                          1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (54)         (1)                                                              
      Carcinoma                                        1 (2%)                                                                       
   Uterus                                             (58)         (1)                                                              
      Polyp Stromal                                    6 (10%)                                                                      
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (4)                                                                           
   Lymph Node, Bronchial                              (56)         (7)                                                              
   Lymph Node, Mandibular                             (53)         (1)                                                              
   Lymph Node, Mesenteric                             (58)         (1)                                                              
   Lymph Node, Mediastinal                            (54)         (5)                                                              
   Spleen                                             (58)         (1)                                                              
   Thymus                                             (51)         (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (1)                                                              
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                    12 (21%)                                                                      
   Skin                                               (5)                                                                           
      Fibroma                                          1 (20%)                                                                      
      Papilloma                                        1 (20%)                                                                      
      Squamous Cell Carcinoma                          1 (20%)                                                                      
      Subcutaneous Tissue, Fibroma                     1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2.5MG/M3     2.5MG/M3                                                            
                                                                 LUNGTX                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (1)                                                              
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Cerebellum, Carcinoma, Metastatic                1 (2%)                                                                       
      Cerebrum, Carcinoma, Metastatic                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (7)                                                              
      Alveolar/Bronchiolar Adenoma                     3 (5%)                                                                       
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Squamous                                                                                      
          Differentiation                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (7)                                                              
      Mixed Tumor Malignant                            1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(58)        *(7)                                                              
      Leukemia Mononuclear                            18 (31%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2.5MG/M3     2.5MG/M3                                                            
                                                                 LUNGTX                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            53                                                                           
     Total Primary Neoplasms                          100                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44                                                                           
     Total Benign Neoplasms                            73                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25                                                                           
     Total Malignant Neoplasms                         27                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          3                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          59            6           58            7           58            7           
  Scheduled Sacrifice                                  5            6            5            7            5            7           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                39                        35                        32                        
    Natural Death                                      1                         3                         6                        
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                                     1                        
    Terminal Sacrifice                                14                        15                        14                        
  Animals Examined Microscopically                    59            6           58            7           58            7           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (59)                      (58)                      (57)                      
      Anus, Leiomyoma                                                                                      1 (2%)                   
   Intestine Small, Ileum                             (59)                      (58)                      (58)                      
      Fibroma                                                                    1 (2%)                                             
   Liver                                              (59)                      (58)                      (58)         (1)          
      Hemangioma                                                                 1 (2%)                                             
      Hepatocellular Carcinoma                         2 (3%)                    1 (2%)                    1 (2%)                   
      Hepatocellular Carcinoma, Multiple                                                                   1 (2%)                   
      Hepatocellular Adenoma                           3 (5%)                    5 (9%)                    3 (5%)                   
      Hepatocellular Adenoma, Multiple                                           1 (2%)                                             
   Mesentery                                          (1)                       (1)                                                 
   Pancreas                                           (59)                      (58)                      (58)                      
   Salivary Glands                                    (59)                      (58)                      (58)                      
      Squamous Cell Carcinoma                                                                              1 (2%)                   
   Tongue                                                                                                 (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)                      (58)                      (58)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)                      (58)                      (58)                      
      Adenoma                                                                    1 (2%)                                             
   Adrenal Medulla                                    (59)                      (57)                      (58)                      
      Pheochromocytoma Malignant                                                                           1 (2%)                   
      Pheochromocytoma Benign                         17 (29%)                  13 (23%)                  19 (33%)                  
                                                             Page  11                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, Pheochromocytoma Benign              10 (17%)                  11 (19%)                   9 (16%)                  
   Islets, Pancreatic                                 (59)                      (58)                      (58)                      
      Adenoma                                          2 (3%)                    2 (3%)                    2 (3%)                   
      Adenoma, Multiple                                                          1 (2%)                                             
      Carcinoma                                        1 (2%)                    1 (2%)                    2 (3%)                   
   Parathyroid Gland                                  (54)                      (55)                      (54)                      
      Adenoma                                          1 (2%)                    1 (2%)                    1 (2%)                   
   Pituitary Gland                                    (58)                      (57)                      (57)                      
      Pars Distalis, Adenoma                          24 (41%)                  19 (33%)                  16 (28%)                  
      Pars Intermedia, Carcinoma                                                                           1 (2%)                   
   Thyroid Gland                                      (59)                      (58)                      (57)                      
      C-Cell, Adenoma                                  7 (12%)                   5 (9%)                    5 (9%)                   
      C-Cell, Carcinoma                                1 (2%)                                              1 (2%)                   
      Follicular Cell, Adenoma                         1 (2%)                    3 (5%)                    2 (4%)                   
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (3)                       (2)                       (2)                       
      Lipoma                                                                                               2 (100%)                 
      Oral, Osteosarcoma                               1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (59)                      (58)                      (58)                      
   Preputial Gland                                    (59)                      (58)                      (58)                      
      Adenoma                                          1 (2%)                    3 (5%)                    2 (3%)                   
      Carcinoma                                                                                            1 (2%)                   
      Fibrous Histiocytoma                                                       1 (2%)                                             
   Prostate                                           (58)                      (58)                      (58)                      
      Adenoma                                                                                              1 (2%)                   
   Seminal Vesicle                                    (59)                      (58)                      (58)                      
   Testes                                             (59)                      (58)                      (58)                      
      Bilateral, Interstitial Cell, Adenoma           20 (34%)                  36 (62%)                  27 (47%)                  
      Interstitial Cell, Adenoma                      23 (39%)                  14 (24%)                  16 (28%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)                      (58)                      (58)                      
   Lymph Node                                         (16)                      (19)                      (16)         (1)          
   Lymph Node, Bronchial                              (57)         (6)          (56)         (7)          (58)         (7)          
   Lymph Node, Mandibular                             (54)                      (56)                      (55)                      
      Squamous Cell Carcinoma, Metastatic                                                                  1 (2%)                   
   Lymph Node, Mesenteric                             (59)                      (58)                      (58)                      
                                                             Page  12                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mediastinal                            (52)         (6)          (57)         (6)          (57)         (6)          
   Spleen                                             (59)                      (58)                      (58)                      
      Fibrosarcoma                                                                                         1 (2%)                   
   Thymus                                             (48)                      (53)                      (52)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)                      (58)                      (58)                      
      Fibroadenoma                                     2 (3%)                                              1 (2%)                   
   Skin                                               (13)                      (4)                       (14)                      
      Basal Cell Adenoma                               2 (15%)                                             1 (7%)                   
      Fibroma                                          3 (23%)                   1 (25%)                   1 (7%)                   
      Keratoacanthoma                                  1 (8%)                    1 (25%)                   1 (7%)                   
      Lipoma                                                                                               1 (7%)                   
      Squamous Cell Carcinoma                                                    1 (25%)                                            
      Squamous Cell Papilloma                                                    1 (25%)                   1 (7%)                   
      Trichoepithelioma                                                                                    1 (7%)                   
      Scrotum, Fibroma                                                                                     1 (7%)                   
      Subcutaneous Tissue, Neurofibrosarcoma           1 (8%)                                                                       
      Subcutaneous Tissue, Sarcoma                                                                         1 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)                      (58)                      (58)                      
      Pelvis, Hemangiosarcoma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)                      (58)                      (58)                      
      Astrocytoma NOS                                                                                      1 (2%)                   
      Granular Cell Tumor NOS                                                    1 (2%)                                             
   Peripheral Nerve                                   (1)                                                                           
      Ganglion, Paraganglioma Benign                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (6)          (58)         (7)          (58)         (7)          
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                    3 (5%)                   
      Alveolar/Bronchiolar Carcinoma                                                                       1 (2%)                   
      Alveolar/Bronchiolar Carcinoma, Squamous                                                                                      
          Differentiation                                                                                  2 (3%)                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page  13                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                                    (1)                       
      Fibroma                                                                                              1 (100%)                 
   Eye                                                (12)                      (5)                       (3)                       
      Lids, Fibroma                                                              1 (20%)                                            
   Harderian Gland                                                              (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (6)          (58)         (7)          (58)         (7)          
      Renal Tubule, Adenoma                                                                                1 (2%)                   
      Transitional Epithelium, Carcinoma                                                                   1 (2%)                   
   Urinary Bladder                                    (59)         (3)          (58)         (3)          (58)         (5)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(59)        *(6)         *(58)        *(7)         *(58)        *(7)          
      Leukemia Mononuclear                            31 (53%)                  32 (55%)                  26 (45%)                  
      Mesothelioma Malignant                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  14                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/M3      0 MG/M3      0.62MGM3     0.62MGM3     1.25MGM3     1.25MGM3        
                                                                LUNGTX                     LUNGTX                    LUNGTX         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            57                      57                      56                           
     Total Primary Neoplasms                          158                     162                     162                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 56                      55                      55                           
     Total Benign Neoplasms                           118                     122                     119                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              37                      38                      35                           
     Total Malignant Neoplasms                         40                      39                      42                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      1                       1                           
     Total Metastatic Neoplasm                                                  3                       1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                       1                           
     Total Uncertain Neoplasms                                                  1                       1                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2.5MG/M3     2.5MG/M3                                                            
                                                                 LUNGTX                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          58            7                                                               
  Scheduled Sacrifice                                  5            7                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                36                                                                            
    Natural Death                                      4                                                                            
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                11                                                                            
  Other                                                1                                                                            
  Animals Examined Microscopically                    57            7                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)                                                                          
   Intestine Large, Cecum                             (56)                                                                          
   Intestine Small, Duodenum                          (57)                                                                          
   Intestine Small, Jejunum                           (57)                                                                          
   Intestine Small, Ileum                             (56)                                                                          
   Liver                                              (57)                                                                          
      Fibrous Histiocytoma, Metastatic                 1 (2%)                                                                       
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                           2 (4%)                                                                       
      Histiocytic Sarcoma, Metastatic, Skin            1 (2%)                                                                       
   Mesentery                                          (1)                                                                           
   Pancreas                                           (57)                                                                          
   Salivary Glands                                    (57)                                                                          
   Stomach, Forestomach                               (57)                                                                          
   Stomach, Glandular                                 (57)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (57)                                                                          
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (57)                                                                          
   Adrenal Medulla                                    (57)                                                                          
      Pheochromocytoma Malignant                       6 (11%)                                                                      
      Pheochromocytoma Benign                         16 (28%)                                                                      
                                                             Page  16                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2.5MG/M3     2.5MG/M3                                                            
                                                                 LUNGTX                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, Pheochromocytoma Benign              16 (28%)                                                                      
   Islets, Pancreatic                                 (57)                                                                          
      Adenoma                                          2 (4%)                                                                       
   Parathyroid Gland                                  (54)                                                                          
   Pituitary Gland                                    (57)                                                                          
      Pars Distalis, Adenoma                          12 (21%)                                                                      
   Thyroid Gland                                      (57)                                                                          
      C-Cell, Adenoma                                  2 (4%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)                                                                           
      Basal Cell Carcinoma                             1 (25%)                                                                      
      Carcinoma, Metastatic, Lung                      1 (25%)                                                                      
      Fibrosarcoma                                     1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (57)                                                                          
   Preputial Gland                                    (56)                                                                          
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Seminal Vesicle                                    (57)                                                                          
   Testes                                             (57)                                                                          
      Bilateral, Interstitial Cell, Adenoma           27 (47%)                                                                      
      Interstitial Cell, Adenoma                      24 (42%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (15)                                                                          
   Lymph Node, Bronchial                              (57)         (7)                                                              
   Lymph Node, Mandibular                             (56)                                                                          
   Lymph Node, Mesenteric                             (56)                                                                          
   Lymph Node, Mediastinal                            (56)         (6)                                                              
   Spleen                                             (57)                                                                          
      Pheochromocytoma Malignant, Metastatic           1 (2%)                                                                       
   Thymus                                             (53)                                                                          
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  17                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2.5MG/M3     2.5MG/M3                                                            
                                                                 LUNGTX                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)                                                                          
   Skin                                               (7)                                                                           
      Keratoacanthoma                                  1 (14%)                                                                      
      Papilloma                                        1 (14%)                                                                      
      Sebaceous Gland, Adenoma                         1 (14%)                                                                      
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (14%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Fibrous Histiocytoma                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                   (1)                                                                           
      Ganglion, Paraganglioma Benign                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (57)         (7)                                                              
      Alveolar/Bronchiolar Adenoma                     2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                                                                       
      Fibrous Histiocytoma, Metastatic                 1 (2%)                                                                       
      Histiocytic Sarcoma, Metastatic, Skin            1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic           1 (2%)                                                                       
   Nose                                               (57)         (7)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)         (7)                                                              
      Histiocytic Sarcoma, Metastatic, Skin            1 (2%)                                                                       
   Urinary Bladder                                    (57)         (4)                                                              
                                                             Page  18                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2.5MG/M3     2.5MG/M3                                                            
                                                                 LUNGTX                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(57)        *(7)                                                              
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            35 (61%)                                                                      
      Mesothelioma Malignant                           2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  19                                                               
NTP Experiment-Test: 05123-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 04:33:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2.5MG/M3     2.5MG/M3                                                            
                                                                 LUNGTX                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            57                                                                           
     Total Primary Neoplasms                          162                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 57                                                                           
     Total Benign Neoplasms                           110                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              43                                                                           
     Total Malignant Neoplasms                         52                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6                                                                           
     Total Metastatic Neoplasm                         19                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  20                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.