National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2934

TDMS Study 05133-03 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95       
EXPERIMENT: 05133 TEST: 03                                                                                     TIME: 06:28:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 242          
PATHOLOGIST: R. RENNE                                                                                          CAS: 75-05-8         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                       ACETONITRILE                                     DATE: 05/20/95      
EXPERIMENT: 05133 TEST: 03                                                                                     TIME: 06:28:15      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01ES55073                                ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 242         
PATHOLOGIST: R. RENNE                                                                                          CAS: 75-05-8        

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 56     UNCENSORED DEATHS 37     CENSORED DEATHS 8    TERMINAL 11        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      394   418   472   483   492   511   520   524   539   546                 |
 |      561   566   587   597   602   609   623   632   637   646                 |
 |      651   651   652   674   679   679   684   684   685   685                 |
 |      686   693   699   701   707   721   729                                   |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 55     UNCENSORED DEATHS 34     CENSORED DEATHS 8    TERMINAL 13        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      331   446   496   517   525   530   555   558   559   560                 |
 |      561   564   567   586   586   588   590   595   623   637                 |
 |      639   642   653   665   665   688   689   693   701   707                 |
 |      718   721   723   732                                                     |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 56     UNCENSORED DEATHS 39     CENSORED DEATHS 8    TERMINAL 9         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      371   395   442   480   483   497   507   525   539   560                 |
 |      561   573   583   587   593   597   601   618   622   629                 |
 |      637   642   644   653   660   665   666   673   674   684                 |
 |      684   691   698   700   705   707   707   709   719                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456                             |
 |                                                                                |
 ==================================================================================

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 400 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 56     UNCENSORED DEATHS 31     CENSORED DEATHS 8    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      483   485   547   560   567   576   586   588   588   597                 |
 |      623   628   632   641   649   650   652   665   672   672                 |
 |      679   679   691   692   692   693   716   723   727   727                 |
 |      727                                                                       |
 |  CENSORED DEATHS                                                               |
 |      456   456   456   456   456   456   456   456                             |
 |                                                                                |
 ==================================================================================

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0  96.4  92.2  81.8  69.2  52.4  23.1      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0 100.0  98.2  98.2  96.4  87.8  62.1  47.1  27.8      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0 100.0 100.0 100.0  96.4  90.4  82.0  65.2  46.3  18.9      |
 |           |                                                                    |
 |           |                                                                    |
 |400 PPM    |   100.0 100.0 100.0 100.0 100.0  95.8  95.8  79.2  62.5  35.4      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      100 PPM      200 PPM      400 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       23.1%        27.8%        18.9%        35.4%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.141N     P=0.746N     P=0.667      P=0.137N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       611.3        606.2        607.2        638.9    |
 |NATURAL DEATHS (C)      |       (14.5)       (15.2)       (14.5)       (12.1)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       613.0        614.3        605.8        641.4    |
 |(STANDARD ERROR)        |       (14.4)       (14.7)       (14.4)       (13.4)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 56     UNCENSORED DEATHS 24     CENSORED DEATHS 9    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      105   310   360   377   427   470   525   530   588   597                 |
 |      623   625   637   662   665   702   706   707   714   721                 |
 |      721   721   727   729                                                     |
 |  CENSORED DEATHS                                                               |
 |      331   457   457   457   457   457   457   457   457                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 56     UNCENSORED DEATHS 27     CENSORED DEATHS 8    TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      328   478   506   517   588   600   603   614   621   623                 |
 |      623   637   651   665   665   671   679   693   693   698                 |
 |      706   707   713   713   718   719   721                                   |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 56     UNCENSORED DEATHS 22     CENSORED DEATHS 8    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      292   376   469   485   534   555   566   566   567   588                 |
 |      597   623   625   651   651   665   671   671   685   693                 |
 |      719   727                                                                 |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457                             |
 |                                                                                |
 ==================================================================================

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 400 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 56     UNCENSORED DEATHS 19     CENSORED DEATHS 8    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      394   427   558   572   599   618   629   666   670   672                 |
 |      672   679   679   679   693   707   721   723   729                       |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457                             |
 |                                                                                |
 ==================================================================================

                                   ACETONITRILE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0  98.2  98.2  94.6  92.8  88.8  84.5  80.1  69.3  49.8      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0 100.0  98.2  98.2  96.1  91.9  85.7  69.0  43.9      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0 100.0 100.0  98.2  96.4  92.2  90.1  77.6  67.1  54.5      |
 |           |                                                                    |
 |           |                                                                    |
 |400 PPM    |   100.0 100.0 100.0 100.0  98.2  96.4  96.4  90.1  85.9  60.8      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      100 PPM      200 PPM      400 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       49.8%        43.9%        54.5%        60.8%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.166N     P=0.752      P=0.843N     P=0.290N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       581.2        635.2        589.8        636.2    |
 |NATURAL DEATHS (C)      |       (33.5)       (17.5)       (23.3)       (21.4)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       621.8        646.8        637.8        661.2    |
 |(STANDARD ERROR)        |       (20.1)       (14.7)       (16.1)       (14.6)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            ACETONITRILE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        100 PPM          = 2
                                                        200 PPM          = 3
                                                        400 PPM          = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                    2    3    1            4
      |                                                      2    3    1  1   2    1442
      |                                                                       3    1142  2     44
      |                                                                             1 1  2 2    44
   90 +                                                                             3 1 1  22    4 4
      |                                                                               3 1  12   2  44
      |                                                                                 3  1 1
      |                                                                                      11 3   4  4
   80 +                                                                                       1 21     4  4
      |                                                                                          33       44
P     |                                                                                          13 1      44
E     |                                                                                          2  1 31    44
R  70 +                                                                                               311    44
C     |                                                                                             2 2 1 1   44
E     |                                                                                                3  1 1  4 4
N     |                                                                                               2   2      44
T  60 +                                                                                                   231 1
      |                                                                                                     22    44
S     |                                                                                                       11   4 4
U     |                                                                                                      2 1 2 1
R  50 +                                                                                                        3 3
V     |                                                                                                          23  2
I     |                                                                                                           3114   44
V     |
A  40 +                                                                                                            332 2
L     |                                                                                                                2 2
      |                                                                                                             11    4 4
      |                                                                                                              111 22
   30 +                                                                                                               33  2 2
      |                                                                                                                1 1  2
      |                                                                                                                  1  1
      |                                                                                                                33   1
   20 +                                                                                                                 33  3
      |
      |
      |
   10 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 43 obs hidden.

                                                            ACETONITRILE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        100 PPM          = 2
                                                        200 PPM          = 3
                                                        400 PPM          = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                1                            3     2          4
      |                  1                            3   1 2    1 3   4   4      3 2           4
      |                                                          1 1              3 23  22      4 4
      |                                                            1       1         3   2   3    4 2  4
P  90 +                                                                    1       1       1 3  3   2  2  4
E     |                                                                                    11   33     22 44
R     |                                                                                     1       1   22 4      4
C     |                                                                                          3  1  1 22
E  80 +                                                                                             3  1  1
N     |                                                                                                3  112     44
T     |                                                                                                   311 2
      |                                                                                                    31 2  1 4 4
S  70 +                                                                                                       3  12  4 1
U     |                                                                                                          322   4 4
R     |                                                                                                            2 2   44
V     |                                                                                                           3 3  11 4 4
I  60 +                                                                                                             322 11  4
V     |                                                                                                              322 33
A     |                                                                                                                2211 3
L     |                                                                                                                   1 1
   50 +                                                                                                                 22  1
      |
      |                                                                                                                  2  2
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 24 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.