https://ntp.niehs.nih.gov/go/2212

TDMS Study 05128-06 Pathology Tables

NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96
Route: DOSED FEED                                                                                                 Time: 23:34:28
       Facility:  Southern Research Institute
       Chemical CAS #:  8003-22-3
       Lock Date:  01/12/93
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9           10            9                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           23           12           25                                     
    Natural Death                                      3            2            1            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           26           37           23                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Colon                             (60)         (58)         (59)         (60)                                   
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Intestine Large, Rectum                            (59)         (59)         (59)         (59)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Intestine Large, Cecum                             (60)         (60)         (59)         (59)                                   
   Intestine Small, Jejunum                           (59)         (60)         (60)         (60)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Ileum                             (58)         (60)         (59)         (58)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Cholangiocarcinoma                               1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma                                                                1 (2%)                                
      Hepatocellular Adenoma                                        1 (2%)       5 (8%)       4 (7%)                                
      Hepatocellular Adenoma, Multiple                              1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Mesentery                                          (12)         (20)         (8)          (14)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (7%)                                
      Osteosarcoma, Metastatic, Bone                                1 (5%)                                                          
   Oral Mucosa                                        (1)          (1)                       (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
      Squamous Cell Papilloma                          1 (100%)     1 (100%)                                                        
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Salivary Glands                                    (60)         (55)         (60)         (59)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                       2 (3%)                    2 (3%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
   Tongue                                                                                    (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (60)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Schwannoma Malignant                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                       1 (2%)                                                          
   Adrenal Medulla                                    (58)         (60)         (59)         (59)                                   
      Pheochromocytoma Malignant                                                 1 (2%)       1 (2%)                                
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (58)         (57)         (57)         (59)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Pars Distalis, Adenoma                          23 (38%)     23 (38%)     18 (30%)     22 (37%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
      Pars Distalis, Carcinoma                                                                2 (3%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Bilateral, Follicular Cell, Carcinoma                                                   1 (2%)                                
      C-Cell, Adenoma                                  2 (3%)       2 (3%)       4 (7%)       5 (8%)                                
      C-Cell, Adenoma, Multiple                                                               1 (2%)                                
      C-Cell, Carcinoma                                             1 (2%)       1 (2%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)       2 (3%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (59)         (59)         (59)         (60)                                   
      Adenoma                                         11 (19%)      4 (7%)       5 (8%)       4 (7%)                                
      Carcinoma                                        5 (8%)       3 (5%)       6 (10%)      3 (5%)                                
      Bilateral, Carcinoma                             1 (2%)                                                                       
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa Cell Tumor Benign                                                1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Uterus                                             (60)         (60)         (60)         (60)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont                                                                                                               
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Polyp Stromal                                   13 (22%)     13 (22%)     10 (17%)      6 (10%)                               
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Schwannoma Malignant                             1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (10)         (13)         (13)         (17)                                   
   Lymph Node, Mandibular                             (60)         (60)         (60)         (58)                                   
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)                                   
   Lymph Node, Mediastinal                            (1)          (3)          (2)          (3)                                    
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (33%)                               
   Spleen                                             (60)         (59)         (60)         (60)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
   Thymus                                             (60)         (58)         (59)         (58)                                   
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Adenoma                                          2 (3%)                                                                       
      Carcinoma                                        5 (8%)       5 (8%)       2 (3%)       4 (7%)                                
      Carcinoma, Multiple                                                        1 (2%)                                             
      Fibroadenoma                                    14 (23%)     13 (22%)     18 (30%)     17 (28%)                               
      Fibroadenoma, Multiple                           7 (12%)      9 (15%)      5 (8%)       9 (15%)                               
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Skin                                               (59)         (60)         (60)         (60)                                   
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Squamous Cell Carcinoma                                                    2 (3%)                                             
      Squamous Cell Papilloma                                       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                     1 (2%)       1 (2%)                    1 (2%)                                
   Skeletal Muscle                                                 (2)                       (1)                                    
      Osteosarcoma, Metastatic, Bone                                1 (50%)                                                         
      Rhabdomyosarcoma                                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Malignant                                         1 (2%)                                                          
      Carcinoma, Metastatic, Pituitary Gland                                                  2 (3%)                                
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                    2 (3%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                                          2 (3%)                                
      Carcinoma, Metastatic, Uterus                    1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Sarcoma                                                                    1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
      Transitional Epithelium, Hemangioma                                        1 (2%)                                             
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Papilloma                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            16 (27%)     21 (35%)     19 (32%)     16 (27%)                               
      Lymphoma Malignant                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            52          53          53          53                                       
     Total Primary Neoplasms                          115         111         110         119                                       
   Total Animals with Benign Neoplasms                 44          46          44          43                                       
     Total Benign Neoplasms                            80          74          74          78                                       
   Total Animals with Malignant Neoplasms              32          30          30          30                                       
     Total Malignant Neoplasms                         35          37          36          41                                       
   Total Animals with Metastatic Neoplasms              1           1                       4                                       
     Total Metastatic Neoplasm                          1           5                       8                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9            9            6                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                29           29           41           49                                     
    Natural Death                                      2            2            1            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           20            8            2                                     
  Other                                                                          1                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Colon                             (59)         (59)         (58)         (59)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Cecum                             (60)         (59)         (59)         (60)                                   
      Hemangioma                                                                              1 (2%)                                
   Intestine Small, Jejunum                           (60)         (59)         (60)         (60)                                   
      Carcinoma                                        1 (2%)                                 1 (2%)                                
   Intestine Small, Ileum                             (59)         (59)         (59)         (60)                                   
      Carcinoma                                                                               1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hepatocellular Adenoma                           1 (2%)       2 (3%)       1 (2%)       6 (10%)                               
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
   Mesentery                                          (12)         (12)         (10)         (13)                                   
      Lipoma                                           1 (8%)                                                                       
   Oral Mucosa                                                     (2)          (3)          (4)                                    
      Squamous Cell Carcinoma                                       1 (50%)      1 (33%)      1 (25%)                               
      Squamous Cell Papilloma                                       1 (50%)      1 (33%)      2 (50%)                               
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Acinar Cell, Adenoma                                          1 (2%)       4 (7%)       2 (3%)                                
   Salivary Glands                                    (60)         (60)         (59)         (60)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                       2 (3%)                                                          
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Carcinoma                                                     1 (2%)                                                          
   Tongue                                             (1)          (1)          (1)          (4)                                    
      Squamous Cell Carcinoma                                       1 (100%)                                                        
      Squamous Cell Papilloma                          1 (100%)                  1 (100%)     2 (50%)                               
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (60)         (60)         (60)         (60)                                   
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
   Adrenal Medulla                                    (60)         (59)         (60)         (60)                                   
      Neuroblastoma Malignant                                                    1 (2%)                                             
      Pheochromocytoma Malignant                       4 (7%)       1 (2%)       2 (3%)                                             
      Pheochromocytoma Benign                          7 (12%)      8 (14%)     11 (18%)      6 (10%)                               
      Bilateral, Pheochromocytoma Benign                                         1 (2%)       2 (3%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          4 (7%)       3 (5%)                                                          
      Carcinoma                                        1 (2%)                    2 (3%)                                             
   Pituitary Gland                                    (60)         (59)         (58)         (58)                                   
      Pars Distalis, Adenoma                          21 (35%)      7 (12%)     13 (22%)      8 (14%)                               
      Pars Distalis, Adenoma, Multiple                              1 (2%)       1 (2%)       2 (3%)                                
      Pars Intermedia, Adenoma                                      1 (2%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (59)         (60)                                   
      C-Cell, Adenoma                                  5 (8%)       2 (3%)       3 (5%)       3 (5%)                                
      C-Cell, Adenoma, Multiple                        1 (2%)       1 (2%)                                                          
      C-Cell, Carcinoma                                                          1 (2%)       1 (2%)                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                       3 (5%)       1 (2%)       1 (2%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   Peritoneum                                         (2)          (1)          (3)          (3)                                    
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (59)         (60)         (60)         (60)                                   
   Preputial Gland                                    (59)         (59)         (60)         (60)                                   
      Adenoma                                          5 (8%)       2 (3%)       1 (2%)                                             
      Carcinoma                                        5 (8%)       4 (7%)       1 (2%)       2 (3%)                                
   Prostate                                           (60)         (60)         (60)         (59)                                   
      Adenocarcinoma                                                1 (2%)                                                          
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
   Testes                                             (59)         (60)         (60)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           30 (51%)     36 (60%)     42 (70%)     39 (65%)                               
      Interstitial Cell, Adenoma                       9 (15%)     13 (22%)      7 (12%)      7 (12%)                               
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (22)         (25)         (30)         (47)                                   
      Renal, Pheochromocytoma Malignant,                                                                                            
          Metastatic, Adrenal Medulla                  1 (5%)                                                                       
   Lymph Node, Mandibular                             (60)         (59)         (59)         (59)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (59)         (60)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (58)         (58)         (58)         (59)                                   
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (58)         (57)         (56)         (58)                                   
      Fibroadenoma                                     3 (5%)       2 (4%)       3 (5%)       1 (2%)                                
   Skin                                               (60)         (58)         (60)         (60)                                   
      Basal Cell Adenoma                               1 (2%)       1 (2%)       2 (3%)                                             
      Basal Cell Carcinoma                                                       2 (3%)                                             
      Keratoacanthoma                                  7 (12%)      4 (7%)       2 (3%)       1 (2%)                                
      Squamous Cell Papilloma                          3 (5%)       3 (5%)       2 (3%)       3 (5%)                                
      Trichoepithelioma                                1 (2%)                                                                       
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Sebaceous Gland, Carcinoma                       1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                     3 (5%)       2 (3%)       3 (5%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (2)          (5)          (9)                                    
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (60)         (60)         (60)         (60)                                   
      Hemangioma                                       1 (2%)                                                                       
   Spinal Cord                                        (1)          (2)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     7 (12%)      1 (2%)       2 (3%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                    1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Zymbal's Gland                                                               (1)          (1)                                    
      Carcinoma                                                                  1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Renal Tubule, Adenoma                                                                   2 (3%)                                
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            37 (62%)     36 (60%)     20 (33%)     22 (37%)                               
      Lymphoma Malignant                               1 (2%)                                                                       
      Mesothelioma Malignant                           2 (3%)       2 (3%)       3 (5%)       4 (7%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05128-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 23:34:28  
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         FISCHER 344 RATS MALE                     UNTREATD     0.05%        0.17%        0.5%                                      
                                                   CONTROL                                                                          
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TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            51          55          51          50                                       
     Total Primary Neoplasms                          171         144         140         128                                       
   Total Animals with Benign Neoplasms                 50          53          50          50                                       
     Total Benign Neoplasms                           112          95         103          90                                       
   Total Animals with Malignant Neoplasms              42          40          30          26                                       
     Total Malignant Neoplasms                         59          49          37          38                                       
   Total Animals with Metastatic Neoplasms              2                       1                                                   
     Total Metastatic Neoplasm                          3                       3                                                   
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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