National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2922

TDMS Study 05133-04 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95       
EXPERIMENT: 05133 TEST: 04                                                                                     TIME: 07:11:30       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 000242       
PATHOLOGIST: R. MILLER                       HAILEY, JAMES R.                                                  CAS: 75-05-8         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95      
EXPERIMENT: 05133 TEST: 04                                                                                     TIME: 07:11:30      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 000242      
PATHOLOGIST: R. MILLER                       HAILEY, JAMES R.                                                  CAS: 75-05-8        

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 10   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      437   457   546   548   563   581   595   595   598   623                 |
 |      637   650   675   678   698   714   716   729                             |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 10   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      426   434   571   583   595   595   602   623   636   648                 |
 |      658   664   664   674   692   700   711   714                             |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 10   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      342   537   567   573   595   607   616   636   636   644                 |
 |      650   658   658   664   665   692   720   727                             |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 7      CENSORED DEATHS 10   TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      532   554   643   665   692   701   727                                   |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456   456   456                 |
 |                                                                                |
 ==================================================================================

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  96.3  96.3  82.3  76.3  64.2      |
 |           |                                                                    |
 |           |                                                                    |
 |50 PPM     |   100.0 100.0 100.0 100.0 100.0  96.7  96.7  86.6  74.5  64.4      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0 100.0  98.3  98.3  98.3  96.3  90.3  70.2  64.2      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  96.0  92.0  86.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      50 PPM       100 PPM      200 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       64.2%        64.4%        64.2%        86.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.013N     P=1.000N     P=1.000N     P=0.017N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       613.3        621.7        621.5        644.9    |
 |NATURAL DEATHS (C)      |       (19.8)       (19.4)       (20.2)       (28.3)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       650.9        653.4        653.4        676.6    |
 |(STANDARD ERROR)        |       (14.5)       (14.3)       (14.4)       (13.7)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 11   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      426   426   517   569   581   622   623   635   641   658                 |
 |      664   678   681   681   694   699   700   706   706   710                 |
 |      720                                                                       |
 |  CENSORED DEATHS                                                               |
 |      5     457   457   457   457   457   457   457   457   457                 |
 |      457                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 10   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      369   435   548   579   595   602   621   622   639   646                 |
 |      664   664   665   686   687   711   717                                   |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 10   TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      552   570   583   635   643   650   663   664   665   668                 |
 |      670   670   671   700   704   706   708   712   719   727                 |
 |      734                                                                       |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 18     CENSORED DEATHS 10   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      127   294   329   444   472   491   509   510   510   566                 |
 |      630   644   650   664   664   678   719   720                             |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  96.6  94.6  90.4  78.1  57.6      |
 |           |                                                                    |
 |           |                                                                    |
 |50 PPM     |   100.0 100.0 100.0 100.0  98.3  96.7  96.7  88.6  74.5  66.5      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  94.0  82.0  58.0      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0  98.3  98.3  95.0  95.0  91.3  83.2  81.2  71.0  64.9      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      50 PPM       100 PPM      200 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       57.6%        66.5%        58.0%        64.9%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.905N     P=0.554N     P=0.918N     P=0.822N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       635.1        614.7        667.3        534.5    |
 |NATURAL DEATHS (C)      |       (19.0)       (22.5)       (10.9)       (37.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       641.5        654.6        665.0        628.5    |
 |(STANDARD ERROR)        |       (18.0)       (14.7)       (13.3)       (18.8)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            ACETONITRILE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        50 PPM           = 2
                                                        100 PPM          = 3
                                                        200 PPM          = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                     3            2 1              4
      |                                                       3            221   1           3
      |                                                                                     4   4
      |                                                                     2    1           31 432          4
   95 +                                                                                           2 2
      |                                                                                       11 33          4   4
      |                                                                                        1 13 2 2          4   4
      |
P  90 +                                                                                          1 1  3 3            4 4
E     |                                                                                            1  1233
R     |                                                                                                                4  4
C     |                                                                                                2 32 3             4 4
E  85 +                                                                                                   2 2
N     |                                                                                               11
T     |                                                                                                1  1 232
      |
S  80 +                                                                                                   1 1322
U     |                                                                                                     1 12 2
R     |
V     |                                                                                                       1    1
I  75 +                                                                                                          2 2
V     |                                                                                                        3 3
A     |                                                                                                            1 21
L     |
   70 +                                                                                                          3   21 1
      |                                                                                                              32 11
      |
      |                                                                                                                  13 1
   65 +                                                                                                                 2   2
      |                                                                                                                   3 1
      |
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.

                                                            ACETONITRILE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        50 PPM           = 2
                                                        100 PPM          = 3
                                                        200 PPM          = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                    4                                    2        1                   3
      |                      4                        4           2          2
      |                                                                                        3  3
      |                                               4     4              1 2           1     2  3 3
   95 +                                                     4                 4          1     2  12
      |                                                                       4    4                3       3
      |                                                                                           11  2     33
      |                                                                            4  4               22
   90 +                                                                                            1      1  33
      |                                                                               4 4              2  2
P     |                                                                                                       3  3
E     |                                                                                                   1 1
R  85 +                                                                                                   2  2
C     |                                                                                 4        4          11
E     |                                                                                                      121 33
N     |                                                                                          4         4
T  80 +                                                                                                       21 1
      |                                                                                                    4 4
S     |                                                                                                      44  1 1
U     |                                                                                                            11
R  75 +                                                                                                       4  2  2
V     |                                                                                                           3   3
I     |                                                                                                             1213
V     |                                                                                                          4 4
A  70 +                                                                                                              2  2
L     |                                                                                                            4    22
      |                                                                                                                33
      |                                                                                                               11 2  2
   65 +                                                                                                                  4  4
      |                                                                                                                 33
      |                                                                                                                  33
      |                                                                                                                11
   60 +                                                                                                                 113 3
      |
      |                                                                                                                  1  1
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.