TDMS Study 05130-02 Pathology Tables
NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 Facility: Microbiological Associates Chemical CAS #: 10401-500 Lock Date: 10/29/91 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7| DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4| | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + A + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 2 2 | Basophilic Focus | X | Clear Cell Focus | X X | Cyst | | Eosinophilic Focus | X X X X X | Fatty Change, Focal | 3 | Infiltration Cellular, Histiocyte | 2 | Inflammation, Chronic, Focal | 2 | Mixed Cell Focus | X | Necrosis, Focal | 1 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis, Focal | 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | | Infiltration Cellular, Focal, | | Lymphocyte | | Inflammation, Chronic Active, Focal | 2 | Acinar Cell, Hypertrophy, Focal | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Arteriole, Inflammation, Chronic, | | Multifocal | 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Arteriole, Inflammation, Chronic, | | Focal | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7| DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4| | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Congestion | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Parathyroid Gland | + + M + M + M + + M M M M + + M + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| Pars Distalis, Angiectasis, Focal | 2 | Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia, Focal | 2 2 1| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Lymphocyte | | Arteriole, Inflammation, Chronic, | | Focal | 3 | Follicle, Dilatation, Focal | 2 | Follicular Cell, Hyperplasia, Focal | 1 1 2 2| Follicular Cell, Hypertrophy, Focal | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Cyst | X X 1 | Hemorrhage, Focal | 2 | Inflammation, Chronic, Focal | 4 | Bilateral, Abscess | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 3 2 2 2 2 | Inflammation, Acute | 2 | Inflammation, Chronic Active | 2 | Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hyperplasia, Lymphoid | | Hyperplasia | 3 2 3 | __________________________________________________________________________| Lymph Node | + + + + + + | Iliac, Hyperplasia, Lymphoid | | Iliac, Hyperplasia, Plasma Cell | 3 | Lumbar, Hyperplasia, Lymphoid | 3 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7| DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4| | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lumbar, Hyperplasia, Plasma Cell | 2 | Mediastinal, Hyperplasia, Lymphoid | 3 | Mediastinal, Hyperplasia, Plasma Cell| 2 | Renal, Hyperplasia, Lymphoid | 3 | Renal, Hyperplasia, Plasma Cell | 2 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | Hemorrhage | 4 | Hyperplasia, Lymphoid | 2 1 2 | Hyperplasia, Plasma Cell | | Inflammation, Acute | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + M + +| Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 3 3 | Necrosis | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 3 | Hematopoietic Cell Proliferation | 3 2 2 2 1 2 2| Hyperplasia, Lymphoid | 2 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| Cyst | 2 | Depletion Lymphoid | 3 | Hyperplasia, Lymphoid | 3 | Necrosis | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | | Inflammation, Chronic Active, Focal | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 2 1 2 1 2 2 2 2 1 2 2 2 2 2 1 1 | Necrosis, Focal | 3 | Artery, Inflammation, Chronic, Focal | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Hemorrhage, Focal | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7| DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4| | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Infiltration Cellular, Focal, | | Lymphocyte | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Arteriole, Inflammation, Chronic, | | Focal | 2 | __________________________________________________________________________| Eye | +| Cornea, Inflammation, Chronic | 2| __________________________________________________________________________| Harderian Gland | +| __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + M + + M + + M M + + + +| Inflammation, Acute, Focal | | Duct, Dilatation | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Lymphocyte | | Metaplasia, Focal, Osseous | 1 | Nephropathy | 1 | Artery, Inflammation, Chronic, Focal | 3 | Glomerulus, Inflammation, Chronic | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 4 | Arteriole, Inflammation, Chronic, | | Focal | 2 | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4| | 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + M + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Basophilic Focus | X X X| Clear Cell Focus | | Cyst | X | Eosinophilic Focus | X X X X X X | Fatty Change, Focal | | Infiltration Cellular, Histiocyte | | Inflammation, Chronic, Focal | | Mixed Cell Focus | | Necrosis, Focal | 1 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis, Focal | 2 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Infiltration Cellular, Focal, | | Lymphocyte | 2 | Inflammation, Chronic Active, Focal | 2 | Acinar Cell, Hypertrophy, Focal | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Arteriole, Inflammation, Chronic, | | Multifocal | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Arteriole, Inflammation, Chronic, | | Focal | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Hyperplasia, Focal | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4| | 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Congestion | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | __________________________________________________________________________| Parathyroid Gland | M + + M + + + M + + + M + + + M + M + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis, Focal | 1 | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia, Focal | 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Lymphocyte | 2 1 | Arteriole, Inflammation, Chronic, | | Focal | | Follicle, Dilatation, Focal | 2 | Follicular Cell, Hyperplasia, Focal | 2 2 2 2 2 2 3| Follicular Cell, Hypertrophy, Focal | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | Inflammation, Chronic Active | | __________________________________________________________________________| Ovary | + + + + + + + + + + A + + + + + + + + + M + + +| Abscess | 3 2 | Cyst | X X X X X X X X X| Hemorrhage, Focal | | Inflammation, Chronic, Focal | 4 | Bilateral, Abscess | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 3 3 2 2 3 3 | Inflammation, Acute | | Inflammation, Chronic Active | 3 | Endometrium, Hyperplasia, Cystic | 2 3 2 2 3 2 3 2 3 2 2 3 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hyperplasia, Lymphoid | 2 | Hyperplasia | 2 3 | __________________________________________________________________________| Lymph Node | + + + | Iliac, Hyperplasia, Lymphoid | 3 | Iliac, Hyperplasia, Plasma Cell | | Lumbar, Hyperplasia, Lymphoid | 3 3 | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4| | 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lumbar, Hyperplasia, Plasma Cell | | Mediastinal, Hyperplasia, Lymphoid | | Mediastinal, Hyperplasia, Plasma Cell| | Renal, Hyperplasia, Lymphoid | 2 | Renal, Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hemorrhage | | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 2| Inflammation, Acute | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | 2 2 | Necrosis | | __________________________________________________________________________| Spleen | + + + + + + + + + + A + + + + + + + + + + + + +| Depletion Lymphoid | | Hematopoietic Cell Proliferation | 2 2 3 | Hyperplasia, Lymphoid | 3 2 1 3 | __________________________________________________________________________| Thymus | + + + + M + + + M + + + + + + + + + + + + + + +| Cyst | | Depletion Lymphoid | | Hyperplasia, Lymphoid | | Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | 2 | Inflammation, Chronic Active, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 1 2 1 2 1 2 1 1 1 1 1 2 2| Necrosis, Focal | | Artery, Inflammation, Chronic, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage, Focal | 2 | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4| | 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Infiltration Cellular, Focal, | | Lymphocyte | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Arteriole, Inflammation, Chronic, | | Focal | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic | 2 | __________________________________________________________________________| Harderian Gland | + + | __________________________________________________________________________| Zymbal's Gland | + + + + M + + + M M + + + M + + + + + + + + + +| Inflammation, Acute, Focal | 2 | Duct, Dilatation | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Lymphocyte | 2 | Metaplasia, Focal, Osseous | 2 | Nephropathy | 1 2 3 | Artery, Inflammation, Chronic, Focal | | Glomerulus, Inflammation, Chronic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + +| Inflammation, Acute | | Arteriole, Inflammation, Chronic, | | Focal | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 49 | __________________________________________________________________________|____________| Gallbladder | | 47 | __________________________________________________________________________|____________| Intestine Large, Colon | | 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 46 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | | 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 48 | __________________________________________________________________________|____________| Liver | | 49 | Angiectasis, Focal | | 4 2.0| Basophilic Focus | | 4 | Clear Cell Focus | | 2 | Cyst | | 1 | Eosinophilic Focus | | 11 | Fatty Change, Focal | | 1 3.0| Infiltration Cellular, Histiocyte | | 1 2.0| Inflammation, Chronic, Focal | | 1 2.0| Mixed Cell Focus | | 1 | Necrosis, Focal | | 2 1.0| __________________________________________________________________________|____________| Mesentery | | 6 | Fat, Necrosis, Focal | | 6 2.2| __________________________________________________________________________|____________| Pancreas | | 49 | Accessory Spleen | | 1 | Infiltration Cellular, Focal, | | | Lymphocyte | | 1 2.0| Inflammation, Chronic Active, Focal | | 2 2.0| Acinar Cell, Hypertrophy, Focal | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | | 49 | Arteriole, Inflammation, Chronic, | | | Multifocal | | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | | 49 | __________________________________________________________________________|____________| Stomach, Glandular | | 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 49 | Arteriole, Inflammation, Chronic, | | | Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 49 | Cyst | | 1 | Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | | 49 | Congestion | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 49 | Hyperplasia, Focal | | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | | 33 | __________________________________________________________________________|____________| Pituitary Gland | | 48 | Pars Distalis, Angiectasis, Focal | | 2 1.5| Pars Distalis, Cyst | | 1 | Pars Distalis, Hyperplasia, Focal | | 6 1.8| __________________________________________________________________________|____________| Thyroid Gland | | 49 | Infiltration Cellular, Focal, | | | Lymphocyte | | 2 1.5| Arteriole, Inflammation, Chronic, | | | Focal | | 1 3.0| Follicle, Dilatation, Focal | | 2 2.0| Follicular Cell, Hyperplasia, Focal | | 11 1.9| Follicular Cell, Hypertrophy, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Ovary | | 47 | Abscess | | 2 2.5| Cyst | | 12 1.0| Hemorrhage, Focal | | 1 2.0| Inflammation, Chronic, Focal | | 2 4.0| Bilateral, Abscess | | 1 3.0| __________________________________________________________________________|____________| Uterus | | 49 | Dilatation | | 13 2.6| Inflammation, Acute | | 1 2.0| Inflammation, Chronic Active | | 2 2.5| Endometrium, Hyperplasia, Cystic | | 31 2.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 49 | Congestion | | 1 3.0| Hyperplasia, Lymphoid | | 1 2.0| Hyperplasia | | 5 2.6| __________________________________________________________________________|____________| Lymph Node | | 9 | Iliac, Hyperplasia, Lymphoid | | 1 3.0| Iliac, Hyperplasia, Plasma Cell | | 1 3.0| Lumbar, Hyperplasia, Lymphoid | | 3 3.0| Lumbar, Hyperplasia, Plasma Cell | | 1 2.0| Mediastinal, Hyperplasia, Lymphoid | | 1 3.0| Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0| Renal, Hyperplasia, Lymphoid | | 2 2.5| Renal, Hyperplasia, Plasma Cell | | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 49 | Cyst | | 2 | Hemorrhage | | 1 4.0| Hyperplasia, Lymphoid | | 3 1.7| Hyperplasia, Plasma Cell | | 1 2.0| Inflammation, Acute | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 46 | Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 5 2.4| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Spleen | | 48 | Depletion Lymphoid | | 1 3.0| Hematopoietic Cell Proliferation | | 10 2.1| Hyperplasia, Lymphoid | | 6 2.3| __________________________________________________________________________|____________| Thymus | | 46 | Cyst | | 1 2.0| Depletion Lymphoid | | 1 3.0| Hyperplasia, Lymphoid | | 1 3.0| Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 49 | __________________________________________________________________________|____________| Skin | | 49 | Inflammation, Acute, Focal | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Inflammation, Chronic Active, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 49 | Mineralization, Focal | | 29 1.6| Necrosis, Focal | | 1 3.0| Artery, Inflammation, Chronic, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 49 | Congestion | | 1 2.0| Hemorrhage, Focal | | 1 2.0| Infiltration Cellular, Focal, | | | Lymphocyte | | 1 2.0| __________________________________________________________________________|____________| Nose | | 49 | __________________________________________________________________________|____________| Trachea | | 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | Arteriole, Inflammation, Chronic, | | | Focal | | 1 2.0| __________________________________________________________________________|____________| Eye | | 2 | Cornea, Inflammation, Chronic | | 2 2.0| __________________________________________________________________________|____________| Harderian Gland | | 3 | __________________________________________________________________________|____________| Zymbal's Gland | | 38 | Inflammation, Acute, Focal | | 1 2.0| Duct, Dilatation | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 49 | Infiltration Cellular, Focal, | | | Lymphocyte | | 1 2.0| Metaplasia, Focal, Osseous | | 2 1.5| Nephropathy | | 4 1.8| Artery, Inflammation, Chronic, Focal | | 1 3.0| Glomerulus, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | | 48 | Inflammation, Acute | | 1 4.0| Arteriole, Inflammation, Chronic, | | | Focal | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + M + + + + + + + + + + M +| Dilatation | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 4| Intussusception | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 2 | Basophilic Focus | X X | Clear Cell Focus | X | Eosinophilic Focus | X X X| Fatty Change, Focal | | Infiltration Cellular, Focal, | | Lymphocyte | 2| Mixed Cell Focus | X | Necrosis, Focal | 1 | Centrilobular, Cytomegaly | 3 | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis, Focal | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Inflammation, Chronic Active, Focal | 3 | Duct, Dilatation | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer, Focal | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +| Cytoplasmic Alteration, Focal | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia, Focal | 2| _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + + M + + + M + M + + + + + + + + M +| Infiltration Cellular, Focal, | | Lymphocyte | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia, Focal | 2 1 2 2 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Focal | 1 | Follicular Cell, Hyperplasia, Focal | 1 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X X X X X X X X | Hematocyst | X | Infiltration Cellular, Focal, | | Lymphocyte | 3 | Mineralization, Focal | 2 | Pigmentation, Focal | 3 | Follicle, Hyperplasia, Cystic, Focal | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 4 3 4 4 3 4| Thrombosis, Focal | 3 | Endometrium, Hyperplasia, Cystic | 2 3 4 3 3 3 2 1 1 3 2 2 2 2 2 3 3 3 3 3 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + | Lumbar, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + M + + + + + + +| Congestion | 1 | Cyst | | Edema | | Hyperplasia, Lymphoid | 2 3 2 | Hyperplasia, Plasma Cell | 3 | Infiltration Cellular, Mast Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | Hemorrhage | 2 | Hyperplasia, Lymphoid | 3 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 3 2 2 3 2| Hyperplasia, Lymphoid | 2 2 3 3 | __________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| Cyst | X| Hemorrhage, Focal | 2 | Hyperplasia, Lymphoid | 2 2 | Necrosis | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis, Focal | 2 | Inflammation, Chronic Active, Focal | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | Intervertebral Disc, Dysplasia, Focal| 2 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Hydrocephalus | 2 | Mineralization, Focal | 1 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 1 2 2 1 2| __________________________________________________________________________| Spinal Cord | + | Infiltration Cellular, Focal, | | Histiocyte | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | 3 | Infiltration Cellular, Focal, | | Histiocyte | 2 | Interstitium, Inflammation, Focal | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Pinna, Inflammation, Chronic Active, | | Focal | 3 | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Lens, Cataract | 2 | __________________________________________________________________________| Zymbal's Gland | + I + + M + + + + M M + M M + + + + + + + + + M +| Duct, Dilatation | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Lymphocyte | 3 | Metaplasia, Focal, Osseous | | Nephropathy | 3 | Glomerulus, Inflammation, Chronic | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4| | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + + + + + + + + + + + + + + + M + + + M +| Dilatation | 3 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | Intussusception | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 1 | Basophilic Focus | | Clear Cell Focus | X | Eosinophilic Focus | X X X X | Fatty Change, Focal | 1 | Infiltration Cellular, Focal, | | Lymphocyte | 2 | Mixed Cell Focus | | Necrosis, Focal | | Centrilobular, Cytomegaly | | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis, Focal | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | | Inflammation, Chronic Active, Focal | | Duct, Dilatation | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer, Focal | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4| | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + M + M M M M + M + + + + M + M M + + + M| Infiltration Cellular, Focal, | | Lymphocyte | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia, Focal | 2 1 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Focal | | Follicular Cell, Hyperplasia, Focal | 2 2 4 2 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X 1 X X X X X X | Hematocyst | | Infiltration Cellular, Focal, | | Lymphocyte | | Mineralization, Focal | | Pigmentation, Focal | | Follicle, Hyperplasia, Cystic, Focal | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 3 3 3 4 | Thrombosis, Focal | | Endometrium, Hyperplasia, Cystic | 2 3 3 2 3 4 4 2 2 3 3 2 3 2 2 2 2 3 2 2 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + | Lumbar, Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Cyst | X X X | Edema | 2 | Hyperplasia, Lymphoid | 3 1 2 1 | Hyperplasia, Plasma Cell | 3 | Infiltration Cellular, Mast Cell | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + M + + + + +| Angiectasis, Focal | 2 | Hemorrhage | | Hyperplasia, Lymphoid | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4| | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 2 2 2 2 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| Cyst | X| Hemorrhage, Focal | | Hyperplasia, Lymphoid | 2 | Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis, Focal | | Inflammation, Chronic Active, Focal | 3 3 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 | Intervertebral Disc, Dysplasia, Focal| | __________________________________________________________________________| Skeletal Muscle | + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | 1 | Hydrocephalus | | Mineralization, Focal | 2 2 2 1 2 2 1 2 2 1 2 2 2 2 2 2 1 2 2 1 2 2 2 2| __________________________________________________________________________| Spinal Cord | | Infiltration Cellular, Focal, | | Histiocyte | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Infiltration Cellular, Focal, | | Histiocyte | 2 | Interstitium, Inflammation, Focal | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Pinna, Inflammation, Chronic Active, | | Focal | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4| | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Lens, Cataract | | __________________________________________________________________________| Zymbal's Gland | + + + + M + + M + + + + + M + + + + + M M + + + +| Duct, Dilatation | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Lymphocyte | 2 | Metaplasia, Focal, Osseous | 2 | Nephropathy | 1 1| Glomerulus, Inflammation, Chronic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Gallbladder | | 45 | Dilatation | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 50 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | | 50 | Hyperplasia, Lymphoid | | 1 4.0| Intussusception | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 50 | __________________________________________________________________________|____________| Liver | | 50 | Angiectasis, Focal | | 3 1.7| Basophilic Focus | | 2 | Clear Cell Focus | | 2 | Eosinophilic Focus | | 7 | Fatty Change, Focal | | 1 1.0| Infiltration Cellular, Focal, | | | Lymphocyte | | 2 2.0| Mixed Cell Focus | | 1 | Necrosis, Focal | | 1 1.0| Centrilobular, Cytomegaly | | 1 3.0| __________________________________________________________________________|____________| Mesentery | | 5 | Fat, Necrosis, Focal | | 2 2.0| __________________________________________________________________________|____________| Pancreas | | 50 | Accessory Spleen | | 1 | Inflammation, Chronic Active, Focal | | 1 3.0| Duct, Dilatation | | 2 2.5| __________________________________________________________________________|____________| Salivary Glands | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | Ulcer, Focal | | 2 2.5| __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Inflammation, Acute, Focal | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Cardiomyopathy | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 49 | Cytoplasmic Alteration, Focal | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | | 49 | Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 34 | Infiltration Cellular, Focal, | | | Lymphocyte | | 1 3.0| __________________________________________________________________________|____________| Pituitary Gland | | 50 | Pars Distalis, Cyst | | 1 | Pars Distalis, Hyperplasia, Focal | | 11 1.7| __________________________________________________________________________|____________| Thyroid Gland | | 50 | C-Cell, Hyperplasia, Focal | | 1 1.0| Follicular Cell, Hyperplasia, Focal | | 9 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | | 50 | Cyst | | 17 1.0| Hematocyst | | 1 | Infiltration Cellular, Focal, | | | Lymphocyte | | 1 3.0| Mineralization, Focal | | 1 2.0| Pigmentation, Focal | | 1 3.0| Follicle, Hyperplasia, Cystic, Focal | | 1 3.0| __________________________________________________________________________|____________| Uterus | | 50 | Dilatation | | 12 3.4| Thrombosis, Focal | | 1 3.0| Endometrium, Hyperplasia, Cystic | | 42 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | __________________________________________________________________________|____________| Lymph Node | | 10 | Lumbar, Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 48 | Congestion | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Cyst | | 3 | Edema | | 1 2.0| Hyperplasia, Lymphoid | | 7 2.0| Hyperplasia, Plasma Cell | | 2 3.0| Infiltration Cellular, Mast Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 48 | Angiectasis, Focal | | 1 2.0| Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 2 2.5| __________________________________________________________________________|____________| Spleen | | 50 | Hematopoietic Cell Proliferation | | 9 2.2| Hyperplasia, Lymphoid | | 5 2.4| __________________________________________________________________________|____________| Thymus | | 48 | Cyst | | 2 | Hemorrhage, Focal | | 1 2.0| Hyperplasia, Lymphoid | | 3 2.0| Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 49 | __________________________________________________________________________|____________| Skin | | 50 | Acanthosis, Focal | | 1 2.0| Inflammation, Chronic Active, Focal | | 4 2.8| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 50 | Fibrous Osteodystrophy | | 1 3.0| Intervertebral Disc, Dysplasia, Focal| | 1 2.0| __________________________________________________________________________|____________| Skeletal Muscle | | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Hemorrhage, Focal | | 1 1.0| Hydrocephalus | | 1 2.0| Mineralization, Focal | | 45 1.8| __________________________________________________________________________|____________| Spinal Cord | | 1 | Infiltration Cellular, Focal, | | | Histiocyte | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Hemorrhage, Focal | | 1 3.0| Infiltration Cellular, Focal, | | | Histiocyte | | 2 2.0| Interstitium, Inflammation, Focal | | 1 2.0| __________________________________________________________________________|____________| Nose | | 50 | Inflammation, Acute, Focal | | 2 1.5| __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | Pinna, Inflammation, Chronic Active, | | | Focal | | 1 3.0| __________________________________________________________________________|____________| Eye | | 1 | Lens, Cataract | | 1 2.0| __________________________________________________________________________|____________| Zymbal's Gland | | 38 | Duct, Dilatation | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Infiltration Cellular, Focal, | | | Lymphocyte | | 2 2.5| Metaplasia, Focal, Osseous | | 1 2.0| Nephropathy | | 3 1.7| Glomerulus, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | | 50 | Dilatation | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + I + + + + + + + + + + + +| Dilatation | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X | Eosinophilic Focus | X X X X | Fatty Change, Focal | 3 | Infiltration Cellular, Focal, | | Lymphocyte | | __________________________________________________________________________| Mesentery | + | Fat, Necrosis, Focal | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +| Hyperplasia, Focal | | Ulcer, Focal | 2| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + A + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 3 1 | Degeneration, Focal | | Hemorrhage, Focal | 2 2 1 2 | Hypertrophy, Focal | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + A + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + M + M M + M + + A + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia, Focal | 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | 2 | Follicle, Dilatation, Focal | 4 | Follicular Cell, Hyperplasia, Focal | 2 2 1 | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + A + + + + + + + + + + + +| Angiectasis | | Cyst | X X X X X X X| Hematocyst | X X | Mineralization, Focal | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 3 4 4 4 3 | Ectopic Tissue, Focal | | Endometrium, Hyperplasia, Cystic | 3 3 2 1 4 3 2 2 3 3 2 2 2 2 2 4 3 3 3 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + | Lumbar, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + A + + + + + + + + + + + +| Cyst | X | Hemorrhage | | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + I + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition, Focal | | Hematopoietic Cell Proliferation | 3 | Hyperplasia, Lymphoid | 2 2 1 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + A + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | | Inflammation, Chronic Active, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage, Focal | | Arteriole, Hypertrophy, Focal | | Interstitium, Inflammation, Focal | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Lens, Cataract | | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | + M + + + + + + + + + M + + M M + + + + M + + M M| Inflammation, Acute, Focal | 2 | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct, Chronic, Focal | 3 | Infiltration Cellular, Focal, | | Lymphocyte | | Nephropathy | 1 2 | Renal Tubule, Dilatation, Focal | 4 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +| Dilatation | | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M M + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X | Clear Cell Focus | | Eosinophilic Focus | X X X X X X X| Fatty Change, Focal | | Infiltration Cellular, Focal, | | Lymphocyte | 3 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis, Focal | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Ulcer, Focal | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 | Degeneration, Focal | 2 | Hemorrhage, Focal | 2 2 3 | Hypertrophy, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + M + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia, Focal | 2 2 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | | Follicle, Dilatation, Focal | | Follicular Cell, Hyperplasia, Focal | 2 1 2 3 | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Cyst | X X X X X X X X | Hematocyst | X | Mineralization, Focal | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 4 3 4 3 3 3 3 3 | Ectopic Tissue, Focal | X | Endometrium, Hyperplasia, Cystic | 3 4 1 3 2 2 2 2 2 2 3 2 3 1 3 1 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + | Lumbar, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Hemorrhage | 3 | Hyperplasia, Lymphoid | 3 3 3 | Hyperplasia, Plasma Cell | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition, Focal | 2 | Hematopoietic Cell Proliferation | 2 2 | Hyperplasia, Lymphoid | 2 2 2 2 2 1 2| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | 3 | Inflammation, Chronic Active, Focal | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 1 2 2 2 2 1 1 1 2 2 1 2 2 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Hemorrhage, Focal | 2 | Arteriole, Hypertrophy, Focal | 2 | Interstitium, Inflammation, Focal | 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Lens, Cataract | 2 | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | M + M + + M M + + + + + + + + M + + + + + + + +| Inflammation, Acute, Focal | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Infarct, Chronic, Focal | | Infiltration Cellular, Focal, | | Lymphocyte | 3 3 | Nephropathy | 1 1 1 | Renal Tubule, Dilatation, Focal | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 49 | __________________________________________________________________________|____________| Gallbladder | | 46 | Dilatation | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | | 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 48 | __________________________________________________________________________|____________| Liver | | 49 | Basophilic Focus | | 6 | Clear Cell Focus | | 1 | Eosinophilic Focus | | 11 | Fatty Change, Focal | | 1 3.0| Infiltration Cellular, Focal, | | | Lymphocyte | | 1 3.0| __________________________________________________________________________|____________| Mesentery | | 3 | Fat, Necrosis, Focal | | 3 2.0| __________________________________________________________________________|____________| Pancreas | | 48 | __________________________________________________________________________|____________| Salivary Glands | | 49 | __________________________________________________________________________|____________| Stomach, Forestomach | | 48 | Hyperplasia, Focal | | 1 2.0| Ulcer, Focal | | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | | 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 48 | Cytoplasmic Alteration, Focal | | 4 2.0| Degeneration, Focal | | 1 2.0| Hemorrhage, Focal | | 7 2.0| Hypertrophy, Focal | | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | | 48 | Hyperplasia, Focal | | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 48 | __________________________________________________________________________|____________| Parathyroid Gland | | 40 | __________________________________________________________________________|____________| Pituitary Gland | | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Hyperplasia, Focal | | 7 1.9| __________________________________________________________________________|____________| Thyroid Gland | | 49 | Inflammation, Chronic Active, Focal | | 1 2.0| Follicle, Dilatation, Focal | | 1 4.0| Follicular Cell, Hyperplasia, Focal | | 7 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | | 48 | Angiectasis | | 1 3.0| Cyst | | 15 | Hematocyst | | 3 | Mineralization, Focal | | 1 3.0| __________________________________________________________________________|____________| Uterus | | 49 | Dilatation | | 15 3.4| Ectopic Tissue, Focal | | 1 | Endometrium, Hyperplasia, Cystic | | 38 2.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 49 | __________________________________________________________________________|____________| Lymph Node | | 8 | Lumbar, Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 48 | Cyst | | 2 | Hemorrhage | | 1 3.0| Hyperplasia, Lymphoid | | 4 2.8| Hyperplasia, Plasma Cell | | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 47 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Spleen | | 49 | Amyloid Deposition, Focal | | 1 2.0| Hematopoietic Cell Proliferation | | 3 2.3| Hyperplasia, Lymphoid | | 10 1.8| __________________________________________________________________________|____________| Thymus | | 48 | Hyperplasia, Lymphoid | | 2 2.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 49 | __________________________________________________________________________|____________| Skin | | 49 | Inflammation, Acute, Focal | | 1 3.0| Inflammation, Chronic Active, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 49 | Mineralization, Focal | | 34 1.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 49 | Congestion | | 1 2.0| Hemorrhage, Focal | | 1 2.0| Arteriole, Hypertrophy, Focal | | 1 2.0| Interstitium, Inflammation, Focal | | 3 1.0| __________________________________________________________________________|____________| Nose | | 49 | Congestion | | 1 2.0| __________________________________________________________________________|____________| Trachea | | 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Lens, Cataract | | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | | 2 | __________________________________________________________________________|____________| Zymbal's Gland | | 37 | Inflammation, Acute, Focal | | 1 2.0| Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 49 | Infarct, Chronic, Focal | | 1 3.0| Infiltration Cellular, Focal, | | | Lymphocyte | | 2 3.0| Nephropathy | | 5 1.2| Renal Tubule, Dilatation, Focal | | 2 3.0| __________________________________________________________________________|____________| Urinary Bladder | | 48 | Dilatation | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 0| 4| 4| 4| 4| 4| | 9| 9| 9| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 0| 2| 1| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + A + + + + + + M + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + A + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X | Clear Cell Focus | X X X X X X X X | Eosinophilic Focus | X X X X X X X X X X | Fatty Change, Focal | 2 | Necrosis, Focal | 1 | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis, Focal | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis, Focal | | Acinar Cell, Atrophy | | Duct, Dilatation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 | Ulcer, Focal | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Cytoplasmic Alteration, Focal | 2 | Degeneration, Focal | 2 | Hemorrhage, Focal | 2 | Hypertrophy, Focal | 2 | Vacuolization Cytoplasmic, Focal | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| Degeneration, Focal | 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2 | __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + M + + + M M + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + + + M + + + +| Pars Distalis, Cyst | X | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 0| 4| 4| 4| 4| 4| | 9| 9| 9| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 0| 2| 1| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Hyperplasia, Focal | 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Focal | | Follicular Cell, Hyperplasia, Focal | 2 2 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | Inflammation, Chronic Active | | Duct, Dilatation | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | X X X 1 1 X X X X X X X X X| Ectopic Tissue | | Hematocyst | X | Hyperplasia, Tubular | | Infiltration Cellular, Focal, | | Lymphocyte | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 2 2 2 2 2 2 | Endometrium, Hyperplasia, Cystic | 2 4 2 2 2 3 2 2 2 3 2 2 2 1 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Hyperplasia | | __________________________________________________________________________| Lymph Node | + + + | Iliac, Hyperplasia, Plasma Cell | 2 | Mediastinal, Hyperplasia, Lymphoid | | Renal, Hyperplasia, Plasma Cell | 1 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Hyperplasia, Lymphoid | 2 3 | Hyperplasia, Plasma Cell | 1 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + M +| Hemorrhage | | Hyperplasia, Lymphoid | 1 | Hyperplasia, Plasma Cell | 2 | Necrosis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Hematopoietic Cell Proliferation | 2 2 3 | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 0| 4| 4| 4| 4| 4| | 9| 9| 9| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 0| 2| 1| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia, Lymphoid | 2 2 3 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| Atrophy | | Cyst | | Depletion Lymphoid | | Necrosis | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 1 2 2 2 2 2 2 1 2 2 2 2 1 1 2 2 2 2 2 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 1 | Hemorrhage, Multifocal | | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + M + + + + M M M + + + M + + M + + + + + + + M M| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct, Chronic, Focal | | Infiltration Cellular, Focal, | | Lymphocyte | 3 | Metaplasia, Focal, Osseous | 2 | Nephropathy | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 2| 4| 4| 4| 4| 8| 4| 4| 4| 0| 4| 4| 4| 4| 1| 4| 3| 2| 9| 4| 4| 4| 3| 4| 4| | 7| 2| 2| 2| 2| 9| 2| 2| 2| 8| 2| 2| 2| 2| 5| 2| 8| 1| 4| 2| 2| 2| 9| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + M + + + + + M + + + + + + M + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | X X X X | Eosinophilic Focus | X X X X X X X X X X X | Fatty Change, Focal | 2 | Necrosis, Focal | 2 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis, Focal | 4 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis, Focal | 3 | Acinar Cell, Atrophy | 3 3 | Duct, Dilatation | 3 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Ulcer, Focal | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + M + + + + + + + + + + + + + + + + + + + + +| Cyst | X X X | Cytoplasmic Alteration, Focal | | Degeneration, Focal | | Hemorrhage, Focal | | Hypertrophy, Focal | | Vacuolization Cytoplasmic, Focal | | __________________________________________________________________________| Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + +| Degeneration, Focal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Parathyroid Gland | + + M + M + M + + + + + + + + + M + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + M + + + + + + M + + + + + + + + + + + + + +| Pars Distalis, Cyst | | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 2| 4| 4| 4| 4| 8| 4| 4| 4| 0| 4| 4| 4| 4| 1| 4| 3| 2| 9| 4| 4| 4| 3| 4| 4| | 7| 2| 2| 2| 2| 9| 2| 2| 2| 8| 2| 2| 2| 2| 5| 2| 8| 1| 4| 2| 2| 2| 9| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Hyperplasia, Focal | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Focal | 1| Follicular Cell, Hyperplasia, Focal | 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | Inflammation, Chronic Active | 2 | Duct, Dilatation | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 2 | Cyst | X X X X X X X X X X X X 1 1| Ectopic Tissue | X | Hematocyst | X | Hyperplasia, Tubular | 2 | Infiltration Cellular, Focal, | | Lymphocyte | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 3| Endometrium, Hyperplasia, Cystic | 1 2 2 3 3 3 2 3 2 2 3 2 2 2 1 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | Hyperplasia | 3 3 | __________________________________________________________________________| Lymph Node | + + + + | Iliac, Hyperplasia, Plasma Cell | | Mediastinal, Hyperplasia, Lymphoid | 2 | Renal, Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + M + + + + + + + + + + + + + +| Cyst | X X | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + +| Hemorrhage | 2 | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | | Necrosis | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 | Hematopoietic Cell Proliferation | 3 2 2 | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 2| 4| 4| 4| 4| 8| 4| 4| 4| 0| 4| 4| 4| 4| 1| 4| 3| 2| 9| 4| 4| 4| 3| 4| 4| | 7| 2| 2| 2| 2| 9| 2| 2| 2| 8| 2| 2| 2| 2| 5| 2| 8| 1| 4| 2| 2| 2| 9| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + + + + M + + + + + +| Atrophy | 3 | Cyst | X | Depletion Lymphoid | 3 | Necrosis | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 2 2 2 1 2 2 2 2 2 2 2 3 2 1 2 1 2 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage, Multifocal | 2 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + + M + + + + + + M + + + M + M + + M M +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Infarct, Chronic, Focal | 2 | Infiltration Cellular, Focal, | | Lymphocyte | | Metaplasia, Focal, Osseous | 1 | Nephropathy | 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | 3 2 | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 48 | __________________________________________________________________________|____________| Gallbladder | | 42 | __________________________________________________________________________|____________| Intestine Large, Colon | | 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 45 | __________________________________________________________________________|____________| Liver | | 49 | Basophilic Focus | | 7 | Clear Cell Focus | | 12 | Eosinophilic Focus | | 21 | Fatty Change, Focal | | 2 2.0| Necrosis, Focal | | 2 1.5| __________________________________________________________________________|____________| Mesentery | | 5 | Fat, Necrosis, Focal | | 3 3.0| __________________________________________________________________________|____________| Pancreas | | 49 | Fibrosis, Focal | | 1 3.0| Acinar Cell, Atrophy | | 2 3.0| Duct, Dilatation | | 2 3.0| __________________________________________________________________________|____________| Salivary Glands | | 48 | __________________________________________________________________________|____________| Stomach, Forestomach | | 49 | Hyperplasia, Focal | | 2 1.5| Ulcer, Focal | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | | 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 48 | Cyst | | 3 | Cytoplasmic Alteration, Focal | | 1 2.0| Degeneration, Focal | | 1 2.0| Hemorrhage, Focal | | 1 2.0| Hypertrophy, Focal | | 1 2.0| Vacuolization Cytoplasmic, Focal | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | | 47 | Degeneration, Focal | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | | 49 | Hyperplasia, Focal | | 2 2.0| __________________________________________________________________________|____________| Parathyroid Gland | | 40 | __________________________________________________________________________|____________| Pituitary Gland | | 45 | Pars Distalis, Cyst | | 1 | Pars Distalis, Hyperplasia, Focal | | 3 1.3| __________________________________________________________________________|____________| Thyroid Gland | | 49 | C-Cell, Hyperplasia, Focal | | 1 1.0| Follicular Cell, Hyperplasia, Focal | | 6 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | Inflammation, Chronic Active | | 1 2.0| Duct, Dilatation | | 1 2.0| __________________________________________________________________________|____________| Ovary | | 49 | Angiectasis | | 3 2.3| Cyst | | 28 1.0| Ectopic Tissue | | 1 | Hematocyst | | 2 | Hyperplasia, Tubular | | 1 2.0| Infiltration Cellular, Focal, | | | Lymphocyte | | 1 3.0| __________________________________________________________________________|____________| Uterus | | 49 | Dilatation | | 9 2.3| Endometrium, Hyperplasia, Cystic | | 31 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 49 | Angiectasis, Focal | | 1 2.0| Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Lymph Node | | 7 | Iliac, Hyperplasia, Plasma Cell | | 1 2.0| Mediastinal, Hyperplasia, Lymphoid | | 1 2.0| Renal, Hyperplasia, Plasma Cell | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 47 | Cyst | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia, Lymphoid | | 2 2.5| Hyperplasia, Plasma Cell | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 46 | Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 1 1.0| Hyperplasia, Plasma Cell | | 1 2.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Spleen | | 49 | Depletion Lymphoid | | 1 2.0| Hematopoietic Cell Proliferation | | 6 2.3| Hyperplasia, Lymphoid | | 5 2.2| __________________________________________________________________________|____________| Thymus | | 46 | Atrophy | | 1 3.0| Cyst | | 1 | Depletion Lymphoid | | 1 3.0| Necrosis | | 2 2.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 48 | __________________________________________________________________________|____________| Skin | | 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 49 | Mineralization, Focal | | 38 1.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 49 | Congestion | | 1 1.0| Hemorrhage, Multifocal | | 1 2.0| Alveolar Epithelium, Hyperplasia, | | | Focal | | 2 2.0| __________________________________________________________________________|____________| Nose | | 49 | __________________________________________________________________________|____________| Trachea | | 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 32 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 49 | Infarct, Chronic, Focal | | 1 2.0| Infiltration Cellular, Focal, | | | Lymphocyte | | 1 3.0| Metaplasia, Focal, Osseous | | 2 1.5| Nephropathy | | 3 1.7| __________________________________________________________________________|____________| Urinary Bladder | | 49 | Inflammation, Chronic Active, Focal | | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 1| 1| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 3| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + M + + + + M + + + + + + + + M M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X| Clear Cell Focus | X X | Developmental Malformation | X | Eosinophilic Focus | X X X X X | Infarct, Chronic | | Inflammation, Chronic, Focal | 2 | Leukocytosis | | Mixed Cell Focus | X | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis, Focal | 2 1 2 | __________________________________________________________________________| Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Inflammation, Chronic Active, Focal | | Ulcer, Focal | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | Hypertrophy, Focal | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | __________________________________________________________________________| Parathyroid Gland | M + + + + M M + M + + + + + + + M M + + + + + + +| Inflammation, Chronic, Focal | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| Pars Distalis, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia, Focal | 2 2 | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 1| 1| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 3| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | Inflammation, Chronic, Focal | 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | Duct, Dilatation | 3 3 3 3 2 3 3 3 3 4 3 3 2 3 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 | Inflammation, Acute | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Focal | 3 | Seminiferous Tubule, Degeneration, | | Focal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lymph Node | + | Bronchial, Hyperplasia, Lymphoid | | Renal, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + M + M + + + + + + + + + + + + + + + + M +| Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + A + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | 4 | Hyperplasia, Plasma Cell | | Necrosis | 2 | __________________________________________________________________________| Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | Hyperplasia, Lymphoid | 3 | Lymphocyte, Necrosis, Focal | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| Cyst | X | Necrosis | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M + M M M M M M M M M M M M M I M M I I M M| _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 1| 1| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 3| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | 2 | Mineralization, Focal | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukocytosis | | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | Interstitium, Inflammation, Focal | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Middle Ear, Inflammation, Chronic | | Active, Focal | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + M + + M + + + + + + + + + M M| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 1 2 1 1 1 1 2 2 2| Renal Tubule, Dilatation, Focal | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | Transitional Epithelium, Hyperplasia,| | Focal | 2 | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | X X X X X X | Developmental Malformation | | Eosinophilic Focus | X X X X X X X X | Infarct, Chronic | 3 | Inflammation, Chronic, Focal | | Leukocytosis | 2 | Mixed Cell Focus | X X | __________________________________________________________________________| Mesentery | | Fat, Necrosis, Focal | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Inflammation, Chronic Active, Focal | 2 | Ulcer, Focal | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Hypertrophy, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + + M + + + + + M +| Inflammation, Chronic, Focal | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia, Focal | 2 | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 3 | Inflammation, Chronic, Focal | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + | Inflammation, Chronic Active | 3 3 | Duct, Dilatation | 3 2 3 2 3 2 3 3 3 4 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 1 | Inflammation, Acute | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Focal | | Seminiferous Tubule, Degeneration, | | Focal | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Lymph Node | + + + | Bronchial, Hyperplasia, Lymphoid | 2 | Renal, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2 3 | Hyperplasia, Lymphoid | 3 | Hyperplasia, Plasma Cell | 2 | Necrosis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 | Hyperplasia, Lymphoid | 2 | Lymphocyte, Necrosis, Focal | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Mineralization, Focal | 2 1 2 2 1 2 2 2 1 2 2 2 2 2 2 2 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukocytosis | 3 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 2 1 2 | Interstitium, Inflammation, Focal | 2 1 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Middle Ear, Inflammation, Chronic | | Active, Focal | 3 | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | + + M + + + + + + + + + M + + M + + M + + + M +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 1 2 1 1 1 1 2 2 1 1 1 1 3 1 | Renal Tubule, Dilatation, Focal | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Transitional Epithelium, Hyperplasia,| | Focal | | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 49 | __________________________________________________________________________|____________| Gallbladder | | 45 | __________________________________________________________________________|____________| Intestine Large, Colon | | 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 49 | __________________________________________________________________________|____________| Liver | | 50 | Basophilic Focus | | 7 | Clear Cell Focus | | 8 | Developmental Malformation | | 1 | Eosinophilic Focus | | 13 | Infarct, Chronic | | 1 3.0| Inflammation, Chronic, Focal | | 1 2.0| Leukocytosis | | 1 2.0| Mixed Cell Focus | | 3 | __________________________________________________________________________|____________| Mesentery | | 3 | Fat, Necrosis, Focal | | 3 1.7| __________________________________________________________________________|____________| Pancreas | | 49 | __________________________________________________________________________|____________| Salivary Glands | | 49 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | Hyperplasia, Focal | | 1 2.0| Inflammation, Chronic Active, Focal | | 1 2.0| Ulcer, Focal | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | | 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Cardiomyopathy | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 50 | Hyperplasia, Focal | | 1 3.0| Hypertrophy, Focal | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | | 50 | __________________________________________________________________________|____________| Islets, Pancreatic | | 49 | Hyperplasia, Focal | | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | | 41 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Inflammation, Chronic, Focal | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | | 49 | Pars Distalis, Cyst | | 1 | __________________________________________________________________________|____________| Thyroid Gland | | 50 | Follicular Cell, Hyperplasia, Focal | | 3 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 50 | Granuloma Sperm | | 2 2.5| Inflammation, Chronic, Focal | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | | 29 | Inflammation, Chronic Active | | 2 3.0| Duct, Dilatation | | 27 2.9| __________________________________________________________________________|____________| Prostate | | 50 | Hyperplasia, Focal | | 2 1.5| __________________________________________________________________________|____________| Seminal Vesicle | | 50 | Dilatation | | 2 1.5| Inflammation, Acute | | 1 2.0| __________________________________________________________________________|____________| Testes | | 50 | Degeneration, Focal | | 1 3.0| Seminiferous Tubule, Degeneration, | | | Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | | 4 | Bronchial, Hyperplasia, Lymphoid | | 1 2.0| Renal, Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 46 | Hyperplasia, Lymphoid | | 4 2.3| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 48 | Hemorrhage | | 3 2.3| Hyperplasia, Lymphoid | | 2 3.5| Hyperplasia, Plasma Cell | | 1 2.0| Necrosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | | 49 | Hematopoietic Cell Proliferation | | 3 2.7| Hyperplasia, Lymphoid | | 2 2.5| Lymphocyte, Necrosis, Focal | | 1 2.0| __________________________________________________________________________|____________| Thymus | | 49 | Cyst | | 2 | Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 1 | __________________________________________________________________________|____________| Skin | | 50 | Inflammation, Chronic Active, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Hemorrhage, Focal | | 1 2.0| Mineralization, Focal | | 36 1.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Leukocytosis | | 1 3.0| Alveolar Epithelium, Hyperplasia, | | | Focal | | 5 1.8| Interstitium, Inflammation, Focal | | 4 1.5| __________________________________________________________________________|____________| Nose | | 50 | Congestion | | 1 2.0| __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | Middle Ear, Inflammation, Chronic | | | Active, Focal | | 1 3.0| __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 3 | __________________________________________________________________________|____________| Zymbal's Gland | | 39 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Nephropathy | | 25 1.4| Renal Tubule, Dilatation, Focal | | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | | 50 | Dilatation | | 1 3.0| Transitional Epithelium, Hyperplasia,| | | Focal | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + A + + + + + + +| Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | Basophilic Focus | X X X | Clear Cell Focus | X X | Cytomegaly, Focal | | Eosinophilic Focus | X X X X| Fatty Change, Focal | | Hematopoietic Cell Proliferation | | Mixed Cell Focus | X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinar Cell, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | Ulcer, Focal | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | Hyperplasia, Focal | 3 2 | Hypertrophy, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X | Pars Nervosa, Cyst | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Hyperplasia, Focal | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 2 | Inflammation, Chronic, Focal | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + | Duct, Dilatation | 2 3 2 4 3 3 2 3 3 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 | Hyperplasia, Focal | 1 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | | Atrophy | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | Hyperplasia | | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | 2 1 3 | Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | X | Hematopoietic Cell Proliferation | | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M M + + + + + + + M + + +| Cyst | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M + M M M M M M M M M + M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 2 2 2 1 2 2 2 2 2 2 2 1 2 2 1 2 2 2 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Histiocyte | 2 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 2 | Interstitium, Inflammation, Focal | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cornea, Inflammation, Chronic | 3 | Lens, Cataract | 2 | __________________________________________________________________________| Harderian Gland | + + + | __________________________________________________________________________| Zymbal's Gland | M + + + + + M M + + + + M + + + + + M M + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 2 2 1 1 1 1 1 1 1 1 2| Renal Tubule, Dilatation, Focal | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + M + M M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Basophilic Focus | X X | Clear Cell Focus | X X X | Cytomegaly, Focal | 2 | Eosinophilic Focus | X X X X X X X X| Fatty Change, Focal | 1 | Hematopoietic Cell Proliferation | 3 | Mixed Cell Focus | X X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinar Cell, Atrophy | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 3 | Ulcer, Focal | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X | Hyperplasia, Focal | | Hypertrophy, Focal | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + M + M M + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + M + + + + + +| Pars Distalis, Cyst | X | Pars Nervosa, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Hyperplasia, Focal | 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | Inflammation, Chronic, Focal | 2 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + | Duct, Dilatation | 3 3 2 3 3 3 3 3 3 2 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| Dilatation | | Hyperplasia, Focal | 2 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | 2 | Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Lymphoid | 3 | Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2 | Hyperplasia, Lymphoid | 2 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | | Hematopoietic Cell Proliferation | 2 2 2 | Hyperplasia, Lymphoid | 2 2 2 | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + M + + + + + + + +| Cyst | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | 3 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 2 2 2 1 2 2 1 2 2 2 1 2 2 1 2 2 2 2 2 2 1 2 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Histiocyte | 2 | Alveolar Epithelium, Hyperplasia, | | Focal | | Interstitium, Inflammation, Focal | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cornea, Inflammation, Chronic | | Lens, Cataract | | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | + M + M M M + + + + + M + + M M + M + + + + + M +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 1 1 1 1 1 1 1| Renal Tubule, Dilatation, Focal | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Gallbladder | | 47 | __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | Diverticulum | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Rectum | | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 49 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | | 48 | Hyperplasia, Lymphoid | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 49 | __________________________________________________________________________|____________| Liver | | 50 | Angiectasis, Focal | | 1 2.0| Basophilic Focus | | 5 | Clear Cell Focus | | 5 | Cytomegaly, Focal | | 1 2.0| Eosinophilic Focus | | 12 | Fatty Change, Focal | | 1 1.0| Hematopoietic Cell Proliferation | | 1 3.0| Mixed Cell Focus | | 5 | __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | | 50 | Acinar Cell, Atrophy | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | Hyperplasia, Focal | | 3 2.7| Ulcer, Focal | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | | 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 50 | Accessory Adrenal Cortical Nodule | | 1 | Hyperplasia, Focal | | 2 2.5| Hypertrophy, Focal | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | | 50 | __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | | 43 | __________________________________________________________________________|____________| Pituitary Gland | | 48 | Pars Distalis, Cyst | | 2 | Pars Nervosa, Cyst | | 1 | __________________________________________________________________________|____________| Thyroid Gland | | 50 | Follicular Cell, Hyperplasia, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 50 | Granuloma Sperm | | 2 2.0| Inflammation, Chronic, Focal | | 2 2.0| __________________________________________________________________________|____________| Preputial Gland | | 23 | Duct, Dilatation | | 23 2.8| __________________________________________________________________________|____________| Prostate | | 49 | Dilatation | | 1 2.0| Hyperplasia, Focal | | 4 1.5| __________________________________________________________________________|____________| Seminal Vesicle | | 50 | Dilatation | | 1 2.0| __________________________________________________________________________|____________| Testes | | 50 | Atrophy, Focal | | 1 2.0| Atrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | Angiectasis, Focal | | 1 2.0| Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | | 49 | Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 4 2.3| Hyperplasia, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 49 | Hemorrhage | | 3 2.3| Hyperplasia, Lymphoid | | 4 2.0| __________________________________________________________________________|____________| Spleen | | 50 | Developmental Malformation | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | | 3 2.0| Hyperplasia, Lymphoid | | 4 2.0| __________________________________________________________________________|____________| Thymus | | 45 | Cyst | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 2 | __________________________________________________________________________|____________| Skin | | 50 | Inflammation, Chronic Active, Focal | | 3 2.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Mineralization, Focal | | 42 1.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Infiltration Cellular, Focal, | | | Histiocyte | | 2 2.0| Alveolar Epithelium, Hyperplasia, | | | Focal | | 2 2.0| Interstitium, Inflammation, Focal | | 1 1.0| __________________________________________________________________________|____________| Nose | | 50 | __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cornea, Inflammation, Chronic | | 1 3.0| Lens, Cataract | | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | | 4 | __________________________________________________________________________|____________| Zymbal's Gland | | 34 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Nephropathy | | 20 1.2| Renal Tubule, Dilatation, Focal | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 2| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 4| 8| 8| 8| 2| 8| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + I + + M + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | Basophilic Focus | X X X | Clear Cell Focus | X X X | Eosinophilic Focus | X X X X X X | Fatty Change, Focal | 1 1 2 | Inflammation, Chronic, Focal | 2 | Leukocytosis | | Mixed Cell Focus | | Necrosis, Focal | 2 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2| Ulcer, Focal | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | | Inflammation, Chronic Active, Focal | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Hypertrophy, Focal | 2 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + I + + + + + + + + + + + + M +| Cyst | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + M + +| Pars Distalis, Hyperplasia, Focal | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 2| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 4| 8| 8| 8| 2| 8| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicle, Dilatation, Focal | 2 | Follicular Cell, Hypertrophy, Focal | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + | Inflammation, Chronic Active | 3 | Duct, Dilatation | 3 3 3 4 3 3 3 3 2 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Degeneration, Focal | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Hyperplasia, Lymphoid | 2 3 | Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + M + + + + + + + + + +| Cyst | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M I M I M M M M M M + + M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Abscess | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 2| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 4| 8| 8| 8| 2| 8| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Mineralization, Focal | 2 2 2 2 2 1 1 2 2 2 1 2 2 2 1 2 2 2 2 1 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Histiocyte | 1 | Leukocytosis | | Alveolar Epithelium, Hyperplasia, | | Focal | 1 2 2 | Interstitium, Inflammation, Focal | 1 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic | 3 | __________________________________________________________________________| Harderian Gland | + + | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + M + + M + M + + M + + + + +| Inflammation, Chronic Active | | Duct, Dilatation | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct, Chronic, Focal | 2 | Mineralization, Focal | 1 | Nephropathy | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 3 1| Renal Tubule, Dilatation, Focal | 3 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 8| 8| 8| 0| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + A + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | Basophilic Focus | X | Clear Cell Focus | X X | Eosinophilic Focus | X X X X | Fatty Change, Focal | | Inflammation, Chronic, Focal | | Leukocytosis | 2 | Mixed Cell Focus | X X | Necrosis, Focal | 3 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Ulcer, Focal | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | 3 | Inflammation, Chronic Active, Focal | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Hypertrophy, Focal | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + M + + M M + + M + + + +| Cyst | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia, Focal | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 69 NTP 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 8| 8| 8| 0| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicle, Dilatation, Focal | | Follicular Cell, Hypertrophy, Focal | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + | Inflammation, Chronic Active | 3 | Duct, Dilatation | 4 3 2 2 3 3 3 3 2 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 1 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | Degeneration, Focal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| Cyst | | Hyperplasia, Lymphoid | 3 2 | Hyperplasia, Plasma Cell | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 3 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + M M + + + + + + + + + + + + +| Cyst | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Abscess | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 8| 8| 8| 0| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | 2 | Mineralization, Focal | 2 2 2 2 1 2 2 2 2 1 1 2 2 2 1 1 1 2 2 2 2 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Focal, | | Histiocyte | | Leukocytosis | 2 | Alveolar Epithelium, Hyperplasia, | | Focal | | Interstitium, Inflammation, Focal | 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic | | __________________________________________________________________________| Harderian Gland | + + | __________________________________________________________________________| Zymbal's Gland | M + + + + + + + + + M + + + + M + M + + + + + + +| Inflammation, Chronic Active | 2 | Duct, Dilatation | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct, Chronic, Focal | 2 | Mineralization, Focal | | Nephropathy | 1 1 1 1 1 1 1 2 1 2 1 1 1| Renal Tubule, Dilatation, Focal | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Gallbladder | | 46 | __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 47 | __________________________________________________________________________|____________| Liver | | 50 | Angiectasis, Focal | | 1 2.0| Basophilic Focus | | 4 | Clear Cell Focus | | 5 | Eosinophilic Focus | | 10 | Fatty Change, Focal | | 3 1.3| Inflammation, Chronic, Focal | | 1 2.0| Leukocytosis | | 1 2.0| Mixed Cell Focus | | 2 | Necrosis, Focal | | 4 3.0| __________________________________________________________________________|____________| Pancreas | | 50 | Cyst | | 1 | __________________________________________________________________________|____________| Salivary Glands | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | Hyperplasia, Focal | | 1 2.0| Ulcer, Focal | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | | 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Inflammation, Acute, Focal | | 1 3.0| Inflammation, Chronic Active, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 50 | Hyperplasia, Focal | | 2 2.0| Hypertrophy, Focal | | 3 1.7| __________________________________________________________________________|____________| Adrenal Medulla | | 50 | Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 72 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | | 42 | Cyst | | 1 | __________________________________________________________________________|____________| Pituitary Gland | | 48 | Pars Distalis, Hyperplasia, Focal | | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | | 50 | Follicle, Dilatation, Focal | | 1 2.0| Follicular Cell, Hypertrophy, Focal | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 50 | __________________________________________________________________________|____________| Preputial Gland | | 23 | Inflammation, Chronic Active | | 2 3.0| Duct, Dilatation | | 22 2.9| __________________________________________________________________________|____________| Prostate | | 50 | Hyperplasia, Focal | | 6 1.2| __________________________________________________________________________|____________| Seminal Vesicle | | 50 | Dilatation | | 1 4.0| __________________________________________________________________________|____________| Testes | | 50 | Angiectasis, Focal | | 1 2.0| Degeneration, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | __________________________________________________________________________|____________| Lymph Node | | 2 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 49 | Cyst | | 1 | Hyperplasia, Lymphoid | | 4 2.5| Hyperplasia, Plasma Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 50 | Hemorrhage | | 2 3.0| __________________________________________________________________________|____________| Spleen | | 50 | Hematopoietic Cell Proliferation | | 3 2.7| Hyperplasia, Lymphoid | | 2 2.0| __________________________________________________________________________|____________| Thymus | | 46 | Cyst | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 3 | __________________________________________________________________________|____________| Skin | | 50 | Subcutaneous Tissue, Abscess | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Hemorrhage, Focal | | 1 2.0| Mineralization, Focal | | 43 1.7| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Infiltration Cellular, Focal, | | | Histiocyte | | 1 1.0| Leukocytosis | | 1 2.0| Alveolar Epithelium, Hyperplasia, | | | Focal | | 3 1.7| Interstitium, Inflammation, Focal | | 3 1.3| __________________________________________________________________________|____________| Nose | | 50 | Inflammation, Acute, Focal | | 3 1.3| __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cornea, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | | 4 | __________________________________________________________________________|____________| Zymbal's Gland | | 42 | Inflammation, Chronic Active | | 1 2.0| Duct, Dilatation | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Infarct, Chronic, Focal | | 2 2.0| Mineralization, Focal | | 1 1.0| Nephropathy | | 30 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 74 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Renal Tubule, Dilatation, Focal | | 3 2.7| __________________________________________________________________________|____________| Urinary Bladder | | 50 | Dilatation | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 75 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Inflammation, Acute | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| Inflammation, Acute, Focal | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X | Clear Cell Focus | X | Eosinophilic Focus | X X X X X X X X X X X X X X X X X| Fatty Change, Focal | 2 2 | Mixed Cell Focus | | Necrosis, Focal | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinar Cell, Atrophy | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Hemorrhage, Focal | | Hyperplasia, Focal | 1 2 | Hypertrophy, Focal | 2 3 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M M + M + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Dilatation, Focal | | Follicular Cell, Hyperplasia, Focal | 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ductus Deferens | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + +| Inflammation, Chronic Active | | Duct, Dilatation | 3 3 3 3 2 2 3 3| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | __________________________________________________________________________| Lymph Node | | Mediastinal, Congestion | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| Cyst | | Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Histiocyte | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Thymus | + + + + + + + + + M + M + + + + + + M + + + + + +| Cyst | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M + M + M M M + M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 1 2 2 2 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | Interstitium, Inflammation, Focal | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Congestion | | Inflammation, Acute, Focal | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + + + + M + M + + + + M M + + + + M + + + + + M M| Duct, Dilatation | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Focal, Osseous | | Nephropathy | 1 2 1 1 2 1 | Renal Tubule, Dilatation, Focal | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Focal, Osseous | | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M M +| Hyperplasia | | Inflammation, Acute | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute, Focal | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X | Clear Cell Focus | X X X | Eosinophilic Focus | X X X X X X X X X X X| Fatty Change, Focal | 2 1 | Mixed Cell Focus | X | Necrosis, Focal | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinar Cell, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hemorrhage, Focal | 2 | Hyperplasia, Focal | 2 | Hypertrophy, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + M + + + + + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + M + + M + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Dilatation, Focal | 2 | Follicular Cell, Hyperplasia, Focal | 3 3 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ductus Deferens | + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + | Inflammation, Chronic Active | 3 | Duct, Dilatation | 3 2 3 3 3 3 3 3 3 3 2 2 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 3 | __________________________________________________________________________| Lymph Node | + + + | Mediastinal, Congestion | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| Cyst | X | Hyperplasia, Lymphoid | | Infiltration Cellular, Histiocyte | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 3 | __________________________________________________________________________| Thymus | + + M + + M + + + + M + + + + M + + + + M + + + +| Cyst | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M + M M M I M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization, Focal | 2 2 1 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 1 2 2 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 1 | Interstitium, Inflammation, Focal | 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Congestion | 3 | Inflammation, Acute, Focal | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | M + + M + + + + + + + M + + + + + + M M + M + + +| Duct, Dilatation | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Focal, Osseous | 2 | Nephropathy | 1 2 1 1 1 2 1 2 1 1 1 1 1| Renal Tubule, Dilatation, Focal | 3 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Focal, Osseous | 1 | _____________________________________________________________________________________________________________________| Page 81 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Gallbladder | | 47 | Hyperplasia | | 1 3.0| Inflammation, Acute | | 2 1.5| __________________________________________________________________________|____________| Intestine Large, Colon | | 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 49 | Inflammation, Acute, Focal | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | Hyperplasia, Lymphoid | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | | 48 | __________________________________________________________________________|____________| Liver | | 50 | Basophilic Focus | | 9 | Clear Cell Focus | | 4 | Eosinophilic Focus | | 28 | Fatty Change, Focal | | 4 1.8| Mixed Cell Focus | | 1 | Necrosis, Focal | | 3 2.0| __________________________________________________________________________|____________| Pancreas | | 50 | Acinar Cell, Atrophy | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Hyperplasia, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 50 | Atrophy | | 1 3.0| Hemorrhage, Focal | | 1 2.0| Hyperplasia, Focal | | 3 1.7| Hypertrophy, Focal | | 4 2.3| __________________________________________________________________________|____________| Adrenal Medulla | | 50 | Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 43 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | | 48 | __________________________________________________________________________|____________| Thyroid Gland | | 50 | Follicle, Dilatation, Focal | | 1 2.0| Follicular Cell, Hyperplasia, Focal | | 5 2.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ductus Deferens | | 1 | __________________________________________________________________________|____________| Epididymis | | 50 | __________________________________________________________________________|____________| Preputial Gland | | 21 | Inflammation, Chronic Active | | 1 3.0| Duct, Dilatation | | 21 2.8| __________________________________________________________________________|____________| Prostate | | 50 | Hyperplasia, Focal | | 2 1.5| __________________________________________________________________________|____________| Seminal Vesicle | | 50 | __________________________________________________________________________|____________| Testes | | 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | Angiectasis, Focal | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | | 3 | Mediastinal, Congestion | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | | 48 | Cyst | | 1 | Hyperplasia, Lymphoid | | 1 2.0| Infiltration Cellular, Histiocyte | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 50 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Spleen | | 50 | Hematopoietic Cell Proliferation | | 4 2.3| __________________________________________________________________________|____________| Thymus | | 42 | Cyst | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 4 | __________________________________________________________________________|____________| Skin | | 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 NTP Experiment-Test: 05130-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/24/97 Route: DOSED FEED Time: 16:32:00 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone | | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | Mineralization, Focal | | 43 1.8| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Hemorrhage, Focal | | 1 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | | 2 1.5| Interstitium, Inflammation, Focal | | 2 1.0| __________________________________________________________________________|____________| Nose | | 50 | Congestion | | 1 3.0| Inflammation, Acute, Focal | | 1 1.0| __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 37 | Duct, Dilatation | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Metaplasia, Focal, Osseous | | 1 2.0| Nephropathy | | 19 1.3| Renal Tubule, Dilatation, Focal | | 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | | 50 | Metaplasia, Focal, Osseous | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 84 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------