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TDMS Study 05128-06 Pathology Tables

NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95
Route: DOSED FEED                                                                                                 Time: 12:27:37

                                                          CORE ANIMALS




       Facility:  Southern Research Institute

       Chemical CAS #:  8003-22-3

       Lock Date:  01/12/93

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All



































                                                              Page   1

NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 6| 1| 4| 0| 8| 4| 4| 9| 7| 4| 0| 4| 4| 4|             
                                           | 2| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 0| 2| 2| 7| 4| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X     X  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                              2                           |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X     X  X     X  X     X     X        X        X  X        X   |             
      Clear Cell Focus                     |                                           X     X           X        X   |             
      Cytoplasmic Alteration               |                               3     3                                    |             
      Eosinophilic Focus                   |          X              X        X        X     X                 X      |             
      Granuloma                            |                   1     1  1     1     2                    1     1      |             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Hepatodiaphragmatic Nodule           |                   X                          X                 X         |             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     | X                                               X  X  X           X  X   |             
      Necrosis, Focal                      |                                              4                           |             
      Bile Duct, Hyperplasia               |    1           2     1                                      1     1  1  1|             
      Centrilobular, Atrophy               |                                                                3        2|             
      Centrilobular, Necrosis              |                                                       3                  |             
      Hepatocyte, Vacuolization Cytoplasmic|                      4              3        4                          3|             
      Kupffer Cell, Pigmentation           |    2                 2        2                                         2|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +        +                    +  +           +               |             
      Accessory Spleen                     |                                                                          |             
      Angiectasis                          |                                                                          |             
      Fat, Necrosis                        |             2        3                    3  3           2               |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3           1        3        1                                1         |             
      Acinar Cell, Cytoplasmic Alteration  |                                     4                          4         |             
      Acinar Cell, Hyperplasia, Focal      |                   1                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             3                       3     3                             2|             
      Fibrosis                             |                                                                          |             
      Ulcer                                |             4                 2     1     3                              |             
      Mucosa, Hyperplasia                  |             2                       3     3                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 6| 1| 4| 0| 8| 4| 4| 9| 7| 4| 0| 4| 4| 4|             
                                           | 2| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 0| 2| 2| 7| 4| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                           2           2                  |             
      Ulcer                                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2        2        1        1        1  1                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                          2              2|             
      Degeneration, Fatty                  |             1        1              2        1                          1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |             1              2                                             |             
      Hypertrophy, Focal                   |                                                                1         |             
      Hypertrophy                          |                                  3                                2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                3         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  2     3                                 |             
      Pars Distalis, Cyst                  |    3        3        3        3  3     3                 3     3        3|             
      Pars Distalis, Hyperplasia, Focal    |                      2        2  3     3                                 |             
      Pars Intermedia, Angiectasis         |                                                                         3|             
      Pars Intermedia, Hyperplasia         |                               3                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                   3      |             
      C-Cell, Hyperplasia                  | 1     3        1  1                                               1      |             
      Follicular Cell, Hyperplasia         |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               3                       2                  |             
      Hyperplasia                          |                                                       2        2         |             
      Inflammation, Suppurative            |          2                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3        3              3                 3                       3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 6| 1| 4| 0| 8| 4| 4| 9| 7| 4| 0| 4| 4| 4|             
                                           | 2| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 0| 2| 2| 7| 4| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                              2                           |             
      Hyperplasia, Cystic                  |                                     1     1  2     4                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |             M                             M                    M         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          3               |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Myelofibrosis                        |                      3                 2                                 |             
      Necrosis                             |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                +                 +         |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hemorrhage              |                                              3                           |             
      Mediastinal, Pigmentation            |                                              4                 3         |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                                   |             
      Hemorrhage                           | 2        2                                   2     2        1     3      |             
      Hyperplasia, Lymphoid                |                                     2                                2   |             
      Pigmentation                         | 2           2  2  2        2  2  2  2     2     2  2  2  2        2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               2     2  1  4  3                           |             
      Hyperplasia, Lymphoid                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  3  1        2        2  4  1        4  3  1  2     3  1     2  2   |             
      Infiltration Cellular, Histiocyte    |                                        4                                 |             
      Necrosis                             |             3                                                            |             
      Pigmentation                         | 3     3  3        2     2  2  3  2  4  2        2  2  3     3     3  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2     3  2  4  2  3  4  2  4  2  3  2  2  3  3  3  2  2  2  3  3  2  4|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Cranium, Osteopetrosis               |             3        2              2                       2            |             
      Femur, Osteopetrosis                 |             2                                               3            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 7| 2| 1| 8| 5| 2| 3| 5| 6| 1| 4| 0| 8| 4| 4| 9| 7| 4| 0| 4| 4| 4|             
                                           | 2| 2| 1| 1| 2| 9| 9| 0| 9| 0| 6| 0| 2| 2| 7| 4| 2| 2| 9| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    UNTREATD                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           | X     X                 X           X                 X     X            |             
      Hydrocephalus                        |                                                                   2      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1        1     1     1  1  1     1  1           1     1  1  1     1  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |       3              3                          3     3                  |             
      Foreign Body                         |       X                                               X                  |             
      Mucosa, Hyperplasia                  |       1              1                                                   |             
      Mucosa, Metaplasia, Squamous         |                      1                          2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 3  2  2  2  3  3  3  2  3  3  3  2  3  3     3  3  3  3  3  2  2  3  3  3|             
      Nephropathy                          | 3  1  1  1  1  1  1     1  1  1  1  4  1  1  1  3  3  2  1  2     1  1  1|             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Necrosis               |                                                                3         |             
      Renal Tubule, Pigmentation           |    1  1                       1              2                          3|             
      Transitional Epithelium, Hyperplasia |                                     1                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7|            |
                             DAY ON TEST   | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4|            |
                                           | 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X                                                                  |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                   X                                         X            |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       2                  |      1  2.0|
      Basophilic Focus                     | X     X  X  X  X  X  X  X     X  X  X     X     X  X  X     X     X     X|     32     |
      Clear Cell Focus                     |                X  X     X     X        X                          X      |     10     |
      Cytoplasmic Alteration               |                                                                          |      2  3.0|
      Eosinophilic Focus                   |                   X                       X              X     X         |     10     |
      Granuloma                            |             1                 1                             1            |     10  1.1|
      Hematopoietic Cell Proliferation     |                                                    2                     |      2  2.0|
      Hepatodiaphragmatic Nodule           |    X           X  X                                            X         |      7     |
      Inflammation, Subacute               |          1              1                                                |      2  1.0|
      Mixed Cell Focus                     |       X  X                    X     X                          X     X   |     12     |
      Necrosis, Focal                      |                         1                                                |      2  2.5|
      Bile Duct, Hyperplasia               | 1                 1  2           1  1        2           2               |     14  1.3|
      Centrilobular, Atrophy               | 2                                                        2               |      4  2.3|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                      4                       3                           |      6  3.5|
      Kupffer Cell, Pigmentation           | 2                 2  3                                   3           1   |      9  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +        +           +  +        +                           |  11        |
      Accessory Spleen                     |                                  X                                       |      1     |
      Angiectasis                          |                      4                                                   |      1  4.0|
      Fat, Necrosis                        |             4                       3        3                           |      8  2.9|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3                                1                    1     3            |      9  1.9|
      Acinar Cell, Cytoplasmic Alteration  |    3                                                                     |      3  3.7|
      Acinar Cell, Hyperplasia, Focal      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7|            |
                             DAY ON TEST   | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4|            |
                                           | 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                      4                                                   |      5  3.0|
      Fibrosis                             |                                                                2         |      1  2.0|
      Ulcer                                |                                                                          |      4  2.5|
      Mucosa, Hyperplasia                  |                      2                                            2      |      5  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
      Developmental Malformation           |    X                                                                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1           1  3                 3        1     1                 3  1  1|     16  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |          2                                                           2  3|      5  2.2|
      Degeneration, Fatty                  |                   1     2              2                 1               |      9  1.3|
      Hematopoietic Cell Proliferation     |                                                    2                     |      1  2.0|
      Hyperplasia, Focal                   |                                                 2                        |      3  1.7|
      Hypertrophy, Focal                   |                   2     2                                                |      3  1.7|
      Hypertrophy                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                  2     1                                 |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           | 4  2                          2     4     3     3        3        3      |     10  2.9|
      Pars Distalis, Cyst                  | 3           3  3  3  3  3     3  3  3     3  3  3  3     3        3     3|     25  3.0|
      Pars Distalis, Hyperplasia, Focal    | 3           3     3                             3                       1|      9  2.6|
      Pars Intermedia, Angiectasis         | 3  2                                                                     |      3  2.7|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                               3                                3         |      3  3.0|
      C-Cell, Hyperplasia                  |    2                 1        1                 1     1  1  2           1|     13  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7|            |
                             DAY ON TEST   | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4|            |
                                           | 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      2  2.5|
      Hyperplasia                          |                            2                                             |      3  2.0|
      Inflammation, Suppurative            |                         3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                   3  3        3        3  3                    3  3     3|     13  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                        4                                 |      2  3.0|
      Hyperplasia, Cystic                  |                   3                                                      |      5  2.2|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                         M                       +        M           M   |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        4  3        3                     |      4  3.3|
      Infiltration Cellular, Histiocyte    |                                     4                                    |      1  4.0|
      Myelofibrosis                        | 4                                                                        |      3  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +  +           +        +     +     +               |   9        |
      Inguinal, Hyperplasia, Lymphoid      |                                                    2                     |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                         3                    3           3               |      5  3.2|
      Pancreatic, Hemorrhage               |                                     2                                    |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                    2                     |      1  2.0|
      Pancreatic, Pigmentation             |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |          2        2           1           2                              |     10  1.9|
      Hyperplasia, Lymphoid                |    4                       3                                         2   |      5  2.6|
      Pigmentation                         |          2     2     2     3                          2  2  2  2         |     23  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      5  2.4|
      Hyperplasia, Lymphoid                |                                        4                                 |      2  3.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |             3     2     3     2     3  4  3     2  3  2                 2|     27  2.4|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |       2  2  3              3  2     2           2  2  2  2  2  3     3  2|     30  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7|            |
                             DAY ON TEST   | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4|            |
                                           | 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  4     3  3  2  3  2  4  2     3  2  2  4     2  3  4  2  2  2  3  3|     46  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                              2                           |      1  2.0|
      Cranium, Osteopetrosis               |          3                                                        2      |      6  2.3|
      Femur, Osteopetrosis                 |                         2                       2        2               |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                            X                                   X     X   |      9     |
      Hydrocephalus                        |                                                                      2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                            +                             +               |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +                 +                             +               |   3        |
      Necrosis                             |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |    1     1  1  1  1  1  1  1  1  1  1  1  1  1  1        1  1     1     1|     34  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                              3                           |      5  3.0|
      Foreign Body                         |                                                                          |      2     |
      Mucosa, Hyperplasia                  |             1                                2                           |      4  1.3|
      Mucosa, Metaplasia, Squamous         |                                              1                           |      3  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
      Atrophy                              |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       | 3  3     3  2  3  3  3  3  2  3  3  3  3  1  1  3  3  2  2  3  3  2  3  2|     48  2.6|
      Nephropathy                          | 1     1  1  1  1  1  1  1  1  1  1  1  2     1  2     2  1  1  2  1  3  1|     45  1.4|
      Renal Tubule, Cytoplasmic Alteration |       3                                                                  |      1  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 4| 7| 7| 7| 5| 7| 6| 7|            |
                             DAY ON TEST   | 4| 7| 3| 4| 4| 4| 4| 3| 4| 5| 4| 3| 4| 7| 4| 8| 4| 8| 3| 0| 4| 3| 4| 2| 4|            |
                                           | 2| 2| 0| 2| 2| 2| 2| 4| 2| 1| 2| 4| 2| 0| 2| 9| 2| 1| 4| 0| 2| 7| 2| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Pigmentation           |       1              1                          1     1  1               |     10  1.3|
      Transitional Epithelium, Hyperplasia |                                        1                                 |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 5| 6| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 4| 4| 4| 7| 4| 2| 3| 4| 8| 4| 8| 2| 2| 0| 4| 4| 4| 2| 4| 0| 4|             
                                           | 4| 0| 2| 0| 0| 0| 0| 2| 0| 2| 1| 8| 8| 0| 8| 9| 6| 8| 0| 5| 0| 8| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                            X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Basophilic Focus                     | X  X     X  X  X     X  X  X     X  X     X           X     X     X      |             
      Clear Cell Focus                     | X           X  X        X              X                          X      |             
      Cyst                                 |                                           3                              |             
      Eosinophilic Focus                   |          X     X                 X        X                              |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X           X                                            X               |             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     | X           X  X     X  X  X     X     X              X     X            |             
      Necrosis, Focal                      |                1                                                  1      |             
      Thrombosis                           |                                                 3                        |             
      Bile Duct, Hyperplasia               |                   2     2     2                 2        2               |             
      Bile Duct, Pigmentation              | 2  1  1  1  1  1  1  2  1  1     1  2  1  1  1  1  1     2     2  1  1  1|             
      Centrilobular, Atrophy               |                               2              2  3  3           2         |             
      Hepatocyte, Cytologic Alterations    | 2        2                                            2     2        3   |             
      Hepatocyte, Pigmentation             |    1  1     1  1     1     1     1  1  1  1     1  1              1  1   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                              3                 4     3   |             
      Kupffer Cell, Pigmentation           |                   3           1              3  1        3     3         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                       +  +  +     +        +  +        +  +  +         |             
      Fat, Necrosis                        | 2                       2  2  3     3        3  3        3  2  2         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2        1  2           2     2     3  3        3        1  1   |             
      Acinar Cell, Cytoplasmic Alteration  |                                  3                                   4   |             
      Acinar Cell, Hyperplasia, Focal      |                1                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1  1        2                                2              2   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 5| 6| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 4| 4| 4| 7| 4| 2| 3| 4| 8| 4| 8| 2| 2| 0| 4| 4| 4| 2| 4| 0| 4|             
                                           | 4| 0| 2| 0| 0| 0| 0| 2| 0| 2| 1| 8| 8| 0| 8| 9| 6| 8| 0| 5| 0| 8| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Hyperplasia                  |       1  1     1  1                 1     1  2           2     1     2  1|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                      3   |             
      Ulcer                                |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2        1  1        1  1     1     2                          2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       2           1     1  1     1                 X  1           2      |             
      Angiectasis                          |                      3                                                   |             
      Degeneration, Fatty                  |                1  3                       1     1           1     2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                                                      2   |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis                             |                                                                      2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          2                                               4               |             
      Pars Distalis, Cyst                  | 3           3        3  3                 3  3  3              3  3      |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                 3                        |             
      C-Cell, Hyperplasia                  |          2                                                              1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 3                 3     3|             
      Hyperplasia                          |                                                                         2|             
      Inflammation, Suppurative            |                                                                         2|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                   3  3  3     3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 5| 6| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 4| 4| 4| 7| 4| 2| 3| 4| 8| 4| 8| 2| 2| 0| 4| 4| 4| 2| 4| 0| 4|             
                                           | 4| 0| 2| 0| 0| 0| 0| 2| 0| 2| 1| 8| 8| 0| 8| 9| 6| 8| 0| 5| 0| 8| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                         3           3                    4     2        2|             
      Hyperplasia, Cystic                  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                               M              M                 M         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                                       |             
      Myelofibrosis                        |                   2  2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +  +           +        +|             
      Deep Cervical, Pigmentation          |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |                                                 3                        |             
      Pancreatic, Pigmentation             |                                                 3                        |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |          1                    2                                          |             
      Hyperplasia, Lymphoid                |          2  2              2     2                                2      |             
      Pigmentation                         |          2  2  2  2     2        2        2  2           2        2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     2                                    |             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                    +                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Fibrosis                             |                               3              2                           |             
      Hematopoietic Cell Proliferation     | 2        2  1  2           2     3        1           2     2     2      |             
      Metaplasia, Osseous                  |                                                                          |             
      Pigmentation                         |    2     2  2  2     2           2     2  2  3        2     2     2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hemorrhage                           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  1     4  2  2  2  2     2  2     2  1  3     2        3  2  2  1  4  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                2         |             
      Cranium, Osteopetrosis               | 2              3           3                          2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 5| 6| 7| 6| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 2| 4| 4| 4| 4| 7| 4| 2| 3| 4| 8| 4| 8| 2| 2| 0| 4| 4| 4| 2| 4| 0| 4|             
                                           | 4| 0| 2| 0| 0| 0| 0| 2| 0| 2| 1| 8| 8| 0| 8| 9| 6| 8| 0| 5| 0| 8| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Femur, Osteopetrosis                 | 2              3     2                       2                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |    X                          X     X                             X  X   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                          +               |             
      Degeneration                         |                                                          3               |             
      Inflammation, Chronic                |                                                          3               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1        1  1  2     1  1        1           1     1  2  1     1  1  1|             
      Inflammation, Subacute               |          1                                               2               |             
      Alveolar Epithelium, Hyperplasia     |                                                       4                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                      3                                                   |             
      Foreign Body                         |                                                                   X      |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                      3                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |       +           +                                                      |             
      Cataract                             |       4           3                                                      |             
      Retina, Degeneration                 |       4           2                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1     2  1  2  3  2  2  2  2  2  2  2  1  2  3  3  1  2  2  1  2  1  2  2|             
      Nephropathy                          | 2  1     3  1  3  1  1  2  1  1  1  1  2  1  2  2  1  2  1  3  1  3  4  2|             
      Renal Tubule, Cytoplasmic Alteration |                                                             2            |             
      Renal Tubule, Pigmentation           | 2  2  1  2  2  2  2  1  1  1  1  2  2  1  1  2  3  2  2  2  2  2  2  2  2|             
      Transitional Epithelium, Hyperplasia |                                                 2                       2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 0| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 4| 4| 4| 4| 0| 4| 4| 4| 6|             
                                           | 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 6| 1| 1| 1| 1| 0| 1| 1| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X           X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |          3                                                               |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Basophilic Focus                     | X     X        X  X        X        X     X  X  X           X  X         |             
      Clear Cell Focus                     | X  X  X        X           X        X     X        X  X  X     X         |             
      Cyst                                 |                               3              3                           |             
      Eosinophilic Focus                   |    X  X                             X  X  X                              |             
      Granuloma                            |                                           1                              |             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Inflammation, Subacute               |                                                    1                     |             
      Mixed Cell Focus                     | X     X     X     X                       X     X        X     X  X      |             
      Necrosis, Focal                      |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |             1        1  2        2           1                           |             
      Bile Duct, Pigmentation              | 1  2  2  1  1  1     2     1  2  2  1  1  1  1  1  1  1  1  1  1  1  2  2|             
      Centrilobular, Atrophy               |          2           2  2                                            2   |             
      Hepatocyte, Cytologic Alterations    |                   2  3                    2        2  2                 3|             
      Hepatocyte, Pigmentation             | 1  1  1  1     1  2        1        1  1  1  1  1  1  1  1     1  1  3  2|             
      Hepatocyte, Vacuolization Cytoplasmic|          3              3     2                                          |             
      Kupffer Cell, Pigmentation           |          2           2  2        4                                   2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +     +              +                 +           +  +|             
      Fat, Necrosis                        |          2        3                    2                 4           2   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4           1           3     1     2  2     2           1      |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |             
      Acinar Cell, Hyperplasia, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +           +  +|             
      Atrophy                              |    1           2                                         1               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 0| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 4| 4| 4| 4| 0| 4| 4| 4| 6|             
                                           | 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 6| 1| 1| 1| 1| 0| 1| 1| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Hyperplasia                  | 1           1              2           1  2                       1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          2              2                                                |             
      Erosion                              |                                                                          |             
      Ulcer                                |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1  1  1  2     2     2     2     3        1              1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                               1     1                 2     1            |             
      Angiectasis                          |                                                          3               |             
      Degeneration, Fatty                  |          3                                      1        2     2         |             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Hyperplasia, Focal                   |                                              2                           |             
      Hypertrophy, Focal                   |                                                          2     3         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         3           3           3                 3      |             
      Pars Distalis, Cyst                  |    3  3           3  3     3     3        3     3  3           3  3     3|             
      Pars Distalis, Hyperplasia, Focal    | 2                                               3  2        2            |             
      Pars Intermedia, Angiectasis         |                         3                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |    3  3                                               3              3   |             
      C-Cell, Hyperplasia                  |                               1     2  2  1                       2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                2         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3     3              3           3  3        3  3  3                    3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 0| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 4| 4| 4| 4| 0| 4| 4| 4| 6|             
                                           | 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 6| 1| 1| 1| 1| 0| 1| 1| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |          2     2                                         1               |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                               M  M                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                 +  +           +              +  +        +|             
      Deep Cervical, Pigmentation          |                                                                         4|             
      Mediastinal, Hemorrhage              |                                                             1  2         |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             2           2|             
      Mediastinal, Pigmentation            |             3                    3           3              3  3        3|             
      Pancreatic, Pigmentation             |                                  3                                       |             
      Renal, Hemorrhage                    |                               2                                          |             
      Renal, Pigmentation                  |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                  3              3                       2|             
      Hemorrhage                           |    1           2  1           1     3           1  1           2        2|             
      Hyperplasia, Lymphoid                |    2                          3                    2     2  2            |             
      Pigmentation                         |    2     2     2                    2  2  2     2  2  2     2  2        4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                     3     2     2                        |             
      Pigmentation                         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      2                                                   |             
      Hematopoietic Cell Proliferation     | 2           2     2           2     2     2     2  2     2  2  2        4|             
      Metaplasia, Osseous                  |                                              3                           |             
      Pigmentation                         | 3  2  2     3  2  2           2  2  2  3  2     2  2  2  3     2     2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  1  2  3  2  2  2  3  2  2  2  2  4  3  2  3  2  2  3        1  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Cranium, Osteopetrosis               |          3  3                                                           2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 0| 4| 4| 3| 9| 4| 1| 1| 4| 9| 4| 5| 4| 4| 4| 4| 0| 4| 4| 4| 6|             
                                           | 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 6| 2| 1| 3| 1| 6| 1| 1| 1| 1| 0| 1| 1| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05%                                  | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Femur, Osteopetrosis                 |             3        2                                                  3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                       +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |             X  X              X        X                             X   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                               +                                          |             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1     2  1     1  1  1  1  1  2     1        1     1  1  1     1     2  1|             
      Inflammation, Subacute               |                                                                   1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                      1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                      3           3              3  3                     |             
      Foreign Body                         |                                                                          |             
      Mucosa, Hyperplasia                  |                                  1              2                        |             
      Mucosa, Metaplasia, Squamous         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 2  2  2  2  2  1  1  3     1  2  2  1  2  1  2  1  1  2  1  2  2  3  2  1|             
      Nephropathy                          | 1  2  1  1  3  1  2  2  1  2  2     1  3  1  1  2  1  2  1     1  2  1   |             
      Renal Tubule, Cytoplasmic Alteration |                                                          3               |             
      Renal Tubule, Pigmentation           | 2  2  2  2     2  1  3  3  1  1  3  1  1  1     2  1  2  2     2  2  3  1|             
      Transitional Epithelium, Hyperplasia |          1                       1                             1  1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 1|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    0.05%                                  | 6|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  50        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  51        |
      Edema                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  51        |
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  51        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  51        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     | X                                                                        |     26     |
      Clear Cell Focus                     | X                                                                        |     18     |
      Cyst                                 |                                                                          |      3  3.0|
      Eosinophilic Focus                   |                                                                          |      9     |
      Granuloma                            |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |     19     |
      Necrosis, Focal                      |                                                                          |      2  1.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                          |     10  1.7|
      Bile Duct, Pigmentation              | 1                                                                        |     46  1.3|
      Centrilobular, Atrophy               |                                                                          |      9  2.2|
      Hepatocyte, Cytologic Alterations    |                                                                          |     11  2.3|
      Hepatocyte, Pigmentation             | 1                                                                        |     34  1.1|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      6  3.0|
      Kupffer Cell, Pigmentation           |                                                                          |     11  2.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |  18        |
      Fat, Necrosis                        | 2                                                                        |     16  2.5|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Atrophy                              | 1                                                                        |     19  1.9|
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 1|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    0.05%                                  | 6|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinar Cell, Hyperplasia, Focal      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  46        |
      Atrophy                              |                                                                          |      8  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Ulcer                                |                                                                          |      1  4.0|
      Mucosa, Hyperplasia                  |                                                                          |     17  1.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Edema                                |                                                                          |      2  2.0|
      Erosion                              |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Cardiomyopathy                       |                                                                          |     18  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Accessory Adrenal Cortical Nodule    | 2                                                                        |     13  1.3|
      Angiectasis                          |                                                                          |      2  3.0|
      Degeneration, Fatty                  |                                                                          |     10  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hypertrophy, Focal                   |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  51        |
      Pars Distalis, Angiectasis           |                                                                          |      6  3.0|
      Pars Distalis, Cyst                  |                                                                          |     21  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      4  2.3|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Ultimobranchial Cyst                 |                                                                          |      5  3.0|
      C-Cell, Hyperplasia                  |                                                                          |      7  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 1|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    0.05%                                  | 6|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  50        |
      Cyst                                 |                                                                          |      4  2.8|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  51        |
      Cyst                                 |                                                                          |     14  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Hydrometra                           |                                                                          |      8  2.4|
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  11        |
      Deep Cervical, Pigmentation          |                                                                          |      1  4.0|
      Mediastinal, Hemorrhage              |                                                                          |      2  1.5|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.0|
      Mediastinal, Pigmentation            |                                                                          |      7  3.0|
      Pancreatic, Pigmentation             |                                                                          |      2  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  51        |
      Ectasia                              |                                                                          |      3  2.7|
      Hemorrhage                           |                                                                          |     11  1.5|
      Hyperplasia, Lymphoid                |                                                                          |     10  2.1|
      Pigmentation                         | 2                                                                        |     24  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 2                                                                        |      5  2.2|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  50        |
      Fibrosis                             |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     | 2                                                                        |     23  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Pigmentation                         | 2                                                                        |     30  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 1|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    0.05%                                  | 6|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
      Hyperplasia                          | 2                                                                        |     42  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Hyperostosis                         |                                                                          |      1  2.0|
      Cranium, Osteopetrosis               |                                                                          |      7  2.6|
      Femur, Osteopetrosis                 |                                                                          |      7  2.4|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Developmental Malformation           | X                                                                        |     11     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
      Degeneration                         |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Infiltration Cellular, Histiocyte    | 1                                                                        |     33  1.2|
      Inflammation, Subacute               |                                                                          |      3  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Exudate                              |                                                                          |      5  3.0|
      Foreign Body                         |                                                                          |      1     |
      Mucosa, Hyperplasia                  |                                                                          |      2  1.5|
      Mucosa, Metaplasia, Squamous         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  3.5|
      Retina, Degeneration                 |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 1|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    0.05%                                  | 6|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Inflammation, Suppurative            | 1                                                                        |      1  1.0|
      Mineralization                       | 2                                                                        |     49  1.8|
      Nephropathy                          | 3                                                                        |     47  1.7|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      2  2.5|
      Renal Tubule, Pigmentation           | 1                                                                        |     48  1.8|
      Transitional Epithelium, Hyperplasia |                                                                          |      6  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 4| 4| 4| 4| 9| 5| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 0| 1| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.17%                                  | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X           X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                      X     X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2     2                                             |             
      Basophilic Focus                     |                            X  X  X        X  X     X           X         |             
      Clear Cell Focus                     | X  X        X  X  X     X  X  X     X     X     X     X  X  X     X  X  X|             
      Cyst                                 |                                                       2              4   |             
      Eosinophilic Focus                   | X                             X  X        X        X  X  X     X         |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X                                   X  X  X                           |             
      Inflammation, Subacute               | 1                                         1                              |             
      Mixed Cell Focus                     | X              X  X           X  X  X           X     X  X     X  X      |             
      Necrosis, Focal                      |                                        1  1                              |             
      Thrombosis                           |          2                                                               |             
      Bile Duct, Hyperplasia               | 1     2  2  2           1     2  1     1     1  1  2                     |             
      Bile Duct, Pigmentation              | 2  2  2  2  2  3  2  2  2  2  2  2  3  2  2  2  2  1  2  2  2  2  2  2  1|             
      Centrilobular, Atrophy               |       2              3                 3                                 |             
      Hepatocyte, Cytologic Alterations    | 2  2     2  2  2  2           2  2  2     2     2  2  2  3  2  2  3  2   |             
      Hepatocyte, Pigmentation             | 2  2     2     3  2     2  3  2  2  3  2  2  2  2  2  2  2  1  2  2  2  3|             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           | 2     2  2           3  1           1           1  3                    1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                 +  +                              |             
      Fat, Necrosis                        |                      3                 2  2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1                                         2  1  4        2|             
      Necrosis                             |                                        4                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                1              1  2              1      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      2                                                   |             
      Mucosa, Hyperplasia                  |       2           2     2  1        1        2  2     1  1  2        1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 4| 4| 4| 4| 9| 5| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 0| 1| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.17%                                  | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2              1  1  2        2  1                          2  2  2      |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 2  1                 1  1              3                 1               |             
      Angiectasis                          |                                                                          |             
      Degeneration, Fatty                  | 1                       1                                            2   |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                         2|             
      Hypertrophy, Focal                   | 3                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                                     1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2           2     2        3        2              3  3  3     2  2   |             
      Pars Distalis, Cyst                  | 3  3  3  3  3  3           3        3  3     3     3     3  3        3  3|             
      Pars Distalis, Hyperplasia, Focal    |    2     3                                                        2      |             
      Pars Intermedia, Angiectasis         |                                  2                                       |             
      Pars Intermedia, Cyst                |             3                                3                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                   3                       3                    3         |             
      C-Cell, Hyperplasia                  | 2                    3     1                 1  2        1               |             
      Follicle, Cyst                       |             3                                      3        3            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            3                                         2   |             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                       3        3              3     3  3        3      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                 2              2         |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                        M                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 4| 4| 4| 4| 9| 5| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 0| 1| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.17%                                  | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +        +     +                 +                                 |             
      Mediastinal, Hemorrhage              |                1     3                                                   |             
      Mediastinal, Hyperplasia, Lymphoid   |    2                                                                     |             
      Mediastinal, Pigmentation            |    3           3     3                 3                                 |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Pigmentation             |                      4                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    2                 2                          2           2            |             
      Hemorrhage                           |             1           1           2        1  1        1  2  3  2  1  2|             
      Hyperplasia, Lymphoid                |    3                             3        4  2     2  2        2  2  2   |             
      Pigmentation                         |    2                       2     2              2           2     2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          1                                                               |             
      Hyperplasia, Lymphoid                |                   2                          2                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2                                                                        |             
      Hematopoietic Cell Proliferation     | 1        3     2        2     2  2  2  3  2     2     2  2     2  2     2|             
      Necrosis                             |                      4                                                   |             
      Pigmentation                         |    2              2     2     2  3        3  2  2     2  2  3  3  3  2  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  2  3  2  2     3  2  2     3  1  3  2  2     2     1     1     4   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                     2           2                        |             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                         X        X        X     X              X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           2                              |             
      Infiltration Cellular, Histiocyte    |    1  1     1     1     1  1        2  1  1  1  1  1  1  1  1     1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 4| 4| 4| 4| 9| 5| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 0| 1| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.17%                                  | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                    3           3         |             
      Foreign Body                         |       X                                                        X         |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                                                    1           2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2  2  2  2  2  2  3  2  2  2  1  1  2  2  1  1  2  2  2  2  2  2  2  2|             
      Nephropathy                          | 1  2     1  2  2  1  2  3  2  1  1  1  1  2  1  3  1  1  2  1  2  1  1  3|             
      Renal Tubule, Cytoplasmic Alteration |                                        3                                 |             
      Renal Tubule, Pigmentation           | 3  3  4  3  3  3  2  4  2  3  3  3  3  3  2  2  3  3  3  3  3  3  3  2  2|             
      Transitional Epithelium, Hyperplasia |    3              1           2                          1     1        1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 4| 2| 4| 4|            |
                                           | 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 1| 1| 6| 0| 1| 2| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.17%                                  | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                    X     X               |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    | X                                                     X                 X|      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                              3                           |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                            3                                             |      3  2.3|
      Basophilic Focus                     |       X                 X           X                                X   |     11     |
      Clear Cell Focus                     | X  X              X     X  X     X  X           X  X  X     X  X         |     29     |
      Cyst                                 |                   3  3                                                   |      4  3.0|
      Eosinophilic Focus                   |    X  X              X           X  X                                   X|     14     |
      Granuloma                            |                         1                                                |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                          3  2            |      2  2.5|
      Hepatodiaphragmatic Nodule           |                                        X                                 |      5     |
      Inflammation, Subacute               |                                                 1                        |      3  1.0|
      Mixed Cell Focus                     |             X     X  X     X     X     X        X     X                 X|     20     |
      Necrosis, Focal                      |                                                 1  1              1      |      5  1.0|
      Thrombosis                           |             3                                                            |      2  2.5|
      Bile Duct, Hyperplasia               |    1  2  2  2     2  2  1     1     1     2  2  1  1     1           2  1|     27  1.5|
      Bile Duct, Pigmentation              | 1  2  2     2  2  1  3  2  2  3  2  2  2  2  2  2  2  2  2  1  2  2  2  2|     49  2.0|
      Centrilobular, Atrophy               |          2  2                                                            |      5  2.4|
      Hepatocyte, Cytologic Alterations    | 2        2     2           2     2  2        2     2  2  3     2  2     2|     31  2.1|
      Hepatocyte, Pigmentation             | 1  3     1     2     3  1  2  3  3  2  3  1  1  2  2  3  2  2  2  2  1  3|     44  2.1|
      Hepatocyte, Vacuolization Cytoplasmic|                                              4                    4      |      2  4.0|
      Kupffer Cell, Pigmentation           |          2  2           1                    2              1     2  2   |     16  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +  +        +     +     +               |   8        |
      Fat, Necrosis                        |                                  4  2        2     3     2               |      8  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3  1     3           1     3  3  2  1     2  3  2              1      |     17  2.1|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                         2                                               2|      7  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                              2                           |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 4| 2| 4| 4|            |
                                           | 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 1| 1| 6| 0| 1| 2| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.17%                                  | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Hyperplasia                  |    1  1     2  2  2     2  1  1  2  2  1  1  2     2  2     2  1  2     1|     30  1.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |          2                                                               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy                          |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2           2                    2  2  2           1  1  1        3      |     18  1.7|
      Thrombosis                           |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |          2  1     2                    3                       2         |     11  1.7|
      Angiectasis                          |    3              3                                                      |      2  3.0|
      Degeneration, Fatty                  |    3                 2                          2     1     4     3      |      9  2.1|
      Hyperplasia, Diffuse                 |                                                             4            |      1  4.0|
      Hyperplasia, Focal                   |       1                                                                  |      2  1.5|
      Hypertrophy, Focal                   |                                     1                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                   3  2   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |       3           4           2                       2        4        3|     16  2.6|
      Pars Distalis, Cyst                  | 3     3        3        3                 3  3     3     3     3  3      |     25  3.0|
      Pars Distalis, Hyperplasia, Focal    | 2     2           3     3                                               2|      8  2.4|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                      3                                                   |      4  3.0|
      C-Cell, Hyperplasia                  | 1                                3  2                             2      |     10  1.8|
      Follicle, Cyst                       |                                                                   3      |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05128-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        D & C YELLOW NO. 11                                    Date: 10/30/95  
Route: DOSED FEED                                                                                                 Time: 12:27:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 4| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 2| 4| 4| 4| 7| 4| 3| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 4| 2| 4| 4|            |
                                           | 1| 1| 1| 9| 2| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 1| 1| 6| 0| 1| 2| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.17%                                  | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|      L     |
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Cyst