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TDMS Study 05127-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                     BARIUM CHLORIDE DIHYDRATE


NTP Experiment-Test: 05127-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/16/94
Route: DOSED WATER                                                                                                Time: 18:45:47




       Facility:  TSI Mason Research

       Chemical CAS #:  10326279

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          14           11            9           16                                     
    Dead                                               5            3            2            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           36           39           32                                     
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (57)         (58)         (59)         (60)                                   
      Edema                                                                                   1 (2%)                                
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
      Parasite Metazoan                                1 (2%)       1 (2%)       4 (7%)       3 (5%)                                
      Muscularis, Hypertrophy                                                    1 (2%)       1 (2%)                                
   Intestine Large, Colon                             (57)         (57)         (60)         (59)                                   
      Parasite Metazoan                                5 (9%)       3 (5%)       8 (13%)      5 (8%)                                
   Intestine Large, Rectum                            (57)         (57)         (60)         (59)                                   
      Parasite Metazoan                                8 (14%)     13 (23%)     11 (18%)      8 (14%)                               
   Intestine Small, Duodenum                          (57)         (58)         (60)         (60)                                   
      Parasite Metazoan                                                          1 (2%)                                             
      Artery, Inflammation, Acute                                                1 (2%)                                             
   Intestine Small, Ileum                             (57)         (57)         (59)         (60)                                   
      Autolysis                                                                               1 (2%)                                
   Intestine Small, Jejunum                           (56)         (57)         (59)         (60)                                   
      Parasite Metazoan                                1 (2%)                                                                       
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                    2 (3%)       2 (3%)                                
      Basophilic Focus                                39 (65%)     43 (72%)     41 (68%)     40 (67%)                               
      Clear Cell Focus                                 6 (10%)      4 (7%)       8 (13%)     11 (18%)                               
      Congestion                                       1 (2%)                    1 (2%)                                             
      Cytoplasmic Alteration, Focal                                                           1 (2%)                                
      Developmental Malformation                       2 (3%)       5 (8%)       5 (8%)       2 (3%)                                
      Fatty Change                                    13 (22%)     10 (17%)      8 (13%)     10 (17%)                               
      Granuloma                                       17 (28%)     21 (35%)     17 (28%)     14 (23%)                               
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       7 (12%)      3 (5%)       3 (5%)       6 (10%)                               
      Hepatodiaphragmatic Nodule, Two                  2 (3%)                                                                       
      Inflammation, Acute, Focal                                                              1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Necrosis, Focal                                                                         1 (2%)                                
      Bile Duct, Hyperplasia                           6 (10%)      7 (12%)      9 (15%)      9 (15%)                               
      Hepatocyte, Hyperplasia, Focal                   5 (8%)                                 1 (2%)                                
      Perivascular, Inflammation, Chronic              3 (5%)                                 5 (8%)                                
      Serosa, Fibrosis                                 1 (2%)                                                                       
   Mesentery                                          (4)          (1)          (3)                                                 
      Accessory Spleen                                                           1 (33%)                                            
      Artery, Inflammation, Chronic                                              1 (33%)                                            
      Fat, Necrosis                                    4 (100%)                  1 (33%)                                            
   Pancreas                                           (59)         (57)         (59)         (60)                                   
      Autolysis                                        1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
      Acinus, Atrophy                                 10 (17%)      6 (11%)      9 (15%)     14 (23%)                               
      Acinus, Atrophy, Focal                           2 (3%)       1 (2%)       2 (3%)       2 (3%)                                
      Artery, Inflammation, Acute                                                1 (2%)                                             
   Pharynx                                                         (1)                       (1)                                    
      Hyperplasia, Basal Cell                                       1 (100%)                                                        
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                                                              2 (3%)                                
      Bulla                                                                                   1 (2%)                                
      Edema                                                                                   1 (2%)                                
      Erosion                                          1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hyperkeratosis                                                2 (3%)                                                          
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Ulcer                                            2 (3%)                                 1 (2%)                                
   Stomach, Glandular                                 (59)         (60)         (60)         (60)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Erosion                                          1 (2%)                                                                       
      Inflammation, Chronic                            2 (3%)       1 (2%)                                                          
      Inflammation, Chronic, Focal                                                            2 (3%)                                
      Mineralization                                                                          1 (2%)                                
      Ulcer                                                         1 (2%)                                                          
      Artery, Inflammation, Chronic                                              1 (2%)                                             
   Tooth                                              (1)                                                                           
      Inflammation, Acute                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  23 (38%)     28 (47%)     27 (45%)     27 (45%)                               
      Mineralization                                                                          2 (3%)                                
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Atrium, Thrombosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (59)         (58)         (60)                                   
      Congestion                                       1 (2%)                    1 (2%)                                             
      Cytoplasmic Alteration                                        1 (2%)                                                          
      Cytoplasmic Alteration, Focal                    1 (2%)       1 (2%)       4 (7%)       4 (7%)                                
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hypertrophy                                                                1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (60)         (59)         (58)         (59)                                   
      Hyperplasia, Focal                               6 (10%)      1 (2%)       2 (3%)       1 (2%)                                
   Islets, Pancreatic                                 (59)         (58)         (59)         (59)                                   
      Ectopic Tissue                                                                          2 (3%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
   Parathyroid Gland                                  (53)         (56)         (59)         (55)                                   
      Hyperplasia                                                                             2 (4%)                                
   Pituitary Gland                                    (58)         (58)         (58)         (60)                                   
      Pars Distalis, Angiectasis                                                 3 (5%)                                             
      Pars Distalis, Cyst                              8 (14%)      8 (14%)      4 (7%)       9 (15%)                               
      Pars Distalis, Hyperplasia, Focal                7 (12%)      4 (7%)       4 (7%)       3 (5%)                                
   Thyroid Gland                                      (59)         (60)         (59)         (60)                                   
      Ultimobranchial Cyst                                          1 (2%)                    1 (2%)                                
      C-Cell, Hyperplasia                              5 (8%)      14 (23%)      5 (8%)       8 (13%)                               
      Follicle, Cyst                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (59)         (60)         (57)                                   
      Abscess                                                       6 (10%)      2 (3%)                                             
      Abscess, Two                                                  1 (2%)       1 (2%)                                             
      Cyst                                            12 (20%)      4 (7%)       3 (5%)       5 (9%)                                
      Cyst, Two                                        1 (2%)                                 1 (2%)                                
      Inflammation, Acute                                           2 (3%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Inflammation, Chronic, Focal                     1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
   Ovary                                              (59)         (60)         (60)         (60)                                   
      Congestion                                                    3 (5%)       1 (2%)       1 (2%)                                
      Cyst                                             3 (5%)       3 (5%)       2 (3%)       5 (8%)                                
      Granuloma                                                                               1 (2%)                                
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Abscess                                                                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Congestion                                       1 (2%)                                                                       
      Cyst                                             2 (3%)                    1 (2%)       1 (2%)                                
      Dilatation                                       3 (5%)                                 1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Prolapse                                                                                1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
      Endometrium, Cyst                                             1 (2%)       1 (2%)       3 (5%)                                
      Endometrium, Necrosis                                                                   1 (2%)                                
   Vagina                                             (2)                                                                           
      Inflammation, Acute                              1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (59)         (60)         (59)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia                                     13 (22%)     11 (19%)      9 (15%)     10 (17%)                               
   Lymph Node                                         (60)         (60)         (60)         (60)                                   
      Mediastinal, Congestion                          2 (3%)       4 (7%)       2 (3%)       6 (10%)                               
      Mediastinal, Pigmentation                                                  1 (2%)       5 (8%)                                
      Mediastinal, Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)                                
      Pancreatic, Congestion                                        2 (3%)                                                          
      Pancreatic, Pigmentation                                                   1 (2%)                                             
      Pancreatic, Lymphatic, Angiectasis               1 (2%)                                                                       
      Renal, Pigmentation, Hemosiderin                 1 (2%)                                                                       
   Lymph Node, Mandibular                             (59)         (58)         (58)         (59)                                   
      Congestion                                       5 (8%)       6 (10%)      3 (5%)       5 (8%)                                
      Infiltration Cellular, Plasma Cell                            1 (2%)       1 (2%)                                             
      Pigmentation                                                               1 (2%)                                             
      Lymphatic, Angiectasis                                        2 (3%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (60)         (59)         (59)         (60)                                   
      Autolysis                                                     1 (2%)                                                          
      Congestion                                       3 (5%)       6 (10%)      1 (2%)       3 (5%)                                
      Depletion Lymphoid                                                                      1 (2%)                                
      Lymphatic, Angiectasis                                                                  3 (5%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Congestion, Focal                                                          1 (2%)                                             
      Fibrosis                                         1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Granuloma                                                     1 (2%)                                                          
      Hematopoietic Cell Proliferation                 5 (8%)       4 (7%)       1 (2%)       1 (2%)                                
      Hemorrhage, Focal                                                          1 (2%)       1 (2%)                                
      Hyperplasia, Histiocytic, Lymphoid               1 (2%)       3 (5%)                                                          
      Infarct                                          1 (2%)       1 (2%)                                                          
      Necrosis, Focal                                  1 (2%)                                                                       
      Pigmentation, Hemosiderin                        8 (13%)      9 (15%)     10 (17%)     12 (20%)                               
      Capsule, Fibrosis                                             1 (2%)                                                          
   Thymus                                             (54)         (55)         (54)         (56)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (52)         (52)         (55)         (59)                                   
      Galactocele                                      7 (13%)      9 (17%)      8 (15%)      5 (8%)                                
      Galactocele, Multiple                                         2 (4%)       1 (2%)                                             
      Lactation                                        5 (10%)      2 (4%)       4 (7%)                                             
   Skin                                               (57)         (60)         (59)         (59)                                   
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperplasia, Basal Cell                                                    1 (2%)                                             
      Pigmentation, Melanin                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Hyperostosis                                     8 (13%)     11 (18%)     10 (17%)     11 (18%)                               
   Skeletal Muscle                                    (1)                       (2)          (1)                                    
      Degeneration                                                               1 (50%)                                            
      Fibrosis                                                                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                      5 (8%)       8 (13%)      4 (7%)       8 (13%)                               
      Hemorrhage, Focal                                1 (2%)                    1 (2%)       1 (2%)                                
      Hydrocephalus                                                              1 (2%)                                             
   Spinal Cord                                        (1)                                    (1)                                    
      Hemorrhage, Focal                                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       4 (7%)       1 (2%)       1 (2%)       3 (5%)                                
      Hemorrhage, Focal                                                          1 (2%)                                             
      Metaplasia, Osseous                                           1 (2%)                                                          
      Alveolar Epithelium, Metaplasia                               1 (2%)       2 (3%)       2 (3%)                                
      Alveolus, Metaplasia                                                       1 (2%)                                             
      Bronchus, Metaplasia, Squamous                                                          1 (2%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Fungus                                           3 (5%)       5 (8%)       3 (5%)       2 (3%)                                
      Inflammation, Acute                              3 (5%)       5 (8%)       4 (7%)       2 (3%)                                
      Inflammation, Chronic                           38 (63%)     41 (68%)     42 (70%)     45 (75%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic, Focal                     4 (7%)       7 (12%)      8 (13%)      6 (10%)                               
      Metaplasia, Squamous                             2 (3%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)          (8)          (4)          (3)                                    
      Cataract                                         1 (17%)      6 (75%)      2 (50%)      1 (33%)                               
      Degeneration                                     1 (17%)                                                                      
      Hemorrhage                                                    1 (13%)                                                         
      Synechia                                         1 (17%)                                                                      
      Cornea, Inflammation, Acute                      1 (17%)                                                                      
      Retina, Degeneration                                          2 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (58)         (60)         (60)                                   
      Autolysis                                                     1 (2%)       2 (3%)                                             
      Cyst                                             1 (2%)                                                                       
      Fibrosis, Focal                                  2 (3%)                    2 (3%)                                             
      Hypertrophy                                      1 (2%)                                                                       
      Mineralization                                                1 (2%)                    3 (5%)                                
      Nephropathy                                     48 (83%)     48 (83%)     53 (88%)     52 (87%)                               
      Pigmentation, Bile                               1 (2%)       1 (2%)                                                          
      Papilla, Fibrosis, Focal                                                   1 (2%)                                             
      Papilla, Necrosis                                                                       1 (2%)                                
      Renal Tubule, Pigmentation                                                              1 (2%)                                
   Urinary Bladder                                    (55)         (57)         (59)         (58)                                   
      Hemorrhage, Focal                                                          1 (2%)                                             
      Inflammation, Focal                                           1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          19           14           18           14                                     
    Dead                                               9            5            3            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           31           29           33                                     
    Dead                                               1                                                                            
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (53)         (55)         (58)         (57)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Parasite Metazoan                                2 (4%)       1 (2%)       2 (3%)       3 (5%)                                
   Intestine Large, Colon                             (55)         (54)         (59)         (58)                                   
      Parasite Metazoan                                5 (9%)       3 (6%)       9 (15%)     12 (21%)                               
   Intestine Large, Rectum                            (54)         (56)         (59)         (58)                                   
      Parasite Metazoan                                9 (17%)      6 (11%)     12 (20%)      8 (14%)                               
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Ileum                             (52)         (55)         (57)         (57)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Liver                                              (59)         (60)         (60)         (60)                                   
      Basophilic Focus                                 3 (5%)       4 (7%)       6 (10%)      4 (7%)                                
      Clear Cell Focus                                 3 (5%)       9 (15%)      8 (13%)      4 (7%)                                
      Clear Cell Focus, Multiple                       1 (2%)                                                                       
      Congestion                                       1 (2%)       1 (2%)                    1 (2%)                                
      Cyst                                                                       1 (2%)                                             
      Cytoplasmic Alteration, Focal                    1 (2%)                                 1 (2%)                                
      Developmental Malformation                       3 (5%)                    1 (2%)       1 (2%)                                
      Fatty Change                                    17 (29%)     14 (23%)     19 (32%)     17 (28%)                               
      Granuloma                                        3 (5%)       4 (7%)       2 (3%)       3 (5%)                                
      Hemorrhage, Focal                                             1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       2 (3%)       4 (7%)       3 (5%)       4 (7%)                                
      Hepatodiaphragmatic Nodule, Two                                                         1 (2%)                                
      Necrosis, Focal                                  1 (2%)                    1 (2%)       3 (5%)                                
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Bile Duct, Hyperplasia                          50 (85%)     55 (92%)     54 (90%)     51 (85%)                               
      Hepatocyte, Hyperplasia, Focal                   2 (3%)       4 (7%)       6 (10%)      3 (5%)                                
      Lymphatic, Angiectasis                                                     1 (2%)                                             
      Serosa, Fibrosis                                 1 (2%)                                                                       
   Mesentery                                          (5)          (6)          (10)         (4)                                    
      Accessory Spleen                                 1 (20%)                   1 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hemorrhage                                                    1 (17%)                                                         
      Mineralization, Focal                                         1 (17%)                                                         
      Fat, Necrosis                                    3 (60%)      5 (83%)      6 (60%)      4 (100%)                              
   Pancreas                                           (55)         (58)         (59)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Cyst                                                                       1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Acinus, Atrophy                                 19 (35%)     16 (28%)     18 (31%)     20 (33%)                               
      Acinus, Atrophy, Focal                           4 (7%)       3 (5%)       3 (5%)       2 (3%)                                
      Artery, Fibrosis                                              1 (2%)                                                          
      Artery, Inflammation, Chronic                                                           3 (5%)                                
   Pharynx                                            (2)                                                                           
      Hyperplasia, Focal                               1 (50%)                                                                      
   Stomach, Forestomach                               (59)         (60)         (60)         (59)                                   
      Acanthosis                                       1 (2%)       2 (3%)                    1 (2%)                                
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperkeratosis, Focal                                         1 (2%)                                                          
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Ulcer                                            4 (7%)       2 (3%)                    2 (3%)                                
   Stomach, Glandular                                 (57)         (58)         (60)         (58)                                   
      Edema                                                                      1 (2%)                                             
      Inflammation, Chronic, Focal                     2 (4%)                                                                       
      Mineralization                                   1 (2%)                                 1 (2%)                                
   Tongue                                             (1)          (1)                                                              
      Hyperkeratosis                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  42 (70%)     45 (75%)     44 (73%)     41 (68%)                               
      Dilatation                                       2 (3%)                                                                       
      Atrium, Dilatation                                                         1 (2%)                                             
      Atrium, Thrombosis                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (60)         (59)         (60)                                   
      Congestion                                       1 (2%)                                                                       
      Congestion, Focal                                                                       1 (2%)                                
      Cytoplasmic Alteration, Focal                    3 (5%)                    5 (8%)       1 (2%)                                
      Hyperplasia, Focal                               1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                 1 (2%)                                
   Adrenal Gland, Medulla                             (58)         (59)         (58)         (59)                                   
      Hyperplasia, Focal                               7 (12%)     11 (19%)      5 (9%)       9 (15%)                               
      Hyperplasia, Focal, Two                          1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (55)         (58)         (58)         (59)                                   
      Hyperplasia                                      4 (7%)       1 (2%)       2 (3%)                                             
   Parathyroid Gland                                  (56)         (56)         (56)         (55)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (58)         (55)         (59)         (56)                                   
      Infarct                                                                    1 (2%)                                             
      Pars Distalis, Angiectasis                                    1 (2%)                    1 (2%)                                
      Pars Distalis, Cyst                              3 (5%)       5 (9%)       4 (7%)       3 (5%)                                
      Pars Distalis, Degeneration, Focal                                         1 (2%)                                             
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                8 (14%)      2 (4%)       9 (15%)      8 (14%)                               
   Thyroid Gland                                      (58)         (58)         (60)         (59)                                   
      Cyst                                             1 (2%)                                                                       
      Cyst Multilocular                                             1 (2%)                                                          
      Ultimobranchial Cyst                                          1 (2%)                                                          
      C-Cell, Hyperplasia                              7 (12%)      4 (7%)       8 (13%)      4 (7%)                                
      Follicle, Cyst                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (58)         (60)         (60)         (60)                                   
      Fibrosis                                                      1 (2%)                                                          
      Spermatocele                                                  1 (2%)                                                          
   Preputial Gland                                    (59)         (59)         (60)         (60)                                   
      Abscess                                                                    2 (3%)       1 (2%)                                
      Congestion                                                                              1 (2%)                                
      Cyst                                             1 (2%)       3 (5%)                    1 (2%)                                
      Inflammation, Acute                                                        1 (2%)       2 (3%)                                
      Inflammation, Acute, Focal                                    2 (3%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                           10 (17%)     11 (19%)     11 (18%)     11 (18%)                               
      Inflammation, Chronic, Focal                     1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Duct, Ectasia                                                                           1 (2%)                                
   Prostate                                           (58)         (60)         (60)         (59)                                   
      Abscess                                          1 (2%)                                                                       
      Atrophy                                                                                 1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Focal                               2 (3%)       6 (10%)      4 (7%)       1 (2%)                                
      Inflammation, Acute                              1 (2%)       1 (2%)       2 (3%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
   Seminal Vesicle                                    (59)         (59)         (59)         (60)                                   
      Atrophy                                         26 (44%)     29 (49%)     27 (46%)     26 (43%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Dilatation                                                                 1 (2%)       1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Acute                              2 (3%)                                                                       
   Testes                                             (59)         (60)         (60)         (60)                                   
      Artery, Inflammation, Chronic                    2 (3%)                                                                       
      Bilateral, Interstitial Cell, Hyperplasia        2 (3%)       2 (3%)       4 (7%)       3 (5%)                                
      Bilateral, Seminiferous Tubule, Atrophy,                                                                                      
           Focal                                                    1 (2%)                                                          
      Interstitial Cell, Hyperplasia                   2 (3%)       2 (3%)                    2 (3%)                                
      Seminiferous Tubule, Atrophy                    10 (17%)      9 (15%)      7 (12%)      8 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (55)         (59)         (60)         (59)                                   
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Hyperplasia                                     11 (20%)      9 (15%)     14 (23%)      8 (14%)                               
      Myelofibrosis                                    1 (2%)                    1 (2%)                                             
   Lymph Node                                         (59)         (57)         (60)         (60)                                   
      Deep Cervical, Lymphatic, Angiectasis                                                   1 (2%)                                
      Mediastinal, Congestion                                       5 (9%)       6 (10%)      1 (2%)                                
      Mediastinal, Lymphatic, Angiectasis                           1 (2%)                    1 (2%)                                
      Pancreatic, Congestion                                        1 (2%)       1 (2%)                                             
      Pancreatic, Hemorrhage                                                                  1 (2%)                                
      Pancreatic, Lymphatic, Angiectasis                                         1 (2%)                                             
   Lymph Node, Mandibular                             (59)         (55)         (59)         (60)                                   
      Angiectasis                                                                             2 (3%)                                
      Congestion                                       4 (7%)       2 (4%)       3 (5%)       5 (8%)                                
      Infarct                                                                    1 (2%)                                             
      Infiltration Cellular, Plasma Cell               2 (3%)       2 (4%)                    2 (3%)                                
      Pigmentation                                                  1 (2%)                                                          
      Lymphatic, Angiectasis                           2 (3%)       2 (4%)       3 (5%)       1 (2%)                                
   Lymph Node, Mesenteric                             (57)         (57)         (60)         (59)                                   
      Congestion                                                                 1 (2%)                                             
      Hyperplasia                                                                             1 (2%)                                
      Lymphatic, Angiectasis                           2 (4%)       3 (5%)       1 (2%)       2 (3%)                                
   Spleen                                             (59)         (58)         (60)         (59)                                   
      Congestion                                                    2 (3%)       1 (2%)       3 (5%)                                
      Cyst                                             1 (2%)                                 1 (2%)                                
      Developmental Malformation                                                 1 (2%)                                             
      Fibrosis                                         9 (15%)      3 (5%)       8 (13%)     13 (22%)                               
      Hematopoietic Cell Proliferation                                           2 (3%)       6 (10%)                               
      Infarct                                          4 (7%)                    1 (2%)       1 (2%)                                
      Necrosis, Focal                                                            1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)       3 (5%)                                
      Capsule, Fibrosis                                                                       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (54)         (54)         (53)         (53)                                   
      Congestion                                                                              1 (2%)                                
      Cyst                                             1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (41)         (52)         (54)                                   
      Galactocele                                      1 (2%)       1 (2%)                    1 (2%)                                
      Lactation                                        2 (4%)       1 (2%)                    4 (7%)                                
   Skin                                               (60)         (60)         (58)         (58)                                   
      Abscess                                                       1 (2%)                    1 (2%)                                
      Acanthosis                                                                 1 (2%)                                             
      Cyst Epithelial Inclusion                        1 (2%)                                 1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hyperkeratosis                                   2 (3%)                                 1 (2%)                                
      Inflammation, Chronic, Granulomatous                          1 (2%)                                                          
      Thrombosis                                       1 (2%)                                                                       
      Ulcer                                            1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fibrosis                                                                                1 (2%)                                
      Hyperostosis                                                               2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                                   2 (3%)       2 (3%)       2 (3%)                                
      Congestion                                                                 1 (2%)                                             
      Hemorrhage, Focal                                5 (8%)       3 (5%)       7 (12%)      3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                    2 (3%)                    3 (5%)                                
      Fungus                                           1 (2%)                                 1 (2%)                                
      Hemorrhage, Focal                                             2 (3%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Adenomatous                                           1 (2%)                                
      Alveolar Epithelium, Metaplasia                  4 (7%)       2 (3%)       2 (3%)       1 (2%)                                
   Nose                                               (60)         (58)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Cyst                                             1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05127-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 18:45:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Fungus                                           9 (15%)      7 (12%)      7 (12%)      4 (7%)                                
      Inflammation, Acute                             12 (20%)     12 (21%)      8 (13%)      7 (12%)                               
      Inflammation, Chronic                           37 (62%)     37 (64%)     41 (68%)     41 (68%)                               
      Inflammation, Chronic, Focal                     8 (13%)     10 (17%)      9 (15%)      8 (13%)                               
      Metaplasia, Squamous                                          1 (2%)       1 (2%)                                             
   Trachea                                            (59)         (58)         (60)         (59)                                   
      Fungus                                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (4)          (5)                                    
      Cataract                                         1 (100%)     1 (100%)     3 (75%)      3 (60%)                               
      Hemorrhage                                                                              1 (20%)                               
      Retina, Degeneration                                                       1 (25%)      3 (60%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)         (57)         (59)         (59)                                   
      Congestion                                                                              3 (5%)                                
      Cyst                                             1 (2%)                    2 (3%)       1 (2%)                                
      Fibrosis                                                                   1 (2%)                                             
      Infarct                                                                    2 (3%)                                             
      Mineralization                                   1 (2%)                    1 (2%)       1 (2%)                                
      Nephropathy                                     53 (93%)     57 (100%)    57 (97%)     56 (95%)                               
      Pigmentation, Bile                                            1 (2%)       1 (2%)                                             
      Artery, Fibrosis                                              1 (2%)                                                          
   Urinary Bladder                                    (52)         (55)         (57)         (58)                                   
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Cyst                                                                                    1 (2%)                                
      Ectasia                                          1 (2%)                                                                       
      Hemorrhage, Focal                                                                       1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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