National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1377

TDMS Study 05127-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                     BARIUM CHLORIDE DIHYDRATE


NTP Experiment-Test: 05127-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/16/94
Route: DOSED WATER                                                                                                Time: 21:44:58




       Facility:  TSI Mason Research

       Chemical CAS #:  10326279

       Lock Date:  11/15/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            7           10            6                                     
  Early Deaths                                                                                                                      
    Moribund                                           9           11            9           35                                     
    Dead                                               3            5            5            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           37           36           13                                     
    Dead                                               1                                                                            
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (54)         (55)         (56)         (54)                                   
      Autolysis                                                                  1 (2%)                                             
      Dilatation                                                    2 (4%)       1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
   Intestine Large, Colon                             (57)         (58)         (58)         (57)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Intestine Large, Rectum                            (58)         (59)         (59)         (60)                                   
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Cecum                             (58)         (58)         (57)         (55)                                   
      Edema                                            1 (2%)                                                                       
      Hyperplasia, Lymphoid                           39 (67%)     30 (52%)     35 (61%)     23 (42%)                               
   Intestine Small, Duodenum                          (57)         (57)         (58)         (54)                                   
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
   Intestine Small, Jejunum                           (57)         (57)         (56)         (54)                                   
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
   Intestine Small, Ileum                             (59)         (55)         (56)         (52)                                   
      Hyperplasia, Lymphoid                            2 (3%)                    3 (5%)                                             
      Ulcer                                                         1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Angiectasis                                      1 (2%)       2 (3%)       1 (2%)                                             
      Angiectasis, Focal                                                         1 (2%)                                             
      Basophilic Focus                                 3 (5%)                    2 (3%)       1 (2%)                                
      Clear Cell Focus                                 1 (2%)       4 (7%)       2 (3%)       2 (3%)                                
      Congestion                                                    1 (2%)                    1 (2%)                                
      Eosinophilic Focus                               4 (7%)       4 (7%)       9 (15%)      2 (3%)                                
      Fatty Change                                     8 (13%)     12 (20%)     10 (17%)      7 (12%)                               
      Granuloma                                        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       1 (2%)                                             
      Hemorrhage, Focal                                1 (2%)                    1 (2%)       1 (2%)                                
      Infarct                                                                    1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                    2 (3%)                                             
      Mineralization, Focal                            1 (2%)                                                                       
      Mixed Cell Focus                                              1 (2%)       2 (3%)       1 (2%)                                
      Necrosis, Focal                                  5 (8%)       6 (10%)      1 (2%)       4 (7%)                                
   Mesentery                                          (3)          (7)          (4)          (4)                                    
      Fibrosis                                                                   1 (25%)                                            
      Fat, Necrosis                                    3 (100%)     5 (71%)      4 (100%)     4 (100%)                              
   Pancreas                                           (60)         (59)         (60)         (60)                                   
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic, Focal                     4 (7%)       1 (2%)       2 (3%)       1 (2%)                                
      Acinus, Atrophy                                  2 (3%)                                                                       
      Duct, Ectasia                                                 1 (2%)                                                          
   Salivary Glands                                    (60)         (59)         (60)         (59)                                   
      Congestion                                                                              1 (2%)                                
      Inflammation, Chronic, Focal                     8 (13%)      3 (5%)       7 (12%)      4 (7%)                                
   Stomach, Forestomach                               (60)         (58)         (59)         (59)                                   
      Abscess                                          2 (3%)                                 1 (2%)                                
      Acanthosis                                                    2 (3%)                    5 (8%)                                
      Bulla                                            1 (2%)                                                                       
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Diverticulum                                     1 (2%)                    1 (2%)       2 (3%)                                
      Edema                                                         1 (2%)                                                          
      Hyperkeratosis                                                1 (2%)       2 (3%)       1 (2%)                                
      Ulcer                                            2 (3%)       1 (2%)       1 (2%)       4 (7%)                                
   Stomach, Glandular                                 (59)         (58)         (58)         (59)                                   
      Diverticulum                                     1 (2%)                                                                       
      Erosion                                          3 (5%)                    1 (2%)       1 (2%)                                
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Mineralization                                   1 (2%)                    2 (3%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Ulcer                                            1 (2%)       1 (2%)                                                          
      Mucosa, Hyperplasia                              1 (2%)                                                                       
   Tongue                                             (1)          (2)          (2)                                                 
      Angiectasis                                                                2 (100%)                                           
      Hyperkeratosis                                                2 (100%)                                                        
      Necrosis, Focal                                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                                2 (3%)       2 (3%)       1 (2%)                                
      Dilatation                                       1 (2%)                                                                       
      Edema                                                                      1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Pericardium, Fibrosis                                         1 (2%)                                                          
      Valve, Pigmentation                                                        2 (3%)                                             
      Ventricle, Hypertrophy                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (58)                                   
      Angiectasis                                                                1 (2%)                                             
      Congestion                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)       1 (2%)       2 (3%)                                             
      Capsule, Hyperplasia                                          1 (2%)                                                          
      Zona Reticularis, Degeneration, Fatty                                                   1 (2%)                                
      Zona Reticularis, Hemorrhage                                               3 (5%)                                             
      Zona Reticularis, Hyperplasia                                              1 (2%)                                             
   Islets, Pancreatic                                 (60)         (59)         (60)         (60)                                   
      Hyperplasia                                     14 (23%)     14 (24%)     13 (22%)      9 (15%)                               
   Parathyroid Gland                                  (38)         (44)         (40)         (40)                                   
      Hyperplasia                                                                1 (3%)                                             
   Pituitary Gland                                    (58)         (57)         (57)         (53)                                   
      Congestion                                                    2 (4%)                    1 (2%)                                
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal               11 (19%)      7 (12%)      6 (11%)      6 (11%)                               
      Rathke's Cleft, Hemorrhage                                    1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (59)         (59)                                   
      Atrophy                                          1 (2%)                                                                       
      Cyst                                                                       1 (2%)                                             
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      C-Cell, Hyperplasia                                           2 (3%)                                                          
      Follicle, Cyst                                   1 (2%)       1 (2%)                    1 (2%)                                
      Follicular Cell, Hyperplasia                     4 (7%)       6 (10%)      2 (3%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)                                    (2)                                    
      Cyst                                                                                    1 (50%)                               
   Ovary                                              (59)         (59)         (59)         (59)                                   
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                                                                 1 (2%)                                
      Congestion                                       1 (2%)                                 1 (2%)                                
      Cyst                                            18 (31%)     10 (17%)     13 (22%)     10 (17%)                               
      Hemorrhage                                       1 (2%)                                 3 (5%)                                
      Thrombosis                                                                 1 (2%)                                             
      Follicle, Hemorrhage                                          2 (3%)       1 (2%)                                             
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Angiectasis                                      3 (5%)       2 (3%)       3 (5%)                                             
      Atrophy                                                       4 (7%)       4 (7%)      20 (33%)                               
      Cyst                                                          1 (2%)                                                          
      Dilatation                                      17 (28%)     14 (23%)     15 (25%)      6 (10%)                               
      Hemorrhage                                       2 (3%)                    1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                       1 (2%)       1 (2%)                                                          
      Endometrium, Cyst                                                                       2 (3%)                                
      Endometrium, Hyperplasia, Cystic                48 (80%)     43 (72%)     42 (70%)     26 (43%)                               
      Endometrium, Metaplasia, Squamous                                          1 (2%)                                             
      Lumen, Hemorrhage                                             1 (2%)                                                          
      Myometrium, Inflammation, Chronic, Focal         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (43)         (1)          (25)         (13)                                   
      Neutrophilia                                     1 (2%)                    1 (4%)                                             
   Bone Marrow                                        (59)         (60)         (59)         (58)                                   
      Atrophy                                                       1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Megakaryocyte                                                              1 (2%)                                
      Hyperplasia, Neutrophil                          3 (5%)       4 (7%)       2 (3%)       3 (5%)                                
      Myelofibrosis                                   37 (63%)     35 (58%)     33 (56%)     18 (31%)                               
   Lymph Node                                         (6)          (5)          (8)          (2)                                    
      Lumbar, Infiltration Cellular, Plasma Cell                                 2 (25%)                                            
      Lumbar, Inflammation, Acute                                                1 (13%)                                            
      Lumbar, Lymphatic, Angiectasis                                             2 (25%)                                            
      Mediastinal, Congestion                          1 (17%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid                            1 (20%)                                                         
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                   1 (13%)                                            
   Lymph Node, Mandibular                             (58)         (58)         (59)         (46)                                   
      Depletion Lymphoid                                                                      2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
      Lymphatic, Angiectasis                                        2 (3%)                                                          
   Lymph Node, Mesenteric                             (58)         (55)         (59)         (45)                                   
      Angiectasis                                                                             1 (2%)                                
      Congestion                                                    2 (4%)                    1 (2%)                                
      Depletion Lymphoid                                                                     10 (22%)                               
      Hyperplasia, Lymphoid                            2 (3%)                                                                       
      Necrosis, Focal                                               1 (2%)                                                          
      Lymphatic, Angiectasis                                        2 (4%)                                                          
   Spleen                                             (60)         (60)         (58)         (58)                                   
      Amyloid Deposition                                            2 (3%)                                                          
      Congestion                                                    3 (5%)       2 (3%)       2 (3%)                                
      Depletion Lymphoid                               2 (3%)       2 (3%)                   11 (19%)                               
      Fibrosis                                                                   1 (2%)       3 (5%)                                
      Hematopoietic Cell Proliferation                12 (20%)     11 (18%)     13 (22%)     10 (17%)                               
      Hyperplasia, Lymphoid                                         1 (2%)       2 (3%)                                             
      Infarct                                                                    1 (2%)                                             
      Necrosis, Focal                                               2 (3%)       1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)       1 (2%)                    2 (3%)                                
   Thymus                                             (51)         (52)         (56)         (44)                                   
      Depletion Lymphoid                               1 (2%)       1 (2%)                   12 (27%)                               
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
      Necrosis, Focal                                               1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (41)         (58)         (47)                                   
      Ectasia                                          1 (2%)                                                                       
   Skin                                               (60)         (59)         (60)         (59)                                   
      Congestion                                                                 1 (2%)                                             
      Edema                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                                                              
      Necrosis                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                      1 (2%)                                                                       
      Mineralization                                  27 (45%)     30 (50%)     30 (50%)     24 (40%)                               
      Mineralization, Focal                            4 (7%)       4 (7%)       3 (5%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                    2 (3%)       1 (2%)       2 (3%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                    2 (3%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Alveolar Epithelium, Metaplasia                               1 (2%)                    3 (5%)                                
      Peribronchial, Inflammation, Chronic                          1 (2%)                                                          
   Nose                                               (59)         (60)         (59)         (60)                                   
      Degeneration, Hyaline                            1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
      Inflammation, Acute                                           1 (2%)                    1 (2%)                                
      Inflammation, Chronic                           45 (76%)     44 (73%)     41 (69%)     36 (60%)                               
      Inflammation, Chronic, Focal                    10 (17%)      3 (5%)       9 (15%)      6 (10%)                               
      Metaplasia, Squamous                                                       4 (7%)       4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Artery, Internal Ear, Inflammation, Chronic      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                                            2 (3%)                                                          
      Atrophy, Focal                                   2 (3%)       2 (3%)       4 (7%)       1 (2%)                                
      Casts                                                                      1 (2%)       1 (2%)                                
      Congestion                                                    1 (2%)       1 (2%)                                             
      Crystals                                                                               36 (60%)                               
      Glomerulosclerosis                               1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Focal                                                        1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)                                             
      Mineralization                                   3 (5%)                    1 (2%)       2 (3%)                                
      Nephropathy                                                   2 (3%)       1 (2%)      37 (62%)                               
      Papilla, Necrosis                                             1 (2%)                                                          
      Renal Tubule, Degeneration                                    2 (3%)                                                          
      Renal Tubule, Dilatation                                      2 (3%)       1 (2%)       2 (3%)                                
      Renal Tubule, Pigmentation, Hemosiderin                       1 (2%)                                                          
      Renal Tubule, Regeneration                       6 (10%)      6 (10%)      9 (15%)      2 (3%)                                
   Urinary Bladder                                    (57)         (53)         (56)         (54)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic, Focal                     4 (7%)       2 (4%)       4 (7%)       3 (6%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           59           60                                     
  Scheduled Sacrifice                                  9           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           5            5            6           10                                     
    Dead                                               1            2            4            8                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                44           43           38           32                                     
    Moribund                                                                     1                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    60           60           59           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (53)         (57)         (56)         (50)                                   
      Degeneration, Hyaline                                                      1 (2%)                                             
      Dilatation                                       3 (6%)                    1 (2%)       1 (2%)                                
   Intestine Large, Colon                             (55)         (58)         (57)         (56)                                   
      Parasite Metazoan                                                                       1 (2%)                                
   Intestine Large, Rectum                            (56)         (58)         (56)         (57)                                   
      Parasite Metazoan                                                                       1 (2%)                                
   Intestine Large, Cecum                             (57)         (59)         (57)         (56)                                   
      Hyperplasia, Lymphoid                           29 (51%)     34 (58%)     39 (68%)      9 (16%)                               
      Serosa, Fibrosis                                 1 (2%)                                                                       
   Intestine Small, Jejunum                           (58)         (58)         (56)         (54)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
   Intestine Small, Ileum                             (58)         (53)         (56)         (54)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)       1 (2%)                                
   Liver                                              (60)         (60)         (58)         (60)                                   
      Angiectasis                                                   3 (5%)                                                          
      Basophilic Focus                                 2 (3%)       1 (2%)                                                          
      Clear Cell Focus                                 8 (13%)     13 (22%)      5 (9%)       2 (3%)                                
      Clear Cell Focus, Multiple                                    1 (2%)                                                          
      Congestion                                                                 1 (2%)                                             
      Eosinophilic Focus                               9 (15%)      9 (15%)      3 (5%)       5 (8%)                                
      Fatty Change                                     9 (15%)      9 (15%)     13 (22%)     11 (18%)                               
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hemorrhage                                                                              2 (3%)                                
      Infarct                                                                    1 (2%)                                             
      Mixed Cell Focus                                              1 (2%)                                                          
      Necrosis, Focal                                  4 (7%)       2 (3%)       3 (5%)       1 (2%)                                
      Nuclear Alteration                               1 (2%)                                 1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Fibrosis                                                           1 (2%)                                             
      Artery, Thrombosis                                                         1 (2%)                                             
      Bile Duct, Hyperplasia                                                     1 (2%)                                             
   Mesentery                                          (3)          (1)          (1)          (2)                                    
      Fibrosis                                                      1 (100%)                                                        
      Inflammation, Chronic                            1 (33%)                                                                      
      Inflammation, Granulomatous                                                1 (100%)     1 (50%)                               
      Fat, Necrosis                                    1 (33%)      1 (100%)                  1 (50%)                               
   Pancreas                                           (59)         (60)         (58)         (60)                                   
      Congestion                                                                 1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Serosa, Necrosis                                 1 (2%)                                                                       
   Pharynx                                            (1)          (1)                                                              
      Developmental Malformation                       1 (100%)                                                                     
   Salivary Glands                                    (60)         (60)         (59)         (60)                                   
      Inflammation, Chronic, Focal                     2 (3%)       2 (3%)       3 (5%)       1 (2%)                                
   Stomach, Forestomach                               (59)         (60)         (58)         (58)                                   
      Acanthosis                                       1 (2%)                    3 (5%)       1 (2%)                                
      Diverticulum                                     1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)       3 (5%)                                                          
      Hyperplasia, Squamous                                                                   1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Ulcer                                            2 (3%)                                 1 (2%)                                
   Stomach, Glandular                                 (59)         (60)         (57)         (57)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Diverticulum                                                               1 (2%)                                             
      Erosion                                                       1 (2%)                                                          
      Hyperplasia, Focal                               1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Metaplasia, Squamous                             1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
      Necrosis, Focal                                                            1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
   Tongue                                             (2)          (1)                                                              
      Depletion Cellular                               1 (50%)                                                                      
      Hemorrhage, Focal                                             1 (100%)                                                        
      Pigmentation                                     1 (50%)                                                                      
   Tooth                                                           (1)                                                              
      Hypertrophy                                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (59)         (60)                                   
      Cardiomyopathy                                                                          1 (2%)                                
      Dilatation                                       3 (5%)                                 1 (2%)                                
      Mineralization                                   1 (2%)                                                                       
      Perivascular, Inflammation, Chronic              1 (2%)                                                                       
      Valve, Pigmentation                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (60)         (57)         (58)                                   
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Atrophy                                                                                 1 (2%)                                
      Congestion                                                                 1 (2%)       1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Cytoplasmic Alteration, Focal                                 1 (2%)                                                          
      Hyperplasia                                      2 (3%)       2 (3%)       2 (4%)       3 (5%)                                
      Hyperplasia, Focal                              15 (26%)     17 (28%)     14 (25%)      5 (9%)                                
      Hypertrophy, Focal                                            1 (2%)       3 (5%)       1 (2%)                                
      Capsule, Hyperplasia                                                       2 (4%)                                             
   Adrenal Medulla                                    (55)         (57)         (54)         (56)                                   
      Hemorrhage                                                                              1 (2%)                                
   Islets, Pancreatic                                 (59)         (60)         (56)         (60)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia                                     27 (46%)     29 (48%)     25 (45%)     21 (35%)                               
      Hypoplasia                                                                              1 (2%)                                
   Pituitary Gland                                    (56)         (57)         (54)         (52)                                   
      Congestion                                       1 (2%)                    1 (2%)       1 (2%)                                
      Pars Distalis, Cyst                                           2 (4%)       1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                             1 (2%)                                                          
   Thyroid Gland                                      (59)         (57)         (58)         (58)                                   
      Follicle, Cyst                                   1 (2%)                                 1 (2%)                                
      Follicular Cell, Hyperplasia, Focal              1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (59)         (59)         (60)                                   
      Fibrosis, Focal                                               1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)       1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Penis                                                                                     (1)                                    
      Inflammation, Acute                                                                     1 (100%)                              
   Preputial Gland                                    (34)         (41)         (30)         (37)                                   
      Abscess                                          1 (3%)                                                                       
      Cyst                                            17 (50%)     23 (56%)     22 (73%)     20 (54%)                               
      Cyst, Multiple                                   1 (3%)                                                                       
      Cyst, Two                                        3 (9%)       1 (2%)       1 (3%)       8 (22%)                               
      Ectasia                                         21 (62%)     21 (51%)     12 (40%)     16 (43%)                               
      Inflammation, Acute, Focal                       1 (3%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (3%)                                                                       
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
   Prostate                                           (59)         (57)         (57)         (59)                                   
      Cyst                                                                                    1 (2%)                                
      Dilatation                                                    1 (2%)                                                          
      Hemorrhage, Focal                                                                       1 (2%)                                
      Inflammation, Chronic                            2 (3%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                    2 (4%)       1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
   Seminal Vesicle                                    (59)         (60)         (59)         (60)                                   
      Atrophy                                                                    1 (2%)                                             
      Congestion                                                                 1 (2%)                                             
      Dilatation                                      11 (19%)     11 (18%)     10 (17%)      2 (3%)                                
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
   Testes                                             (60)         (60)         (59)         (60)                                   
      Interstitial Cell, Hyperplasia                                             2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (49)         (1)          (27)         (22)                                   
      Neutrophilia                                                                            2 (9%)                                
   Bone Marrow                                        (59)         (60)         (57)         (58)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Neutrophil                          1 (2%)                    2 (4%)       4 (7%)                                
      Myelofibrosis                                                              1 (2%)       1 (2%)                                
   Lymph Node, Mandibular                             (41)         (50)         (51)         (43)                                   
      Lymphatic, Angiectasis                           1 (2%)       2 (4%)                                                          
   Lymph Node, Mesenteric                             (58)         (57)         (56)         (49)                                   
      Congestion                                       3 (5%)       1 (2%)       1 (2%)       2 (4%)                                
      Depletion Lymphoid                                            1 (2%)                    4 (8%)                                
      Hyperplasia, Lymphoid                            4 (7%)                                                                       
      Infiltration Cellular, Plasma Cell               1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Inflammation, Granulomatous                                                1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis, Focal                                  1 (2%)                    2 (4%)       1 (2%)                                
      Lymphatic, Angiectasis                                        1 (2%)                                                          
   Spleen                                             (59)         (60)         (58)         (60)                                   
      Angiectasis                                                                             1 (2%)                                
      Congestion                                                    1 (2%)       4 (7%)                                             
      Depletion Lymphoid                                            8 (13%)      4 (7%)      10 (17%)                               
      Developmental Malformation                                                 1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 7 (12%)     11 (18%)     11 (19%)      6 (10%)                               
      Necrosis, Focal                                                            2 (3%)                                             
   Thymus                                             (48)         (51)         (51)         (45)                                   
      Cyst                                             1 (2%)                                                                       
      Depletion Lymphoid                                                         2 (4%)       5 (11%)                               
      Necrosis, Focal                                                            1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (59)         (59)                                   
      Congestion                                                                 1 (2%)                                             
      Edema                                                                                   1 (2%)                                
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Chronic Active                                                            1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Pigmentation                                                                            1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
      Subcutaneous Tissue, Necrosis                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (58)         (60)                                   
      Mineralization                                  25 (42%)     25 (42%)     22 (38%)     35 (58%)                               
      Mineralization, Focal                            1 (2%)       7 (12%)      7 (12%)      4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (59)         (60)                                   
      Congestion                                       1 (2%)                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic, Focal                                                            1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05127-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:44:58  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Granulomatous                                                1 (2%)       1 (2%)                                
      Pigmentation                                                  1 (2%)                                                          
      Alveolar Epithelium, Metaplasia                  2 (3%)       3 (5%)       2 (3%)       4 (7%)                                
   Nose                                               (60)         (60)         (58)         (60)                                   
      Inflammation, Acute, Focal                                                              1 (2%)                                
      Inflammation, Chronic                           42 (70%)     43 (72%)     31 (53%)     42 (70%)                               
      Inflammation, Chronic, Focal                     6 (10%)      4 (7%)      10 (17%)      9 (15%)                               
      Metaplasia, Squamous                                          1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (58)         (60)                                   
      Atrophy, Focal                                                4 (7%)       4 (7%)                                             
      Autolysis                                                                  1 (2%)                                             
      Casts                                                         1 (2%)                                                          
      Congestion                                                                 1 (2%)                                             
      Crystals                                                                   1 (2%)      22 (37%)                               
      Cyst                                             4 (7%)       1 (2%)       4 (7%)       2 (3%)                                
      Glomerulosclerosis                                                         1 (2%)                                             
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Chronic, Focal                                  1 (2%)       2 (3%)                                             
      Mineralization                                  28 (47%)     33 (55%)     32 (55%)     36 (60%)                               
      Mineralization, Focal                            1 (2%)       1 (2%)       4 (7%)       2 (3%)                                
      Nephropathy                                      1 (2%)                    2 (3%)      19 (32%)                               
      Cortex, Cyst                                     1 (2%)                                                                       
      Renal Tubule, Cyst                                            1 (2%)                                                          
      Renal Tubule, Degeneration                                    1 (2%)       1 (2%)                                             
      Renal Tubule, Dilatation                                      1 (2%)       2 (3%)                                             
      Renal Tubule, Mineralization                     1 (2%)                                                                       
      Renal Tubule, Regeneration                      33 (56%)     33 (55%)     37 (64%)     30 (50%)                               
   Urinary Bladder                                    (58)         (59)         (55)         (55)                                   
      Inflammation, Chronic, Focal                     2 (3%)                    1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.