National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1373

TDMS Study 05123-05 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                            NICKEL OXIDE


NTP Experiment-Test: 05123-05                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 08/23/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36


                                                       2 YEAR CORE STUDY


       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  001313991

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Merge     002   002,004                  0 MG/M3
                               Merge     006   006,008                  0.62MGM3
                               Merge     010   010,012                  1.25MGM3
                               Merge     014   014,016                  2.5MG/M3
                               Merge     001   001,003                  0 MG/M3
                               Merge     005   005,007                  0.62MGM3
                               Merge     009   009,011                  1.25MGM3
                               Merge     013   013,015                  2.5MG/M3

























                                                             Page   1
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|             
                             DAY ON TEST   | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|             
                                           | 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Chronic Active         |                                        4                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       1        1           3  1     1  3           1  1     1           1|             
      Congestion                           |                                                                          |             
      Cyst                                 | X                                                                        |             
      Eosinophilic Focus                   |                                     1                                    |             
      Fatty Change                         | 2  1     1        2     1        2           4  2           1  2     1   |             
      Granuloma                            |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X                                               X           X   |             
      Mixed Cell Focus                     |                                                                X         |             
      Pigmentation, Bile                   |                   1                                                      |             
      Pigmentation, Hemosiderin            |                         1                                                |             
      Bile Duct, Hyperplasia               |                2        2                                                |             
      Hepatocyte, Hyperplasia              | 2                                2              3                        |             
      Hepatocyte, Necrosis                 |          2        1                             1                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Acinus, Atrophy                      |                1                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Edema                                |                                           3                              |             
      Hyperkeratosis                       |                                        2                                 |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                         +                                                |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                   X                                                      |             
      Vein, Inflammation, Chronic Active   |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Congestion                           |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|             
                             DAY ON TEST   | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|             
                                           | 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cyst                                 | X                                                                        |             
      Degeneration, Fatty                  |                                                 2                        |             
      Degeneration                         |             3                    2                                       |             
      Hemorrhage                           | 3                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                     1                 1  2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Angiectasis           |       4        2           2     1              1                        |             
      Pars Distalis, Cyst                  | X                          X        X                 X                  |             
      Pars Distalis, Hyperplasia           |             3  4                 2              1                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                                               +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |             2     2        2     2                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                             X        X           X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |       1                                                                 1|             
                                            __________________________________________________________________________|             
   Vagina                                  |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Fibrosis                             |                         3                                                |             
      Hyperplasia                          | 3           3     3              3     2                 3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +        +     +              +     +                           |             
      Pigmentation                         |                   1                                                      |             
      Iliac, Hyperplasia, Lymphoid         |                                        4                                 |             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active                           |                                        4                                 |             
      Popliteal, Pigmentation              |                                                                          |             
      Renal, Pigmentation, Hemosiderin     |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +|             
      Congestion                           |                2                                                         |             
      Hyperplasia, Lymphoid                |                                        4                                 |             
      Pigmentation, Hemosiderin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|             
                             DAY ON TEST   | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|             
                                           | 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic Active         |                                        4                                 |             
      Pigmentation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Congestion                           |                      2                                                   |             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Hyperplasia, Plasma Cell             | 2                                                                        |             
      Inflammation, Chronic Active         |                                        4                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 4                        |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |          3              3                                2     4         |             
      Femur, Hyperostosis                  |                2                                3                       4|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      1                                                   |             
      Cerebrum, Compression                |                                           X                          X   |             
      Hypothalamus, Compression            |       X                                                                  |             
      Ventricle, Dilatation                |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2                                                     1            |             
      Inflammation, Chronic Active         |                      1                                                   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                1                                                         |             
      Inflammation, Chronic                |    1                          1              2        1     1  1        1|             
      Inflammation, Chronic Active         |                                        3                                 |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 5| 7| 5| 3| 5| 7|             
                             DAY ON TEST   | 7| 9| 3| 1| 1| 2| 6| 4| 6| 2| 3| 2| 3| 3| 0| 5| 3| 3| 3| 5| 2| 6| 4| 8| 3|             
                                           | 8| 4| 2| 3| 8| 9| 4| 4| 4| 9| 2| 9| 1| 6| 3| 8| 2| 2| 2| 3| 9| 3| 8| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
                                           | 7| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Atypical                        |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                         3                                                |             
      Necrosis                             |                         3                                                |             
      Lens, Cataract                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    1  2  2     1        1  2  3  1  2           2  2  2  1  2  1     2  2|             
      Cortex, Inflammation, Chronic        |                                                       3                  |             
      Cortex, Necrosis, Acute              |                                                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|             
                                           | 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       3     1  1  1              1  3     2  1  3  1  1     1     1     1|             
      Congestion                           |                2                                                         |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                                  1                                       |             
      Fatty Change                         |    2     4     1     2  1  2  3        3                             2   |             
      Granuloma                            |                                                                      2   |             
      Hepatodiaphragmatic Nodule           |                                           X           X              X   |             
      Mixed Cell Focus                     |                                                                          |             
      Pigmentation, Bile                   |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Bile Duct, Hyperplasia               | 2     2                                                                  |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |    1           1                 1                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                    +                                                |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
      Vein, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  1                                       |             
      Atrophy                              |    4                                                                     |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|             
                                           | 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |                1                                                         |             
      Degeneration                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                1                 1  1                                    |             
      Hyperplasia                          | 2                          1                    1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          1               |             
      Pars Distalis, Angiectasis           |                                  1                             4         |             
      Pars Distalis, Cyst                  |                            X        X                             X      |             
      Pars Distalis, Hyperplasia           |    3  4        1                                      1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                             +              +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   2      |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |       1                                               1              1   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 1  1                    2                                                |             
      Hyperplasia                          | 3     2  3           2  2              3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +              +     +        +                                +|             
      Pigmentation                         |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Popliteal, Pigmentation              |                                                                         1|             
      Renal, Pigmentation, Hemosiderin     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |                                           3                              |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|             
                                           | 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +  +  M  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |       3                                                                  |             
      Pigmentation                         |       2                          1                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation                         |                                  1           1                 1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Infarct                              |          4                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                +                 +              +                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
      Femur, Hyperostosis                  |                                     2     2                              |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
      Inflammation, Chronic                |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Cerebrum, Compression                |          X                                   X              X            |             
      Hypothalamus, Compression            |                                                                      X   |             
      Ventricle, Dilatation                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                           2                             1|             
      Inflammation, Chronic Active         |                                              1                           |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic                |       1        1  1              1           1  1     1     1        1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 6| 6| 6| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 1| 9| 3| 2| 3| 3| 1| 5| 4| 5| 0| 3| 3| 2| 3| 1| 3| 6| 3| 1| 6| 2| 9| 4| 3|             
                                           | 3| 9| 2| 7| 0| 0| 4| 4| 3| 5| 7| 2| 1| 4| 2| 4| 2| 8| 2| 5| 8| 2| 2| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Atypical                        |                                                       3                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Lens, Cataract                       |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  3  1     3  3  3                 1  2  1  2  3     2  2  1     1  2  3|             
      Cortex, Inflammation, Chronic        |                                                                          |             
      Cortex, Necrosis, Acute              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 2| 8|                                                                 |            |
                                           | 2| 7| 9|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    0 MG/M3                                | 2| 2| 3|                                                                 |      L     |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |    X                                                                     |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Basophilic Focus                     | 1  1                                                                     |     26  1.4|
      Congestion                           | 2                                                                        |      2  2.0|
      Cyst                                 |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      2  1.0|
      Fatty Change                         |       3                                                                  |     21  2.0|
      Granuloma                            |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           | X                                                                        |      7     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Pigmentation, Bile                   |                                                                          |      1  1.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      4  2.0|
      Hepatocyte, Hyperplasia              | 3                                                                        |      4  2.5|
      Hepatocyte, Necrosis                 |                                                                          |      6  1.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
      Edema                                |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Atrium, Thrombosis                   |                                                                          |      1     |
      Vein, Inflammation, Chronic Active   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 2| 8|                                                                 |            |
                                           | 2| 7| 9|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    0 MG/M3                                | 2| 2| 3|                                                                 |      L     |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  1.0|
      Atrophy                              |                                                                          |      1  4.0|
      Congestion                           |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  |                                                                          |      2  1.5|
      Degeneration                         |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  51        |
      Angiectasis                          |                                                                          |      3  1.0|
      Hyperplasia                          |    1  1                                                                  |      8  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      1  1.0|
      Pars Distalis, Angiectasis           |                                                                          |      7  2.1|
      Pars Distalis, Cyst                  | X                                                                        |      8     |
      Pars Distalis, Hyperplasia           |       3                                                                  |      9  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  2.0|
      Ectasia                              |    2                                                                     |      5  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  52        |
      Fibrosis                             |       2                                                                  |      5  1.8|
      Hyperplasia                          | 2     3                                                                  |     14  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                                                                  |  14        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 2| 8|                                                                 |            |
                                           | 2| 7| 9|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    0 MG/M3                                | 2| 2| 3|                                                                 |      L     |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |                                                                          |      1  1.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Pancreatic, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
      Popliteal, Pigmentation              |                                                                          |      1  1.0|
      Renal, Pigmentation, Hemosiderin     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  49        |
      Congestion                           |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  47        |
      Hyperplasia, Lymphoid                |    3                                                                     |      3  3.0|
      Pigmentation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +                                                                  |  51        |
      Congestion                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  48        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Osteopetrosis                        |                                                                          |      4  3.0|
      Femur, Hyperostosis                  |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 2| 8|                                                                 |            |
                                           | 2| 7| 9|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    0 MG/M3                                | 2| 2| 3|                                                                 |      L     |
                                           | 8| 9| 0|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Cerebrum, Compression                |                                                                          |      5     |
      Hypothalamus, Compression            |                                                                          |      2     |
      Ventricle, Dilatation                |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
      Inflammation, Chronic                |                                                                          |      4  1.5|
      Inflammation, Chronic Active         |    1                                                                     |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  1.0|
      Inflammation, Chronic                |    1                                                                     |     18  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Atypical                        |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   3        |
      Hemorrhage                           |       4                                                                  |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Lens, Cataract                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Nephropathy                          |    1  2                                                                  |     36  1.8|
      Cortex, Inflammation, Chronic        |                                                                          |      1  3.0|
      Cortex, Necrosis, Acute              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|             
                                           | 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1  1        2     3  1  1     2  1  1  1  2  1  2  1     1  2  1  2  1   |             
      Clear Cell Focus                     |                                        1                                 |             
      Congestion                           |                         1                                                |             
      Degeneration, Cystic                 |                                                                      1   |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |       2        2           1     1  2                 2                 1|             
      Fibrosis                             |                1                                                         |             
      Hemorrhage                           |          2                                                               |             
      Hepatodiaphragmatic Nodule           |                                                 X                    X   |             
      Pigmentation, Bile                   |       2                                                                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Bile Duct, Hyperplasia               |          2                                                               |             
      Hepatocyte, Hyperplasia              |          3                 2                                             |             
      Hepatocyte, Necrosis                 |          2     2                                                  1      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Polyarteritis                 |                                                                          |             
      Mesenteric Artery, Polyarteritis     |                                                                          |             
      Mesenteric Artery, Thrombosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|             
                                           | 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                          2               |             
      Congestion                           |                            2                                             |             
      Degeneration, Fatty                  |             4                                                            |             
      Hyperplasia                          |                                                                          |             
      Bilateral, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Congestion                           |                            2                                             |             
      Hyperplasia                          |                         2              1              3  3  1        1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Angiectasis           |             3                                            2               |             
      Pars Distalis, Cyst                  |          X  X        X                                         X        X|             
      Pars Distalis, Degeneration          |                                                                          |             
      Pars Distalis, Hyperplasia           |             3  3                                         3  3            |             
      Pars Intermedia, Angiectasis         |                                                             2            |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hypertrophy         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                     4                          2         |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                         4                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                                            X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       4                                                                  |             
      Hyperplasia                          |          4     4                                      2     3     3     3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|             
                                           | 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +     +                                                         |             
      Hyperplasia, Lymphoid                |       1                                                                  |             
      Renal, Congestion                    |       1  2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  I  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                         1|             
      Hyperplasia, Lymphoid                |                                                    1              2      |             
      Hyperplasia, Macrophage              |                      3                                                   |             
      Pigmentation                         | 1  1     1  2     2           2     1  2  2     2  1  2        2  1  1  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Congestion                           |                            2                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                               2                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  I  +  +  +  M  M  +  M  +  +  +  +  +  M  +  M  +|             
      Congestion                           |                                                    2  2                  |             
      Hyperplasia, Lymphoid                |             1                                      2  2           2      |             
      Pigmentation                         |       1  1  2     1  2           2        1              1  2     1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  1                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                       +                  |             
      Inflammation, Suppurative            |                                                       4                  |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                      4  2|             
      Femur, Hyperostosis                  |             2                                   2                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Compression              |    X                                                                     |             
      Cerebrum, Compression                | X  X                                X                                    |             
      Hypothalamus, Compression            |                                                                          |             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 1| 3| 7| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 7|             
                                           | 9| 4| 6| 8| 1| 2| 1| 0| 9| 6| 9| 2| 9| 1| 0| 2| 2| 0| 7| 0| 0| 2| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                                           | 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  2                                       |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1  1  1  1  2  1  2  2  2  1  2  2  1  2  2  2  2  2  2  1  2  2  2  2  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                                                                2         |             
      Alveolus, Pigmentation               | 1  2  1  1  2  1  2  2  2  1  2  2  1  2  2  2  2  2  2  2  2  2  2  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             1            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 3  1     3  2     1  1  3  3  2  1  1  1  2  2  2        3  2  1  2  1  1|             
      Cortex, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|             
                                           | 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                1                              |             
      Basophilic Focus                     | 2  1  1     1  1     3  1           2  1  1  2  1     2  2  1  1         |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |             1  1                                                         |             
      Fatty Change                         |       1  3        3        1  3  2     1           2           2  3  1   |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Pigmentation, Bile                   |                                                                          |             
      Pigmentation, Hemosiderin            |                                  2                                       |             
      Bile Duct, Hyperplasia               |       1                                                        2         |             
      Hepatocyte, Hyperplasia              |                      2        3              2                          2|             
      Hepatocyte, Necrosis                 |       1                       2              1     2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             1           1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          3                                                               |             
      Ulcer                                |          3     3                                                  2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   1      |             
      Ulcer                                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
      Aorta, Polyarteritis                 |                            4                                             |             
      Mesenteric Artery, Polyarteritis     |                            X                                             |             
      Mesenteric Artery, Thrombosis        |                            X                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|             
                                           | 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                           1     2                        |             
      Congestion                           |                                                                   2      |             
      Degeneration, Fatty                  |                                                             2     2      |             
      Hyperplasia                          |                               3                                          |             
      Bilateral, Angiectasis               |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                4              2           1                       4  3  3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 1                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Pars Distalis, Angiectasis           | 2                    2                       2                           |             
      Pars Distalis, Cyst                  |                   X           X              X                           |             
      Pars Distalis, Degeneration          |                   1                                                      |             
      Pars Distalis, Hyperplasia           | 3              2     2  4                                            2  4|             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                      X                                                   |             
      Pars Intermedia, Hypertrophy         |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Cystic                  |                                                 3                        |             
      Inflammation, Chronic Active         |          2                                                               |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X  X                                               X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      3                                                   |             
      Endometrium, Hyperplasia, Cystic     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          1                    2                                          |             
      Hyperplasia                          |                   3           2  2           2     2        2  3  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|             
                                           | 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +                 +                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Renal, Congestion                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2                                                  2      |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                     2        2                           |             
      Hyperplasia, Macrophage              |                                                                          |             
      Pigmentation                         | 1  1  1  2  2  2     2  1  2  1  1  2  1  2  1  2  2  2  2  1  1  1  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | I  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  I|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           2           2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Congestion                           |                3                                   1              4      |             
      Hyperplasia, Lymphoid                | 2           1        2     2                 2                           |             
      Pigmentation                         | 2  1  1  2  2     1  2     2  1  1  1  2     1  1  2  2  1  1  2  1     2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      2                                         2         |             
      Hematopoietic Cell Proliferation     |                                        4                                 |             
      Infarct                              |                                                                   2      |             
      Necrosis                             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |             2                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    |                            +  +                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Subcutaneous Tissue, Edema           |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Compression              |                                                                          |             
      Cerebrum, Compression                |             X                                                            |             
      Hypothalamus, Compression            |                                                          X               |             
      Ventricle, Dilatation                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 7| 4| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 7| 6| 2| 2| 0| 2| 3| 7| 2| 1| 2| 2| 3| 2| 3| 2| 5| 2| 3| 3| 6| 6| 0| 2|             
                                           | 0| 5| 0| 2| 5| 3| 3| 0| 2| 1| 9| 4| 9| 4| 9| 1| 9| 2| 9| 1| 1| 8| 7| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.62MGM3                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    1                     |             
      Inflammation, Suppurative            |                1                                                         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  1  2  1  2     1  1  1  2  2  1  2  2  2  2  2  2  2  2  2  2  1  2  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                                                                          |             
      Alveolus, Pigmentation               | 2  1  2  2  2     1  1  1  2  1  1  2  2  2  2  2  1  2  2  2  1  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                       1                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +              +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2        4  3  1     2     2  1     3  1  1  2  2  2  2  2  1  1  3     2|             
      Cortex, Inflammation, Chronic        |    1                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 0| 0| 7|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    0.62MGM3                               | 5| 5| 5|                                                                 |      L     |
                                           | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |       X                                                                  |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      2  1.0|
      Basophilic Focus                     | 1  1  1                                                                  |     38  1.4|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Congestion                           |                                                                          |      1  1.0|
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |    1                                                                     |      3  1.0|
      Fatty Change                         |                                                                          |     18  1.8|
      Fibrosis                             |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Pigmentation, Bile                   |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      3  1.7|
      Hepatocyte, Hyperplasia              |                                                                          |      6  2.3|
      Hepatocyte, Necrosis                 |                                                                          |      7  1.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  M                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Polyarteritis                 |                                                                          |      1  4.0|
      Mesenteric Artery, Polyarteritis     |                                                                          |      1     |
      Mesenteric Artery, Thrombosis        |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 0| 0| 7|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    0.62MGM3                               | 5| 5| 5|                                                                 |      L     |
                                           | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      3  1.7|
      Congestion                           |                                                                          |      2  2.0|
      Degeneration, Fatty                  |                                                                          |      3  2.7|
      Hyperplasia                          |                                                                          |      1  3.0|
      Bilateral, Angiectasis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |     12  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |    2                                                                     |      6  2.2|
      Pars Distalis, Cyst                  |                                                                          |      8     |
      Pars Distalis, Degeneration          |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |    1                                                                     |     11  2.7|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
      Pars Intermedia, Hypertrophy         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Ectasia                              | 2                                                                        |      3  2.7|
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 0| 0| 7|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    0.62MGM3                               | 5| 5| 5|                                                                 |      L     |
                                           | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Dilatation                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      3  2.3|
      Hyperplasia                          |                                                                          |     15  2.6|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Renal, Congestion                    |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  50        |
      Congestion                           |                                                                          |      2  2.0|
      Edema                                |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                | 1                                                                        |      5  1.6|
      Hyperplasia, Macrophage              |                                                                          |      1  3.0|
      Pigmentation                         | 2  2  1                                                                  |     43  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M                                                                  |  45        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Pigmentation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  46        |
      Congestion                           |                                                                          |      5  2.4|
      Hyperplasia, Lymphoid                |                                                                          |      9  1.8|
      Pigmentation                         | 2  2  1                                                                  |     34  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      3  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Hyperplasia, Glandular               |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 0| 0| 7|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    0.62MGM3                               | 5| 5| 5|                                                                 |      L     |
                                           | 7| 8| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   3        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Osteopetrosis                        |                                                                          |      2  3.0|
      Femur, Hyperostosis                  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Cerebellum, Compression              |                                                                          |      1     |
      Cerebrum, Compression                |                                                                          |      4     |
      Hypothalamus, Compression            |                                                                          |      1     |
      Ventricle, Dilatation                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Inflammation, Chronic                | 2  2  2                                                                  |     52  1.7|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Atypical                        |                                                                          |      1  2.0|
      Alveolus, Pigmentation               | 2  2  2                                                                  |     52  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Nephropathy                          | 2  3  1                                                                  |     43  1.9|
      Cortex, Inflammation, Chronic        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|             
                                           | 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                          3               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Parasite Metazoan                    |                   X                                            X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 3     2  1  1  1           1  2        2  1  2  1  2  3              3  1|             
      Congestion                           |                                              2                           |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |             1                             1                    1         |             
      Fatty Change                         |                   3  3              2                       2     2      |             
      Hepatodiaphragmatic Nodule           |    X  X  X                             X                       X        X|             
      Thrombosis                           |                                     X                                    |             
      Bile Duct, Hyperplasia               |    2                             4                                       |             
      Hepatocyte, Hyperplasia              |                   2                                                      |             
      Hepatocyte, Necrosis                 |                            1     3                                       |             
      Portal Vein, Thrombosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         1                                                |             
      Artery, Mineralization               |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                           4                 2     4      |             
      Inflammation, Chronic                |                                           3                              |             
      Inflammation, Chronic Active         |                                                                   3      |             
      Mineralization                       |                                                          2               |             
      Ulcer                                |                                           3                       2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                  2                                       |             
      Mineralization                       |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +                       +               |             
      Aorta, Mineralization                |                                                          4               |             
      Vena Cava, Mineralization            |                                                          4               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|             
                                           | 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Ventricle, Mineralization            |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            1                                             |             
      Congestion                           |                            2                                             |             
      Degeneration, Fatty                  |                            1           2              1  1               |             
      Edema                                |                2                                                         |             
      Hemorrhage                           |                   3                                                      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4  1                             1        2           4           1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2     2     2                             3                              |             
      Pars Distalis, Cyst                  |       X        X        X  X  X              X                           |             
      Pars Distalis, Hyperplasia           | 2           3                             2                              |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                           2     2                    2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                            +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    1                                               1                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X           X           X        X              X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Prolapse                             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                           3              3               |             
      Hyperplasia                          |    2           2     2           2  2              2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                 +           +  +        +                           |             
      Pancreatic, Hyperplasia, Lymphoid    |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|             
                                           | 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                   3                                                      |             
      Hyperplasia, Lymphoid                |                1                    1  2        2  1  2     1  2     2  2|             
      Pigmentation                         | 2  2  1  1  2  2  2  2  2  2  2  1  1     2  1  2  2  2  2  2  2  1  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2     2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Congestion                           |       2                 3     3                                          |             
      Ectasia                              |                         3                                                |             
      Edema                                |                   2                                                      |             
      Hyperplasia, Lymphoid                |             2  2           2        2  1     3              1            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation, Hemosiderin            |       2                                                                  |             
      Pigmentation                         |          2  2  2  2  1  2  2  2  1  2  2     2        2     2  2  1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2              2                                                      |             
      Hemorrhage                           |                   1                                                      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Femur, Hyperostosis                  |          4        3     4                       2              3        3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Compression              |                                                                          |             
      Cerebrum, Compression                |                                                                   X      |             
      Cerebrum, Ventricle, Dilatation      |                                                                   2     1|             
      Hypothalamus, Compression            |                               X                       X                  |             
      Pons, Compression                    |                                                       X                  |             
      Ventricle, Dilatation                |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 6| 7| 7| 7| 7| 7| 6| 6| 4| 5| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 2| 3| 3| 9| 4| 3| 3| 3| 9| 9| 9| 1| 3| 3| 2| 3| 3| 1| 7| 3| 4| 4|             
                                           | 1| 2| 1| 9| 1| 1| 0| 3| 0| 2| 0| 0| 4| 0| 3| 1| 1| 7| 1| 8| 8| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 6| 7| 8| 0| 1| 4| 5| 6| 7| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          2               |             
      Inflammation, Chronic Active         |                                                                2         |             
      Inflammation, Suppurative            |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                | 3  2  3  2  2  3  3  2  2  2  2  2  2  3  3  2  2  3  2  2  3  3  3  3  3|             
      Mineralization                       |                                                          3               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                1                             2                           |             
      Alveolus, Pigmentation               | 2  2  2  2  2  2  2  2  2  2  2  1  1  2  3  2  2  3  2  3  2  3  3  2  2|             
      Pleura, Fibrosis                     |                   3                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          3               |             
      Inflammation, Suppurative            |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +        +                    +     +         |             
      Cataract                             |                            4                                   2         |             
      Synechia                             |                            4                                             |             
      Bilateral, Cornea, Edema             |                                                                          |             
      Cornea, Edema                        |                                                          1     2         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
      Nephropathy                          | 1  1  2  1  1  2  1     2  2  2  1  1  2  4  2  1     3  4        3     1|             
      Pelvis, Dilatation                   |                                           1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|             
                                           | 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Basophilic Focus                     |    2     1     2  1  1     1  1  1     1           1  1              2   |             
      Congestion                           |                      1        2                                          |             
      Degeneration, Cystic                 |             1                                   3                        |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         | 2           2           3           1     2  1  3           2            |             
      Hepatodiaphragmatic Nodule           |                      X                    X                          X   |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Hyperplasia              |                                     2                                    |             
      Hepatocyte, Necrosis                 |                         1                                                |             
      Portal Vein, Thrombosis              |             X                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Artery, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                 1                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
      Vena Cava, Mineralization            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|             
                                           | 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Ventricle, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3              2                                                   |             
      Congestion                           |                2                                                         |             
      Degeneration, Fatty                  |                                                       3                  |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2  1           2        4           4        2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    3                                                              2      |             
      Pars Distalis, Cyst                  | X           X                       X                                   X|             
      Pars Distalis, Hyperplasia           |             3                       2                             2      |             
      Pars Intermedia, Angiectasis         |                                                       3                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               2                                      4   |             
      Inflammation, Suppurative            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Prolapse                             |          X                                                               |             
      Endometrium, Hyperplasia, Cystic     |                2        1                                                |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             1            |             
      Hyperplasia                          | 2        3  2           2           2  3        2           1            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                   +                       +            |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|             
                                           | 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2                                       |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |    1        2        2           2        1                    1  1  1  1|             
      Pigmentation                         | 2  2  2  2  1  2  2  1  1  2  2  2  2  2  2  2  2  1  2  2  2  2  1  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      1                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                 2                 1              1         |             
      Ectasia                              |                                                                          |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |       2  2     2  2           3  3        1                              |             
      Hyperplasia, Plasma Cell             |                      2                                                   |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pigmentation                         | 2     2  2  1  2  2  2  2     2  2  2  1  2  2  2  2  2  2  2  2  1  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2                                                |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Capsule, Fibrosis                    |                                              2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                   +        +                                            +|             
      Subcutaneous Tissue, Fibrosis        |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                      1   |             
      Femur, Hyperostosis                  |                   2        4                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Compression              |                                                                      X   |             
      Cerebrum, Compression                |                                                          X           X   |             
      Cerebrum, Ventricle, Dilatation      |                                                                          |             
      Hypothalamus, Compression            |                X                                                         |             
      Pons, Compression                    |                                                                          |             
      Ventricle, Dilatation                |                2                                                         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 3| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 4| 5| 7| 5| 6| 7| 6| 5| 4| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 4| 3| 2| 1| 3| 5| 3| 3| 2| 2| 3| 7| 0| 2| 9| 4| 1| 8| 6| 6| 2| 1|             
                                           | 9| 0| 0| 6| 0| 9| 4| 2| 5| 4| 0| 9| 9| 2| 1| 3| 7| 4| 7| 3| 6| 5| 6| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             1            |             
      Inflammation, Chronic Active         |       2                                                                  |             
      Inflammation, Suppurative            |                                                          1               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          3               |             
      Hemorrhage                           |                                           3              2               |             
      Inflammation, Chronic                | 3  2  2  2  2  2  3  2  2  3  2  2  2  2  2  2  3  2  3  2  2  2  2  3  2|             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |    2                 4                 3                       3         |             
      Alveolus, Pigmentation               | 2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2|             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3     1                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      1   |             
      Inflammation, Suppurative            |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Synechia                             |                                                                          |             
      Bilateral, Cornea, Edema             |                                                                          |             
      Cornea, Edema                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          |    2  2        3     2  2  3  2  2  2  1     1  1        2  1        3   |             
      Pelvis, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                      X   |             
      Edema                                |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4|                                                                 |            |
                             DAY ON TEST   | 1| 2| 3|                                                                 |            |
                                           | 4| 7| 6|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 8| 8| 8|                                                                 |      L     |
                                           | 6| 7| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |     27  1.5|
      Congestion                           |                                                                          |      3  1.7|
      Degeneration, Cystic                 |                                                                          |      2  2.0|
      Eosinophilic Focus                   |                                                                          |      3  1.0|
      Fatty Change                         | 3  2  1                                                                  |     16  2.1|
      Hepatodiaphragmatic Nodule           |                                                                          |      9     |
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Hyperplasia               |    2                                                                     |      3  2.7|
      Hepatocyte, Hyperplasia              | 2                                                                        |      3  2.0|
      Hepatocyte, Necrosis                 |                                                                          |      3  1.7|
      Portal Vein, Thrombosis              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  1.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperkeratosis                       |                                                                          |      4  2.8|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4|                                                                 |            |
                             DAY ON TEST   | 1| 2| 3|                                                                 |            |
                                           | 4| 7| 6|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 8| 8| 8|                                                                 |      L     |
                                           | 6| 7| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
      Vena Cava, Mineralization            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Atrium, Thrombosis                   |                                                                          |      1     |
      Ventricle, Mineralization            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      3  2.0|
      Congestion                           |                                                                          |      2  2.0|
      Degeneration, Fatty                  |                                                                          |      5  1.6|
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |    2                                                                     |     14  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +                                                                  |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Pars Distalis, Angiectasis           |                                                                          |      6  2.3|
      Pars Distalis, Cyst                  | X                                                                        |     11     |
      Pars Distalis, Hyperplasia           |                                                                          |      6  2.3|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +                                                                  |  51        |
      Ectasia                              |    2                                                                     |      5  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      7     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4|                                                                 |            |
                             DAY ON TEST   | 1| 2| 3|                                                                 |            |
                                           | 4| 7| 6|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 8| 8| 8|                                                                 |      L     |
                                           | 6| 7| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Prolapse                             |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      3  2.3|
      Hyperplasia                          | 2                                                                        |     15  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   9        |
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |       1                                                                  |     20  1.5|
      Pigmentation                         | 2  2  2                                                                  |     52  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +                                                                  |  48        |
      Congestion                           |                                                                          |      7  2.1|
      Ectasia                              |                                                                          |      1  3.0|
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |     14  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Pigmentation                         |       1                                                                  |     39  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |       3                                                                  |      1  3.0|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +                                                                  |  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   3        |
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4|                                                                 |            |
                             DAY ON TEST   | 1| 2| 3|                                                                 |            |
                                           | 4| 7| 6|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 8| 8| 8|                                                                 |      L     |
                                           | 6| 7| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Hyperostosis                         |    4                                                                     |      2  2.5|
      Femur, Hyperostosis                  | 2     2                                                                  |     10  2.9|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Cerebellum, Compression              |                                                                          |      1     |
      Cerebrum, Compression                |                                                                          |      3     |
      Cerebrum, Ventricle, Dilatation      |                                                                          |      2  1.5|
      Hypothalamus, Compression            |                                                                          |      3     |
      Pons, Compression                    |                                                                          |      1     |
      Ventricle, Dilatation                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Chronic                | 3  3  2                                                                  |     53  2.4|
      Mineralization                       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Atypical                        |                                                                          |      6  2.5|
      Alveolus, Pigmentation               | 2  2  2                                                                  |     53  2.1|
      Pleura, Fibrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  52        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   5        |
      Cataract                             |                                                                          |      2  3.0|
      Synechia                             |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4|                                                                 |            |
                             DAY ON TEST   | 1| 2| 3|                                                                 |            |
                                           | 4| 7| 6|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 8| 8| 8|                                                                 |      L     |
                                           | 6| 7| 9|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Cornea, Edema             | 1                                                                        |      1  1.0|
      Cornea, Edema                        |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Cyst                                 |    X                                                                     |      2     |
      Nephropathy                          |                                                                          |     35  1.9|
      Pelvis, Dilatation                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Edema                                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 0| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 3| 7| 3| 9| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9|             
                                           | 2| 1| 2| 0| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    2  1     1  1  2        2     4  1     4     1  1  1  2  2  1  1      |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                1     1  2                          1                 2  2|             
      Hepatodiaphragmatic Nodule           |                                     X        X                          X|             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Bile                   |                2                                                         |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Hyperplasia              |    2                          3                       2  1               |             
      Hepatocyte, Necrosis                 |    2                       1                 1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          1                                                               |             
      Inflammation, Chronic                |                                        3                                 |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +                           |             
      Inflammation, Suppurative            |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2                    3                                      3  2      |             
      Degeneration, Fatty                  |                         1        3                 1     2        2      |             
      Edema                                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                           2                              |             
      Hyperplasia                          |    2  4     2              2  1  2  4  1  2  3  4  1           3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 0| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 3| 7| 3| 9| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9|             
                                           | 2| 1| 2| 0| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               3           1                              |             
      Pars Distalis, Cyst                  |    X  X                 X                                         X     X|             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                2  2                       2  3        1  2           2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                   +      |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Ectasia                              |                               2                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                         X                        |             
      Fibrosis                             |                                                    3                     |             
      Hemorrhage                           |                                                    2                     |             
      Bilateral, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                    4                     |             
      Endometrium, Hyperplasia, Cystic     |                         2                       3     1  1  1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                2                                   2  2  2           2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                    +                 +   |             
      Renal, Edema                         |                                                    3                     |             
      Renal, Pigmentation                  |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |    1     3        2                                1                     |             
      Hyperplasia, Macrophage              |                                                                2         |             
      Pigmentation                         | 2  2  2     2     1     2  2  2  1  2  2  2  2  2  1  2  2  2     2  2  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |          4                       2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    3                                               1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 0| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 3| 7| 3| 9| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9|             
                                           | 2| 1| 2| 0| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                    1           2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                      2   |             
      Hyperplasia, Lymphoid                |       2              2           2                                       |             
      Pigmentation                         | 1  2  2     2  1     2  2  2  2  2  2  2  2  2        2  2     2     2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +                       +  +                 +              +         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                   3     4                             2        3     2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Compression                | X                                      X                                 |             
      Cerebrum, Ventricle, Dilatation      |                            2           2                                 |             
      Hypothalamus, Compression            |                            X                    X                        |             
      Ventricle, Dilatation                |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                       1                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                             X            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                | 2  3  2  2  2  3  2  2  3  2  2  2  2  2  2  3  2  3  3  3  2  2  3  2  3|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                   2                                      1     2         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Pigmentation               | 2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 0| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 3| 7| 3| 9| 2| 5| 2| 6| 7| 1| 3| 3| 3| 0| 2| 1| 3| 6| 3| 3| 3| 3| 1| 7| 9|             
                                           | 2| 1| 2| 0| 9| 5| 9| 7| 0| 8| 1| 1| 2| 9| 9| 9| 2| 4| 0| 0| 2| 0| 8| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|             
                                           | 7| 8| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  1  2     3     1        3     2  1  2  1     2  2  2  2  1  2  1  1   |             
      Pelvis, Cyst                         |          X                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3|             
                                           | 1| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.5MG/M3                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                            X           X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                                                                  |             
      Basophilic Focus                     | 2  1     3        1  1        1  1     2  3        1  1     1  1  1  1  2|             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                   1  1   |             
      Fatty Change                         |    2        1  1           1     1  2                 2  1               |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Inflammation, Chronic                |                                              1                           |             
      Pigmentation, Bile                   |                                                                          |             
      Bile Duct, Hyperplasia               |                                                       2                  |             
      Hepatocyte, Hyperplasia              |    2                                         1              2            |             
      Hepatocyte, Necrosis                 |    2                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |    2              1                 2                                    |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                       2                  |             
      Atrium, Thrombosis                   |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  |                   2                             1           1            |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          | 2  3                 3     1           3        2              4  3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3|             
                                           | 1| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.5MG/M3                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3        2                                                               |             
      Pars Distalis, Cyst                  |                   X  X                       X                           |             
      Pars Distalis, Hemorrhage            |                                                    3     2               |             
      Pars Distalis, Hyperplasia           | 4        2                       4                    3                 2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +                                       |             
      Abscess                              |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2              2     2                              |             
      Duct, Ectasia                        |                                                    4                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        X                                 |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Bilateral, Cyst                      |                                           X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                      2                                         2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |             2                 2  1              2  2  2  2              4|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                         +|             
      Renal, Edema                         |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Congestion                           |                         2                                3               |             
      Hyperplasia, Lymphoid                | 2        2        1  1                    1     1     2                  |             
      Hyperplasia, Macrophage              |                                                                          |             
      Pigmentation                         | 2  2  2  2  1  2  1  2  2  2     1  2  1  2  2  2     2  2  2     2  2  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
      Hyperplasia, Lymphoid                |                   4                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3|             
                                           | 1| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.5MG/M3                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          4               |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |    2  2  2  1     3              1           2           3     3         |             
      Pigmentation                         | 2  2  2  2  2  1  1  2     2  2  2  2  1  2  2  2  2     2  1  2  2  1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                  4                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                  3                             1         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Compression                |    X           X                                                         |             
      Cerebrum, Ventricle, Dilatation      |    2           2           2                                             |             
      Hypothalamus, Compression            |       X                                                        X         |             
      Ventricle, Dilatation                |       3                                                        2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              1                 2         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          4               |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                         4                                4               |             
      Inflammation, Chronic                | 3  3  3  2  2  2  2  2  3  3  3  3  2  2  3  3  3  3  3  2  2  2  2  2  3|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                                              1                       1   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                  2                                       |             
      Alveolus, Pigmentation               | 2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 5| 7| 5| 5| 6| 6| 4| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 0| 5| 2| 5| 7| 3| 6| 6| 2| 2| 3| 3| 2| 3| 1| 3| 3| 2| 2| 3|             
                                           | 1| 6| 0| 1| 9| 0| 9| 9| 0| 7| 6| 3| 6| 9| 9| 1| 8| 5| 3| 9| 1| 1| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2.5MG/M3                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 5| 7| 9| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +     +            |             
      Cataract                             |                                                       3     4            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2  3  1  1  1     1     2  1  2     1  2  2     1  3     3  3  2  3  1|             
      Pelvis, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7|                                                              |            |
                             DAY ON TEST   | 9| 0| 0| 3|                                                              |            |
                                           | 4| 7| 4| 0|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5|                                                              |      A     |
    2.5MG/M3                               | 1| 1| 1| 2|                                                              |      L     |
                                           | 7| 8| 9| 0|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  54        |
      Parasite Metazoan                    |          X                                                               |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  54        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |    1     1                                                               |     34  1.5|
      Degeneration, Cystic                 |       1                                                                  |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      2  1.0|
      Fatty Change                         |       2                                                                  |     15  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Pigmentation, Bile                   |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Hepatocyte, Hyperplasia              |          3                                                               |      8  2.0|
      Hepatocyte, Necrosis                 |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  54        |
      Hyperkeratosis                       |                                                                          |      4  1.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  54        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +                                                               |  54        |
      Congestion                           |                                                                          |      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7|                                                              |            |
                             DAY ON TEST   | 9| 0| 0| 3|                                                              |            |
                                           | 4| 7| 4| 0|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5|                                                              |      A     |
    2.5MG/M3                               | 1| 1| 1| 2|                                                              |      L     |
                                           | 7| 8| 9| 0|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Degeneration, Fatty                  |                                                                          |      8  1.6|
      Edema                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +                                                               |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |          4                                                               |     22  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  54        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +                                                               |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  54        |
      Pars Distalis, Angiectasis           | 2                                                                        |      5  2.2|
      Pars Distalis, Cyst                  |    X                                                                     |      9     |
      Pars Distalis, Hemorrhage            |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia           |                                                                          |     12  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  53        |
      C-Cell, Hyperplasia                  |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +                                                               |  50        |
      Ectasia                              |                                                                          |      4  2.0|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +                                                               |  54        |
      Cyst                                 |                                                                          |      3     |
      Fibrosis                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Bilateral, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +                                                               |  54        |
      Dilatation                           |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  54        |
      Fibrosis                             |       1                                                                  |      1  1.0|
      Hyperplasia                          |    3  2  2                                                               |     16  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Renal, Edema                         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7|                                                              |            |
                             DAY ON TEST   | 9| 0| 0| 3|                                                              |            |
                                           | 4| 7| 4| 0|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5|                                                              |      A     |
    2.5MG/M3                               | 1| 1| 1| 2|                                                              |      L     |
                                           | 7| 8| 9| 0|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Pigmentation                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +                                                               |  52        |
      Congestion                           |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |    3     2                                                               |     13  1.7|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
      Pigmentation                         | 2  2  2  2                                                               |     47  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +                                                               |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Pigmentation                         |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +                                                               |  50        |
      Congestion                           |                                                                          |      1  4.0|
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |    2     2                                                               |     14  2.1|
      Pigmentation                         |    2  2  2                                                               |     44  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  54        |
      Fibrosis                             |          1                                                               |      1  1.0|
      Hyperplasia                          |    3                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +                                                               |  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  54        |
      Femur, Hyperostosis                  |       1                                                                  |      8  2.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  54        |
      Cerebrum, Compression                |       X                                                                  |      5     |
      Cerebrum, Ventricle, Dilatation      |                                                                          |      5  2.0|
      Hypothalamus, Compression            |          X                                                               |      5     |
      Ventricle, Dilatation                |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +                                                               |  54        |
      Inflammation, Chronic                |                                                                          |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7|                                                              |            |
                             DAY ON TEST   | 9| 0| 0| 3|                                                              |            |
                                           | 4| 7| 4| 0|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5|                                                              |      A     |
    2.5MG/M3                               | 1| 1| 1| 2|                                                              |      L     |
                                           | 7| 8| 9| 0|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  54        |
      Congestion                           |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  4.0|
      Inflammation, Chronic                | 2  2  2  2                                                               |     54  2.4|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Atypical                        |                                                                          |      5  1.4|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolus, Pigmentation               | 2  2  2  2                                                               |     54  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  54        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  54        |
      Nephropathy                          |       2  3                                                               |     40  1.8|
      Pelvis, Cyst                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  54        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|             
                                           | 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          1  1  1     2  1     1     3                    1     1        1|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |    1     2  2     2  2  1  1     3  2                                   1|             
      Eosinophilic Focus                   |                                                          1               |             
      Fatty Change                         | 1              1                          2  1                    3      |             
      Hepatodiaphragmatic Nodule           |          X                                      X        X               |             
      Inflammation, Suppurative            |                                                                   2      |             
      Pigmentation, Bile                   |                                                                          |             
      Thrombosis                           |                                                                          |             
      Thrombosis, Multiple                 |                                                                          |             
      Bile Duct, Hyperplasia               |       3              2           2                          2           1|             
      Hepatocyte, Hyperplasia              |                      2                                                  1|             
      Hepatocyte, Necrosis                 |                                                                         1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Acinus, Atrophy                      |                   2           1                          1               |             
      Acinus, Fibrosis                     |                                                                          |             
      Acinus, Hyperplasia                  |                   2                             1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    2                     |             
      Inflammation, Suppurative            |                            2                                             |             
      Ulcer                                |                                                                          |             
      Ulcer, Multiple                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            2                                             |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                  +      |             
      Aorta, Mineralization                |                2                                                  4      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|             
                                           | 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |       X                                                                  |             
      Myocardium, Mineralization           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                         1                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                          4               |             
      Hyperplasia                          |          4     2        1     2  2  1     2  4  1        4  2  1        1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia           |          1     1  1                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                    +                     |             
      Oral, Inflammation, Chronic Active   |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +                                                  +                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            | 1                                                  3                     |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                              X                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               3                                   1      |             
      Inflammation, Suppurative            |                2              3                                   2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         3        2                                       |             
      Inflammation, Suppurative            |                            2                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                           2                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3  4  3     4  4        2                                3     3|             
      Interstitial Cell, Hyperplasia       |                                                                      1  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|             
                                           | 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                1                                                  2      |             
      Hyperplasia                          |    2              4  4           3        3  4  2           3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +           +  +                       +              +            |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Congestion                           |                                                                          |             
      Hyperplasia, Macrophage              |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Lymphoid                |                         2                          4  3              4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  I  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                         2           2              3                    3|             
      Hyperplasia, Plasma Cell             |                                                       4                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |             2  1        1  2        2              3     2     1         |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                      +              +  +  +     +                       +|             
      Cyst Epithelial Inclusion            |                                     X                                    |             
      Hyperkeratosis                       |                      4                                                   |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Degeneration               |                                                                          |             
      Cerebrum, Necrosis                   |                                                                          |             
      Hypothalamus, Compression            | X                             X                 X                        |             
      Pons, Compression                    |                         X                                                |             
      Thalamus, Degeneration               |                                                                          |             
      Ventricle, Dilatation                |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 1| 7| 6| 7| 7| 5| 6|             
                             DAY ON TEST   | 2| 0| 6| 3| 3| 6| 2| 3| 3| 9| 9| 3| 3| 2| 8| 8| 6| 2| 8| 3| 2| 3| 1| 2| 9|             
                                           | 4| 5| 6| 6| 3| 9| 9| 3| 3| 6| 7| 7| 6| 8| 1| 4| 9| 2| 7| 3| 2| 6| 5| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                               1  1                                       |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1  1     1  1  1     2  1           1           1        1  1  1  2      |             
      Mineralization                       |                                                                   2      |             
      Alveolus, Pigmentation               |                         1                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                   1                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +                                   +  +                 +     +   |             
      Cataract                             |    3  1                                                        4         |             
      Anterior Chamber, Cornea,            |                                                                          |             
          Inflammation, Suppurative        |                                                                      4   |             
      Bilateral, Cornea, Edema             |                                           2                              |             
      Cornea, Edema                        |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                                   X      |             
      Nephropathy                          | 3  3  2  4  3     2  4  3  3  2  3  3  1  2     2  2     3  1  2  4  1  2|             
      Bilateral, Nephropathy               |                4                                                         |             
      Cortex, Cyst                         |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                      X   |             
      Inflammation, Subacute               |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|             
                                           | 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1     1     1  1     1              1                    1              1|             
      Clear Cell Focus                     |                                                             1            |             
      Degeneration, Cystic                 |             2                    1              1        3           2   |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |          4     1  2     1                    1  3  1                 2   |             
      Hepatodiaphragmatic Nodule           |                               X                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Bile                   |    1                                                                     |             
      Thrombosis                           |                                                                X         |             
      Thrombosis, Multiple                 |             X                    X                                       |             
      Bile Duct, Hyperplasia               |    2  2     3        2           2     2  3     2     2  2     2         |             
      Hepatocyte, Hyperplasia              |             2                          2                 2     2         |             
      Hepatocyte, Necrosis                 |             2        1  1        1  1  1                          1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2                        |             
      Acinus, Atrophy                      |             2                                                  1         |             
      Acinus, Fibrosis                     |             4                                                            |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          2                                                               |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |          3                                                               |             
      Ulcer, Multiple                      |                                     2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      1                          3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|             
                                           | 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                 X                    X   |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |    4  2  2  1  1                       2  4        2  4     1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                                  |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                                      +            |             
      Oral, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                     +                          +         |             
      Inflammation, Chronic                |                                     3                                    |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     4                                    |             
      Inflammation, Suppurative            |          2              1                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                 3                                         3   |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          4           3   |             
      Interstitial Cell, Hyperplasia       | 1           2     1  1                                      1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|             
                                           | 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |          2                       2  2           1        2               |             
      Hyperplasia                          |       4  4  3     4  4  3        3  3  3  4     3  4  4        4     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +           +           +  +              +        +         |             
      Iliac, Hyperplasia, Lymphoid         |                                     3                                    |             
      Pancreatic, Hyperplasia, Lymphoid    | 3                                                                        |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     2                                    |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         1                                                |             
      Ectasia                              |                                                          2               |             
      Hyperplasia, Lymphoid                |                                                                   1      |             
      Hyperplasia, Plasma Cell             |                                  2  2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                                        1                             2   |             
      Infarct                              |                                  4           2        2        1         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  I  +  +  +  +  I  I  M  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +                 +     +  +  +     +      |             
      Cyst Epithelial Inclusion            |                                                       X                  |             
      Hyperkeratosis                       |                                                                          |             
      Pigmentation                         |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Degeneration               |                                                 2                        |             
      Cerebrum, Necrosis                   |                                           4                              |             
      Hypothalamus, Compression            | X              X                    X                             X     X|             
      Pons, Compression                    |                                                                   X      |             
      Thalamus, Degeneration               |                                                                   1      |             
      Ventricle, Dilatation                | 2                                                                       3|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 5| 4| 5| 5| 7| 6| 6| 6| 7| 5| 6| 6| 7| 6| 7| 5| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 0| 7| 9| 1| 9| 7| 8| 0| 1| 2| 2| 8| 3| 9| 6| 2| 2| 5| 3| 6| 2| 0| 7| 7|             
                                           | 9| 3| 3| 2| 3| 4| 5| 5| 9| 3| 8| 2| 2| 6| 8| 1| 2| 4| 6| 7| 6| 4| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/M3                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1        1              1  1     1  1  1           2  1  1  1        1|             
      Mineralization                       |                                                                          |             
      Alveolus, Pigmentation               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                  1              1              1        1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                 +                              |             
      Cataract                             |                                                                          |             
      Anterior Chamber, Cornea,            |                                                                          |             
          Inflammation, Suppurative        |                                                                          |             
      Bilateral, Cornea, Edema             |                                                                          |             
      Cornea, Edema                        |                         1                                                |             
      Sclera, Metaplasia, Osseous          |                                           1                              |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 3        3  3  3     2  1  3     1  4  2  1  2  2  3  1  2  2  2  3  4  2|             
      Bilateral, Nephropathy               |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                             X            |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 6| 7| 3| 6|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |      A     |
    0 MG/M3                                | 6| 6| 6| 6|                                                              |      L     |
                                           | 0| 1| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  54        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  54        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  54        |
      Basophilic Focus                     | 2  1  1                                                                  |     21  1.2|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Degeneration, Cystic                 |          2                                                               |     16  1.8|
      Eosinophilic Focus                   |    1  1                                                                  |      3  1.0|
      Fatty Change                         |                                                                          |     13  1.8|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Pigmentation, Bile                   |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1     |
      Thrombosis, Multiple                 |                                                                          |      2     |
      Bile Duct, Hyperplasia               |          2                                                               |     17  2.1|
      Hepatocyte, Hyperplasia              | 2        2                                                               |      8  1.9|
      Hepatocyte, Necrosis                 |                                                                          |      8  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  54        |
      Atrophy                              |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      5  1.4|
      Acinus, Fibrosis                     |                                                                          |      1  4.0|
      Acinus, Hyperplasia                  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  54        |
      Edema                                |          3                                                               |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Ulcer, Multiple                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  54        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 6| 7| 3| 6|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |      A     |
    0 MG/M3                                | 6| 6| 6| 6|                                                              |      L     |
                                           | 0| 1| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Aorta, Mineralization                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  54        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Atrium, Thrombosis                   | X                                                                        |      4     |
      Myocardium, Mineralization           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +                                                               |  54        |
      Degeneration, Fatty                  |       3                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +                                                               |  54        |
      Degeneration, Fatty                  |                                                                          |      1  4.0|
      Hyperplasia                          | 3  1                                                                     |     25  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  54        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +                                                               |  50        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  53        |
      Angiectasis                          | 2                                                                        |      2  2.0|
      Pars Distalis, Cyst                  | X                                                                        |      2     |
      Pars Distalis, Hyperplasia           | 4                                                                        |      4  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  54        |
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
      Oral, Inflammation, Chronic Active   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +                                                               |  54        |
      Spermatocele                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +                                                               |  54        |
      Ectasia                              |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +                                                               |  53        |
      Inflammation, Chronic                |                                                                          |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 6| 7| 3| 6|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |      A     |
    0 MG/M3                                | 6| 6| 6| 6|                                                              |      L     |
                                           | 0| 1| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +                                                               |  54        |
      Atrophy                              |                                                                          |      3  2.3|
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +                                                               |  54        |
      Atrophy                              |          4                                                               |     11  3.4|
      Interstitial Cell, Hyperplasia       |                                                                          |      7  1.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  54        |
      Fibrosis                             |                                                                          |      7  1.7|
      Hyperplasia                          |          3                                                               |     24  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |  16        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +                                                               |  52        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M                                                               |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +                                                               |  47        |
      Congestion                           |                                                                          |      1  1.0|
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.2|
      Hyperplasia, Plasma Cell             |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  54        |
      Developmental Malformation           | X                                                                        |      1     |
      Fibrosis                             |          3                                                               |     11  1.8|
      Infarct                              |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +                                                               |  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +                                                               |  54        |
      Hyperplasia                          |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                                                                  |  13        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 6| 7| 3| 6|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |      A     |
    0 MG/M3                                | 6| 6| 6| 6|                                                              |      L     |
                                           | 0| 1| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  54        |
      Cerebrum, Degeneration               |                                                                          |      1  2.0|
      Cerebrum, Necrosis                   |                                                                          |      1  4.0|
      Hypothalamus, Compression            |                                                                          |      8     |
      Pons, Compression                    |                                                                          |      2     |
      Thalamus, Degeneration               |                                                                          |      1  1.0|
      Ventricle, Dilatation                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +                                                               |  52        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Inflammation, Suppurative            | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  54        |
      Inflammation, Chronic                | 1  1     1                                                               |     28  1.1|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolus, Pigmentation               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  54        |
      Inflammation, Chronic Active         |    1                                                                     |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  53        |
      Inflammation, Focal, Suppurative     |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   9        |
      Cataract                             |          4                                                               |      4  3.0|
      Anterior Chamber, Cornea,            |                                                                          |            |
          Inflammation, Suppurative        |                                                                          |      1  4.0|
      Bilateral, Cornea, Edema             |                                                                          |      1  2.0|
      Cornea, Edema                        |                                                                          |      1  1.0|
      Sclera, Metaplasia, Osseous          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7|                                                              |            |
                             DAY ON TEST   | 3| 3| 3| 3|                                                              |            |
                                           | 6| 7| 3| 6|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |      A     |
    0 MG/M3                                | 6| 6| 6| 6|                                                              |      L     |
                                           | 0| 1| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  54        |
      Cyst                                 |                                                                          |      2     |
      Nephropathy                          | 4  3  4  4                                                               |     47  2.5|
      Bilateral, Nephropathy               |                                                                          |      1  4.0|
      Cortex, Cyst                         |       X                                                                  |      2     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  54        |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Inflammation, Subacute               |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|             
                                           | 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                              1        1        3        1|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |          2                                   1  3     1              3   |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   | 1     2                                   X                              |             
      Fatty Change                         |                   2                    1     2     2        3            |             
      Hepatodiaphragmatic Nodule           |                                                                         X|             
      Thrombosis                           |    X                                                                     |             
      Bile Duct, Hyperplasia               | 2  3  2  3     2     2                    3     4  3                     |             
      Hepatocyte, Hyperplasia              | 2  2  2  3     2              2     2     2  1  4     2              2   |             
      Hepatocyte, Necrosis                 | 2  3                    1           1     1     3  2           1     2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                             4            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |    2                                                                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                 1                        |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Atrium, Thrombosis                   |    X                 X                          X                        |             
      Epicardium, Degeneration             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|             
                                           | 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Degeneration, Fatty                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 2  4     1           2  4     3     1  1  1  4  3  2     2  2  2  1     1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     3           1                                                      |             
      Hyperplasia                          |    1                                                                     |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |                         4                                                |             
      Pars Distalis, Necrosis              |             3                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       2                                                                  |             
      Inflammation, Suppurative            |                                                       4                  |             
      Bilateral, Ectasia                   |                                                 4                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                  1     2                                 |             
      Inflammation, Chronic Active         |                            1                                             |             
      Inflammation, Suppurative            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4     3              2                                      4   |             
      Bilateral, Atrophy                   |                                                                          |             
      Interstitial Cell, Hyperplasia       |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   2  1                                                   |             
      Hyperplasia                          | 4  2  4  2  2  3  3  2  4  2  3     3     2     2  2  3  3        3  3  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|             
                                           | 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +        +  +           +              +  +  +           +      |             
      Pigmentation                         |                   1              1                 1                     |             
      Iliac, Congestion                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Pancreatic, Congestion               |                                                                          |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Pigmentation                  |                      1                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                           2                              |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
      Pigmentation                         | 1  1  1  1  1  1  1     1     2  1  2  1  1  1  2  1  1        1  2  1  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                      2   |             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Hyperplasia, Plasma Cell             |             3                                                            |             
      Pigmentation                         |    1  1     1     1  1     1     1  2     2        2  2     1     1  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            2                                   2         |             
      Infarct                              | 4                                                        4               |             
      Necrosis                             |                                                          3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                         +     +                                          |             
      Cyst Epithelial Inclusion            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                          2               |             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 6| 6| 6| 7| 4| 5| 5| 6| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 9| 8| 3| 6| 8| 4| 4| 0| 6| 7| 9| 7| 1| 2| 3| 2| 1| 3| 3| 6| 0| 0| 3| 3|             
                                           | 9| 7| 6| 3| 4| 5| 7| 3| 3| 6| 0| 5| 5| 9| 3| 3| 0| 8| 6| 3| 7| 4| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 2| 3| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cerebellum, Compression              |                                        X                                 |             
      Cerebellum, Hemorrhage               |                                                          1        3      |             
      Cerebrum, Compression                |                               X        X                                 |             
      Cerebrum, Hemorrhage                 |                                                          1               |             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                | 1  2  1  1  1  1  2  1  2  2  2  1  2  1  1  2  2  2  1  2  1  2  1  2  1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |       3                                                                  |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |          1                                                               |             
      Alveolus, Pigmentation               | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  2  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1                                                      |             
      Inflammation, Suppurative            |    2                             1                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                         +         |             
      Cataract                             |                                                                1         |             
      Cornea, Inflammation, Suppurative    |                                                                2         |             
      Lids, Inflammation, Chronic Active   |                                                                3         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |    2                                                                     |             
      Nephropathy                          | 2  2  1  4  2  3  2  2  2     1  1  3  2  2  4  4  2  4  2  4  3     3  3|             
      Pigmentation                         |             1                                                            |             
      Bilateral, Cortex, Cyst              |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|             
                                           | 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    1           1        1     3              2           2  3     3     1|             
      Clear Cell Focus                     |                                                                   1      |             
      Degeneration, Cystic                 |       3  1  2     1     2     2  2  4  2     1  3  1        1  4         |             
      Developmental Malformation           |                                                             X            |             
      Eosinophilic Focus                   |                                                          1               |             
      Fatty Change                         | 1     2  2  3  1  2  1                             1        1            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |       2  4  2     2  3        2  2              2              2     3   |             
      Hepatocyte, Hyperplasia              |                                                       3                  |             
      Hepatocyte, Necrosis                 |       1  2                    1                       2              2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3                                    |             
      Acinus, Atrophy                      |                                                                   1      |             
      Acinus, Hyperplasia                  |          1                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                             2            |             
      Inflammation, Chronic                |                                                             3            |             
      Ulcer                                |             3  3                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          1                                                               |             
      Atrium, Thrombosis                   |       X     X                    X                                       |             
      Epicardium, Degeneration             |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|             
                                           | 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Degeneration, Fatty                  |                                                             1            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
      Hyperplasia                          |    1     2     1                 1  2  2                          4     1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     3                    1              1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Pars Distalis, Angiectasis           |                                        3                                 |             
      Pars Distalis, Hyperplasia           |                                        3                                2|             
      Pars Distalis, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                       +                                             |             
      Developmental Malformation           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          2                                                              1|             
      Inflammation, Suppurative            |                                                                          |             
      Bilateral, Ectasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          1                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        4                    4            |             
      Bilateral, Atrophy                   |                                                                3         |             
      Interstitial Cell, Hyperplasia       |                      1                          2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   3                             1                        |             
      Hyperplasia                          | 3  2  3  3  2     2  4           1  3  2        4     3        2     3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|             
                                           | 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +     +  +           +  +                 +              +   |             
      Pigmentation                         |                                                                      1   |             
      Iliac, Congestion                    |             1                                                            |             
      Iliac, Hyperplasia, Lymphoid         |             1                                                            |             
      Pancreatic, Congestion               |             1                                                            |             
      Renal, Congestion                    |             1                                                            |             
      Renal, Hyperplasia, Lymphoid         | 2           1                                                            |             
      Renal, Pigmentation                  | 2                                   2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             1                                                            |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |          2                                2  2                 1  1     2|             
      Pigmentation                         |    1  1  2  1     1  1  2     1  1  2  2  1  2     2  1  2  2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                        3  2        2           4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             1           2                                                |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2                             2                              |             
      Hyperplasia, Lymphoid                | 3              1        2              2                       2        2|             
      Hyperplasia, Plasma Cell             |          2                                                               |             
      Pigmentation                         | 2     2  1  1  1        2     2  2     2  2  2  1     2  1  2  2  2     2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2              3                    2  2         |             
      Infarct                              |          4  4        2                          4                        |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                     2                                    |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +        +                                             |             
      Cyst Epithelial Inclusion            |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Femur, Hyperostosis                  |                                                          1     1         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 7| 6| 7| 5| 7| 6| 6| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 7| 1| 0| 2| 1| 1| 3| 7| 3| 4| 9| 3| 4| 3| 7| 9| 3| 3| 3| 3| 3| 7| 3|             
                                           | 0| 4| 9| 7| 0| 9| 7| 8| 3| 2| 6| 9| 6| 3| 2| 6| 0| 7| 8| 6| 3| 7| 3| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.62MGM3                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cerebellum, Compression              |                                                                          |             
      Cerebellum, Hemorrhage               |                                                                          |             
      Cerebrum, Compression                |          X     X                                   X                     |             
      Cerebrum, Hemorrhage                 |                                                                          |             
      Ventricle, Dilatation                |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             1                                                            |             
      Inflammation, Chronic                | 1  1  1  2  2  2  2  1  2  2  1  2  2  2  1  2  2  2  2  2  2  2  2  2  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                              1                           |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |                                                                          |             
      Alveolus, Pigmentation               | 1  1  1  1  1  1  1  1  2  1  2  1  2  2  1  2  1  2  1  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                                   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +        +              +                                    |             
      Cataract                             |             2                       2                                    |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Lids, Inflammation, Chronic Active   |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                                                      |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 1     3  3  2  4  3  3  3  2  3  2  3  4  2  4  2  4  1  2  4  2  3  4  3|             
      Pigmentation                         |                                                                          |             
      Bilateral, Cortex, Cyst              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 7| 3|                                                                 |            |
                                           | 2| 9| 3|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    0.62MGM3                               | 9| 9| 9|                                                                 |      L     |
                                           | 2| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Basophilic Focus                     | 2     1                                                                  |     15  1.7|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Degeneration, Cystic                 | 1                                                                        |     20  2.0|
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      4  1.3|
      Fatty Change                         |    2                                                                     |     15  1.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Hyperplasia               |    2                                                                     |     20  2.5|
      Hepatocyte, Hyperplasia              |    2                                                                     |     14  2.2|
      Hepatocyte, Necrosis                 |                                                                          |     14  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 7| 3|                                                                 |            |
                                           | 2| 9| 3|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    0.62MGM3                               | 9| 9| 9|                                                                 |      L     |
                                           | 2| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      6     |
      Epicardium, Degeneration             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      2  2.0|
      Degeneration, Fatty                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          | 3     3                                                                  |     27  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      3  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                                                                          |      3  3.0|
      Pars Distalis, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      3  1.7|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Bilateral, Ectasia                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 7| 3|                                                                 |            |
                                           | 2| 9| 3|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    0.62MGM3                               | 9| 9| 9|                                                                 |      L     |
                                           | 2| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +                                                                  |  53        |
      Atrophy                              |       3                                                                  |      7  3.4|
      Bilateral, Atrophy                   |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      4  1.8|
      Hyperplasia                          |    4                                                                     |     35  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +                                                                     |  19        |
      Pigmentation                         |                                                                          |      4  1.0|
      Iliac, Congestion                    | 2                                                                        |      2  1.5|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  1.0|
      Pancreatic, Congestion               |                                                                          |      1  1.0|
      Renal, Congestion                    |    2                                                                     |      2  1.5|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  1.5|
      Renal, Pigmentation                  |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  51        |
      Congestion                           |                                                                          |      1  1.0|
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      7  1.7|
      Pigmentation                         | 2  2  1                                                                  |     45  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      2  1.5|
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  52        |
      Congestion                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                | 2                                                                        |      8  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
      Pigmentation                         | 2                                                                        |     33  1.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Fibrosis                             |    2                                                                     |      7  2.1|
      Infarct                              |                                                                          |      6  3.7|
      Necrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 7| 3|                                                                 |            |
                                           | 2| 9| 3|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    0.62MGM3                               | 9| 9| 9|                                                                 |      L     |
                                           | 2| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   4        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Hyperostosis                         |                                                                          |      1  2.0|
      Femur, Hyperostosis                  |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Cerebellum, Compression              |                                                                          |      1     |
      Cerebellum, Hemorrhage               |                                                                          |      2  2.0|
      Cerebrum, Compression                |                                                                          |      5     |
      Cerebrum, Hemorrhage                 |                                                                          |      1  1.0|
      Ventricle, Dilatation                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic                | 2  2  2                                                                  |     53  1.6|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  2.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
      Alveolus, Pigmentation               | 1  2  2                                                                  |     53  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Cataract                             |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 1| 7| 3|                                                                 |            |
                                           | 2| 9| 3|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    0.62MGM3                               | 9| 9| 9|                                                                 |      L     |
                                           | 2| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cornea, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Lids, Inflammation, Chronic Active   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1     |
      Infarct                              |                                                                          |      1  2.0|
      Nephropathy                          | 3  3  4                                                                  |     50  2.7|
      Pigmentation                         |                                                                          |      1  1.0|
      Bilateral, Cortex, Cyst              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|             
                                           | 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         4                                                |             
      Necrosis                             |                         4                                                |             
      Parasite Metazoan                    |                                                                          |             
      Ulcer                                |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Basophilic Focus                     |    1     1     1     1              1  2  1  1              1     2      |             
      Congestion                           |                                                       3                  |             
      Degeneration, Cystic                 | 1  1     2  2  1        3  3              3        2  2  2     1  2  1   |             
      Eosinophilic Focus                   |          1     1     1                                X                  |             
      Fatty Change                         | 1     2     2     2     2        2           2  2  2     2     1         |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Pigmentation, Bile                   |                                                          2               |             
      Thrombosis                           |                               X                                          |             
      Bile Duct, Hyperplasia               |             2           2  2           3  2        2  3  3     2     2   |             
      Hepatocyte, Hyperplasia              |    1                          2        3        2     2                  |             
      Hepatocyte, Necrosis                 |                                                                1         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |       2                             2        3  2                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                              3  2                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                     2        4                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|             
                                           | 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +                                                               |             
      Aorta, Mineralization                |          1                                                               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Atrium, Thrombosis                   |             X                                                  X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                         2                 2                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        4        2  4  3  4  1  1  2     4  1  4  1  3        4      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                 3                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                2              3                                          |             
      Pars Distalis, Pigmentation          |                                                       1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                      3                                                   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      C-Cell, Hyperplasia                  |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               3                          3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                   3                    4                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                                                  3                  |             
      Ectasia                              |                                                                   2      |             
      Inflammation, Suppurative            |                                        4     3                           |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3              4                                                  3      |             
      Hemorrhage                           |                                                                          |             
      Bilateral, Atrophy                   |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|             
                                           | 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       1                                   2              2     1     1   |             
      Hyperplasia                          |       1                 4  4  4  2        2     2     4        2     3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +  +        +                 +  +     +     +     +   |             
      Iliac, Ectasia                       |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Pigmentation                  |                                                    1                     |             
      Renal, Congestion                    |                                                                2         |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                1                       2                          2      |             
      Pigmentation                         | 2  2  2  2  2  2  1  2  1  2  1  1  2  2  2  2  1  2  2     2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2  2     3     2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                | 2              2                             2              2     2     3|             
      Pigmentation                         | 2  2  2     2  2     2  2     1  1  2  2  2  2  1  2  2  1  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                                    X                     |             
      Fibrosis                             | 1  2     2  2              2        2     2                 2     2      |             
      Infarct                              |                               3                                          |             
      Necrosis                             |                                                                          |             
      Capsule, Fibrosis                    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |             +              +  +           +           +                 +|             
      Alopecia                             |                                                       2                  |             
      Cyst Epithelial Inclusion            |                                                       X                  |             
      Hyperkeratosis                       |                                                                          |             
      Necrosis                             |                               3                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |             2                                                  1         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 2| 7| 6| 6| 7| 6| 6| 7| 7| 6| 5| 5| 5| 6| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 3| 0| 3| 1| 9| 0| 2| 0| 3| 1| 7| 9| 8| 6| 5| 3| 9| 3| 0| 2|             
                                           | 3| 6| 9| 0| 6| 6| 2| 3| 8| 0| 6| 7| 6| 3| 7| 4| 2| 8| 4| 0| 3| 7| 3| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25MGM3                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cerebellum, Compression              |                                                                          |             
      Cerebellum, Hemorrhage               |                                                                          |             
      Cerebellum, Ventricle, Dilatation    |                                                                          |             
      Cerebrum, Compression                |                                  X                                       |             
      Cerebrum, Hemorrhage                 |                                                                          |             
      Cerebrum, Ventricle, Dilatation      |                                  1                                       |             
      Hypothalamus, Compression            |                                                                          |             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                1         |             
      Inflammation, Chronic                | 2  2  2  2  2  3  2  2  2  2  2  2  2  3  2  3  2  2  2  2  2  2  2  2  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                                                                   2      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Pigmentation               | 2  2  2  2  2  2  1  2  2  2  2  2  2  3  2  2  2  1  1  1  2  1  2  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         1|             
      Inflammation, Suppurative            |       3                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                 +                     |             
      Cataract                             |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X     X                                                               |             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 3  4  2  4  2  2     1  3  3     3  2  4  4  3  2  2  2  3  2  2  3  4  1|             
      Medulla, Cyst                        |                                                                          |             
      Pelvis, Degeneration                 |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                   X                 X                                    |             
      Metaplasia, Squamous                 |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|             
                                           | 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Parasite Metazoan                    |    X                                                                     |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    2  4     2        1     1     3  2     2           1  2        1  1   |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |       1  1  2     1  1  1        1  1     1  1        1  1               |             
      Eosinophilic Focus                   | X                                                                        |             
      Fatty Change                         | 2        2     2                       2        3           2        1  3|             
      Hepatodiaphragmatic Nodule           |             X                                         X                  |             
      Inflammation, Chronic Active         |                                     1                                    |             
      Pigmentation, Bile                   |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2        2        2                 2  2     3                 2         |             
      Hepatocyte, Hyperplasia              | 2        2                                                     2        2|             
      Hepatocyte, Necrosis                 |          2                             1                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                     1                                    |             
      Acinus, Atrophy                      |          3                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                2                                2                        |             
      Inflammation, Acute                  | 2                                                                        |             
      Inflammation, Chronic                |                2                                                         |             
      Inflammation, Chronic Active         |                                                 2                        |             
      Ulcer                                | 1                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          2                                                               |             
      Inflammation, Suppurative            |                                                             3            |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|             
                                           | 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     1                                    |             
      Atrium, Thrombosis                   |          X                                                  X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |       2                          1                       1  2            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  4  4     1  4                 2  2           1     3        2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 3                                2        4                    2         |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                            1                                             |             
      C-Cell, Hyperplasia                  |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |          X                 X                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               4                                      2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                                                                  |             
      Inflammation, Chronic Active         |       4                                                                  |             
      Inflammation, Suppurative            | 3                                   2                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                                                        |             
      Ectasia                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4        3                          3                       3            |             
      Hemorrhage                           |                                        2                                 |             
      Bilateral, Atrophy                   |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|             
                                           | 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |       2           3  2              2  4     3                 3        1|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +                                   +              +  +        +|             
      Iliac, Ectasia                       |       4                                                                  |             
      Iliac, Hyperplasia, Lymphoid         |       3                                                                  |             
      Iliac, Pigmentation                  |                                                                          |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |          4                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    1        2        2        2     3     2                       1      |             
      Pigmentation                         | 2  2  1  2  2  2  1  2  1  2  2  2  2  2  2     2  2  2  2  2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      2     3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Ectasia                              |                                           4                              |             
      Hyperplasia, Lymphoid                |             2              2                       2  2           2      |             
      Pigmentation                         | 2  1  2  2  2     2     1  2  2     2     1     2  2  2     2  2  2     1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3                                                               |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             | 3     2              1                       2        1              2   |             
      Infarct                              |                                        2                                2|             
      Necrosis                             |          2                                                               |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +           +        +     +     +        +        +              +      |             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |                                           X                              |             
      Hyperkeratosis                       |                      2                                                   |             
      Necrosis                             |                                                                          |             
      Epidermis, Hyperplasia               | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6| 3| 5| 7| 7| 6| 5| 5| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 6| 4| 9| 2| 0| 2| 3| 3| 7| 3| 8| 6| 7| 3| 3| 7| 6| 4| 4| 4|             
                                           | 4| 8| 3| 9| 3| 7| 7| 0| 4| 7| 0| 6| 6| 0| 7| 1| 7| 8| 7| 3| 6| 7| 1| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25MGM3                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cerebellum, Compression              |                               X                                          |             
      Cerebellum, Hemorrhage               |                   1           2                                1         |             
      Cerebellum, Ventricle, Dilatation    |                                                 2                        |             
      Cerebrum, Compression                |                X        X  X  X                 X                        |             
      Cerebrum, Hemorrhage                 |                               2                                          |             
      Cerebrum, Ventricle, Dilatation      |                         2                                                |             
      Hypothalamus, Compression            |                                                          X               |             
      Ventricle, Dilatation                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                | 2  2  2  2  2  2  2  2  2  2  2  2  2  1  3  2  2  2  3  2  2  2  3  3  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                                     2              2  1                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                           2                              |             
      Alveolus, Pigmentation               | 2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1                                                                     |             
      Inflammation, Suppurative            |                   1  2                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Necrosis                             |                               1                                          |             
      Nephropathy                          | 4  3  4  3  2  3  3  1  2  4  1  4  3  2  2  3     1  3  3  3  1  1  2  1|             
      Medulla, Cyst                        |                                                       X                  |             
      Pelvis, Degeneration                 |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                          X               |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6|                                                                 |            |
                             DAY ON TEST   | 1| 5| 8|                                                                 |            |
                                           | 9| 7| 1|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 2| 2| 2|                                                                 |      L     |
                                           | 3| 4| 5|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                          |      1     |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |     22  1.5|
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Cystic                 |       2                                                                  |     27  1.5|
      Eosinophilic Focus                   |                                                                          |      5  1.0|
      Fatty Change                         | 3                                                                        |     20  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Pigmentation, Bile                   |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Hyperplasia               |       2                                                                  |     18  2.2|
      Hepatocyte, Hyperplasia              |                                                                          |      9  2.0|
      Hepatocyte, Necrosis                 |    1                                                                     |      4  1.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperkeratosis                       |                                                                          |      6  2.2|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6|                                                                 |            |
                             DAY ON TEST   | 1| 5| 8|                                                                 |            |
                                           | 9| 7| 1|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 2| 2| 2|                                                                 |      L     |
                                           | 3| 4| 5|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Pigmentation                         |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      4     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Degeneration, Fatty                  |                                                                          |      6  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |     26  2.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +                                                                  |  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Pars Distalis, Hyperplasia           |                                                                          |      6  2.7|
      Pars Distalis, Pigmentation          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +                                                                  |  52        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +                                                                  |  53        |
      Spermatocele                         |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6|                                                                 |            |
                             DAY ON TEST   | 1| 5| 8|                                                                 |            |
                                           | 9| 7| 1|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 2| 2| 2|                                                                 |      L     |
                                           | 3| 4| 5|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      3  3.3|
      Ectasia                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      7  3.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Bilateral, Atrophy                   |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      5  1.4|
      Hyperplasia                          |       3                                                                  |     19  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                                                                  |  16        |
      Iliac, Ectasia                       |                                                                          |      1  4.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Iliac, Pigmentation                  |                                                                          |      1  1.0|
      Renal, Congestion                    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  53        |
      Hyperplasia, Lymphoid                |                                                                          |     10  1.8|
      Pigmentation                         | 1  1  1                                                                  |     51  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  52        |
      Ectasia                              |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |     11  2.1|
      Pigmentation                         | 1  1  1                                                                  |     43  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  3.0|
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis                             |                                                                          |     15  1.9|
      Infarct                              |                                                                          |      3  2.3|
      Necrosis                             |                                                                          |      1  2.0|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6|                                                                 |            |
                             DAY ON TEST   | 1| 5| 8|                                                                 |            |
                                           | 9| 7| 1|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 2| 2| 2|                                                                 |      L     |
                                           | 3| 4| 5|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  14        |
      Alopecia                             |                                                                          |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Hyperostosis                         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Cerebellum, Compression              |                                                                          |      1     |
      Cerebellum, Hemorrhage               |                                                                          |      3  1.3|
      Cerebellum, Ventricle, Dilatation    |                                                                          |      1  2.0|
      Cerebrum, Compression                |       X                                                                  |      7     |
      Cerebrum, Hemorrhage                 |                                                                          |      1  2.0|
      Cerebrum, Ventricle, Dilatation      |                                                                          |      2  1.5|
      Hypothalamus, Compression            |                                                                          |      1     |
      Ventricle, Dilatation                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  53        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic                | 2  2  3                                                                  |     53  2.1|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Atypical                        |                                                                          |      4  1.8|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolus, Pigmentation               | 2  1  2                                                                  |     53  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6|                                                                 |            |
                             DAY ON TEST   | 1| 5| 8|                                                                 |            |
                                           | 9| 7| 1|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    1.25MGM3                               | 2| 2| 2|                                                                 |      L     |
                                           | 3| 4| 5|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      2     |
      Necrosis                             |                                                                          |      1  1.0|
      Nephropathy                          |       4                                                                  |     48  2.6|
      Medulla, Cyst                        |                                                                          |      1     |
      Pelvis, Degeneration                 |       4                                                                  |      1  4.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      3     |
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|             
                                           | 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          2     2              2  2  1     1           1     1  1     1  2|             
      Congestion                           |                                                                         2|             
      Degeneration, Cystic                 | 1  2           1  2     1        1  1     1        2     1  2     2     1|             
      Developmental Malformation           |                                                             X            |             
      Eosinophilic Focus                   |    X                             1                    1                  |             
      Fatty Change                         |                      2                       2  2              2        1|             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           | X                                                     X                  |             
      Infarct                              |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2  3           2  2  2                    2  2  2  3     2        2      |             
      Hepatocyte, Hyperplasia              | 4        2     2  2     2                       1                        |             
      Hepatocyte, Necrosis                 |                      1                          1  3              1      |             
      Portal Vein, Thrombosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         1|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |    2                                                                     |             
      Atrium, Congestion                   |                                                                          |             
      Atrium, Thrombosis                   |                      X                       X                           |             
      Ventricle, Fibrosis                  |                                                                          |             
      Ventricle, Inflammation, Chronic     |                                                                          |             
      Ventricle, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|             
                                           | 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                         2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2              2  2  3                 2  4  3           4     1  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   3                 1        1                           |             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hyperplasia           |          4                       1                             2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                  +  +                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Glandular               |                                                                          |             
      Inflammation, Suppurative            |          1                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4        4     3                    4                    2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          | 2  3     3  2     2  2     3        3     3  3  3  2     2     3  3  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +        +              +                     |             
      Hyperplasia, Macrophage              |                                                                          |             
      Iliac, Pigmentation                  |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|             
                                           | 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Edema                         |                                                                          |             
      Renal, Pigmentation                  |                                     1              2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       1                                                                  |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |       2  2  2           1        2  2     2  1           1           2  1|             
      Pigmentation                         | 2  2  2  2  2  2  2  1  2  2  2  2  1     2  2  2  2  1  2  2  2  1  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                       2                                   2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |    2     2  3        1              2     3        2     2        3  2  1|             
      Hyperplasia, Plasma Cell             |                                                 3                        |             
      Pigmentation                         |    2  1  2  2  2  1  1  1  2  2  2  2     1  2  2  2  1  1  2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2     1     2     2                                         1            |             
      Infarct                              |                                              2     4                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +                             +                           |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                    1     1               |             
      Femur, Hyperostosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    1                     |             
      Cerebellum, Compression              |             X                                                            |             
      Cerebrum, Compression                |       X                 X                       X                       X|             
      Cerebrum, Necrosis                   |                                                                          |             
      Cerebrum, Ventricle, Dilatation      |                         2                                               2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 4| 0| 5| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 9| 7| 2| 3| 6| 3| 3| 3| 0| 3| 3| 3| 6| 2| 9| 5| 7| 6| 6| 7| 3| 7| 6| 7| 2|             
                                           | 7| 9| 5| 6| 0| 7| 6| 6| 7| 9| 6| 6| 7| 8| 5| 3| 1| 5| 8| 1| 3| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                         1|             
      Inflammation, Chronic Active         |                      1                                                   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                   X                                                      |             
      Hemorrhage                           |                            2                                             |             
      Inflammation, Chronic                | 3  3  3  3  2  2  2  2  3  2  2  3  2     3  3  3  2  3  3  3  3  3  2  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                         3                                                |             
      Alveolus, Pigmentation               | 2  2  2  2  2  2  2  2  2  2  2  3  2     2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1                                                      |             
      Inflammation, Suppurative            |                      2                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +  +     +                                    |             
      Cataract                             |                               2     2                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Infarct                              |                                                    3                     |             
      Nephropathy                          | 4  2  2  3  2  3  2     3     2  3  1     3  1  2  3     2  3  2  3  1  3|             
      Cortex, Cyst                         |                X                                                         |             
      Medulla, Congestion                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|             
                                           | 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          3     1  3           3  1     2  1                          2   |             
      Congestion                           |                                              2                       2   |             
      Degeneration, Cystic                 | 2  3  1  2  1  2  1  2  1  4     1  1                    2     1  1      |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   | 1                                                     X              1   |             
      Fatty Change                         |       1                    1                 2        2        1        2|             
      Hemorrhage                           |                                                                      1   |             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Infarct                              |                      4                                                   |             
      Mixed Cell Focus                     |                               X                                          |             
      Thrombosis                           |       X                                                                  |             
      Bile Duct, Hyperplasia               |       3  2  2  2        2  2     2  2     2        2  2  2  2            |             
      Hepatocyte, Hyperplasia              | 2                                1           1                    2      |             
      Hepatocyte, Necrosis                 | 1     1        2           2                             2               |             
      Portal Vein, Thrombosis              |                                                          X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Acinus, Atrophy                      |    1                                            2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                            1                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                    2                     |             
      Inflammation, Chronic                |                                                                          |             
      Atrium, Congestion                   |                4                                                         |             
      Atrium, Thrombosis                   |       X                    X                                             |             
      Ventricle, Fibrosis                  |       2                                                                  |             
      Ventricle, Inflammation, Chronic     |       2                                                                  |             
      Ventricle, Mineralization            |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|             
                                           | 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Ventricle, Thrombosis                |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                        1                    1            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       4     2  3  4           2  1        2  4     2  3  2     1     1  4|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                             1                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                   X      |             
      Pars Distalis, Hyperplasia           |                   4  1     3                       2  2  3  1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                          +               |             
      Inflammation, Suppurative            |                                                          4               |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                  3                                       |             
      Hyperplasia, Glandular               |                                  4                                       |             
      Inflammation, Suppurative            |                3                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                    1                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4                 4  4  2                                            4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            2        2  2                 2               |             
      Hyperplasia                          | 2  3  2     3        3  3  2     3  3  2     3     2  2  3  4     3     3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +                       +  +  +  +     +        +     +     +|             
      Hyperplasia, Macrophage              |    4                                                                     |             
      Iliac, Pigmentation                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|             
                                           | 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Edema                         |                                        2                                 |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                4                                                         |             
      Edema                                |                                        2                                 |             
      Hyperplasia, Lymphoid                |          1        3              1              2     1        1         |             
      Pigmentation                         | 2  2  2  2  2  2  2  2  2  2  2  2  1     2  1  1  2  2  2  1  2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      1                       2                           |             
      Hyperplasia, Lymphoid                |          2        2        1  1  2  2                          2         |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         | 1  2  2  2  1  1  2  2  1  3  2  2  2  1  2  2  1  2  1  2  2  2  1  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2                 1              2           2   |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Congestion                           |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          2                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    |                         +                    +  +                    +   |             
      Cyst Epithelial Inclusion            |                                              X                           |             
      Pigmentation                         |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Femur, Hyperostosis                  |                   1                    2           2     3               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Cerebellum, Compression              |                                                                          |             
      Cerebrum, Compression                |          X                                                               |             
      Cerebrum, Necrosis                   |       1                                                                  |             
      Cerebrum, Ventricle, Dilatation      |          2                                                               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 6| 5| 5| 5| 5| 6| 6| 5| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 7| 0| 6| 1| 3| 0| 2| 2| 5| 3| 7| 3| 1| 8| 9| 7| 4| 1| 2| 4| 3| 3| 6|             
                                           | 6| 6| 6| 7| 5| 7| 3| 9| 3| 3| 1| 6| 0| 3| 5| 3| 4| 8| 5| 5| 4| 4| 6| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2.5MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                3                                                         |             
      Inflammation, Chronic                | 2  3  2  2  3  3  2  3  3  3  3  2  3  3  3  2  2  3  3  2  3  2  3  2  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Atypical                        |                      2                                         1         |             
      Alveolus, Pigmentation               | 2  3  1  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  3  3  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          1  2                                1                           |             
      Inflammation, Suppurative            | 3                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +  +                  |             
      Cataract                             |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Fibrosis                             |                                                    2                     |             
      Infarct                              |       2                                                                  |             
      Nephropathy                          | 4  3  3  4  3  4  4  4  2  2  2  3  1  4  2  1     2     2        3  2   |             
      Cortex, Cyst                         |                                                                          |             
      Medulla, Congestion                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2.5MG/M3                               | 5| 5| 5|                                                                 |      L     |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  52        |
      Basophilic Focus                     |       1                                                                  |     20  1.7|
      Congestion                           |    4                                                                     |      4  2.5|
      Degeneration, Cystic                 |                                                                          |     28  1.5|
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |       X                                                                  |      7  1.0|
      Fatty Change                         |                                                                          |     11  1.6|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      4     |
      Infarct                              |                                                                          |      1  4.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Thrombosis                           |                                                                          |      1     |
      Bile Duct, Hyperplasia               |       2                                                                  |     25  2.1|
      Hepatocyte, Hyperplasia              |                                                                          |     10  1.9|
      Hepatocyte, Necrosis                 |    3                                                                     |     10  1.7|
      Portal Vein, Thrombosis              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Congestion                           |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  52        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2.5MG/M3                               | 5| 5| 5|                                                                 |      L     |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium, Congestion                   |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      4     |
      Ventricle, Fibrosis                  |                                                                          |      1  2.0|
      Ventricle, Inflammation, Chronic     |                                                                          |      1  2.0|
      Ventricle, Mineralization            |                                                                          |      1  1.0|
      Ventricle, Thrombosis                |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  52        |
      Degeneration, Fatty                  |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Hyperplasia                          |                                                                          |     24  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +                                                                  |  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Pars Distalis, Angiectasis           |                                                                          |      3  1.7|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |       1                                                                  |     11  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Hyperplasia                  |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +                                                                  |  52        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +                                                                  |  51        |
      Ectasia                              |                                                                          |      1  3.0|
      Hyperplasia, Glandular               |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +                                                                  |  52        |
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +                                                                  |  52        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2.5MG/M3                               | 5| 5| 5|                                                                 |      L     |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +                                                                  |  52        |
      Atrophy                              |                                                                          |     10  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  52        |
      Fibrosis                             |                                                                          |      4  2.0|
      Hyperplasia                          |    3  2                                                                  |     35  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  15        |
      Hyperplasia, Macrophage              |                                                                          |      1  4.0|
      Iliac, Pigmentation                  |                                                                          |      1  1.0|
      Renal, Edema                         |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +                                                                  |  52        |
      Congestion                           |    2                                                                     |      3  2.3|
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 2                                                                        |     18  1.6|
      Pigmentation                         | 2  1  2                                                                  |     51  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +                                                                  |  52        |
      Congestion                           |    2                                                                     |      3  1.7|
      Hyperplasia, Lymphoid                |                                                                          |     18  1.9|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Pigmentation                         | 1  2  2                                                                  |     50  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Fibrosis                             |       2                                                                  |     10  1.7|
      Infarct                              |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +                                                                  |  48        |
      Congestion                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  52        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   6        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Pigmentation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2.5MG/M3                               | 5| 5| 5|                                                                 |      L     |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  52        |
      Hyperostosis                         |                                                                          |      2  1.0|
      Femur, Hyperostosis                  |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Cerebellum, Compression              |                                                                          |      1     |
      Cerebrum, Compression                |                                                                          |      5     |
      Cerebrum, Necrosis                   |                                                                          |      1  1.0|
      Cerebrum, Ventricle, Dilatation      |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +                                                                  |  51        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Congestion                           |    3                                                                     |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Chronic                | 3  3  3                                                                  |     53  2.6|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Atypical                        |                                                                          |      3  2.0|
      Alveolus, Pigmentation               | 2  2  2                                                                  |     52  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |       1                                                                  |      5  1.2|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Cataract                             |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  52        |
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05123-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NICKEL OXIDE                                       Date: 08/23/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:44:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7|                                                                 |            |
                             DAY ON TEST   | 7| 4| 1|                                                                 |            |
                                           | 5| 7| 9|                                                                 |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0|                                                                 |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2.5MG/M3                               | 5| 5| 5|                                                                 |      L     |
                                           | 1| 3| 4|                                                                 |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      2  2.5|
      Nephropathy                          |    2  3                                                                  |     43  2.6|
      Cortex, Cyst                         |                                                                          |      1     |
      Medulla, Congestion                  |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.