National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1381

TDMS Study 05127-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                     BARIUM CHLORIDE DIHYDRATE


NTP Experiment-Test: 05127-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/16/94
Route: DOSED WATER                                                                                                Time: 21:45:01




       Facility:  TSI Mason Research

       Chemical CAS #:  10326279

       Lock Date:  11/15/91

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            7           10            6                                     
  Early Deaths                                                                                                                      
    Moribund                                           9           11            9           35                                     
    Dead                                               3            5            5            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           37           36           13                                     
    Dead                                               1                                                                            
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (54)         (55)         (56)         (54)                                   
   Intestine Large, Colon                             (57)         (58)         (58)         (57)                                   
   Intestine Large, Rectum                            (58)         (59)         (59)         (60)                                   
   Intestine Large, Cecum                             (58)         (58)         (57)         (55)                                   
      Leiomyoma                                                     2 (3%)                                                          
   Intestine Small, Duodenum                          (57)         (57)         (58)         (54)                                   
   Intestine Small, Jejunum                           (57)         (57)         (56)         (54)                                   
      Adenocarcinoma                                                                          1 (2%)                                
   Intestine Small, Ileum                             (59)         (55)         (56)         (52)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       2 (3%)                                                          
      Hepatocellular Carcinoma                         4 (7%)       2 (3%)       6 (10%)      1 (2%)                                
      Hepatocellular Adenoma                          10 (17%)     12 (20%)     11 (18%)      4 (7%)                                
      Hepatocellular Adenoma, Multiple                 3 (5%)       2 (3%)       4 (7%)       1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Mesentery                                          (3)          (7)          (4)          (4)                                    
      Fibrosarcoma                                                  1 (14%)                                                         
      Fibrosarcoma, Metastatic                                      1 (14%)                                                         
   Pancreas                                           (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Salivary Glands                                    (60)         (59)         (60)         (59)                                   
   Stomach, Forestomach                               (60)         (58)         (59)         (59)                                   
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (59)         (58)         (58)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (58)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Adenoma, Two                                     1 (2%)                                                                       
      Capsule, Adenoma                                              1 (2%)                                                          
   Adrenal Medulla                                    (58)         (55)         (56)         (56)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (60)         (59)         (60)         (60)                                   
      Adenoma                                                                    3 (5%)                                             
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (58)         (57)         (57)         (53)                                   
      Pars Distalis, Adenoma                           9 (16%)      6 (11%)      5 (9%)       2 (4%)                                
      Pars Distalis, Carcinoma                                                   2 (4%)                                             
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (59)         (59)                                   
      Adenoma                                                                    1 (2%)                                             
      C-Cell, Adenoma                                  1 (2%)                                                                       
      Follicular Cell, Adenoma                                      1 (2%)                    2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)                                    (2)                                    
   Ovary                                              (59)         (59)         (59)         (59)                                   
      Cystadenoma                                                                3 (5%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangioma                                                                 1 (2%)                                             
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Polyp Stromal                                    3 (5%)       1 (2%)       4 (7%)                                             
      Sarcoma Stromal                                               1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (59)         (58)                                   
   Lymph Node                                         (6)          (5)          (8)          (2)                                    
   Lymph Node, Mandibular                             (58)         (58)         (59)         (46)                                   
   Lymph Node, Mesenteric                             (58)         (55)         (59)         (45)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Spleen                                             (60)         (60)         (58)         (58)                                   
      Hemangiosarcoma                                               2 (3%)       2 (3%)       1 (2%)                                
   Thymus                                             (51)         (52)         (56)         (44)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (59)         (60)         (59)                                   
      Fibrosarcoma                                     3 (5%)       1 (2%)       1 (2%)       3 (5%)                                
      Hemangiosarcoma                                                                         1 (2%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic                                      1 (2%)                                                          
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)                                                              
      Fibrosarcoma, Metastatic                                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Pituitary Gland                                     2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     4 (7%)       2 (3%)       3 (5%)       2 (3%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       2 (3%)                                             
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Fibrosarcoma, Metastatic                                      1 (2%)       1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma, Metastatic             1 (2%)       1 (2%)       2 (3%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Nose                                               (59)         (60)         (59)         (60)                                   
                                                             Page   4                                                               
NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (1)                                                              
      Carcinoma                                        1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (57)         (53)         (56)         (54)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Lymphoma Malignant Histiocytic                   1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)       4 (7%)       1 (2%)                                
      Lymphoma Malignant Mixed                        13 (22%)      9 (15%)      9 (15%)      4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          33          40          18                                       
     Total Primary Neoplasms                           60          52          67          28                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26          21          28          11                                       
     Total Benign Neoplasms                            34          27          39          13                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          20          26          11                                       
     Total Malignant Neoplasms                         26          25          28          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           5           1                                       
     Total Metastatic Neoplasm                          8           6           5           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           59           60                                     
  Scheduled Sacrifice                                  9           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           5            5            6           10                                     
    Dead                                               1            2            4            8                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                44           43           38           32                                     
    Moribund                                                                     1                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    60           60           59           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (53)         (57)         (56)         (50)                                   
   Intestine Large, Cecum                             (57)         (59)         (57)         (56)                                   
   Intestine Small, Duodenum                          (57)         (58)         (55)         (55)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (58)         (58)         (56)         (54)                                   
      Adenocarcinoma                                   1 (2%)                                 1 (2%)                                
   Intestine Small, Ileum                             (58)         (53)         (56)         (54)                                   
   Liver                                              (60)         (60)         (58)         (60)                                   
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Hemangiosarcoma                                  2 (3%)       1 (2%)                    1 (2%)                                
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                         5 (8%)       7 (12%)      7 (12%)      3 (5%)                                
      Hepatocellular Adenoma                          13 (22%)     15 (25%)     12 (21%)     10 (17%)                               
      Hepatocellular Adenoma, Multiple                12 (20%)      6 (10%)      5 (9%)                                             
      Sarcoma                                                                    1 (2%)                                             
      Sarcoma, Metastatic                                                        1 (2%)                                             
   Pancreas                                           (59)         (60)         (58)         (60)                                   
      Hepatocellular Carcinoma, Metastatic                                       1 (2%)                                             
      Sarcoma, Metastatic                                                        1 (2%)                                             
      Acinus, Adenoma                                  1 (2%)                                                                       
   Pharynx                                            (1)          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
   Salivary Glands                                    (60)         (60)         (59)         (60)                                   
   Stomach, Forestomach                               (59)         (60)         (58)         (58)                                   
      Sarcoma, Metastatic                                                        1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (59)         (60)                                   
      Hemangioma                                                                 1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (60)         (57)         (58)                                   
      Adenoma                                                                    1 (2%)                                             
      Capsule, Adenoma                                                           3 (5%)                                             
   Islets, Pancreatic                                 (59)         (60)         (56)         (60)                                   
      Adenoma                                          3 (5%)                    2 (4%)       1 (2%)                                
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (56)         (57)         (54)         (52)                                   
      Pars Distalis, Adenoma                           1 (2%)       1 (2%)       2 (4%)                                             
   Thyroid Gland                                      (59)         (57)         (58)         (58)                                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                    (2)                                    
      Hemangiosarcoma, Metastatic                                                             1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (59)         (59)         (60)                                   
      Sarcoma                                                                                 1 (2%)                                
   Prostate                                           (59)         (57)         (57)         (59)                                   
   Seminal Vesicle                                    (59)         (60)         (59)         (60)                                   
   Testes                                             (60)         (60)         (59)         (60)                                   
      Interstitial Cell, Adenoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (57)         (58)                                   
   Lymph Node                                         (2)                       (4)                                                 
   Lymph Node, Mandibular                             (41)         (50)         (51)         (43)                                   
   Lymph Node, Mesenteric                             (58)         (57)         (56)         (49)                                   
      Hepatocellular Carcinoma, Metastatic                                       1 (2%)                                             
      Sarcoma, Metastatic                                                        1 (2%)                                             
   Spleen                                             (59)         (60)         (58)         (60)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                    2 (3%)       2 (3%)                                
   Thymus                                             (48)         (51)         (51)         (45)                                   
                                                             Page   8                                                               
NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (59)         (59)                                   
      Fibroma                                          1 (2%)                                 1 (2%)                                
      Fibrosarcoma                                                                            1 (2%)                                
      Hemangioma                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (59)         (60)                                   
      Sarcoma, Metastatic                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (59)         (60)                                   
      Alveolar/Bronchiolar Adenoma                    14 (23%)     10 (17%)      7 (12%)      6 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma, Two                1 (2%)                    1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                 3 (5%)                                
      Carcinoma, Metastatic                            2 (3%)                                                                       
      Hepatocellular Carcinoma, Metastatic                                       1 (2%)       2 (3%)                                
      Sarcoma, Metastatic                                                        2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (6)          (2)          (2)          (2)                                    
      Adenoma                                          5 (83%)      2 (100%)     1 (50%)      2 (100%)                              
      Carcinoma                                        1 (17%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (58)         (60)                                   
   Urinary Bladder                                    (58)         (59)         (55)         (55)                                   
      Hemangioma                                                                 1 (2%)                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(59)        *(60)                                   
      Lymphoma Malignant                               1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                   2 (3%)                                                                       
      Lymphoma Malignant Lymphocytic                                1 (2%)       2 (3%)       1 (2%)                                
      Lymphoma Malignant Mixed                         5 (8%)       2 (3%)       8 (14%)      2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05127-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 21:45:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          36          34          29                                       
     Total Primary Neoplasms                           71          51          58          40                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38          31          27          21                                       
     Total Benign Neoplasms                            52          37          37          25                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          13          17          13                                       
     Total Malignant Neoplasms                         19          14          21          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       2           3                                       
     Total Metastatic Neoplasm                          3                      10           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.