National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2206

TDMS Study 05127-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/16/94   
EXP: 05127                BARIUM CHLORIDE DIHYDRATE            TIME: 19:15:13   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED WATER                 NTP C#: C61074   
CONT: N01ES55115                                               CAS: 10326279    
PATHOLOGIST: A. RUSSFIELD                    S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/16/94  
EXP: 05127                BARIUM CHLORIDE DIHYDRATE            TIME: 19:15:13  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED WATER                 NTP C#: C61074  
CONT: N01ES55115                                               CAS: 10326279   
PATHOLOGIST: A. RUSSFIELD                    S. EUSTIS                         

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 28     CENSORED DEATHS 10   TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      305   482   543   543   565   578   605   612   655   671                 |
 |      673   673   681   681   684   687   691   701   701   703                 |
 |      708   708   708   708   712   722   722   723                             |
 |  CENSORED DEATHS                                                               |
 |      452   452   452   452   453   453   453   453   453   453                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 19     CENSORED DEATHS 10   TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      520   537   544   562   565   565   565   580   615   653                 |
 |      658   661   669   670   673   687   708   723   724                       |
 |  CENSORED DEATHS                                                               |
 |      452   452   452   452   452   452   453   453   453   453                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1250 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 10   TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      506   520   528   543   590   591   621   636   655   661                 |
 |      667   683   688   704   708   709   709   711   717   719                 |
 |      723                                                                       |
 |  CENSORED DEATHS                                                               |
 |      452   452   452   452   453   453   453   453   453   453                 |
 |                                                                                |
 ==================================================================================

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 2500 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 10   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      312   397   520   559   564   564   582   601   615   620                 |
 |      633   659   669   674   675   681   726                                   |
 |  CENSORED DEATHS                                                               |
 |      452   452   452   452   452   452   453   453   453   453                 |
 |                                                                                |
 ==================================================================================

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   730 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0  98.3  98.3  96.3  92.3  86.3  82.3  44.1      |
 |           |                                                                    |
 |           |                                                                    |
 |500 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  84.0  76.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1250 PPM   |   100.0 100.0 100.0 100.0 100.0 100.0  92.0  88.0  80.0  58.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2500 PPM   |   100.0 100.0 100.0  98.3  96.7  96.7  94.7  84.6  76.5  66.5      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        500 PPM      1250 PPM     2500 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       44.1%        62.0%        58.0%        66.5%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.153N     P=0.193N     P=0.236N     P=0.111N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       648.0        625.2        647.1        591.2    |
 |NATURAL DEATHS (C)      |       (17.6)       (15.5)       (15.9)       (25.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       645.5        650.6        654.8        644.4    |
 |(STANDARD ERROR)        |       (14.7)       (13.9)       (13.9)       (15.4)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 19     CENSORED DEATHS 10   TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      359   380   462   526   575   575   589   591   606   625                 |
 |      634   645   652   653   658   687   687   692   698                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 14     CENSORED DEATHS 10   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      428   457   477   647   666   689   695   706   706   706                 |
 |      707   707   713   713                                                     |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   458   458   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1250 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 10   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      310   430   462   483   520   541   627   643   643   668                 |
 |      673                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   458   458   458   458   458                 |
 |                                                                                |
 ==================================================================================

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 2500 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 10   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      493   510   527   563   617   621   644   647   650   669                 |
 |      669   679   692   699   707   707   730   730                             |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   458   458   458                 |
 |                                                                                |
 ==================================================================================

                             BARIUM CHLORIDE DIHYDRATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   737 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0  98.3  96.7  94.7  92.6  84.6  70.5  62.4      |
 |           |                                                                    |
 |           |                                                                    |
 |500 PPM    |   100.0 100.0 100.0 100.0 100.0  94.6  94.6  94.6  92.6  72.4      |
 |           |                                                                    |
 |           |                                                                    |
 |1250 PPM   |   100.0 100.0 100.0  98.3  98.3  92.6  88.6  88.6  82.6  78.5      |
 |           |                                                                    |
 |           |                                                                    |
 |2500 PPM   |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  92.0  82.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        500 PPM      1250 PPM     2500 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       62.4%        72.4%        78.5%        64.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.969N     P=0.231N     P=0.155N     P=0.789N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       594.4        644.1        545.5        641.9    |
 |NATURAL DEATHS (C)      |       (22.8)       (28.1)       (35.3)       (17.4)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       645.2        668.7        655.2        661.7    |
 |(STANDARD ERROR)        |       (15.4)       (14.7)       (16.2)       (14.1)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                     BARIUM CHLORIDE DIHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        500 PPM          = 2
                                                        1250 PPM         = 3
                                                        2500 PPM         = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                               1 4                             3  2
      |                                                 1 4            4            1   3  2 21
      |                                                                                    3322 42
      |                                                                                       1 41    3
P  90 +                                                                                          1 1
E     |                                                                                          4 14 34113
R     |                                                                                          2 2   4 13 3  1
C     |                                                                                                  24    1 31
E  80 +                                                                                                   4 4    311
N     |                                                                                                     4  2 2311
T     |                                                                                                          22433 3
      |                                                                                                           22   33
S  70 +                                                                                                            211
U     |                                                                                                             42  2 4 4
R     |                                                                                                              1 1232
V     |                                                                                                                   2 2
I  60 +                                                                                                                1133
V     |                                                                                                                   3 3
A     |
L     |
   50 +                                                                                                                 1 1
      |
      |                                                                                                                   1 1
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 35 obs hidden.

                                                     BARIUM CHLORIDE DIHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        500 PPM          = 2
                                                        1250 PPM         = 3
                                                        2500 PPM         = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                 3      1          2         4
      |                                                   3      1   1      2    2
      |                                                                               4 4
      |                                                              1      3    1  2   4   4
   95 +                                                                          1  2       1                 2
      |                                                                                     4    4
      |                                                                             3      31    4 1      4   2   2
      |                                                                                    3  3
P  90 +                                                                                                           2  2
E     |                                                                                       3    1  1    3         22
R     |                                                                                                   4  4
C     |                                                                                                    3 34       22
E  85 +                                                                                               1 1
N     |
T     |                                                                                                 1  1 34   3
      |
S  80 +                                                                                                    11     33
U     |                                                                                                     1 1    3         3
R     |                                                                                                           44
V     |                                                                                                       11   4 4 22
I  75 +
V     |                                                                                                              44
A     |                                                                                                               442    2
L     |
   70 +                                                                                                        1     1
      |
      |                                                                                                                4    4
      |
   65 +                                                                                                              11
      |                                                                                                                     44
      |                                                                                                               1      1
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 10 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.