National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2932

TDMS Study 05133-03 Pathology Tables

NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11




       Facility:  Battelle Northwest

       Chemical CAS #:  75-05-8

       Lock Date:  05/15/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 3| 4| 1| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 2| 5| 3| 3| 3| 5| 2| 3| 3| 3| 2| 2| 3| 5| 2| 7| 5| 0| 3| 9| 2| 6| 3| 3|             
                                           | 6| 7| 7| 4| 4| 4| 7| 1| 4| 4| 4| 5| 1| 4| 7| 3| 7| 7| 5| 4| 7| 9| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                  X           X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |          X                                                        X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X  X  X  X  X  X  X  X  X  X  X  X  X           X     X     X  X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  4                                       |             
      Hepatodiaphragmatic Nodule           | X        X                                                               |             
      Infarct                              |                                                                          |             
      Vacuolization Cytoplasmic            |    4     3                                                     3         |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Hyperplasia              |          4                 2                                   4         |             
      Hepatocyte, Necrosis                 |                                                                          |             
      Portal, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +        +                       +                        |             
      Hemorrhage                           |                                                                          |             
      Fat, Inflammation, Granulomatous     |                                                                          |             
      Fat, Necrosis                        |    4           4        4                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2              1  1  2                 1                 2  2      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |          +                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Mineralization                 |                         3                                                |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                         2                                                |             
      Thrombosis                           |                                                                          |             
      Endocardium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 3| 4| 1| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 2| 5| 3| 3| 3| 5| 2| 3| 3| 3| 2| 2| 3| 5| 2| 7| 5| 0| 3| 9| 2| 6| 3| 3|             
                                           | 6| 7| 7| 4| 4| 4| 7| 1| 4| 4| 4| 5| 1| 4| 7| 3| 7| 7| 5| 4| 7| 9| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            | 2           2                 1                                         3|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2              4        3                       2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                X        X  X        X           X|             
      Pars Distalis, Cyst                  |          4                                                               |             
      Pars Distalis, Hyperplasia           |                3              3        3                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       1                                                                  |             
      C-Cell, Hyperplasia                  |          1                 1  4     1  3     1           3  2  1     2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             3              3  3        3        3                    3   |             
      Hyperplasia                          |             3                 3                                          |             
      Inflammation, Suppurative            |             3                 3                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                                                               |             
      Thrombosis                           |                      X                                                   |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                            +                 +      |             
      Lumbar, Pigmentation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +   |             
      Hemorrhage                           |                      4                                                   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 3| 4| 1| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 2| 5| 3| 3| 3| 5| 2| 3| 3| 3| 2| 2| 3| 5| 2| 7| 5| 0| 3| 9| 2| 6| 3| 3|             
                                           | 6| 7| 7| 4| 4| 4| 7| 1| 4| 4| 4| 5| 1| 4| 7| 3| 7| 7| 5| 4| 7| 9| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       3     3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                         4                             4                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      4                                   2              2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   3      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Re Cell                 |                                  4                                       |             
      Necrosis                             |    4                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Fracture                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2              1                                 |             
      Hydrocephalus                        |                         2                                                |             
      Necrosis                             |                                                          2               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    2  2           2        2  2     2                                    |             
      Hyperplasia                          |                      2        2                                          |             
      Inflammation, Suppurative            |    2  1           2        2                                             |             
      Metaplasia, Squamous                 |                      2     2  3     2                                    |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1     1     1  1|             
      Infiltration Cellular, Histiocyte    |          2                 1     1                 1                     |             
      Alveolar Epithelium, Hyperplasia     |             1           1                                                |             
      Alveolus, Fibrosis                   |          1                                                               |             
      Alveolus, Inflammation, Chronic      |             1                                               1            |             
      Alveolus, Inflammation, Suppurative  |          2                                                               |             
      Pleura, Fibrosis                     |                                        1           1     1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 3| 4| 1| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 0| 2| 5| 3| 3| 3| 5| 2| 3| 3| 3| 2| 2| 3| 5| 2| 7| 5| 0| 3| 9| 2| 6| 3| 3|             
                                           | 6| 7| 7| 4| 4| 4| 7| 1| 4| 4| 4| 5| 1| 4| 7| 3| 7| 7| 5| 4| 7| 9| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |                            2                                         2   |             
      Inflammation, Chronic                |                            4                                             |             
      Inflammation, Suppurative            |                                                                          |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |                            2                                         2   |             
      Respiratory Epithelium, Hyperplasia  |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         3|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2     1  2  1  1     1  2  3  2     1  1           1     2  2  4  1  2  1|             
      Cortex, Necrosis                     |                               2                                4        2|             
      Renal Tubule, Mineralization         | 2  1  2  2  1        2  1  2  2     2  1  1  1  1  1  1  1  1  2     1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 3| 7| 3| 7| 7| 7| 3| 4| 7| 7| 7| 4| 6| 7| 5| 6| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 1| 3| 3| 3| 3| 3| 6| 5| 1| 0| 3| 5| 6| 3| 3| 2| 3| 2| 8| 7|             
                                           | 4| 7| 7| 7| 4| 0| 4| 1| 4| 4| 4| 0| 7| 4| 2| 4| 7| 2| 4| 0| 5| 4| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X     X     X  X  X     X        X        X     X  X  X  X   |             
      Clear Cell Focus                     |                         X                       X                        |             
      Degeneration, Cystic                 |                                                                         1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X        X        X              X        X               |             
      Infarct                              |                                                          4               |             
      Vacuolization Cytoplasmic            |             3                    4     3     1     4     4              2|             
      Bile Duct, Hyperplasia               |                                                          3               |             
      Hepatocyte, Hyperplasia              |             3                          3                                 |             
      Hepatocyte, Necrosis                 |                                              2                           |             
      Portal, Fibrosis                     |                                                          4               |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +           +        +                       +  +            |             
      Hemorrhage                           |                         4                                                |             
      Fat, Inflammation, Granulomatous     |             3                                                            |             
      Fat, Necrosis                        |       3     3                                            2  4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2                                                  1     1  2     1|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Mineralization                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  2                       2               |             
      Hyperplasia, Squamous                |                                  2                       2           1   |             
      Inflammation, Suppurative            |                                  2                       2               |             
      Ulcer                                |                                  4                       4               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                              2                           |             
      Thrombosis                           |                                                          X               |             
      Endocardium, Hyperplasia             |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 3| 7| 3| 7| 7| 7| 3| 4| 7| 7| 7| 4| 6| 7| 5| 6| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 1| 3| 3| 3| 3| 3| 6| 5| 1| 0| 3| 5| 6| 3| 3| 2| 3| 2| 8| 7|             
                                           | 4| 7| 7| 7| 4| 0| 4| 1| 4| 4| 4| 0| 7| 4| 2| 4| 7| 2| 4| 0| 5| 4| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                   2      |             
      Vacuolization Cytoplasmic            |                                                          3        3      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                  X        X            |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 3                          4     3                 2              3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      C-Cell, Hyperplasia                  | 2           2     2     1  1                 1        1  1     1  1     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +|             
      Ectasia                              | 3     3        3  3                                               3      |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            | 3                          3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                          X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                       +                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                4                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +     +                 +               |             
      Lumbar, Pigmentation                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hemorrhage                           |                                                    3                     |             
      Inflammation, Suppurative            |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 3| 7| 3| 7| 7| 7| 3| 4| 7| 7| 7| 4| 6| 7| 5| 6| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 1| 3| 3| 3| 3| 3| 6| 5| 1| 0| 3| 5| 6| 3| 3| 2| 3| 2| 8| 7|             
                                           | 4| 7| 7| 7| 4| 0| 4| 1| 4| 4| 4| 0| 7| 4| 2| 4| 7| 2| 4| 0| 5| 4| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       3                       2           2        3           2     2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                  4                                       |             
      Hyperplasia, Re Cell                 |                4                                                         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Fracture                   |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      4                                   1               |             
      Hydrocephalus                        |                               2           2                              |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
      Hemorrhage                           |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                  2                                       |             
      Hyperplasia                          |                         2                                                |             
      Inflammation, Suppurative            |                                  2                                       |             
      Metaplasia, Squamous                 | 2                       2                                                |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1  1  1     1  1     1  1  1     1     1     1     1  1  1  1     1   |             
      Infiltration Cellular, Histiocyte    |             2     1                       1  1           2     2         |             
      Alveolar Epithelium, Hyperplasia     |                                                          1               |             
      Alveolus, Fibrosis                   |                                                                   1      |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
      Alveolus, Inflammation, Suppurative  | 1                                                                        |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 3| 7| 3| 7| 7| 7| 3| 4| 7| 7| 7| 4| 6| 7| 5| 6| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 5| 2| 5| 3| 1| 3| 3| 3| 3| 3| 6| 5| 1| 0| 3| 5| 6| 3| 3| 2| 3| 2| 8| 7|             
                                           | 4| 7| 7| 7| 4| 0| 4| 1| 4| 4| 4| 0| 7| 4| 2| 4| 7| 2| 4| 0| 5| 4| 1| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                           2                              |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |                                           2                              |             
      Respiratory Epithelium, Hyperplasia  |                                           1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +  +           +                     |             
      Cataract                             |                                                                          |             
      Hemorrhage                           |                                     3  3                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                 +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2     1     2     1     2  2  2        1  1  2  1  2  2     1  2  1      |             
      Cortex, Necrosis                     |                                              3                          3|             
      Renal Tubule, Mineralization         | 2     1     1  2  1  1  2     1     2  1     1  1     1  1  1  1     2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6|                                                        |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3|                                                        |            |
                                           | 4| 4| 4| 4| 7| 7|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    CONTROL                                | 0| 0| 0| 1| 1| 1|                                                        |      L     |
                                           | 7| 8| 9| 0| 1| 2|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  55        |
      Lumen, Parasite Metazoan             |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  55        |
      Lumen, Parasite Metazoan             |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  56        |
      Basophilic Focus                     | X  X  X  X  X                                                            |     40     |
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      7     |
      Infarct                              |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                1                                                         |     11  2.9|
      Bile Duct, Hyperplasia               |                3                                                         |      2  3.0|
      Hepatocyte, Hyperplasia              |    3           3                                                         |      7  3.1|
      Hepatocyte, Necrosis                 |                                                                          |      1  2.0|
      Portal, Fibrosis                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  10        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      7  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  56        |
      Acinus, Atrophy                      |    2  1     1                                                            |     15  1.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  56        |
      Duct, Mineralization                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  56        |
      Edema                                |                                                                          |      2  2.0|
      Hyperplasia, Squamous                |                                                                          |      3  1.7|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  55        |
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6|                                                        |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3|                                                        |            |
                                           | 4| 4| 4| 4| 7| 7|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    CONTROL                                | 0| 0| 0| 1| 1| 1|                                                        |      L     |
                                           | 7| 8| 9| 0| 1| 2|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  56        |
      Cardiomyopathy                       |                                                                          |      2  2.0|
      Thrombosis                           |                                                                          |      1     |
      Endocardium, Hyperplasia             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia                          |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +                                                         |  52        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  56        |
      Cyst                                 | X  X     X     X                                                         |     13     |
      Pars Distalis, Cyst                  |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |          3                                                               |      9  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  56        |
      Dilatation                           |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |    1     1  1  2                                                         |     26  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +                                                         |  54        |
      Ectasia                              |                                                                          |     11  3.0|
      Hyperplasia                          |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  56        |
      Cyst                                 |       X                                                                  |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Endometrium, Hyperplasia             | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6|                                                        |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3|                                                        |            |
                                           | 4| 4| 4| 4| 7| 7|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    CONTROL                                | 0| 0| 0| 1| 1| 1|                                                        |      L     |
                                           | 7| 8| 9| 0| 1| 2|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia, Re Cell                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   7        |
      Lumbar, Pigmentation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +                                                         |  49        |
      Hemorrhage                           |    2     3                                                               |      4  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  54        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |       2  2                                                               |     11  2.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  56        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Re Cell                 |                                                                          |      2  4.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  56        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  55        |
      Vertebra, Fracture                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      4  2.0|
      Hydrocephalus                        |             2                                                            |      4  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6|                                                        |            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3|                                                        |            |
                                           | 4| 4| 4| 4| 7| 7|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    CONTROL                                | 0| 0| 0| 1| 1| 1|                                                        |      L     |
                                           | 7| 8| 9| 0| 1| 2|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  55        |
      Foreign Body                         |    2                                                                     |      8  2.0|
      Hyperplasia                          | 1  2                                                                     |      5  1.8|
      Inflammation, Suppurative            |                                                                          |      5  1.8|
      Metaplasia, Squamous                 |    2                                                                     |      7  2.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           | 1  1  1  1                                                               |     43  1.0|
      Infiltration Cellular, Histiocyte    |             1                                                            |     11  1.4|
      Alveolar Epithelium, Hyperplasia     |    1     2  1                                                            |      6  1.2|
      Alveolus, Fibrosis                   |                                                                          |      2  1.0|
      Alveolus, Inflammation, Chronic      |    2                                                                     |      3  1.3|
      Alveolus, Inflammation, Suppurative  |                                                                          |      2  1.5|
      Pleura, Fibrosis                     |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  55        |
      Foreign Body                         |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hypertrophy                     |                                                                          |      3  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Cataract                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  56        |
      Nephropathy, Chronic                 | 2  2  1  1  1  1                                                         |     40  1.6|
      Cortex, Necrosis                     |                                                                          |      5  2.8|
      Renal Tubule, Mineralization         | 2  1     2  1  1                                                         |     44  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 4| 7| 4| 3| 6| 7| 7| 6| 6| 7| 7| 4| 6| 7| 4|             
                             DAY ON TEST   | 1| 3| 0| 1| 3| 5| 3| 6| 1| 3| 5| 3| 5| 2| 6| 3| 3| 0| 9| 0| 3| 5| 9| 3| 5|             
                                           | 3| 5| 7| 7| 5| 7| 5| 5| 9| 7| 7| 5| 7| 8| 5| 5| 5| 0| 3| 6| 5| 7| 8| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     | X  X  X     X  X  X  X  X     X  X  X     X     X        X  X  X  X     X|             
      Clear Cell Focus                     |                                                                          |             
      Granuloma, Multifocal                |                3                                                     3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Vacuolization Cytoplasmic            |       4  1              2  4                          4  1        3      |             
      Hepatocyte, Degeneration, Cystic     |                                                             2            |             
      Hepatocyte, Hyperplasia              |       3                          4                    4           3      |             
      Serosa, Cyst                         |                                                                          |             
      Serosa, Hemorrhage                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +        +     +                             +                        |             
      Hemorrhage                           | 4                                                                        |             
      Artery, Inflammation                 |                   3                                                      |             
      Fat, Inflammation, Granulomatous     |             3     3                             3                        |             
      Fat, Necrosis                        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    1  1           2  2     1  1  2     2           1     1     1        2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                            2                                             |             
      Hyperplasia, Squamous                |                            2                                      2      |             
      Inflammation, Suppurative            |                                                                   2      |             
      Ulcer                                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                2         |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 4| 7| 4| 3| 6| 7| 7| 6| 6| 7| 7| 4| 6| 7| 4|             
                             DAY ON TEST   | 1| 3| 0| 1| 3| 5| 3| 6| 1| 3| 5| 3| 5| 2| 6| 3| 3| 0| 9| 0| 3| 5| 9| 3| 5|             
                                           | 3| 5| 7| 7| 5| 7| 5| 5| 9| 7| 7| 5| 7| 8| 5| 5| 5| 0| 3| 6| 5| 7| 8| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |             2        2  4                                   3            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         4        3                          2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                       X           X     X     X        X     X     X   |             
      Pars Distalis, Cyst                  |                                                       4                  |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                               3                          3  3            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1  1  1  1     2     1  1     1           1  3     1  1  4  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Ectasia                              | 3                                                                    3   |             
      Hyperplasia                          | 3  3                                      3                              |             
      Inflammation, Suppurative            |                                           3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X           X            |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Endometrium, Hyperplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +                           |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |          4                                                               |             
      Myelofibrosis                        |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +              +                             +                  |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Renal, Hemorrhage                    |          4                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  M  +  M  M  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 4| 7| 4| 3| 6| 7| 7| 6| 6| 7| 7| 4| 6| 7| 4|             
                             DAY ON TEST   | 1| 3| 0| 1| 3| 5| 3| 6| 1| 3| 5| 3| 5| 2| 6| 3| 3| 0| 9| 0| 3| 5| 9| 3| 5|             
                                           | 3| 5| 7| 7| 5| 7| 5| 5| 9| 7| 7| 5| 7| 8| 5| 5| 5| 0| 3| 6| 5| 7| 8| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                              3                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2  3                       3  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Re Cell                 |          4                                                               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                      X                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Suppurative            |             3                    3                                       |             
      Ulcer                                |             4                    4                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        4                                 |             
      Hydrocephalus                        |             2                                                     2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      2                                                   |             
      Hyperplasia                          |                      2                                                   |             
      Metaplasia, Squamous                 |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1     1     1  1           1  1  1  1  1  1  1        1  1  1  1  1  1|             
      Infiltration Cellular, Histiocyte    |                      2  2                                2  2            |             
      Alveolar Epithelium, Hyperplasia     |                         2                                2               |             
      Alveolus, Fibrosis                   |                         3                                                |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    2        2        2                                            2      |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 4| 7| 4| 3| 6| 7| 7| 6| 6| 7| 7| 4| 6| 7| 4|             
                             DAY ON TEST   | 1| 3| 0| 1| 3| 5| 3| 6| 1| 3| 5| 3| 5| 2| 6| 3| 3| 0| 9| 0| 3| 5| 9| 3| 5|             
                                           | 3| 5| 7| 7| 5| 7| 5| 5| 9| 7| 7| 5| 7| 8| 5| 5| 5| 0| 3| 6| 5| 7| 8| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |             2                                                            |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |             2           3                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                           4              3               |             
      Respiratory Epithelium, Hyperplasia  |             3                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                 4                        |             
      Nephropathy, Chronic                 | 2  1  1     2     2     1        2           3  2  1  1     2     2  1   |             
      Cortex, Necrosis                     |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                              3                           |             
      Renal Tubule, Inflammation,          |                                                                          |             
          Suppurative                      |                                              3                           |             
      Renal Tubule, Mineralization         | 1  1  1  1  2     2  2     1     1        1  3  1  1  1  1  1     2     1|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                       4                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 7| 6| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 3| 8| 3| 3| 1| 3| 7| 2| 2| 3| 5| 3| 3| 2| 1| 0| 9| 5| 3| 3|             
                                           | 3| 1| 5| 5| 5| 5| 8| 5| 5| 4| 5| 1| 3| 1| 5| 7| 5| 5| 1| 3| 3| 3| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4                                                               |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X           X  X  X     X  X     X        X  X  X|             
      Clear Cell Focus                     |                               X                                          |             
      Granuloma, Multifocal                |                   3                          3                           |             
      Hematopoietic Cell Proliferation     |                                                          4               |             
      Hepatodiaphragmatic Nodule           |             X                 X              X                           |             
      Vacuolization Cytoplasmic            |                            4     3  2                       4  3         |             
      Hepatocyte, Degeneration, Cystic     |                                                                          |             
      Hepatocyte, Hyperplasia              |                      3           4                       3     3         |             
      Serosa, Cyst                         |                                                                          |             
      Serosa, Hemorrhage                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                            +     +         |             
      Hemorrhage                           |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Fat, Inflammation, Granulomatous     |             3                                                  3         |             
      Fat, Necrosis                        |                                                                3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          1           1  1           1  2           2                 1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                   3                                            2         |             
      Hyperplasia, Squamous                |                   1        3                                3  2         |             
      Inflammation, Suppurative            |                   2        3                                3            |             
      Ulcer                                |                            4                                4            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Thrombosis                           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 7| 6| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 3| 8| 3| 3| 1| 3| 7| 2| 2| 3| 5| 3| 3| 2| 1| 0| 9| 5| 3| 3|             
                                           | 3| 1| 5| 5| 5| 5| 8| 5| 5| 4| 5| 1| 3| 1| 5| 7| 5| 5| 1| 3| 3| 3| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     3                                    |             
      Vacuolization Cytoplasmic            |       3              2                             1           2     2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                2  2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         X  X           X        X  X           X     X  X|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                        4                                 |             
      Pars Distalis, Hyperplasia           |       3                                                           3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1     1  1  1  2        1  3  1  1  1  1     2     2  2  1  2     1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Ectasia                              |       3           3                                                      |             
      Hyperplasia                          |                                     3                                    |             
      Inflammation, Suppurative            |       3                             3                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
      Inflammation, Granulomatous          |                3                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Endometrium, Hyperplasia     |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                                                          |             
      Myelofibrosis                        |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                +           +                           |             
      Pancreatic, Hemorrhage               |                                              2                           |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hemorrhage                           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 7| 6| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 3| 8| 3| 3| 1| 3| 7| 2| 2| 3| 5| 3| 3| 2| 1| 0| 9| 5| 3| 3|             
                                           | 3| 1| 5| 5| 5| 5| 8| 5| 5| 4| 5| 1| 3| 1| 5| 7| 5| 5| 1| 3| 3| 3| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |             3                                1                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Hemorrhage                           |                                              2  3                       1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      3                    3                              |             
      Hyperplasia, Re Cell                 |                                                          4               |             
      Necrosis                             |                                                                3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       3                                                                  |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1  1                       4                                       |             
      Hydrocephalus                        |                                     2  2              2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                        2                                 |             
      Hyperplasia                          |                                                                          |             
      Metaplasia, Squamous                 |       2        2                 1                                       |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1  1  1  1        1        1     1  1  1  1  1  1              1  1   |             
      Infiltration Cellular, Histiocyte    | 2              3  1  2  1        1        1     1        2           1  1|             
      Alveolar Epithelium, Hyperplasia     |                2     2                                                  1|             
      Alveolus, Fibrosis                   |                                                                          |             
      Alveolus, Inflammation, Chronic      |                                                 1                        |             
      Pleura, Fibrosis                     |                                  2                       1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 4| 7| 7| 7| 7| 6| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 3| 8| 3| 3| 1| 3| 7| 2| 2| 3| 5| 3| 3| 2| 1| 0| 9| 5| 3| 3|             
                                           | 3| 1| 5| 5| 5| 5| 8| 5| 5| 4| 5| 1| 3| 1| 5| 7| 5| 5| 1| 3| 3| 3| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                       3                  |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy, Chronic                 | 2  1  4  2  2  1     2  3     1  2  2  1  1     2  1  2  1  4  1     2  1|             
      Cortex, Necrosis                     |    2                                                           3         |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Inflammation,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Renal Tubule, Mineralization         | 1  1  3  1  1  2  1  1        1  1  1  1  2     1  1  2  1  1  1     1   |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 7| 0| 5| 3| 7| 1|                                                        |            |
                                           | 9| 6| 7| 5| 8| 8|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    100 PPM                                | 1| 2| 2| 2| 2| 2|                                                        |      L     |
                                           | 9| 0| 1| 2| 3| 4|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  55        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  56        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  54        |
      Lumen, Parasite Metazoan             |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  55        |
      Inflammation, Granulomatous          |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  55        |
      Inflammation, Granulomatous          |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  56        |
      Atrophy                              |                                                                          |      1  4.0|
      Basophilic Focus                     |    X  X  X  X  X                                                         |     41     |
      Clear Cell Focus                     |                X                                                         |      2     |
      Granuloma, Multifocal                |                                                                          |      4  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Vacuolization Cytoplasmic            | 3              2                                                         |     14  2.9|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      1  2.0|
      Hepatocyte, Hyperplasia              | 4                                                                        |      9  3.4|
      Serosa, Cyst                         |                X                                                         |      1     |
      Serosa, Hemorrhage                   | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   9        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Fat, Inflammation, Granulomatous     |    3                                                                     |      6  3.0|
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  56        |
      Acinus, Atrophy                      |          2  2  1                                                         |     22  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  54        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  56        |
      Edema                                |                                                                          |      3  2.3|
      Hyperplasia, Squamous                |                                                                          |      6  2.2|
      Inflammation, Suppurative            |                3                                                         |      5  2.6|
      Ulcer                                |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 7| 0| 5| 3| 7| 1|                                                        |            |
                                           | 9| 6| 7| 5| 8| 8|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    100 PPM                                | 1| 2| 2| 2| 2| 2|                                                        |      L     |
                                           | 9| 0| 1| 2| 3| 4|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  56        |
      Cardiomyopathy                       |       2                                                                  |      2  2.0|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia                          | 4                                                                        |      2  3.5|
      Vacuolization Cytoplasmic            |          2     1                                                         |     11  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  55        |
      Hyperplasia                          |                                                                          |      6  2.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +                                                         |  52        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  56        |
      Cyst                                 | X                                                                        |     17     |
      Pars Distalis, Cyst                  |                                                                          |      1  4.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  56        |
      C-Cell, Hyperplasia                  | 1  1     1     1                                                         |     39  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +                                                         |  50        |
      Ectasia                              |                                                                          |      4  3.0|
      Hyperplasia                          |                                                                          |      4  3.0|
      Inflammation, Suppurative            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  56        |
      Cyst                                 |                                                                          |      3     |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  56        |
      Cervix, Endometrium, Hyperplasia     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 7| 0| 5| 3| 7| 1|                                                        |            |
                                           | 9| 6| 7| 5| 8| 8|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    100 PPM                                | 1| 2| 2| 2| 2| 2|                                                        |      L     |
                                           | 9| 0| 1| 2| 3| 4|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Re Cell                 |    4        4                                                            |      3  4.0|
      Myelofibrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +                                                         |  44        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  55        |
      Hemorrhage                           |                                                                          |      3  2.3|
      Hyperplasia, Lymphoid                |       4                                                                  |      1  4.0|
      Inflammation, Granulomatous          |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  53        |
      Hemorrhage                           |                                                                          |      7  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  56        |
      Fibrosis                             |                                                                          |      2  3.0|
      Hyperplasia, Re Cell                 |             4                                                            |      3  4.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  56        |
      Galactocele                          |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  56        |
      Acanthosis                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                3                                                         |      5  2.6|
      Hydrocephalus                        |                2                                                         |      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 7| 0| 5| 3| 7| 1|                                                        |            |
                                           | 9| 6| 7| 5| 8| 8|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    100 PPM                                | 1| 2| 2| 2| 2| 2|                                                        |      L     |
                                           | 9| 0| 1| 2| 3| 4|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  56        |
      Foreign Body                         |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |          2                                                               |      5  1.8|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           | 1  1  1     1                                                            |     37  1.0|
      Infiltration Cellular, Histiocyte    |       1  1                                                               |     17  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      5  1.8|
      Alveolus, Fibrosis                   |                                                                          |      1  3.0|
      Alveolus, Inflammation, Chronic      |                                                                          |      1  1.0|
      Pleura, Fibrosis                     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  55        |
      Foreign Body                         |          2                                                               |      5  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |          2                                                               |      2  2.0|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hypertrophy                     |                                                                          |      2  2.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      3  3.3|
      Respiratory Epithelium, Hyperplasia  |          1                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   2        |
      Hemorrhage                           |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  56        |
      Infarct                              |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 2     1        2                                                         |     38  1.7|
      Cortex, Necrosis                     |                                                                          |      2  2.5|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
      Renal Tubule, Inflammation,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Renal Tubule, Mineralization         |       1  2  1  1                                                         |     42  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 7| 0| 5| 3| 7| 1|                                                        |            |
                                           | 9| 6| 7| 5| 8| 8|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    100 PPM                                | 1| 2| 2| 2| 2| 2|                                                        |      L     |
                                           | 9| 0| 1| 2| 3| 4|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  56        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 5| 7| 6| 4| 7| 5| 5| 6| 7| 4| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 3| 9| 3| 2| 5| 3| 6| 5| 5| 3| 5| 3| 7| 5| 3| 3| 3| 3| 6|             
                                           | 5| 5| 7| 3| 9| 5| 5| 7| 5| 5| 7| 5| 6| 5| 1| 5| 7| 5| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinum, Cyst                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |       X  X                                                           X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X        X  X  X  X     X  X  X  X  X     X  X  X  X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                               X                                          |             
      Granuloma, Multifocal                |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X              X           X              X         |             
      Vacuolization Cytoplasmic            |                   2  4           1                          1            |             
      Hepatocyte, Degeneration, Cystic     |                                                                         2|             
      Hepatocyte, Hyperplasia              |          4              3                                                |             
      Hepatocyte, Necrosis                 |                         2                                                |             
      Serosa, Hemorrhage                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                    +     +     +  +   |             
      Hemorrhage                           |                                                                          |             
      Artery, Inflammation                 |                                                             4            |             
      Fat, Inflammation, Granulomatous     |                                  2                                4      |             
      Fat, Necrosis                        |                                  2                    4              4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2  1  1  2        1     2                 2  2  1        1  2  1  1  2   |             
      Artery, Inflammation                 |                                                       3                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Diverticulum                         |    3                                                           3         |             
      Edema                                |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Hyperplasia, Squamous                |                      3                                   2               |             
      Inflammation, Suppurative            |                      2                                                   |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation                  |                                                             4            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 5| 7| 6| 4| 7| 5| 5| 6| 7| 4| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 3| 9| 3| 2| 5| 3| 6| 5| 5| 3| 5| 3| 7| 5| 3| 3| 3| 3| 6|             
                                           | 5| 5| 7| 3| 9| 5| 5| 7| 5| 5| 7| 5| 6| 5| 1| 5| 7| 5| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |                                                                2  2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       4                                                                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X     X           X                 X                 X  X      |             
      Pars Distalis, Hyperplasia           |                      2                                            3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 | X                                                                        |             
      C-Cell, Hyperplasia                  | 1  2  1        1  1     1  3     1        1  2     2  1     4  2     2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        3                 3  3           3|             
      Hyperplasia                          | 3                                                                        |             
      Inflammation, Suppurative            |                               3                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X     X               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Endometrium, Hyperplasia     |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |          4  4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                +           +              +   |             
      Axillary, Hyperplasia, Lymphoid      |                                                                      4   |             
      Iliac, Pigmentation                  |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Hemorrhage                    |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 5| 7| 6| 4| 7| 5| 5| 6| 7| 4| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 3| 9| 3| 2| 5| 3| 6| 5| 5| 3| 5| 3| 7| 5| 3| 3| 3| 3| 6|             
                                           | 5| 5| 7| 3| 9| 5| 5| 7| 5| 5| 7| 5| 6| 5| 1| 5| 7| 5| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        1                       2         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                    3                     |             
      Hemorrhage                           |                                           4                              |             
      Hyperplasia, Re Cell                 |                                                                      4   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Epithelium, Hyperplasia              |                                                                         3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Granulomatous          |                               4                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       2                                2                                 |             
      Hydrocephalus                        |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       2                                                                  |             
      Hyperplasia                          |                               1     2                                    |             
      Inflammation, Suppurative            |       2                       1                                          |             
      Metaplasia, Squamous                 |       2                             2                                    |             
      Mineralization                       |                               1                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    1     1  1  1  1        1  1  1     1     1  1  1     1  1  1  1  1  1|             
      Infiltration Cellular, Histiocyte    | 1     2  2     1     1  1  1                       1  1     1            |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1        3                                                            |             
      Alveolus, Fibrosis                   |    1                                                                     |             
      Pleura, Fibrosis                     |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 5| 7| 6| 4| 7| 5| 5| 6| 7| 4| 7| 6| 4| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 2| 2| 6| 3| 3| 9| 3| 2| 5| 3| 6| 5| 5| 3| 5| 3| 7| 5| 3| 3| 3| 3| 6|             
                                           | 5| 5| 7| 3| 9| 5| 5| 7| 5| 5| 7| 5| 6| 5| 1| 5| 7| 5| 1| 7| 5| 5| 5| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                | 2                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 2                                                                        |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Cataract                             |    3                                                                     |             
      Hemorrhage                           |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  1  2  1     2  3     1  1     2  1  2     2     1  1     2  2  2  1  2|             
      Cortex, Necrosis                     | 2                                   3              3                 2   |             
      Renal Tubule, Mineralization         | 1  1  1  2  1     1  2     1     2  2  2  1  1     1  1  2  1  1  1     2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 5| 7| 4| 4| 6| 7| 4| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 3| 3| 3| 5| 5| 9| 3| 8| 7| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 5| 8| 3| 1|             
                                           | 7| 6| 5| 4| 5| 7| 7| 3| 5| 5| 1| 5| 2| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinum, Cyst                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                        X                             X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X           X     X  X  X  X  X        X  X     X  X     X  X        X   |             
      Clear Cell Focus                     |                                        X                                 |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma, Multifocal                |                            3                 3                           |             
      Hepatodiaphragmatic Nodule           |                                     X  X                 X               |             
      Vacuolization Cytoplasmic            |       3  4                 2                          4        3  4     4|             
      Hepatocyte, Degeneration, Cystic     |                                                                          |             
      Hepatocyte, Hyperplasia              |       2                                               4                  |             
      Hepatocyte, Necrosis                 |    1  1                                                                  |             
      Serosa, Hemorrhage                   | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Hemorrhage                           |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Fat, Inflammation, Granulomatous     |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       1     1  2  1  2           1           2  2  2        2     2  2   |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Edema                                |                                                       4        3  3     3|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Hyperplasia, Squamous                |                                     2                 4        2  4     2|             
      Inflammation, Suppurative            |                                                       3           3     3|             
      Necrosis                             |                                                                         1|             
      Ulcer                                |       2                                               4           4     4|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 5| 7| 4| 4| 6| 7| 4| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 3| 3| 3| 5| 5| 9| 3| 8| 7| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 5| 8| 3| 1|             
                                           | 7| 6| 5| 4| 5| 7| 7| 3| 5| 5| 1| 5| 2| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4                                                                  |             
      Vacuolization Cytoplasmic            |       2                                2                          2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                        2  2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |       2                                                                 2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                          X        X        X              X        X|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       1  1  2        1  3  1     1     1  2     1  1  2  2     1  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             3              3              3                       3  3   |             
      Hyperplasia                          |                                                 3                 3      |             
      Inflammation, Suppurative            |                                           3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Endometrium, Hyperplasia     |                                                       3                  |             
      Endometrium, Hyperplasia             |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                              +        +     +  +        +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Iliac, Pigmentation                  |                                                             2            |             
      Pancreatic, Pigmentation             |                                              3                           |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  M  M  M  +  M  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            3        3        3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 5| 7| 4| 4| 6| 7| 4| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 3| 3| 3| 5| 5| 9| 3| 8| 7| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 5| 8| 3| 1|             
                                           | 7| 6| 5| 4| 5| 7| 7| 3| 5| 5| 1| 5| 2| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                                            |             
      Hyperplasia, Lymphoid                |                                              4                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |       4                                                                  |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Necrosis                             |                                                                4         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                      4                                                   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                1                                                         |             
      Inflammation, Granulomatous          |                                           4                              |             
      Ulcer                                |                2                                                         |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                       1                       2     1  4  1   |             
      Hydrocephalus                        |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             2  2                                                         |             
      Hyperplasia                          |                3                                                         |             
      Inflammation, Suppurative            |                4           1  1  1                                       |             
      Metaplasia, Squamous                 |             2  2              1  2  1                                    |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1        1  1  1     1     1  1  1  1  1  1  1  1     1  1  1     1   |             
      Infiltration Cellular, Histiocyte    | 1                             1        2  1           2                  |             
      Metaplasia, Osseous                  |                                     1                                    |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Fibrosis                   |                                                                          |             
      Pleura, Fibrosis                     |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 5| 7| 4| 4| 6| 7| 4| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 3| 3| 3| 5| 5| 9| 3| 8| 7| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 5| 8| 3| 1|             
                                           | 7| 6| 5| 4| 5| 7| 7| 3| 5| 5| 1| 5| 2| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                           2                              |             
      Hemorrhage                           |                                                                   3      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                               2           3                              |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |                                           2                              |             
      Respiratory Epithelium, Hyperplasia  |                                           3                              |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                               3                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +           +               |             
      Cataract                             |                                                          3               |             
      Hemorrhage                           |                                                          3               |             
      Retina, Atrophy                      |                                                          3               |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |       4     2  1     1  1        4     3  1     1  1     2        1  1  2|             
      Cortex, Necrosis                     |       2                                                                  |             
      Renal Tubule, Mineralization         | 1  1  1  1  1        1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  2  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 5| 7|                                                        |            |
                             DAY ON TEST   | 3| 3| 5| 6| 8| 3|                                                        |            |
                                           | 5| 5| 7| 5| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    200 PPM                                | 3| 3| 3| 3| 3| 3|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  56        |
      Mediastinum, Cyst                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  56        |
      Lumen, Parasite Metazoan             |    X                                                                     |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  55        |
      Lumen, Parasite Metazoan             |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  54        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  56        |
      Basophilic Focus                     | X  X     X     X                                                         |     38     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Granuloma, Multifocal                |                                                                          |      2  3.0|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      8     |
      Vacuolization Cytoplasmic            |             3                                                            |     12  2.9|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      1  2.0|
      Hepatocyte, Hyperplasia              |                                                                          |      4  3.3|
      Hepatocyte, Necrosis                 |                                                                          |      3  1.3|
      Serosa, Hemorrhage                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +           +                                                            |   8        |
      Hemorrhage                           | 4           4                                                            |      2  4.0|
      Artery, Inflammation                 |                                                                          |      1  4.0|
      Fat, Inflammation, Granulomatous     | 3           2                                                            |      4  2.8|
      Fat, Necrosis                        | 3                                                                        |      4  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  56        |
      Acinus, Atrophy                      |    1  1  2                                                               |     29  1.6|
      Artery, Inflammation                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  55        |
      Diverticulum                         |                                                                          |      2  3.0|
      Edema                                |             3                                                            |      5  3.2|
      Hyperplasia, Basal Cell              | 1                                                                        |      1  1.0|
      Hyperplasia, Squamous                |             2                                                            |      8  2.6|
      Inflammation, Suppurative            |                                                                          |      4  2.8|
      Necrosis                             |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 5| 7|                                                        |            |
                             DAY ON TEST   | 3| 3| 5| 6| 8| 3|                                                        |            |
                                           | 5| 5| 7| 5| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    200 PPM                                | 3| 3| 3| 3| 3| 3|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +                                                         |  56        |
      Aorta, Inflammation                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  56        |
      Cardiomyopathy                       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            | 2           1                                                            |      5  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  55        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hyperplasia                          |          3                                                               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  51        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  55        |
      Cyst                                 |          X     X                                                         |     14     |
      Pars Distalis, Hyperplasia           |                3                                                         |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  56        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  | 1  1           2                                                         |     36  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +                                                         |  55        |
      Ectasia                              |    3                                                                     |     10  3.0|
      Hyperplasia                          |          3                                                               |      4  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  56        |
      Cyst                                 |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  56        |
      Cervix, Endometrium, Hyperplasia     |                                                                          |      1  3.0|
      Endometrium, Hyperplasia             |          3                                                               |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 5| 7|                                                        |            |
                             DAY ON TEST   | 3| 3| 5| 6| 8| 3|                                                        |            |
                                           | 5| 5| 7| 5| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    200 PPM                                | 3| 3| 3| 3| 3| 3|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia, Re Cell                 |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   9        |
      Axillary, Hyperplasia, Lymphoid      |                                                                          |      1  4.0|
      Iliac, Pigmentation                  |                                                                          |      1  2.0|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +                                                         |  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  52        |
      Hyperplasia, Lymphoid                |       3                                                                  |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  53        |
      Hemorrhage                           |                                                                          |      3  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  56        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  4.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +                                                         |  55        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  56        |
      Galactocele                          |          X                                                               |      2  4.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  56        |
      Acanthosis                           |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |      2  4.0|
      Ulcer                                |                                                                          |      1  2.0|
      Subcutaneous Tissue, Hemorrhage      |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      8  1.9|
      Hydrocephalus                        | 2                                                                        |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 5| 7|                                                        |            |
                             DAY ON TEST   | 3| 3| 5| 6| 8| 3|                                                        |            |
                                           | 5| 5| 7| 5| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    200 PPM                                | 3| 3| 3| 3| 3| 3|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  56        |
      Foreign Body                         |       2                                                                  |      4  2.0|
      Hyperplasia                          |                                                                          |      3  2.0|
      Inflammation, Suppurative            |                                                                          |      6  1.7|
      Metaplasia, Squamous                 |                                                                          |      7  1.7|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           | 1  1  1        1                                                         |     40  1.0|
      Infiltration Cellular, Histiocyte    |          3     1                                                         |     17  1.4|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Alveolus, Fibrosis                   |                                                                          |      1  1.0|
      Pleura, Fibrosis                     |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  56        |
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                2                                                         |      3  2.3|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hypertrophy                     |                2                                                         |      2  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  2.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   4        |
      Cataract                             |                                                                          |      2  3.0|
      Hemorrhage                           |       3                                                                  |      2  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  56        |
      Nephropathy, Chronic                 | 3  2     1  1  1                                                         |     38  1.7|
      Cortex, Necrosis                     |                                                                          |      5  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 5| 7|                                                        |            |
                             DAY ON TEST   | 3| 3| 5| 6| 8| 3|                                                        |            |
                                           | 5| 5| 7| 5| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    200 PPM                                | 3| 3| 3| 3| 3| 3|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Mineralization         | 2  2     1  1  1                                                         |     48  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  55        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 4| 7| 6| 7| 6| 7| 6| 6| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 7| 5| 3| 5| 3| 1| 3| 7| 2| 7| 6| 5| 3| 5| 2| 3| 5| 3| 3| 3| 3| 3| 7| 7|             
                                           | 4| 0| 8| 4| 7| 4| 8| 4| 2| 3| 9| 6| 7| 4| 7| 1| 4| 7| 4| 4| 4| 4| 4| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Lumen, Parasite Metazoan             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X     X  X  X        X     X  X     X  X  X  X  X  X  X  X  X        X|             
      Degeneration, Cystic                 |                                                                1         |             
      Granuloma, Multifocal                |                                                                          |             
      Hepatodiaphragmatic Nodule           | X  X              X     X                    X        X                  |             
      Mixed Cell Focus                     |                                                          X               |             
      Vacuolization Cytoplasmic            |                   4        3  1  4           2  2        2     1         |             
      Hepatocyte, Degeneration, Cystic     | 3                                                           1            |             
      Hepatocyte, Hyperplasia              |                   4        4     1              3                       3|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +  +  +                             +  +  +                  |             
      Hemorrhage                           |                                                                          |             
      Fat, Inflammation, Granulomatous     |          4  3  3  3                                3                     |             
      Fat, Necrosis                        |          4  3  3  2                             4     4                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Acinus, Atrophy                      | 1  2     2     2                 2  2  2  2  2           1  2  1         |             
      Artery, Inflammation                 |                                              4                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia, Basal Cell              |    1                                   1                                 |             
      Hyperplasia, Squamous                |                   4        4     3                                       |             
      Inflammation, Suppurative            |                   4        3     3                                       |             
      Ulcer                                |                   4        3     4                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Mineralization                       |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                              3                           |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                              2                           |             
      Thrombosis                           |                                                                          |             
      Endocardium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 4| 7| 6| 7| 6| 7| 6| 6| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 7| 5| 3| 5| 3| 1| 3| 7| 2| 7| 6| 5| 3| 5| 2| 3| 5| 3| 3| 3| 3| 3| 7| 7|             
                                           | 4| 0| 8| 4| 7| 4| 8| 4| 2| 3| 9| 6| 7| 4| 7| 1| 4| 7| 4| 4| 4| 4| 4| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Mineralization                       |                                              2                           |             
      Vacuolization Cytoplasmic            |    2                 3     2  1  3                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                                              3                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Cyst                                 | X                    X           X                    X  X  X           X|             
      Pars Distalis, Cyst                  |                                     4                                    |             
      Pars Distalis, Hyperplasia           |                3                                                        4|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      C-Cell, Hyperplasia                  | 2        1     1     2  4  2     2  1  1     1  2     1  1  1  2  2     4|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       3              3     3     3           3                           |             
      Hyperplasia                          |       3                                                     3            |             
      Inflammation, Suppurative            |                3     3                                      3            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                         X     X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +     +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M|             
      Hemorrhage                           |          3                                               2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       3  3                       2           3        3  2               |             
      Pigmentation                         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +|             
      Developmental Malformation           |                                                                         X|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 4| 7| 6| 7| 6| 7| 6| 6| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 7| 5| 3| 5| 3| 1| 3| 7| 2| 7| 6| 5| 3| 5| 2| 3| 5| 3| 3| 3| 3| 3| 7| 7|             
                                           | 4| 0| 8| 4| 7| 4| 8| 4| 2| 3| 9| 6| 7| 4| 7| 1| 4| 7| 4| 4| 4| 4| 4| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |       3                                                                  |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Necrosis        |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              3                           |             
      Periosteum, Cranium, Hemorrhage      |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |    2                                         2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Foreign Body                         |    2                          2                 2                        |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                 2                        |             
      Metaplasia, Squamous                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hemorrhage                           | 1        1  1  1     1              1  1  1  1  1  1     1  1  1  1      |             
      Infiltration Cellular, Histiocyte    |    1     2     4              1           1     1                 1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Inflammation, Chronic      |                                              1                           |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Foreign Body                         |                                              2                    2      |             
      Hemorrhage                           |                                              3                           |             
      Inflammation, Chronic                |                                                                   2      |             
      Inflammation, Suppurative            |                                                                          |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                   3      |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 4| 7| 6| 7| 6| 7| 6| 6| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 7| 5| 3| 5| 3| 1| 3| 7| 2| 7| 6| 5| 3| 5| 2| 3| 5| 3| 3| 3| 3| 3| 7| 7|             
                                           | 4| 0| 8| 4| 7| 4| 8| 4| 2| 3| 9| 6| 7| 4| 7| 1| 4| 7| 4| 4| 4| 4| 4| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                          +                     |             
      Cataract                             |                                                    3                     |             
      Hemorrhage                           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Nephropathy, Chronic                 | 2  2  2  2        1  2     2  2  1     3     4  2     1  2  2  2  1     2|             
      Cortex, Necrosis                     |                         3                             3                  |             
      Renal Tubule, Mineralization         | 1  1     2     1     1  2  2  2  2  1  1     3     1  2  2     1  1     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 4| 4| 3| 7| 6| 6| 7| 4| 7| 7| 6| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 5| 9| 3| 3| 3| 2| 0| 3| 5| 2| 9| 3| 2| 7| 3| 5| 3| 3| 7| 5| 3| 9| 3|             
                                           | 4| 4| 7| 3| 4| 4| 4| 9| 7| 4| 7| 7| 4| 4| 9| 2| 4| 7| 4| 4| 9| 7| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  I  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                         X        X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               4                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X        X  X        X  X     X     X  X  X  X|             
      Degeneration, Cystic                 |                                                                          |             
      Granuloma, Multifocal                |                                                    3                    3|             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Mixed Cell Focus                     |                                                 X                        |             
      Vacuolization Cytoplasmic            | 1                    1           3           4        4  2  4     2      |             
      Hepatocyte, Degeneration, Cystic     |                                                                         3|             
      Hepatocyte, Hyperplasia              |    4                 4                          4                 3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +                                                         |             
      Hemorrhage                           |                                                                          |             
      Fat, Inflammation, Granulomatous     |          3                                                               |             
      Fat, Necrosis                        |          3     3                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2        1  2     1        2     2           2  2     2  1        2     1|             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Hyperplasia, Squamous                |                                              3        4  3               |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                              3                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                              2                           |             
      Thrombosis                           |                                                       X                  |             
      Endocardium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 4| 4| 3| 7| 6| 6| 7| 4| 7| 7| 6| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 5| 9| 3| 3| 3| 2| 0| 3| 5| 2| 9| 3| 2| 7| 3| 5| 3| 3| 7| 5| 3| 9| 3|             
                                           | 4| 4| 7| 3| 4| 4| 4| 9| 7| 4| 7| 7| 4| 4| 9| 2| 4| 7| 4| 4| 9| 7| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Vacuolization Cytoplasmic            |                            2                                            3|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X     X  X  X  X                    X                  |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                      4                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1     1  1  1  1     2  4           1     1  1     1  1  1     1     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3           3           3  3                    3        3  3            |             
      Hyperplasia                          |                                        3                                 |             
      Inflammation, Suppurative            |             3           3  3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                 X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                     4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                 +           +              +           +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3        2        2                                         2   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                                                 4     3     4            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 4| 4| 3| 7| 6| 6| 7| 4| 7| 7| 6| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 5| 9| 3| 3| 3| 2| 0| 3| 5| 2| 9| 3| 2| 7| 3| 5| 3| 3| 7| 5| 3| 9| 3|             
                                           | 4| 4| 7| 3| 4| 4| 4| 9| 7| 4| 7| 7| 4| 4| 9| 2| 4| 7| 4| 4| 9| 7| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Ulcer                                |                                                                         4|             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Periosteum, Cranium, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              2                       2   |             
      Hydrocephalus                        |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                    2                     |             
      Hyperplasia                          |       1        3                             1              1            |             
      Inflammation, Suppurative            |                3                                            2            |             
      Metaplasia, Squamous                 |                2                             1                           |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1     1     1  1  1     1  1  1  1  1  1     1  1  1           1  1  1  1|             
      Infiltration Cellular, Histiocyte    |                      2  2  1                    1                 1      |             
      Alveolar Epithelium, Hyperplasia     |                      1                                                   |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         2                                                |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                   4      |             
      Inflammation, Suppurative            |    1                    3                                                |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |    3                    3  2                          3                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          3                                                               |             
      Olfactory Epithelium, Metaplasia     |    3                                                                     |             
      Respiratory Epithelium, Hyperplasia  |                         3                                                |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 4| 4| 3| 7| 6| 6| 7| 4| 7| 7| 6| 4| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 5| 9| 3| 3| 3| 2| 0| 3| 5| 2| 9| 3| 2| 7| 3| 5| 3| 3| 7| 5| 3| 9| 3|             
                                           | 4| 4| 7| 3| 4| 4| 4| 9| 7| 4| 7| 7| 4| 4| 9| 2| 4| 7| 4| 4| 9| 7| 4| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +|             
      Epithelium, Hyperplasia              |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +           +            |             
      Cataract                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2     3  1  2  1  1  2  2           3     4  1     1  1        2  1  1|             
      Cortex, Necrosis                     |          1              2              2                                 |             
      Renal Tubule, Mineralization         | 2           1  1  1     2  1  1  1  1  2     1  2     1  2  1  1  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3|                                                        |            |
                                           | 4| 4| 4| 4| 4| 4|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |      A     |
    400 PPM                                | 4| 4| 4| 4| 4| 4|                                                        |      L     |
                                           | 3| 4| 5| 6| 7| 8|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  53        |
      Lumen, Parasite Metazoan             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  53        |
      Lumen, Parasite Metazoan             | X                                                                        |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  54        |
      Angiectasis                          |                                                                          |      1  4.0|
      Basophilic Focus                     | X     X  X  X  X                                                         |     42     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Granuloma, Multifocal                |          2                                                               |      3  2.7|
      Hepatodiaphragmatic Nodule           |          X                                                               |      8     |
      Mixed Cell Focus                     |                                                                          |      2     |
      Vacuolization Cytoplasmic            | 2        3  2  1                                                         |     20  2.4|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      3  2.3|
      Hepatocyte, Hyperplasia              |       2                                                                  |     10  3.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +     +                                                         |  11        |
      Hemorrhage                           |                4                                                         |      1  4.0|
      Fat, Inflammation, Granulomatous     |                3                                                         |      7  3.1|
      Fat, Necrosis                        |          3                                                               |      9  3.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  54        |
      Acinus, Atrophy                      | 2        2     2                                                         |     27  1.7|
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  54        |
      Hyperplasia, Basal Cell              |                                                                          |      2  1.0|
      Hyperplasia, Squamous                |          4                                                               |      7  3.6|
      Inflammation, Suppurative            |                                                                          |      3  3.3|
      Ulcer                                |          4                                                               |      5  3.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  54        |
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +                                                         |  55        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  55        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3|                                                        |            |
                                           | 4| 4| 4| 4| 4| 4|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |      A     |
    400 PPM                                | 4| 4| 4| 4| 4| 4|                                                        |      L     |
                                           | 3| 4| 5| 6| 7| 8|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |                                                                          |      2  2.0|
      Thrombosis                           |                                                                          |      1     |
      Endocardium, Hyperplasia             |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  54        |
      Mineralization                       |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |    3                                                                     |      8  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  55        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  54        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  52        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  53        |
      Cyst                                 | X           X                                                            |     15     |
      Pars Distalis, Cyst                  |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  54        |
      C-Cell, Hyperplasia                  | 1  2  1  1  4  1                                                         |     39  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  +                                                         |  53        |
      Ectasia                              |       3        3                                                         |     14  3.0|
      Hyperplasia                          |                                                                          |      3  3.0|
      Inflammation, Suppurative            |                                                                          |      6  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  55        |
      Cyst                                 |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  55        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  54        |
      Hyperplasia, Re Cell                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +                                                         |  48        |
      Hemorrhage                           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M                                                         |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3|                                                        |            |
                                           | 4| 4| 4| 4| 4| 4|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |      A     |
    400 PPM                                | 4| 4| 4| 4| 4| 4|                                                        |      L     |
                                           | 3| 4| 5| 6| 7| 8|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  55        |
      Hemorrhage                           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +                                                         |  54        |
      Hemorrhage                           |    2                                                                     |     11  2.5|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  53        |
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis                             |                                                                          |      3  3.7|
      Hematopoietic Cell Proliferation     |          2                                                               |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  55        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  56        |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Ulcer                                |             4                                                            |      2  4.0|
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  55        |
      Fibrosis                             |                                                                          |      1  3.0|
      Periosteum, Cranium, Hemorrhage      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  55        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Hydrocephalus                        |       2  2                                                               |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  54        |
      Foreign Body                         |                                                                          |      4  2.0|
      Hyperplasia                          |                                                                          |      4  1.5|
      Inflammation, Suppurative            |                                                                          |      3  2.3|
      Metaplasia, Squamous                 |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  54        |
      Hemorrhage                           | 1  1  1     1  1                                                         |     38  1.0|
      Infiltration Cellular, Histiocyte    |             1                                                            |     13  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3|                                                        |            |
                                           | 4| 4| 4| 4| 4| 4|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |      A     |
    400 PPM                                | 4| 4| 4| 4| 4| 4|                                                        |      L     |
                                           | 3| 4| 5| 6| 7| 8|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Inflammation, Chronic      |                                                                          |      1  1.0|
      Pleura, Fibrosis                     |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  54        |
      Foreign Body                         |                                                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hypertrophy                     |                                                                          |      4  2.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  3.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  3.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  53        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Cataract                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  54        |
      Nephropathy, Chronic                 | 1  1  2  2     1                                                         |     40  1.8|
      Cortex, Necrosis                     |                                                                          |      5  2.2|
      Renal Tubule, Mineralization         | 1  2  2  1  1                                                            |     41  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 4| 3| 5| 7| 6| 6| 6| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 3| 3| 8| 5| 8| 3| 5| 2| 6| 5| 2| 3| 5| 9| 8| 2| 4| 0| 7| 5| 2| 3| 6|             
                                           | 3| 9| 7| 2| 5| 1| 3| 3| 1| 4| 6| 2| 3| 3| 6| 4| 7| 1| 6| 9| 9| 6| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                               X                 X                 X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lumen, Parasite Metazoan             |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lumen, Parasite Metazoan             |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X        X  X     X                 X  X                 X     X  X   |             
      Clear Cell Focus                     |                      X                    X                              |             
      Degeneration, Cystic                 | 1     4        1        1     2           1     1     4              1   |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                         1                                1               |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Inflammation, Chronic                |                                                 2                        |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |          3        3  2        3                          4               |             
      Bile Duct, Hyperplasia               |                                                 3                        |             
      Hepatocyte, Necrosis                 |          1                          2              1     1               |             
      Portal, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +        +           +  +     +               |             
      Hemorrhage                           |                                     4           4                        |             
      Fat, Inflammation, Granulomatous     |                            3                                             |             
      Fat, Necrosis                        |                            3        3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1           1  2  2  1        2  2  2  2        2           1        1  2|             
      Duct, Cyst                           |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Suppurative            |                                                 2                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Aorta, Inflammation                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 4| 3| 5| 7| 6| 6| 6| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 3| 3| 8| 5| 8| 3| 5| 2| 6| 5| 2| 3| 5| 9| 8| 2| 4| 0| 7| 5| 2| 3| 6|             
                                           | 3| 9| 7| 2| 5| 1| 3| 3| 1| 4| 6| 2| 3| 3| 6| 4| 7| 1| 6| 9| 9| 6| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2        2     2                                            2   |             
      Atrium, Thrombosis                   |       X  X  X                    X                       X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                                    1  2  3               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1        4  2        1  3  4     2  3              2  2              2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       X                  |             
      Hemorrhage                           |                                                             4            |             
      Pars Distalis, Hemorrhage            |                                                             4            |             
      Pars Distalis, Hyperplasia           |       3              3                    3                          3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                          2        3                              |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia         | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3     3     3     3        3     3  3                    3           3  3|             
      Hyperplasia                          |                                     3                                    |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |             3     3                                                      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2                 2                       2  2               |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Germinal Epithelium, Atrophy         | 4        4  4  4     4                 4                 4               |             
      Interstitial Cell, Hyperplasia       | 1              2  1     3        2              1     2     2           2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 4| 3| 5| 7| 6| 6| 6| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 3| 3| 8| 5| 8| 3| 5| 2| 6| 5| 2| 3| 5| 9| 8| 2| 4| 0| 7| 5| 2| 3| 6|             
                                           | 3| 9| 7| 2| 5| 1| 3| 3| 1| 4| 6| 2| 3| 3| 6| 4| 7| 1| 6| 9| 9| 6| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |          4              4                                3               |             
      Myelofibrosis                        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +        +              +  +  +              +|             
      Inflammation, Granulomatous          |                                                          3               |             
      Lumbar, Pigmentation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hemorrhage                           |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                                                          4               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             4                       3                       3            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Re Cell                 |          4              4                                4               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                   3                                                      |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Granulomatous          |                   2                                                      |             
      Ulcer                                |    2     4                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |                3                                1           4            |             
      Hydrocephalus                        |    2           2                             2                           |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                            +                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 3                                      3                          3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 4| 3| 5| 7| 6| 6| 6| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 3| 3| 8| 5| 8| 3| 5| 2| 6| 5| 2| 3| 5| 9| 8| 2| 4| 0| 7| 5| 2| 3| 6|             
                                           | 3| 9| 7| 2| 5| 1| 3| 3| 1| 4| 6| 2| 3| 3| 6| 4| 7| 1| 6| 9| 9| 6| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            | 2                                                                 4      |             
      Metaplasia, Squamous                 |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus                              |                                     X                                    |             
      Hemorrhage                           |    1              1  1     1           1  1  1                 1     1   |             
      Infiltration Cellular, Histiocyte    |                                                 1     2                 4|             
      Alveolar Epithelium, Hyperplasia     |             4                                                           2|             
      Alveolus, Fibrosis                   |                                                       2                  |             
      Alveolus, Inflammation, Chronic      |                                        1        1        2           1   |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    2              2     2                       2                    2   |             
      Hemorrhage                           |                         3  3           3                                 |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |    3                                                                 2   |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |    2              1     3                       3                    2   |             
      Respiratory Epithelium, Hyperplasia  |    2                                            3                    1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  4  3  2  1  3  2  4  2  2     1  2  4  2  1  2  3  1  2  2     2  3   |             
      Thrombosis                           |                               X                                          |             
      Cortex, Necrosis                     |                               3                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                      2                                                   |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    2                     |             
      Metaplasia, Squamous                 |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 4| 4| 5| 7| 4| 7| 5| 4| 5| 5| 7| 4| 6| 7| 4| 6| 7| 6| 7| 6| 4|             
                             DAY ON TEST   | 8| 8| 3| 5| 5| 1| 2| 3| 7| 0| 3| 9| 9| 1| 0| 5| 8| 3| 5| 7| 3| 7| 3| 8| 5|             
                                           | 6| 4| 3| 6| 6| 8| 0| 3| 2| 1| 9| 2| 7| 1| 7| 6| 5| 3| 6| 9| 3| 4| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                      X                                      X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X  X  X        X  X                    X        X     X           X|             
      Clear Cell Focus                     |       X                                      X        X     X            |             
      Degeneration, Cystic                 | 1                    1     4              2        4        2     2      |             
      Eosinophilic Focus                   | X     X                                            X                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |    3           3              1     2                                    |             
      Bile Duct, Hyperplasia               |                                           3                              |             
      Hepatocyte, Necrosis                 |                1              1           1                              |             
      Portal, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +        +                       +           +     +   |             
      Hemorrhage                           |                            4                                             |             
      Fat, Inflammation, Granulomatous     |                                                                          |             
      Fat, Necrosis                        |                   3        4                       3           3     2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2     1  2              2                       2     2        2        2|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                3  2                 2                                    |             
      Edema                                |    2                                                                     |             
      Inflammation, Suppurative            |    2              2                 2                                    |             
      Ulcer                                |    4              4                 4                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                         1|             
      Aorta, Inflammation                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 4| 4| 5| 7| 4| 7| 5| 4| 5| 5| 7| 4| 6| 7| 4| 6| 7| 6| 7| 6| 4|             
                             DAY ON TEST   | 8| 8| 3| 5| 5| 1| 2| 3| 7| 0| 3| 9| 9| 1| 0| 5| 8| 3| 5| 7| 3| 7| 3| 8| 5|             
                                           | 6| 4| 3| 6| 6| 8| 0| 3| 2| 1| 9| 2| 7| 1| 7| 6| 5| 3| 6| 9| 3| 4| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2  2        2  2        2           2        2                 2|             
      Atrium, Thrombosis                   |    X                                      X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            | 2                    2     1                                         2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                    4     1              2        3              2  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |          3                                3        3                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      1     1  2                    1        1     1      |             
      Follicle, Dilatation                 |                                              4                           |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    3     3     3              3     3        3     3        3  3        3|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                3                                      3  3              3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       2     2                                            1              2|             
      Epithelium, Hyperplasia              |                                                    2                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     2                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                4                                                         |             
      Inflammation, Suppurative            |                4                                                         |             
      Necrosis                             |                4                                                         |             
      Germinal Epithelium, Atrophy         |                            4           4                             4   |             
      Interstitial Cell, Hyperplasia       |          3  3  3     1  1              3     3           2              3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 4| 4| 5| 7| 4| 7| 5| 4| 5| 5| 7| 4| 6| 7| 4| 6| 7| 6| 7| 6| 4|             
                             DAY ON TEST   | 8| 8| 3| 5| 5| 1| 2| 3| 7| 0| 3| 9| 9| 1| 0| 5| 8| 3| 5| 7| 3| 7| 3| 8| 5|             
                                           | 6| 4| 3| 6| 6| 8| 0| 3| 2| 1| 9| 2| 7| 1| 7| 6| 5| 3| 6| 9| 3| 4| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                        4  3     4        4               |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +              +              +                 +                        |             
      Inflammation, Granulomatous          |                                                                          |             
      Lumbar, Pigmentation                 |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            3              3     3           4            |             
      Hemorrhage                           |                                                             3            |             
      Hyperplasia, Re Cell                 |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                         X                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                           3                              |             
      Hyperkeratosis                       |       4                                                                  |             
      Inflammation, Granulomatous          |                                           4                              |             
      Ulcer                                |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                  3                                       |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                   2           2                          2               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 4| 4| 5| 7| 4| 7| 5| 4| 5| 5| 7| 4| 6| 7| 4| 6| 7| 6| 7| 6| 4|             
                             DAY ON TEST   | 8| 8| 3| 5| 5| 1| 2| 3| 7| 0| 3| 9| 9| 1| 0| 5| 8| 3| 5| 7| 3| 7| 3| 8| 5|             
                                           | 6| 4| 3| 6| 6| 8| 0| 3| 2| 1| 9| 2| 7| 1| 7| 6| 5| 3| 6| 9| 3| 4| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                2         |             
      Inflammation, Suppurative            |                                                                         1|             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus                              |                                                                          |             
      Hemorrhage                           |       1  1  1  1  1     1     1  1           1        1  1              1|             
      Infiltration Cellular, Histiocyte    |             1                                2     2              2      |             
      Alveolar Epithelium, Hyperplasia     |                                                    1                     |             
      Alveolus, Fibrosis                   |                                                                2         |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
      Pleura, Fibrosis                     |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 2                                         2     2                        |             
      Hemorrhage                           |                                                                3     3   |             
      Inflammation, Chronic                | 2                                         2                              |             
      Inflammation, Suppurative            |                                                 3                        |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     | 2                                               2                        |             
      Respiratory Epithelium, Hyperplasia  | 2                                               2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  3  1  1     2  4  1  3  3  2  4  1  3  2  3  2  3  3  4  3  4  4  2|             
      Thrombosis                           |                                                                          |             
      Cortex, Necrosis                     |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |       2                                                     3            |             
      Renal Tubule, Hyperplasia            |                                                                   4      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     3                                    |             
      Metaplasia, Squamous                 |                                     2                                    |             
      Ulcer                                |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 4| 7| 7|                                                        |            |
                             DAY ON TEST   | 4| 0| 3| 5| 3| 3|                                                        |            |
                                           | 6| 2| 3| 6| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  56        |
      Lumen, Parasite Metazoan             |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  55        |
      Lumen, Parasite Metazoan             |       X                                                                  |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  55        |
      Lumen, Parasite Metazoan             |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  55        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  56        |
      Basophilic Focus                     |       X     X                                                            |     21     |
      Clear Cell Focus                     |                                                                          |      6     |
      Degeneration, Cystic                 |                                                                          |     16  2.0|
      Eosinophilic Focus                   |                                                                          |      3     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hepatodiaphragmatic Nodule           | X                                                                        |      2     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mixed Cell Focus                     |       X                                                                  |      1     |
      Vacuolization Cytoplasmic            | 4              1                                                         |     11  2.6|
      Bile Duct, Hyperplasia               |                                                                          |      2  3.0|
      Hepatocyte, Necrosis                 |                                                                          |      7  1.1|
      Portal, Fibrosis                     |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  10        |
      Hemorrhage                           |                                                                          |      3  4.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      7  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  56        |
      Acinus, Atrophy                      | 1  2           2                                                         |     24  1.7|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  56        |
      Acanthosis                           | 2                                                                        |      4  2.3|
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 2                                                                        |      5  2.0|
      Ulcer                                | 3                                                                        |      4  3.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  56        |
      Ulcer                                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 4| 7| 7|                                                        |            |
                             DAY ON TEST   | 4| 0| 3| 5| 3| 3|                                                        |            |
                                           | 6| 2| 3| 6| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +                                                         |  56        |
      Mineralization                       |                                                                          |      1  1.0|
      Aorta, Inflammation                  |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  56        |
      Cardiomyopathy                       |    2  2                                                                  |     14  2.0|
      Atrium, Thrombosis                   | X                                                                        |      8     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  56        |
      Vacuolization Cytoplasmic            |                                                                          |      7  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia                          |    3           2                                                         |     20  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +                                                         |  54        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  56        |
      Cyst                                 |                X                                                         |      3     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |             3                                                            |      8  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  56        |
      C-Cell, Hyperplasia                  |             1                                                            |     10  1.4|
      Follicle, Dilatation                 |                                                                          |      1  4.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  55        |
      Ectasia                              | 3     3                                                                  |     22  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                | 3                                                                        |      1  3.0|
      Inflammation, Suppurative            |             3                                                            |      7  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 4| 7| 7|                                                        |            |
                             DAY ON TEST   | 4| 0| 3| 5| 3| 3|                                                        |            |
                                           | 6| 2| 3| 6| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |             2                                                            |      9  1.9|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  56        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Germinal Epithelium, Atrophy         |                                                                          |     10  4.0|
      Interstitial Cell, Hyperplasia       | 3  2     3                                                               |     21  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia, Re Cell                 |                                                                          |      7  3.7|
      Myelofibrosis                        | 2                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |  12        |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Lumbar, Pigmentation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  M  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  M  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  55        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  56        |
      Fibrosis                             |                                                                          |      7  3.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Re Cell                 |                                                                          |      4  3.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  55        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  55        |
      Galactocele                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  56        |
      Acanthosis                           |                                                                          |      2  3.0|
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |                                                                          |      2  3.0|
      Ulcer                                |       2                                                                  |      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 4| 7| 7|                                                        |            |
                             DAY ON TEST   | 4| 0| 3| 5| 3| 3|                                                        |            |
                                           | 6| 2| 3| 6| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  56        |
      Gliosis                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      3  2.7|
      Hydrocephalus                        |                2                                                         |      7  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  56        |
      Foreign Body                         |             3                                                            |      4  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |       2     2                                                            |      5  2.2|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  56        |
      Embolus                              |                                                                          |      1     |
      Hemorrhage                           |    1     1  1                                                            |     24  1.0|
      Infiltration Cellular, Histiocyte    |    1     1  1                                                            |     10  1.7|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.3|
      Alveolus, Fibrosis                   |                                                                          |      2  2.0|
      Alveolus, Inflammation, Chronic      |                                                                          |      4  1.3|
      Pleura, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  56        |
      Foreign Body                         |    2           2                                                         |     10  2.0|
      Hemorrhage                           |    3                                                                     |      6  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                2                                                         |      4  2.5|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hypertrophy                     |    2           2                                                         |      9  2.1|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 4| 7| 7|                                                        |            |
                             DAY ON TEST   | 4| 0| 3| 5| 3| 3|                                                        |            |
                                           | 6| 2| 3| 6| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  56        |
      Nephropathy, Chronic                 | 2  2  3  2  3  4                                                         |     52  2.5|
      Thrombosis                           |                                                                          |      1     |
      Cortex, Necrosis                     |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      3  2.3|
      Renal Tubule, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|             
                             DAY ON TEST   | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|             
                                           | 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  +  A  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A  +  +|             
      Lumen, Parasite Metazoan             |    X                                            X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Diverticulum                         |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X     X  X  X     X  X  X     X  X           X        X     X         |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                         4  2     2           2  4        2              2|             
      Eosinophilic Focus                   |                   X  X                          X              X         |             
      Granuloma, Multifocal                |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |       2     2                             2  3        3                  |             
      Bile Duct, Hyperplasia               |                                                                      4   |             
      Hepatocyte, Necrosis                 |    2  2           1                                                     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +                                            +     +         |             
      Fat, Inflammation, Granulomatous     |                                                                          |             
      Fat, Necrosis                        |    3        4                                            4     3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          2  1  1  1  1  2     2  2  1  2     1        2  1  2  1        2|             
      Artery, Inflammation                 |                                                                          |             
      Duct, Cyst                           |                                                                         X|             
      Duct, Hyperplasia                    |                                                                         4|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Acanthosis                           |                                                       3     2            |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                               2                                          |             
      Inflammation, Suppurative            |             3                                         3                  |             
      Mineralization                       |                                                                          |             
      Ulcer                                |             4                                2        4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|             
                             DAY ON TEST   | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|             
                                           | 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Aorta, Inflammation                  |                                                                          |             
      Aorta, Mineralization                |                               4                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2                             2                             2   |             
      Atrium, Thrombosis                   |       X                                   X  X                           |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Vacuolization Cytoplasmic            |                         1                       1                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +  M  +  +|             
      Hyperplasia                          |    3  2                          2              2              2     4   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2     3                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  I  +  +|             
      Cyst                                 |             X                                         X                  |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |       3              3                 3              3                  |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      1     2                 2           1              1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Ectasia                              |                   3  3                    3           3                 3|             
      Granuloma                            |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                   3                 3     3                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |    2        2              2  3                          3               |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|             
                             DAY ON TEST   | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|             
                                           | 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +|             
      Hyperplasia                          |                               3                                          |             
      Inflammation, Suppurative            |          1                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Germinal Epithelium, Atrophy         |    4              4     4                                4     4     4   |             
      Interstitial Cell, Hyperplasia       | 1           3                    3  3  4                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                   +  +           +   |             
      Lumbar, Pigmentation                 |                                                                          |             
      Renal, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +     +  +  +  +  M  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hemorrhage                           |             4                                                            |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hemorrhage                           | 3              3           3                                             |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Developmental Malformation           |                                              X                           |             
      Fibrosis                             |       4     4  4     4  4  2                                         4   |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Galactocele                          |                         X                                                |             
      Inflammation, Chronic                |                         3                                                |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Acanthosis                           |                            2                                             |             
      Cyst                                 |                            2                                             |             
      Cyst Epithelial Inclusion            |                      X                                                   |             
      Hyperkeratosis                       |                      4     2                                             |             
      Inflammation, Chronic                |                            3                                             |             
      Inflammation, Granulomatous          |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|             
                             DAY ON TEST   | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|             
                                           | 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Developmental Malformation           |                         X                                                |             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Demyelination                        |                                                                          |             
      Hemorrhage                           |             3                                   3                        |             
      Hydrocephalus                        | 2                                               2           2            |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Foreign Body                         |    3                                                                     |             
      Hyperplasia                          |    2                                                                 2   |             
      Inflammation, Suppurative            |    2                                                                 2   |             
      Metaplasia, Squamous                 |    2              1                                                      |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1     1     1  1  1  1  1  1  1  1  1  1     1     1  1  1  1     1  1|             
      Infiltration Cellular, Histiocyte    |    1  2  1        2                 3  1                 3     2         |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          1                          3                    3     3     2   |             
      Alveolus, Fibrosis                   |                                                                          |             
      Alveolus, Mineralization             |                                                                          |             
      Alveolus, Pigmentation               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Foreign Body                         |          2                                                        2  2  2|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |    2                                                                 2   |             
      Inflammation, Suppurative            |                               1                                   1      |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |    2                                                                    3|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                      3  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cataract                             |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 6| 7| 6| 7| 7| 7| 4| 5| 4| 4| 5| 5| 7| 0| 6| 7| 5| 7| 5| 6| 5|             
                             DAY ON TEST   | 6| 3| 9| 5| 4| 3| 3| 3| 3| 3| 9| 5| 5| 5| 5| 6| 3| 5| 8| 1| 2| 3| 9| 2| 3|             
                                           | 0| 3| 3| 6| 2| 3| 7| 3| 3| 3| 6| 8| 6| 6| 5| 4| 3| 6| 8| 8| 5| 3| 5| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  4  2  2  2  3  2  3  4  4  3  2  1  1  1  2  3     4  3  2  3  2  3  2|             
      Cortex, Necrosis                     |                                                       3                  |             
      Pelvis, Dilatation                   |                               4                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                         2                                                |             
      Renal Tubule, Mineralization         |                               3                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hemorrhage                           |                               4                                          |             
      Inflammation, Suppurative            |                               4                                          |             
      Mineralization                       |                               3                                          |             
      Transitional Epithelium, Hyperplasia |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|             
                             DAY ON TEST   | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|             
                                           | 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lumen, Parasite Metazoan             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lumen, Parasite Metazoan             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lumen, Parasite Metazoan             |                   X  X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           4                              |             
      Basophilic Focus                     | X     X        X           X        X  X     X  X     X     X     X  X  X|             
      Clear Cell Focus                     |                                                    X                     |             
      Degeneration, Cystic                 |          3              1  3              4  4  3  1  2     3  1         |             
      Eosinophilic Focus                   |          X           X     X                                             |             
      Granuloma, Multifocal                |                                                             3            |             
      Hepatodiaphragmatic Nodule           |             X                 X        X                                 |             
      Mixed Cell Focus                     |                                              X                           |             
      Pigmentation, Hemosiderin            |                                                    3                     |             
      Vacuolization Cytoplasmic            |             2              2           1                 4               |             
      Bile Duct, Hyperplasia               |                            4                                             |             
      Hepatocyte, Necrosis                 |                   1        2                    2              3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +                    +        +     +               |             
      Fat, Inflammation, Granulomatous     |                                           4                              |             
      Fat, Necrosis                        |                   4  4                                   3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1  2  1  2  2  2     2  1  2  2           2     2  2        1        1  1|             
      Artery, Inflammation                 |                               4                                          |             
      Duct, Cyst                           |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                           2              3               |             
      Edema                                |       3                                   3              3               |             
      Hyperkeratosis                       |                                                          3               |             
      Inflammation, Suppurative            |                                           2              3               |             
      Mineralization                       |                3                                                         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                3                                                         |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|             
                             DAY ON TEST   | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|             
                                           | 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                     +                       +            |             
      Epithelium, Hyperplasia              |                                     3                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation                  |                3                                                         |             
      Aorta, Mineralization                |                3                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2     2  2        2  2                                      2      |             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Mineralization           |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
      Vacuolization Cytoplasmic            |    1              2        2  3                    3     2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2              2  3  1     2  4                 3  2  3                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +|             
      Hyperplasia                          |                3        2                       2                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X     X  X  X     X                                                   |             
      Hemorrhage                           |    4                                                                     |             
      Pars Distalis, Hyperplasia           |          3        3                                               3  3   |             
      Pars Intermedia, Hyperplasia         |                                           3                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2                          2        2  1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             3  3  3     3  3  3                 3  3              3  3   |             
      Granuloma                            |                                                                          |             
      Hyperplasia                          |             3                 3                                          |             
      Inflammation, Suppurative            |                               3              3           3           3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                                             |             
      Inflammation, Suppurative            |                4           3        2  2                                 |             
      Epithelium, Hyperplasia              |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|             
                             DAY ON TEST   | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|             
                                           | 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                2                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              4                           |             
      Germinal Epithelium, Atrophy         |          4              4  4        4           4  4        4            |             
      Interstitial Cell, Hyperplasia       | 3  3  3           2                    3           2     3        3  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                     +                  |             
      Lumbar, Pigmentation                 |                                                                          |             
      Renal, Ectasia                       | 4                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                4         |             
      Hyperplasia, Lymphoid                |       3                                                     3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Granulomatous          |                               4                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|             
      Hemorrhage                           |       3                                                        3         |             
      Pigmentation                         |                                                    4                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                           X                              |             
      Fibrosis                             |             4              3        3                             2      |             
      Hyperplasia, Re Cell                 |                                                                   3      |             
      Necrosis                             |             4                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                    X                     |             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                    4                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               4                                          |             
      Cyst                                 |                                                                          |             
      Cyst Epithelial Inclusion            |                X                                                         |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                           4                              |             
      Ulcer                                |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|             
                             DAY ON TEST   | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|             
                                           | 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Demyelination                        |    4                                                                     |             
      Hemorrhage                           |    3                                   1                                 |             
      Hydrocephalus                        |                               2  2                 2     2               |             
      Necrosis                             |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    3                                                  3              3   |             
      Hyperplasia                          |    3                    2                                                |             
      Inflammation, Suppurative            |                                                                3         |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |       1                                                                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1  1  1  1     1        1  1  1        1     1              1  1   |             
      Infiltration Cellular, Histiocyte    |                         2  4              2     1     3                  |             
      Metaplasia, Osseous                  |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
      Alveolus, Fibrosis                   |                            3                                             |             
      Alveolus, Mineralization             |                3                                                         |             
      Alveolus, Pigmentation               |                            3                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          2     2              2           2     2                        |             
      Hemorrhage                           |                                        3                          3      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                2                          3                              |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |                2                          3                              |             
      Olfactory Epithelium, Metaplasia     |          3                                                               |             
      Respiratory Epithelium, Hyperplasia  |          3     3                          3                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 7| 5| 7| 5| 6| 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 4| 4| 6|             
                             DAY ON TEST   | 6| 9| 4| 3| 8| 0| 8| 3| 8| 0| 2| 3| 3| 6| 2| 3| 3| 6| 3| 1| 3| 8| 5| 5| 5|             
                                           | 7| 0| 6| 3| 6| 1| 6| 9| 9| 7| 1| 1| 3| 5| 3| 3| 3| 5| 3| 7| 2| 8| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|             
                                           | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  1  3  2  4  2  2  4  4  3  1  4  2  3  2  4  3  4  4  3  2  2  2  2|             
      Cortex, Necrosis                     |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                2           2                                             |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Transitional Epithelium, Hyperplasia |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 7| 4|                                                        |            |
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5|                                                        |            |
                                           | 9| 6| 1| 6| 3| 6|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 6|                                                        |      L     |
                                           | 3| 4| 5| 6| 7| 8|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  50        |
      Lumen, Parasite Metazoan             |       X                                                                  |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  52        |
      Lumen, Parasite Metazoan             |             X                                                            |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  +                                                         |  51        |
      Lumen, Parasite Metazoan             |       X                                                                  |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  53        |
      Diverticulum                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  55        |
      Angiectasis                          |                                                                          |      1  4.0|
      Basophilic Focus                     |    X     X  X                                                            |     28     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |     17  2.5|
      Eosinophilic Focus                   |                                                                          |      7     |
      Granuloma, Multifocal                |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |             X                                                            |      4     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |             1                                                            |     10  2.2|
      Bile Duct, Hyperplasia               |                                                                          |      2  4.0|
      Hepatocyte, Necrosis                 |                                                                          |      8  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   9        |
      Fat, Inflammation, Granulomatous     |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      7  3.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  55        |
      Acinus, Atrophy                      | 1  1  2                                                                  |     35  1.5|
      Artery, Inflammation                 |                                                                          |      1  4.0|
      Duct, Cyst                           |                                                                          |      1     |
      Duct, Hyperplasia                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  55        |
      Acanthosis                           |                                                                          |      4  2.5|
      Edema                                |                                                                          |      3  3.0|
      Hyperkeratosis                       |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 7| 4|                                                        |            |
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5|                                                        |            |
                                           | 9| 6| 1| 6| 3| 6|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 6|                                                        |      L     |
                                           | 3| 4| 5| 6| 7| 8|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  54        |
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +                                                         |  54        |
      Aorta, Inflammation                  |                                                                          |      1  3.0|
      Aorta, Mineralization                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  55        |
      Cardiomyopathy                       |          2                                                               |     11  2.0|
      Atrium, Thrombosis                   |                                                                          |      3     |
      Myocardium, Mineralization           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  55        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      8  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  53        |
      Hyperplasia                          |             3                                                            |     16  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +                                                         |  49        |
      Hyperplasia                          |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  53        |
      Cyst                                 |                                                                          |      7     |
      Hemorrhage                           | 4                                                                        |      2  4.0|
      Pars Distalis, Hyperplasia           |          3                                                               |      9  3.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  55        |
      C-Cell, Hyperplasia                  |             1                                                            |     10  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 7| 4|                                                        |            |
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5|                                                        |            |
                                           | 9| 6| 1| 6| 3| 6|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 6|                                                        |      L     |
                                           | 3| 4| 5| 6| 7| 8|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  55        |
      Ectasia                              | 3                                                                        |     16  3.0|
      Granuloma                            |                4                                                         |      1  4.0|
      Hyperplasia                          |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      7  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  55        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Suppurative            |          2                                                               |     10  2.5|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  54        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  55        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Germinal Epithelium, Atrophy         |                                                                          |     13  4.0|
      Interstitial Cell, Hyperplasia       | 1  3  1  3     3                                                         |     19  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +                                                                  |   8        |
      Lumbar, Pigmentation                 |    2                                                                     |      1  2.0|
      Renal, Ectasia                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  51        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  55        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  53        |
      Hemorrhage                           |                                                                          |      5  3.0|
      Pigmentation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  55        |
      Developmental Malformation           |                                                                          |      2     |
      Fibrosis                             | 4  2                                                                     |     13  3.4|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 7| 4|                                                        |            |
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5|                                                        |            |
                                           | 9| 6| 1| 6| 3| 6|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 6|                                                        |      L     |
                                           | 3| 4| 5| 6| 7| 8|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  52        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  55        |
      Galactocele                          |                                                                          |      2     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  55        |
      Acanthosis                           |                                                                          |      2  3.0|
      Cyst                                 |                                                                          |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Hyperkeratosis                       |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  55        |
      Developmental Malformation           |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  55        |
      Demyelination                        |                                                                          |      1  4.0|
      Hemorrhage                           | 3                                                                        |      5  2.6|
      Hydrocephalus                        |                                                                          |      7  2.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | I  +  +  +  +  +                                                         |  54        |
      Foreign Body                         |                                                                          |      4  3.0|
      Hyperplasia                          |                                                                          |      4  2.3|
      Inflammation, Suppurative            |                                                                          |      3  2.3|
      Metaplasia, Squamous                 |                                                                          |      2  1.5|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  55        |
      Hemorrhage                           | 1  1     1  1  1                                                         |     37  1.0|
      Infiltration Cellular, Histiocyte    | 4           3  1                                                         |     16  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 7| 4|                                                        |            |
                             DAY ON TEST   | 5| 5| 6| 5| 3| 5|                                                        |            |
                                           | 9| 6| 1| 6| 3| 6|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 6|                                                        |      L     |
                                           | 3| 4| 5| 6| 7| 8|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |      7  2.1|
      Alveolus, Fibrosis                   |                                                                          |      1  3.0|
      Alveolus, Mineralization             |                                                                          |      1  3.0|
      Alveolus, Pigmentation               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  55        |
      Foreign Body                         |                                                                          |      9  2.0|
      Hemorrhage                           |       3                                                                  |      3  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      4  1.8|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hypertrophy                     |                                                                          |      4  2.5|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  55        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  55        |
      Nephropathy, Chronic                 | 2  1  2  1  3  2                                                         |     55  2.5|
      Cortex, Necrosis                     |                                                                          |      1  3.0|
      Pelvis, Dilatation                   |                                                                          |      1  4.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      3  2.0|
      Renal Tubule, Mineralization         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  55        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 6| 4| 4| 3| 5| 7| 4| 5| 6| 7| 4| 7| 7| 5| 7| 6| 5| 7| 6| 7| 4|             
                             DAY ON TEST   | 2| 7| 6| 2| 5| 5| 9| 7| 0| 3| 4| 6| 9| 1| 8| 3| 3| 8| 0| 4| 9| 3| 8| 3| 5|             
                                           | 2| 3| 1| 5| 3| 6| 7| 1| 7| 3| 2| 0| 8| 9| 3| 3| 3| 3| 7| 4| 7| 3| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                            X                    X              X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   4      |             
      Basophilic Focus                     | X     X        X     X  X  X                 X  X     X     X  X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                            2                          2                  |             
      Eosinophilic Focus                   |                                                 X     X           X  X   |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |    2     3                       3                 3                     |             
      Bile Duct, Hyperplasia               |                                           2                       4      |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                          +         |             
      Hemorrhage                           |                                                                          |             
      Fat, Inflammation, Granulomatous     |                                                                4         |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1     2  2              1     1  2  2     2        1  2  2     2  1  2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                   2              3        2        2                     |             
      Diverticulum                         |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Suppurative            |                   3  4                             2                     |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                      4                                                   |             
      Ulcer                                |                   3  4           3                 1                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  3                                       |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 6| 4| 4| 3| 5| 7| 4| 5| 6| 7| 4| 7| 7| 5| 7| 6| 5| 7| 6| 7| 4|             
                             DAY ON TEST   | 2| 7| 6| 2| 5| 5| 9| 7| 0| 3| 4| 6| 9| 1| 8| 3| 3| 8| 0| 4| 9| 3| 8| 3| 5|             
                                           | 2| 3| 1| 5| 3| 6| 7| 1| 7| 3| 2| 0| 8| 9| 3| 3| 3| 3| 7| 4| 7| 3| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2              2                             2                          2|             
      Atrium, Thrombosis                   |             X                                      X                     |             
      Myocardium, Mineralization           |                                                                          |             
      Myocardium, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                        2                                 |             
      Vacuolization Cytoplasmic            |                                              1  1              2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |             3                       2  2     3        3  2  2  3  4      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                3                                      3              3  3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                         X|             
      C-Cell, Hyperplasia                  |                      1                 2                             4   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3  3        3        3     3     3     3        3     3              3  3|             
      Hyperplasia                          |                3                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |             3        3                                                  3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          4           4                                                   |             
      Epithelium, Hyperplasia              |                                                 1                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 6| 4| 4| 3| 5| 7| 4| 5| 6| 7| 4| 7| 7| 5| 7| 6| 5| 7| 6| 7| 4|             
                             DAY ON TEST   | 2| 7| 6| 2| 5| 5| 9| 7| 0| 3| 4| 6| 9| 1| 8| 3| 3| 8| 0| 4| 9| 3| 8| 3| 5|             
                                           | 2| 3| 1| 5| 3| 6| 7| 1| 7| 3| 2| 0| 8| 9| 3| 3| 3| 3| 7| 4| 7| 3| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                            4        4                                    |             
      Interstitial Cell, Hyperplasia       |          3  4  3  2  1        3  2        3                    3  1     3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +                 +  +  +  +                 +               |             
      Lumbar, Pigmentation                 |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                              X                           |             
      Fibrosis                             |       3                                      4  3     4        4  4  4   |             
      Necrosis                             |                                                          4               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                         X                                      X         |             
      Hemorrhage                           |                                                                          |             
      Epithelium, Hyperplasia              |                                                                3     3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                1                                                         |             
      Cyst Epithelial Inclusion            |                                              X                           |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Granulomatous          |                3                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 5| 6| 4| 4| 3| 5| 7| 4| 5| 6| 7| 4| 7| 7| 5| 7| 6| 5| 7| 6| 7| 4|             
                             DAY ON TEST   | 2| 7| 6| 2| 5| 5| 9| 7| 0| 3| 4| 6| 9| 1| 8| 3| 3| 8| 0| 4| 9| 3| 8| 3| 5|             
                                           | 2| 3| 1| 5| 3| 6| 7| 1| 7| 3| 2| 0| 8| 9| 3| 3| 3| 3| 7| 4| 7| 3| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        4                                 |             
      Hydrocephalus                        |                   2  2  2                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             3                                         3                  |             
      Hyperplasia                          |                                           2                              |             
      Inflammation, Suppurative            |             2                                            2               |             
      Metaplasia, Squamous                 |                                           2                              |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          1     1  1  1  1  1  1              1  1           1  1     1  1|             
      Infarct                              |          4                                                               |             
      Infiltration Cellular, Histiocyte    |                               1                    2  2  2               |             
      Thrombosis                           |          X                                                               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Fibrosis                   |                                                    2  2                  |             
      Alveolus, Mineralization             |                                                                          |             
      Alveolus, Pigmentation               |                                                    2                     |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       2                    2        2                                    |             
      Hemorrhage                           |                                     3                             3      |             
      Inflammation, Chronic                |                                     2                       2            |             
      Inflammation, Suppurative            |             3                                                            |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |             3                 2                                   2      |             
      Respiratory Epithelium, Hyperplasia  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         M                                      +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  2  2  2  1  2  2  2  4  1  2  4  4     4  3  3  3  2  2  3  3  4  2|             
      Cortex, Necrosis                     |                                        4                 3     3         |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                       4                  |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 5| 4| 6| 6| 6| 4| 6| 6| 5| 6| 5| 7| 7| 7| 4| 7| 6| 3| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 5| 0| 9| 5| 7| 3| 0| 8| 1| 4| 3| 2| 8| 0| 0| 3| 5| 3| 6| 9| 3| 6|             
                                           | 1| 5| 7| 6| 9| 3| 6| 4| 7| 1| 0| 8| 2| 9| 9| 7| 5| 0| 3| 6| 3| 6| 5| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                       X     X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X     X  X  X  X  X  X           X                 X  X  X  X  X  X   |             
      Clear Cell Focus                     |                                                             X        X   |             
      Degeneration, Cystic                 |    3                                2           4           1            |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                     X        X                       X   |             
      Mixed Cell Focus                     |                                                             X            |             
      Vacuolization Cytoplasmic            |                            4     2  3  3     4  4                       4|             
      Bile Duct, Hyperplasia               |                                                    3                     |             
      Hepatocyte, Necrosis                 |                                                 3                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                          +        +           +  +              +   |             
      Hemorrhage                           |                                                    4                     |             
      Fat, Inflammation, Granulomatous     |                                        2                             2   |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2  2           1     1              1  2  2        2           2     1  2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                         2        2  3     1  4                          4|             
      Diverticulum                         |                      3                                         2         |             
      Edema                                |                                           3                              |             
      Inflammation, Suppurative            |                                     3     2  4                          4|             
      Mineralization                       |                                                 3                        |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                     4        4                          3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                            3                                             |             
      Mineralization                       |                                                 4                        |             
      Necrosis                             |                            3                                             |             
      Ulcer                                |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 5| 4| 6| 6| 6| 4| 6| 6| 5| 6| 5| 7| 7| 7| 4| 7| 6| 3| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 5| 0| 9| 5| 7| 3| 0| 8| 1| 4| 3| 2| 8| 0| 0| 3| 5| 3| 6| 9| 3| 6|             
                                           | 1| 5| 7| 6| 9| 3| 6| 4| 7| 1| 0| 8| 2| 9| 9| 7| 5| 0| 3| 6| 3| 6| 5| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                 4                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2  2           2        2                    2     2        2      |             
      Atrium, Thrombosis                   |                                                 X                        |             
      Myocardium, Mineralization           |                                                 4                        |             
      Myocardium, Necrosis                 |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        3                          2      |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |    2  2                                      3  2                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1  4              1           3              3  4  1     3  2     2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             4                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |    2                                            3           2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                 X     X           X                       X|             
      Hemorrhage                           |                                                                   4      |             
      Pars Distalis, Hyperplasia           | 3                 3           3                                3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       2                             1     2                    2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    3  3  3     3  3  3              3        3  3        3        3  3   |             
      Hyperplasia                          |             3                                                            |             
      Inflammation, Chronic                |          2        2                                      3               |             
      Inflammation, Suppurative            |                                                                3  3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3           1                       3                 2              3  3|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3                                                   |             
      Inflammation, Suppurative            |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 5| 4| 6| 6| 6| 4| 6| 6| 5| 6| 5| 7| 7| 7| 4| 7| 6| 3| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 5| 0| 9| 5| 7| 3| 0| 8| 1| 4| 3| 2| 8| 0| 0| 3| 5| 3| 6| 9| 3| 6|             
                                           | 1| 5| 7| 6| 9| 3| 6| 4| 7| 1| 0| 8| 2| 9| 9| 7| 5| 0| 3| 6| 3| 6| 5| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 4  4  4                          4  4              4                 4   |             
      Interstitial Cell, Hyperplasia       | 2        3              2     2        1     1                    3     1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +        +           +  +     +        +     +         |             
      Lumbar, Pigmentation                 |                                                 2        2               |             
      Renal, Pigmentation                  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                    2           2         |             
      Hemorrhage                           |                                                 3                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                           X                              |             
      Fibrosis                             | 4     4     4                    4        3     4  4                 4   |             
      Necrosis                             |                                     4                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hemorrhage                           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                             X            |             
      Hemorrhage                           |                                                             4            |             
      Epithelium, Hyperplasia              | 3                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             3                                                  4         |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                4         |             
      Inflammation, Granulomatous          |                   3                                                      |             
      Inflammation, Suppurative            |                                                                1         |             
      Ulcer                                |             4                                                            |             
      Subcutaneous Tissue, Hemorrhage      |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 4| 7| 5| 4| 6| 6| 6| 4| 6| 6| 5| 6| 5| 7| 7| 7| 4| 7| 6| 3| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 5| 0| 9| 5| 7| 3| 0| 8| 1| 4| 3| 2| 8| 0| 0| 3| 5| 3| 6| 9| 3| 6|             
                                           | 1| 5| 7| 6| 9| 3| 6| 4| 7| 1| 0| 8| 2| 9| 9| 7| 5| 0| 3| 6| 3| 6| 5| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2     4     4                          4     3|             
      Hydrocephalus                        |                2     2  2                    2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         3        3                 3                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                  2                 2                     |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1  1  1  1  1  1     1              1        1     1  1  1  1  1  1   |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Histiocyte    | 3                 1           4     2              2  1     2     1  1   |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   1           2     1                       2            |             
      Alveolus, Fibrosis                   | 2                             2     2              1                     |             
      Alveolus, Mineralization             |                                                 4                        |             
      Alveolus, Pigmentation               |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                          3               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       2                             2        2                          2|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                         2|             
      Inflammation, Suppurative            |    3  2                                         2  1           1         |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |    3  4                                      3  2  2                     |             
      Respiratory Epithelium, Hyperplasia  |    3  3                                1     3                 2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  4  4  2  2  3  1  4  2  2  2  2  1  1  2  3  4  2  4  1  4  3  1  3  3|             
      Cortex, Necrosis                     |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                 2                        |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization         |                                                 4                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6|                                                        |            |
                             DAY ON TEST   | 3| 8| 5| 5| 5| 7|                                                        |            |
                                           | 3| 4| 6| 6| 6| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    200 PPM                                | 7| 7| 7| 7| 7| 8|                                                        |      L     |
                                           | 5| 6| 7| 8| 9| 0|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  54        |
      Lumen, Parasite Metazoan             |    X           X                                                         |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  55        |
      Lumen, Parasite Metazoan             |    X                                                                     |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  54        |
      Lumen, Parasite Metazoan             |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  54        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  56        |
      Angiectasis                          |                                                                          |      1  4.0|
      Basophilic Focus                     | X  X  X  X                                                               |     32     |
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic                 |    1           4                                                         |      8  2.4|
      Eosinophilic Focus                   |                X                                                         |      5     |
      Hepatodiaphragmatic Nodule           |       X                                                                  |      5     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Vacuolization Cytoplasmic            | 2                                                                        |     12  3.1|
      Bile Duct, Hyperplasia               |                                                                          |      3  3.0|
      Hepatocyte, Necrosis                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   9        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      3  2.7|
      Fat, Necrosis                        |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  56        |
      Acinus, Atrophy                      |    1  2     1  2                                                         |     29  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  56        |
      Acanthosis                           |                                                                          |     10  2.5|
      Diverticulum                         |                                                                          |      2  2.5|
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      7  3.1|
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      7  3.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6|                                                        |            |
                             DAY ON TEST   | 3| 8| 5| 5| 5| 7|                                                        |            |
                                           | 3| 4| 6| 6| 6| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    200 PPM                                | 7| 7| 7| 7| 7| 8|                                                        |      L     |
                                           | 5| 6| 7| 8| 9| 0|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +                                                         |  56        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  56        |
      Cardiomyopathy                       |             2                                                            |     12  2.0|
      Atrium, Thrombosis                   |                                                                          |      3     |
      Myocardium, Mineralization           |                                                                          |      1  4.0|
      Myocardium, Necrosis                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 2              4                                                         |     10  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  53        |
      Hyperplasia                          | 2              2                                                         |     21  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia                          |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  54        |
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  56        |
      Cyst                                 |    X           X                                                         |      8     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |       3                                                                  |      9  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  56        |
      Ultimobranchial Cyst                 |       X                                                                  |      2     |
      C-Cell, Hyperplasia                  |       1  1                                                               |      9  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  56        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  55        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6|                                                        |            |
                             DAY ON TEST   | 3| 8| 5| 5| 5| 7|                                                        |            |
                                           | 3| 4| 6| 6| 6| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    200 PPM                                | 7| 7| 7| 7| 7| 8|                                                        |      L     |
                                           | 5| 6| 7| 8| 9| 0|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              | 3     3                                                                  |     25  3.0|
      Hyperplasia                          |                                                                          |      2  3.0|
      Inflammation, Chronic                |          2                                                               |      4  2.3|
      Inflammation, Suppurative            | 3                                                                        |      6  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  56        |
      Inflammation, Suppurative            |                2                                                         |      9  2.8|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  56        |
      Germinal Epithelium, Atrophy         |                                                                          |      9  4.0|
      Interstitial Cell, Hyperplasia       |       3  3                                                               |     21  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  15        |
      Lumbar, Pigmentation                 |                                                                          |      2  2.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  +  +  +                                                         |  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  M                                                         |  52        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  55        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  56        |
      Fibrosis                             |    2                                                                     |      3  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  56        |
      Developmental Malformation           |                                                                          |      2     |
      Fibrosis                             | 3  4           4                                                         |     18  3.8|
      Necrosis                             |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  54        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  56        |
      Galactocele                          |                                                                          |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6|                                                        |            |
                             DAY ON TEST   | 3| 8| 5| 5| 5| 7|                                                        |            |
                                           | 3| 4| 6| 6| 6| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    200 PPM                                | 7| 7| 7| 7| 7| 8|                                                        |      L     |
                                           | 5| 6| 7| 8| 9| 0|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  56        |
      Acanthosis                           |                                                                          |      3  2.7|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |             3                                                            |      3  3.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  4.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      6  3.5|
      Hydrocephalus                        |                                                                          |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  56        |
      Foreign Body                         |                                                                          |      5  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      4  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           | 1  1  1  1  1                                                            |     34  1.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    |    3                                                                     |     14  1.9|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.5|
      Alveolus, Fibrosis                   |    2                                                                     |      7  1.9|
      Alveolus, Mineralization             |                                                                          |      1  4.0|
      Alveolus, Pigmentation               |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  56        |
      Foreign Body                         |                                                                          |      7  2.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 6|                                                        |            |
                             DAY ON TEST   | 3| 8| 5| 5| 5| 7|                                                        |            |
                                           | 3| 4| 6| 6| 6| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    200 PPM                                | 7| 7| 7| 7| 7| 8|                                                        |      L     |
                                           | 5| 6| 7| 8| 9| 0|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      6  2.0|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hypertrophy                     |                                                                          |      8  2.6|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  56        |
      Nephropathy, Chronic                 | 4  2  1  2  1  2                                                         |     55  2.5|
      Cortex, Necrosis                     |                                                                          |      3  3.3|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  4.0|
      Renal Tubule, Mineralization         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 5| 6| 4| 6| 7| 7| 6| 7| 7| 7| 6| 4| 4| 7| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 5| 3| 8| 2| 5| 5| 1| 3| 9| 2| 3| 3| 2| 5| 5| 3| 7| 5| 5| 8| 6| 3| 3| 4|             
                                           | 3| 6| 3| 8| 3| 6| 0| 6| 3| 1| 7| 3| 3| 8| 6| 6| 3| 2| 6| 6| 3| 5| 3| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X     X  X  X  X  X        X     X  X  X  X     X  X  X  X  X      |             
      Clear Cell Focus                     |    X                    X                                                |             
      Degeneration, Cystic                 |                               2                                          |             
      Eosinophilic Focus                   | X                          X  X     X                                   X|             
      Hepatodiaphragmatic Nodule           |                         X                          X                     |             
      Mixed Cell Focus                     |                                                                   X      |             
      Thrombosis                           |                      X                                               2   |             
      Vacuolization Cytoplasmic            |                   3                                                      |             
      Hepatocyte, Necrosis                 |                                     4              1                 1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +  +           +        +     +                 +      |             
      Hemorrhage                           |          4           4                                            4      |             
      Fat, Inflammation, Granulomatous     |                                           3                              |             
      Fat, Necrosis                        |                   2  4                    3     2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      4                                                   |             
      Acinus, Atrophy                      |          2  1  1     4  2  2  2  2     1     2  2  2           2  2  4  2|             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      3                                         2         |             
      Diverticulum                         |                                        3                                 |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                      3                                         4         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                    2                     |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2              2              2        2  2              2  2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 5| 6| 4| 6| 7| 7| 6| 7| 7| 7| 6| 4| 4| 7| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 5| 3| 8| 2| 5| 5| 1| 3| 9| 2| 3| 3| 2| 5| 5| 3| 7| 5| 5| 8| 6| 3| 3| 4|             
                                           | 3| 6| 3| 8| 3| 6| 0| 6| 3| 1| 7| 3| 3| 8| 6| 6| 3| 2| 6| 6| 3| 5| 3| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                    2     2  2     1           1  2           2  2  3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |    2                    3     3     4                 3     2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                            1        1           1  2                 3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       3  3                       3  3                       3  3        3|             
      Hyperplasia                          |                                                                         3|             
      Inflammation, Suppurative            |                                  3           3              3  3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         1                       2  4                    3|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                   4        4              4                              |             
      Interstitial Cell, Hyperplasia       |             3                                      2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                       +                                                |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +                 +                       +                     |             
      Iliac, Pigmentation                  |                                                                          |             
      Lumbar, Pigmentation                 |    2                                                                     |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  M  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 5| 6| 4| 6| 7| 7| 6| 7| 7| 7| 6| 4| 4| 7| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 5| 3| 8| 2| 5| 5| 1| 3| 9| 2| 3| 3| 2| 5| 5| 3| 7| 5| 5| 8| 6| 3| 3| 4|             
                                           | 3| 6| 3| 8| 3| 6| 0| 6| 3| 1| 7| 3| 3| 8| 6| 6| 3| 2| 6| 6| 3| 5| 3| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  3                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             | 3  3              3                 3           4  3                 4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                3         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                             X            |             
      Ulcer                                |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2        1           3                                 |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    3                                                  3        3        3|             
      Hyperplasia                          | 1                                                                        |             
      Inflammation, Suppurative            |    3  1        1                                      2                  |             
      Mineralization                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1  1     1  1  1     1        1     1  1  1  1     1  1  1  1  1      |             
      Infiltration Cellular, Histiocyte    |    1  1                 4                       3           1            |             
      Alveolar Epithelium, Hyperplasia     |                         4     3  1              3  1                     |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
      Pleura, Fibrosis                     |                                  2                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          2                                         2  2                  |             
      Hemorrhage                           |                                                                3         |             
      Inflammation, Chronic                |                                                       1                  |             
      Inflammation, Suppurative            |       2  2                                      3  2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 5| 6| 4| 6| 7| 7| 6| 7| 7| 7| 6| 4| 4| 7| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 5| 3| 8| 2| 5| 5| 1| 3| 9| 2| 3| 3| 2| 5| 5| 3| 7| 5| 5| 8| 6| 3| 3| 4|             
                                           | 3| 6| 3| 8| 3| 6| 0| 6| 3| 1| 7| 3| 3| 8| 6| 6| 3| 2| 6| 6| 3| 5| 3| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                               3                                          |             
      Nasopharyngeal Duct, Hyperplasia     |                                                 2                        |             
      Respiratory Epithelium, Hyperplasia  |       3  3                                      2  1  3                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Fibrosis        |                                              2                           |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Cataract                             |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                         +                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  2  3  3  4  2  3  2  4  3  2  2  3  2  1  1  4  4  1  1  2  4  4  3  2|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 5| 3| 9| 8| 3| 3| 4| 6| 7| 9| 2| 3| 3| 2| 7| 3| 9| 2| 6| 5|             
                                           | 3| 3| 3| 9| 3| 6| 3| 2| 5| 3| 3| 7| 0| 9| 3| 3| 3| 3| 7| 9| 3| 7| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Parasite Metazoan             |       X        X           X           X                 X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X  X     X  X  X     X  X  X     X  X  X  X  X  X        X|             
      Clear Cell Focus                     | X     X        X                                X                        |             
      Degeneration, Cystic                 |                                                 2     4        2         |             
      Eosinophilic Focus                   |       X                                X        X  X                     |             
      Hepatodiaphragmatic Nodule           |             X                                                            |             
      Mixed Cell Focus                     |       X     X     X                                      X               |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                       1              3  2|             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +           +     +     +                    +|             
      Hemorrhage                           |                                                    4                     |             
      Fat, Inflammation, Granulomatous     |                                        4                                 |             
      Fat, Necrosis                        |                            2                 3     3                    3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Acinus, Atrophy                      |          2  2     2     1              2  2  2     2  2  2     2        1|             
      Artery, Inflammation                 |       3           2                                                      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                 +                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Diverticulum                         |                                                                   4      |             
      Inflammation, Suppurative            |                                           3                              |             
      Ulcer                                |                                           3                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                            +                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2     2                                               2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 5| 3| 9| 8| 3| 3| 4| 6| 7| 9| 2| 3| 3| 2| 7| 3| 9| 2| 6| 5|             
                                           | 3| 3| 3| 9| 3| 6| 3| 2| 5| 3| 3| 7| 0| 9| 3| 3| 3| 3| 7| 9| 3| 7| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |          2  2        2                                         2         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  3  2     3                             4                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                            2                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                      X                       X         |             
      Pars Distalis, Hyperplasia           | 3                                               3           3            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2                 2                 4           3     2     4      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3                    3     3              3  3  3        3     3  3      |             
      Hyperplasia                          |                      3                          3                        |             
      Inflammation, Suppurative            |                         3                 3              3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2        2  3              3        2  2                    2   |             
      Epithelium, Hyperplasia              |                                                             1            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |             4                 4        4           4     4               |             
      Interstitial Cell, Hyperplasia       |                                  3                             2  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +        +  +        +           +  +                       +|             
      Iliac, Pigmentation                  |                                  2                                       |             
      Lumbar, Pigmentation                 |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                         3                                                |             
      Renal, Hemorrhage                    |          2                                                               |             
      Renal, Pigmentation                  |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 5| 3| 9| 8| 3| 3| 4| 6| 7| 9| 2| 3| 3| 2| 7| 3| 9| 2| 6| 5|             
                                           | 3| 3| 3| 9| 3| 6| 3| 2| 5| 3| 3| 7| 0| 9| 3| 3| 3| 3| 7| 9| 3| 7| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3                                                                  |             
      Developmental Malformation           |                                                 X           X            |             
      Fibrosis                             |                            3              4  4     4  4  4        2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         1                                                |             
      Hydrocephalus                        |                         2                                               2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                3     3        3                                   3      |             
      Hyperplasia                          |          1                                                     1         |             
      Inflammation, Suppurative            |                      3        2                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1  1  1  1  1  1  1     1  1                    1  1     1  1  1     1   |             
      Infiltration Cellular, Histiocyte    |          2        1                             1              2     2   |             
      Alveolar Epithelium, Hyperplasia     |                                  3        3        2           2         |             
      Alveolus, Inflammation, Chronic      |                               1                    2                     |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       2  2                       2                                2      |             
      Hemorrhage                           |                                                 3     3                  |             
      Inflammation, Chronic                |                                                                   3      |             
      Inflammation, Suppurative            |       1  4                       3     2     2                    2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 5| 3| 9| 8| 3| 3| 4| 6| 7| 9| 2| 3| 3| 2| 7| 3| 9| 2| 6| 5|             
                                           | 3| 3| 3| 9| 3| 6| 3| 2| 5| 3| 3| 7| 0| 9| 3| 3| 3| 3| 7| 9| 3| 7| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hypertrophy                     |    3                                   2                 2               |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                  3     1                          3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Fibrosis        |                                                                          |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  3  4  4  4  2  4  2  2  3  2  2  2  3  4  3  4  4  4  2  2  2  4  2  2|             
      Pelvis, Dilatation                   |          3                                                               |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |          3                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 6| 4| 5|                                                        |            |
                             DAY ON TEST   | 7| 7| 8| 9| 5| 8|                                                        |            |
                                           | 6| 2| 6| 2| 6| 8|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    400 PPM                                | 8| 8| 8| 9| 9| 9|                                                        |      L     |
                                           | 7| 8| 9| 0| 1| 2|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +                                                         |  53        |
      Lumen, Parasite Metazoan             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +                                                         |  54        |
      Lumen, Parasite Metazoan             |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +                                                         |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +                                                         |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  A  +  +                                                         |  52        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  A  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  56        |
      Basophilic Focus                     |          X  X  X                                                         |     38     |
      Clear Cell Focus                     |          X                                                               |      7     |
      Degeneration, Cystic                 |                                                                          |      4  2.5|
      Eosinophilic Focus                   | X                                                                        |     10     |
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Mixed Cell Focus                     |                                                                          |      5     |
      Thrombosis                           |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |    3                                                                     |      5  2.4|
      Hepatocyte, Necrosis                 |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  12        |
      Hemorrhage                           |                                                                          |      4  4.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      2  3.5|
      Fat, Necrosis                        |                                                                          |      8  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      2  3.0|
      Acinus, Atrophy                      | 2  2  2                                                                  |     31  2.0|
      Artery, Inflammation                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  55        |
      Acanthosis                           |    3           3                                                         |      4  2.8|
      Diverticulum                         |                                                                          |      2  3.5|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  55        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 6| 4| 5|                                                        |            |
                             DAY ON TEST   | 7| 7| 8| 9| 5| 8|                                                        |            |
                                           | 6| 2| 6| 2| 6| 8|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    400 PPM                                | 8| 8| 8| 9| 9| 9|                                                        |      L     |
                                           | 7| 8| 9| 0| 1| 2|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  56        |
      Cardiomyopathy                       |       2                                                                  |     11  2.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  56        |
      Vacuolization Cytoplasmic            |    2     2                                                               |      7  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia                          | 2                                                                        |     16  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  I  +                                                         |  54        |
      Cyst                                 |                X                                                         |      4     |
      Pars Distalis, Hyperplasia           |    3                                                                     |     10  2.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  56        |
      C-Cell, Hyperplasia                  | 1                                                                        |     12  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  56        |
      Ectasia                              |                                                                          |     16  3.0|
      Hyperplasia                          |                                                                          |      3  3.0|
      Inflammation, Suppurative            |       3                                                                  |      8  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  56        |
      Inflammation, Suppurative            |                3                                                         |     12  2.4|
      Epithelium, Hyperplasia              |          2                                                               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  56        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  56        |
      Germinal Epithelium, Atrophy         |    4                                                                     |      9  4.0|
      Interstitial Cell, Hyperplasia       |          3     2                                                         |      9  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 6| 4| 5|                                                        |            |
                             DAY ON TEST   | 7| 7| 8| 9| 5| 8|                                                        |            |
                                           | 6| 2| 6| 2| 6| 8|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    400 PPM                                | 8| 8| 8| 9| 9| 9|                                                        |      L     |
                                           | 7| 8| 9| 0| 1| 2|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |             +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  56        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |  13        |
      Iliac, Pigmentation                  |                                                                          |      1  2.0|
      Lumbar, Pigmentation                 |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M  +                                                         |  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  54        |
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  56        |
      Congestion                           |                                                                          |      1  3.0|
      Developmental Malformation           |                                                                          |      2     |
      Fibrosis                             |                3                                                         |     15  3.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  56        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  56        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  56        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |                                                                          |      4  1.8|
      Hydrocephalus                        |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  56        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05133-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            ACETONITRILE                                       Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:32:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 6| 4| 5|                                                        |            |
                             DAY ON TEST   | 7| 7| 8| 9| 5| 8|                                                        |            |
                                           | 6| 2| 6| 2| 6| 8|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    400 PPM                                | 8| 8| 8| 9| 9| 9|                                                        |      L     |
                                           | 7| 8| 9| 0| 1| 2|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body                         |    3                                                                     |      9  3.0|
      Hyperplasia                          |    2                                                                     |      4  1.3|
      Inflammation, Suppurative            |    3  3                                                                  |      8  2.3|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  56        |
      Hemorrhage                           |       1  1  1                                                            |     35  1.0|
      Infiltration Cellular, Histiocyte    |             1                                                            |     11  1.7|
      Alveolar Epithelium, Hyperplasia     |             2                                                            |     10  2.4|
      Alveolus, Inflammation, Chronic      |                                                                          |      2  1.5|
      Pleura, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  56        |
      Foreign Body                         |                                                                          |      7  2.0|
      Hemorrhage                           | 3              3                                                         |      5  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |     10  2.3|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hypertrophy                     |                                                                          |      3  2.3|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  3.0|
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      8  2.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  56        |
      Peritracheal Tissue, Fibrosis        |                                                                          |      1  2.0|
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   2        |
      Cataract                             | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  56        |
      Nephropathy, Chronic                 | 1  3  2  2  1  2                                                         |     56  2.7|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  56        |
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.