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TDMS Study 05134-02 Pathology Tables

NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08




       Facility:  Battelle Northwest

       Chemical CAS #:  106-99-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 6| 2| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 5| 5| 3| 8| 3| 3| 3| 3| 2| 8| 3| 3| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 8| 2| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |          X                                                               |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |    X           X  X           X                                   X     X|             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +              +                                +           +      |             
      Fat, Lymphoma Malignant Lymphocytic  |                                                                          |             
      Fat, Lymphoma Malignant Mixed        |                                                                          |             
      Fat, Sarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Acinus, Histiocytic Sarcoma          |                                                                          |             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Acinus, Lymphoma Malignant Mixed     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 6| 2| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 5| 5| 3| 8| 3| 3| 3| 3| 2| 8| 3| 3| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 8| 2| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Capsule, Adenoma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Pars Distalis, Adenoma               |                                        X     X           X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                          M               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
      Granulosa Cell Tumor Benign          |                                                                         X|             
      Hemangioma                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Thecoma Benign                       |             X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                      X                                                   |             
      Polyp Stromal                        |                                           X              X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                               X                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                      X                                                   |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 6| 2| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 5| 5| 3| 8| 3| 3| 3| 3| 2| 8| 3| 3| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 8| 2| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  M  M  I  +  M  M  M  M  +  +  M  M  +  +  +  +  +  M  +  M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X        X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                               X                 X                        |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X        X                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                                                 X                        |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
      Hemangiosarcoma, Metastatic, Spleen  |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                   X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 4| 4| 7| 2| 7| 7| 7| 7| 6| 2| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 5| 5| 3| 8| 3| 3| 3| 3| 2| 8| 3| 3| 5| 3|             
                                           | 7| 7| 7| 7| 7| 7| 7| 8| 2| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +           +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |          X  X     X              X  X                                   X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X        X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 5| 7| 4| 7| 7| 2| 7| 7| 4| 4| 7| 7| 4| 4| 7| 7| 2| 7|             
                             DAY ON TEST   | 7| 3| 3| 1| 5| 3| 3| 6| 3| 5| 3| 3| 8| 3| 3| 5| 5| 3| 3| 5| 5| 3| 3| 8| 0|             
                                           | 7| 7| 7| 4| 1| 7| 7| 0| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  A  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             | X  X                                                                     |             
      Hepatocellular Adenoma               |                               X                 X              X  X      |             
      Hepatocellular Adenoma, Multiple     |                                           X                              |             
      Histiocytic Sarcoma                  |          X                                                              X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +                    +                 +  +        +         |             
      Fat, Lymphoma Malignant Lymphocytic  |                                                                          |             
      Fat, Lymphoma Malignant Mixed        |                                                                          |             
      Fat, Sarcoma, Metastatic, Skin       | X                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Skin            | X                                                                        |             
      Acinus, Histiocytic Sarcoma          |                                                                         X|             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Acinus, Lymphoma Malignant Mixed     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 5| 7| 4| 7| 7| 2| 7| 7| 4| 4| 7| 7| 4| 4| 7| 7| 2| 7|             
                             DAY ON TEST   | 7| 3| 3| 1| 5| 3| 3| 6| 3| 5| 3| 3| 8| 3| 3| 5| 5| 3| 3| 5| 5| 3| 3| 8| 0|             
                                           | 7| 7| 7| 4| 1| 7| 7| 0| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Capsule, Adenoma                     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  +  +  +  +  +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Pars Distalis, Adenoma               | X                       X                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Hemangioma                           |                                                    X                     |             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Thecoma Benign                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Polyp Stromal                        |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 5| 7| 4| 7| 7| 2| 7| 7| 4| 4| 7| 7| 4| 4| 7| 7| 2| 7|             
                             DAY ON TEST   | 7| 3| 3| 1| 5| 3| 3| 6| 3| 5| 3| 3| 8| 3| 3| 5| 5| 3| 3| 5| 5| 3| 3| 8| 0|             
                                           | 7| 7| 7| 4| 1| 7| 7| 0| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  M  +  +  +  +  M  M  +  M  M  +  +  M  M  +  M  +  +  M  +  M  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                 X                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Sarcoma         | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X                                                     X         |             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 5| 7| 7| 5| 7| 4| 7| 7| 2| 7| 7| 4| 4| 7| 7| 4| 4| 7| 7| 2| 7|             
                             DAY ON TEST   | 7| 3| 3| 1| 5| 3| 3| 6| 3| 5| 3| 3| 8| 3| 3| 5| 5| 3| 3| 5| 5| 3| 3| 8| 0|             
                                           | 7| 7| 7| 4| 1| 7| 7| 0| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Adenoma                              |    X                                               X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  I  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |          X                                                              X|             
      Lymphoma Malignant Lymphocytic       |                                                 X                        |             
      Lymphoma Malignant Mixed             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 7| 7| 2| 2| 7| 2| 6| 7| 4| 2| 2| 7| 7| 4| 6|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 5| 3| 3| 8| 8| 3| 8| 4| 3| 0| 8| 8| 3| 0| 8| 5|              |            |
                                           | 7| 3| 7| 7| 7| 7| 7| 2| 2| 7| 2| 4| 7| 1| 2| 2| 7| 8| 5| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  61        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  66        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |  66        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                   X                             X                        |          4 |
      Hepatocellular Adenoma               | X                                                                        |         11 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                       X                  |          3 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                               +                     |  12        |
      Fat, Lymphoma Malignant Lymphocytic  |    X                                                                     |          1 |
      Fat, Lymphoma Malignant Mixed        |                                                    X                     |          1 |
      Fat, Sarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Acinus, Histiocytic Sarcoma          |                                                       X                  |          2 |
      Acinus, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |    X                                                                     |          1 |
      Acinus, Lymphoma Malignant Mixed     |       X                                            X                     |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leiomyoma                            |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                     +  +                                 |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 7| 7| 2| 2| 7| 2| 6| 7| 4| 2| 2| 7| 7| 4| 6|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 5| 3| 3| 8| 8| 3| 8| 4| 3| 0| 8| 8| 3| 0| 8| 5|              |            |
                                           | 7| 3| 7| 7| 7| 7| 7| 2| 2| 7| 2| 4| 7| 1| 2| 2| 7| 8| 5| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Capsule, Adenoma                     |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  M  +  +  M  +  M  +  +  +  +  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Pars Distalis, Adenoma               |          X        X                                                      |          7 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Adenoma                              |                X                                                         |          2 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
      Thecoma Benign                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hemangioma                           |                                                                          |          1 |
      Polyp Stromal                        |                               X                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 7| 7| 2| 2| 7| 2| 6| 7| 4| 2| 2| 7| 7| 4| 6|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 5| 3| 3| 8| 8| 3| 8| 4| 3| 0| 8| 8| 3| 0| 8| 5|              |            |
                                           | 7| 3| 7| 7| 7| 7| 7| 2| 2| 7| 2| 4| 7| 1| 2| 2| 7| 8| 5| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
      Iliac, Lymphoma Malignant Lymphocytic|    X                                                                     |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |       X                                                                  |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +               |  58        |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  I  M  M  +  M  M  +  +  +  +  +               |  53        |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Lymphoma Malignant Mixed             |       X                                            X                     |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  M  +  M  +  M  M  M  +  +  +  +  +  +  M  +  +  +               |  39        |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Mixed             |       X                                            X                     |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +               |  66        |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  69        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 7| 7| 2| 2| 7| 2| 6| 7| 4| 2| 2| 7| 7| 4| 6|              |            |
                             DAY ON TEST   | 3| 2| 3| 3| 5| 3| 3| 8| 8| 3| 8| 4| 3| 0| 8| 8| 3| 0| 8| 5|              |            |
                                           | 7| 3| 7| 7| 7| 7| 7| 2| 2| 7| 2| 4| 7| 1| 2| 2| 7| 8| 5| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Alveolar/Bronchiolar Adenoma         | X                                                                        |          4 |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +  +  +               |  64        |
      Adenoma                              | X                                                        X               |         10 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Histiocytic Sarcoma                  |                                                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  67        |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Histiocytic Sarcoma                  |                                                       X                  |          3 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Mixed             |       X                                            X                     |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|             
                             DAY ON TEST   | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|             
                                           | 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  M  +     +  +  +     M  +     +  +  +     +  +  M  +  +        +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  A  +        A  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  A  +        A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  A  +        A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  A  +        A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  A  +        A  A|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  A  +        M  +|             
      Carcinoma                            |                               X                                          |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  A  +        A  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |                   X                                         X            |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +     +        +                 +                        |             
      Fat, Lymphoma Malignant Lymphocytic  |                                                                          |             
      Fat, Sarcoma, Metastatic, Uterus     |                X                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Acinus, Lymphoma Malignant Mixed     |                                                 X           X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  M        +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                            +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|             
                             DAY ON TEST   | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|             
                                           | 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  I|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  M  +     +  M  +     +  +     +  M  M     +  +  +  +  +        M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Pars Distalis, Adenoma               |    X  X                                   X        X        X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     A  +|             
      Adenoma                              |                                                       X                  |             
      Granular Cell Tumor Benign           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Adenocarcinoma                       |                                                                          |             
      Hemangioma                           |                                        X                                 |             
      Leiomyosarcoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |                                                 X                       X|             
      Sarcoma                              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Hemangioma                           |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        +  +|             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|             
                             DAY ON TEST   | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|             
                                           | 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                       X                  |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +  +  +     +  M  +     +  M     +  +  +     +  +  +  +  +        M  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +     +  +  +     +  +     +  M  M     +  +  +  +  M        +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  M  +     M  M  +     +  M     +  +  M     +  M  +  +  +        M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +     +  +  +     +  I     +  +  +     +  +  +  +  +        M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                          X  X        X            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Hemangioma                           |          X                                                               |             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X  X  X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +     +  +  +     +  +     +  +  M     +  +  +  +  +        +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X           X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  +  +     +  +  +     M  +     +  +  +     +  +  +  +  +        +  +|             
      Adenoacanthoma                       |                                        X                                 |             
      Adenocarcinoma                       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |          X                                                               |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        +  +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|             
                             DAY ON TEST   | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|             
                                           | 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                   X                                                      |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                X                       X              X  X               |             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +        M  +|             
      Adenocarcinoma                       |                   X                                                      |             
      Adenoma                              |                   X     X  X        X           X     X                  |             
      Bilateral, Adenoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +     +  +  +     +  +     +  +  +     +  +  +  +  +        A  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +     +  +  +     +  +     +  +  +     +  M  +  +  +        A  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 2| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 2| 7| 7| 7| 5| 7| 4| 2| 0| 7|             
                             DAY ON TEST   | 5| 3| 3| 7| 8| 3| 2| 3| 5| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 2| 3| 5| 8| 0| 3|             
                                           | 7| 5| 5| 2| 2| 5| 2| 5| 7| 5| 5| 7| 5| 2| 5| 2| 5| 5| 5| 4| 5| 7| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                          X  X  X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|             
                                           | 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6.25 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +        M  +     +  +  +  +  +  +  +     +        M  M  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  A        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  A        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +        I  +     +  +  +  +  +  +  +     +        +  +  +|             
      Adenoma                              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Carcinoma                            |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  A        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hepatocellular Carcinoma             |                X                             X                           |             
      Hepatocellular Carcinoma, Multiple   |                                                                         X|             
      Hepatocellular Adenoma               | X     X  X                                   X     X                     |             
      Hepatocellular Adenoma, Multiple     |             X                                                            |             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |    X                                X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                      +     +              +|             
      Fat, Lymphoma Malignant Lymphocytic  |                                                    X                     |             
      Fat, Sarcoma, Metastatic, Uterus     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Acinus, Lymphoma Malignant Mixed     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                   +     +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                         +                                                |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|             
                                           | 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6.25 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                         X|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Pars Distalis, Adenoma               |       X                 X        X        X                          X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                        M                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Granular Cell Tumor Benign           |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +  +     +  +  +|             
      Adenocarcinoma                       |                                                    X                     |             
      Hemangioma                           |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Polyp Stromal                        |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|             
                                           | 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6.25 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +     +  M        +  +     +  +  +  I  +  +  +     +        +  +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +        +  +     M  M  +  +  +  +  +     +        +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M     M  +        +  M     M  M  +  M  +  +  M     M        +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +        +  +     +  +  +  +  +  +  I     +        +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |    X                                                                     |             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |    X                                X                    X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  M        +  +     +  +  +  +  +  +  +     +        +  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +        +  +     +  +  +  +  +  +  M     +        +  +  +|             
      Adenoacanthoma                       |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |    X                                                                     |             
      Subcutaneous Tissue, Sarcoma         |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|             
                                           | 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6.25 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |    X                                                                     |             
      Adenocarcinoma, Multiple             |                                                                         X|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Adenocarcinoma, Metastatic, Uterus   |                                                    X                     |             
      Alveolar/Bronchiolar Adenoma         |                            X        X                    X        X      |             
      Alveolar/Bronchiolar Carcinoma       | X                                                                        |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                         X|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |    X                                                              X      |             
      Bilateral, Adenoma                   |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                         X|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |    X                                                     X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M     +  M        +  +     +  +  +  +  +  +  +     +        +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 4| 2| 2| 6| 7| 2| 7| 7| 6| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 5| 3| 6| 8| 8| 5| 3| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 5| 5| 3| 3| 9|             
                                           | 9| 5| 5| 7| 5| 7| 2| 2| 3| 5| 2| 5| 5| 2| 6| 6| 8| 6| 7| 6| 7| 7| 6| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6.25 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                X                    X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3|              |            |
                                           | 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +  +  M  +     +  +  +  +  M     +        +  M               |  41        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +     +  +  +  +     A  +  +  M  +     +        +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +     +  +  +  +     +  +  +  A  +     +        +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +     +  +  +  +     +  +  +  A  +     +        +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +     +  +  +  +     +  +  +  A  +     +        +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +     +  +  +  +     +  +  +  A  +     +        +  +               |  45        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +     +  +  +  +     A  +  +  A  +     +        +  +               |  46        |
      Carcinoma                            |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +     +  +  +  +     A  +  +  A  +     +        +  +               |  45        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  52        |
      Hepatocellular Carcinoma             |                      X           X  X                                    |          5 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                   X  X                       X                           |         10 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                X                                                         |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +     +                 +                          +               |  13        |
      Fat, Lymphoma Malignant Lymphocytic  |             X                 X                                          |          3 |
      Fat, Sarcoma, Metastatic, Uterus     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
      Acinus, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |             X                                                            |          1 |
      Acinus, Lymphoma Malignant Mixed     |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +     +  +  +  A  +     +        +  +               |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3|              |            |
                                           | 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +     M  +  +  +     M  +  M  +  +     +        +  M               |  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
      Pars Distalis, Adenoma               |                X                       X                                 |         12 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
      Follicular Cell, Adenoma             |                X                                                         |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +     +  +  +  +  +  +  +        +  +               |  59        |
      Adenoma                              |       X                                      X                           |          4 |
      Granular Cell Tumor Benign           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Leiomyosarcoma                       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3|              |            |
                                           | 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
      Iliac, Lymphoma Malignant Lymphocytic|             X                                                            |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Histiocytic Sarcoma           |                X                                                         |          1 |
      Renal, Lymphoma Malignant Lymphocytic|             X                                                            |          1 |
      Renal, Lymphoma Malignant Mixed      |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    M  +     +  M  +  +     +  +  +  +  M     +        +  +               |  42        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          2 |
      Lymphoma Malignant Mixed             |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    M  M     +  +  +  +     +  +  M  +  +     +        +  +               |  42        |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |             X                 X                                          |          3 |
      Lymphoma Malignant Mixed             |                            X                                             |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M  +     +  +  M  +     +  M  M  +  M     +        +  M               |  29        |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +     +  +  +  +     +  +  +  M  +     +        +  +               |  46        |
      Histiocytic Sarcoma                  |                X                                                         |          2 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                X                                                         |          2 |
      Lymphoma Malignant Lymphocytic       |             X                 X                                          |          3 |
      Lymphoma Malignant Mixed             |                            X                                             |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +     +  +  +  +     +  M  +  +  +     +        +  +               |  46        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          2 |
      Lymphoma Malignant Mixed             |                            X                                             |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3|              |            |
                                           | 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +     +  +  +  +     M  +  +  +  +     +        +  +               |  46        |
      Adenoacanthoma                       |                                                                          |          1 |
      Adenocarcinoma                       |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          2 |
      Subcutaneous Tissue, Sarcoma         |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +     +  +  +  +  +  +  +        +  +               |  60        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenocarcinoma, Multiple             |                                                                          |          1 |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                        X                                 |          1 |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                   X                    X              X                  |         11 |
      Alveolar/Bronchiolar Carcinoma       |                                                       X                  |          3 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                X                                                         |          2 |
      Lymphoma Malignant Lymphocytic       |             X                 X                                          |          3 |
      Lymphoma Malignant Mixed             |                            X                                             |          2 |
      Mediastinum, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 2| 6| 6| 7| 7| 2| 7| 7| 6| 6| 7| 4| 7| 2| 2| 7| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 9| 7| 3| 3| 8| 3| 3| 4| 4| 3| 5| 3| 8| 8| 3| 3|              |            |
                                           | 7| 6| 6| 2| 5| 3| 6| 6| 2| 0| 6| 4| 1| 6| 7| 6| 2| 2| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    6.25 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |       X                                               X                  |         10 |
      Bilateral, Adenoma                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  49        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                X                                                         |          2 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          2 |
      Lymphoma Malignant Mixed             |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +     +  +  +  +     +  +  +  +  +     +        +  +               |  46        |
      Histiocytic Sarcoma                  |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +  +  +     +  +  +  +  +  +  +        +  +               |  60        |
      Histiocytic Sarcoma                  |                X                                                         |          2 |
      Lymphoma Malignant Lymphocytic       |             X                 X                                          |          3 |
      Lymphoma Malignant Mixed             |                            X                                             |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|             
                                           | 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +     +  +           +     +  M  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +        A  +     +  +           +     A  +  +  A  +     +  A  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        A  +     +  +           +     A  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        A  +     +  +           +     A  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        A  +     +  +           +     A  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        A  +     +  +           +     A  +  +  +  +     +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        A  +     +  +           +     A  +  +  +  +     +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +     +  +           +     +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Parathyroid   |                                                                          |             
          Gland                            |                                                                          |             
      Hepatocellular Carcinoma             |                                                                X     X  X|             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |    X                                                                     |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                X        X              X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
      Lymphoma Malignant Mixed             |                                                                X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +              +                       +                     |             
      Fat, Histiocytic Sarcoma             |                                                                          |             
      Fat, Lymphoma Malignant Lymphocytic  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                          X        X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +     +  +           +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  A  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Pericardium, Leiomyosarcoma,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|             
                                           | 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Metastatic, Uterus               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M        +  +     M  +           M     M  +  +  +  +     +  M  M  M|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Adenoma               |    X                       X                    X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Carcinoma, Metastatic, Parathyroid   |                                                                          |             
          Gland                            |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Granulosa Cell Tumor Benign          |                X                                                         |             
      Histiocytic Sarcoma                  |                X                       X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Leiomyosarcoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Iliac, Histiocytic Sarcoma           |                X                                                         |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|             
                                           | 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Histiocytic Sarcoma           |                   X                    X                                 |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +        M  +     M  +           +     +  +  +  +  M     M  +  +  +|             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        +  +     +  +           +     +  +  +  +  +     +  M  M  +|             
      Histiocytic Sarcoma                  |                   X                    X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Sarcoma, Metastatic, Skin            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +        A  +     +  +           M     +  M  +  M  M     M  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                      X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Histiocytic Sarcoma                  |                   X     X              X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Histiocytic Sarcoma                  |                   X     X              X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
      Lymphoma Malignant Mixed             |                                                                X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        M  +     M  +           +     +  +  +  +  +     +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +        +  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Adenoacanthoma                       |                                                                          |             
      Adenocarcinoma                       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                      X   |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +     +  +           +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|             
                                           | 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma, Metastatic, Lung     |                                                                      X   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Histiocytic Sarcoma                  |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                X     X   |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                 X                 X  X  X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                            X                 X  X                    X   |             
      Carcinoma, Metastatic, Parathyroid   |                                                                          |             
          Gland                            |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                X     X  X|             
      Histiocytic Sarcoma                  |                         X              X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
      Fat, Mediastinum, Hemangioma         |                                                                          |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                                                X     X   |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
      Mediastinum, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                                                      X   |             
      Mediastinum, Leiomyosarcoma,         |                                                                          |             
          Metastatic, Uterus               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        A  +     +  +           +     A  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        A  +     +  +           +     A  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                A                                                         |             
                                            __________________________________________________________________________|             
   Eye                                     |                         M                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M        +  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 4| 4| 6| 7| 2| 6| 7| 4| 2| 2| 6| 4| 5| 7| 7| 6| 5| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 9| 5| 5| 7| 3| 8| 8| 3| 5| 8| 8| 9| 5| 0| 3| 3| 5| 3| 5| 3| 9| 3| 5|             
                                           | 4| 5| 4| 7| 7| 7| 4| 2| 1| 4| 7| 2| 2| 7| 7| 7| 4| 4| 0| 3| 7| 4| 1| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                      X   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                              X                           |             
      Carcinoma, Metastatic, Parathyroid   |                                                                          |             
          Gland                            |                                                                          |             
      Histiocytic Sarcoma                  |                         X              X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        A  +     +  +           +     +  +  +  +  +     +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X  X     X              X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                          X        X      |             
      Lymphoma Malignant Mixed             |                                                                X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|             
                                           | 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    20 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  +     +  +        +  +  A  A  +           +     +  +  +  A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +     +  +        +  +  +  +  A           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +     +  +        +  +  +  +  A           +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +     +  +        +  +  +  +  A           +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +     +  +        +  +  +  A  A           +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Carcinoma, Metastatic, Parathyroid   |                                                                          |             
          Gland                            |                                                                X         |             
      Hepatocellular Carcinoma             |                                                       X                  |             
      Hepatocellular Carcinoma, Multiple   |                                                                      X   |             
      Hepatocellular Adenoma               |                   X                       X           X                  |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                  X     X                                 |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +           +  +                                   +|             
      Fat, Histiocytic Sarcoma             |                                  X                                       |             
      Fat, Lymphoma Malignant Lymphocytic  |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +           +     +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +           +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Pericardium, Leiomyosarcoma,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|             
                                           | 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    20 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Metastatic, Uterus               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     M  +     +  +        M  +  +  +  +           M     +  +  +  M  +|             
      Carcinoma                            |                                                                X         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X                                                              X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Carcinoma, Metastatic, Parathyroid   |                                                                          |             
          Gland                            |                                                                X         |             
      Follicular Cell, Adenoma             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +           +     +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                     X                                    |             
      Iliac, Histiocytic Sarcoma           |                                                                          |             
      Iliac, Lymphoma Malignant Lymphocytic|                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|             
                                           | 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    20 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X     X                                 |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +     +  +        +  +  +  +  M           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  M     +  +        +  +  +  +  M           +     +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Lymphoma Malignant Lymphocytic       |                   X                 X                                    |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             | X                                                                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                 X                                    |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Adenoacanthoma                       | X                                                                        |             
      Adenocarcinoma                       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                   X      |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |          X                                                               |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|             
                                           | 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    20 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +           +     +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                               X                                          |             
      Alveolar/Bronchiolar Adenoma         | X                                      X                    X            |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                   X                                               X      |             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Carcinoma, Metastatic, Parathyroid   |                                                                          |             
          Gland                            |                                                                X         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                      X   |             
      Histiocytic Sarcoma                  |                                  X     X                                 |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
      Fat, Mediastinum, Hemangioma         |                                                                          |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Skin                 |                                                                   X      |             
      Mediastinum, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                                                          |             
      Mediastinum, Leiomyosarcoma,         |                                                                          |             
          Metastatic, Uterus               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Adenocarcinoma                       |                               X                                          |             
      Adenoma                              | X     X  X        X                                   X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 5| 7| 4| 7| 7| 2| 4| 5| 5| 5| 4| 3| 2| 2| 2| 6| 2| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 5| 5| 6| 3| 5| 3| 3| 8| 5| 4| 7| 4| 9| 6| 8| 8| 8| 0| 8| 3| 8| 3| 7| 3|             
                                           | 4| 7| 7| 9| 4| 7| 4| 4| 2| 7| 1| 3| 1| 2| 5| 2| 2| 2| 0| 2| 4| 1| 4| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    20 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Carcinoma, Metastatic, Parathyroid   |                                                                          |             
          Gland                            |                                                                X         |             
      Histiocytic Sarcoma                  |                                  X     X                                 |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +     +  +        +  +  +  +  +           +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +           +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X     X                                 |             
      Lymphoma Malignant Lymphocytic       |                   X                 X                                    |             
      Lymphoma Malignant Mixed             | X                                                                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5|              |            |
                                           | 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +     M  +  M  +  +     +                  |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  41        |
      Lymphoma Malignant Lymphocytic       |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  44        |
      Lymphoma Malignant Lymphocytic       |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  51        |
      Carcinoma, Metastatic, Parathyroid   |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hepatocellular Carcinoma             |          X                    X     X                                    |          7 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |       X           X                 X     X                              |          8 |
      Hepatocellular Adenoma, Multiple     |                                                       X                  |          1 |
      Histiocytic Sarcoma                  |                                        X                                 |          6 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +     +           +           +  +              +               |  16        |
      Fat, Histiocytic Sarcoma             |                                        X                                 |          2 |
      Fat, Lymphoma Malignant Lymphocytic  |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  47        |
      Acinus, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +     +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  A  +  +  +  +  M  +     +  +               |  57        |
      Squamous Cell Carcinoma              |    X                                                                     |          1 |
      Squamous Cell Papilloma              |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +     +  +               |  58        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5|              |            |
                                           | 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  50        |
      Histiocytic Sarcoma                  |                                        X                                 |          2 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          2 |
      Pericardium, Leiomyosarcoma,         |                                                                          |            |
          Metastatic, Uterus               |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  A     +  +  +  +  +     +                  |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  A     +  +  +  +  +     +                  |  48        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  47        |
      Pheochromocytoma Malignant           |                      X                                                   |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  A     +  +  +  A  +     +                  |  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M     +  +  M  +  M  +     +  +  M  +  +     +                  |  33        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  I  +  +     +  M  +  +  +     +                  |  48        |
      Pars Distalis, Adenoma               |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  49        |
      Carcinoma, Metastatic, Parathyroid   |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  +  +  A  +  +  +  +  A  +     +  +               |  58        |
      Adenoma                              |                                                 X                        |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +               |  60        |
      Histiocytic Sarcoma                  |                                        X                                 |          2 |
      Leiomyosarcoma                       |                         X                                                |          1 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5|              |            |
                                           | 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  A     +  +  +  +  +     +                  |  48        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  50        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Iliac, Histiocytic Sarcoma           |                                                                          |          1 |
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Histiocytic Sarcoma           |                                                                          |          2 |
      Renal, Lymphoma Malignant Lymphocytic|                                                 X                        |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M     +  +  +  +  +  +     +  M  +  M  +     +                  |  42        |
      Histiocytic Sarcoma                  |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       |                                                 X                        |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +     +  +  M  +  +     +                  |  46        |
      Histiocytic Sarcoma                  |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  +  M     +  +  M  +  M  +     +  +  +  +  M     M                  |  33        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  A     +  +  +  +  +     +                  |  48        |
      Histiocytic Sarcoma                  |                                        X                                 |          5 |
      Lymphoma Malignant Lymphocytic       |                                                 X                        |          4 |
      Lymphoma Malignant Mixed             |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  A     +  +  +  +  +     +                  |  48        |
      Histiocytic Sarcoma                  |                                                                          |          4 |
      Lymphoma Malignant Lymphocytic       |                            X                    X                        |          5 |
      Lymphoma Malignant Mixed             |                                           X                              |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  +  +  A     +  I  +  +  +     +                  |  45        |
      Lymphoma Malignant Lymphocytic       |                            X                    X                        |          6 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5|              |            |
                                           | 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  A     +  +  +  +  +     +                  |  49        |
      Adenoacanthoma                       |          X                                                               |          2 |
      Adenocarcinoma                       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  50        |
      Subcutaneous Tissue, Hemangioma      |                      X                                                   |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          2 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         | X                                                                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  50        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +               |  60        |
      Adenocarcinoma                       |                                                                          |          2 |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                     X  X                                 |          9 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                   X                                                      |          3 |
      Alveolar/Bronchiolar Carcinoma       |                   X  X              X     X           X                  |         10 |
      Carcinoma, Metastatic, Parathyroid   |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                     X                                    |          5 |
      Histiocytic Sarcoma                  |                                        X                                 |          5 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 2| 7| 7| 7| 6| 7| 6| 4| 7| 6| 7| 2| 7| 2| 7| 4|              |            |
                             DAY ON TEST   | 5| 3| 3| 8| 8| 3| 3| 3| 2| 3| 4| 5| 3| 0| 3| 7| 3| 8| 3| 5|              |            |
                                           | 3| 4| 4| 6| 2| 4| 4| 4| 5| 4| 9| 7| 4| 4| 4| 2| 4| 2| 4| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    20 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                      X                                                   |          1 |
      Fat, Mediastinum, Hemangioma         |                      X                                                   |          1 |
      Mediastinum, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          2 |
      Mediastinum, Hemangiosarcoma,        |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
      Mediastinum, Hepatocellular          |                                                                          |            |
          Carcinoma, Metastatic, Liver     |                                                                          |          1 |
      Mediastinum, Leiomyosarcoma,         |                                                                          |            |
          Metastatic, Uterus               |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +     +                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +     +  +  +  +  +  +     +  +  +  M  +     +                  |  49        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                                           X                              |          7 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  A     +  +  +  +  +     +                  |  48        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Carcinoma, Metastatic, Parathyroid   |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                        X                                 |          5 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  A     +  +  +  +  +     +                  |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +               |  60        |
      Histiocytic Sarcoma                  |                                        X                                 |          7 |
      Lymphoma Malignant Lymphocytic       |                            X                    X                        |          6 |
      Lymphoma Malignant Mixed             |                   X                       X                              |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|             
                                           | 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M           +  +           +  +           +  M     +  +     +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +           +  +           +  +           +  +     A  +     +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +  +        +  +  +           +  +     A  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
      Carcinoma, Multiple                  |                               X                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           A  +        +  +  +           +  +     A  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +     +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                   X      |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                           X                              |             
      Hepatocellular Adenoma, Multiple     | X                                                                 X      |             
      Histiocytic Sarcoma                  |                X                                                         |             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant                   |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                            X                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                           +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Fat, Leiomyosarcoma, Metastatic,     |                                                                          |             
           Intestine Small                 |                                                                          |             
      Fat, Sarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
      Acinus, Carcinoma, Metastatic, Ovary |                                                                          |             
      Acinus, Hemangioma                   |                                                                          |             
      Acinus, Histiocytic Sarcoma          |                                                                          |             
      Acinus, Leiomyosarcoma, Metastatic,  |                                                                          |             
           Intestine Small                 |                                                                          |             
      Acinus, Sarcoma, Metastatic, Skin    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +           +  +           +  +     +  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|             
                                           | 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +        +  +  +  +  +     +  +  +  +  +     +  +  +  A  +|             
      Hemangiosarcoma                      |                                                    X                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +           +  +           +  +           +  +     +  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +           +  +           +  +           +  +     +  +     +  +  +  A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
      Adenoma                              |             X                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +  +           +  +           +  +     M  +     M  +  M  A  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +           +  +           +  +     I  +     +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Pars Distalis, Adenoma               |                            X                                   X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +           +  +           +  +           +  +     +  +     +  +  +  A  +|             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
      Lymphoma Malignant                   |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X                                         X     X|             
      Carcinoma                            |                                                                          |             
      Granulosa Cell Tumor Malignant       |                                                                          |             
      Granulosa Cell Tumor Benign          |                               X                    X                     |             
      Hemangioma                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small                  |                                                                          |             
      Luteoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|             
                                           | 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                      X   |             
      Mixed Tumor Benign                   |                            X                          X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Adenocarcinoma                       |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyoma                            |                                                                X         |             
      Polyp Stromal                        |       X                                                     X            |             
      Sarcoma Stromal                      |                                                                          |             
      Cervix, Hemangiosarcoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +        +  +  +  +  +     +  +  +  +  +     +  +  +  A  +|             
      Hemangiosarcoma, Metastatic, Skin    |                                                                   X      |             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +        +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     M  +  +  M        M  +  M  +  M     +  +  M  +  +     +  M  M  +  +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   |                                                    X                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                      X   |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +        +  +  +  +  +     +  +  M  +  +     +  M  +  A  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M     +  +  +  +        +  M  +  +  +     +  +  +  M  M     M  +  +  A  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                              X                           |             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +        +  +  +  +  +     +  +  +  A  +     +  M  +  +  +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Histiocytic Sarcoma                  |                X                                                         |             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant                   |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|             
                                           | 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +        +  +  +  +  +     +  +  +  A  +     +  +  +  A  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                            X                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +        +  M  +  +  +     +  +  +  +  +     +  +  M  A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma                       |                                                                          |             
      Adenocarcinoma                       |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +  +           +  +     +     +  +  +  +  +     +  +  +  +  +|             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Multiple                        |                                                                   X      |             
      Subcutaneous Tissue, Sarcoma         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +           +  +           +  +     +  +     +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Skin    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Leiomyosarcoma,           |                                                                          |             
          Metastatic, Intestine Small      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +           +  +           +  +     +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +           +  +           +  +           +  +     +  +     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                            X                                             |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                             X            |             
      Alveolar/Bronchiolar Adenoma         | X     X                       X     X              X        X  X         |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 4| 4| 5| 5| 2| 2| 4| 7| 6| 4| 4| 2| 4| 5| 4| 6| 6| 2| 5| 6| 6| 5| 7|             
                             DAY ON TEST   | 3| 8| 5| 5| 7| 4| 8| 8| 5| 3| 5| 5| 5| 8| 8| 3| 5| 4| 6| 8| 8| 5| 6| 3| 3|             
                                           | 3| 2| 7| 7| 0| 4| 2| 2| 7| 3| 3| 7| 7| 2| 5| 2| 7| 9| 4| 2| 6| 0| 5| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       | X                                            X                           |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Granulosa Cell Tumor Malignant,      |                                                                          |             
          Metastatic, Ovary                |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant                   |                                                                      X   |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                              X                           |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Heart                |                                                    X                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +           +  +           +  +           +  +     +  +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +           +  +           +  +           +  +     +  +     +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +  +  +  +        +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|             
      Adenoma                              | X           X  X        X  X                 X     X                     |             
      Bilateral, Adenoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +           +  +           +  +           +  +     +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +  +           +  +           +  +     A  +     +  +  +  A  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                X                                                         |             
      Lymphoma Malignant                   |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|             
                             DAY ON TEST   | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|             
                                           | 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  A  +  +  +     +  +  I     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Carcinoma, Multiple                  |                                                                          |             
      Leiomyosarcoma                       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Hepatocellular Carcinoma             |             X     X           X  X                                   X  X|             
      Hepatocellular Adenoma               |       X  X        X           X                                          |             
      Hepatocellular Adenoma, Multiple     |    X                                                                 X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small                  |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +                 +  +  +                                    |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Fat, Leiomyosarcoma, Metastatic,     |                                                                          |             
           Intestine Small                 |                                     X                                    |             
      Fat, Sarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Acinus, Carcinoma, Metastatic, Ovary |                                                                          |             
      Acinus, Hemangioma                   |                                                                          |             
      Acinus, Histiocytic Sarcoma          | X                                                                        |             
      Acinus, Leiomyosarcoma, Metastatic,  |                                                                          |             
           Intestine Small                 |                                     X                                    |             
      Acinus, Sarcoma, Metastatic, Skin    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|             
                             DAY ON TEST   | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|             
                                           | 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | I  +  +  I  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  I  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  +     +  +  +     +  +        +     M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Granulosa Cell Tumor Malignant       | X     X                 X                                                |             
      Granulosa Cell Tumor Benign          |    X                                            X              X         |             
      Hemangioma                           |                X                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small                  |                                     X                                    |             
      Luteoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|             
                             DAY ON TEST   | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|             
                                           | 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Mixed Tumor Benign                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leiomyoma                            |                                                                          |             
      Polyp Stromal                        |                                                                          |             
      Sarcoma Stromal                      |                X                                                         |             
      Cervix, Hemangiosarcoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +                           |             
      Hemangiosarcoma                      |                                                                          |             
      Leiomyosarcoma                       |                                              X                           |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +|             
      Renal, Lymphoma Malignant Lymphocytic|                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  +  +  +  M  +     +  +  M  +  M  +  M     +     +  +  +  +  M|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  M     +     +  +  +  +  I|             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  M  M  +     +  +  +  M  +  +  M     +     +  M  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyosarcoma, Metastatic,          |                                                                          |             
          Intestine Small                  |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|             
                             DAY ON TEST   | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|             
                                           | 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  M  M|             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +|             
      Adenoacanthoma                       | X     X                                   X                              |             
      Adenocarcinoma                       |                      X                                      X  X         |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Multiple                        |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |          X                                                              X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
      Diaphragm, Leiomyosarcoma,           |                                                                          |             
          Metastatic, Intestine Small      |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  I     +  +  +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                         X|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         | X                    X                    X                    X     X   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 6| 6| 6| 6| 7| 2| 7| 5| 4| 4| 7| 4| 4| 2| 4| 2| 3| 6| 4| 6| 6|             
                             DAY ON TEST   | 2| 7| 4| 9| 1| 3| 8| 2| 3| 8| 3| 4| 1| 5| 3| 8| 5| 8| 0| 8| 9| 0| 4| 5| 2|             
                                           | 2| 0| 5| 8| 0| 9| 0| 5| 3| 2| 3| 6| 8| 7| 3| 5| 7| 2| 7| 2| 2| 8| 3| 8| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                         X        X                                       |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |       X                                                              X   |             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Granulosa Cell Tumor Malignant,      |                                                                          |             
          Metastatic, Ovary                | X                                                                        |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                      X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Skin            |          X                                                               |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                                                         X|             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Heart                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +  +  +  +  +|             
      Adenoma                              |    X           X  X           X                                      X   |             
      Bilateral, Adenoma                   |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  I  +  +  +     +  +  +     +  +        +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3|              |            |
                                           | 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +     +  +  +     +  +  M  +  +        +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +     +  +  +     A  +  +  M  +        +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +     +  +  +  A  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +     +  +  +  A  +        +  +  +               |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +     +  +  +  A  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +     +  +  +  A  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  +  +     +  +  +  A  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +     +  +  +  A  +        +  +  +               |  46        |
      Carcinoma, Multiple                  |                                                                          |          1 |
      Leiomyosarcoma                       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +     +  +  +  A  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +     +  +  +  A  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +               |  61        |
      Hemangiosarcoma                      |                                                       X                  |          1 |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Hepatocellular Carcinoma             |       X     X                          X                                 |          9 |
      Hepatocellular Adenoma               |                                  X     X        X  X  X                  |         10 |
      Hepatocellular Adenoma, Multiple     |                                                          X               |          5 |
      Histiocytic Sarcoma                  |                               X           X                              |          3 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                       +                              |   9        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Fat, Leiomyosarcoma, Metastatic,     |                                                                          |            |
           Intestine Small                 |                                                                          |          1 |
      Fat, Sarcoma, Metastatic, Skin       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  48        |
      Acinus, Carcinoma, Metastatic, Ovary |                      X                                                   |          1 |
      Acinus, Hemangioma                   |                                           X                              |          1 |
      Acinus, Histiocytic Sarcoma          |                                           X                              |          2 |
      Acinus, Leiomyosarcoma, Metastatic,  |                                                                          |            |
           Intestine Small                 |                                                                          |          1 |
      Acinus, Sarcoma, Metastatic, Skin    |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3|              |            |
                                           | 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
      Squamous Cell Carcinoma              | X                                                                        |          1 |
      Squamous Cell Papilloma              |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  | +                                                                        |   1        |
      Squamous Cell Carcinoma              | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                           X                              |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  I     +  +  +  +  +        +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  47        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +     +  +  +     +  +  +  M  M        +  +  +               |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +     +  +  +  M  +        +  +  +               |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Pars Distalis, Adenoma               |          X                                         X                     |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Follicular Cell, Adenoma             |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3|              |            |
                                           | 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                      X                                                   |          1 |
      Granulosa Cell Tumor Malignant       |                                                                          |          3 |
      Granulosa Cell Tumor Benign          |                                           X              X               |          7 |
      Hemangioma                           |          X                                                               |          2 |
      Histiocytic Sarcoma                  |                               X           X                              |          2 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small                  |                                                                          |          1 |
      Luteoma                              |                         X                                                |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Mixed Tumor Benign                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Adenocarcinoma                       |       X                                               X                  |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leiomyoma                            |                                                                          |          1 |
      Polyp Stromal                        |                                              X                           |          3 |
      Sarcoma Stromal                      |                                                                          |          1 |
      Cervix, Hemangiosarcoma              |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                               +                     |   3        |
      Hemangiosarcoma                      |                                                    X                     |          1 |
      Leiomyosarcoma                       |                                                                          |          1 |
      Squamous Cell Carcinoma              |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +     +  +  +     +  +  +  M  +  M  M  +  +  +               |  41        |
      Carcinoma, Metastatic, Ovary         |                      X                                                   |          1 |
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                           X                              |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Sarcoma, Metastatic, Skin            |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3|              |            |
                                           | 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +     +  M  +     +  M  +  M  +  M  M  +  +  +               |  49        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +     +  +  +     +  M  +  +  +  +  +  M  +  M               |  44        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Carcinoma, Metastatic, Ovary         |                      X                                                   |          1 |
      Histiocytic Sarcoma                  |                                           X                              |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
      Carcinoma, Metastatic, Ovary         |                      X                                                   |          1 |
      Histiocytic Sarcoma                  |                               X           X                              |          3 |
      Leiomyosarcoma, Metastatic,          |                                                                          |            |
          Intestine Small                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
      Histiocytic Sarcoma                  |                               X           X                              |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +     +  +  +     +  +  I  I  +  +  +  +  +  +               |  51        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +               |  61        |
      Adenoacanthoma                       |       X     X                    X                                       |          6 |
      Adenocarcinoma                       |    X     X                                                               |          6 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +     +  +  +  +  +  +     +  +  +               |  53        |
      Subcutaneous Tissue, Hemangioma      |                                  X                                       |          1 |
      Subcutaneous Tissue, Hemangiosarcoma | X                                                                        |          1 |
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |            |
           Multiple                        |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                   X              X                                       |          5 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3|              |            |
                                           | 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Diaphragm, Leiomyosarcoma,           |                                                                          |            |
          Metastatic, Intestine Small      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Histiocytic Sarcoma                  |                                           X                              |          2 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +     +  +  +     +  +  +  +  +        I  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Adenocarcinoma                       |                                                                          |          2 |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                      X  X     X        X                                 |         16 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                           X  X                           |          4 |
      Alveolar/Bronchiolar Carcinoma       |          X                                                               |          5 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Carcinoma, Metastatic, Ovary         |                      X                                                   |          1 |
      Granulosa Cell Tumor Malignant,      |                                                                          |            |
          Metastatic, Ovary                |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                        X                                 |          2 |
      Histiocytic Sarcoma                  |                               X           X                              |          3 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Mediastinum, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinum, Hemangiosarcoma,        |                                                                          |            |
          Metastatic, Heart                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 2| 5| 4| 7| 2| 5| 6| 3| 7| 6| 4| 4| 7| 7| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 9| 7| 8| 9| 4| 3| 8| 2| 5| 8| 0| 9| 5| 5| 3| 3| 3|              |            |
                                           | 3| 9| 3| 4| 9| 2| 7| 3| 3| 2| 4| 3| 7| 7| 8| 7| 7| 3| 3| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    62.5 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +        +  +     +  +  +  +  +  +  +  +  +  +               |  59        |
      Adenoma                              | X     X                                                                  |         14 |
      Bilateral, Adenoma                   |                                  X                                       |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Histiocytic Sarcoma                  |                                           X                              |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +     +  +  +  A  +        +  +  +               |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Histiocytic Sarcoma                  |                               X           X                              |          4 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|             
                             DAY ON TEST   | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|             
                                           | 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  A  +  +  +  +  +     +  +  A  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Granulocytic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Leiomyosarcoma, Metastatic, Stomach  |                   X                                                      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  A  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyosarcoma, Metastatic, Stomach  |                   X                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   |                                        X  X              X               |             
      Hepatocellular Carcinoma             | X                                                              X         |             
      Hepatocellular Carcinoma, Multiple   |                                        X                                 |             
      Hepatocellular Adenoma               |                                                             X           X|             
      Hepatocellular Adenoma, Multiple     |                                        X           X                     |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leiomyosarcoma, Metastatic, Stomach  |                   X                                                      |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +        +                    +              +         |             
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |             
           Heart                           |                                                 X                        |             
      Fat, Histiocytic Sarcoma             |                                                                          |             
      Fat, Leiomyosarcoma, Metastatic,     |                                                                          |             
           Stomach                         |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Acinus, Leiomyosarcoma, Metastatic,  |                                                                          |             
           Stomach                         |                   X                                                      |             
      Acinus, Leukemia Granulocytic        |                                                                          |             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                              X                    X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|             
                             DAY ON TEST   | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|             
                                           | 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Leiomyosarcoma                       |                   X                                                      |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |       X                       X                                          |             
      Squamous Cell Papilloma, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                X           X           X  X  X  X        X               |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Adenoma                              |                                                             X            |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leiomyosarcoma, Metastatic, Stomach  |                   X                                                      |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyosarcoma, Metastatic, Stomach  |                   X                                                      |             
      Leukemia Granulocytic                |                                                                          |             
      Pheochromocytoma Benign              |                                                                X         |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +  +  +  +     +  M  +  +  +  +     +  M  +  +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  I  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|             
                             DAY ON TEST   | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|             
                                           | 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Granulosa Cell Tumor Malignant       |                                                                X         |             
      Granulosa Cell Tumor Benign          |             X     X     X                                                |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leiomyosarcoma, Metastatic, Stomach  |                   X                                                      |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
      Mixed Tumor Benign                   | X              X              X                             X            |             
      Bilateral, Granulosa Cell Tumor      |                                                                          |             
          Benign                           |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Hemangioma                           |                                                                   X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                              X                    X      |             
      Axillary, Sarcoma, Metastatic, Skin  |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                              X                    X      |             
      Pancreatic, Histiocytic Sarcoma      |                                                                          |             
      Pancreatic, Leiomyosarcoma,          |                                                                          |             
          Metastatic, Stomach              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  M  M  M  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M|             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  I  +  +  M  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  I  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|             
                             DAY ON TEST   | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|             
                                           | 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leiomyosarcoma, Metastatic, Stomach  |                   X                                                      |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Adenoacanthoma                       |                                     X        X                           |             
      Adenocarcinoma                       | X     X        X     X  X  X                                             |             
      Adenocarcinoma, Multiple             |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Leiomyosarcoma, Metastatic, Stomach  |                   X                                                      |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                    X                     |             
      Subcutaneous Tissue, Sarcoma         |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Diaphragm, Sarcoma, Metastatic, Skin |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Hemangiosarcoma, Metastatic, Heart   |                                                 X                        |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|             
                             DAY ON TEST   | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|             
                                           | 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Multiple             |                                                                          |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                      X                                                   |             
      Alveolar/Bronchiolar Adenoma         |                                                                         X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                        X                    X            |             
      Alveolar/Bronchiolar Carcinoma       |                               X                             X  X        X|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                    X                     |             
      Granulosa Cell Tumor Malignant,      |                                                                          |             
          Metastatic, Ovary                |                                                                X         |             
      Hemangiosarcoma, Metastatic, Heart   |                                        X  X     X        X               |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                                      X                                 |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Heart                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |          X     X     X     X           X                 X  X     X     X|             
      Bilateral, Adenoma                   |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Hemangiosarcoma, Metastatic, Heart   |                                                 X                        |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leiomyosarcoma, Metastatic, Stomach  |                   X                                                      |             
      Leukemia Granulocytic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 2| 5| 4| 4| 4| 3| 4| 4| 4| 4| 2| 4| 6| 4| 5| 3| 5| 2| 4| 5| 5| 4| 2| 4|             
                             DAY ON TEST   | 6| 8| 0| 5| 5| 6| 9| 7| 5| 8| 5| 8| 5| 2| 6| 1| 7| 9| 8| 5| 9| 6| 1| 8| 5|             
                                           | 9| 2| 2| 7| 7| 0| 3| 1| 7| 5| 7| 2| 4| 9| 3| 3| 1| 7| 2| 7| 7| 9| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                    X      |             
      Lymphoma Malignant Mixed             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|             
                             DAY ON TEST   | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|             
                                           | 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    A  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  A     A  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     A  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  A     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  A     A  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  A  +  I  +  +  +  +  +  +  +  A     +  +   |             
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +   |             
      Histiocytic Sarcoma                  |                         X                                                |             
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   |    X     X        X           X                    X                     |             
      Hepatocellular Carcinoma             |    X  X        X  X                                                  X   |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |       X     X     X  X     X     X                                       |             
      Hepatocellular Adenoma, Multiple     |                X                                         X               |             
      Histiocytic Sarcoma                  |                         X  X        X                 X                  |             
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X           X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +  +  +        +           +  +           +  +               |             
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |             
           Heart                           |                                                                          |             
      Fat, Histiocytic Sarcoma             |                            X                          X                  |             
      Fat, Leiomyosarcoma, Metastatic,     |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +   |             
      Acinus, Leiomyosarcoma, Metastatic,  |                                                                          |             
           Stomach                         |                                                                          |             
      Acinus, Leukemia Granulocytic        |                                                                          |             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                              X                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|             
                             DAY ON TEST   | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|             
                                           | 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Carcinoma              |                         X                                                |             
      Squamous Cell Papilloma              |                X                                                         |             
      Squamous Cell Papilloma, Multiple    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |    X     X        X           X                    X  X           X  X   |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Adenoma                              |                               X                                          |             
      Histiocytic Sarcoma                  |                         X           X                                    |             
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Histiocytic Sarcoma                  |                         X                                                |             
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +   |             
      Adenoma                              |                      X                                            X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  M  +  +  +  +  M  M  +  +  M  +  +  +  M  M  +  +  +  M     +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +   |             
      Follicular Cell, Adenoma             |       X                                                           X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|             
                             DAY ON TEST   | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|             
                                           | 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Granulosa Cell Tumor Malignant       |             X                                                            |             
      Granulosa Cell Tumor Benign          |                X  X                                               X      |             
      Histiocytic Sarcoma                  |                            X                          X                  |             
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Mixed Tumor Benign                   |                         X                                         X      |             
      Bilateral, Granulosa Cell Tumor      |                                                                          |             
          Benign                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Hemangioma                           |                                                                          |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X           X                                    |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Axillary, Sarcoma, Metastatic, Skin  |                                                    X                     |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Histiocytic Sarcoma      |                                                                          |             
      Pancreatic, Leiomyosarcoma,          |                                                                          |             
          Metastatic, Stomach              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  M  +  I  +  M  +  +  +  +  +  M  M  +  +  M  +  +  M  M|             
      Adenocarcinoma, Metastatic, Lung     |       X                                                                  |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                            X        X                 X                  |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  M  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|             
                             DAY ON TEST   | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|             
                                           | 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                         X  X                                             |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X  X     X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X  X        X                 X                  |             
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X     X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X           X                 X                  |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X           X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X           X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A     +  +   |             
      Adenoacanthoma                       |                                                                          |             
      Adenocarcinoma                       |                      X                 X        X                    X   |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |             
      Sebaceous Gland, Adenoma             |                         X                                                |             
      Subcutaneous Tissue, Hemangiosarcoma |       X                                                                  |             
      Subcutaneous Tissue, Sarcoma         |                   X                                X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Diaphragm, Sarcoma, Metastatic, Skin |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
      Histiocytic Sarcoma                  |                                     X                 X                  |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|             
                             DAY ON TEST   | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|             
                                           | 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     A  +   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Multiple             |       X                                                                  |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                      X     X        X  X  X           X              X   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                X        X                                         X      |             
      Alveolar/Bronchiolar Carcinoma       |                            X                       X  X              X   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |          X        X  X           X                       X        X      |             
      Granulosa Cell Tumor Malignant,      |                                                                          |             
          Metastatic, Ovary                |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   |                   X                                                      |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                   X                                                      |             
      Histiocytic Sarcoma                  |                         X  X        X                 X                  |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Sarcoma, Metastatic, Skin            |                                                    X                     |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Heart                |    X                                                              X      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +   |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |       X        X                 X     X           X                     |             
      Bilateral, Adenoma                   |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +   |             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
      Histiocytic Sarcoma                  |                         X  X                          X                  |             
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |             
      Leukemia Granulocytic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 5| 5| 4| 4| 6| 5| 4| 4| 4| 3| 4| 4| 4| 2| 4| 5| 5| 6| 0| 2| 7| 5| 2|             
                             DAY ON TEST   | 8| 5| 6| 6| 5| 5| 6| 0| 7| 8| 6| 7| 0| 1| 5| 0| 5| 2| 3| 2| 0| 8| 0| 0| 8|             
                                           | 2| 3| 9| 9| 7| 7| 3| 2| 2| 5| 4| 3| 8| 8| 7| 5| 7| 4| 2| 4| 9| 2| 4| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Renal Tubule, Adenoma                |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +   |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X  X        X                 X                  |             
      Leukemia Granulocytic                |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X  X     X     X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3|              |            |
                             DAY ON TEST   | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4|              |            |
                                           | 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     A      |
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +     +  +  +  +  M     M  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +     +  +  +     +  A  +  +  +     +  A  +  A               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  +  +     +  A  +  +  +     +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +     M  A  +  +  +     +  A  +  +               |  53        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +     +  +  +     +  A  +  +  +     +  +  +  +               |  55        |
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  +  +  +     +  +  +     +  A  +  +  +     +  A  +  +               |  54        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  61        |
      Hemangiosarcoma, Multiple            |                                                    X                     |          1 |
      Hemangiosarcoma, Metastatic, Heart   | X                                X                                       |         10 |
      Hepatocellular Carcinoma             |                   X                                                      |          8 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                   X  X                                                   |         10 |
      Hepatocellular Adenoma, Multiple     |          X                                                               |          5 |
      Histiocytic Sarcoma                  |             X                                            X               |          7 |
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |          1 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                       X                  |          6 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +              +                                       |  15        |
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |            |
           Heart                           |                                  X                                       |          2 |
      Fat, Histiocytic Sarcoma             |                                                                          |          2 |
      Fat, Leiomyosarcoma, Metastatic,     |                                                                          |            |
           Stomach                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  59        |
      Acinus, Leiomyosarcoma, Metastatic,  |                                                                          |            |
           Stomach                         |                                                                          |          1 |
      Acinus, Leukemia Granulocytic        |    X                                                                     |          1 |
      Acinus, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                               X                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  72                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3|              |            |
                             DAY ON TEST   | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4|              |            |
                                           | 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     A      |
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |             X                                                            |          4 |
      Squamous Cell Papilloma, Multiple    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  68        |
      Lymphoma Malignant Lymphocytic       |                               X                       X                  |          4 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Hemangiosarcoma                      | X     X     X                 X  X        X        X                     |         22 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                       X                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
      Adenoma                              |                      X                                                   |          3 |
      Histiocytic Sarcoma                  |                                                                          |          3 |
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |          1 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          2 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |          1 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Pheochromocytoma Benign              |                                  X                                       |          2 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  59        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  I  +  +  M     +  +  +     +  +  M  +  +     +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  M               |  58        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  73                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3|              |            |
                             DAY ON TEST   | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4|              |            |
                                           | 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     A      |
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  59        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Adenoma                              |                                  X                                       |          1 |
      Granulosa Cell Tumor Malignant       |                   X                                                      |          3 |
      Granulosa Cell Tumor Benign          |                X        X                 X                              |          9 |
      Histiocytic Sarcoma                  |                                                                          |          3 |
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |          1 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          4 |
      Mixed Tumor Benign                   |                                                                          |          6 |
      Bilateral, Granulosa Cell Tumor      |                                                                          |            |
          Benign                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Adenocarcinoma                       |                   X                                                      |          1 |
      Hemangioma                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Polyp Stromal                        |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Histiocytic Sarcoma                  |             X                                            X               |          4 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                       X                  |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  69        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Axillary, Sarcoma, Metastatic, Skin  |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  74                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3|              |            |
                             DAY ON TEST   | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4|              |            |
                                           | 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     A      |
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Histiocytic Sarcoma      |             X                                                            |          1 |
      Pancreatic, Leiomyosarcoma,          |                                                                          |            |
          Metastatic, Stomach              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  M  +  +  M  +  +  M  M  +  +  +  M  +  +  +  +               |  46        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                     X                                    |          1 |
      Histiocytic Sarcoma                  |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       |                                                       X                  |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  M  +  +  M  I  M  +  +  +  M  +  +               |  54        |
      Histiocytic Sarcoma                  |                                                          X               |          2 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                       X                  |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  M  +  M  +  M               |  51        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                         X           X                                    |          2 |
      Histiocytic Sarcoma                  |                                                                          |          3 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                       X                  |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  66        |
      Histiocytic Sarcoma                  |                                                          X               |          6 |
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |          1 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                       X                  |          6 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Histiocytic Sarcoma                  |             X                                                            |          4 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                       X                  |          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  I  +  +  +               |  59        |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                X                  |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +     M  +  +  +  +     +  +  +  +               |  58        |
      Adenoacanthoma                       |       X                                X                                 |          4 |
      Adenocarcinoma                       |                      X                          X                        |         12 |
      Adenocarcinoma, Multiple             |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                       X                  |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  75                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3|              |            |
                             DAY ON TEST   | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4|              |            |
                                           | 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     A      |
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          2 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Diaphragm, Sarcoma, Metastatic, Skin |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
      Hemangiosarcoma, Metastatic, Heart   |                                  X                                       |          2 |
      Histiocytic Sarcoma                  |             X                                            X               |          4 |
      Lymphoma Malignant Lymphocytic       |                                                       X                  |          3 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Adenocarcinoma, Multiple             |                                                                          |          1 |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                   X                                                      |          1 |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |       X              X                                                   |          3 |
      Alveolar/Bronchiolar Adenoma         | X              X                          X  X  X                        |         13 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          5 |
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |          9 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                         X           X     X                              |         10 |
      Granulosa Cell Tumor Malignant,      |                                                                          |            |
          Metastatic, Ovary                |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Heart   | X                                                                        |          6 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          3 |
      Histiocytic Sarcoma                  |             X                                            X               |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  76                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 2| 6| 3| 4| 2| 3| 5| 5| 2| 5| 2| 4| 3| 3| 3|              |            |
                             DAY ON TEST   | 8| 3| 4| 5| 7| 8| 9| 7| 7| 8| 8| 4| 0| 6| 6| 8| 8| 4| 1| 4|              |            |
                                           | 4| 6| 6| 7| 0| 2| 5| 0| 8| 2| 6| 3| 9| 8| 9| 2| 9| 3| 7| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     A      |
    200 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                       X                  |          5 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                         X           X                                    |          2 |
      Mediastinum, Hemangiosarcoma,        |                                                                          |            |
          Metastatic, Heart                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +               |  60        |
      Adenocarcinoma                       |                   X                                                      |          1 |
      Adenoma                              | X                 X  X  X           X     X     X                        |         21 |
      Bilateral, Adenoma                   |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  60        |
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |          1 |
      Histiocytic Sarcoma                  |             X                                                            |          5 |
      Leiomyosarcoma, Metastatic, Stomach  |                                                                          |          1 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                       X                  |          5 |
      Renal Tubule, Adenoma                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +               |  59        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Histiocytic Sarcoma                  |             X                                            X               |          7 |
      Leukemia Granulocytic                |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                      X        X                       X                  |          9 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  77                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|             
                                           | 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  A  A  +  +  +  +  +  A  M  +  A  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   | X              X     X        X           X              X               |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Histiocytic Sarcoma                  |                            X                          X                  |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X  X                          X                          X  X|             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                   X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                   +        +      |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                   X      |             
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |             
           Heart                           |                      X                                                   |             
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |             
           Spleen                          |                                                                          |             
      Fat, Sarcoma, Metastatic, Stomach    |                                                          X               |             
      Fat, Squamous Cell Carcinoma,        |                                                                          |             
          Metastatic, Stomach              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Mammary Gland   |                                                                   X      |             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |    X           X                          X                             X|             
      Acinus, Squamous Cell Carcinoma,     |                                                                          |             
           Metastatic, Stomach             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|             
                                           | 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                X                          X                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |       X        X                          X                              |             
      Sarcoma                              |                                                          X               |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                   X      |             
      Squamous Cell Carcinoma              |                      X                                   X               |             
      Squamous Cell Papilloma              |                                           X        X                     |             
      Squamous Cell Papilloma, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X  X                                   X                              |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                   X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                                                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      | X              X     X        X           X  X     X     X               |             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |       X  X                                X                              |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |       X  X                                X                              |             
      Sarcoma, Metastatic, Stomach         |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                   X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  M  M  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|             
                                           | 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Granulosa Cell Tumor Benign          |                      X                             X              X      |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X                                                        X  X|             
      Mixed Tumor Benign                   |                         X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X                             X                          X   |             
      Polyp Stromal                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                          X                  |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X  X                          X                          X  X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                           X                          X   |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                      X   |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |    X                                                                     |             
      Renal, Lymphoma Malignant Lymphocytic|       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  M  +  M  +  +  +  M  +  +  +  M  M  M  M  M  M  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X                             X                          X  X|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  I  +  +  I  +  +  I  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X                             X                          X  X|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|             
                                           | 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |                                                                   X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X                             X                          X  X|             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Mammary Gland   |                                                             X            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  M  +  +  +|             
      Histiocytic Sarcoma                  |                            X                          X                  |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X                             X                          X  X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                            X                          X                  |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X  X                          X                          X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X  X                          X                          X  X|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       | X                       X           X              X                     |             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Mixed Tumor Malignant                |                                                             X            |             
      Sarcoma                              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Subcutaneous Tissue, Hemangiosarcoma |                         X                                                |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Metastatic, Heart               |                      X                                                   |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                    X                     |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Squamous Cell   |                                                                          |             
          Carcinoma, Metastatic, Stomach   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|             
                                           | 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |             
          Stomach                          |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X                          X  X|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                                     +  +|             
      Lymphoma Malignant Lymphocytic       |                X                                                     X  X|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                         X                                                |             
      Alveolar/Bronchiolar Adenoma         |             X        X  X     X     X              X     X               |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                   X      |             
      Alveolar/Bronchiolar Carcinoma       |                                              X              X     X      |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                    X                     |             
      Hemangiosarcoma, Metastatic, Heart   | X                    X        X           X              X               |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                            X                          X                  |             
      Lymphoma Malignant Lymphocytic       |       X  X                                X                          X   |             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Mammary Gland                   |                                                             X            |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                   X      |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Heart                |                                                                          |             
      Mediastinum, Mixed Tumor Malignant,  |                                                                          |             
           Metastatic, Mammary Gland       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 2| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 4| 3| 2| 3| 2| 2|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 8| 9| 2| 1| 1| 8| 3| 8| 2| 0| 8| 8| 1| 4| 7| 0| 8| 0| 8|             
                                           | 3| 0| 7| 4| 5| 7| 2| 8| 8| 7| 9| 2| 1| 0| 9| 7| 2| 7| 9| 3| 9| 5| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Mediastinum, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Stomach             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Adenoma                              |                      X                       X                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
      Histiocytic Sarcoma                  |                            X                          X                  |             
      Lymphoma Malignant Lymphocytic       |       X  X     X                          X                             X|             
      Lymphoma Malignant                   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                X                          X                              |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                          X                  |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X  X  X  X  X                          X                          X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|             
                             DAY ON TEST   | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|             
                                           | 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  I  A  +  +  I  +  +  +  A  +  A  +  +  A  +  A  A  A  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  A  A  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  A  M  +  +  A  +  A  +  A  +  A  +  +  A  +  +  A  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Hemangiosarcoma, Multiple            |          X                                                               |             
      Hemangiosarcoma, Metastatic, Heart   |                   X        X        X        X        X     X            |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                       X                  |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       | X                    X                 X        X  X     X        X  X  X|             
      Lymphoma Malignant                   |    X                                                                     |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |             
           Heart                           |                                                                          |             
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |             
           Spleen                          |                                                                          |             
      Fat, Sarcoma, Metastatic, Stomach    |                                                                          |             
      Fat, Squamous Cell Carcinoma,        |                                                                          |             
          Metastatic, Stomach              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                          X               |             
      Acinus, Squamous Cell Carcinoma,     |                                                                          |             
           Metastatic, Stomach             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|             
                             DAY ON TEST   | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|             
                                           | 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                 X        X               |             
      Sarcoma                              |                                                                          |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Squamous Cell Carcinoma              |                                                                         X|             
      Squamous Cell Papilloma              |                            X              X  X        X     X            |             
      Squamous Cell Papilloma, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                 X  X                     |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                   X        X     X  X        X        X     X            |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                    X  X              X           X              X  X  X|             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                          X  X                     |             
      Sarcoma, Metastatic, Stomach         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                      X                             X              X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|             
                             DAY ON TEST   | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|             
                                           | 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Granulosa Cell Tumor Benign          |                            X                                             |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X        X  X     X        X  X  X|             
      Mixed Tumor Benign                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                 X                        |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                    X  X              X        X  X     X        X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      | X                                               X        X               |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                 X                        |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                 X        X               |             
      Renal, Lymphoma Malignant Lymphocytic|                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                    X  X              X        X  X     X        X  X  X|             
      Lymphoma Malignant                   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  M  +  M  M  I  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                    X                 X        X  X     X        X      |             
      Lymphoma Malignant                   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|             
                             DAY ON TEST   | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|             
                                           | 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       | X                    X  X              X           X     X        X  X  X|             
      Lymphoma Malignant                   |    X                                                                     |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       | X                                      X        X  X     X        X  X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       | X                    X                          X  X     X        X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       | X                    X  X              X        X  X     X        X  X  X|             
      Lymphoma Malignant                   |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                         X                 X           X                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                 X                        |             
      Mixed Tumor Malignant                |                               X                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Metastatic, Heart               |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Squamous Cell   |                                                                          |             
          Carcinoma, Metastatic, Stomach   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|             
                             DAY ON TEST   | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|             
                                           | 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |             
          Stomach                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       | X                    X                                            X  X   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                               +                        |             
      Lymphoma Malignant Lymphocytic       | X                                               X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  A  +  +  +  +  +  I  +  +  +  +  I  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                         X                 X                              |             
      Alveolar/Bronchiolar Adenoma         |             X     X        X        X                 X     X            |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                                       X                  |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   |                   X                 X        X        X     X            |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       |                      X  X              X        X  X              X  X  X|             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Mammary Gland                   |                               X                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Heart                |                                                                          |             
      Mediastinum, Mixed Tumor Malignant,  |                                                                          |             
           Metastatic, Mammary Gland       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 1| 3| 3| 2| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2|             
                             DAY ON TEST   | 5| 8| 3| 2| 8| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7|             
                                           | 9| 9| 5| 5| 2| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Mediastinum, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Stomach             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         | I  I  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             
      Adenoma                              |                                                       X                  |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       |                      X  X              X        X  X              X  X  X|             
      Lymphoma Malignant                   |    X                                                                     |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                 X  X     X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant                   |    X                                                                     |             
      Lymphoma Malignant Lymphocytic       | X                    X  X              X        X  X     X        X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|             
                             DAY ON TEST   | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|             
                                           | 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  A  A  +  A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  A  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  A  +  +  A  A  +  A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  A  A  +  A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  A  +  A|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |             X                                                            |             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hemangiosarcoma, Metastatic, Heart   |             X                    X                                      X|             
      Hemangiosarcoma, Metastatic, Skin    |                                                       X                  |             
      Hepatocellular Carcinoma             |                                                                X         |             
      Hepatocellular Adenoma               |                                                                          |             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                           X              X               |             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                           +         |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |             
           Heart                           |                                                                          |             
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |             
           Spleen                          |                                                                X         |             
      Fat, Sarcoma, Metastatic, Stomach    |                                                                          |             
      Fat, Squamous Cell Carcinoma,        |                                                                          |             
          Metastatic, Stomach              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Acinus, Squamous Cell Carcinoma,     |                                                                          |             
           Metastatic, Stomach             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|             
                             DAY ON TEST   | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|             
                                           | 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma                              |                                                                          |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Squamous Cell Carcinoma              |                                                    X                     |             
      Squamous Cell Papilloma              |                X                 X        X           X                 X|             
      Squamous Cell Papilloma, Multiple    | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |             X                    X                 X                 X  X|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X           X                    X              X  X            |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |             X                                                            |             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                           X              X               |             
      Sarcoma, Metastatic, Stomach         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Lymphocytic       |                                           X              X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|             
                             DAY ON TEST   | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|             
                                           | 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Granulosa Cell Tumor Benign          |          X                                                               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X              X           X   |             
      Mixed Tumor Benign                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
      Polyp Stromal                        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   M                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X           X        X           X              X           X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                      X   |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |    X                                                                     |             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |          X           X        X           X              X  X        X   |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  M  +  M  +  M  +  +  +  +  M  M  +  +  M  +  A  +  M|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X           X              X           X   |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|             
                             DAY ON TEST   | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|             
                                           | 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |    X                                                                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X           X                    X              X  X        X   |             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  A  +  +|             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |          X                    X           X                          X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                               X           X              X           X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |    X                                                                     |             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |          X           X                    X              X  X        X   |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |       X     X                       X                                    |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X                          X   |             
      Mixed Tumor Malignant                |                                                             X            |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                       X                  |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Metastatic, Heart               |                                                                         X|             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
      Subcutaneous Tissue, Sarcoma         | X                                                                        |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Squamous Cell   |                                                                          |             
          Carcinoma, Metastatic, Stomach   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|             
                             DAY ON TEST   | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|             
                                           | 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |          X                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |             
          Stomach                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X              X               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                +                          +   |             
      Lymphoma Malignant Lymphocytic       |                                           X                          X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |             X                                                            |             
      Alveolar/Bronchiolar Adenoma         |                X                    X                                    |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                X         |             
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                             X            |             
      Hemangiosarcoma, Metastatic, Heart   |             X                    X                 X                    X|             
      Hemangiosarcoma, Metastatic, Skin    |                                                       X                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                X         |             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |          X           X                    X              X  X            |             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Mammary Gland                   |                                                             X            |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |    X                                                        X            |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Heart                |                                                    X                     |             
      Mediastinum, Mixed Tumor Malignant,  |                                                                          |             
           Metastatic, Mammary Gland       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 3| 3| 4| 2| 2| 2| 0| 2| 2| 3| 2| 3| 2| 2| 2| 4| 3| 2| 4| 4| 2| 3| 3|             
                             DAY ON TEST   | 0| 8| 4| 3| 5| 8| 7| 2| 1| 8| 8| 9| 8| 0| 4| 8| 8| 2| 5| 5| 2| 1| 9| 2| 7|             
                                           | 1| 7| 1| 0| 7| 5| 2| 1| 1| 2| 2| 2| 0| 0| 6| 2| 2| 5| 6| 3| 5| 8| 6| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Mediastinum, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Stomach             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                           X              X               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X     X                 X                          X                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |    X                                                                     |             
      Hemangiosarcoma, Metastatic, Heart   |                                                                          |             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                           X              X  X            |             
      Lymphoma Malignant                   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Lymphocytic       |                                           X                          X   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                        X                                 |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X           X        X           X              X  X        X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3|                             |            |
                             DAY ON TEST   | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6|                             |            |
                                           | 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                              |  89        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  64        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  87        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  78        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  83        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  83        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  80        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  72        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  75        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  70        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Heart   | X     X        X     X        X                                          |         20 |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                               X                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          4 |
      Lymphoma Malignant Lymphocytic       |          X  X           X           X                                    |         23 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                      X           X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   6        |
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |          1 |
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |            |
           Heart                           |                                                                          |          1 |
      Fat, Hemangiosarcoma, Metastatic,    |                                                                          |            |
           Spleen                          |                                                                          |          1 |
      Fat, Sarcoma, Metastatic, Stomach    |                                                                          |          1 |
      Fat, Squamous Cell Carcinoma,        |                                                                          |            |
          Metastatic, Stomach              |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  88        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  96                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3|                             |            |
                             DAY ON TEST   | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6|                             |            |
                                           | 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |          1 |
      Acinus, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |             X           X                                                |          7 |
      Acinus, Squamous Cell Carcinoma,     |                                                                          |            |
           Metastatic, Stomach             |                      X           X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  89        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          5 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  89        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  89        |
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |          7 |
      Sarcoma                              |                                                                          |          1 |
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |          1 |
      Squamous Cell Carcinoma              |                      X        X  X                                       |          7 |
      Squamous Cell Papilloma              | X              X                          X                              |         15 |
      Squamous Cell Papilloma, Multiple    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  86        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |          7 |
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                      X           X                                       |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
      Hemangiosarcoma                      | X     X        X     X        X                                          |         25 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |             X              X           X                                 |         19 |
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  88        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  88        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          9 |
      Sarcoma, Metastatic, Stomach         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  86        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  97                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3|                             |            |
                             DAY ON TEST   | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6|                             |            |
                                           | 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  88        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +                              |  77        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +                              |  80        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          8 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  88        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          2 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  89        |
      Adenoma                              |                                                                          |          1 |
      Granulosa Cell Tumor Benign          |                         X     X                                          |          7 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |          X  X                          X                                 |         19 |
      Mixed Tumor Benign                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  88        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          9 |
      Polyp Stromal                        |                X              X                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  89        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |          X  X           X  X        X  X  X                              |         31 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  89        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                         X                                                |          6 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  98                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3|                             |            |
                             DAY ON TEST   | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6|                             |            |
                                           | 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Lymphocytic                      |                                                                          |          4 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  M  +  M  M  M  +  +  +  M  +  +  +                              |  62        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |             X           X  X        X  X                                 |         29 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  I  +  +  +  +  I  +  M  M  +  +  +  +                              |  64        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |          X  X           X              X  X                              |         23 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  M  +  +  +  +  +  +  +  +                              |  74        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |          X  X           X  X        X  X  X                              |         29 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Sarcoma, Metastatic, Mammary Gland   |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                      X           X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +                              |  81        |
      Histiocytic Sarcoma                  |                                                                          |          4 |
      Lymphoma Malignant Lymphocytic       |          X  X           X           X  X  X                              |         24 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  88        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          4 |
      Lymphoma Malignant Lymphocytic       |          X  X           X  X        X  X  X                              |         27 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +                              |  81        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       |          X  X           X  X        X  X  X                              |         31 |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  99                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3|                             |            |
                             DAY ON TEST   | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6|                             |            |
                                           | 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                              |  87        |
      Adenocarcinoma                       |                X           X              X                              |         13 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          5 |
      Mixed Tumor Malignant                |       X                                                                  |          4 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  89        |
      Keratoacanthoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          2 |
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |            |
           Metastatic, Heart               |                                                                          |          2 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                               X                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          2 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Multiple                         |    X                                                                     |          1 |
      Subcutaneous Tissue, Squamous Cell   |                                                                          |            |
          Carcinoma, Metastatic, Stomach   |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
      Vertebra, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |            |
          Stomach                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
      Hemangiosarcoma, Metastatic, Heart   | X                                                                        |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |         10 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   9        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          8 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  82        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  88        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 100                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3|                             |            |
                             DAY ON TEST   | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6|                             |            |
                                           | 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                X                                                         |          5 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |         15 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                               X                                          |          4 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          5 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                            X                                             |          3 |
      Hemangiosarcoma, Metastatic, Heart   | X                                                                        |         15 |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          4 |
      Lymphoma Malignant Lymphocytic       |             X           X  X        X  X                                 |         22 |
      Mixed Tumor Malignant, Metastatic,   |                                                                          |            |
           Mammary Gland                   |                                                                          |          3 |
      Sarcoma, Metastatic, Skin            |    X                                                                     |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                      X                                                   |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          3 |
      Mediastinum, Hemangiosarcoma,        |                                                                          |            |
          Metastatic, Heart                |                                                                          |          1 |
      Mediastinum, Mixed Tumor Malignant,  |                                                                          |            |
           Metastatic, Mammary Gland       |                                                                          |          1 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Skin                            |    X                                                                     |          1 |
      Mediastinum, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Stomach             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  89        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          5 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  83        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  M  +  +  M  +  +  +  +  +  M  +  +                              |  73        |
      Adenoma                              |             X  X                 X                                       |         10 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 101                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 2| 3| 4| 2| 3| 3| 3| 4| 4| 2| 2| 3|                             |            |
                             DAY ON TEST   | 6| 1| 5| 5| 1| 1| 3| 7| 1| 8| 5| 1| 3| 8| 6|                             |            |
                                           | 7| 6| 7| 7| 6| 8| 0| 6| 5| 5| 7| 8| 2| 0| 4|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |     A      |
    625 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                             |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                             |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Heart   |                               X                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          4 |
      Lymphoma Malignant Lymphocytic       |          X  X           X  X           X                                 |         21 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +                              |  85        |
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |          9 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  90        |
      Histiocytic Sarcoma                  |                                                                          |          4 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |          X  X           X  X        X  X  X                              |         32 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 102                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 4| 7| 2| 7| 7| 7| 6| 2| 6| 5| 6| 7| 7| 7| 2| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 5| 3| 8| 3| 3| 3| 2| 8| 6| 1| 5| 3| 3| 3| 8| 3| 3| 5| 3| 7| 3| 3| 3|             
                                           | 6| 1| 6| 6| 1| 6| 6| 6| 7| 1| 6| 1| 2| 6| 6| 6| 1| 6| 6| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                         X                             X        X         |             
      Hepatocellular Carcinoma, Multiple   |                X                    X                                    |             
      Hepatocellular Adenoma               |    X                 X     X        X              X                     |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X                             X         |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +     +                              |             
      Fat, Sarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                  X                                       |             
      Acinus, Lymphoma Malignant Mixed     |                               X                                          |             
      Acinus, Sarcoma, Metastatic, Skin    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor NOS, Metastatic,     |                                                                          |             
           Bone Marrow                     |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +  +        +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 4| 7| 2| 7| 7| 7| 6| 2| 6| 5| 6| 7| 7| 7| 2| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 5| 3| 8| 3| 3| 3| 2| 8| 6| 1| 5| 3| 3| 3| 8| 3| 3| 5| 3| 7| 3| 3| 3|             
                                           | 6| 1| 6| 6| 1| 6| 6| 6| 7| 1| 6| 1| 2| 6| 6| 6| 1| 6| 6| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  M  M  +  +  I  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                 +                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor NOS                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Mast Cell Tumor NOS, Metastatic,     |                                                                          |             
           Bone Marrow                     |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                               X                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                X         |             
      Renal, Lymphoma Malignant Mixed      |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  M  +  +  +  M  M  M  M  +  +  +  +  M  +  +  +|             
      Mast Cell Tumor NOS, Metastatic,     |                                                                          |             
           Bone Marrow                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  M  M  +  +  +  +  +  +  M  M  +  M  +  M  M  +  M  M  +  M  M  M|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 4| 7| 2| 7| 7| 7| 6| 2| 6| 5| 6| 7| 7| 7| 2| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 5| 3| 8| 3| 3| 3| 2| 8| 6| 1| 5| 3| 3| 3| 8| 3| 3| 5| 3| 7| 3| 3| 3|             
                                           | 6| 1| 6| 6| 1| 6| 6| 6| 7| 1| 6| 1| 2| 6| 6| 6| 1| 6| 6| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                             X         |             
      Lymphoma Malignant Mixed             |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  +  M  M  M  M  +  M  M  M  M  M  M  M  M  M  +  M  M  I  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X        X                                                  X     X  X   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                   X                                   X                  |             
      Alveolar/Bronchiolar Carcinoma       |                                        X                                X|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                       X                  |             
      Carcinoma, Metastatic, Liver         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                X                                                         |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X                             X         |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Mediastinum,                         |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 4| 7| 2| 7| 7| 7| 6| 2| 6| 5| 6| 7| 7| 7| 2| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 5| 3| 8| 3| 3| 3| 2| 8| 6| 1| 5| 3| 3| 3| 8| 3| 3| 5| 3| 7| 3| 3| 3|             
                                           | 6| 1| 6| 6| 1| 6| 6| 6| 7| 1| 6| 1| 2| 6| 6| 6| 1| 6| 6| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                       X        X         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +                                +                                       |             
      Adenoma                              | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                  X                             X         |             
      Lymphoma Malignant Mixed             |          X                    X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 4| 7| 2| 7| 2| 7| 6| 7| 4| 7| 6| 2| 7| 4| 4| 2| 7| 5| 4| 4| 5| 3|             
                             DAY ON TEST   | 8| 5| 3| 5| 3| 8| 3| 8| 3| 9| 3| 5| 1| 0| 8| 3| 9| 5| 8| 3| 7| 5| 5| 4| 7|             
                                           | 1| 6| 6| 6| 6| 1| 6| 1| 6| 3| 6| 6| 4| 9| 1| 6| 5| 6| 1| 6| 2| 6| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                        X                                 |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |       X        X                                                        X|             
      Hepatocellular Adenoma, Multiple     |                               X                                          |             
      Hepatocholangiocarcinoma             |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                         +            |             
      Fat, Sarcoma, Metastatic, Skin       |                                                             X            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Acinus, Lymphoma Malignant Mixed     |                                                                          |             
      Acinus, Sarcoma, Metastatic, Skin    |                                                             X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor NOS, Metastatic,     |                                                                          |             
           Bone Marrow                     |                                        X                                 |             
      Sarcoma, Metastatic, Skin            |                                                             X            |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                          +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 4| 7| 2| 7| 2| 7| 6| 7| 4| 7| 6| 2| 7| 4| 4| 2| 7| 5| 4| 4| 5| 3|             
                             DAY ON TEST   | 8| 5| 3| 5| 3| 8| 3| 8| 3| 9| 3| 5| 1| 0| 8| 3| 9| 5| 8| 3| 7| 5| 5| 4| 7|             
                                           | 1| 6| 6| 6| 6| 1| 6| 1| 6| 3| 6| 6| 4| 9| 1| 6| 5| 6| 1| 6| 2| 6| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                 +                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +              +  +              +  M                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor NOS                  |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Mast Cell Tumor NOS, Metastatic,     |                                                                          |             
           Bone Marrow                     |                                        X                                 |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +|             
      Mast Cell Tumor NOS, Metastatic,     |                                                                          |             
           Bone Marrow                     |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | I  +  +  +  +  M  +  +  +  M  M  +  M  +  +  +  M  +  M  +  +  M  M  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05134-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 04/02/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:02:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 4| 7| 2| 7| 2| 7| 6| 7| 4| 7| 6| 2| 7| 4| 4| 2| 7| 5| 4| 4| 5| 3|             
                             DAY ON TEST   | 8| 5| 3| 5| 3| 8| 3| 8| 3| 9| 3| 5| 1| 0| 8| 3| 9| 5| 8| 3| 7| 5| 5| 4| 7|             
                                           | 1| 6| 6| 6| 6| 1| 6| 1| 6| 3| 6| 6| 4| 9| 1| 6| 5| 6| 1| 6| 2| 6| 6| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +                                 |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X  X                 X              X            |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Carcinoma, Metastatic, Liver         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                             X            |             
      Mediastinum,                         |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _________________________________________________________________________________________