National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1375

TDMS Study 05123-05 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: LITRI                                                    NICKEL OXIDE                                     DATE: 05/20/95       
EXPERIMENT: 05123 TEST: 05                                                                                     TIME: 04:51:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: Y01-ES-30108                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C00862       
PATHOLOGIST: P. HALEY                                                                                          CAS: 001313991       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: LITRI                                                    NICKEL OXIDE                                     DATE: 05/20/95      
EXPERIMENT: 05123 TEST: 05                                                                                     TIME: 04:51:15      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: Y01-ES-30108                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C00862      
PATHOLOGIST: P. HALEY                                                                                          CAS: 001313991      

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 40     CENSORED DEATHS 5    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      187   475   503   509   524   566   566   569   573   573                 |
 |      581   584   585   594   598   622   622   622   622   624                 |
 |      624   628   628   629   656   661   669   678   682   692                 |
 |      696   697   699   699   705   705   713   713   715   724                 |
 |  CENSORED DEATHS                                                               |
 |      459   459   459   459   459                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 MG/M3 LUNGTX                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 6      UNCENSORED DEATHS 0      CENSORED DEATHS 6    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   199                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.62MGM3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 38     CENSORED DEATHS 5    TERMINAL 15        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      466   503   519   520   524   538   542   564   567   570                 |
 |      570   572   595   618   618   623   629   633   643   647                 |
 |      649   670   675   679   679   685   686   696   697   697                 |
 |      700   703   704   709   712   717   717   720                             |
 |  CENSORED DEATHS                                                               |
 |      459   459   459   459   459                                               |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0.62MGM3 LUNGTX                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 7      UNCENSORED DEATHS 0      CENSORED DEATHS 7    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   199   199                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.25MGM3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 38     CENSORED DEATHS 5    TERMINAL 15        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      202   367   457   519   525   541   546   564   567   567                 |
 |      570   578   588   592   606   618   618   619   619   620                 |
 |      624   627   647   647   650   674   676   681   681   690                 |
 |      690   697   706   706   706   707   717   730                             |
 |  CENSORED DEATHS                                                               |
 |      459   459   459   459   459                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1.25MGM3 LUNGTX                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 7      UNCENSORED DEATHS 0      CENSORED DEATHS 7    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   199   199                                   |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 2.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 57     UNCENSORED DEATHS 40     CENSORED DEATHS 5    TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      467   468   475   536   539   544   545   553   565   570                 |
 |      570   570   578   583   594   595   615   615   623   624                 |
 |      625   625   633   647   651   660   660   665   665   671                 |
 |      671   676   679   697   707   707   709   717   719   723                 |
 |  CENSORED DEATHS                                                               |
 |      459   459   459   459   459                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 2.5MG/M3 LUNGTX                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 7      UNCENSORED DEATHS 0      CENSORED DEATHS 7    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      199   199   199   199   199   199   199                                   |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/M3    |   100.0 100.0  98.3  98.3  98.3  96.5  90.9  72.3  51.9  26.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |MG/M3 LUNGT|                                                                    |
 |           |                                                                    |
 |0.62MGM3   |   100.0 100.0 100.0 100.0 100.0  98.1  86.8  75.5  60.4  28.3      |
 |           |                                                                    |
 |           |                                                                    |
 |0.62MGM3   |   100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 |1.25MGM3   |   100.0 100.0  98.3  98.3  96.6  94.8  89.1  74.0  53.1  28.4      |
 |           |                                                                    |
 |           |                                                                    |
 |1.25MGM3   |   100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 |2.5MG/M3   |   100.0 100.0 100.0 100.0 100.0  94.2  86.5  69.2  44.2  23.1      |
 |           |                                                                    |
 |           |                                                                    |
 |2.5MG/M3   |   100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 MG/M3     0           0.62MGM3    0.62MGM3    1.25MGM3    1.25MGM3    2.5MG/M3    2.5MG/M3 |
 |                                            MG/M3 LUNGTX            LUNGTX                  LUNGTX                  LUNGTX   |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       26.0%        0.0%       28.3%        0.0%       28.4%        0.0%       23.1%        0.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.563      -----      P=0.773N    P=1.000N    P=1.000N    P=1.000N    P=0.719     P=1.000N |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       617.8          .        630.4          .        608.9          .        618.4          .     |
 |NATURAL DEATHS (C)      |       (15.1)      (  . )      (11.8)      (  . )      (16.6)      (  . )      (11.1)      (  . )   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       631.7       199.0       642.2       199.0       628.1       199.0       628.5       199.0    |
 |(STANDARD ERROR)        |       (13.8)      ( 0.0)      (12.2)      ( 0.0)      (14.7)      ( 0.0)      (12.1)      ( 0.0)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 32     CENSORED DEATHS 5    TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      348   354   403   468   468   553   558   563   564   586                 |
 |      594   607   618   622   624   636   640   643   644   655                 |
 |      664   678   689   692   699   713   713   714   714   715                 |
 |      727   727                                                                 |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 MG/M3 LUNGTX                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 7      UNCENSORED DEATHS 0      CENSORED DEATHS 7    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   200   200                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.62MGM3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 27     CENSORED DEATHS 5    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      423   472   475   509   524   536   536   537   600   614                 |
 |      622   629   634   640   652   660   667   668   674   678                 |
 |      703   707   719   721   722   725   725                                   |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460                                               |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0.62MGM3 LUNGTX                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 7      UNCENSORED DEATHS 0      CENSORED DEATHS 7    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   200   200                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.25MGM3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 33     CENSORED DEATHS 5    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      346   436   466   471   476   494   503   514   536   565                 |
 |      594   611   614   618   627   634   638   640   643   643                 |
 |      647   655   686   689   690   690   690   713   713   722                 |
 |      727   727   727                                                           |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1.25MGM3 LUNGTX                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 7      UNCENSORED DEATHS 0      CENSORED DEATHS 7    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |     NONE                                                                       |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   200   200                                   |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 2.5MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 27     CENSORED DEATHS 5    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      466   467   494   496   519   538   539   550   559   570                 |
 |      570   577   600   607   609   618   633   636   655   663                 |
 |      664   671   704   706   718   719   725                                   |
 |  CENSORED DEATHS                                                               |
 |      460   460   460   460   460                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 2.5MG/M3 LUNGTX                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 7      UNCENSORED DEATHS 1      CENSORED DEATHS 6    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      90                                                                        |
 |  CENSORED DEATHS                                                               |
 |      200   200   200   200   200   200                                         |
 |                                                                                |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/M3    |   100.0 100.0 100.0  96.6  94.8  91.0  91.0  79.7  60.7  39.8      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |MG/M3 LUNGT|                                                                    |
 |           |                                                                    |
 |0.62MGM3   |   100.0 100.0 100.0 100.0  98.3  94.5  85.0  83.2  69.9  49.1      |
 |           |                                                                    |
 |           |                                                                    |
 |0.62MGM3   |   100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 |1.25MGM3   |   100.0 100.0 100.0  98.3  98.3  90.9  83.3  79.5  58.7  37.9      |
 |           |                                                                    |
 |           |                                                                    |
 |1.25MGM3   |   100.0 100.0 100.0   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 |2.5MG/M3   |   100.0 100.0 100.0 100.0 100.0  96.2  86.8  75.5  60.4  49.1      |
 |           |                                                                    |
 |           |                                                                    |
 |2.5MG/M3   |    85.7  85.7  85.7   0.0   0.0   0.0   0.0   0.0   0.0   0.0      |
 |LUNGTX     |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                   NICKEL OXIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 MG/M3     0           0.62MGM3    0.62MGM3    1.25MGM3    1.25MGM3    2.5MG/M3    2.5MG/M3 |
 |                                            MG/M3 LUNGTX            LUNGTX                  LUNGTX                  LUNGTX   |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       39.8%        0.0%       49.1%        0.0%       37.9%        0.0%       49.1%        0.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.834N     -----      P=0.392N     -----      P=0.921      -----      P=0.563N    P=0.206  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       612.3          .        621.2          .        610.5          .        602.7        90.0    |
 |NATURAL DEATHS (C)      |       (18.6)      (  . )      (17.1)      (  . )      (17.2)      (  . )      (15.2)      (  . )   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       641.4       200.0       655.6       200.0       638.4       200.0       647.0       184.3    |
 |(STANDARD ERROR)        |       (14.5)      ( 0.0)      (13.1)      ( 0.0)      (14.2)      ( 0.0)      (13.1)      (15.7)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            NICKEL OXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/M3          = 1
                                                        0 MG/M3 LUNGTX   = 2
                                                        0.62MGM3         = 3
                                                        0.62MGM3 LUNGTX  = 4
                                                        1.25MGM3         = 5
                                                        1.25MGM3 LUNGTX  = 6
                                                        2.5MG/M3         = 7
                                                        2.5MG/M3 LUNGTX  = 8

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                             1 2                         5               31   3
      |                                                           5              571   11  1 7
P     |                                                                                    1 33  1
E     |                                                                                       37 11
R  80 +                                                                                          5111
C     |                                                                                           371 115 3
E     |                                                                                               7157133
N     |                                                                                                  711333
T  60 +                                                                                                    57 3   33
      |                                                                                                    17 51 1 33
S     |                                                                                                       7  1111 3
U     |                                                                                                          77 111
R  40 +                                                                                                           77 5333
V     |                                                                                                            7  1113
I     |                                                                                                                5111 3
V     |                                                                                                                  71 1
A  20 +
L     |
      |
      |
    0 +                                 2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 105 obs hidden.

                                                            NICKEL OXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/M3          = 1
                                                        0 MG/M3 LUNGTX   = 2
                                                        0.62MGM3         = 3
                                                        0.62MGM3 LUNGTX  = 4
                                                        1.25MGM3         = 5
                                                        1.25MGM3 LUNGTX  = 6
                                                        2.5MG/M3         = 7
                                                        2.5MG/M3 LUNGTX  = 8

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1             8                                        11          3 5    73
      |                                                         1       1    5    13  7 3  3
P     |                                                                           15  55   3 3 11
E     |               8                                        8                       5 5   3 7117 1  3 3
R  80 +                                                                                          5771 1 1313
C     |                                                                                            7   7751133 3
E     |                                                                                                 7 7111 3 33
N     |                                                                                                     71 1 133
T  60 +                                                                                                      555 17151 3 3
      |                                                                                                             5117133
S     |                                                                                                              5  573 3
U     |                                                                                                                 111
R  40 +                                                                                                                   1 1
V     |
I     |
V     |
A  20 +
L     |
      |
      |
    0 +                                                        2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 84 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.