Share This:
https://ntp.niehs.nih.gov/go/1387

TDMS Study 05127-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/16/94   
EXP: 05127                BARIUM CHLORIDE DIHYDRATE            TIME: 22:02:33   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED WATER                 NTP C#: C61074   
CONT: N01ES55115                                               CAS: 10326279    
PATHOLOGIST: A. RUSSFIELD                    S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/16/94  
EXP: 05127                BARIUM CHLORIDE DIHYDRATE            TIME: 22:02:33  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED WATER                 NTP C#: C61074  
CONT: N01ES55115                                               CAS: 10326279   
PATHOLOGIST: A. RUSSFIELD                    S. EUSTIS                         

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 725 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 6      CENSORED DEATHS 9    TERMINAL 45        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      303   406   492   596   693   717                                         |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   459   459   459                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 7      CENSORED DEATHS 10   TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      520   529   578   602   641   661   675                                   |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1250 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 10     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      403   442   457   588   613   629   666   669   695   720                 |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   459   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 725 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 2500 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 10   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      23    261   399   469   483   494   518   567   602   605                 |
 |      605   626   627   631   659   664   675   720                             |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   459   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 725 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   725 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0  98.3  96.7  96.7  94.7  92.7  92.7  88.8      |
 |           |                                                                    |
 |           |                                                                    |
 |500 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  92.0  88.0  86.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1250 PPM   |   100.0 100.0 100.0 100.0  98.3  94.9  94.9  92.9  88.7  80.5      |
 |           |                                                                    |
 |           |                                                                    |
 |2500 PPM   |    98.3  98.3  96.7  96.7  95.0  91.0  86.9  78.8  68.7  64.7      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        500 PPM      1250 PPM     2500 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       88.8%        86.0%        80.5%        64.7%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.001      P=0.977      P=0.378      P=0.009  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       534.5        600.9        588.2        534.9    |
 |NATURAL DEATHS (C)      |       (66.9)       (23.4)       (36.0)       (40.1)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       665.9        666.0        656.6        623.5    |
 |(STANDARD ERROR)        |       (14.9)       (13.4)       (14.7)       (18.7)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 12     CENSORED DEATHS 10   TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      478   498   541   561   573   580   602   605   665   675                 |
 |      692   722                                                                 |
 |  CENSORED DEATHS                                                               |
 |      462   462   462   462   462   462   464   464   464   464                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 7    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      373   377   380   455   462   467   535   561   564   607                 |
 |      616   645   655   703   719   721                                         |
 |  CENSORED DEATHS                                                               |
 |      464   464   464   464   464   464   464                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1250 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 14     CENSORED DEATHS 10   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      360   429   605   609   616   627   645   680   685   707                 |
 |      714   720   721   723                                                     |
 |  CENSORED DEATHS                                                               |
 |      462   462   462   462   462   462   464   464   464   464                 |
 |                                                                                |
 ==================================================================================

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 2500 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 41     CENSORED DEATHS 6    TERMINAL 13        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      104   106   108   112   135   135   142   142   150   157                 |
 |      171   173   177   203   213   221   225   230   234   248                 |
 |      248   298   317   395   412   436   561   585   617   643                 |
 |      643   658   658   666   673   674   679   707   718   720                 |
 |      723                                                                       |
 |  CENSORED DEATHS                                                               |
 |      462   462   462   464   464   464                                         |
 |                                                                                |
 ==================================================================================

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0 100.0  98.0  94.0  84.0  82.0  76.0      |
 |           |                                                                    |
 |           |                                                                    |
 |500 PPM    |   100.0 100.0 100.0 100.0  95.0  89.8  87.8  84.0  76.4  70.7      |
 |           |                                                                    |
 |           |                                                                    |
 |1250 PPM   |   100.0 100.0 100.0  98.3  98.3  96.7  96.7  94.7  86.6  72.5      |
 |           |                                                                    |
 |           |                                                                    |
 |2500 PPM   |   100.0  78.3  65.0  61.7  58.3  56.7  56.7  52.6  42.5  26.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        500 PPM      1250 PPM     2500 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       76.0%        70.7%        72.5%        26.3%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.535      P=0.911      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       599.3        552.5        631.5        376.0    |
 |NATURAL DEATHS (C)      |       (22.1)       (30.5)       (29.5)       (36.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       662.5        654.7        665.5        462.5    |
 |(STANDARD ERROR)        |       (14.2)       (15.8)       (14.6)       (31.2)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                     BARIUM CHLORIDE DIHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        500 PPM          = 2
                                                        1250 PPM         = 3
                                                        2500 PPM         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1   4                                           1               3                  2
      |     4                                     4     1               1     3
      |                                                                                    22
      |                                           4                    41     3  3    1     2      2
   95 +                                                                4         34   1             3  1
      |                                                                                            2   2
P     |                                                                           4 4               3  1 3   2       1
E     |                                                                             4 4                  3 3         1   1
R  90 +                                                                                                      2   2
C     |                                                                               4  4                 3      3      11
E     |                                                                                  4       4               2 2
N     |                                                                                                            2      2
T  85 +                                                                                          4     4          3   3
      |
S     |                                                                                                44             3  3
U     |
R  80 +                                                                                                                  33
V     |                                                                                                 4  4
I     |
V     |
A  75 +                                                                                                    44
L     |
      |                                                                                                     4    4
      |
   70 +
      |                                                                                                          4 4
      |
      |                                                                                                            4     4
   65 +                                                                                                                  44
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.

                                                     BARIUM CHLORIDE DIHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        500 PPM          = 2
                                                        1250 PPM         = 3
                                                        2500 PPM         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                4                                       3 2                1
      |                  44                                      3 2 2      3       1  1                3
      |                                                              2          2      1      1  1
      |                   4   4                                                 222              11     33
   90 +                       44                                                  2          2    11     3 3
      |                        44                                                            2   2 1   1   3  3     3
      |                         44                                                               2     11        1
      |                          4  4                                                                   22       1 13  3
P  80 +                             44                                                                   2    2    1 1 33
E     |                              4  4 4                                                                   22     1 2331
R     |                                   44                                                                           2 21 1
C     |                                    44                                                                             3 3
E  70 +                                     44                                                                           2  2
N     |                                      4  4
T     |                                         4      4
      |                                                4   4           4
S  60 +                                                                4 4
U     |                                                                  4   4                   4
R     |                                                                                          4  4
V     |                                                                                             4     4
I  50 +                                                                                                   4  4
V     |                                                                                                      4 4
A     |
L     |                                                                                                        4  4
   40 +                                                                                                           44
      |
      |                                                                                                            4   4
      |                                                                                                                4 4
   30 +
      |                                                                                                                  44 4
      |
      |
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.