National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2916

TDMS Study 05133-04 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            ACETONITRILE


NTP Experiment-Test: 05133-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06




       Facility:  Battelle Northwest

       Chemical CAS #:  75-05-8

       Lock Date:  07/17/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            5            8            5                                     
    Moribund Sacrifice                                15           12           13           13                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                28           32           29           32                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (52)         (55)         (51)         (56)                                   
   Intestine Large, Cecum                             (55)         (56)         (58)         (56)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Intestine Small, Duodenum                          (52)         (54)         (54)         (55)                                   
   Intestine Small, Jejunum                           (54)         (56)         (56)         (57)                                   
   Intestine Small, Ileum                             (55)         (57)         (55)         (57)                                   
   Liver                                              (59)         (60)         (60)         (59)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Hemangiosarcoma, Multiple                                                  1 (2%)                                             
      Hepatocellular Carcinoma                         5 (8%)       5 (8%)       4 (7%)       4 (7%)                                
      Hepatocellular Carcinoma, Multiple               2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Hepatocellular Adenoma                           3 (5%)       9 (15%)      7 (12%)      4 (7%)                                
      Hepatocellular Adenoma, Multiple                 1 (2%)       1 (2%)       2 (3%)       2 (3%)                                
      Histiocytic Sarcoma                              2 (3%)                    1 (2%)       1 (2%)                                
   Mesentery                                          (10)         (16)         (7)          (5)                                    
      Carcinoma, Metastatic, Ovary                                  1 (6%)                                                          
      Sarcoma Stromal, Metastatic, Uterus                           1 (6%)                                                          
      Fat, Carcinoma, Metastatic, Pancreas                                       1 (14%)                                            
      Fat, Hemangioma                                               1 (6%)                                                          
      Fat, Histiocytic Sarcoma                                      1 (6%)                                                          
   Pancreas                                           (59)         (59)         (60)         (58)                                   
      Adenocarcinoma                                                             1 (2%)                                             
      Fibrosarcoma                                                               1 (2%)                                             
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Salivary Glands                                    (59)         (60)         (60)         (59)                                   
   Stomach, Forestomach                               (59)         (60)         (60)         (58)                                   
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)       3 (5%)                                
                                                             Page   2                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Glandular                                 (59)         (58)         (60)         (58)                                   
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (60)         (59)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (59)         (60)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Capsule, Adenoma                                              1 (2%)                                                          
   Adrenal Medulla                                    (58)         (58)         (60)         (58)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (3%)                                                                       
   Islets, Pancreatic                                 (59)         (59)         (60)         (57)                                   
      Adenoma                                                                    2 (3%)                                             
   Pituitary Gland                                    (58)         (59)         (60)         (58)                                   
      Pars Distalis, Adenoma                          14 (24%)     14 (24%)     15 (25%)      6 (10%)                               
      Pars Intermedia, Adenoma                                                                2 (3%)                                
   Thyroid Gland                                      (59)         (58)         (60)         (59)                                   
      Bilateral, Follicular Cell, Adenoma                                        1 (2%)                                             
      Follicular Cell, Adenoma                         2 (3%)       3 (5%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)                       (1)                                                 
      Sarcoma                                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (58)         (57)         (58)         (57)                                   
      Arrhenoblastoma NOS                              1 (2%)                                                                       
      Cystadenoma                                      1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Luteoma                                          1 (2%)                                                                       
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
      Yolk Sac Carcinoma                                            1 (2%)                                                          
   Uterus                                             (59)         (59)         (60)         (59)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Hemangioma                                       1 (2%)       1 (2%)                                                          
      Hemangiosarcoma                                  2 (3%)                                                                       
      Leiomyoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp Stromal                                    2 (3%)       2 (3%)       3 (5%)       3 (5%)                                
      Sarcoma Stromal                                               1 (2%)                                                          
      Cervix, Fibroma                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (59)         (60)         (59)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (3%)                    1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Lymph Node                                         (7)          (9)          (9)          (1)                                    
      Pancreatic, Histiocytic Sarcoma                  1 (14%)                                                                      
      Renal, Histiocytic Sarcoma                       1 (14%)                                                                      
   Lymph Node, Bronchial                              (48)         (54)         (51)         (46)                                   
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)                                                                       
   Lymph Node, Mandibular                             (42)         (45)         (52)         (41)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (54)         (53)         (57)         (51)                                   
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)       1 (2%)                                                          
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Lymph Node, Mediastinal                            (43)         (43)         (44)         (41)                                   
      Histiocytic Sarcoma                              2 (5%)                                                                       
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Spleen                                             (59)         (59)         (60)         (58)                                   
      Hemangiosarcoma                                  2 (3%)                                 1 (2%)                                
      Histiocytic Sarcoma                              2 (3%)                    1 (2%)                                             
   Thymus                                             (54)         (58)         (56)         (51)                                   
      Sarcoma Stromal, Metastatic                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (57)         (60)         (57)                                   
      Adenoacanthoma                                                             1 (2%)                                             
      Adenocarcinoma                                   3 (5%)                    3 (5%)       1 (2%)                                
   Skin                                               (59)         (60)         (60)         (59)                                   
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                               2 (3%)                                             
      Subcutaneous Tissue, Sarcoma Stromal,                                                                                         
          Metastatic, Uterus                                        1 (2%)                                                          
                                                             Page   4                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (60)         (60)         (60)                                   
      Osteosarcoma                                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (60)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (60)         (60)         (59)                                   
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)       1 (2%)                                
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     6 (10%)      2 (3%)       4 (7%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                 1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
      Histiocytic Sarcoma                              2 (3%)                                 1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
   Nose                                               (59)         (60)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (1)          (2)          (1)                                    
      Adenocarcinoma                                                             1 (50%)      1 (100%)                              
      Adenoma                                          3 (100%)     1 (100%)     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (59)         (60)         (58)                                   
      Histiocytic Sarcoma                              2 (3%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (57)         (57)         (59)         (57)                                   
                                                             Page   5                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Lymphoma Malignant                               1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   6 (10%)     10 (17%)      9 (15%)      3 (5%)                                
      Lymphoma Malignant Mixed                         5 (8%)       7 (12%)      7 (12%)     11 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          38          40          33                                       
     Total Primary Neoplasms                           74          66          71          52                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          27          27          19                                       
     Total Benign Neoplasms                            40          38          38          24                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          23          27          24                                       
     Total Malignant Neoplasms                         33          28          33          28                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           3           3                                       
     Total Metastatic Neoplasm                          3          12           9           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           14           16            6                                     
    Natural Death                                      5            4            2            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           32           32           43                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (57)         (60)         (58)         (59)                                   
      Anus, Leiomyosarcoma                                          1 (2%)                                                          
   Intestine Small, Duodenum                          (56)         (58)         (58)         (58)                                   
      Adenoma                                          1 (2%)                                                                       
   Intestine Small, Jejunum                           (55)         (58)         (57)         (59)                                   
      Carcinoma                                        1 (2%)                                 1 (2%)                                
   Liver                                              (60)         (60)         (59)         (60)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                               1 (2%)       1 (2%)       1 (2%)                                
      Hemangiosarcoma, Multiple                        1 (2%)       2 (3%)                    2 (3%)                                
      Hepatocellular Carcinoma                         4 (7%)      11 (18%)      7 (12%)      6 (10%)                               
      Hepatocellular Carcinoma, Multiple               4 (7%)       3 (5%)       6 (10%)      1 (2%)                                
      Hepatocellular Adenoma                          11 (18%)     11 (18%)     15 (25%)     10 (17%)                               
      Hepatocellular Adenoma, Multiple                 4 (7%)       2 (3%)       5 (8%)       1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Bile Duct, Carcinoma                                                                    1 (2%)                                
   Mesentery                                          (3)          (3)          (3)          (3)                                    
      Sarcoma, Metastatic, Skin                        1 (33%)                                                                      
      Fat, Hemangioma                                                            1 (33%)      1 (33%)                               
   Pancreas                                           (59)         (60)         (58)         (60)                                   
      Adenocarcinoma                                                1 (2%)                                                          
   Salivary Glands                                    (60)         (60)         (58)         (60)                                   
   Stomach, Forestomach                               (59)         (60)         (58)         (60)                                   
      Squamous Cell Papilloma                                                    1 (2%)       2 (3%)                                
   Stomach, Glandular                                 (59)         (60)         (58)         (60)                                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (60)         (58)         (60)                                   
      Adenoma                                          1 (2%)                                                                       
      Capsule, Adenoma                                 1 (2%)       4 (7%)                    1 (2%)                                
   Adrenal Medulla                                    (59)         (60)         (57)         (60)                                   
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (57)         (60)         (58)         (60)                                   
      Adenoma                                                       1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (56)         (58)         (56)         (59)                                   
      Pars Intermedia, Adenoma                         1 (2%)                                 1 (2%)                                
   Thyroid Gland                                      (59)         (60)         (58)         (60)                                   
      C-Cell, Adenoma                                  1 (2%)                                                                       
      Follicular Cell, Adenoma                         2 (3%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (60)         (60)         (59)         (60)                                   
      Interstitial Cell, Adenoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (58)         (60)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
   Lymph Node                                         (3)          (2)          (2)                                                 
   Lymph Node, Bronchial                              (41)         (44)         (45)         (50)                                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
   Lymph Node, Mandibular                             (43)         (39)         (36)         (44)                                   
   Lymph Node, Mesenteric                             (56)         (59)         (57)         (58)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node, Mediastinal                            (47)         (45)         (44)         (40)                                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Hemangiosarcoma                                                                         1 (3%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (59)         (60)         (58)         (60)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Thymus                                             (53)         (54)         (48)         (57)                                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (59)         (59)         (60)                                   
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Prepuce, Squamous Cell Carcinoma                 1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (58)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     5 (8%)      11 (18%)      8 (14%)     20 (33%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   6 (10%)      7 (12%)      4 (7%)       4 (7%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   2 (3%)                                             
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      4 (7%)       2 (3%)       5 (9%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Mediastinum, Hemangioma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (5)          (1)          (2)                                    
      Adenoma                                          5 (100%)     4 (80%)      1 (100%)     2 (100%)                              
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                                                             Page  10                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (58)         (60)                                   
      Pelvis, Hemangioma                               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Mixed                         2 (3%)       3 (5%)       3 (5%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05133-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      50 PPM       100 PPM      200 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          44          40          38                                       
     Total Primary Neoplasms                           60          71          59          62                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26          29          28          31                                       
     Total Benign Neoplasms                            36          39          34          41                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          27          19          18                                       
     Total Malignant Neoplasms                         24          32          25          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           3           5                                                   
     Total Metastatic Neoplasm                          7           7           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.