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TDMS Study 05133-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95       
EXPERIMENT: 05133 TEST: 03                                                                                     TIME: 06:27:19       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 242          
PATHOLOGIST: R. RENNE                                                                                          CAS: 75-05-8         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95       
EXPERIMENT: 05133 TEST: 03                                                                                     TIME: 06:27:19       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 242          
PATHOLOGIST: R. RENNE                                                                                          CAS: 75-05-8         


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95       
EXPERIMENT: 05133 TEST: 03                                                                                     TIME: 06:27:19       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 242          
PATHOLOGIST: R. RENNE                                                                                          CAS: 75-05-8         


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                          IN THE ANALYSIS OF THE STUDY OF ACETONITRILE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Islets, Pancreatic            Carcinoma or Adenoma
              Liver                         Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Skin                          Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
                                             Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
              Testes                        Adenoma
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              ====================================================================================================
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE   1
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/56 (7%)   15/53 (28%)  12/53 (23%)   7/56 (13%) |  1/56 (2%)    2/55 (4%)    2/55 (4%)    2/55 (4%)  |
|ADJUSTED (b)           |  25.0%        56.9%        52.1%        22.1%      |   4.3%         8.9%         6.0%         5.9%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     1/7 (14%)    0/5 (0%)     0/8 (0%)   |  0/8 (0%)     0/7 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  2/11 (18%)   3/13 (23%)   2/9 (22%)    0/17 (0%)  |  1/23 (4%)    1/21 (5%)    1/26 (4%)    1/29 (3%)  |
|FIRST INCIDENCE (DAYS) |   646          456 (I)      507          632       |   734 (T)      719          534          672       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.309N     P=0.015 *    P=0.025 *    P=0.441    |  P=0.519      P=0.456      P=0.542      P=0.576    |
|INCIDENTAL TUMOR       |  P=0.497N     P=0.002 **   P=0.019 *    P=0.315    |  P=0.443      P=0.515      P=0.503      P=0.564    |
|LOGISTIC REGRESSION    |  P=0.432N     P=0.004 **   P=0.020 *    P=0.244    |  P=0.457      P=0.470      P=0.505      P=0.542    |
|COCHRAN-ARMITAGE       |  P=0.536                                           |  P=0.417                                           |
|FISHER EXACT           |               P=0.003 **   P=0.021 *    P=0.264    |               P=0.493      P=0.493      P=0.493    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    2/53 (4%)    2/53 (4%)    1/56 (2%)  |  0/56 (0%)    0/55 (0%)    1/55 (2%)    0/55 (0%)  |
|ADJUSTED (b)           |   0.0%         4.4%         6.0%         5.0%      |   0.0%         0.0%         1.8%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     1/7 (14%)    0/5 (0%)     0/8 (0%)   |  0/8 (0%)     0/7 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          456 (I)      583          727       |   ---          ---          376          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.540      P=0.228      P=0.233      P=0.602    |  P=0.702        (e)        P=0.511        (e)      |
|INCIDENTAL TUMOR       |  P=0.498      P=0.278      P=0.338      P=0.489    |  P=0.605        (e)        P=0.455        (e)      |
|LOGISTIC REGRESSION    |  P=0.446      P=0.221      P=0.225      P=0.580    |  P=0.524        (e)        P=0.306        (e)      |
|COCHRAN-ARMITAGE       |  P=0.474                                           |  P=0.692                                           |
|FISHER EXACT           |               P=0.234      P=0.234      P=0.500    |                 (e)        P=0.495        (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE   2
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/56 (7%)   17/53 (32%)  14/53 (26%)   8/56 (14%) |  1/56 (2%)    2/55 (4%)    3/55 (5%)    2/55 (4%)  |
|ADJUSTED (b)           |  25.0%        58.8%        55.0%        26.2%      |   4.3%         8.9%         7.7%         5.9%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     2/7 (29%)    0/5 (0%)     0/8 (0%)   |  0/8 (0%)     0/7 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  2/11 (18%)   3/13 (23%)   2/9 (22%)    0/17 (0%)  |  1/23 (4%)    1/21 (5%)    1/26 (4%)    1/29 (3%)  |
|FIRST INCIDENCE (DAYS) |   646          456 (I)      507          632       |   734 (T)      719          376          672       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.342N     P=0.006 **   P=0.010 **   P=0.358    |  P=0.498      P=0.456      P=0.346      P=0.576    |
|INCIDENTAL TUMOR       |  P=0.544N     P<0.001 **   P=0.009 **   P=0.214    |  P=0.384      P=0.515      P=0.283      P=0.564    |
|LOGISTIC REGRESSION    |  P=0.522N     P=0.001 **   P=0.006 **   P=0.173    |  P=0.407      P=0.470      P=0.275      P=0.542    |
|COCHRAN-ARMITAGE       |  P=0.479                                           |  P=0.398                                           |
|FISHER EXACT           |               P<0.001 **   P=0.006 **   P=0.180    |               P=0.493      P=0.302      P=0.493    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/55 (0%)    0/55 (0%)    1/55 (2%)    0/56 (0%)  |  1/54 (2%)    1/50 (2%)    1/55 (2%)    3/53 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%        11.1%         0.0%      |   4.5%         2.3%         3.8%        10.7%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    1/9 (11%)    0/17 (0%)  |  1/22 (5%)    0/21 (0%)    1/26 (4%)    3/28 (11%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          733 (T)      ---       |   734 (T)      600          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.732        (e)        P=0.460        (e)      |  P=0.231      P=0.749N     P=0.725N     P=0.393    |
|INCIDENTAL TUMOR       |  P=0.732        (e)        P=0.460        (e)      |  P=0.223      P=0.741N     P=0.725N     P=0.393    |
|LOGISTIC REGRESSION    |  P=0.732        (e)        P=0.460        (e)      |  P=0.199      P=0.754      P=0.725N     P=0.393    |
|COCHRAN-ARMITAGE       |  P=0.696                                           |  P=0.166                                           |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.733      P=0.748N     P=0.302    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE   3
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/55 (9%)    1/55 (2%)    2/55 (4%)    1/56 (2%)  |  4/54 (7%)    1/50 (2%)    4/55 (7%)    3/53 (6%)  |
|ADJUSTED (b)           |  15.8%         2.9%         8.7%         2.1%      |  14.7%         2.3%        15.4%         8.9%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     1/8 (13%)  |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     0/17 (0%)  |  2/22 (9%)    0/21 (0%)    4/26 (15%)   2/28 (7%)  |
|FIRST INCIDENCE (DAYS) |   472          567          665          485       |   623          588          734 (T)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.075N     P=0.112N     P=0.257N     P=0.081N   |  P=0.461N     P=0.192N     P=0.576N     P=0.407N   |
|INCIDENTAL TUMOR       |  P=0.139N     P=0.131N     P=0.232N     P=0.286N   |  P=0.480N     P=0.152N     P=0.548N     P=0.426N   |
|LOGISTIC REGRESSION    |  P=0.097N     P=0.101N     P=0.218N     P=0.126N   |  P=0.528N     P=0.188N     P=0.635N     P=0.469N   |
|COCHRAN-ARMITAGE       |  P=0.090N                                          |  P=0.575N                                          |
|FISHER EXACT           |               P=0.103N     P=0.219N     P=0.099N   |               P=0.206N     P=0.632N     P=0.511N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/55 (9%)    1/55 (2%)    3/55 (5%)    1/56 (2%)  |  5/54 (9%)    2/50 (4%)    5/55 (9%)    6/53 (11%) |
|ADJUSTED (b)           |  15.8%         2.9%        18.8%         2.1%      |  19.0%         4.5%        19.2%        19.4%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     1/8 (13%)  |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    1/9 (11%)    0/17 (0%)  |  3/22 (14%)   0/21 (0%)    5/26 (19%)   5/28 (18%) |
|FIRST INCIDENCE (DAYS) |   472          567          665          485       |   623          588          734 (T)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.087N     P=0.112N     P=0.413N     P=0.081N   |  P=0.424      P=0.224N     P=0.547N     P=0.615N   |
|INCIDENTAL TUMOR       |  P=0.157N     P=0.131N     P=0.391N     P=0.286N   |  P=0.403      P=0.175N     P=0.521N     P=0.621    |
|LOGISTIC REGRESSION    |  P=0.115N     P=0.101N     P=0.367N     P=0.126N   |  P=0.345      P=0.229N     P=0.623N     P=0.564    |
|COCHRAN-ARMITAGE       |  P=0.111N                                          |  P=0.285                                           |
|FISHER EXACT           |               P=0.103N     P=0.358N     P=0.099N   |               P=0.251N     P=0.617N     P=0.487    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE   4
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    4/55 (7%)    5/56 (9%)    1/56 (2%)  |  0/56 (0%)    0/56 (0%)    2/56 (4%)    0/54 (0%)  |
|ADJUSTED (b)           |   3.6%        18.9%        22.8%         5.9%      |   0.0%         0.0%         7.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    1/13 (8%)    0/9 (0%)     1/17 (6%)  |  0/23 (0%)    0/21 (0%)    2/26 (8%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   651          559          539          733 (T)   |   ---          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.357N     P=0.196      P=0.090      P=0.697N   |  P=0.649        (e)        P=0.265        (e)      |
|INCIDENTAL TUMOR       |  P=0.465N     P=0.207      P=0.074      P=0.720N   |  P=0.649        (e)        P=0.265        (e)      |
|LOGISTIC REGRESSION    |  P=0.417N     P=0.176      P=0.096      P=0.722N   |  P=0.649        (e)        P=0.265        (e)      |
|COCHRAN-ARMITAGE       |  P=0.476N                                          |  P=0.588                                           |
|FISHER EXACT           |               P=0.176      P=0.103      P=0.752N   |                 (e)        P=0.248        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    0/55 (0%)    3/56 (5%)    1/56 (2%)  |  0/56 (0%)    1/56 (2%)    0/56 (0%)    1/54 (2%)  |
|ADJUSTED (b)           |   5.9%         0.0%         9.8%         5.9%      |   0.0%         3.8%         0.0%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     1/17 (6%)  |  0/23 (0%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   693          ---          560          733 (T)   |   ---          713          ---          670       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.555      P=0.468N     P=0.295      P=0.676N   |  P=0.445      P=0.478        (e)        P=0.545    |
|INCIDENTAL TUMOR       |  P=0.517      P=0.581N     P=0.362      P=0.720N   |  P=0.395      P=0.562        (e)        P=0.517    |
|LOGISTIC REGRESSION    |  P=0.502      P=0.497N     P=0.299      P=0.701N   |  P=0.420      P=0.503        (e)        P=0.505    |
|COCHRAN-ARMITAGE       |  P=0.472                                           |  P=0.397                                           |
|FISHER EXACT           |               P=0.505N     P=0.309      P=0.752N   |               P=0.500        (e)        P=0.491    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE   5
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/56 (4%)    4/55 (7%)    8/56 (14%)   2/56 (4%)  |  0/56 (0%)    1/56 (2%)    2/56 (4%)    1/54 (2%)  |
|ADJUSTED (b)           |   9.2%        18.9%        30.4%        11.8%      |   0.0%         3.8%         7.7%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    1/13 (8%)    0/9 (0%)     2/17 (12%) |  0/23 (0%)    0/21 (0%)    2/26 (8%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   651          559          539          733 (T)   |   ---          713          734 (T)      670       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.413N     P=0.367      P=0.045 *    P=0.572N   |  P=0.437      P=0.478      P=0.265      P=0.545    |
|INCIDENTAL TUMOR       |  P=0.530N     P=0.341      P=0.042 *    P=0.627N   |  P=0.403      P=0.562      P=0.265      P=0.517    |
|LOGISTIC REGRESSION    |  P=0.498N     P=0.333      P=0.044 *    P=0.613N   |  P=0.401      P=0.503      P=0.265      P=0.505    |
|COCHRAN-ARMITAGE       |  P=0.566N                                          |  P=0.355                                           |
|FISHER EXACT           |               P=0.331      P=0.047 *    P=0.691N   |               P=0.500      P=0.248      P=0.491    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    1/55 (2%)    1/56 (2%)    3/56 (5%)  |  0/56 (0%)    1/56 (2%)    0/56 (0%)    0/54 (0%)  |
|ADJUSTED (b)           |   0.0%         3.4%         4.8%        16.2%      |   0.0%         4.8%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     2/17 (12%) |  0/23 (0%)    1/21 (5%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          623          673          727       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.110      P=0.480      P=0.465      P=0.214    |  P=0.524N     P=0.482        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.083      P=0.615      P=0.477      P=0.171    |  P=0.524N     P=0.482        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.085      P=0.497      P=0.490      P=0.204    |  P=0.524N     P=0.482        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.055                                           |  P=0.573N                                          |
|FISHER EXACT           |               P=0.495      P=0.500      P=0.122    |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE   6
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    0/55 (0%)    0/56 (0%)    3/56 (5%)  |  0/56 (0%)    0/56 (0%)    0/56 (0%)    0/54 (0%)  |
|ADJUSTED (b)           |   3.3%         0.0%         0.0%        14.5%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     1/17 (6%)  |  0/23 (0%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   637          ---          ---          693       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.150      P=0.514N     P=0.514N     P=0.438    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.112      P=0.385N     P=0.412N     P=0.361    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.123      P=0.503N     P=0.504N     P=0.380    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.087                                           |    (e)                                             |
|FISHER EXACT           |               P=0.505N     P=0.500N     P=0.309    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    1/55 (2%)    1/56 (2%)    5/56 (9%)  |  0/56 (0%)    1/56 (2%)    0/56 (0%)    0/54 (0%)  |
|ADJUSTED (b)           |   3.3%         3.4%         4.8%        25.2%      |   0.0%         4.8%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     3/17 (18%) |  0/23 (0%)    1/21 (5%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   637          623          673          693       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.067      P=0.742      P=0.733      P=0.213    |  P=0.524N     P=0.482        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.046 *    P=0.630N     P=0.727N     P=0.168    |  P=0.524N     P=0.482        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.047 *    P=0.759      P=0.755      P=0.166    |  P=0.524N     P=0.482        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.026 *                                         |  P=0.573N                                          |
|FISHER EXACT           |               P=0.748      P=0.752N     P=0.103    |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE   7
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    1/55 (2%)    1/56 (2%)    5/56 (9%)  |  0/56 (0%)    1/56 (2%)    0/56 (0%)    0/54 (0%)  |
|ADJUSTED (b)           |   3.3%         3.4%         4.8%        25.2%      |   0.0%         4.8%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     3/17 (18%) |  0/23 (0%)    1/21 (5%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   637          623          673          693       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.067      P=0.742      P=0.733      P=0.213    |  P=0.524N     P=0.482        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.046 *    P=0.630N     P=0.727N     P=0.168    |  P=0.524N     P=0.482        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.047 *    P=0.759      P=0.755      P=0.166    |  P=0.524N     P=0.482        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.026 *                                         |  P=0.573N                                          |
|FISHER EXACT           |               P=0.748      P=0.752N     P=0.103    |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    1/55 (2%)    0/56 (0%)    0/56 (0%)  |  0/56 (0%)    0/56 (0%)    0/56 (0%)    2/54 (4%)  |
|ADJUSTED (b)           |   4.2%         5.6%         0.0%         0.0%      |   0.0%         0.0%         0.0%         6.9%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    0/21 (0%)    0/26 (0%)    2/29 (7%)  |
|FIRST INCIDENCE (DAYS) |   679          707          ---          ---       |   ---          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.205N     P=0.743N     P=0.547N     P=0.469N   |  P=0.068        (e)          (e)        P=0.290    |
|INCIDENTAL TUMOR       |  P=0.235N     P=0.670      P=0.523N     P=0.511N   |  P=0.068        (e)          (e)        P=0.290    |
|LOGISTIC REGRESSION    |  P=0.210N     P=0.761N     P=0.512N     P=0.471N   |  P=0.068        (e)          (e)        P=0.290    |
|COCHRAN-ARMITAGE       |  P=0.235N                                          |  P=0.044 *                                         |
|FISHER EXACT           |               P=0.748      P=0.500N     P=0.500N   |                 (e)          (e)        P=0.239    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE   8
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/56 (4%)    2/55 (4%)    1/56 (2%)    0/56 (0%)  |  0/56 (0%)    0/56 (0%)    0/56 (0%)    2/54 (4%)  |
|ADJUSTED (b)           |  12.9%        12.8%         1.8%         0.0%      |   0.0%         0.0%         0.0%         6.9%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  1/11 (9%)    1/13 (8%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    0/21 (0%)    0/26 (0%)    2/29 (7%)  |
|FIRST INCIDENCE (DAYS) |   679          707          371          ---       |   ---          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.095N     P=0.649N     P=0.550N     P=0.177N   |  P=0.068        (e)          (e)        P=0.290    |
|INCIDENTAL TUMOR       |  P=0.131N     P=0.654      P=0.549N     P=0.198N   |  P=0.068        (e)          (e)        P=0.290    |
|LOGISTIC REGRESSION    |  P=0.106N     P=0.679N     P=0.430N     P=0.183N   |  P=0.068        (e)          (e)        P=0.290    |
|COCHRAN-ARMITAGE       |  P=0.125N                                          |  P=0.044 *                                         |
|FISHER EXACT           |               P=0.684      P=0.500N     P=0.248N   |                 (e)          (e)        P=0.239    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    0/55 (0%)    1/56 (2%)    1/56 (2%)  |  2/56 (4%)    4/56 (7%)    3/56 (5%)    3/56 (5%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.5%         5.9%      |   8.7%        13.4%        11.5%         8.8%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     1/17 (6%)  |  2/23 (9%)    1/21 (5%)    3/26 (12%)   1/29 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          666          733 (T)   |   734 (T)      671          734 (T)      672       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.304        (e)        P=0.474      P=0.587    |  P=0.536N     P=0.319      P=0.557      P=0.589    |
|INCIDENTAL TUMOR       |  P=0.287        (e)        P=0.477      P=0.587    |  P=0.577      P=0.387      P=0.557      P=0.579    |
|LOGISTIC REGRESSION    |  P=0.282        (e)        P=0.491      P=0.587    |  P=0.570      P=0.348      P=0.557      P=0.561    |
|COCHRAN-ARMITAGE       |  P=0.237                                           |  P=0.500                                           |
|FISHER EXACT           |                 (e)        P=0.500      P=0.500    |               P=0.339      P=0.500      P=0.500    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE   9
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    2/55 (4%)    0/56 (0%)    2/56 (4%)  | 16/56 (29%)  27/56 (48%)  22/56 (39%)  25/56 (45%) |
|ADJUSTED (b)           |   0.0%        15.4%         0.0%        10.6%      |  55.9%        72.7%        60.8%        62.5%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     1/8 (13%)    2/8 (25%)  |
|TERMINAL (d)           |  0/11 (0%)    2/13 (15%)   0/9 (0%)     1/17 (6%)  | 11/23 (48%)  12/21 (57%)  13/26 (50%)  15/29 (52%) |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      ---          727       |   525          478          457 (I)      394       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.372      P=0.273        (e)        P=0.348    |  P=0.449      P=0.022 *    P=0.255      P=0.221    |
|INCIDENTAL TUMOR       |  P=0.339      P=0.273        (e)        P=0.280    |  P=0.235      P=0.034 *    P=0.230      P=0.131    |
|LOGISTIC REGRESSION    |  P=0.365      P=0.273        (e)        P=0.335    |  P=0.215      P=0.032 *    P=0.168      P=0.113    |
|COCHRAN-ARMITAGE       |  P=0.249                                           |  P=0.125                                           |
|FISHER EXACT           |               P=0.243        (e)        P=0.248    |               P=0.026 *    P=0.159      P=0.058    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    2/55 (4%)    1/56 (2%)    3/56 (5%)  | 17/56 (30%)  30/56 (54%)  24/56 (43%)  26/56 (46%) |
|ADJUSTED (b)           |   0.0%        15.4%         4.5%        16.2%      |  59.6%        77.2%        66.8%        65.2%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     1/8 (13%)    2/8 (25%)  |
|TERMINAL (d)           |  0/11 (0%)    2/13 (15%)   0/9 (0%)     2/17 (12%) | 12/23 (52%)  13/21 (62%)  15/26 (58%)  16/29 (55%) |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      666          727       |   525          478          457 (I)      394       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.202      P=0.273      P=0.474      P=0.214    |  P=0.521      P=0.010 *    P=0.206      P=0.234    |
|INCIDENTAL TUMOR       |  P=0.173      P=0.273      P=0.477      P=0.171    |  P=0.297      P=0.014 *    P=0.181      P=0.141    |
|LOGISTIC REGRESSION    |  P=0.178      P=0.273      P=0.491      P=0.204    |  P=0.269      P=0.012 *    P=0.122      P=0.120    |
|COCHRAN-ARMITAGE       |  P=0.105                                           |  P=0.153                                           |
|FISHER EXACT           |               P=0.243      P=0.500      P=0.122    |               P=0.011 *    P=0.120      P=0.060    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  10
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    2/55 (4%)    0/56 (0%)    2/56 (4%)  |  1/56 (2%)    0/56 (0%)    0/56 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |   0.0%        14.3%         0.0%        11.8%      |   4.3%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    1/13 (8%)    0/9 (0%)     2/17 (12%) |  1/23 (4%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          732          ---          733 (T)   |   734 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.362      P=0.286        (e)        P=0.337    |  P=0.275N     P=0.518N     P=0.476N     P=0.454N   |
|INCIDENTAL TUMOR       |  P=0.339      P=0.212        (e)        P=0.337    |  P=0.275N     P=0.518N     P=0.476N     P=0.454N   |
|LOGISTIC REGRESSION    |  P=0.361      P=0.278        (e)        P=0.337    |  P=0.275N     P=0.518N     P=0.476N     P=0.454N   |
|COCHRAN-ARMITAGE       |  P=0.249                                           |  P=0.306N                                          |
|FISHER EXACT           |               P=0.243        (e)        P=0.248    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Granulosa-Theca Tumor Malignant                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/56 (0%)    2/56 (4%)    0/56 (0%)    0/55 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         6.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |                                                    |  0/23 (0%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          517          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.384N     P=0.238        (e)          (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.484N     P=0.214        (e)          (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.421N     P=0.229        (e)          (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.409N                                          |
|FISHER EXACT           |                                                    |               P=0.248        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  11
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/56 (48%)  29/53 (55%)  25/56 (45%)  23/54 (43%) | 27/56 (48%)  26/56 (46%)  30/55 (55%)  33/53 (62%) |
|ADJUSTED (b)           |  73.0%        88.9%        83.4%        68.2%      |  71.6%        73.0%        76.1%        79.5%      |
|INTERIM SACRIFICE 1 (c)|  2/8 (25%)    2/7 (29%)    2/8 (25%)    0/7 (0%)   |  3/8 (38%)    0/8 (0%)     2/8 (25%)    4/8 (50%)  |
|TERMINAL (d)           |  4/11 (36%)  10/13 (77%)   6/9 (67%)    8/17 (47%) | 13/23 (57%)  12/21 (57%)  17/26 (65%)  21/29 (72%) |
|FIRST INCIDENCE (DAYS) |   394          331          371          485       |   457 (I)      600          457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.044N*    P=0.523      P=0.542      P=0.082N   |  P=0.491      P=0.520      P=0.491      P=0.517    |
|INCIDENTAL TUMOR       |  P=0.195N     P=0.279      P=0.497N     P=0.362N   |  P=0.165      P=0.280N     P=0.437      P=0.298    |
|LOGISTIC REGRESSION    |  P=0.139N     P=0.325      P=0.435N     P=0.258N   |  P=0.129      P=0.378N     P=0.379      P=0.215    |
|COCHRAN-ARMITAGE       |  P=0.207N                                          |  P=0.052                                           |
|FISHER EXACT           |               P=0.313      P=0.425N     P=0.345N   |               P=0.500N     P=0.317      P=0.100    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/56 (4%)    0/53 (0%)    0/56 (0%)    0/54 (0%)  |  0/56 (0%)    1/56 (2%)    0/55 (0%)    0/53 (0%)  |
|ADJUSTED (b)           |   4.2%         0.0%         0.0%         0.0%      |   0.0%         4.8%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    0/7 (0%)     0/8 (0%)     0/7 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    1/21 (5%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      ---          ---          ---       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.116N     P=0.249N     P=0.240N     P=0.241N   |  P=0.524N     P=0.482        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.157N     P=0.331N     P=0.251N     P=0.415N   |  P=0.524N     P=0.482        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.132N     P=0.245N     P=0.215N     P=0.341N   |  P=0.524N     P=0.482        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.117N                                          |  P=0.576N                                          |
|FISHER EXACT           |               P=0.262N     P=0.248N     P=0.257N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  12
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    2/55 (4%)    1/56 (2%)    5/56 (9%)  |  2/56 (4%)    0/56 (0%)    0/56 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |   1.9%        13.1%         4.5%        27.4%      |   8.7%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    1/13 (8%)    0/9 (0%)     4/17 (24%) |  2/23 (9%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      718          666          727       |   734 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.118      P=0.550      P=0.746      P=0.206    |  P=0.094N     P=0.257N     P=0.211N     P=0.188N   |
|INCIDENTAL TUMOR       |  P=0.092      P=0.473      P=0.747      P=0.175    |  P=0.094N     P=0.257N     P=0.211N     P=0.188N   |
|LOGISTIC REGRESSION    |  P=0.081      P=0.495      P=0.756N     P=0.138    |  P=0.094N     P=0.257N     P=0.211N     P=0.188N   |
|COCHRAN-ARMITAGE       |  P=0.049 *                                         |  P=0.115N                                          |
|FISHER EXACT           |               P=0.493      P=0.752N     P=0.103    |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/56 (5%)    2/55 (4%)    1/56 (2%)    3/56 (5%)  |  1/56 (2%)    1/56 (2%)    0/56 (0%)    1/56 (2%)  |
|ADJUSTED (b)           |  17.3%        12.6%         7.7%        10.4%      |   2.8%         4.8%         0.0%         3.4%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  1/11 (9%)    1/13 (8%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    1/21 (5%)    0/26 (0%)    1/29 (3%)  |
|FIRST INCIDENCE (DAYS) |   602          701          707          560       |   625          734 (T)      ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.471N     P=0.448N     P=0.347N     P=0.527N   |  P=0.553N     P=0.753      P=0.500N     P=0.717N   |
|INCIDENTAL TUMOR       |  P=0.549N     P=0.491N     P=0.306N     P=0.597N   |  P=0.577N     P=0.720N     P=0.406N     P=0.735N   |
|LOGISTIC REGRESSION    |  P=0.534N     P=0.494N     P=0.327N     P=0.614N   |  P=0.588N     P=0.753N     P=0.501N     P=0.746N   |
|COCHRAN-ARMITAGE       |  P=0.571                                           |  P=0.616N                                          |
|FISHER EXACT           |               P=0.509N     P=0.309N     P=0.661N   |               P=0.752N     P=0.500N     P=0.752N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  13
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/56 (5%)    3/55 (5%)    1/56 (2%)    3/56 (5%)  |  2/56 (4%)    3/56 (5%)    0/56 (0%)    1/56 (2%)  |
|ADJUSTED (b)           |  17.3%        19.8%         7.7%        10.4%      |   4.5%        12.8%         0.0%         3.4%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  1/11 (9%)    2/13 (15%)   0/9 (0%)     0/17 (0%)  |  0/23 (0%)    2/21 (10%)   0/26 (0%)    1/29 (3%)  |
|FIRST INCIDENCE (DAYS) |   602          701          707          560       |   310          706          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.394N     P=0.603N     P=0.347N     P=0.527N   |  P=0.199N     P=0.479      P=0.240N     P=0.454N   |
|INCIDENTAL TUMOR       |  P=0.463N     P=0.645N     P=0.306N     P=0.597N   |  P=0.313N     P=0.443      P=0.308N     P=0.735N   |
|LOGISTIC REGRESSION    |  P=0.453N     P=0.657N     P=0.327N     P=0.614N   |  P=0.242N     P=0.491      P=0.300N     P=0.583N   |
|COCHRAN-ARMITAGE       |  P=0.541N                                          |  P=0.242N                                          |
|FISHER EXACT           |               P=0.652      P=0.309N     P=0.661N   |               P=0.500      P=0.248N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    1/55 (2%)    0/56 (0%)    0/56 (0%)  |  1/56 (2%)    2/56 (4%)    0/56 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |   0.0%         7.7%         0.0%         0.0%      |   1.8%         8.2%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    1/13 (8%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    1/21 (5%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      ---          ---       |   310          706          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.505N     P=0.533        (e)          (e)      |  P=0.173N     P=0.480      P=0.500N     P=0.496N   |
|INCIDENTAL TUMOR       |  P=0.505N     P=0.533        (e)          (e)      |  P=0.308N     P=0.381      P=0.773N       (e)      |
|LOGISTIC REGRESSION    |  P=0.505N     P=0.533        (e)          (e)      |  P=0.211N     P=0.466      P=0.713N     P=0.799N   |
|COCHRAN-ARMITAGE       |  P=0.566N                                          |  P=0.188N                                          |
|FISHER EXACT           |               P=0.495        (e)          (e)      |               P=0.500      P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  14
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrous Histiocytoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    0/55 (0%)    0/56 (0%)    0/56 (0%)  |  0/56 (0%)    2/56 (4%)    0/56 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         8.2%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    1/21 (5%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          706          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.371N     P=0.219        (e)          (e)      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.383N     P=0.263        (e)          (e)      |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.378N     P=0.233        (e)          (e)      |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.405N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.248        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    1/55 (2%)    0/56 (0%)    4/56 (7%)  |  0/56 (0%)    0/56 (0%)    0/56 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |   1.9%         5.9%         0.0%        23.5%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     4/17 (24%) |  0/23 (0%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      718          ---          733 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.123      P=0.731N     P=0.500N     P=0.293    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.111      P=0.716      P=0.500N     P=0.293    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.093      P=0.758      P=0.468N     P=0.222    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.063                                           |    (e)                                             |
|FISHER EXACT           |               P=0.748      P=0.500N     P=0.182    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  15
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Basal Cell Carcinoma, Basosquamous Tumor                                                           |
|     (malignant or NOS), or Carcinoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    0/55 (0%)    0/56 (0%)    0/56 (0%)  |  2/56 (4%)    0/56 (0%)    0/56 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.7%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     0/17 (0%)  |  2/23 (9%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   734 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.094N     P=0.257N     P=0.211N     P=0.188N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.094N     P=0.257N     P=0.211N     P=0.188N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.094N     P=0.257N     P=0.211N     P=0.188N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.115N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/56 (2%)    1/55 (2%)    0/56 (0%)    4/56 (7%)  |  1/56 (2%)    0/56 (0%)    0/56 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |   1.9%         5.9%         0.0%        23.5%      |   4.3%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/8 (13%)    0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     4/17 (24%) |  1/23 (4%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      718          ---          733 (T)   |   734 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.123      P=0.731N     P=0.500N     P=0.293    |  P=0.275N     P=0.518N     P=0.476N     P=0.454N   |
|INCIDENTAL TUMOR       |  P=0.111      P=0.716      P=0.500N     P=0.293    |  P=0.275N     P=0.518N     P=0.476N     P=0.454N   |
|LOGISTIC REGRESSION    |  P=0.093      P=0.758      P=0.468N     P=0.222    |  P=0.275N     P=0.518N     P=0.476N     P=0.454N   |
|COCHRAN-ARMITAGE       |  P=0.063                                           |  P=0.306N                                          |
|FISHER EXACT           |               P=0.748      P=0.500N     P=0.182    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  16
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    2/55 (4%)    0/56 (0%)    0/56 (0%)  |  0/56 (0%)    0/56 (0%)    0/56 (0%)    0/53 (0%)  |
|ADJUSTED (b)           |   0.0%        10.6%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    1/13 (8%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    0/21 (0%)    0/26 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          588          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.352N     P=0.248        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.355N     P=0.323        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.384N     P=0.236        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.404N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.243        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 39/56 (70%)  43/55 (78%)  48/56 (86%)  50/56 (89%) |                                                    |
|ADJUSTED (b)           |  97.2%       100.0%       100.0%       100.0%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  6/8 (75%)    8/8 (100%)   8/8 (100%)   8/8 (100%) |                                                    |
|TERMINAL (d)           | 10/11 (91%)  13/13 (100%)  9/9 (100%)  17/17 (100%)|                                                    |
|FIRST INCIDENCE (DAYS) |   456 (I)      446          395          456 (I)   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.497N     P=0.508      P=0.054      P=0.517N   |                                                    |
|INCIDENTAL TUMOR       |  P=0.031 *    P=0.220      P=0.018 *    P=0.075    |                                                    |
|LOGISTIC REGRESSION    |  P=0.010 *    P=0.204      P=0.019 *    P=0.020 *  |                                                    |
|COCHRAN-ARMITAGE       |  P=0.005 **                                        |                                                    |
|FISHER EXACT           |               P=0.210      P=0.034 *    P=0.009 ** |                                                    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  17
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/56 (11%)   5/55 (9%)    8/56 (14%)   6/56 (11%) |  3/56 (5%)    4/56 (7%)    5/56 (9%)    5/54 (9%)  |
|ADJUSTED (b)           |  31.1%        25.5%        37.0%        27.3%      |  10.5%        18.2%        17.0%        14.9%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     1/8 (13%)    0/8 (0%)   |  0/8 (0%)     0/8 (0%)     1/8 (13%)    1/8 (13%)  |
|TERMINAL (d)           |  2/11 (18%)   2/13 (15%)   2/9 (22%)    3/17 (18%) |  1/23 (4%)    3/21 (14%)   4/26 (15%)   3/29 (10%) |
|FIRST INCIDENCE (DAYS) |   646          525          456 (I)      672       |   702          721          457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.397N     P=0.432N     P=0.316      P=0.379N   |  P=0.428      P=0.429      P=0.389      P=0.448    |
|INCIDENTAL TUMOR       |  P=0.515N     P=0.605      P=0.375      P=0.516N   |  P=0.393      P=0.544      P=0.372      P=0.441    |
|LOGISTIC REGRESSION    |  P=0.510N     P=0.500N     P=0.361      P=0.465N   |  P=0.335      P=0.477      P=0.367      P=0.396    |
|COCHRAN-ARMITAGE       |  P=0.491                                           |  P=0.269                                           |
|FISHER EXACT           |               P=0.513N     P=0.388      P=0.619N   |               P=0.500      P=0.358      P=0.338    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/56 (5%)    1/55 (2%)    0/56 (0%)    1/56 (2%)  |  0/56 (0%)    1/56 (2%)    0/56 (0%)    0/54 (0%)  |
|ADJUSTED (b)           |  10.7%         7.7%         0.0%         5.9%      |   0.0%         4.8%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    1/13 (8%)    0/9 (0%)     1/17 (6%)  |  0/23 (0%)    1/21 (5%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   511          733 (T)      ---          733 (T)   |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.161N     P=0.299N     P=0.150N     P=0.239N   |  P=0.524N     P=0.482        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.206N     P=0.428N     P=0.143N     P=0.396N   |  P=0.524N     P=0.482        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.174N     P=0.309N     P=0.123N     P=0.280N   |  P=0.524N     P=0.482        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.199N                                          |  P=0.573N                                          |
|FISHER EXACT           |               P=0.316N     P=0.122N     P=0.309N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  18
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/56 (16%)   6/55 (11%)   8/56 (14%)   7/56 (13%) |  3/56 (5%)    5/56 (9%)    5/56 (9%)    5/54 (9%)  |
|ADJUSTED (b)           |  38.4%        32.3%        37.0%        32.5%      |  10.5%        22.7%        17.0%        14.9%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     1/8 (13%)    0/8 (0%)   |  0/8 (0%)     0/8 (0%)     1/8 (13%)    1/8 (13%)  |
|TERMINAL (d)           |  2/11 (18%)   3/13 (23%)   2/9 (22%)    4/17 (24%) |  1/23 (4%)    4/21 (19%)   4/26 (15%)   3/29 (10%) |
|FIRST INCIDENCE (DAYS) |   511          525          456 (I)      672       |   702          721          457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.217N     P=0.244N     P=0.595N     P=0.184N   |  P=0.488      P=0.291      P=0.389      P=0.448    |
|INCIDENTAL TUMOR       |  P=0.325N     P=0.482N     P=0.529N     P=0.348N   |  P=0.454      P=0.388      P=0.372      P=0.441    |
|LOGISTIC REGRESSION    |  P=0.301N     P=0.288N     P=0.525N     P=0.254N   |  P=0.391      P=0.325      P=0.367      P=0.396    |
|COCHRAN-ARMITAGE       |  P=0.416N                                          |  P=0.316                                           |
|FISHER EXACT           |               P=0.303N     P=0.500N     P=0.394N   |               P=0.358      P=0.358      P=0.338    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    1/55 (2%)    0/56 (0%)    0/56 (0%)  |  0/56 (0%)    2/56 (4%)    0/56 (0%)    0/54 (0%)  |
|ADJUSTED (b)           |   0.0%         7.7%         0.0%         0.0%      |   0.0%         7.5%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    1/13 (8%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    1/21 (5%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      ---          ---       |   ---          665          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.505N     P=0.533        (e)          (e)      |  P=0.359N     P=0.236        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.505N     P=0.533        (e)          (e)      |  P=0.383N     P=0.263        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.505N     P=0.533        (e)          (e)      |  P=0.388N     P=0.245        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.566N                                          |  P=0.412N                                          |
|FISHER EXACT           |               P=0.495        (e)          (e)      |               P=0.248        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  19
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    1/55 (2%)    1/56 (2%)    0/56 (0%)  |  1/56 (2%)    2/56 (4%)    0/56 (0%)    0/54 (0%)  |
|ADJUSTED (b)           |   0.0%         7.7%         5.0%         0.0%      |   2.0%         7.5%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    1/13 (8%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    1/21 (5%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      674          ---       |   427          665          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.534N     P=0.533      P=0.455        (e)      |  P=0.163N     P=0.505      P=0.489N     P=0.485N   |
|INCIDENTAL TUMOR       |  P=0.544N     P=0.533      P=0.477        (e)      |  P=0.214N     P=0.467      P=0.545N     P=0.682N   |
|LOGISTIC REGRESSION    |  P=0.542N     P=0.533      P=0.490        (e)      |  P=0.205N     P=0.485      P=0.596N     P=0.661N   |
|COCHRAN-ARMITAGE       |  P=0.593N                                          |  P=0.193N                                          |
|FISHER EXACT           |               P=0.495      P=0.500        (e)      |               P=0.500      P=0.500N     P=0.509N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  7/56 (13%)   5/56 (9%)   10/56 (18%)   6/56 (11%) |
|ADJUSTED (b)           |                                                    |  27.5%        15.9%        31.8%        18.1%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/8 (0%)     1/8 (13%)    1/8 (13%)    1/8 (13%)  |
|TERMINAL (d)           |                                                    |  6/23 (26%)   2/21 (10%)   7/26 (27%)   4/29 (14%) |
|FIRST INCIDENCE (DAYS) |                                                    |   331          457 (I)      457 (I)      457 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.369N     P=0.414N     P=0.378      P=0.351N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.488N     P=0.448N     P=0.322      P=0.475N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.506N     P=0.357N     P=0.316      P=0.438N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.554                                           |
|FISHER EXACT           |                                                    |               P=0.381N     P=0.300      P=0.500N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  20
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/56 (0%)    0/55 (0%)    0/56 (0%)    1/56 (2%)  |  2/56 (4%)    1/56 (2%)    0/56 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         2.6%      |   5.4%         2.2%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    0/13 (0%)    0/9 (0%)     0/17 (0%)  |  0/23 (0%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          597       |   588          517          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.226        (e)          (e)        P=0.522    |  P=0.092N     P=0.472N     P=0.243N     P=0.207N   |
|INCIDENTAL TUMOR       |  P=0.194        (e)          (e)        P=0.557    |  P=0.124N     P=0.468N     P=0.208N     P=0.230N   |
|LOGISTIC REGRESSION    |  P=0.190        (e)          (e)        P=0.484    |  P=0.112N     P=0.530N     P=0.238N     P=0.243N   |
|COCHRAN-ARMITAGE       |  P=0.200                                           |  P=0.101N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.500    |               P=0.500N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 29/56 (52%)  32/55 (58%)  35/56 (63%)  32/56 (57%) | 18/56 (32%)  23/56 (41%)  20/56 (36%)  24/56 (43%) |
|ADJUSTED (b)           |  85.4%        85.4%        85.3%        85.6%      |  45.6%        62.8%        55.6%        57.8%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     1/8 (13%)    0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  7/11 (64%)   8/13 (62%)   4/9 (44%)   12/17 (71%) |  5/23 (22%)   9/21 (43%)  11/26 (42%)  12/29 (41%) |
|FIRST INCIDENCE (DAYS) |   418          530          442          547       |   331          328          534          427       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.214N     P=0.486      P=0.142      P=0.231N   |  P=0.513      P=0.212      P=0.513      P=0.416    |
|INCIDENTAL TUMOR       |  P=0.447      P=0.326      P=0.152      P=0.549    |  P=0.141      P=0.198      P=0.367      P=0.077    |
|LOGISTIC REGRESSION    |  P=0.498      P=0.310      P=0.146      P=0.562N   |  P=0.267      P=0.234      P=0.445      P=0.200    |
|COCHRAN-ARMITAGE       |  P=0.338                                           |  P=0.195                                           |
|FISHER EXACT           |               P=0.313      P=0.170      P=0.352    |               P=0.216      P=0.421      P=0.165    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  21
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/56 (5%)    5/55 (9%)    2/56 (4%)    1/56 (2%)  |  0/56 (0%)    0/56 (0%)    0/56 (0%)    0/56 (0%)  |
|ADJUSTED (b)           |   7.4%        26.8%        15.3%         5.9%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |  0/8 (0%)     0/8 (0%)     0/8 (0%)     0/8 (0%)   |
|TERMINAL (d)           |  0/11 (0%)    2/13 (15%)   1/9 (11%)    1/17 (6%)  |  0/23 (0%)    0/21 (0%)    0/26 (0%)    0/29 (0%)  |
|FIRST INCIDENCE (DAYS) |   492          639          673          733 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.087N     P=0.384      P=0.545N     P=0.250N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.135N     P=0.308      P=0.508N     P=0.494N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.111N     P=0.349      P=0.498N     P=0.342N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.135N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.348      P=0.500N     P=0.309N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 53/56 (95%)  53/55 (96%)  53/56 (95%)  55/56 (98%) | 41/56 (73%)  40/56 (71%)  43/56 (77%)  43/56 (77%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      | 100.0%        92.8%        91.2%        93.2%      |
|INTERIM SACRIFICE 1 (c)|  8/8 (100%)   8/8 (100%)   8/8 (100%)   8/8 (100%) |  3/8 (38%)    1/8 (13%)    5/8 (63%)    5/8 (63%)  |
|TERMINAL (d)           | 11/11 (100%) 13/13 (100%)  9/9 (100%)  17/17 (100%)| 23/23 (100%) 18/21 (86%)  22/26 (85%)  26/29 (90%) |
|FIRST INCIDENCE (DAYS) |   394          331          371          456 (I)   |   331          457 (I)      457 (I)      394       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.101N     P=0.411N     P=0.329      P=0.105N   |  P=0.176N     P=0.476      P=0.504N     P=0.218N   |
|INCIDENTAL TUMOR       |  P=0.480      P=0.466      P=0.668N     P=0.511    |  P=0.452N     P=0.298N     P=0.588N     P=0.391N   |
|LOGISTIC REGRESSION    |  P=0.349      P=0.508      P=0.629      P=0.418    |  P=0.510N     P=0.218N     P=0.564      P=0.440N   |
|COCHRAN-ARMITAGE       |  P=0.262                                           |  P=0.311                                           |
|FISHER EXACT           |               P=0.509      P=0.661N     P=0.309    |               P=0.500N     P=0.414      P=0.414    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  22
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      100 PPM      200 PPM      400 PPM   |   CONTROL      100 PPM      200 PPM      400 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 36/56 (64%)  36/55 (65%)  38/56 (68%)  34/56 (61%) | 29/56 (52%)  29/56 (52%)  23/56 (41%)  28/56 (50%) |
|ADJUSTED (b)           |  88.6%        89.7%        86.7%        86.5%      |  67.3%        74.4%        60.1%        64.4%      |
|INTERIM SACRIFICE 1 (c)|  0/8 (0%)     1/8 (13%)    0/8 (0%)     0/8 (0%)   |  0/8 (0%)     1/8 (13%)    0/8 (0%)     1/8 (13%)  |
|TERMINAL (d)           |  7/11 (64%)   9/13 (69%)   4/9 (44%)   12/17 (71%) | 10/23 (43%)  12/21 (57%)  12/26 (46%)  14/29 (48%) |
|FIRST INCIDENCE (DAYS) |   418          456 (I)      371          485       |   310          328          292          427       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.078N     P=0.453N     P=0.293      P=0.076N   |  P=0.142N     P=0.485      P=0.155N     P=0.228N   |
|INCIDENTAL TUMOR       |  P=0.301N     P=0.487      P=0.427      P=0.414N   |  P=0.525N     P=0.579      P=0.228N     P=0.535    |
|LOGISTIC REGRESSION    |  P=0.212N     P=0.581      P=0.413      P=0.227N   |  P=0.309N     P=0.523N     P=0.157N     P=0.419N   |
|COCHRAN-ARMITAGE       |  P=0.371N                                          |  P=0.402N                                          |
|FISHER EXACT           |               P=0.528      P=0.421      P=0.423N   |               P=0.575N     P=0.172N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 56/56 (100%) 55/55 (100%) 56/56 (100%) 56/56 (100%)| 50/56 (89%)  48/56 (86%)  50/56 (89%)  51/56 (91%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      | 100.0%        97.9%        94.3%        98.1%      |
|INTERIM SACRIFICE 1 (c)|  8/8 (100%)   8/8 (100%)   8/8 (100%)   8/8 (100%) |  3/8 (38%)    2/8 (25%)    5/8 (63%)    5/8 (63%)  |
|TERMINAL (d)           | 11/11 (100%) 13/13 (100%)  9/9 (100%)  17/17 (100%)| 23/23 (100%) 20/21 (95%)  23/26 (88%)  28/29 (97%) |
|FIRST INCIDENCE (DAYS) |   394          331          371          456 (I)   |   310          328          292          394       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.071N     P=0.373N     P=0.333      P=0.069N   |  P=0.133N     P=0.543      P=0.383N     P=0.163N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.351      P=0.276N     P=0.583N     P=0.638    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.516N     P=0.116N     P=0.480N     P=0.407N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.347                                           |
|FISHER EXACT           |               P=1.000N     P=1.000N     P=1.000N   |               P=0.388N     P=0.619N     P=0.500    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05133 TEST: 03                                                 PAGE  23
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ACETONITRILE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
                                                                           
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   456
          Female interim sacrifices(days): 457
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.