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TDMS Study 05133-04 Pathology Tables

NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05




       Facility:  Battelle Northwest

       Chemical CAS #:  75-05-8

       Lock Date:  07/17/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|             
                                           | 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X                                                              X|             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                              X                           |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     | 2           2                                            2               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                   1                                      1               |             
      Bile Duct, Cyst                      |                               X                                          |             
      Bile Duct, Degeneration              |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +              +                 +                        |             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic                |                2                                                         |             
      Fat, Necrosis                        |       4                                         3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                1         |             
      Focal Cellular Change                |                                                                   1      |             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Inflammation, Chronic                |       4  1                                                               |             
      Duct, Ectasia                        |          3                                                              4|             
      Duct, Inflammation, Chronic          |                                                                         3|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Squamous                |       3                                                                  |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|             
                                           | 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                      1                       1  1  1           2         |             
      Hyperplasia, Atypical                |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                      1           2                                       |             
      Hypertrophy                          |                                        1                                 |             
      Capsule, Hyperplasia                 |                                           4                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2        1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                      X   |             
      Pars Distalis, Hyperplasia           |                1  1                 1        1              2     1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                            X                                             |             
      Follicular Cell, Hyperplasia         | 1                    2                 4           1  1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  M  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  M  M  +  +|             
      Atrophy                              |                                                             4            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                                     1                                    |             
      Atrophy                              |             3  2        2  2        2           2     1  2     4         |             
      Cyst                                 |    X        X              X  X                 X  X  X  X  X            |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|             
                                           | 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Hyperplasia, Cystic                  | 2  2  1  3  3  4  2  4  3  2  2  1  3  2  3  2  3  3  3  1  1  3  4  2  3|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |       3     3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +              +        +            |             
      Iliac, Hyperplasia                   |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                            2                 2  2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +     +  M  M  +  +  +  M  +  +  M  +  +  M  +  M|             
      Hyperplasia                          |    2                                         3        2        2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                          3               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Histiocytic             |                            4                                             |             
      Hyperplasia                          |       2                                                                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  M  M  +  +  M  +  +  +  I  +  +  +  M  +  M  M  +  +  M  +  M|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |       2     2                                            3               |             
      Hemorrhage                           | 3                                                                        |             
      Hyperplasia, Lymphoid                |                2     2     2        2           2     2        4         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                                          3               |             
      Hyperplasia, Lymphoid                |                2     2                    2                       4      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                      2              3     3        1  1     1  1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|             
                                           | 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        1                                 |             
      Inflammation                         |                                                                          |             
      Mineralization                       |             1  1        1                 1     1  1  1  2  2           1|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                1            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   1     1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Mediastinum, Inflammation    |                                                                          |             
      Mediastinum, Hemorrhage              |                            3                                             |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                1         |             
      Olfactory Epithelium, Atrophy        |                         2                                                |             
      Olfactory Epithelium, Metaplasia     |                         1                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hyperplasia, Atypical                |             2                                                            |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |       1  1  1        1                 1     1  1     1        1  1      |             
      Arteriole, Inflammation, Chronic     |                                                                2         |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Pigmentation, Hemosiderin    |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 4| 7| 7| 4| 7| 6| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 5|             
                             DAY ON TEST   | 8| 3| 2| 5| 3| 3| 5| 3| 6| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 6|             
                                           | 1| 5| 6| 7| 5| 5| 7| 5| 4| 4| 7| 7| 5| 5| 5| 5| 5| 5| 5| 2| 0| 5| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                  2                                       |             
      Ulcer                                |                                                                          |             
      Arteriole, Inflammation              |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|             
                             DAY ON TEST   | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|             
                                           | 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                   1                                                      |             
      Necrosis                             |                   1                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                   2                                                      |             
      Necrosis                             |                   1                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Basophilic Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                   2      |             
      Eosinophilic Focus                   | X        X           X                                               X   |             
      Focal Cellular Change                |                         X                                                |             
      Hematopoietic Cell Proliferation     |                               3  1                          3  2  2      |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Infarct                              |                                                             4            |             
      Mixed Cell Focus                     |                      X  X           X              X                     |             
      Necrosis                             |                                                    1                     |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Degeneration              |                                                                2         |             
      Centrilobular, Necrosis              |             3                                                            |             
      Serosa, Inflammation, Suppurative    |                               4  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +  +              +        +           +         |             
      Angiectasis                          |                                                    2                     |             
      Inflammation, Chronic                |                                           3                              |             
      Fat, Necrosis                        |    3                    3  2                       2           1         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |                                                                4         |             
      Focal Cellular Change                |    1                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        |                         4                                                |             
      Duct, Inflammation, Chronic          |                                                                2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                              1                           |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|             
                             DAY ON TEST   | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|             
                                           | 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Suppurative            |                                                                2         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy                       | 1  1     1     1              1        2  1           1                  |             
      Hyperplasia, Atypical                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                               2                             2            |             
      Hyperplasia                          |                                  3                                       |             
      Hypertrophy                          |                                              1                           |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                     1                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  M  M  +  M  +  M  M  M  M  +  M  M  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Cyst                  |    X                                         X              X            |             
      Pars Distalis, Hyperplasia           |    4           1     2                 3     2        1     2     1  2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         | 1           1  1        1           3                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  M  M  +  M  +  +  M  +  +   |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Abscess                              |                               4  4                          4     4      |             
      Amyloid Deposition                   |                   2                                                      |             
      Angiectasis                          |                   4                                                  3   |             
      Atrophy                              |          2  2        1  1     2     2                                1   |             
      Cyst                                 |          X                       X        X           X  X               |             
      Mineralization                       |                                                                      3   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|             
                             DAY ON TEST   | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|             
                                           | 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Amyloid Deposition                   |                   1                                                      |             
      Hyperplasia, Cystic                  | 3  3  2  2  2  2  3  2  2  2     2  2  2  2  2  2  2  3     4  2  2  3   |             
      Inflammation, Suppurative            |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Neutrophil              |                         2     2                             2     2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                             +  +         |             
      Iliac, Hyperplasia                   |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  M  +  M  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                                                             2     2      |             
      Hyperplasia                          |    2           2     2        2           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  M  +   |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                      2   |             
      Congestion                           |                   2                                                      |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia                          |                                                                      2   |             
      Inflammation, Chronic                |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                                                             2     2      |             
      Hyperplasia                          |          2                    2  3           2              3        2   |             
      Inflammation, Suppurative            |                               3  3                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |                                                                      3   |             
      Hematopoietic Cell Proliferation     | 2        1                    4  2  1     2  1              4            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2                 2  2                 1           1                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +   |             
      Atrophy                              |             2                 3  3                          2            |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                        1                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Fibrous Osteodystrophy               |             2     2  2  2  2     1  1  1  2  2        2     1     2  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|             
                             DAY ON TEST   | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|             
                                           | 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |          1  1  2     2  1        2  1  1  1        1     1  1  1  1  1   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |             1                             1                              |             
      Inflammation, Acute                  |                                                             2            |             
      Inflammation, Suppurative            |                                  1                                       |             
      Thrombosis                           |             1                                                            |             
      Alveolar Epithelium, Hyperplasia     |                         1                                                |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                3         |             
      Artery, Mediastinum, Inflammation    |                                                                          |             
      Mediastinum, Hemorrhage              |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                               4                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                2                                2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Suppurative            |                      1                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Atrophy        | 1  1           2                                   1                     |             
      Olfactory Epithelium, Metaplasia     | 1  1           2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Amyloid Deposition                   |                   4                                                      |             
      Hyperplasia, Atypical                |                                                                          |             
      Inflammation, Suppurative            |                                                             3            |             
      Nephropathy                          | 1  1     2  1        1           1  1  1  2        1                     |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Pigmentation, Hemosiderin    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 7| 7| 7| 4| 6| 7| 4| 6| 5| 6| 7| 0|             
                             DAY ON TEST   | 3| 3| 5| 0| 1| 3| 1| 3| 8| 5| 5| 4| 3| 3| 3| 3| 5| 3| 3| 5| 7| 8| 9| 0| 0|             
                                           | 5| 5| 7| 6| 0| 5| 7| 5| 1| 7| 8| 1| 5| 5| 5| 5| 7| 5| 5| 7| 8| 1| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                3         |             
      Arteriole, Inflammation              |                                                                3         |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0|                                            |            |
                                           | 3| 7| 5| 5| 5| 5| 6| 5| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  M  +  +  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  M                                             |  56        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  +  +                                             |  55        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +                                             |  54        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Basophilic Focus                     |                                                                          |      2     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      5     |
      Focal Cellular Change                |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      8  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Mixed Cell Focus                     |                                                                          |      4     |
      Necrosis                             | 3        1                                                               |      5  1.4|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Degeneration              |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  10        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Fat, Necrosis                        |                                                                          |      7  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      2  2.5|
      Focal Cellular Change                |                                                                          |      2  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                            1                                             |      3  2.0|
      Duct, Ectasia                        |                                                                          |      3  3.7|
      Duct, Inflammation, Chronic          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0|                                            |            |
                                           | 3| 7| 5| 5| 5| 5| 6| 5| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hyperplasia, Squamous                |                   4                                                      |      2  3.5|
      Inflammation, Suppurative            |                   1                                                      |      1  1.0|
      Ulcer                                |                   1                                                      |      1  1.0|
      Epithelium, Hyperplasia              |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  M  +  M  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cardiomyopathy                       |       1  1  1                                                            |     16  1.1|
      Hyperplasia, Atypical                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia                          |                   3                                                      |      4  2.3|
      Hypertrophy                          |                            1                                             |      3  1.0|
      Capsule, Hyperplasia                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  M  M                                             |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +                                             |  58        |
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia           | 1  1  4                 2                                                |     19  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                1     1                                                   |     12  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0|                                            |            |
                                           | 3| 7| 5| 5| 5| 5| 6| 5| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  M  +  M  +  +  M  +  M                                             |  40        |
      Atrophy                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +  +  +  +  +  +                                             |  58        |
      Abscess                              |                                                                          |      4  4.0|
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      3  2.7|
      Atrophy                              |       3                                                                  |     17  2.0|
      Cyst                                 |    X           X     X  X  X                                             |     19     |
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  1.0|
      Hyperplasia, Cystic                  | 2  2  3  2  2  2  2  2  2  2                                             |     57  2.4|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Neutrophil              |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                    +                                                   |   7        |
      Iliac, Hyperplasia                   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  M  +  +  +                                             |  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia                          |    2  1     3                                                            |     11  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  +  +  +                                             |  42        |
      Hyperplasia                          |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M                                             |  54        |
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  4.0|
      Hyperplasia                          |                         2                                                |      3  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  +                                             |  43        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      6  2.3|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |          4                                                               |     12  2.3|
      Hemorrhage                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0|                                            |            |
                                           | 3| 7| 5| 5| 5| 5| 6| 5| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |       1                                                                  |     14  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  M                                             |  54        |
      Atrophy                              |                                                                          |      5  2.6|
      Hyperplasia, Lymphoid                |          3                                                               |      6  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrous Osteodystrophy               |       2        3     1  2  1                                             |     27  1.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation                         |                   2                                                      |      1  2.0|
      Mineralization                       | 1        1           1                                                   |     28  1.2|
      Necrosis                             |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      4  1.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
      Artery, Mediastinum, Inflammation    |             4                                                            |      1  4.0|
      Mediastinum, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  4.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 5| 3| 3| 3| 3| 2| 3| 3| 0|                                            |            |
                                           | 3| 7| 5| 5| 5| 5| 6| 5| 5| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      5  1.4|
      Olfactory Epithelium, Metaplasia     |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                    +                                                   |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Hyperplasia, Atypical                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nephropathy                          |       1     1  1        1                                                |     24  1.1|
      Arteriole, Inflammation, Chronic     |                                                                          |      1  2.0|
      Cortex, Cyst                         |                   3                                                      |      1  3.0|
      Cortex, Pigmentation, Hemosiderin    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Arteriole, Inflammation              |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 8| 5| 7| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| 3|             
                                           | 7| 6| 7| 9| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 8| 7| 6| 6| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 PPM                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        1           1                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X                                                |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                  X                                       |             
      Cytomegaly                           |                                                       4                  |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                      X                       X                           |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Karyomegaly                          |                                                       3                  |             
      Mixed Cell Focus                     |                                              X  X                        |             
      Necrosis                             |          1                                                               |             
      Pigmentation, Hemosiderin            |                                  2                                       |             
      Regeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +  +  +  +        +              +  +                 +   |             
      Fat, Necrosis                        |                2  3              3              4                    3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Atrophy                              |                      3                                                   |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia                          |                                              1                           |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Hyperplasia, Squamous                |    2                                2     4        4                    2|             
      Inflammation, Suppurative            |    1                                      3                              |             
      Ulcer                                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                       2                  |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 8| 5| 7| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| 3|             
                                           | 7| 6| 7| 9| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 8| 7| 6| 6| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 PPM                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1           1     1  1              1     1  1              1     1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                2                             1                           |             
      Hypertrophy                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        1     4                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                                1     1            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  M  M  M  +  M  +  +  M  M  +  M  +  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |          X                                                     X         |             
      Pars Distalis, Hyperplasia           |          1              1                    2              2  2     2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              1                           |             
      Follicle, Cyst                       |                                              X                           |             
      Follicular Cell, Hyperplasia         |    1           1                 1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  M  M  +  +  +  M  +  +  M  +  M  M  +  M  +  M  M  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                       2                  |             
      Angiectasis                          |                         2                                                |             
      Atrophy                              |          3              1  1  1  1  1        1        2     2     3  2   |             
      Cyst                                 |       X  X                    X  X  X           X  X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia, Cystic                  |    2  2  3  1     3  2  3  4  3  2  2  3  2  2  2     2  4  2  2  3  3  3|             
      Myometrium, Hyperplasia              |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 8| 5| 7| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| 3|             
                                           | 7| 6| 7| 9| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 8| 7| 6| 6| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 PPM                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +        +                 +                                   +|             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia                   |                                     2                                    |             
      Renal, Congestion                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  M  +  M  +  +  M  +  M  +  +  I  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                                     |             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                  2  2                          2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  M  +  +  +  M  M  +  M  M  M  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   2                                                      |             
      Hematopoietic Cell Proliferation     |    2              4                       2        2                 2   |             
      Hyperplasia, Lymphoid                |                2     2     2  1     2  2     2              2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                2  2  4   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                1        2        3        1           1        1     2  3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
      Inflammation                         |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |    1     1        1     1  1  1  1  1        1  1  1     2  1  1  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 5| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 8| 5| 7| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| 3|             
                                           | 7| 6| 7| 9| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 9| 8| 7| 6| 6| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    50 PPM                                 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus                              |                                                          X               |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               2  1           2                           |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               3  1  1                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2                                2                                    |             
      Olfactory Epithelium, Atrophy        |    1                                               1                     |             
      Olfactory Epithelium, Metaplasia     |    1                                               1                     |             
      Olfactory Epithelium, Necrosis       |          3                                                               |             
      Respiratory Epithelium, Necrosis     |          3                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          2                                            3                  |             
      Hydronephrosis                       |                   1                                                      |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Metaplasia, Osseous                  |                      1                                               1   |             
      Nephropathy                          |       1              1  2  1  1  1  1  1  1  2  1     4     1  1     1  1|             
      Cortex, Pigmentation, Hemosiderin    |                                                                          |             
      Glomerulus, Embolus                  |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 6| 4| 6| 7| 4| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 0| 4| 5| 2| 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 6| 6| 5| 6| 2| 6| 7| 2| 6| 5| 6| 7| 7| 6| 6| 6| 5| 6| 6| 7| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 PPM                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                          X               |             
      Clear Cell Focus                     |       X                                                                  |             
      Cyst                                 |                                                                          |             
      Cytomegaly                           |                                                                          |             
      Degeneration, Fatty                  |                   2                                                      |             
      Eosinophilic Focus                   |                                                          X               |             
      Hematopoietic Cell Proliferation     |                   3                                                      |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                  2           2                           |             
      Karyomegaly                          |                                                                          |             
      Mixed Cell Focus                     |             X                                                            |             
      Necrosis                             |                               1                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Regeneration                         |                         3                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +           +                    +     +               |             
      Fat, Necrosis                        |          3        4                                      3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                   3                                                      |             
      Atrophy                              |                   4                                                      |             
      Focal Cellular Change                |       1                                                                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                1                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                             2            |             
      Hyperplasia, Squamous                |    1                 4                                                   |             
      Inflammation, Suppurative            |    1                                                                     |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                            2                                             |             
      Mineralization                       |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 6| 4| 6| 7| 4| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 0| 4| 5| 2| 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 6| 6| 5| 6| 2| 6| 7| 2| 6| 5| 6| 7| 7| 6| 6| 6| 5| 6| 6| 7| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 PPM                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             1  1           1     1           1        1  1               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                      X                 X      |             
      Hematopoietic Cell Proliferation     |                   1     2                                                |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          | 1        1                                                     1         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1     2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  +  +  M  +  +  M  M  +  +  M  M  M  +  +  +  M  M  M  M  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       3  1                 2     2              4  1  4        4         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |    2                             2                             2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                   2  2           1        2              1               |             
      Cyst                                 |          X        X  X              X     X     X     X              X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          4                 4                                             |             
      Hyperplasia, Cystic                  | 4  2  2  3  2  1     3  2        2  2  2  2  3  4  2  2  3  2  1  3  2  2|             
      Myometrium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 6| 4| 6| 7| 4| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 0| 4| 5| 2| 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 6| 6| 5| 6| 2| 6| 7| 2| 6| 5| 6| 7| 7| 6| 6| 6| 5| 6| 6| 7| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 PPM                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +  +                                   +      |             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia                   |                                                                          |             
      Renal, Congestion                    |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                               2                                          |             
      Hyperplasia                          |                   3                          2              3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  I  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                   3                                                      |             
      Hyperplasia                          |                                                    3  2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  M  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Erythrophagocytosis                  |                               2                                          |             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                   3     4     2                    2           1         |             
      Hyperplasia, Lymphoid                | 2     2                          2           3              2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Atrophy                              |                   3                                                      |             
      Developmental Malformation           |                         X                                                |             
      Hyperplasia, Lymphoid                |                                  2              2                        |             
      Necrosis                             |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 1  1     2                 1     1           2  1     2                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          1                                                               |             
      Mineralization                       | 1  1  1  1  1           1        1           2  1              1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 6| 6| 4| 6| 7| 4| 7| 4| 4| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 0| 4| 5| 2| 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 6| 6| 5| 6| 2| 6| 7| 2| 6| 5| 6| 7| 7| 6| 6| 6| 5| 6| 6| 7| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 PPM                                 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus                              |                                                                          |             
      Hemorrhage                           |                      1                                                   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                              3                           |             
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                           1           1                  |             
      Olfactory Epithelium, Metaplasia     |                                           1                              |             
      Olfactory Epithelium, Necrosis       |                                                                          |             
      Respiratory Epithelium, Necrosis     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                         4                                                |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                  2                                       |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1     1     1              1              1  1  1     1  1        1  1  1|             
      Cortex, Pigmentation, Hemosiderin    |                               2                                          |             
      Glomerulus, Embolus                  |                2                                                         |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 3| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5|                                            |            |
                                           | 6| 6| 6| 4| 7| 7| 9| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50 PPM                                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  A  +  +  +                                             |  55        |
      Inflammation, Suppurative            |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  M  +  A  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  A  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |             X                                                            |      3     |
      Clear Cell Focus                     |                                                                          |      1     |
      Cyst                                 |                                                                          |      1     |
      Cytomegaly                           |                                                                          |      1  4.0|
      Degeneration, Fatty                  |                         3                                                |      2  2.5|
      Eosinophilic Focus                   |                                                                          |      3     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      2  2.0|
      Karyomegaly                          |                                                                          |      1  3.0|
      Mixed Cell Focus                     |       X                                                                  |      4     |
      Necrosis                             |    1        2                                                            |      4  1.3|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Regeneration                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +                                                            |  16        |
      Fat, Necrosis                        |    2                                                                     |      9  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      2  3.5|
      Focal Cellular Change                |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Diverticulum                         |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                         3                                                |      8  2.8|
      Inflammation, Suppurative            |                                                                          |      3  1.7|
      Ulcer                                |                         1                                                |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 3| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5|                                            |            |
                                           | 6| 6| 6| 4| 7| 7| 9| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50 PPM                                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  M  +  +  +                                             |  53        |
      Mineralization                       |                      2                                                   |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 1  1     1                                                               |     19  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  A  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      3     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Hyperplasia                          |                                                                          |      2  1.5|
      Hypertrophy                          |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  A  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | I  M  +  +  +  +  M  +  +  M                                             |  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  A  +  +  +                                             |  59        |
      Pars Distalis, Cyst                  |                      X                                                   |      3     |
      Pars Distalis, Hyperplasia           |    2                    1                                                |     16  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  A  +  +  +                                             |  58        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +                                             |  41        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  A  +  M  +                                             |  57        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 3| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5|                                            |            |
                                           | 6| 6| 6| 4| 7| 7| 9| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50 PPM                                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |    2  2     1                                                            |     19  1.6|
      Cyst                                 | X        X     X                                                         |     18     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  A  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      2  4.0|
      Hyperplasia, Cystic                  | 4  3  4  2  2  3     4  3  1                                             |     53  2.5|
      Myometrium, Hyperplasia              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +                                             |  59        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +                                                            |   9        |
      Iliac, Hemorrhage                    |       4                                                                  |      1  4.0|
      Iliac, Hyperplasia                   |                                                                          |      1  2.0|
      Renal, Congestion                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  A  M  I  +                                             |  54        |
      Erythrophagocytosis                  |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  M  +  M  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +                                             |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  M  A  +  M  +                                             |  43        |
      Erythrophagocytosis                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +  +  +                                             |  59        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |       2  3                                                               |     12  2.4|
      Hyperplasia, Lymphoid                | 1  2                                                                     |     15  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  A  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              |                         2                                                |      2  2.5|
      Developmental Malformation           |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.4|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +                                             |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 3| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5|                                            |            |
                                           | 6| 6| 6| 4| 7| 7| 9| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50 PPM                                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               | 1  2                                                                     |     18  1.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mineralization                       |                1     1  1  1                                             |     31  1.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  A  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Embolus                              |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      4  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      3  1.0|
      Olfactory Epithelium, Necrosis       |                                                                          |      1  3.0|
      Respiratory Epithelium, Necrosis     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  A  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 3| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 6| 1| 5| 6| 1| 2| 5|                                            |            |
                                           | 6| 6| 6| 4| 7| 7| 9| 1| 1| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    50 PPM                                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Amyloid Deposition                   |                                                                          |      2  2.5|
      Hydronephrosis                       |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
      Metaplasia, Osseous                  | 1                                                                        |      3  1.0|
      Nephropathy                          | 1  1  1  2                                                               |     32  1.2|
      Cortex, Pigmentation, Hemosiderin    |                                                                          |      1  2.0|
      Glomerulus, Embolus                  |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +                                             |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6|             
                             DAY ON TEST   | 0| 3| 8| 3| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 5| 0| 3| 2| 5| 5| 3| 5|             
                                           | 6| 4| 3| 6| 2| 6| 6| 6| 7| 6| 0| 6| 6| 6| 3| 6| 6| 7| 4| 6| 7| 7| 7| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  I  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  I  +  +  A  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |                               2                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Focal Cellular Change                |    1           X                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Mitotic Alteration                   |                                     1                                    |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             | 2                                               2     1                  |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                   +        +     +  +                  |             
      Fat, Necrosis                        |                                     3        2     2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Inflammation, Chronic                |                                              2                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                               4        4  3                              |             
      Inflammation, Suppurative            |                                        2  2                              |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cardiomyopathy                       |    1        1     1  1        1  1           1        1              1   |             
      Hyperplasia, Atypical                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6|             
                             DAY ON TEST   | 0| 3| 8| 3| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 5| 0| 3| 2| 5| 5| 3| 5|             
                                           | 6| 4| 3| 6| 2| 6| 6| 6| 7| 6| 0| 6| 6| 6| 3| 6| 6| 7| 4| 6| 7| 7| 7| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypertrophy                          |             1  1  1                 1                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               4     1                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  M  M  M  M  +  +  M  +  M  M  +  M  +  +  +  +  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 3  1     1     4  2  2     1     1              2        2           3  3|             
      Pars Intermedia, Hyperplasia         |    1                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                1                             1           1           1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  M  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |    2                             3  2  2     2           2  2        2   |             
      Cyst                                 |                   X        X     1              X     X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Dilatation                           |                                                                          |             
      Hyperplasia, Cystic                  | 2  1  3  4  2  2  4  4  2  2  2  3  4  2  3  3  2  2  3  1  3  1     3  2|             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                           +           +|             
      Axillary, Hyperplasia                |                                                                          |             
      Iliac, Hyperplasia                   |                                                                          |             
      Popliteal, Hyperplasia               |                                                             2            |             
      Renal, Angiectasis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                               2           2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6|             
                             DAY ON TEST   | 0| 3| 8| 3| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 5| 0| 3| 2| 5| 5| 3| 5|             
                                           | 6| 4| 3| 6| 2| 6| 6| 6| 7| 6| 0| 6| 6| 6| 3| 6| 6| 7| 4| 6| 7| 7| 7| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Hyperplasia                          |          2                          4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |          1                             2                       1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  M  +  M  M  M  +  M|             
      Hyperplasia                          |          2  2        2           3                       2           2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |          2  1  2                       2     2        3                  |             
      Hyperplasia, Lymphoid                |          2     2  2  2              3           2        2               |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                                      |             
      Atrophy                              |                                                       1                  |             
      Hyperplasia, Lymphoid                |          2        2              4                                   2   |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Hyperplasia         |                                                                      4   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                      2           2           2  1                    1   |             
      Fracture                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2           2        1        1     1  1  1     2     1  1              1|             
      Pigmentation, Hemosiderin            |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6|             
                             DAY ON TEST   | 0| 3| 8| 3| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 6| 3| 3| 5| 0| 3| 2| 5| 5| 3| 5|             
                                           | 6| 4| 3| 6| 2| 6| 6| 6| 7| 6| 0| 6| 6| 6| 3| 6| 6| 7| 4| 6| 7| 7| 7| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |             3  2                                                         |             
      Arteriole, Inflammation              |             3                                                            |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                  1                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                  1     1                                2|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                         1|             
      Respiratory Epithelium, Necrosis     |                                                                         1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |       1                                                                  |             
      Nephropathy                          |          1  1  1     1     1     1     1     1  1        1     1     1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 0| 7| 3| 6| 5| 3| 5| 3| 3| 3| 5| 7| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 6| 7| 8| 0| 6| 5| 2| 6| 7| 5| 6| 6| 7| 1| 6| 6| 3| 6| 6| 7| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  A  M  +  +  +  M  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1                                    |             
      Inflammation, Suppurative            |                            2                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                           4                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Clear Cell Focus                     |                                                                X         |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |                                                 X                 X      |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Mitotic Alteration                   |                                     2                                    |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                1  1  4           1        1                              |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +  +                     |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          1               |             
      Focal Cellular Change                |                                                 1     1                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |          1     2                    1              1           1         |             
      Inflammation, Suppurative            |                2                                                         |             
      Necrosis                             |                1                                                         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cardiomyopathy                       | 1  1           1  1        1  1     1     1                    1     1  1|             
      Hyperplasia, Atypical                |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 0| 7| 3| 6| 5| 3| 5| 3| 3| 3| 5| 7| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 6| 7| 8| 0| 6| 5| 2| 6| 7| 5| 6| 6| 7| 1| 6| 6| 3| 6| 6| 7| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Hypertrophy                          |                                                 1     1                 1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           1                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  M  M  +  M  +  +  M  M  M  M  M  M  +  +  M  +  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia           |                2           2     1           1           1  1  1        3|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 3  1                                2                 2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  M  +  M  M  +  M  +  M  +  +  +  +  +  +  M  +  +  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2              1                     |             
      Atrophy                              |    3           1  1              2                 1  1        1     2   |             
      Cyst                                 |    X              X  X        X              X           X  X           X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Dilatation                           |                                                                          |             
      Hyperplasia, Cystic                  | 2     1  2     4  1  2  3  4  4  3  2  2  2  4  3  3  3     2  3  3  2  2|             
      Inflammation, Suppurative            |                                              3                           |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                     4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                                         +                 +|             
      Axillary, Hyperplasia                |                                                       1                  |             
      Iliac, Hyperplasia                   |                                                                          |             
      Popliteal, Hyperplasia               |                                                                          |             
      Renal, Angiectasis                   |                                                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                2  4                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 0| 7| 3| 6| 5| 3| 5| 3| 3| 3| 5| 7| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 6| 7| 8| 0| 6| 5| 2| 6| 7| 5| 6| 6| 7| 1| 6| 6| 3| 6| 6| 7| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          | 2                                2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |             3                                                            |             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |             3                                                            |             
      Hyperplasia                          | 2              3  3        1                    2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  M  +  M  +  +|             
      Hyperplasia                          | 4                                                                    3   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |             4                                                            |             
      Hematopoietic Cell Proliferation     | 2              1  3                 3     2                    1         |             
      Hyperplasia, Lymphoid                | 3                 2              2           3           2           1   |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                   2              2           2        2              2  2|             
      Epithelial Cell, Hyperplasia         |                                                 1     2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    2     2        1                          2        2  2     1  1      |             
      Fracture                             |                                                                X         |             
      Inflammation, Chronic                |                                                                2         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Hemorrhage                           |                                                                2         |             
      Inflammation                         |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    1     1  1  1  1  1  1        1     2           1  1  2        1     1|             
      Pigmentation, Hemosiderin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 6| 5| 7| 4| 6| 7| 7| 4| 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 0| 7| 3| 6| 5| 3| 5| 3| 3| 3| 5| 7| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3|             
                                           | 6| 6| 7| 8| 0| 6| 5| 2| 6| 7| 5| 6| 6| 7| 1| 6| 6| 3| 6| 6| 7| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      2                 1                    1            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Arteriole, Inflammation              |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                                          1              2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                         1|             
      Olfactory Epithelium, Atrophy        |                                  1  1                                    |             
      Olfactory Epithelium, Metaplasia     |                                  1  1                                    |             
      Respiratory Epithelium, Hyperplasia  |             1                                                            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Respiratory Epithelium, Necrosis     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1                 1                 1     1  1  1        1     1     1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        1                                2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 7| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0|                                            |            |
                                           | 6| 0| 8| 9| 7| 6| 6| 7| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  I  +  +  +  +  +  +                                             |  51        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                X                                                         |      3     |
      Focal Cellular Change                |                                                                          |      2  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Mitotic Alteration                   |                                                                          |      2  1.5|
      Mixed Cell Focus                     |                         X                                                |      1     |
      Necrosis                             |                                                                          |      8  1.6|
      Centrilobular, Necrosis              |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Fat, Necrosis                        |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  1.0|
      Focal Cellular Change                |                                                                          |      2  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Squamous                |                4                                                         |      9  2.3|
      Inflammation, Suppurative            |                2                                                         |      4  2.0|
      Necrosis                             |                                                                          |      1  1.0|
      Ulcer                                |                2        1                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  M  +  +                                             |  55        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 7| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0|                                            |            |
                                           | 6| 0| 8| 9| 7| 6| 6| 7| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                   1                                                      |      1  1.0|
      Cardiomyopathy                       |       1        1  1                                                      |     23  1.0|
      Hyperplasia, Atypical                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hypertrophy                          |                                                                          |      7  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |    3     1  1        2                                                   |     24  1.8|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Hyperplasia         |          1                                                               |      9  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      2  1.5|
      Atrophy                              | 2  3     2        3                                                      |     20  2.0|
      Cyst                                 | X              X  X  X  X                                                |     18  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Dilatation                           |                            4                                             |      1  4.0|
      Hyperplasia, Cystic                  | 4  1  3  3  1  3  2  2  3                                                |     55  2.5|
      Inflammation, Suppurative            |                            2                                             |      2  2.5|
      Thrombosis                           |                   4                                                      |      1  4.0|
      Artery, Inflammation, Chronic        |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 7| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0|                                            |            |
                                           | 6| 0| 8| 9| 7| 6| 6| 7| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Neutrophil              |                            3                                             |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +           +                                             |   9        |
      Axillary, Hyperplasia                |                                                                          |      1  1.0|
      Iliac, Hyperplasia                   |                            3                                             |      1  3.0|
      Popliteal, Hyperplasia               |                                                                          |      1  2.0|
      Renal, Angiectasis                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M                                             |  51        |
      Hyperplasia                          | 2  1                                                                     |      7  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Hyperplasia                          |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Angiectasis                          |             1           2                                                |      2  1.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                   2                                                      |      9  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  +                                             |  44        |
      Hyperplasia                          | 2                 3                                                      |     10  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |    2  1                    2                                             |     15  1.9|
      Hyperplasia, Lymphoid                |                                                                          |     13  2.2|
      Capsule, Fibrosis                    |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +                                             |  56        |
      Angiectasis                          |                         2                                                |      2  2.0|
      Atrophy                              |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |    1              2                                                      |     12  2.1|
      Epithelial Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sebaceous Gland, Hyperplasia         |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 7| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0|                                            |            |
                                           | 6| 0| 8| 9| 7| 6| 6| 7| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |    1  1           1                                                      |     16  1.5|
      Fracture                             |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       | 2     1  1                                                               |     28  1.2|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |       2                                                                  |      5  1.4|
      Alveolar Epithelium, Hyperplasia     |                2           1                                             |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.5|
      Arteriole, Inflammation              |                2                                                         |      2  2.5|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                         1                                                |      2  1.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      5  1.2|
      Olfactory Epithelium, Metaplasia     |                                                                          |      2  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
      Respiratory Epithelium, Necrosis     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6| 7| 4| 7| 7| 4| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 7| 6| 1| 5| 3| 3| 5| 6| 0|                                            |            |
                                           | 6| 0| 8| 9| 7| 6| 6| 7| 4| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    100 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          | 1  2  2        1  1                                                      |     27  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 2| 7| 4| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 5| 3| 5| 3| 3| 3| 3| 5| 4| 5| 3| 3| 9| 9| 3| 5| 3| 1| 3| 7| 3|             
                                           | 5| 0| 5| 7| 7| 5| 7| 5| 5| 5| 5| 7| 4| 0| 5| 5| 1| 4| 5| 7| 5| 0| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 1                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |       X                                                                  |             
      Hematopoietic Cell Proliferation     |                                                                      1   |             
      Infarct                              |                                                                          |             
      Karyomegaly                          |                                                                          |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis                             |                                                                2         |             
      Bile Duct, Cyst                      |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                         +                        |             
      Fat, Necrosis                        |       3                                         2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                      2  2                          2                     |             
      Hyperplasia, Squamous                |                   2                 4  3        3     4     3  2     4   |             
      Inflammation, Suppurative            |                                                       3     2  2         |             
      Ulcer                                |                                                       2     2  1         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1           1  1           1                       1      |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        X                                 |             
      Hypertrophy                          |                                                             1            |             
      Capsule, Hyperplasia                 |                      3                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 2| 7| 4| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 5| 3| 5| 3| 3| 3| 3| 5| 4| 5| 3| 3| 9| 9| 3| 5| 3| 1| 3| 7| 3|             
                                           | 5| 0| 5| 7| 7| 5| 7| 5| 5| 5| 5| 7| 4| 0| 5| 5| 1| 4| 5| 7| 5| 0| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        4                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  M  +  M  +  +  +  +  M  +  +  +  +  +  M  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 1                          2        1     1     4     2     2        1  4|             
      Pars Distalis, Inflammation, Chronic |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                2  2  2        3                 2|             
      Cyst                                 | X              X     X     X  X                                   X      |             
      Germinal Epithelium, Hyperplasia     |                               3                                          |             
      Interstitium, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   1                                                      |             
      Hyperplasia, Cystic                  | 3  3  2  2  1  4  2  2  3  4  2     3  2  3  1  1     2  1  1  2  2  2   |             
      Inflammation, Suppurative            |                                                                          |             
      Arteriole, Hypertrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  M  +  M  M  +  +  M  +  M  +  +  M  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                   2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                 1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  I  +  M  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  M  +|             
      Hyperplasia                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 2| 7| 4| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 5| 3| 5| 3| 3| 3| 3| 5| 4| 5| 3| 3| 9| 9| 3| 5| 3| 1| 3| 7| 3|             
                                           | 5| 0| 5| 7| 7| 5| 7| 5| 5| 5| 5| 7| 4| 0| 5| 5| 1| 4| 5| 7| 5| 0| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                         1  2                 3                       2   |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                        1                                 |             
      Hyperplasia, Lymphoid                |                               1                       1     1            |             
      Necrosis                             |                                                    2                     |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    2                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                4        2           1     2           2     2     2      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Hemorrhage                           |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    2                     |             
      Inflammation, Chronic                |    2  2                                                                  |             
      Mineralization                       |    1  1        1        1           2  1                          1     1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    3                                                                     |             
      Inflammation, Acute                  |                         2                                                |             
      Thrombosis                           |       1                                            2                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         2                                                |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                            3                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                    2                     |             
      Olfactory Epithelium, Atrophy        |       1                                                           1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 4| 7| 4| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 2| 7| 4| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 5| 3| 5| 3| 3| 3| 3| 5| 4| 5| 3| 3| 9| 9| 3| 5| 3| 1| 3| 7| 3|             
                                           | 5| 0| 5| 7| 7| 5| 7| 5| 5| 5| 5| 7| 4| 0| 5| 5| 1| 4| 5| 7| 5| 0| 5| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                   1      |             
      Olfactory Epithelium, Necrosis       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                           1                              |             
      Nephropathy                          | 1     1        1  1  1  1     1  1     1  1  1        1           1     1|             
      Renal Tubule, Necrosis               |                                                                2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 5| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 4| 7| 5|             
                             DAY ON TEST   | 3| 2| 3| 3| 5| 0| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 6| 4| 3| 6|             
                                           | 5| 0| 0| 5| 7| 9| 5| 5| 2| 7| 5| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 4| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   | X                                                                        |             
      Hematopoietic Cell Proliferation     |                                           3                    2         |             
      Infarct                              |                                                                         4|             
      Karyomegaly                          |                                                                      1   |             
      Mitotic Alteration                   |                                           3                              |             
      Necrosis                             |                                                                          |             
      Bile Duct, Cyst                      |                                                       X                  |             
      Centrilobular, Necrosis              |       2        2                                                        3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                 +                          +         |             
      Fat, Necrosis                        |                   2                                            2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                   2                                                      |             
      Hyperplasia, Squamous                |    2        1  2        1  1  1  1  4              1  3        2  2     3|             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                   2     2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
      Dysplasia                            |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1              1              1     1  1  2  1           1           1   |             
      Inflammation, Suppurative            |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hypertrophy                          | 1                                                     1                  |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 5| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 4| 7| 5|             
                             DAY ON TEST   | 3| 2| 3| 3| 5| 0| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 6| 4| 3| 6|             
                                           | 5| 0| 0| 5| 7| 9| 5| 5| 2| 7| 5| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 4| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          | 1                                                     1                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  M  M  +  +  M  M  +  +  +  M  M  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 1                 1           4  2  2        4           2  1            |             
      Pars Distalis, Inflammation, Chronic |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          2                                                               |             
      Follicle, Cyst                       |                                           X              X               |             
      Follicular Cell, Hyperplasia         | 1                    1                                   1           1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  M  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2        2        2           2     2                                   2|             
      Cyst                                 | X              X                                                         |             
      Germinal Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Hyperplasia            |          2                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Hyperplasia, Cystic                  |    2  2  3  1  1  3  2        2  3  2  4  2  3     2  4  3  2  2  2  3  2|             
      Inflammation, Suppurative            |       2                                                                  |             
      Arteriole, Hypertrophy               |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Megakaryocyte           |                2                                                         |             
      Hyperplasia, Neutrophil              |                                           2                    3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  M  +  +  +  +  M  M  M  M  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                       2  2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  M  M  M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M|             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |          4                                2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +|             
      Hyperplasia                          |                                           2                    2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 5| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 4| 7| 5|             
                             DAY ON TEST   | 3| 2| 3| 3| 5| 0| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 6| 4| 3| 6|             
                                           | 5| 0| 0| 5| 7| 9| 5| 5| 2| 7| 5| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 4| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                2        2                 4                    2     1   |             
      Hyperplasia, Lymphoid                | 4  2                                                                 1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  I|             
      Angiectasis                          |                                                          2               |             
      Atrophy                              |                2        2        2                                       |             
      Hyperplasia, Lymphoid                |                                        2                 2               |             
      Necrosis                             |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                4                                                         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       1  1        1           2        1     1        2              1   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       | 1        1     1              1           1  1              1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         4                                   2            |             
      Inflammation, Acute                  |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  2                                       |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 5| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 4| 7| 5|             
                             DAY ON TEST   | 3| 2| 3| 3| 5| 0| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 6| 4| 3| 6|             
                                           | 5| 0| 0| 5| 7| 9| 5| 5| 2| 7| 5| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 4| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Olfactory Epithelium, Necrosis       |       1                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |       1                             1                                    |             
      Nephropathy                          | 1        1                       1  1  1  2  1        1  1               |             
      Renal Tubule, Necrosis               |                                                                         3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 6| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 3| 3| 6| 5| 3| 3| 1| 3|                                            |            |
                                           | 7| 9| 5| 5| 4| 7| 5| 5| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    200 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  A  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +                                             |  56        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  M  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  M  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A  +  +  +  +  +  +  +  +                                             |  59        |
      Eosinophilic Focus                   |                X     X                                                   |      4     |
      Hematopoietic Cell Proliferation     |             3                                                            |      4  2.3|
      Infarct                              |                                                                          |      1  4.0|
      Karyomegaly                          |                                                                          |      1  1.0|
      Mitotic Alteration                   |                                                                          |      1  3.0|
      Necrosis                             |             2                                                            |      2  2.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Centrilobular, Necrosis              |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Necrosis                        |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  A  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +     +                                             |  58        |
      Hyperkeratosis                       |             3                                                            |      5  2.2|
      Hyperplasia, Squamous                | 1     3        2  2                                                      |     25  2.3|
      Inflammation, Suppurative            |                                                                          |      3  2.3|
      Ulcer                                |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Dysplasia                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  M  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |       1                                                                  |     15  1.1|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 6| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 3| 3| 6| 5| 3| 3| 1| 3|                                            |            |
                                           | 7| 9| 5| 5| 4| 7| 5| 5| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    200 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  A  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1     |
      Hypertrophy                          |                                                                          |      3  1.0|
      Capsule, Hyperplasia                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  A  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M  +  +  M  M  +  M                                             |  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  +  +  +  +  +  +  +                                             |  58        |
      Pars Distalis, Cyst                  |             X                                                            |      1     |
      Pars Distalis, Hyperplasia           |             1  1     2  1                                                |     21  1.9|
      Pars Distalis, Inflammation, Chronic |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation                         |                                                                          |      1  2.0|
      Follicle, Cyst                       |             X                                                            |      3     |
      Follicular Cell, Hyperplasia         |                   1                                                      |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  A  +  M  +  +  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  A  +  +  +  +  +  +  +  +                                             |  57        |
      Atrophy                              |             3                                                            |     13  2.2|
      Cyst                                 | X     X           X  X  X                                                |     13     |
      Germinal Epithelium, Hyperplasia     |                                                                          |      1  3.0|
      Interstitium, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  A  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      2  1.5|
      Hyperplasia, Cystic                  | 1     1  4  2  3  4  2  3  4                                             |     52  2.3|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Arteriole, Hypertrophy               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Megakaryocyte           |                                                                          |      1  2.0|
      Hyperplasia, Neutrophil              |                            2                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 6| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 3| 3| 6| 5| 3| 3| 1| 3|                                            |            |
                                           | 7| 9| 5| 5| 4| 7| 5| 5| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    200 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  +  M  +                                             |  46        |
      Hyperplasia                          |                      2                                                   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +                                             |  41        |
      Hyperplasia                          |       2              2                                                   |      5  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  A  +  M  +  +  +  +  +  +                                             |  51        |
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  A  +  +  M  +  +  +  M  +                                             |  41        |
      Hyperplasia                          |                   2  2                                                   |      5  2.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |             3              1                                             |     11  2.1|
      Hyperplasia, Lymphoid                |                      2                                                   |      5  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  A  +  +  +  +  +  +  +  +                                             |  51        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              |             3                                                            |      5  2.0|
      Hyperplasia, Lymphoid                |       2  2           2                                                   |      8  1.6|
      Necrosis                             |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  A  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  A  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               | 1     2  2        2                                                      |     19  1.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  A  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                            1                                             |      3  1.7|
      Mineralization                       |       1     1        1                                                   |     20  1.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 3| 7| 7| 6| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 2| 3| 3| 6| 5| 3| 3| 1| 3|                                            |            |
                                           | 7| 9| 5| 5| 4| 7| 5| 5| 9| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    200 PPM                                | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  A  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  A  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                         1                                                |      4  2.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  +  +  +  +  +  +                                             |  59        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      2  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  1.0|
      Olfactory Epithelium, Necrosis       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  A  +  +  +  +  +  +  +  +                                             |  58        |
      Metaplasia, Osseous                  |                                                                          |      3  1.0|
      Nephropathy                          |       1              1                                                   |     25  1.0|
      Renal Tubule, Necrosis               |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  M  +  +                                             |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 3| 5| 3| 3| 5| 1| 3| 5| 4| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 6| 3| 5| 2| 7|             
                                           | 8| 3| 6| 3| 3| 6| 4| 3| 6| 6| 3| 3| 3| 3| 3| 3| 8| 6| 3| 3| 3| 3| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  M  +  +  +  A|             
      Degeneration                         |                                                                          |             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  A  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                              X                           |             
      Clear Cell Focus                     |                      X        X                                          |             
      Cytomegaly                           |                                                                          |             
      Degeneration, Fatty                  |                         1        2                                       |             
      Eosinophilic Focus                   |                                           X                              |             
      Focal Cellular Change                |          1                                                               |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hemorrhage                           |                            3                                             |             
      Infarct                              |             4                                                            |             
      Karyomegaly                          |                               1                                          |             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |                                        X                                 |             
      Necrosis                             |                                                 3           2            |             
      Bile Duct, Degeneration              |                   3                                                      |             
      Bile Duct, Hyperplasia               |                   3                                                      |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                         +                       +      |             
      Fat, Necrosis                        | 2                                         2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Focal Cellular Change                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                             2            |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                             1            |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Hemosiderin            |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 3| 5| 3| 3| 5| 1| 3| 5| 4| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 6| 3| 5| 2| 7|             
                                           | 8| 3| 6| 3| 3| 6| 4| 3| 6| 6| 3| 3| 3| 3| 3| 3| 8| 6| 3| 3| 3| 3| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
      Dysplasia                            |                                                                      4   |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1              1  1     1  1  1  1     1           1  1  1  1  2  1  1|             
      Necrosis                             |                   2                                                      |             
      Arteriole, Inflammation, Chronic     | 2                                            2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          | 2  1              1           1  2  1  1  1  1     2  1  1     4         |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                   1     1        1                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  M  +  +  M  M  +  +  M|             
      Hyperplasia                          |                                  4                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Cyst                  |    X                                X                                    |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                      4           1                       1  4            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                        4     3                           |             
      Inflammation, Chronic Active         |    3        3     4     2           4  3                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 3| 5| 3| 3| 5| 1| 3| 5| 4| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 6| 3| 5| 2| 7|             
                                           | 8| 3| 6| 3| 3| 6| 4| 3| 6| 6| 3| 3| 3| 3| 3| 3| 8| 6| 3| 3| 3| 3| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            4                                             |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                      +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  M  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  M  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       2                                            2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  M  M  +  +  +  M  +  +  M  M  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                   1      |             
      Hematopoietic Cell Proliferation     |                   2        3        1     1                       3      |             
      Hyperplasia, Lymphoid                |                                                          2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  M  +|             
      Atrophy                              | 2                          1                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Pinna, Granuloma                     |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |       2              1                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2                    1  1           1        1     1        1     1   |             
      Thrombosis                           | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 5| 7| 4| 6| 6|             
                             DAY ON TEST   | 9| 3| 5| 3| 3| 5| 1| 3| 5| 4| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 6| 3| 5| 2| 7|             
                                           | 8| 3| 6| 3| 3| 6| 4| 3| 6| 6| 3| 3| 3| 3| 3| 3| 8| 6| 3| 3| 3| 3| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                          1                 1  2      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                      2   |             
      Inflammation, Suppurative            |                                                       1                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                      2   |             
      Olfactory Epithelium, Atrophy        |          1                    1                                      2   |             
      Olfactory Epithelium, Metaplasia     |          1                    1                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                   4      |             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Cystic                  |             1                                                            |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |    1  1  1  1        1        2  1  2  2  1  1     1  1        1     1   |             
      Arteriole, Inflammation, Chronic     | 2                                                                        |             
      Cortex, Cyst                         |                                  1  1                                    |             
      Renal Tubule, Mineralization         |                               1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 5| 7| 7| 5| 4|             
                             DAY ON TEST   | 1| 3| 9| 5| 3| 5| 3| 3| 3| 3| 2| 3| 5| 3| 7| 3| 5| 5| 3| 3| 4| 3| 3| 9| 5|             
                                           | 6| 7| 5| 6| 3| 6| 3| 3| 3| 3| 9| 3| 0| 3| 8| 3| 6| 6| 3| 3| 8| 3| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Degeneration                         |             1                                                            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |    1                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Peyer's Patch, Hyperplasia           |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |             X           X                                                |             
      Cytomegaly                           |                                                                          |             
      Degeneration, Fatty                  |                                           4                              |             
      Eosinophilic Focus                   | X           X                                         X                  |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   1      |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                                          |             
      Karyomegaly                          |                                  1                                1      |             
      Mitotic Alteration                   |                                                                   2      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             | 2                                                                        |             
      Bile Duct, Degeneration              |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Necrosis              |    4                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2                                       |             
      Focal Cellular Change                |    2                                                              1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                          1               |             
      Hyperplasia, Squamous                |                                           3           2                  |             
      Inflammation, Suppurative            |                                           2                              |             
      Ulcer                                |                               1                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 5| 7| 7| 5| 4|             
                             DAY ON TEST   | 1| 3| 9| 5| 3| 5| 3| 3| 3| 3| 2| 3| 5| 3| 7| 3| 5| 5| 3| 3| 4| 3| 3| 9| 5|             
                                           | 6| 7| 5| 6| 3| 6| 3| 3| 3| 3| 9| 3| 0| 3| 8| 3| 6| 6| 3| 3| 8| 3| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
      Dysplasia                            |                                                                          |             
      Inflammation                         |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1                 1  1  1  1  1  1  1  1  1  1        1  1  1  1  1  1   |             
      Necrosis                             |                                                                          |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2     3           2        4  1              2        2      |             
      Hypertrophy                          | 1  1                 2  2  2     2  1  1        2     1                  |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 1                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Cyst                  |                   X                                      X               |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                            1           1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                                  |             
      Ectasia                              |                               3                                   4      |             
      Inflammation, Chronic Active         | 1                                   4     1                    3  2  3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                       1                                   1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 5| 7| 7| 5| 4|             
                             DAY ON TEST   | 1| 3| 9| 5| 3| 5| 3| 3| 3| 3| 2| 3| 5| 3| 7| 3| 5| 5| 3| 3| 4| 3| 3| 9| 5|             
                                           | 6| 7| 5| 6| 3| 6| 3| 3| 3| 3| 9| 3| 0| 3| 8| 3| 6| 6| 3| 3| 8| 3| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                                        1                                 |             
      Hyperplasia, Neutrophil              |       4              2                                         3  2  4   |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  M  +  +  M  M  +  +  M  +  M  +  M  M  +  +  +  +  +  +  M|             
      Hyperplasia                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  M  M  +  M  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +|             
      Hyperplasia                          |       3                                                           2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                               1                                          |             
      Hyperplasia                          |       2                                                  3        4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  M  +  +  M  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 3                             2                             1     3  3   |             
      Hyperplasia, Lymphoid                |             1           3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  1                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               4                                          |             
      Pinna, Granuloma                     |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |       3              3                                         4     4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  1        1                    2  2     1     1           1        1  1|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 5| 7| 7| 5| 4|             
                             DAY ON TEST   | 1| 3| 9| 5| 3| 5| 3| 3| 3| 3| 2| 3| 5| 3| 7| 3| 5| 5| 3| 3| 4| 3| 3| 9| 5|             
                                           | 6| 7| 5| 6| 3| 6| 3| 3| 3| 3| 9| 3| 0| 3| 8| 3| 6| 6| 3| 3| 8| 3| 3| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             1                                                            |             
      Alveolar Epithelium, Hyperplasia     |                               2           1  2        1                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
      Inflammation, Suppurative            |       4                       1                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       2                                   2                              |             
      Olfactory Epithelium, Atrophy        |       4                                                                  |             
      Olfactory Epithelium, Metaplasia     |       1                                                                  |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |       1                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +              +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hydronephrosis                       |                                                                      1   |             
      Hyperplasia, Cystic                  |                                              1                           |             
      Inflammation, Suppurative            |                                                                      2   |             
      Nephropathy                          |       2     1  1  1  1  1  2  1  1  1  1  1  1        1  1  1  1  1      |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
      Cortex, Cyst                         |             X                                                            |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3|                                            |            |
                                           | 3| 1| 3| 3| 3| 6| 3| 3| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Degeneration                         |       4                                                                  |      2  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      4     |
      Cytomegaly                           |       3                                                                  |      1  3.0|
      Degeneration, Fatty                  |                1  1                                                      |      5  1.8|
      Eosinophilic Focus                   |                            X                                             |      5     |
      Focal Cellular Change                |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infarct                              |             4                                                            |      2  4.0|
      Karyomegaly                          |       3                                                                  |      4  1.5|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                            X                                             |      2     |
      Necrosis                             |       2     2                                                            |      5  2.2|
      Bile Duct, Degeneration              |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  3.0|
      Centrilobular, Necrosis              |                         2                                                |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  2.0|
      Focal Cellular Change                |       1                                                                  |      3  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Squamous                |                                                                          |      3  2.3|
      Inflammation, Suppurative            |          1                                                               |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3|                                            |            |
                                           | 3| 1| 3| 3| 3| 6| 3| 3| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Erosion                              |                         1                                                |      2  1.0|
      Inflammation, Suppurative            |          1                                                               |      1  1.0|
      Pigmentation, Hemosiderin            |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   3        |
      Dysplasia                            |    2                                                                     |      2  3.0|
      Inflammation                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 1  1  2  1  1     1  1                                                   |     40  1.1|
      Necrosis                             |                                                                          |      1  2.0|
      Arteriole, Inflammation, Chronic     |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      7  2.3|
      Hypertrophy                          | 1              1  2  1     1                                             |     28  1.4|
      Capsule, Hyperplasia                 |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |       1                                                                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia                          |       1  1                                                               |      6  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  M  +                                             |  46        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  I  +  M  +  +  +                                             |  56        |
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia           | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Follicular Cell, Hyperplasia         | 2                                                                        |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3|                                            |            |
                                           | 3| 1| 3| 3| 3| 6| 3| 3| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |    3                                                                     |      2  3.0|
      Ectasia                              |                                                                          |      4  3.5|
      Inflammation, Chronic Active         |                      2     4                                             |     14  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  M  +  +  +  +  +                                             |  54        |
      Inflammation, Suppurative            |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  4.0|
      Fibrosis                             |                   1                                                      |      2  1.0|
      Hyperplasia, Neutrophil              |                                                                          |      5  3.0|
      Thrombosis                           |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  +  +  M  +                                             |  41        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  M  M  M  M  +  +  +                                             |  43        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +                                             |  56        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |             2                                                            |      2  1.5|
      Hyperplasia                          |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  I  +  +                                             |  47        |
      Hyperplasia                          |             3                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |       3     1                                                            |     12  2.2|
      Hyperplasia, Lymphoid                |                            2                                             |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  I  +  +  +  +  +  +                                             |  53        |
      Atrophy                              |                                                                          |      4  1.3|
      Hyperplasia, Lymphoid                |             4                                                            |      1  4.0|
      Necrosis                             |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3|                                            |            |
                                           | 3| 1| 3| 3| 3| 6| 3| 3| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Pinna, Granuloma                     |    3                                                                     |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      6  2.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |    1  1           2  1     1                                             |     23  1.2|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      5  1.4|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 2                                                                        |      4  2.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      4  2.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      3  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                       +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Hydronephrosis                       | 1     1                                                                  |      3  1.0|
      Hyperplasia, Cystic                  |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 4| 7| 7| 4| 7|                                            |            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 5| 3| 3| 3| 3|                                            |            |
                                           | 3| 1| 3| 3| 3| 6| 3| 3| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nephropathy                          | 1     2  1  1  1  1  1     1                                             |     41  1.1|
      Arteriole, Inflammation, Chronic     |                                                                          |      1  2.0|
      Cortex, Cyst                         |       1  1                                                               |      5  1.0|
      Renal Tubule, Mineralization         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 4| 7| 4| 6| 7| 7| 4| 4| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 0| 3| 2| 3| 1| 5| 3| 3| 3| 2| 7| 3| 3| 5| 5| 6| 3| 3|             
                                           | 4| 4| 6| 4| 4| 4| 4| 2| 4| 3| 4| 4| 6| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 PPM                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Degeneration                         |                                                                   2      |             
      Inflammation, Suppurative            |                2                                                        2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |          3                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |          X                                                               |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |       2                             2  2        2           2  2        2|             
      Eosinophilic Focus                   |                   X                                            X         |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                                          |             
      Karyomegaly                          |                                                                          |             
      Mitotic Alteration                   |                                                                      3   |             
      Mixed Cell Focus                     |                   X                                X  X                  |             
      Necrosis                             |             1                                      1                     |             
      Bile Duct, Cyst                      |          1                                                               |             
      Centrilobular, Necrosis              |                      2                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         1|             
      Focal Cellular Change                |                                                 1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                         2|             
      Inflammation, Suppurative            | 1                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                       4  2               |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                    1                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 4| 7| 4| 6| 7| 7| 4| 4| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 0| 3| 2| 3| 1| 5| 3| 3| 3| 2| 7| 3| 3| 5| 5| 6| 3| 3|             
                                           | 4| 4| 6| 4| 4| 4| 4| 2| 4| 3| 4| 4| 6| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 PPM                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1     1  2  1  1  1  1  1  1        1  1  1     1  1  1  1     1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   X                                                      |             
      Cyst                                 |                                              X                           |             
      Hyperplasia                          | 2  4                                                  2  1               |             
      Hypertrophy                          |    1  1  1     1  1              2     1     2        2     1  1  1  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                            1        1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                          X               |             
      Pars Distalis, Hyperplasia           | 1                                                        2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         | 1           1                                            1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                4  3                                3              2      |             
      Inflammation, Chronic Active         |          1  2  2  2  3  4                                4               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2                              |             
      Mineralization                       |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Megakaryocyte           |                                  2                                       |             
      Hyperplasia, Neutrophil              |             2              2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 4| 7| 4| 6| 7| 7| 4| 4| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 0| 3| 2| 3| 1| 5| 3| 3| 3| 2| 7| 3| 3| 5| 5| 6| 3| 3|             
                                           | 4| 4| 6| 4| 4| 4| 4| 2| 4| 3| 4| 4| 6| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 PPM                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Iliac, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  M  M  M  +  +  +  +  M  M  +  M  +  +  M  M  +  +  +  +  M  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3                                                   |             
      Hyperplasia                          |             2                                                        3  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  M  +  +  M  +  +  +  +  +  M  +  +  I  +  +  M  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2  2        2     2     2                                2  2   |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    2                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |             4              4                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1  1     1  1              1        2  1                    1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           2                       1      |             
      Alveolar Epithelium, Hyperplasia     | 1                                            2                          1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                      1   |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 4| 7| 4| 6| 7| 7| 4| 4| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 0| 3| 2| 3| 1| 5| 3| 3| 3| 2| 7| 3| 3| 5| 5| 6| 3| 3|             
                                           | 4| 4| 6| 4| 4| 4| 4| 2| 4| 3| 4| 4| 6| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 PPM                                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                +              +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Cystic                  |                   1                                                      |             
      Inflammation, Suppurative            |                      2                                                   |             
      Metaplasia, Osseous                  |                1                                                         |             
      Nephropathy                          | 1  1     1  1  3  2     1  1  1  3     2     1        1  1        3  1  2|             
      Cortex, Cyst                         |                                              X                          X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            3                                             |             
      Hemorrhage                           |                      2                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                      2                                                   |             
      Pigmentation, Melanin                |                                                                          |             
      Ulcer                                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 8| 3| 4| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 0| 3| 9| 5| 3| 3| 3| 3| 5| 5|             
                                           | 4| 3| 4| 8| 4| 4| 4| 4| 6| 6| 4| 4| 4| 4| 6| 0| 4| 5| 6| 4| 4| 4| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 PPM                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration                         |                                                                          |             
      Inflammation, Suppurative            |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                                               |             
      Basophilic Focus                     |                   X                                                      |             
      Clear Cell Focus                     |                                                          X               |             
      Degeneration, Fatty                  |                            1                                1            |             
      Eosinophilic Focus                   |                                  X  X                       X            |             
      Hematopoietic Cell Proliferation     |                                              2     1                     |             
      Hemorrhage                           |             1                                                            |             
      Infarct                              |                                                                   4      |             
      Karyomegaly                          |    1                                         1                           |             
      Mitotic Alteration                   |                                              1                           |             
      Mixed Cell Focus                     |                   X              X                                       |             
      Necrosis                             |                                                                          |             
      Bile Duct, Cyst                      |                               X                                   4      |             
      Centrilobular, Necrosis              |    1                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +  +                                      +      |             
      Angiectasis                          |                                                                   4      |             
      Inflammation, Chronic                |                         3                                                |             
      Fat, Necrosis                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Focal Cellular Change                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                           4                    4        4|             
      Inflammation, Suppurative            |                                                                3         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 8| 3| 4| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 0| 3| 9| 5| 3| 3| 3| 3| 5| 5|             
                                           | 4| 3| 4| 8| 4| 4| 4| 4| 6| 6| 4| 4| 4| 4| 6| 0| 4| 5| 6| 4| 4| 4| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 PPM                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1     1  1     1        1  1  1        1  1  1     1  1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |             1              1     1           2                 2         |             
      Hypertrophy                          | 1  1  1     2  2  1           1  2  1  3        2  1  1     2     2  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2           1               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  I  M  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia           |                                                 1                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                             X            |             
      Follicular Cell, Hyperplasia         | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   3           4                 3           4  3         |             
      Inflammation, Chronic Active         | 2                       3     2  3  2                    3     1         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              1                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Hyperplasia, Neutrophil              |                         2                    2     3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 8| 3| 4| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 0| 3| 9| 5| 3| 3| 3| 3| 5| 5|             
                                           | 4| 3| 4| 8| 4| 4| 4| 4| 6| 6| 4| 4| 4| 4| 6| 0| 4| 5| 6| 4| 4| 4| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 PPM                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                              +                           |             
      Iliac, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  M  M  M  +|             
      Hyperplasia                          |    2                                   2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  M  +  M  +  +  +  M  +  M  +|             
      Hyperplasia                          |                                        2        2        1               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Congestion                           |                                                       1                  |             
      Hyperplasia                          |                      2        2  2     2        3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +|             
      Hyperplasia                          |    2                                   2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          1              2                    1     2           1         |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Epithelial Cell, Hyperplasia         |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                         2                          4           4        2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       2        2                    1     1     1     1  1     1  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      1   |             
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                          1               |             
      Olfactory Epithelium, Atrophy        |                                                          1               |             
      Olfactory Epithelium, Metaplasia     |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 8| 3| 4| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 0| 3| 9| 5| 3| 3| 3| 3| 5| 5|             
                                           | 4| 3| 4| 8| 4| 4| 4| 4| 6| 6| 4| 4| 4| 4| 6| 0| 4| 5| 6| 4| 4| 4| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    50 PPM                                 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                2              1                    1                     |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Suppurative            |                                                    1                     |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1  2  1     1  1  2  1  1  1  1  2  2  1  1     2        2  1  2  2      |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Dilatation                           |                         4                                                |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                    4                     |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Melanin                |                                        2                                 |             
      Ulcer                                |                                                    3                     |             
      Transitional Epithelium, Hyperplasia |       2                                1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 6| 7| 7| 6| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 7| 5| 1| 6| 3| 3| 5| 3| 9| 9|                                            |            |
                                           | 1| 6| 1| 4| 4| 4| 8| 4| 5| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    50 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +                                             |  56        |
      Cyst                                 |                                                                          |      1     |
      Degeneration                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +                                             |  58        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      2     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Fatty                  |                                                                          |      9  1.8|
      Eosinophilic Focus                   |                                                                          |      5     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infarct                              |          3                                                               |      2  3.5|
      Karyomegaly                          | 2                                                                        |      3  1.3|
      Mitotic Alteration                   | 4                                                                        |      3  2.7|
      Mixed Cell Focus                     |                X                                                         |      6     |
      Necrosis                             | 1              1                                                         |      4  1.0|
      Bile Duct, Cyst                      |                                                                          |      3  2.5|
      Centrilobular, Necrosis              |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Angiectasis                          |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  1.0|
      Focal Cellular Change                |                   1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 6| 7| 7| 6| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 7| 5| 1| 6| 3| 3| 5| 3| 9| 9|                                            |            |
                                           | 1| 6| 1| 4| 4| 4| 8| 4| 5| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    50 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                                                                          |      5  3.6|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 1     1  1  1  1  1  1  1  1                                             |     42  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |    1           4                                                         |     11  1.9|
      Hypertrophy                          |          2  1  2  1  2                                                   |     36  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                1     1                                                   |      7  1.1|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                      1                                                   |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |       3  2              3                                                |     12  3.1|
      Inflammation, Chronic Active         |                2  2                                                      |     16  2.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  M  +  +  +                                             |  53        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 6| 7| 7| 6| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 7| 5| 1| 6| 3| 3| 5| 3| 9| 9|                                            |            |
                                           | 1| 6| 1| 4| 4| 4| 8| 4| 5| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    50 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                      2                                                   |      1  2.0|
      Inflammation, Suppurative            |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Megakaryocyte           |                                                                          |      1  2.0|
      Hyperplasia, Neutrophil              |                         3  3                                             |      7  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   2        |
      Iliac, Hyperplasia                   |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  +                                             |  44        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  M  +  +  +  M  +                                             |  39        |
      Hyperplasia                          |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      2  2.0|
      Hyperplasia                          |             1        2                                                   |     10  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  M  M  +  +  +  +                                             |  45        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     | 2                       1  2                                             |     15  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +                                             |  54        |
      Atrophy                              |                   3                                                      |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                         4  2                                             |      8  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 6| 7| 7| 6| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 7| 5| 1| 6| 3| 3| 5| 3| 9| 9|                                            |            |
                                           | 1| 6| 1| 4| 4| 4| 8| 4| 5| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    50 PPM                                 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       | 1           1  1  1  1  1  2                                             |     26  1.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |          2                                                               |      4  1.5|
      Alveolar Epithelium, Hyperplasia     |                1                                                         |      5  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                1                                                         |      2  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  1.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydronephrosis                       |                         2  1                                             |      5  1.4|
      Hyperplasia, Cystic                  |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                            2                                             |      3  1.7|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          | 1           2  2  2  1                                                   |     41  1.5|
      Cortex, Cyst                         |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Dilatation                           |                                                                          |      2  3.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                            4                                             |      2  3.0|
      Pigmentation, Melanin                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 4| 6| 6| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3| 3| 5|             
                                           | 2| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4| 0| 6| 6| 8| 5| 4| 4| 4| 4| 4| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |          3                                                               |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                   4      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Basophilic Focus                     |       X                                                              X   |             
      Clear Cell Focus                     |                                                                   X      |             
      Degeneration, Fatty                  |                            1  2  1        2                 1  1  1     2|             
      Eosinophilic Focus                   |                   X                                X                     |             
      Hematopoietic Cell Proliferation     |    1                                                                     |             
      Infarct                              |             4                          4                                 |             
      Karyomegaly                          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Fat, Necrosis                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          2               |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |    1                                                  3                  |             
      Hyperplasia, Squamous                |          2        2                                         2  3     4   |             
      Inflammation, Suppurative            |          3                                                  2  2     2   |             
      Ulcer                                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 4| 6| 6| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3| 3| 5|             
                                           | 2| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4| 0| 6| 6| 8| 5| 4| 4| 4| 4| 4| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1     1  1  1  1        1  1  1  1        1  1     1  1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  X                                       |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |       2              2  1                                            2  2|             
      Hypertrophy                          |                   1        1  2  1        1           1        1         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1                 1           1     1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                          X               |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                  4                                       |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       4        4                                         4               |             
      Inflammation, Chronic Active         |    1                                   4                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  M  +  M  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 1                        |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |    4                                                                 2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                                 |             
      Pancreatic, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 4| 6| 6| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3| 3| 5|             
                                           | 2| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4| 0| 6| 6| 8| 5| 4| 4| 4| 4| 4| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia                   |                                        4                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  M  +  M  +  +  +  +  +  M  +  M  M  M  M  +  +  +  M  +  +  M  +|             
      Hyperplasia                          |                                                                4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                 3                 3      |             
      Hematopoietic Cell Proliferation     |    1                                                                     |             
      Hyperplasia                          |                   2                                         2  4  2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | A  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  M  +  M  M  +  I  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2     1                             2                          2      |             
      Hyperplasia, Lymphoid                |                                                       2        4         |             
                                            __________________________________________________________________________|             
   Thymus                                  | A  I  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +|             
      Atrophy                              |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |    4        4                                                        4   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             1           2                 1        2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           1                              |             
      Alveolar Epithelium, Hyperplasia     |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      1           1                                       |             
      Olfactory Epithelium, Atrophy        |                                                             1            |             
      Olfactory Epithelium, Metaplasia     |                                                             1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 4| 6| 6| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 5| 5| 5| 5| 6| 3| 3| 3| 3| 3| 3| 5|             
                                           | 2| 4| 4| 4| 6| 4| 4| 4| 6| 6| 4| 4| 4| 0| 6| 6| 8| 5| 4| 4| 4| 4| 4| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |    2                                                                     |             
      Inflammation, Suppurative            |    1                                                                     |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |    1  1  3     1  1  2  1     1  1  2        1  1     1  1  1  1  2  1  1|             
      Cortex, Cyst                         |                      2              1                                    |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             3                                                            |             
      Inflammation, Chronic                |    4                                                                     |             
      Ulcer                                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 4| 7| 6| 5| 7| 6| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 3| 1| 5| 3| 3| 6| 3| 5| 5| 3| 3| 3| 3| 5| 9| 2| 3| 3| 6| 3| 4| 7|             
                                           | 4| 4| 7| 4| 6| 6| 4| 6| 7| 4| 8| 6| 7| 4| 4| 4| 6| 2| 0| 4| 4| 4| 4| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Suppurative            |                                              1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                X         |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |                                  2                                2      |             
      Eosinophilic Focus                   |                                        X              X                  |             
      Hematopoietic Cell Proliferation     |                      1                                               1   |             
      Infarct                              |                                                                          |             
      Karyomegaly                          |                      2                                                   |             
      Mixed Cell Focus                     |          X                                   X                           |             
      Necrosis                             |                                                             1            |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                           +   |             
      Fat, Necrosis                        |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   1                                                  4   |             
      Inflammation, Chronic                |                                                                      4   |             
      Duct, Ectasia                        |                                                                      3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |    2                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Hyperplasia                          |    1                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 4| 7| 6| 5| 7| 6| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 3| 1| 5| 3| 3| 6| 3| 5| 5| 3| 3| 3| 3| 5| 9| 2| 3| 3| 6| 3| 4| 7|             
                                           | 4| 4| 7| 4| 6| 6| 4| 6| 7| 4| 8| 6| 7| 4| 4| 4| 6| 2| 0| 4| 4| 4| 4| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1     1  3  1  1  1        1  1  1     1  1  1  1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |                                                                      X   |             
      Hyperplasia                          |                      3           1                       2               |             
      Hypertrophy                          | 1  1     1     1  1        2  1           1  3  1           1  1  1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                  1     1            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                              X                    X      |             
      Follicular Cell, Hyperplasia         |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic Active         |                                        3  4     1     4                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  M  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                         1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                         3                          1        2  4     2  4|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                      +   |             
      Pancreatic, Hyperplasia              |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 4| 7| 6| 5| 7| 6| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 3| 1| 5| 3| 3| 6| 3| 5| 5| 3| 3| 3| 3| 5| 9| 2| 3| 3| 6| 3| 4| 7|             
                                           | 4| 4| 7| 4| 6| 6| 4| 6| 7| 4| 8| 6| 7| 4| 4| 4| 6| 2| 0| 4| 4| 4| 4| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  M  +  M  +  M  +  +  M  +  M  +  M  I  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  M  +  +  M  +  M  +  +  M  +  M  +  +  +  +  M  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2        4                                            2               |             
      Hematopoietic Cell Proliferation     |                                                          2              3|             
      Hyperplasia                          | 3                                                           2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  M  +  +  M  +  A  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                      4   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          1  2        2  2                          1  2     2  2     3  2|             
      Hyperplasia, Lymphoid                | 1                                            1                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +|             
      Atrophy                              |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                         4                          2        2  4     2  4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       1  1        1           1        2  1     1  1  1                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                           1        2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                   1      |             
      Olfactory Epithelium, Metaplasia     |                                                                   1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 4| 7| 6| 5| 7| 6| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 2| 3| 1| 5| 3| 3| 6| 3| 5| 5| 3| 3| 3| 3| 5| 9| 2| 3| 3| 6| 3| 4| 7|             
                                           | 4| 4| 7| 4| 6| 6| 4| 6| 7| 4| 8| 6| 7| 4| 4| 4| 6| 2| 0| 4| 4| 4| 4| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                2                 2                             2         |             
      Inflammation, Suppurative            |                                                                         2|             
      Metaplasia, Osseous                  |                                                          1               |             
      Nephropathy                          | 1  1     1  1        4     1           1  1  1  1  1     1  1     1      |             
      Cortex, Cyst                         |          1                                                               |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                3         |             
      Inflammation, Chronic                |                                                                         3|             
      Ulcer                                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 5| 7| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 9| 3| 5| 3| 3| 0|                                            |            |
                                           | 6| 4| 4| 4| 5| 4| 6| 4| 4| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    100 PPM                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Degeneration                         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Peyer's Patch, Hyperplasia           |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |       X           X                                                      |      5     |
      Clear Cell Focus                     |                         X                                                |      2     |
      Degeneration, Fatty                  |                3  1                                                      |     12  1.6|
      Eosinophilic Focus                   |             X                                                            |      5     |
      Hematopoietic Cell Proliferation     |             1                                                            |      4  1.0|
      Infarct                              |                                                                          |      2  4.0|
      Karyomegaly                          |                            2                                             |      2  2.0|
      Mixed Cell Focus                     |    X                                                                     |      3     |
      Necrosis                             |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                            2                                             |      1  2.0|
      Kupffer Cell, Pigmentation           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      3  2.3|
      Inflammation, Chronic                |                         1                                                |      2  2.5|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperkeratosis                       |                            1                                             |      3  1.7|
      Hyperplasia, Squamous                |                                                                          |      6  2.5|
      Inflammation, Suppurative            |                                                                          |      4  2.3|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Degeneration                         |                1                                                         |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 5| 7| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 9| 3| 5| 3| 3| 0|                                            |            |
                                           | 6| 4| 4| 4| 5| 4| 6| 4| 4| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    100 PPM                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cardiomyopathy                       |    1  1  1  1  1     1  1  2                                             |     46  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |    1           2  2  2     2                                             |     13  1.8|
      Hypertrophy                          |       1  1              1                                                |     23  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |       1  1                                                               |      9  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +                                             |  56        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Follicle, Cyst                       |                                                                          |      2     |
      Follicular Cell, Hyperplasia         |       2                                                                  |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Granuloma Sperm                      |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Ectasia                              |    4                                                                     |      4  4.0|
      Inflammation, Chronic Active         |             3     2     4                                                |      9  2.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 5| 7| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 9| 3| 5| 3| 3| 0|                                            |            |
                                           | 6| 4| 4| 4| 5| 4| 6| 4| 4| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    100 PPM                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  1.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Neutrophil              |             4                                                            |      9  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Pancreatic, Hyperplasia              |                                                                          |      1  3.0|
      Renal, Hyperplasia                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  +  M  +  +  +  +  M                                             |  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  M  +  M  M  M  +                                             |  36        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Congestion                           |                                                                          |      5  2.8|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.0|
      Hyperplasia                          |       2  1                                                               |      8  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  M  +  +  +  +  +  +                                             |  44        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hematopoietic Cell Proliferation     |             2              2                                             |     16  1.9|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +                                             |  48        |
      Atrophy                              |                            3                                             |      1  3.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |             4                                                            |     10  3.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 5| 7| 4| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 3| 9| 3| 5| 3| 3| 0|                                            |            |
                                           | 6| 4| 4| 4| 5| 4| 6| 4| 4| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      A     |
    100 PPM                                | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |       1              1  1                                                |     16  1.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Suppurative            |                         1                                                |      3  1.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      2  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hydronephrosis                       |                                                                          |      4  2.0|
      Inflammation, Suppurative            |             3                                                            |      3  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          |    1  1  2     2     1  1                                                |     39  1.3|
      Cortex, Cyst                         |                                                                          |      3  1.3|
      Renal Tubule, Hyperplasia            |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      2  3.0|
      Inflammation, Chronic                |             4                                                            |      3  3.7|
      Ulcer                                |             4                                                            |      1  4.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 4| 6| 4| 5| 4| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 5| 3| 3| 5| 4| 5| 3| 5| 3| 3| 3| 2| 5| 5| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 5| 3| 3| 6| 3| 3| 6| 3| 6| 2| 6| 3| 3| 3| 7| 6| 6| 3| 6| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1  1                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                  X                          X            |             
      Degeneration, Fatty                  |          2                                                        1  1   |             
      Eosinophilic Focus                   |                                                                         X|             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Karyomegaly                          |       1                                                                 1|             
      Mixed Cell Focus                     |                                  X                                       |             
      Necrosis                             |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                     1                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                   1      |             
      Hyperplasia, Squamous                |          2     2                 2              1        1     1         |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                            1     2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
      Erosion                              |                                           3                              |             
      Hyperplasia                          |    2                                                                     |             
      Pigmentation, Hemosiderin            |                                           3                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 4| 6| 4| 5| 4| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 5| 3| 3| 5| 4| 5| 3| 5| 3| 3| 3| 2| 5| 5| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 5| 3| 3| 6| 3| 3| 6| 3| 6| 2| 6| 3| 3| 3| 7| 6| 6| 3| 6| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Cardiomyopathy                       | 1  1  1     1  1     1     1        1  1  1        1     1  1  1  1     1|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                        X                                 |             
      Hyperplasia                          |    1              1           2                 2        2        4  2   |             
      Hypertrophy                          | 1  2  1  1  2     2        1           1  1     1  1     1     1  1  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                4                                3                        |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic Active         | 2  2        1        3  1                       1              4  1      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Suppurative            |                            1                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 4| 6| 4| 5| 4| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 5| 3| 3| 5| 4| 5| 3| 5| 3| 3| 3| 2| 5| 5| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 5| 3| 3| 6| 3| 3| 6| 3| 6| 2| 6| 3| 3| 3| 7| 6| 6| 3| 6| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |                      4     3           3                 2     2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  M  +  M  +  M  +  +  +  I  +  M  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           2                              |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  I  +  +  +  M  +  +  +  +  M  M  +  +  M  +  +  +  M  M  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |             2        2     2        2                    2               |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Hyperplasia, Mononuclear Cell        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                                             |             
      Epithelial Cell, Hyperplasia         |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |             4        4                 3                 3               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2     1              2     1           1  1        1     2     2     1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               2                 2                        |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 7| 4| 6| 4| 5| 4| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 5| 3| 3| 5| 4| 5| 3| 5| 3| 3| 3| 2| 5| 5| 3| 5| 3| 3| 3| 3| 3| 3|             
                                           | 5| 3| 3| 6| 3| 3| 6| 3| 6| 2| 6| 3| 3| 3| 7| 6| 6| 3| 6| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |    1                                               2                     |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Suppurative            |                            4                                             |             
      Nephropathy                          |    1  1     1  1                 1  2  1           1     1  1  1  1  1  1|             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3                                                                        |             
      Inflammation, Chronic                |                            4                                             |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                            4                                             |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 4| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|             
      Inflammation, Suppurative            |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                            2                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                  X                                       |             
      Degeneration, Fatty                  |    1                                                                     |             
      Eosinophilic Focus                   | X           X                                                  X         |             
      Focal Cellular Change                |                                                                   1      |             
      Hematopoietic Cell Proliferation     |                                              1                           |             
      Infarct                              |                      4                                                   |             
      Karyomegaly                          |             1                                                            |             
      Mixed Cell Focus                     |                                        X  X                              |             
      Necrosis                             |                                                             3            |             
      Bile Duct, Cyst                      |             X                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                    1                     |             
      Hyperplasia, Squamous                |                         1                    4  2              4  1      |             
      Inflammation, Suppurative            |                                              2                           |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |          2                                                               |             
      Ectopic Tissue                       |          X                                                               |             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                  2                                       |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
      Inflammation                         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 4| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cardiomyopathy                       | 1     1     1  1     1        1  2     1  1  1     1  1  1  1  1  1  1  1|             
      Necrosis                             |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia                          |          1                    2                                          |             
      Hypertrophy                          |       3        3  1  1     1  1  1        1     1  1  3  1     2  1     1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1        1           4                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  M  +  +  +  M  M  I  +  +  M  M  M  +  M  M  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                 X  X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                              1                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic Active         |          4     4                 2  1  2     3                 2  1  2  3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Inflammation, Suppurative            |                                              1                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              3                 2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 4| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |          3                                   4                 2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  M  M  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia                          |       1                    2                       1                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                                                        |             
      Hematopoietic Cell Proliferation     |          2           3                       3              3  2         |             
      Hyperplasia, Lymphoid                |             2              2     2     2  2                       2      |             
      Hyperplasia, Mononuclear Cell        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                         X                                                |             
      Inflammation, Suppurative            |                      4                                                   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |          2              4        3           4                 4         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2                          1  1  2              1     1           1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                3         |             
      Inflammation, Granulomatous          |          2                                                               |             
      Alveolar Epithelium, Hyperplasia     |                                              1                           |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  1                                1      |             
      Olfactory Epithelium, Atrophy        |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 4| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                    1                     |             
      Respiratory Epithelium, Hyperplasia  |                                              1                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                  1           1                    1     1|             
      Hyperplasia, Cystic                  |                                        2                 2               |             
      Inflammation, Suppurative            |                                              1                           |             
      Nephropathy                          | 1  1  1  1  1  1  1     1  1  1  1     1  1  1     1  1  1        1  1  1|             
      Cortex, Cyst                         |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                              4                           |             
      Ulcer                                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                  1           3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    200 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Inflammation, Suppurative            |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |    X                                                                     |      1     |
      Clear Cell Focus                     |                                                                          |      3     |
      Degeneration, Fatty                  |                                                                          |      4  1.3|
      Eosinophilic Focus                   |                                                                          |      4     |
      Focal Cellular Change                |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                         2                                                |      2  1.5|
      Infarct                              |                                                                          |      1  4.0|
      Karyomegaly                          |                                                                          |      3  1.0|
      Mixed Cell Focus                     |                                                                          |      3     |
      Necrosis                             |                                                                          |      1  3.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +        +                                                   |   3        |
      Fat, Necrosis                        |             3        3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Focal Cellular Change                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      2  1.0|
      Hyperplasia, Squamous                |    2  2        1           2                                             |     15  1.9|
      Inflammation, Suppurative            |       2                                                                  |      2  2.0|
      Ulcer                                |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration                         |                                                                          |      1  2.0|
      Ectopic Tissue                       |                                                                          |      1     |
      Erosion                              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    200 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      2  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  M  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  1  1                                             |     44  1.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hyperplasia                          |          4  2     1                                                      |     12  2.0|
      Hypertrophy                          | 1     1     2  1     2     1                                             |     37  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |       1                                                                  |      4  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  +  +  M  +  M  M                                             |  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Cyst                  |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Granuloma Sperm                      |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |       3                                                                  |      1  3.0|
      Ectasia                              |    4                       4                                             |      2  4.0|
      Inflammation, Chronic Active         |                3           3                                             |     20  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    200 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | M  +  +  +  +  +  +  +  +  +                                             |  54        |
      Inflammation, Suppurative            |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia, Neutrophil              |                   3     3  2                                             |     11  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +                                             |  44        |
      Hyperplasia                          |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +                                             |  58        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | I  +  +  +  +  +  M  M  M  I                                             |  40        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                   2     3  1                                             |     13  2.2|
      Hyperplasia, Lymphoid                |          2                                                               |      8  2.0|
      Hyperplasia, Mononuclear Cell        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +                                             |  57        |
      Atrophy                              |                                                                          |      1  3.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Suppurative            |                         4                                                |      2  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                   4                                                      |     10  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05133-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:07:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 9| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    200 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |             1        1                                                   |     20  1.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                            2                                             |      4  1.8|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydronephrosis                       |                                                                          |      6  1.2|
      Hyperplasia, Cystic                  |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Nephropathy                          | 1  1  1  1  1  1     1  1  1                                             |     43  1.0|
      Cortex, Cyst                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                   4                                                      |      3  3.3|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
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