National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2208

TDMS Study 05128-06 Pathology Tables

NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96
Route: DOSED FEED                                                                                                 Time: 23:34:28




       Facility:  Southern Research Institute

       Chemical CAS #:  8003-22-3

       Lock Date:  01/12/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10            9           10            9                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           23           12           25                                     
    Natural Death                                      3            2            1            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           26           37           23                                     

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (58)         (59)         (60)                                   
      Parasite Metazoan                                5 (8%)                    4 (7%)       3 (5%)                                
   Intestine Large, Rectum                            (59)         (59)         (59)         (59)                                   
      Edema                                                                                   1 (2%)                                
      Parasite Metazoan                                5 (8%)       4 (7%)       6 (10%)      3 (5%)                                
   Intestine Large, Cecum                             (60)         (60)         (59)         (59)                                   
      Edema                                            1 (2%)       1 (2%)       2 (3%)                                             
      Parasite Metazoan                                1 (2%)                                                                       
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Duodenum                          (60)         (60)         (60)         (59)                                   
      Ulcer                                                         1 (2%)                                                          
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Intestine Small, Jejunum                           (59)         (60)         (60)         (60)                                   
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Intestine Small, Ileum                             (58)         (60)         (59)         (58)                                   
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)       2 (3%)       3 (5%)       1 (2%)                                
      Basophilic Focus                                39 (65%)     28 (47%)     13 (22%)     13 (22%)                               
      Clear Cell Focus                                10 (17%)     19 (32%)     33 (55%)     34 (57%)                               
      Cyst                                                          3 (5%)       4 (7%)                                             
      Cytoplasmic Alteration                           2 (3%)                                                                       
      Degeneration, Cystic                                                                    1 (2%)                                
      Eosinophilic Focus                              10 (17%)      9 (15%)     15 (25%)     16 (27%)                               
      Granuloma                                       10 (17%)      1 (2%)       2 (3%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)       2 (3%)       7 (12%)                               
      Hepatodiaphragmatic Nodule                       7 (12%)      5 (8%)       7 (12%)      5 (8%)                                
      Inflammation, Subacute                           5 (8%)       5 (8%)      10 (17%)     12 (20%)                               
      Mixed Cell Focus                                12 (20%)     19 (32%)     20 (33%)     16 (27%)                               
      Necrosis, Focal                                  2 (3%)       2 (3%)       5 (8%)       4 (7%)                                
      Thrombosis                                                    1 (2%)       2 (3%)       2 (3%)                                
      Bile Duct, Hyperplasia                          15 (25%)     11 (18%)     33 (55%)     42 (70%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Pigmentation                                      55 (92%)     56 (93%)     59 (98%)                               
      Centrilobular, Atrophy                           4 (7%)       9 (15%)      5 (8%)       5 (8%)                                
      Centrilobular, Necrosis                          1 (2%)                                 1 (2%)                                
      Hepatocyte, Cytologic Alterations                            15 (25%)     41 (68%)     49 (82%)                               
      Hepatocyte, Pigmentation                                     43 (72%)     54 (90%)     59 (98%)                               
      Hepatocyte, Vacuolization Cytoplasmic            6 (10%)      6 (10%)      2 (3%)       4 (7%)                                
      Kupffer Cell, Pigmentation                       9 (15%)     11 (18%)     16 (27%)     41 (68%)                               
   Mesentery                                          (12)         (20)         (8)          (14)                                   
      Accessory Spleen                                 1 (8%)                                 2 (14%)                               
      Angiectasis                                      1 (8%)                                                                       
      Fat, Necrosis                                    9 (75%)     18 (90%)      8 (100%)    11 (79%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Atrophy                                         11 (18%)     19 (32%)     20 (33%)     15 (25%)                               
      Necrosis                                                                   1 (2%)                                             
      Acinar Cell, Cytoplasmic Alteration              3 (5%)       2 (3%)                    2 (3%)                                
      Acinar Cell, Hyperplasia, Focal                  1 (2%)       1 (2%)                    1 (2%)                                
   Salivary Glands                                    (60)         (55)         (60)         (59)                                   
      Atrophy                                                       8 (15%)      8 (13%)     15 (25%)                               
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                            5 (8%)                    2 (3%)       4 (7%)                                
      Fibrosis                                         1 (2%)                                                                       
      Ulcer                                            4 (7%)       1 (2%)                    3 (5%)                                
      Mucosa, Hyperplasia                              5 (8%)      17 (28%)     31 (52%)     27 (45%)                               
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Edema                                                         2 (3%)       2 (3%)       2 (3%)                                
      Erosion                                          2 (3%)       1 (2%)                    2 (3%)                                
      Mineralization                                                                          2 (3%)                                
      Ulcer                                            1 (2%)       2 (3%)                                                          
   Tooth                                              (1)                                                                           
      Developmental Malformation                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (60)                                   
      Hypertrophy                                                                1 (2%)                                             
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  17 (28%)     18 (30%)     18 (30%)     12 (20%)                               
      Mineralization                                                                          1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                5 (8%)      17 (28%)     13 (22%)     14 (23%)                               
      Angiectasis                                                   2 (3%)       2 (3%)                                             
      Degeneration, Fatty                              9 (15%)     10 (17%)      9 (15%)      5 (8%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                    1 (2%)                                
      Hyperplasia, Diffuse                                                       1 (2%)       1 (2%)                                
      Hyperplasia, Focal                               3 (5%)       2 (3%)       2 (3%)       1 (2%)                                
      Hypertrophy                                      2 (3%)                                                                       
      Hypertrophy, Focal                               3 (5%)       2 (3%)       3 (5%)                                             
      Necrosis                                                      1 (2%)                    1 (2%)                                
   Adrenal Medulla                                    (58)         (60)         (59)         (59)                                   
      Hyperplasia                                      3 (5%)       1 (2%)       4 (7%)                                             
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (58)         (57)         (57)         (59)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Pars Distalis, Angiectasis                      11 (18%)      6 (10%)     17 (28%)     13 (22%)                               
      Pars Distalis, Cyst                             29 (48%)     28 (47%)     34 (57%)     26 (43%)                               
      Pars Distalis, Hyperplasia, Focal               10 (17%)      6 (10%)     10 (17%)      9 (15%)                               
      Pars Intermedia, Angiectasis                     3 (5%)       1 (2%)       1 (2%)                                             
      Pars Intermedia, Cyst                            1 (2%)                    2 (3%)       2 (3%)                                
      Pars Intermedia, Hyperplasia                     2 (3%)                                                                       
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Ultimobranchial Cyst                             3 (5%)       7 (12%)      5 (8%)       5 (8%)                                
      C-Cell, Hyperplasia                             13 (22%)      7 (12%)     10 (17%)      9 (15%)                               
      Follicle, Cyst                                                             4 (7%)       4 (7%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (59)         (59)         (60)                                   
      Cyst                                             2 (3%)       4 (7%)       3 (5%)       1 (2%)                                
      Hyperplasia                                      3 (5%)       1 (2%)       2 (3%)       1 (2%)                                
      Inflammation, Chronic                                                                   2 (3%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Suppurative                        2 (3%)       1 (2%)                                                          
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Cyst                                            14 (23%)     17 (28%)     17 (28%)     19 (32%)                               
   Uterus                                             (60)         (60)         (60)         (60)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hydrometra                                       2 (3%)       9 (15%)      4 (7%)      10 (17%)                               
      Hyperplasia, Cystic                              5 (8%)       1 (2%)       4 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      4 (7%)       1 (2%)       3 (5%)       5 (8%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Myelofibrosis                                    3 (5%)       2 (3%)       3 (5%)       3 (5%)                                
      Necrosis                                         1 (2%)                                                                       
   Lymph Node                                         (10)         (13)         (13)         (17)                                   
      Deep Cervical, Pigmentation                                   1 (8%)                                                          
      Iliac, Pigmentation                                                                     1 (6%)                                
      Inguinal, Hyperplasia, Lymphoid                  1 (10%)                                                                      
      Mediastinal, Hemorrhage                          2 (20%)      4 (31%)      5 (38%)      4 (24%)                               
      Mediastinal, Hyperplasia, Lymphoid                            2 (15%)      1 (8%)       1 (6%)                                
      Mediastinal, Pigmentation                        6 (60%)      9 (69%)      8 (62%)     10 (59%)                               
      Pancreatic, Granuloma                                                                   1 (6%)                                
      Pancreatic, Hemorrhage                           1 (10%)                                2 (12%)                               
      Pancreatic, Hyperplasia, Lymphoid                1 (10%)                   1 (8%)       2 (12%)                               
      Pancreatic, Pigmentation                         1 (10%)      2 (15%)      6 (46%)      8 (47%)                               
      Renal, Hemorrhage                                             1 (8%)                    1 (6%)                                
      Renal, Hyperplasia, Lymphoid                                                            1 (6%)                                
      Renal, Pigmentation                                           1 (8%)                    1 (6%)                                
   Lymph Node, Mandibular                             (60)         (60)         (60)         (58)                                   
      Ectasia                                          1 (2%)       3 (5%)       7 (12%)      5 (9%)                                
      Hemorrhage                                      13 (22%)     11 (18%)     17 (28%)      7 (12%)                               
      Hyperplasia, Lymphoid                            5 (8%)      10 (17%)     14 (23%)     13 (22%)                               
      Pigmentation                                    24 (40%)     28 (47%)     21 (35%)     21 (36%)                               
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
      Hemorrhage                                       5 (8%)       1 (2%)       1 (2%)       2 (3%)                                
      Hyperplasia, Lymphoid                            2 (3%)       5 (8%)       5 (8%)       2 (3%)                                
      Pigmentation                                                  1 (2%)                    1 (2%)                                
   Spleen                                             (60)         (59)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Developmental Malformation                                                              1 (2%)                                
      Fibrosis                                                      3 (5%)       5 (8%)       4 (7%)                                
      Hematopoietic Cell Proliferation                28 (47%)     23 (39%)     30 (50%)     32 (53%)                               
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Metaplasia, Osseous                                           1 (2%)                                                          
      Necrosis                                         1 (2%)                    1 (2%)       1 (2%)                                
      Pigmentation                                    37 (62%)     37 (63%)     32 (53%)     38 (63%)                               
      Lymphoid Follicle, Atrophy                                                 2 (3%)                                             
   Thymus                                             (60)         (58)         (59)         (58)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                                                             1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Hyperplasia                                     47 (78%)     42 (70%)     37 (62%)     42 (70%)                               
   Skin                                               (59)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Edema                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Arthrosis                                                                               1 (2%)                                
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Hyperostosis                                                  1 (2%)                                                          
      Cranium, Osteopetrosis                           6 (10%)      7 (12%)      3 (5%)       3 (5%)                                
      Femur, Osteopetrosis                             5 (8%)       7 (12%)      1 (2%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Developmental Malformation                       9 (15%)     11 (18%)      8 (13%)     14 (23%)                               
      Gliosis                                                                                 1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hydrocephalus                                    2 (3%)                                 4 (7%)                                
   Peripheral Nerve                                   (2)          (2)                       (2)                                    
      Degeneration                                                  1 (50%)                                                         
      Inflammation, Chronic                                         1 (50%)                                                         
   Spinal Cord                                        (3)          (2)                       (2)                                    
      Necrosis                                         1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Edema                                                                                   1 (2%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)       6 (10%)                               
      Infiltration Cellular, Histiocyte               38 (63%)     34 (57%)     37 (62%)     43 (72%)                               
      Inflammation, Subacute                                        6 (10%)      1 (2%)       4 (7%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       2 (3%)       3 (5%)       6 (10%)                               
   Nose                                               (60)         (60)         (60)         (60)                                   
      Exudate                                          5 (8%)       5 (8%)       3 (5%)       2 (3%)                                
      Foreign Body                                     2 (3%)       1 (2%)       2 (3%)                                             
      Mucosa, Hyperplasia                              4 (7%)       2 (3%)       2 (3%)                                             
      Mucosa, Metaplasia, Squamous                     3 (5%)       2 (3%)       2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (1)                                                 
      Atrophy                                          1 (100%)                                                                     
      Cataract                                                      2 (100%)     1 (100%)                                           
      Hemorrhage                                                                 1 (100%)                                           
      Retina, Degeneration                                          2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mineralization                                  58 (97%)     58 (97%)     54 (90%)     42 (70%)                               
      Nephropathy                                     51 (85%)     53 (88%)     53 (88%)     59 (98%)                               
      Renal Tubule, Cytoplasmic Alteration             1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Renal Tubule, Necrosis                           1 (2%)                                 1 (2%)                                
      Renal Tubule, Pigmentation                      10 (17%)     57 (95%)     60 (100%)    60 (100%)                              
      Transitional Epithelium, Hyperplasia             2 (3%)       6 (10%)     10 (17%)      5 (8%)                                
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                                                             1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10            9            9            6                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                29           29           41           49                                     
    Natural Death                                      2            2            1            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           20            8            2                                     
  Other                                                                          1                                                  

  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)         (59)         (58)         (59)                                   
      Edema                                                                      1 (2%)       1 (2%)                                
      Parasite Metazoan                                5 (8%)       4 (7%)       9 (16%)      3 (5%)                                
   Intestine Large, Rectum                            (60)         (58)         (60)         (60)                                   
      Parasite Metazoan                               10 (17%)      1 (2%)       5 (8%)       8 (13%)                               
   Intestine Large, Cecum                             (60)         (59)         (59)         (60)                                   
      Edema                                            1 (2%)       4 (7%)       8 (14%)     12 (20%)                               
      Parasite Metazoan                                2 (3%)       2 (3%)       2 (3%)       3 (5%)                                
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)                                   
      Erosion                                                                    1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)       4 (7%)      22 (37%)     21 (35%)                               
   Intestine Small, Jejunum                           (60)         (59)         (60)         (60)                                   
      Cyst                                                                                    1 (2%)                                
      Inflammation, Chronic                                                                   2 (3%)                                
      Ulcer                                                                                   1 (2%)                                
      Epithelium, Hyperplasia                                       3 (5%)      10 (17%)     12 (20%)                               
   Intestine Small, Ileum                             (59)         (59)         (59)         (60)                                   
      Epithelium, Hyperplasia                                       3 (5%)      10 (17%)      8 (13%)                               
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      6 (10%)      6 (10%)     11 (18%)     12 (20%)                               
      Basophilic Focus                                15 (25%)      9 (15%)      6 (10%)      8 (13%)                               
      Clear Cell Focus                                 9 (15%)     15 (25%)     16 (27%)     19 (32%)                               
      Congestion                                                                              3 (5%)                                
      Cyst                                                                       2 (3%)                                             
      Degeneration, Cystic                            15 (25%)     19 (32%)     10 (17%)     13 (22%)                               
      Developmental Malformation                                                 2 (3%)                                             
      Eosinophilic Focus                               7 (12%)      7 (12%)     14 (23%)     12 (20%)                               
      Granuloma                                        3 (5%)       2 (3%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                                           5 (8%)       1 (2%)                                
      Hepatodiaphragmatic Nodule                       2 (3%)       2 (3%)                    3 (5%)                                
      Inflammation, Subacute                           1 (2%)       2 (3%)      11 (18%)      5 (8%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mixed Cell Focus                                 1 (2%)      10 (17%)      9 (15%)     11 (18%)                               
      Necrosis, Focal                                  2 (3%)      11 (18%)      3 (5%)       3 (5%)                                
      Thrombosis                                       2 (3%)       4 (7%)       1 (2%)       6 (10%)                               
      Bile Duct, Hyperplasia                          53 (88%)     26 (43%)     18 (30%)     33 (55%)                               
      Bile Duct, Pigmentation                                      47 (78%)     60 (100%)    60 (100%)                              
      Centrilobular, Atrophy                          14 (23%)     17 (28%)      8 (13%)     15 (25%)                               
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Hepatocyte, Cytologic Alterations                            28 (47%)     53 (88%)     48 (80%)                               
      Hepatocyte, Pigmentation                                     23 (38%)     53 (88%)     57 (95%)                               
      Hepatocyte, Vacuolization Cytoplasmic            5 (8%)                    1 (2%)       2 (3%)                                
      Kupffer Cell, Pigmentation                       7 (12%)     15 (25%)     23 (38%)     31 (52%)                               
   Mesentery                                          (12)         (12)         (10)         (13)                                   
      Accessory Spleen                                                                        1 (8%)                                
      Angiectasis                                                   1 (8%)                    1 (8%)                                
      Cyst                                                                                    1 (8%)                                
      Fat, Necrosis                                   12 (100%)    12 (100%)    10 (100%)    12 (92%)                               
   Oral Mucosa                                                     (2)          (3)          (4)                                    
      Hyperplasia                                                                             1 (25%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Atrophy                                         26 (43%)     32 (53%)     27 (45%)     24 (40%)                               
      Basophilic Focus                                 1 (2%)       3 (5%)       2 (3%)       1 (2%)                                
      Edema                                            3 (5%)      10 (17%)     16 (27%)     22 (37%)                               
      Inflammation, Chronic                                                      1 (2%)                                             
      Metaplasia                                       1 (2%)                                 1 (2%)                                
      Thrombosis                                                                              2 (3%)                                
      Acinar Cell, Cytoplasmic Alteration                           5 (8%)      11 (18%)      8 (13%)                               
      Acinar Cell, Hyperplasia, Focal                  6 (10%)      3 (5%)       6 (10%)      9 (15%)                               
   Salivary Glands                                    (60)         (60)         (59)         (60)                                   
      Atrophy                                          1 (2%)       1 (2%)       5 (8%)       7 (12%)                               
      Basophilic Focus                                                           1 (2%)                                             
      Edema                                                         1 (2%)       6 (10%)     21 (35%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                            5 (8%)      10 (17%)     15 (25%)     13 (22%)                               
      Perforation                                                                             1 (2%)                                
      Ulcer                                            5 (8%)       3 (5%)       5 (8%)       5 (8%)                                
      Mucosa, Hyperplasia                              4 (7%)      13 (22%)     19 (32%)     21 (35%)                               
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Edema                                            7 (12%)      2 (3%)       7 (12%)      8 (13%)                               
      Erosion                                          2 (3%)                    1 (2%)       1 (2%)                                
      Ulcer                                            1 (2%)                                                                       
   Tongue                                             (1)          (1)          (1)          (4)                                    
      Hyperplasia                                                                             1 (25%)                               
      Epithelium, Hyperplasia                                                                 1 (25%)                               
   Tooth                                                           (1)          (3)                                                 
      Necrosis                                                      1 (100%)     2 (67%)                                            
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (59)                                   
      Hypertrophy                                      1 (2%)       3 (5%)                    3 (5%)                                
      Inflammation, Subacute                           1 (2%)       2 (3%)                    3 (5%)                                
      Mineralization                                                                          1 (2%)                                
      Necrosis                                                                                1 (2%)                                
      Thrombosis                                                    3 (5%)       2 (3%)       3 (5%)                                
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  44 (73%)     35 (58%)     35 (58%)     30 (50%)                               
      Mineralization                                                                          2 (3%)                                
      Thrombosis                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule               10 (17%)     21 (35%)     13 (22%)     14 (23%)                               
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Degeneration, Fatty                             11 (18%)      5 (8%)       7 (12%)      6 (10%)                               
      Hyperplasia, Diffuse                                                                    2 (3%)                                
      Hyperplasia, Focal                                            1 (2%)       2 (3%)       2 (3%)                                
      Hypertrophy, Focal                               5 (8%)       2 (3%)       2 (3%)       1 (2%)                                
      Necrosis                                         1 (2%)       1 (2%)                                                          
   Adrenal Medulla                                    (60)         (59)         (60)         (60)                                   
      Hyperplasia                                     13 (22%)     20 (34%)     18 (30%)     19 (32%)                               
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (57)         (55)         (57)         (58)                                   
      Cyst                                                                       1 (2%)                                             
      Hyperplasia                                      3 (5%)       9 (16%)     15 (26%)     17 (29%)                               
   Pituitary Gland                                    (60)         (59)         (58)         (58)                                   
      Pars Distalis, Angiectasis                       7 (12%)      2 (3%)       6 (10%)      3 (5%)                                
      Pars Distalis, Cyst                              4 (7%)       6 (10%)      5 (9%)       7 (12%)                               
      Pars Distalis, Hyperplasia, Focal               12 (20%)      7 (12%)      6 (10%)     10 (17%)                               
      Pars Intermedia, Angiectasis                     1 (2%)       1 (2%)       1 (2%)                                             
      Pars Intermedia, Cyst                                         2 (3%)       3 (5%)       3 (5%)                                
      Pars Nervosa, Developmental Malformation                                   1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (59)         (60)                                   
      Ultimobranchial Cyst                             2 (3%)       4 (7%)       2 (3%)       4 (7%)                                
      C-Cell, Hyperplasia                              2 (3%)       6 (10%)      1 (2%)       6 (10%)                               
      Follicle, Cyst                                   1 (2%)       2 (3%)       6 (10%)      7 (12%)                               
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (59)         (60)         (60)         (60)                                   
      Atypia Cellular                                 19 (32%)     28 (47%)     27 (45%)     23 (38%)                               
      Edema                                            1 (2%)       3 (5%)       5 (8%)      14 (23%)                               
      Granuloma Sperm                                                            1 (2%)       1 (2%)                                
      Hypospermia                                     26 (44%)     37 (62%)     38 (63%)     29 (48%)                               
   Preputial Gland                                    (59)         (59)         (60)         (60)                                   
      Cyst                                             3 (5%)       4 (7%)       1 (2%)                                             
      Hyperplasia                                      2 (3%)                    1 (2%)       2 (3%)                                
      Inflammation, Chronic                           15 (25%)      9 (15%)     12 (20%)      6 (10%)                               
      Inflammation, Suppurative                        8 (14%)      5 (8%)       7 (12%)      1 (2%)                                
   Prostate                                           (60)         (60)         (60)         (59)                                   
      Corpora Amylacea                                18 (30%)     29 (48%)     25 (42%)     18 (31%)                               
      Edema                                            1 (2%)       2 (3%)       2 (3%)      12 (20%)                               
      Inflammation, Suppurative                       37 (62%)     29 (48%)     36 (60%)     38 (64%)                               
      Epithelium, Hyperplasia                          6 (10%)      5 (8%)       3 (5%)       1 (2%)                                
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
      Edema                                                         1 (2%)                    1 (2%)                                
   Testes                                             (59)         (60)         (60)         (60)                                   
      Interstitial Cell, Hyperplasia                  13 (22%)      8 (13%)      7 (12%)      6 (10%)                               
      Seminiferous Tubule, Atrophy                     4 (7%)       4 (7%)       2 (3%)       6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                                 5 (8%)       3 (5%)                                
      Hyperplasia                                      3 (5%)       1 (2%)       4 (7%)       4 (7%)                                
      Myelofibrosis                                    3 (5%)       3 (5%)       1 (2%)       4 (7%)                                
   Lymph Node                                         (22)         (25)         (30)         (47)                                   
      Hemorrhage                                                                 2 (7%)       4 (9%)                                
      Hyperplasia, Lymphoid                                                      2 (7%)       4 (9%)                                
      Pigmentation                                                               1 (3%)       2 (4%)                                
      Axillary, Ectasia                                                          1 (3%)                                             
      Axillary, Hemorrhage                                                       1 (3%)                                             
      Axillary, Hyperplasia, Lymphoid                                            1 (3%)                                             
      Axillary, Pigmentation                                                     1 (3%)                                             
      Deep Cervical, Hemorrhage                                                  2 (7%)                                             
      Deep Cervical, Hyperplasia, Lymphoid                                       1 (3%)                                             
      Deep Cervical, Pigmentation                      2 (9%)                    4 (13%)      1 (2%)                                
      Iliac, Ectasia                                   1 (5%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Iliac, Hemorrhage                                                                       1 (2%)                                
      Iliac, Hyperplasia, Lymphoid                                                            1 (2%)                                
      Iliac, Pigmentation                                                        1 (3%)       1 (2%)                                
      Inguinal, Hemorrhage                                                       2 (7%)       2 (4%)                                
      Inguinal, Hyperplasia, Lymphoid                                            2 (7%)       2 (4%)                                
      Mediastinal, Ectasia                                                       3 (10%)      1 (2%)                                
      Mediastinal, Hemorrhage                          2 (9%)       5 (20%)      9 (30%)     17 (36%)                               
      Mediastinal, Hyperplasia, Lymphoid                                        11 (37%)     17 (36%)                               
      Mediastinal, Pigmentation                       10 (45%)     11 (44%)     15 (50%)     23 (49%)                               
      Pancreatic, Ectasia                              2 (9%)                                                                       
      Pancreatic, Hemorrhage                                        1 (4%)       1 (3%)                                             
      Pancreatic, Hyperplasia, Lymphoid                                          1 (3%)       6 (13%)                               
      Pancreatic, Pigmentation                         1 (5%)       3 (12%)      3 (10%)     12 (26%)                               
      Renal, Ectasia                                                                          1 (2%)                                
      Renal, Hemorrhage                                                          1 (3%)       2 (4%)                                
      Renal, Hyperplasia, Lymphoid                                               1 (3%)       4 (9%)                                
      Renal, Pigmentation                              3 (14%)                   1 (3%)      11 (23%)                               
   Lymph Node, Mandibular                             (60)         (59)         (59)         (59)                                   
      Ectasia                                          7 (12%)      8 (14%)      9 (15%)      3 (5%)                                
      Hemorrhage                                      11 (18%)      4 (7%)      10 (17%)     12 (20%)                               
      Hyperplasia, Lymphoid                            8 (13%)     13 (22%)     22 (37%)     25 (42%)                               
      Pigmentation                                     6 (10%)      6 (10%)      7 (12%)      8 (14%)                               
   Lymph Node, Mesenteric                             (60)         (59)         (60)         (60)                                   
      Ectasia                                          8 (13%)      1 (2%)       2 (3%)       3 (5%)                                
      Hemorrhage                                                                10 (17%)      7 (12%)                               
      Hyperplasia, Lymphoid                            3 (5%)       2 (3%)      10 (17%)     14 (23%)                               
      Pigmentation                                                               1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)       3 (5%)       1 (2%)                                
      Fibrosis                                        15 (25%)     16 (27%)     19 (32%)     17 (28%)                               
      Hematopoietic Cell Proliferation                15 (25%)     12 (20%)     16 (27%)     16 (27%)                               
      Metaplasia, Lipocyte                                                                    2 (3%)                                
      Necrosis                                                      1 (2%)                                                          
      Pigmentation                                     9 (15%)     12 (20%)     14 (23%)     11 (18%)                               
      Lymphoid Follicle, Hyperplasia                                                          1 (2%)                                
   Thymus                                             (58)         (58)         (58)         (59)                                   
      Hyperplasia                                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (57)         (56)         (58)                                   
      Hyperplasia                                     23 (40%)     11 (19%)     12 (21%)      7 (12%)                               
   Skin                                               (60)         (58)         (60)         (60)                                   
      Cyst Epithelial Inclusion                        3 (5%)       1 (2%)       1 (2%)                                             
      Hyperkeratosis                                   4 (7%)       3 (5%)       3 (5%)       8 (13%)                               
      Ulcer                                            2 (3%)                                 1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Epidermis, Hyperplasia                           5 (8%)       5 (9%)       5 (8%)       9 (15%)                               
      Subcutaneous Tissue, Edema                                    1 (2%)       4 (7%)      16 (27%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fibrous Osteodystrophy                           2 (3%)       8 (13%)     18 (30%)     14 (23%)                               
      Hyperostosis                                     1 (2%)                    1 (2%)                                             
   Skeletal Muscle                                    (1)          (2)          (5)          (9)                                    
      Edema                                                         1 (50%)      4 (80%)      9 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Developmental Malformation                       8 (13%)      4 (7%)       4 (7%)       3 (5%)                                
      Hemorrhage                                                                 2 (3%)       1 (2%)                                
      Hydrocephalus                                    2 (3%)                    1 (2%)       1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                                              2 (3%)                                
      Cyst                                                                       1 (2%)                                             
      Edema                                            1 (2%)       6 (10%)     10 (17%)     19 (32%)                               
      Hemorrhage                                       2 (3%)       2 (3%)                    3 (5%)                                
      Infiltration Cellular, Histiocyte               19 (32%)     15 (25%)     20 (33%)     15 (25%)                               
      Inflammation, Subacute                           2 (3%)       7 (12%)      2 (3%)       4 (7%)                                
      Metaplasia, Osseous                                                                     2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 4 (7%)       6 (10%)      2 (3%)       3 (5%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Exudate                                          8 (13%)      7 (12%)     10 (17%)     10 (17%)                               
      Foreign Body                                     2 (3%)                    2 (3%)       6 (10%)                               
      Mucosa, Hyperplasia                              5 (8%)       8 (13%)      9 (15%)      8 (13%)                               
      Mucosa, Metaplasia, Squamous                     7 (12%)      4 (7%)       7 (12%)      8 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                    (4)                                    
      Cataract                                         1 (100%)                               1 (25%)                               
      Congestion                                                                              1 (25%)                               
      Hemorrhage                                                                              2 (50%)                               
      Retina, Degeneration                             1 (100%)                               1 (25%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05128-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                             1 (2%)       6 (10%)      7 (12%)      8 (13%)                               
      Hydronephrosis                                                2 (3%)                    1 (2%)                                
      Infarct                                                                    1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       5 (8%)       4 (7%)                                
      Mineralization                                   6 (10%)                                2 (3%)                                
      Nephropathy                                     60 (100%)    60 (100%)    60 (100%)    60 (100%)                              
      Pelvis, Hemorrhage                                                                      1 (2%)                                
      Renal Tubule, Hyperplasia                                                  4 (7%)       3 (5%)                                
      Renal Tubule, Pigmentation                      18 (30%)     50 (83%)     56 (93%)     60 (100%)                              
      Transitional Epithelium, Hyperplasia            11 (18%)     23 (38%)     29 (48%)     34 (57%)                               
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                                              1 (2%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.