National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2928

TDMS Study 05133-03 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            ACETONITRILE


NTP Experiment-Test: 05133-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12




       Facility:  Battelle Northwest

       Chemical CAS #:  75-05-8

       Lock Date:  05/15/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          56           56           56           56                                     
  Scheduled Sacrifice                                  8            8            8            8                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24           25           21           14                                     
    Accidently Killed                                  1                                                                            
    Natural Death                                                   2            1            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           21           26           29                                     
  Animals Examined Microscopically                    56           56           56           56                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (55)         (55)         (56)         (53)                                   
   Intestine Small, Ileum                             (55)         (55)         (54)         (53)                                   
   Liver                                              (56)         (56)         (56)         (54)                                   
      Fibrous Histiocytoma, Metastatic, Skin                        2 (4%)                                                          
      Hepatocellular Adenoma                                        1 (2%)                                                          
   Mesentery                                          (10)         (9)          (8)          (11)                                   
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                    1 (11%)                                                         
      Lipoma                                                        1 (11%)      1 (13%)                                            
   Pancreas                                           (56)         (56)         (56)         (54)                                   
   Pharynx                                            (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Salivary Glands                                    (56)         (54)         (56)         (55)                                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (56)         (56)         (56)         (55)                                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Heart                                              (56)         (56)         (56)         (55)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (56)         (56)         (56)         (54)                                   
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                    1 (2%)                                                          
   Adrenal Medulla                                    (56)         (55)         (55)         (55)                                   
      Neoplasm NOS                                                                            1 (2%)                                
                                                             Page   2                                                               
NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
   Islets, Pancreatic                                 (56)         (56)         (56)         (54)                                   
      Adenoma                                                                    2 (4%)                                             
      Carcinoma                                                     1 (2%)                    1 (2%)                                
   Parathyroid Gland                                  (52)         (52)         (51)         (52)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
   Pituitary Gland                                    (56)         (56)         (55)         (53)                                   
      Schwannoma Malignant, Metastatic, Brain                                    1 (2%)                                             
      Pars Distalis, Adenoma                          27 (48%)     26 (46%)     30 (55%)     33 (62%)                               
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (56)         (56)         (56)         (54)                                   
      C-Cell, Adenoma                                  3 (5%)       4 (7%)       5 (9%)       5 (9%)                                
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                                      2 (4%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (54)         (50)         (55)         (53)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Carcinoma                                        4 (7%)       1 (2%)       4 (7%)       3 (6%)                                
   Ovary                                              (56)         (56)         (56)         (55)                                   
      Granulosa-Theca Tumor Malignant                               2 (4%)                                                          
   Uterus                                             (56)         (56)         (56)         (55)                                   
      Carcinoma                                                                               1 (2%)                                
      Hemangioma                                                                              1 (2%)                                
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp Stromal                                    7 (13%)      4 (7%)       8 (14%)      6 (11%)                               
      Bilateral, Polyp Stromal                                      1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (56)         (56)         (56)         (54)                                   
   Lymph Node                                         (7)          (6)          (9)          (8)                                    
      Renal, Granulosa-Theca Tumor Malignant,                                                                                       
          Metastatic, Ovary                                         1 (17%)                                                         
   Lymph Node, Bronchial                              (49)         (44)         (45)         (48)                                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Lymph Node, Mandibular                             (54)         (54)         (52)         (49)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Lymph Node, Mesenteric                             (54)         (55)         (55)         (55)                                   
   Lymph Node, Mediastinal                            (56)         (53)         (53)         (54)                                   
      Fibrous Histiocytoma, Metastatic                              1 (2%)                                                          
   Spleen                                             (56)         (56)         (56)         (53)                                   
   Thymus                                             (56)         (56)         (55)         (55)                                   
      Thymoma NOS                                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (56)         (56)         (56)         (55)                                   
      Carcinoma                                        2 (4%)       4 (7%)       3 (5%)       3 (5%)                                
      Fibroadenoma                                    12 (21%)     21 (38%)     18 (32%)     18 (33%)                               
      Fibroadenoma, Multiple                           4 (7%)       6 (11%)      4 (7%)       7 (13%)                               
      Fibrosarcoma                                     1 (2%)                                                                       
   Skin                                               (56)         (56)         (56)         (56)                                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Fibroma                                          1 (2%)       1 (2%)                                                          
      Fibroma, Multiple                                                                       1 (2%)                                
      Fibrous Histiocytoma                                          2 (4%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Trichoepithelioma                                1 (2%)                                                                       
      Pinna, Melanoma NOS                                                        1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (55)         (56)         (56)         (55)                                   
      Schwannoma Malignant, Metastatic, Brain                                    1 (2%)                                             
      Cranium, Carcinoma, Metastatic, Zymbal's                                                                                      
          Gland                                        1 (2%)                                                                       
   Skeletal Muscle                                                 (1)                                                              
      Fibrous Histiocytoma, Metastatic, Skin                        1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (56)         (56)         (56)         (55)                                   
      Astrocytoma NOS                                  1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
      Glioma NOS                                                    1 (2%)       1 (2%)                                             
      Cranial Nerve, Schwannoma Malignant                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (56)         (56)         (56)         (54)                                   
      Alveolar/Bronchiolar Adenoma                                                            2 (4%)                                
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin                        2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (2)          (1)                                                              
      Carcinoma                                        2 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (56)         (56)         (56)         (54)                                   
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                    1 (2%)                                                          
      Lipoma                                                                     1 (2%)                                             
   Urinary Bladder                                    (56)         (56)         (55)         (53)                                   
      Papilloma                                        1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(56)        *(56)        *(56)        *(56)                                   
      Leukemia Mononuclear                            18 (32%)     23 (41%)     20 (36%)     24 (43%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          48          50          51                                       
     Total Primary Neoplasms                           91         108         105         112                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          40          43          43                                       
     Total Benign Neoplasms                            59          71          74          78                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          29          23          28                                       
     Total Malignant Neoplasms                         31          36          29          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           6           1                                                   
     Total Metastatic Neoplasm                          2          16           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1           2           2                                       
     Total Uncertain Neoplasms                          1           1           2           2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          56           56           56           56                                     
  Scheduled Sacrifice                                  8            8            8            8                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                36           26           35           26                                     
    Natural Death                                      1            8            4            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                11           13            9           17                                     
  Other                                                             1                                                               
  Animals Examined Microscopically                    56           56           56           56                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (56)         (50)         (54)         (53)                                   
   Intestine Small, Jejunum                           (55)         (50)         (54)         (52)                                   
      Carcinoma                                                                               1 (2%)                                
      Fibrosarcoma                                     1 (2%)                                                                       
   Intestine Small, Ileum                             (55)         (50)         (54)         (51)                                   
   Liver                                              (56)         (55)         (56)         (56)                                   
      Hepatocellular Carcinoma                         1 (2%)                                 2 (4%)                                
      Hepatocellular Carcinoma, Multiple                                                      1 (2%)                                
      Hepatocellular Adenoma                                        1 (2%)       1 (2%)       3 (5%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Mesentery                                          (10)         (9)          (9)          (12)                                   
   Pancreas                                           (56)         (55)         (56)         (56)                                   
      Adenoma                                                                                 1 (2%)                                
   Pharynx                                                         (1)                       (1)                                    
      Squamous Cell Papilloma                                       1 (100%)                  1 (100%)                              
   Stomach, Forestomach                               (56)         (55)         (56)         (55)                                   
   Stomach, Glandular                                 (56)         (54)         (56)         (55)                                   
   Tongue                                                          (2)                       (1)                                    
      Squamous Cell Carcinoma                                       1 (50%)                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (56)         (55)         (56)         (56)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (56)         (53)         (53)         (56)                                   
      Pheochromocytoma Malignant                                    2 (4%)       2 (4%)       1 (2%)                                
      Pheochromocytoma Benign                          2 (4%)      11 (21%)     10 (19%)      6 (11%)                               
      Bilateral, Pheochromocytoma Benign               2 (4%)       4 (8%)       2 (4%)       1 (2%)                                
   Islets, Pancreatic                                 (56)         (55)         (56)         (56)                                   
      Adenoma                                          1 (2%)       4 (7%)       4 (7%)       1 (2%)                                
      Adenoma, Multiple                                                          1 (2%)                                             
      Carcinoma                                        1 (2%)                    3 (5%)       1 (2%)                                
   Pituitary Gland                                    (56)         (53)         (56)         (54)                                   
      Pars Distalis, Adenoma                          27 (48%)     29 (55%)     25 (45%)     23 (43%)                               
      Pars Intermedia, Adenoma                         2 (4%)                                                                       
   Thyroid Gland                                      (56)         (55)         (56)         (56)                                   
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      Bilateral, C-Cell, Carcinoma                                                            1 (2%)                                
      C-Cell, Adenoma                                  6 (11%)      5 (9%)       7 (13%)      6 (11%)                               
      C-Cell, Carcinoma                                3 (5%)       1 (2%)                                                          
      Follicular Cell, Adenoma                                      1 (2%)                                                          
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (56)         (55)         (56)         (56)                                   
   Preputial Gland                                    (55)         (55)         (55)         (56)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                        5 (9%)       1 (2%)       2 (4%)       1 (2%)                                
   Testes                                             (56)         (55)         (56)         (56)                                   
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Bilateral, Interstitial Cell, Adenoma           28 (50%)     30 (55%)     33 (59%)     42 (75%)                               
      Interstitial Cell, Adenoma                      11 (20%)     13 (24%)     15 (27%)      8 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (56)         (55)         (56)         (56)                                   
   Lymph Node                                         (12)         (8)          (15)         (13)                                   
      Axillary, Osteosarcoma, Metastatic, Bone                                   1 (7%)                                             
   Lymph Node, Bronchial                              (47)         (48)         (46)         (45)                                   
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Lymph Node, Mandibular                             (49)         (51)         (52)         (54)                                   
   Lymph Node, Mesenteric                             (55)         (55)         (55)         (56)                                   
                                                             Page   8                                                               
NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mediastinal                            (56)         (53)         (56)         (56)                                   
   Spleen                                             (56)         (55)         (56)         (56)                                   
      Fibrosarcoma                                                                            1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Sarcoma                                                       2 (4%)                                                          
   Thymus                                             (55)         (52)         (54)         (56)                                   
      Thymoma NOS                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (55)         (56)         (56)                                   
      Carcinoma                                                                  1 (2%)       1 (2%)                                
      Fibroadenoma                                                  2 (4%)                    2 (4%)                                
   Skin                                               (56)         (55)         (56)         (56)                                   
      Basal Cell Adenoma                                            1 (2%)                    1 (2%)                                
      Fibroma                                          3 (5%)       2 (4%)                    3 (5%)                                
      Fibroma, Multiple                                                          1 (2%)                                             
      Fibrosarcoma                                                  1 (2%)                                                          
      Hemangiopericytoma                                                         1 (2%)                                             
      Keratoacanthoma                                  1 (2%)       1 (2%)                    4 (7%)                                
      Trichoepithelioma                                                          1 (2%)                                             
      Sebaceous Gland, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (56)         (55)         (56)         (56)                                   
      Humerus, Osteosarcoma                                                      1 (2%)                                             
      Rib, Osteosarcoma                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (56)         (55)         (56)         (56)                                   
      Astrocytoma NOS                                                                         1 (2%)                                
      Glioma Malignant                                 1 (2%)                                                                       
      Glioma NOS                                                                              1 (2%)                                
      Oligodendroglioma NOS                                         1 (2%)                                                          
      Sarcoma, Metastatic, Spleen                                   1 (2%)                                                          
      Meninges, Meningioma Benign                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (56)         (55)         (56)         (56)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)                    1 (2%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                                                                           
      Pinna, Schwannoma Benign                         1 (50%)                                                                      
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (56)         (55)         (56)         (56)                                   
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (56)         (55)         (56)         (56)                                   
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(56)        *(56)        *(56)        *(56)                                   
      Leukemia Mononuclear                            29 (52%)     32 (57%)     35 (63%)     32 (57%)                               
      Mesothelioma NOS                                 3 (5%)       5 (9%)       2 (4%)       1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05133-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:11:12  
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         FISCHER 344 RATS MALE                     CONTROL      100 PPM      200 PPM      400 PPM                                   
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            56          55          56          56                                       
     Total Primary Neoplasms                          132         153         154         150                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 53          53          53          55                                       
     Total Benign Neoplasms                            86         106         104         102                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              36          36          38          34                                       
     Total Malignant Neoplasms                         43          41          47          45                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1           1           2                                       
     Total Metastatic Neoplasm                          4           1           6           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  3           6           3           3                                       
     Total Uncertain Neoplasms                          7          10           6           6                                       
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.