Share This:
https://ntp.niehs.nih.gov/go/2918

TDMS Study 05133-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95       
EXPERIMENT: 05133 TEST: 04                                                                                     TIME: 07:11:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 000242       
PATHOLOGIST: R. MILLER                       HAILEY, JAMES R.                                                  CAS: 75-05-8         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95       
EXPERIMENT: 05133 TEST: 04                                                                                     TIME: 07:11:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 000242       
PATHOLOGIST: R. MILLER                       HAILEY, JAMES R.                                                  CAS: 75-05-8         


                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95       
EXPERIMENT: 05133 TEST: 04                                                                                     TIME: 07:11:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 000242       
PATHOLOGIST: R. MILLER                       HAILEY, JAMES R.                                                  CAS: 75-05-8         


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                          IN THE ANALYSIS OF THE STUDY OF ACETONITRILE
              ====================================================================================================
                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Liver                         Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              All Organs                    Malignant Tumors
              ====================================================================================================
                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma: Benign, Complex, Malignant, NOS
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Pituitary Gland: Pars Intermedia
                                            Adenoma
              All Organs                    Benign Tumors
              ====================================================================================================
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE   1
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/58 (3%)    4/60 (7%)    0/58 (0%)    1/60 (2%)  |  0/59 (0%)    1/59 (2%)    0/60 (0%)    0/59 (0%)  |
|ADJUSTED (b)           |   6.3%        12.5%         0.0%         2.3%      |   0.0%         3.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/32 (6%)    4/32 (13%)   0/32 (0%)    1/43 (2%)  |  0/28 (0%)    1/33 (3%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      733 (T)      ---          733 (T)   |   ---          735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.130N     P=0.335      P=0.238N     P=0.397N   |  P=0.555N     P=0.533        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.130N     P=0.335      P=0.238N     P=0.397N   |  P=0.555N     P=0.533        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.130N     P=0.335      P=0.238N     P=0.397N   |  P=0.555N     P=0.533        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.194N                                          |  P=0.567N                                          |
|FISHER EXACT           |               P=0.356      P=0.248N     P=0.487N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/59 (2%)    0/60 (0%)    1/57 (2%)    0/60 (0%)  |  2/58 (3%)    0/58 (0%)    0/60 (0%)    0/58 (0%)  |
|ADJUSTED (b)           |   2.9%         0.0%         3.1%         0.0%      |   5.3%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/32 (0%)    0/32 (0%)    1/32 (3%)    0/43 (0%)  |  1/27 (4%)    0/33 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   714          ---          733 (T)      ---       |   426          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.353N     P=0.512N     P=0.757      P=0.454N   |  P=0.111N     P=0.218N     P=0.230N     P=0.225N   |
|INCIDENTAL TUMOR       |  P=0.422N     P=0.450N     P=0.746N     P=0.612N   |  P=0.082N     P=0.325N     P=0.486N     P=0.151N   |
|LOGISTIC REGRESSION    |  P=0.367N     P=0.497N     P=0.763N     P=0.471N   |  P=0.102N     P=0.247N     P=0.251N     P=0.215N   |
|COCHRAN-ARMITAGE       |  P=0.404N                                          |  P=0.114N                                          |
|FISHER EXACT           |               P=0.496N     P=0.743      P=0.496N   |               P=0.248N     P=0.239N     P=0.248N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE   2
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/59 (2%)    0/60 (0%)    1/57 (2%)    0/60 (0%)  |  3/58 (5%)    0/58 (0%)    0/60 (0%)    0/58 (0%)  |
|ADJUSTED (b)           |   2.9%         0.0%         3.1%         0.0%      |   9.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/32 (0%)    0/32 (0%)    1/32 (3%)    0/43 (0%)  |  2/27 (7%)    0/33 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   714          ---          733 (T)      ---       |   426          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.353N     P=0.512N     P=0.757      P=0.454N   |  P=0.044N*    P=0.100N     P=0.113N     P=0.105N   |
|INCIDENTAL TUMOR       |  P=0.422N     P=0.450N     P=0.746N     P=0.612N   |  P=0.033N*    P=0.150N     P=0.222N     P=0.069N   |
|LOGISTIC REGRESSION    |  P=0.367N     P=0.497N     P=0.763N     P=0.471N   |  P=0.045N*    P=0.123N     P=0.120N     P=0.118N   |
|COCHRAN-ARMITAGE       |  P=0.404N                                          |  P=0.047N*                                         |
|FISHER EXACT           |               P=0.496N     P=0.743      P=0.496N   |               P=0.122N     P=0.116N     P=0.122N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    4/60 (7%)    1/60 (2%)    2/60 (3%)  |  3/59 (5%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |  11.9%        11.4%         3.1%         4.5%      |   8.3%         3.0%         3.4%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/32 (6%)    3/32 (9%)    1/32 (3%)    1/43 (2%)  |  1/28 (4%)    1/33 (3%)    1/29 (3%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   437          602          733 (T)      727       |   623          735 (T)      735 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.073N     P=0.492N     P=0.106N     P=0.156N   |  P=0.071N     P=0.283N     P=0.296N     P=0.125N   |
|INCIDENTAL TUMOR       |  P=0.157N     P=0.556N     P=0.144N     P=0.422N   |  P=0.086N     P=0.299N     P=0.292N     P=0.200N   |
|LOGISTIC REGRESSION    |  P=0.108N     P=0.500N     P=0.105N     P=0.231N   |  P=0.074N     P=0.295N     P=0.287N     P=0.125N   |
|COCHRAN-ARMITAGE       |  P=0.115N                                          |  P=0.072N                                          |
|FISHER EXACT           |               P=0.500N     P=0.103N     P=0.219N   |               P=0.303N     P=0.303N     P=0.119N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE   3
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    4/60 (7%)    1/60 (2%)    2/60 (3%)  |  3/59 (5%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |  11.9%        11.4%         3.1%         4.5%      |   8.3%         3.0%         6.9%         3.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/32 (6%)    3/32 (9%)    1/32 (3%)    1/43 (2%)  |  1/28 (4%)    1/33 (3%)    2/29 (7%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   437          602          733 (T)      727       |   623          735 (T)      735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.073N     P=0.492N     P=0.106N     P=0.156N   |  P=0.266N     P=0.283N     P=0.485N     P=0.298N   |
|INCIDENTAL TUMOR       |  P=0.157N     P=0.556N     P=0.144N     P=0.422N   |  P=0.307N     P=0.299N     P=0.481N     P=0.405N   |
|LOGISTIC REGRESSION    |  P=0.108N     P=0.500N     P=0.105N     P=0.231N   |  P=0.287N     P=0.295N     P=0.472N     P=0.316N   |
|COCHRAN-ARMITAGE       |  P=0.115N                                          |  P=0.275N                                          |
|FISHER EXACT           |               P=0.500N     P=0.103N     P=0.219N   |               P=0.303N     P=0.492N     P=0.303N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |  0/59 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.3%         0.0%         0.0%         2.3%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/32 (6%)    0/32 (0%)    0/32 (0%)    1/43 (2%)  |  0/28 (0%)    0/33 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          ---          733 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.384N     P=0.238N     P=0.238N     P=0.397N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.384N     P=0.238N     P=0.238N     P=0.397N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.384N     P=0.238N     P=0.238N     P=0.397N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.461N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.248N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE   4
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/57 (0%)    1/60 (2%)    0/58 (0%)    1/60 (2%)  |  0/59 (0%)    0/59 (0%)    2/60 (3%)    0/57 (0%)  |
|ADJUSTED (b)           |   0.0%         2.6%         0.0%         2.3%      |   0.0%         0.0%         6.9%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |  0/31 (0%)    0/32 (0%)    0/32 (0%)    1/43 (2%)  |  0/28 (0%)    0/33 (0%)    2/29 (7%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          664          ---          733 (T)   |   ---          ---          735 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.465      P=0.505        (e)        P=0.565    |  P=0.611        (e)        P=0.246        (e)      |
|INCIDENTAL TUMOR       |  P=0.393      P=0.581        (e)        P=0.565    |  P=0.611        (e)        P=0.246        (e)      |
|LOGISTIC REGRESSION    |  P=0.434      P=0.511        (e)        P=0.565    |  P=0.611        (e)        P=0.246        (e)      |
|COCHRAN-ARMITAGE       |  P=0.413                                           |  P=0.589                                           |
|FISHER EXACT           |               P=0.513        (e)        P=0.513    |                 (e)        P=0.252        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/60 (5%)    1/59 (2%)    3/60 (5%)  |  0/59 (0%)    0/60 (0%)    1/60 (2%)    1/59 (2%)  |
|ADJUSTED (b)           |   3.0%         9.4%         2.9%         6.4%      |   0.0%         0.0%         3.4%         2.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    3/32 (9%)    0/32 (0%)    0/43 (0%)  |  0/28 (0%)    0/33 (0%)    1/29 (3%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   729          733 (T)      720          554       |   ---          ---          735 (T)      509       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.431      P=0.304      P=0.760      P=0.387    |  P=0.236        (e)        P=0.507      P=0.487    |
|INCIDENTAL TUMOR       |  P=0.203      P=0.329      P=0.738N     P=0.076    |  P=0.360        (e)        P=0.507      P=0.638    |
|LOGISTIC REGRESSION    |  P=0.360      P=0.295      P=0.763      P=0.316    |  P=0.244        (e)        P=0.507      P=0.561    |
|COCHRAN-ARMITAGE       |  P=0.313                                           |  P=0.234                                           |
|FISHER EXACT           |               P=0.309      P=0.748      P=0.309    |                 (e)        P=0.504      P=0.500    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE   5
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/60 (25%)  13/60 (22%)  20/59 (34%)  11/60 (18%) |  4/59 (7%)   10/60 (17%)   9/60 (15%)   6/59 (10%) |
|ADJUSTED (b)           |  37.2%        32.6%        50.9%        23.5%      |  12.0%        25.1%        26.8%        18.8%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   1/10 (10%)   2/10 (20%)   1/10 (10%) |  0/10 (0%)    2/10 (20%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  9/32 (28%)   8/32 (25%)  14/32 (44%)   8/43 (19%) |  2/28 (7%)    6/33 (18%)   6/29 (21%)   6/32 (19%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      434          456 (I)      456 (I)   |   569          457 (I)      457 (I)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.099N     P=0.410N     P=0.223      P=0.097N   |  P=0.535      P=0.118      P=0.144      P=0.433    |
|INCIDENTAL TUMOR       |  P=0.264N     P=0.439N     P=0.222      P=0.257N   |  P=0.453      P=0.084      P=0.152      P=0.351    |
|LOGISTIC REGRESSION    |  P=0.244N     P=0.411N     P=0.201      P=0.210N   |  P=0.453      P=0.083      P=0.141      P=0.352    |
|COCHRAN-ARMITAGE       |  P=0.300N                                          |  P=0.483                                           |
|FISHER EXACT           |               P=0.415N     P=0.194      P=0.253N   |               P=0.081      P=0.126      P=0.371    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/60 (13%)  14/60 (23%)  13/59 (22%)   7/60 (12%) |  7/59 (12%)   6/60 (10%)   6/60 (10%)   5/59 (8%)  |
|ADJUSTED (b)           |  16.5%        28.5%        30.1%        15.0%      |  23.1%        15.8%        16.4%        13.6%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   3/10 (30%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/32 (3%)    1/32 (3%)    4/32 (13%)   4/43 (9%)  |  5/28 (18%)   3/33 (9%)    2/29 (7%)    3/32 (9%)  |
|FIRST INCIDENCE (DAYS) |   437          456 (I)      342          532       |   706          595          570          510       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.183N     P=0.150      P=0.201      P=0.374N   |  P=0.309N     P=0.397N     P=0.456N     P=0.323N   |
|INCIDENTAL TUMOR       |  P=0.339      P=0.088      P=0.105      P=0.331    |  P=0.410N     P=0.508N     P=0.413N     P=0.394N   |
|LOGISTIC REGRESSION    |  P=0.486      P=0.068      P=0.138      P=0.427    |  P=0.355N     P=0.469N     P=0.447N     P=0.404N   |
|COCHRAN-ARMITAGE       |  P=0.305N                                          |  P=0.333N                                          |
|FISHER EXACT           |               P=0.119      P=0.158      P=0.500N   |               P=0.487N     P=0.487N     P=0.381N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE   6
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 22/60 (37%)  25/60 (42%)  32/59 (54%)  16/60 (27%) |  9/59 (15%)  15/60 (25%)  14/60 (23%)  10/59 (17%) |
|ADJUSTED (b)           |  47.1%        50.2%        68.7%        33.0%      |  28.0%        35.8%        37.9%        28.5%      |
|INTERIM SACRIFICE 1 (c)|  3/10 (30%)   4/10 (40%)   2/10 (20%)   1/10 (10%) |  0/10 (0%)    2/10 (20%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           | 10/32 (31%)   9/32 (28%)  18/32 (56%)  11/43 (26%) |  6/28 (21%)   8/33 (24%)   8/29 (28%)   8/32 (25%) |
|FIRST INCIDENCE (DAYS) |   437          434          342          456 (I)   |   569          457 (I)      457 (I)      510       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.034N*    P=0.388      P=0.086      P=0.054N   |  P=0.450N     P=0.217      P=0.222      P=0.585    |
|INCIDENTAL TUMOR       |  P=0.303N     P=0.333      P=0.037 *    P=0.324N   |  P=0.510      P=0.130      P=0.236      P=0.493    |
|LOGISTIC REGRESSION    |  P=0.212N     P=0.344      P=0.042 *    P=0.164N   |  P=0.544      P=0.139      P=0.217      P=0.465    |
|COCHRAN-ARMITAGE       |  P=0.139N                                          |  P=0.504N                                          |
|FISHER EXACT           |               P=0.354      P=0.041 *    P=0.163N   |               P=0.136      P=0.189      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 22/60 (37%)  25/60 (42%)  32/59 (54%)  16/60 (27%) |  9/59 (15%)  15/60 (25%)  14/60 (23%)  10/59 (17%) |
|ADJUSTED (b)           |  47.1%        50.2%        68.7%        33.0%      |  28.0%        35.8%        37.9%        28.5%      |
|INTERIM SACRIFICE 1 (c)|  3/10 (30%)   4/10 (40%)   2/10 (20%)   1/10 (10%) |  0/10 (0%)    2/10 (20%)   1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           | 10/32 (31%)   9/32 (28%)  18/32 (56%)  11/43 (26%) |  6/28 (21%)   8/33 (24%)   8/29 (28%)   8/32 (25%) |
|FIRST INCIDENCE (DAYS) |   437          434          342          456 (I)   |   569          457 (I)      457 (I)      510       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.034N*    P=0.388      P=0.086      P=0.054N   |  P=0.450N     P=0.217      P=0.222      P=0.585    |
|INCIDENTAL TUMOR       |  P=0.303N     P=0.333      P=0.037 *    P=0.324N   |  P=0.510      P=0.130      P=0.236      P=0.493    |
|LOGISTIC REGRESSION    |  P=0.212N     P=0.344      P=0.042 *    P=0.164N   |  P=0.544      P=0.139      P=0.217      P=0.465    |
|COCHRAN-ARMITAGE       |  P=0.139N                                          |  P=0.504N                                          |
|FISHER EXACT           |               P=0.354      P=0.041 *    P=0.163N   |               P=0.136      P=0.189      P=0.500    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE   7
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)  12/60 (20%)  10/58 (17%)  21/60 (35%) |  7/59 (12%)   2/60 (3%)    4/60 (7%)    1/59 (2%)  |
|ADJUSTED (b)           |  20.1%        31.8%        26.8%        41.3%      |  25.0%         6.1%        10.0%         1.8%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   3/10 (30%)   2/10 (20%)   3/10 (30%) |  0/10 (0%)    0/10 (0%)    2/10 (20%)   1/10 (10%) |
|TERMINAL (d)           |  6/32 (19%)   9/32 (28%)   7/32 (22%)  14/43 (33%) |  7/28 (25%)   2/33 (6%)    2/29 (7%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      456 (I)      456 (I)   |   735 (T)      735 (T)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.016 *    P=0.151      P=0.298      P=0.019 *  |  P=0.030N*    P=0.044N*    P=0.243N     P=0.021N*  |
|INCIDENTAL TUMOR       |  P=0.007 **   P=0.151      P=0.304      P=0.005 ** |  P=0.030N*    P=0.044N*    P=0.243N     P=0.021N*  |
|LOGISTIC REGRESSION    |  P=0.005 **   P=0.162      P=0.290      P=0.003 ** |  P=0.040N*    P=0.044N*    P=0.238N     P=0.036N*  |
|COCHRAN-ARMITAGE       |  P=0.002 **                                        |  P=0.038N*                                         |
|FISHER EXACT           |               P=0.159      P=0.275      P=0.002 ** |               P=0.077N     P=0.255N     P=0.031N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   7/60 (12%)   6/58 (10%)   4/60 (7%)  |  1/59 (2%)    1/60 (2%)    0/60 (0%)    1/59 (2%)  |
|ADJUSTED (b)           |  15.1%        17.9%        16.4%         9.3%      |   3.1%         3.0%         0.0%         3.1%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  3/32 (9%)    4/32 (13%)   3/32 (9%)    4/43 (9%)  |  0/28 (0%)    1/33 (3%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      607          733 (T)   |   706          735 (T)      ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.147N     P=0.505      P=0.614N     P=0.238N   |  P=0.599N     P=0.732N     P=0.482N     P=0.739N   |
|INCIDENTAL TUMOR       |  P=0.247N     P=0.521      P=0.595N     P=0.281N   |  P=0.641N     P=0.736      P=0.443N     P=0.703    |
|LOGISTIC REGRESSION    |  P=0.242N     P=0.500      P=0.604      P=0.351N   |  P=0.620N     P=0.752N     P=0.487N     P=0.760    |
|COCHRAN-ARMITAGE       |  P=0.267N                                          |  P=0.617N                                          |
|FISHER EXACT           |               P=0.500      P=0.595      P=0.372N   |               P=0.748N     P=0.496N     P=0.752N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE   8
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/60 (20%)  17/60 (28%)  16/58 (28%)  24/60 (40%) |  8/59 (14%)   3/60 (5%)    4/60 (7%)    2/59 (3%)  |
|ADJUSTED (b)           |  32.7%        43.4%        40.6%        47.4%      |  27.3%         9.1%        10.0%         4.9%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   3/10 (30%)   2/10 (20%)   3/10 (30%) |  0/10 (0%)    0/10 (0%)    2/10 (20%)   1/10 (10%) |
|TERMINAL (d)           |  9/32 (28%)  12/32 (38%)  10/32 (31%)  17/43 (40%) |  7/28 (25%)   3/33 (9%)    2/29 (7%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      456 (I)      456 (I)   |   706          735 (T)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.109      P=0.195      P=0.262      P=0.095    |  P=0.038N*    P=0.057N     P=0.163N     P=0.032N*  |
|INCIDENTAL TUMOR       |  P=0.034 *    P=0.203      P=0.276      P=0.031 *  |  P=0.041N*    P=0.066N     P=0.155N     P=0.041N*  |
|LOGISTIC REGRESSION    |  P=0.019 *    P=0.199      P=0.246      P=0.021 *  |  P=0.052N     P=0.065N     P=0.158N     P=0.053N   |
|COCHRAN-ARMITAGE       |  P=0.012 *                                         |  P=0.049N*                                         |
|FISHER EXACT           |               P=0.197      P=0.226      P=0.014 *  |               P=0.097N     P=0.173N     P=0.047N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  3/59 (5%)    0/60 (0%)    3/60 (5%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.9%         0.0%         7.8%         3.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    0/32 (0%)    0/32 (0%)    0/43 (0%)  |  1/28 (4%)    0/33 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   641          ---          650          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.358N     P=0.109N     P=0.612N     P=0.283N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.492N     P=0.127N     P=0.585N     P=0.405N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.384N     P=0.116N     P=0.639N     P=0.316N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.368N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.119N     P=0.652N     P=0.303N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE   9
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/58 (2%)    2/57 (4%)    1/58 (2%)    1/57 (2%)  |
|ADJUSTED (b)           |                                                    |   3.7%         6.1%         3.6%         3.2%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |
|TERMINAL (d)           |                                                    |  1/27 (4%)    2/33 (6%)    1/28 (4%)    1/31 (3%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   735 (T)      735 (T)      735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.506N     P=0.570      P=0.754N     P=0.731N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.506N     P=0.570      P=0.754N     P=0.731N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.506N     P=0.570      P=0.754N     P=0.731N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.534N                                          |
|FISHER EXACT           |                                                    |               P=0.493      P=0.752N     P=0.748    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    0/58 (0%)    0/56 (0%)    0/59 (0%)  | 14/58 (24%)  14/59 (24%)  15/60 (25%)   6/58 (10%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  41.8%        38.3%        42.2%        17.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/29 (0%)    0/31 (0%)    0/32 (0%)    0/42 (0%)  |  9/27 (33%)  11/33 (33%)  10/29 (34%)   4/32 (13%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   622          646          583          664       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.023N*    P=0.406N     P=0.582N     P=0.027N*  |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.038N*    P=0.530N     P=0.532N     P=0.067N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.030N*    P=0.507N     P=0.556N     P=0.039N*  |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.034N*                                         |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.565N     P=0.542      P=0.042N*  |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE  10
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    0/58 (0%)    0/56 (0%)    1/59 (2%)  |  0/58 (0%)    0/59 (0%)    0/60 (0%)    2/58 (3%)  |
|ADJUSTED (b)           |   3.4%         0.0%         0.0%         2.4%      |   0.0%         0.0%         0.0%         6.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/29 (3%)    0/31 (0%)    0/32 (0%)    1/42 (2%)  |  0/27 (0%)    0/33 (0%)    0/29 (0%)    2/32 (6%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          ---          733 (T)   |   ---          ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.666      P=0.487N     P=0.480N     P=0.677N   |  P=0.052        (e)          (e)        P=0.276    |
|INCIDENTAL TUMOR       |  P=0.666      P=0.487N     P=0.480N     P=0.677N   |  P=0.052        (e)          (e)        P=0.276    |
|LOGISTIC REGRESSION    |  P=0.666      P=0.487N     P=0.480N     P=0.677N   |  P=0.052        (e)          (e)        P=0.276    |
|COCHRAN-ARMITAGE       |  P=0.603                                           |  P=0.045 *                                         |
|FISHER EXACT           |               P=0.491N     P=0.500N     P=0.739N   |                 (e)          (e)        P=0.248    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  0/59 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         6.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    0/32 (0%)    0/32 (0%)    0/43 (0%)  |  0/28 (0%)    0/33 (0%)    1/29 (3%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   457          ---          ---          ---       |   ---          ---          671          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.303N     P=0.504N     P=0.500N     P=0.496N   |  P=0.596        (e)        P=0.244        (e)      |
|INCIDENTAL TUMOR       |  P=0.458N     P=0.581N     P=0.718N     P=0.718N   |  P=0.564        (e)        P=0.275        (e)      |
|LOGISTIC REGRESSION    |  P=0.317N     P=0.488N     P=0.464N     P=0.549N   |  P=0.589        (e)        P=0.251        (e)      |
|COCHRAN-ARMITAGE       |  P=0.306N                                          |  P=0.598                                           |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |                 (e)        P=0.252        (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE  11
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    0/60 (0%)    0/58 (0%)    1/60 (2%)  |  2/59 (3%)    0/59 (0%)    0/60 (0%)    1/58 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         2.3%      |   6.8%         0.0%         0.0%         3.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    0/32 (0%)    0/32 (0%)    1/43 (2%)  |  1/28 (4%)    0/33 (0%)    0/29 (0%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          733 (T)   |   710          ---          ---          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.244        (e)          (e)        P=0.559    |  P=0.440N     P=0.206N     P=0.226N     P=0.455N   |
|INCIDENTAL TUMOR       |  P=0.244        (e)          (e)        P=0.559    |  P=0.481N     P=0.264N     P=0.205N     P=0.547N   |
|LOGISTIC REGRESSION    |  P=0.244        (e)          (e)        P=0.559    |  P=0.460N     P=0.225N     P=0.220N     P=0.497N   |
|COCHRAN-ARMITAGE       |  P=0.200                                           |  P=0.465N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.504    |               P=0.248N     P=0.244N     P=0.506N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    1/60 (2%)    2/60 (3%)  |  1/59 (2%)    0/60 (0%)    1/60 (2%)    3/60 (5%)  |
|ADJUSTED (b)           |   0.0%         0.0%         3.1%         4.7%      |   3.6%         0.0%         3.4%         9.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    0/32 (0%)    1/32 (3%)    2/43 (5%)  |  1/28 (4%)    0/33 (0%)    1/29 (3%)    3/32 (9%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          733 (T)      733 (T)   |   735 (T)      ---          735 (T)      735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.113        (e)        P=0.500      P=0.306    |  P=0.108      P=0.467N     P=0.754N     P=0.353    |
|INCIDENTAL TUMOR       |  P=0.113        (e)        P=0.500      P=0.306    |  P=0.108      P=0.467N     P=0.754N     P=0.353    |
|LOGISTIC REGRESSION    |  P=0.113        (e)        P=0.500      P=0.306    |  P=0.108      P=0.467N     P=0.754N     P=0.353    |
|COCHRAN-ARMITAGE       |  P=0.070                                           |  P=0.099                                           |
|FISHER EXACT           |                 (e)        P=0.500      P=0.248    |               P=0.496N     P=0.748N     P=0.316    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE  12
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/59 (3%)    2/60 (3%)    0/58 (0%)    0/60 (0%)  |  2/59 (3%)    3/58 (5%)    2/60 (3%)    1/59 (2%)  |
|ADJUSTED (b)           |   6.3%         3.4%         0.0%         0.0%      |   7.1%         8.3%         6.4%         3.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    2/10 (20%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/32 (6%)    0/32 (0%)    0/32 (0%)    0/43 (0%)  |  2/28 (7%)    2/33 (6%)    1/29 (3%)    1/32 (3%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      456 (I)      ---          ---       |   735 (T)      639          712          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.073N     P=0.695      P=0.238N     P=0.176N   |  P=0.287N     P=0.562      P=0.673N     P=0.453N   |
|INCIDENTAL TUMOR       |  P=0.073N     P=0.695      P=0.238N     P=0.176N   |  P=0.337N     P=0.574      P=0.659N     P=0.453N   |
|LOGISTIC REGRESSION    |  P=0.097N     P=0.692N     P=0.238N     P=0.176N   |  P=0.317N     P=0.514      P=0.667N     P=0.453N   |
|COCHRAN-ARMITAGE       |  P=0.086N                                          |  P=0.310N                                          |
|FISHER EXACT           |               P=0.684N     P=0.252N     P=0.244N   |               P=0.492      P=0.684N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/59 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |                                                    |   5.5%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  0/28 (0%)    0/33 (0%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   622          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.113N     P=0.225N     P=0.222N     P=0.236N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.149N     P=0.265N     P=0.227N     P=0.401N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.114N     P=0.234N     P=0.232N     P=0.241N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.113N                                          |
|FISHER EXACT           |                                                    |               P=0.244N     P=0.244N     P=0.244N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE  13
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/59 (3%)    2/60 (3%)    3/60 (5%)    3/60 (5%)  |
|ADJUSTED (b)           |                                                    |   6.9%         6.1%         9.1%         9.4%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  1/28 (4%)    2/33 (6%)    2/29 (7%)    3/32 (9%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   720          735 (T)      664          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.404      P=0.637N     P=0.524      P=0.560    |
|INCIDENTAL TUMOR       |                                                    |  P=0.360      P=0.687N     P=0.562      P=0.488    |
|LOGISTIC REGRESSION    |                                                    |  P=0.367      P=0.662N     P=0.534      P=0.530    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.378                                           |
|FISHER EXACT           |                                                    |               P=0.684N     P=0.508      P=0.508    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/59 (3%)    3/60 (5%)    3/60 (5%)    3/60 (5%)  |
|ADJUSTED (b)           |                                                    |   6.9%         8.3%         9.1%         9.4%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  1/28 (4%)    2/33 (6%)    2/29 (7%)    3/32 (9%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   720          639          664          735 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.468      P=0.558      P=0.524      P=0.560    |
|INCIDENTAL TUMOR       |                                                    |  P=0.397      P=0.522      P=0.562      P=0.488    |
|LOGISTIC REGRESSION    |                                                    |  P=0.423      P=0.519      P=0.534      P=0.530    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.444                                           |
|FISHER EXACT           |                                                    |               P=0.508      P=0.508      P=0.508    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE  14
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    1/60 (2%)    2/60 (3%)  |  2/59 (3%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   3.1%         6.3%         3.1%         4.7%      |   7.1%         6.1%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/32 (3%)    2/32 (6%)    1/32 (3%)    2/43 (5%)  |  2/28 (7%)    2/33 (6%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      733 (T)      733 (T)      733 (T)   |   735 (T)      735 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.561      P=0.500      P=0.762      P=0.603    |  P=0.077N     P=0.635N     P=0.230N     P=0.209N   |
|INCIDENTAL TUMOR       |  P=0.561      P=0.500      P=0.762      P=0.603    |  P=0.077N     P=0.635N     P=0.230N     P=0.209N   |
|LOGISTIC REGRESSION    |  P=0.561      P=0.500      P=0.762      P=0.603    |  P=0.077N     P=0.635N     P=0.230N     P=0.209N   |
|COCHRAN-ARMITAGE       |  P=0.444                                           |  P=0.085N                                          |
|FISHER EXACT           |               P=0.500      P=0.752N     P=0.500    |               P=0.684N     P=0.244N     P=0.244N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    4/60 (7%)    1/60 (2%)    5/60 (8%)  |  3/59 (5%)    0/60 (0%)    1/60 (2%)    3/60 (5%)  |
|ADJUSTED (b)           |   5.9%        11.3%         2.9%        10.7%      |   8.9%         0.0%         3.4%         8.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    3/32 (9%)    0/32 (0%)    2/43 (5%)  |  1/28 (4%)    0/33 (0%)    1/29 (3%)    2/32 (6%)  |
|FIRST INCIDENCE (DAYS) |   716          583          720          554       |   622          ---          735 (T)      509       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.339      P=0.338      P=0.500N     P=0.331    |  P=0.438      P=0.107N     P=0.288N     P=0.632N   |
|INCIDENTAL TUMOR       |  P=0.112      P=0.367      P=0.450N     P=0.067    |  P=0.444      P=0.127N     P=0.292N     P=0.643    |
|LOGISTIC REGRESSION    |  P=0.255      P=0.341      P=0.499N     P=0.252    |  P=0.411      P=0.116N     P=0.284N     P=0.653    |
|COCHRAN-ARMITAGE       |  P=0.212                                           |  P=0.428                                           |
|FISHER EXACT           |               P=0.340      P=0.500N     P=0.219    |               P=0.119N     P=0.303N     P=0.652N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE  15
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    6/60 (10%)   2/60 (3%)    7/60 (12%) |  5/59 (8%)    2/60 (3%)    1/60 (2%)    3/60 (5%)  |
|ADJUSTED (b)           |   8.8%        17.4%         6.0%        15.1%      |  15.7%         6.1%         3.4%         8.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/32 (3%)    5/32 (16%)   1/32 (3%)    4/43 (9%)  |  3/28 (11%)   2/33 (6%)    1/29 (3%)    2/32 (6%)  |
|FIRST INCIDENCE (DAYS) |   716          583          720          554       |   622          735 (T)      735 (T)      509       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.340      P=0.245      P=0.500N     P=0.290    |  P=0.295N     P=0.168N     P=0.095N     P=0.317N   |
|INCIDENTAL TUMOR       |  P=0.151      P=0.265      P=0.463N     P=0.079    |  P=0.293N     P=0.187N     P=0.097N     P=0.356N   |
|LOGISTIC REGRESSION    |  P=0.250      P=0.245      P=0.454N     P=0.210    |  P=0.332N     P=0.198N     P=0.088N     P=0.373N   |
|COCHRAN-ARMITAGE       |  P=0.181                                           |  P=0.313N                                          |
|FISHER EXACT           |               P=0.245      P=0.500N     P=0.161    |               P=0.213N     P=0.100N     P=0.349N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  2/59 (3%)    1/60 (2%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         3.1%         0.0%         0.0%      |   5.8%         3.0%         2.4%         2.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/32 (0%)    1/32 (3%)    0/32 (0%)    0/43 (0%)  |  1/28 (4%)    1/33 (3%)    0/29 (0%)    0/32 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      ---          ---       |   623          735 (T)      665          664       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.519N     P=0.500        (e)          (e)      |  P=0.409N     P=0.465N     P=0.474N     P=0.499N   |
|INCIDENTAL TUMOR       |  P=0.519N     P=0.500        (e)          (e)      |  P=0.498N     P=0.444N     P=0.484N     P=0.641N   |
|LOGISTIC REGRESSION    |  P=0.519N     P=0.500        (e)          (e)      |  P=0.418N     P=0.489N     P=0.488N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.567N                                          |  P=0.405N                                          |
|FISHER EXACT           |               P=0.500        (e)          (e)      |               P=0.494N     P=0.494N     P=0.494N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE  16
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    4/60 (7%)    4/60 (7%)    2/60 (3%)  | 14/59 (24%)  18/60 (30%)  17/60 (28%)  15/60 (25%) |
|ADJUSTED (b)           |   8.9%        11.6%        10.6%         4.7%      |  37.8%        42.8%        42.3%        42.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/32 (6%)    2/32 (6%)    1/32 (3%)    2/43 (5%)  |  7/28 (25%)  10/33 (30%)   8/29 (28%)  12/32 (38%) |
|FIRST INCIDENCE (DAYS) |   714          700          644          733 (T)   |   457 (I)      369          552          444       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.243N     P=0.493      P=0.504      P=0.374N   |  P=0.486N     P=0.407      P=0.418      P=0.570N   |
|INCIDENTAL TUMOR       |  P=0.415N     P=0.559      P=0.531      P=0.442N   |  P=0.395      P=0.262      P=0.455      P=0.407    |
|LOGISTIC REGRESSION    |  P=0.293N     P=0.502      P=0.505      P=0.400N   |  P=0.487      P=0.292      P=0.411      P=0.454    |
|COCHRAN-ARMITAGE       |  P=0.368N                                          |  P=0.521N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.500N   |               P=0.286      P=0.358      P=0.521    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    3/60 (5%)    4/60 (7%)    2/60 (3%)  | 12/59 (20%)  17/60 (28%)  16/60 (27%)  14/60 (23%) |
|ADJUSTED (b)           |   8.9%         8.7%        10.6%         4.7%      |  33.3%        40.4%        40.9%        40.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  2/32 (6%)    1/32 (3%)    1/32 (3%)    2/43 (5%)  |  6/28 (21%)   9/33 (27%)   8/29 (28%)  12/32 (38%) |
|FIRST INCIDENCE (DAYS) |   714          700          644          733 (T)   |   457 (I)      369          552          444       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.292N     P=0.653      P=0.504      P=0.374N   |  P=0.525      P=0.318      P=0.330      P=0.513    |
|INCIDENTAL TUMOR       |  P=0.489N     P=0.605N     P=0.531      P=0.442N   |  P=0.352      P=0.177      P=0.363      P=0.368    |
|LOGISTIC REGRESSION    |  P=0.347N     P=0.662N     P=0.505      P=0.400N   |  P=0.418      P=0.215      P=0.311      P=0.368    |
|COCHRAN-ARMITAGE       |  P=0.421N                                          |  P=0.487                                           |
|FISHER EXACT           |               P=0.660N     P=0.500      P=0.500N   |               P=0.211      P=0.275      P=0.431    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE  17
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 26/60 (43%)  29/60 (48%)  28/60 (47%)  31/60 (52%) | 29/59 (49%)  27/60 (45%)  27/60 (45%)  19/60 (32%) |
|ADJUSTED (b)           |  61.7%        68.9%        68.8%        61.5%      |  73.4%        66.6%        65.6%        53.7%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   4/10 (40%)   3/10 (30%)   3/10 (30%) |  0/10 (0%)    2/10 (20%)   3/10 (30%)   1/10 (10%) |
|TERMINAL (d)           | 17/32 (53%)  20/32 (63%)  20/32 (63%)  24/43 (56%) | 18/28 (64%)  20/33 (61%)  16/29 (55%)  16/32 (50%) |
|FIRST INCIDENCE (DAYS) |   437          434          456 (I)      456 (I)   |   426          457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.315N     P=0.366      P=0.435      P=0.443N   |  P=0.021N*    P=0.223N     P=0.355N     P=0.019N*  |
|INCIDENTAL TUMOR       |  P=0.391      P=0.324      P=0.376      P=0.280    |  P=0.041N*    P=0.344N     P=0.332N     P=0.057N   |
|LOGISTIC REGRESSION    |  P=0.413      P=0.359      P=0.439      P=0.312    |  P=0.041N*    P=0.361N     P=0.313N     P=0.050N*  |
|COCHRAN-ARMITAGE       |  P=0.229                                           |  P=0.030N*                                         |
|FISHER EXACT           |               P=0.357      P=0.427      P=0.232    |               P=0.394N     P=0.394N     P=0.039N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 21/60 (35%)  27/60 (45%)  19/60 (32%)  18/60 (30%) | 24/59 (41%)  23/60 (38%)  27/60 (45%)  24/60 (40%) |
|ADJUSTED (b)           |  44.1%        54.8%        43.2%        37.4%      |  57.2%        51.2%        60.4%        60.3%      |
|INTERIM SACRIFICE 1 (c)|  3/10 (30%)   4/10 (40%)   0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  8/32 (25%)  11/32 (34%)   8/32 (25%)  13/43 (30%) | 11/28 (39%)  12/33 (36%)  12/29 (41%)  17/32 (53%) |
|FIRST INCIDENCE (DAYS) |   437          456 (I)      342          532       |   426          369          552          444       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.049N*    P=0.223      P=0.420N     P=0.142N   |  P=0.520N     P=0.346N     P=0.472      P=0.458N   |
|INCIDENTAL TUMOR       |  P=0.379N     P=0.173      P=0.405N     P=0.565    |  P=0.341      P=0.540N     P=0.458      P=0.489    |
|LOGISTIC REGRESSION    |  P=0.250N     P=0.166      P=0.424N     P=0.344N   |  P=0.339      P=0.461N     P=0.462      P=0.520    |
|COCHRAN-ARMITAGE       |  P=0.163N                                          |  P=0.508                                           |
|FISHER EXACT           |               P=0.176      P=0.423N     P=0.348N   |               P=0.470N     P=0.386      P=0.544N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 04                                                 PAGE  18
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      50 PPM       100 PPM      200 PPM   |   CONTROL      50 PPM       100 PPM      200 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 36/60 (60%)  44/60 (73%)  40/60 (67%)  38/60 (63%) | 36/59 (61%)  38/60 (63%)  40/60 (67%)  33/60 (55%) |
|ADJUSTED (b)           |  73.8%        84.1%        81.2%        72.8%      |  79.6%        78.7%        81.0%        78.0%      |
|INTERIM SACRIFICE 1 (c)|  4/10 (40%)   6/10 (60%)   3/10 (30%)   3/10 (30%) |  1/10 (10%)   2/10 (20%)   3/10 (30%)   1/10 (10%) |
|TERMINAL (d)           | 20/32 (63%)  24/32 (75%)  23/32 (72%)  29/43 (67%) | 19/28 (68%)  23/33 (70%)  20/29 (69%)  23/32 (72%) |
|FIRST INCIDENCE (DAYS) |   437          434          342          456 (I)   |   426          369          457 (I)      444       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.069N     P=0.156      P=0.343      P=0.192N   |  P=0.248N     P=0.438N     P=0.442      P=0.241N   |
|INCIDENTAL TUMOR       |  P=0.504      P=0.084      P=0.296      P=0.352    |  P=0.439N     P=0.428      P=0.428      P=0.517N   |
|LOGISTIC REGRESSION    |  P=0.422N     P=0.089      P=0.290      P=0.507    |  P=0.379N     P=0.486      P=0.422      P=0.453N   |
|COCHRAN-ARMITAGE       |  P=0.518N                                          |  P=0.255N                                          |
|FISHER EXACT           |               P=0.087      P=0.285      P=0.426    |               P=0.471      P=0.326      P=0.316N   |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   456
          Female interim sacrifices(days): 457
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).