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TDMS Study 05127-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                     BARIUM CHLORIDE DIHYDRATE


NTP Experiment-Test: 05127-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/16/94
Route: DOSED WATER                                                                                                Time: 19:05:18




       Facility:  TSI Mason Research

       Chemical CAS #:  10326279

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          14           11            9           16                                     
    Dead                                               5            3            2            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           36           39           32                                     
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (57)         (58)         (59)         (60)                                   
   Intestine Large, Colon                             (57)         (57)         (60)         (59)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Intestine Large, Rectum                            (57)         (57)         (60)         (59)                                   
      Schwannoma Malignant                                          1 (2%)                                                          
   Intestine Small, Duodenum                          (57)         (58)         (60)         (60)                                   
      Schwannoma Malignant                                          1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
      Fibrosarcoma, Metastatic                                                   1 (2%)                                             
      Hepatocellular Adenoma                                        1 (2%)                                                          
      Osteosarcoma, Metastatic                                      1 (2%)                                                          
   Mesentery                                          (4)          (1)          (3)                                                 
      Schwannoma Malignant                                          1 (100%)                                                        
   Pancreas                                           (59)         (57)         (59)         (60)                                   
      Schwannoma Malignant                                          1 (2%)                                                          
      Acinus, Adenoma                                  1 (2%)                    1 (2%)                                             
   Salivary Glands                                    (59)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                          1 (2%)                    2 (3%)                                             
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (59)         (58)         (60)                                   
      Adenoma                                          1 (2%)       3 (5%)       1 (2%)                                             
      Osteosarcoma, Metastatic                                      1 (2%)                                                          
   Adrenal Gland, Medulla                             (60)         (59)         (58)         (59)                                   
      Osteosarcoma, Metastatic                                      1 (2%)                                                          
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                          1 (2%)       3 (5%)       2 (3%)       1 (2%)                                
      Pheochromocytoma Benign, Two                     1 (2%)       1 (2%)                                                          
   Islets, Pancreatic                                 (59)         (58)         (59)         (59)                                   
      Adenoma                                                       1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma                                                     2 (3%)                                                          
   Pituitary Gland                                    (58)         (58)         (58)         (60)                                   
      Pars Distalis, Adenoma                          28 (48%)     26 (45%)     28 (48%)     24 (40%)                               
      Pars Distalis, Adenoma, Two                      2 (3%)                    2 (3%)       2 (3%)                                
      Pars Distalis, Carcinoma                         4 (7%)       6 (10%)      4 (7%)       5 (8%)                                
   Thyroid Gland                                      (59)         (60)         (59)         (60)                                   
      C-Cell, Adenoma                                  6 (10%)      8 (13%)      9 (15%)      9 (15%)                               
      C-Cell, Adenoma, Two                                                       1 (2%)       1 (2%)                                
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (59)         (60)         (57)                                   
      Adenoma                                                       1 (2%)                    2 (4%)                                
      Carcinoma                                        1 (2%)       3 (5%)                    1 (2%)                                
      Carcinoma, Two                                   2 (3%)                                                                       
   Ovary                                              (59)         (60)         (60)         (60)                                   
      Granulosa Cell Tumor Benign                                                             1 (2%)                                
      Osteosarcoma, Metastatic                                      1 (2%)                                                          
      Schwannoma Malignant                                          1 (2%)                                                          
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Polyp Stromal                                   14 (23%)      8 (13%)     11 (18%)     13 (22%)                               
      Polyp Stromal, Two                               1 (2%)                                 3 (5%)                                
      Sarcoma Stromal                                               2 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (36)         (37)         (43)         (32)                                   
   Lymph Node                                         (60)         (60)         (60)         (60)                                   
      Mediastinal, Schwannoma Malignant                             1 (2%)                                                          
   Lymph Node, Mandibular                             (59)         (58)         (58)         (59)                                   
      Sarcoma, Metastatic                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (60)         (59)         (59)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic                                      1 (2%)                                                          
      Schwannoma Malignant                                          1 (2%)                                                          
   Thymus                                             (54)         (55)         (54)         (56)                                   
      Thymoma Benign                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (52)         (52)         (55)         (59)                                   
      Adenocarcinoma                                   1 (2%)                    1 (2%)                                             
      Adenoma                                          1 (2%)       2 (4%)                                                          
      Fibroadenoma                                    15 (29%)     15 (29%)     11 (20%)      8 (14%)                               
      Fibroadenoma, Multiple                                        4 (8%)       1 (2%)       3 (5%)                                
      Lipoma                                           1 (2%)                                                                       
      Sarcoma                                                                                 1 (2%)                                
   Skin                                               (57)         (60)         (59)         (59)                                   
      Fibroma                                          4 (7%)       1 (2%)                    1 (2%)                                
      Fibrosarcoma                                     1 (2%)                    1 (2%)                                             
      Keratoacanthoma                                               1 (2%)       1 (2%)                                             
      Lipoma                                                        1 (2%)                    1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)                                 1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (1)                       (2)          (1)                                    
      Lipoma                                           1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Malignant                            1 (2%)                                                                       
      Carcinoma, Metastatic                            3 (5%)       2 (3%)       1 (2%)       2 (3%)                                
      Ependymoma Malignant                                                       1 (2%)                                             
                                                             Page   4                                                               
NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - cont                                                                                                               
      Glioma Malignant                                 1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                    1 (2%)                                
      Carcinoma Adenosquamous                                       1 (2%)                                                          
      Fibrosarcoma, Metastatic                                                   1 (2%)                                             
      Osteosarcoma, Metastatic                                      1 (2%)                                                          
      Sarcoma, Metastatic                                           1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
      Sarcoma, Metastatic                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)          (8)          (4)          (3)                                    
      Sarcoma                                                       1 (13%)                                                         
   Zymbal's Gland                                     (2)                                    (1)                                    
      Carcinoma                                        1 (50%)                                1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (58)         (60)         (60)                                   
   Urinary Bladder                                    (55)         (57)         (59)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            15 (25%)     13 (22%)      9 (15%)      9 (15%)                               
      Lymphoma Malignant Lymphocytic                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            51          44          48          50                                       
     Total Primary Neoplasms                          112         116          91          94                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          39          43          43                                       
     Total Benign Neoplasms                            81          78          73          72                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          27          16          22                                       
     Total Malignant Neoplasms                         31          38          18          22                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4           2           2                                       
     Total Metastatic Neoplasm                          3          11           3           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          19           14           18           14                                     
    Dead                                               9            5            3            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           31           29           33                                     
    Dead                                               1                                                                            
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (53)         (55)         (58)         (57)                                   
      Lipoma                                                        1 (2%)                                                          
   Intestine Large, Colon                             (55)         (54)         (59)         (58)                                   
   Intestine Small, Ileum                             (52)         (55)         (57)         (57)                                   
   Intestine Small, Jejunum                           (53)         (55)         (57)         (57)                                   
   Liver                                              (59)         (60)         (60)         (60)                                   
   Mesentery                                          (5)          (6)          (10)         (4)                                    
      Fibrosarcoma                                                               1 (10%)                                            
   Pancreas                                           (55)         (58)         (59)         (60)                                   
      Acinus, Adenocarcinoma                           1 (2%)                                                                       
      Acinus, Adenoma                                  3 (5%)       4 (7%)       1 (2%)       3 (5%)                                
   Pharynx                                            (2)                                                                           
      Squamous Cell Papilloma                          1 (50%)                                                                      
   Salivary Glands                                    (60)         (58)         (60)         (60)                                   
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
   Stomach, Forestomach                               (59)         (60)         (60)         (59)                                   
      Squamous Cell Papilloma                                       2 (3%)       1 (2%)                                             
   Stomach, Glandular                                 (57)         (58)         (60)         (58)                                   
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Fibroma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (60)         (59)         (60)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
   Adrenal Gland, Medulla                             (58)         (59)         (58)         (59)                                   
      Pheochromocytoma Malignant                       2 (3%)       2 (3%)       2 (3%)                                             
      Pheochromocytoma Benign                         10 (17%)      7 (12%)      9 (16%)      6 (10%)                               
      Pheochromocytoma Benign, Two                     1 (2%)       2 (3%)       2 (3%)                                             
   Islets, Pancreatic                                 (55)         (58)         (58)         (59)                                   
      Adenoma                                          3 (5%)       2 (3%)       5 (9%)       5 (8%)                                
      Carcinoma                                        2 (4%)                    2 (3%)                                             
   Parathyroid Gland                                  (56)         (56)         (56)         (55)                                   
   Pituitary Gland                                    (58)         (55)         (59)         (56)                                   
      Pars Distalis, Adenoma                          23 (40%)     24 (44%)     19 (32%)     23 (41%)                               
      Pars Distalis, Adenoma, Two                                   1 (2%)       1 (2%)                                             
      Pars Distalis, Carcinoma                         1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
   Thyroid Gland                                      (58)         (58)         (60)         (59)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  4 (7%)       5 (9%)       8 (13%)      7 (12%)                               
      C-Cell, Adenoma, Two                                                                    1 (2%)                                
      C-Cell, Carcinoma                                             1 (2%)                    1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                                                 2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (58)         (60)         (60)         (60)                                   
   Preputial Gland                                    (59)         (59)         (60)         (60)                                   
      Adenoma                                          1 (2%)       2 (3%)       2 (3%)                                             
      Carcinoma                                        1 (2%)       1 (2%)                    1 (2%)                                
   Prostate                                           (58)         (60)         (60)         (59)                                   
   Seminal Vesicle                                    (59)         (59)         (59)         (60)                                   
   Testes                                             (59)         (60)         (60)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           28 (47%)     33 (55%)     32 (53%)     24 (40%)                               
      Interstitial Cell, Adenoma                      15 (25%)     15 (25%)     18 (30%)     20 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (26)         (39)         (39)         (9)                                    
   Bone Marrow                                        (55)         (59)         (60)         (59)                                   
   Lymph Node                                         (59)         (57)         (60)         (60)                                   
   Lymph Node, Mandibular                             (59)         (55)         (59)         (60)                                   
   Lymph Node, Mesenteric                             (57)         (57)         (60)         (59)                                   
   Spleen                                             (59)         (58)         (60)         (59)                                   
      Sarcoma                                          1 (2%)                                                                       
   Thymus                                             (54)         (54)         (53)         (53)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (41)         (52)         (54)                                   
      Fibroadenoma                                     2 (4%)       3 (7%)       1 (2%)                                             
   Skin                                               (60)         (60)         (58)         (58)                                   
      Basal Cell Carcinoma                             1 (2%)                                 2 (3%)                                
      Fibroma                                                                    1 (2%)       1 (2%)                                
      Fibrosarcoma                                     1 (2%)                    1 (2%)       1 (2%)                                
      Hemangioma                                                    1 (2%)                    1 (2%)                                
      Keratoacanthoma                                  1 (2%)       3 (5%)                                                          
      Lipoma                                           1 (2%)                    1 (2%)                                             
      Trichoepithelioma                                1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                                              (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Malignant                                                                   1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
   Peripheral Nerve                                                (2)          (1)          (1)                                    
      Schwannoma Benign                                             1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic                                                      1 (2%)                                             
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
   Nose                                               (60)         (58)         (60)         (60)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Adenoma                                                       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (2)          (1)          (2)                                    
      Carcinoma                                                     2 (100%)     1 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)         (57)         (59)         (59)                                   
   Urinary Bladder                                    (52)         (55)         (57)         (58)                                   
      Leiomyoma, Two                                   1 (2%)                                                                       
      Transitional Epithelium, Papilloma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            35 (58%)     25 (42%)     26 (43%)     15 (25%)                               
      Lymphoma Malignant Lymphocytic                                1 (2%)                                                          
      Mesothelioma Benign                              1 (2%)                                                                       
      Mesothelioma Malignant                                                     1 (2%)                                             
      Mesothelioma NOS                                 1 (2%)                    1 (2%)       1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05127-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                     BARIUM CHLORIDE DIHYDRATE                                 Date: 09/16/94  
Route: DOSED WATER                                                                                                Time: 19:05:18  
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         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            56          57          59          57                                       
     Total Primary Neoplasms                          146         142         141         120                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 52          57          56          52                                       
     Total Benign Neoplasms                           100         109         102          93                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          27          35          25                                       
     Total Malignant Neoplasms                         45          33          38          26                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      2           1                                       
     Total Metastatic Neoplasm                                                  3           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       1           1                                       
     Total Uncertain Neoplasms                          2                       1           2                                       
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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