https://ntp.niehs.nih.gov/go/2944

TDMS Study 05134-02 Pathology Tables

NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13
                                                          CORE ANIMALS
       Facility:  Battelle Northwest
       Chemical CAS #:  106-99-0
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    25008 Accident                          25004 Dead
                               25009 Missing                           25003 Moribund
                               25006 Terminal Sacrifice
       Removal Date Range:     01/01/40 - 12/30/99
       Treatment Groups:       Include 001    CONTROL
                               Include 002    CONTROL
                               Include 003    6.25 PPM
                               Include 004    6.25 PPM
                               Include 005    20 PPM
                               Include 006    20 PPM
                               Include 007    62.5 PPM
                               Include 008    62.5 PPM
                               Include 009    200 PPM
                               Include 010    200 PPM
                               Include 011    625 PPM
                               Include 012    625 PPM
                                                              Page   1
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 1| 5| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1|             
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 1| 4| 1| 2| 3| 4| 5| 2| 3| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M|             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia                          |                                                       1                  |             
      Inflammation                         |                                     1                                    |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                 X                        |             
      Clear Cell Focus                     |                                                                      X   |             
      Eosinophilic Focus                   |          X                 X                          X                  |             
      Hematopoietic Cell Proliferation     |                   1     2                                         3      |             
      Inflammation, Chronic                |                                                       1                  |             
      Inflammation, Focal, Granulomatous   |                               2                                          |             
      Necrosis                             |                                                       1        2         |             
      Biliary Tract, Cyst                  | X                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +                    +        +     +           +      |             
      Fat, Angiectasis                     |    2              1                                                      |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Inflammation, Chronic           |    2              2                                               2      |             
      Fat, Necrosis                        |                                        2        2                 4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                            4                 1                           |             
      Acinus, Focal Cellular Change        |                                           2                       1      |             
      Acinus, Hyperplasia                  |                                                    2                     |             
      Acinus, Inflammation, Chronic        |                                                                          |             
      Duct, Cyst                           |                            3                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1        1                                1                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                         1     1                                          |             
      Epithelium, Hyperplasia              |                         1     2                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                2         |             
      Ulcer                                |                                                                2         |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 1| 5| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1|             
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 1| 4| 1| 2| 3| 4| 5| 2| 3| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2                                            1  1               |             
      Perivascular, Inflammation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hyperplasia                          |                         1                    1                           |             
      Hypertrophy                          |                                                    1                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1           2                                      1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         4|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  M  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                      1   |             
      Pars Distalis, Hyperplasia           | 3           3           2        1     1                    2  2     1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          4               |             
      Inflammation                         |                                                                          |             
      Follicular Cell, Hyperplasia         |                                  1           1  1     4  1  1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                           M                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2     2                                               2         |             
      Atrophy                              |                      2                             3        2            |             
      Cyst                                 |                   X        1                          X              X   |             
      Germinal Epithelium, Hyperplasia     |                                  2                                       |             
      Granulosa Cell, Hyperplasia          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                   1                                    |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                     X                                    |             
      Dilatation                           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 1| 5| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1|             
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 1| 4| 1| 2| 3| 4| 5| 2| 3| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Cystic                  | 3  3  3  1  3  2  3  2  2  2  2  3  3  2  2  2  3  3  2  4  2        2  3|             
      Inflammation                         |                                              2                           |             
      Arteriole, Hypertrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2  2  2                                         3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                   3      |             
      Hyperplasia                          |       3                       2  2                                   2  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  M  +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +  +  M|             
      Congestion                           |                                                                2         |             
      Hematopoietic Cell Proliferation     |                         2                                         2      |             
      Hyperplasia                          |                   3           1                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  M  I  +  M  M  +  M  +  +  +  +  M  +  +  +  +  M  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                   1      |             
      Hyperplasia                          |       3           4                                   2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2        2|             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia                          |       3                       1           4  2              1        2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    1  2  2  1  2  3  2  3        2  1  2     1  1  1  2  2  2  2  3  1   |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                               2                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          2     2  4     1     2                                      2   |             
      Necrosis                             |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                           1                              |             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrous Osteodystrophy               | 2  2  2  2  2        2  2  2  1  1  1  1     2  1  2     1  1        2  1|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 1| 5| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 1| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1|             
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 1| 4| 1| 2| 3| 4| 5| 2| 3| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                           3                              |             
      Mineralization                       |          1     1              1  1  1  1     1     1     1     1     1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    1                     |             
      Hyperplasia, Lymphoid                |                   4                                                      |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2           3                 2                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                    2                     |             
      Alveolus, Pigmentation, Hemosiderin  |                                                    2                     |             
      Fat, Mediastinum, Inflammation,      |                                                                          |             
          Chronic                          |                                                                   2      |             
      Fat, Mediastinum, Necrosis           |                                                                   4      |             
      Mediastinum, Hyperplasia, Lymphoid   |       2                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            1  1                 1  1        1  1     1  1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                    2                     |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   1           1           1        1                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Degeneration                         |                   4                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                       2              2   |             
      Infiltration Cellular, Lymphocyte    |                   3                                                      |             
      Inflammation, Suppurative            |                   1                                                      |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1        1     1                 1     1  1              1        1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Inflammation                         |                   2                                                  3   |             
      Transitional Epithelium, Hyperplasia |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5|            |
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8|      L     |
                                           | 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|  41        |
      Acanthosis                           |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  I  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                 X                        |      2     |
      Eosinophilic Focus                   |                X        X                                                |      5     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  1.5|
      Biliary Tract, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        +  +  +           +                             +      |  12        |
      Fat, Angiectasis                     |                         2                                                |      3  1.7|
      Fat, Hemorrhage                      |          2                                                               |      1  2.0|
      Fat, Inflammation, Chronic           |                   2                                                      |      4  2.0|
      Fat, Necrosis                        |          2           3  1           2                             2      |      8  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                                                                         4|      3  3.0|
      Acinus, Focal Cellular Change        |                               1                                          |      3  1.3|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Acinus, Inflammation, Chronic        |                                                             2           4|      2  3.0|
      Duct, Cyst                           |                                                                         4|      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      2  1.0|
      Epithelium, Hyperplasia              |          2                                                               |      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5|            |
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8|      L     |
                                           | 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pigmentation, Hemosiderin            |                                     2                                    |      2  2.0|
      Ulcer                                |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                +  +            |   4        |
      Developmental Malformation           |                                                             X            |      1     |
      Inflammation                         |                         1                                1               |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                         +|   1        |
      Inflammation                         |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                    1                     |      4  1.3|
      Perivascular, Inflammation           |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                1                                                         |      3  1.0|
      Hypertrophy                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             2                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |       1                    1                       1  1        1         |     13  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation                         |                         1                                         1      |      2  1.0|
      Follicular Cell, Hyperplasia         |    1           3                       1     3                 2         |     11  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5|            |
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8|      L     |
                                           | 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                      1                                                   |      4  1.8|
      Atrophy                              |                            1                                             |      4  2.0|
      Cyst                                 |       X  X  X        X  X  X           X        X  X              X      |     14  1.0|
      Germinal Epithelium, Hyperplasia     |                                        1                                 |      2  1.5|
      Granulosa Cell, Hyperplasia          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2                                                                     |      3  1.7|
      Atrophy                              |                                     1                                    |      1  1.0|
      Cyst                                 |                                                                          |      1     |
      Dilatation                           |    2                                                                     |      2  2.5|
      Hyperplasia, Cystic                  | 1  1  1  4  3  2  2  3  3  2  1  3     3  2  3  1  2  2  3  2  3  3     2|     46  2.4|
      Inflammation                         |                                                                          |      1  2.0|
      Arteriole, Hypertrophy               |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|  43        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia                          |                   2  2                       2  2                        |      9  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  M  +  M  +  +  +  +|  39        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia                          |    2     2        2                                                     2|      7  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  M  +  +  +  M  M  +  +  M  +  M  M  M  +  M  +  +  +  M  +  +  +|  30        |
      Hematopoietic Cell Proliferation     |       1                                                                  |      2  1.0|
      Hyperplasia                          |       1           2                             2                        |      6  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |    1                                                                     |      3  1.7|
      Hematopoietic Cell Proliferation     |             1                                                            |      2  1.5|
      Hyperplasia, Histiocytic             |                                        4                                 |      1  4.0|
      Hyperplasia                          |          2                       1           1                           |      9  1.9|
                                            __________________________________________________________________________|____________|
   Spleen                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |       2        1  1  1  1                                      2        1|     27  1.7|
      Hyperplasia, Histiocytic             |                                              4                           |      1  4.0|
      Hyperplasia, Lymphoid                |          4                                                               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Hyperplasia, Lymphoid                |          1              1                                                |      8  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5|            |
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8|      L     |
                                           | 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Galactocele                          |                                                                          |      1  1.0|
      Hyperplasia                          |    1                                                                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                                 X                        |      1     |
      Fibrous Osteodystrophy               |    2  2  2  2  1  2  2  2  2     1     2  2  2  1  2  2  2     1  1      |     38  1.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  3.0|
      Mineralization                       |       1     1  1  1     1  1     1     1           1           1        1|     23  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              2           1               |      3  1.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Inflammation, Chronic, Focal         |                                  1                       1              2|      3  1.3|
      Alveolar Epithelium, Hyperplasia     |                1                             2                           |      5  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Alveolus, Pigmentation, Hemosiderin  |                                                                          |      1  2.0|
      Fat, Mediastinum, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
      Fat, Mediastinum, Necrosis           |                                                                          |      1  4.0|
      Mediastinum, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                2  1  1  1           1  1        1           4     1      |     17  1.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                         2|      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 3| 0| 8| 5|            |
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 7| 4| 7| 1| 7| 8| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    CONTROL                                | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8|      L     |
                                           | 3| 4| 1| 2| 4| 5| 3| 4| 2| 3| 5| 1| 2| 3| 4| 1| 2| 5| 2| 3| 4| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Atrophy        |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          1     1  1              1        1  1                 1  1      |     12  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                         +|   2        |
      Degeneration                         |                                                                         4|      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1                                                                        |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                                                                          |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                         1                                                |      1  1.0|
      Nephropathy                          |                1                       1                          1      |     11  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation                         |                                                                          |      2  2.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 5| 7| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 1| 3| 3| 3| 6| 5| 3|             
                                           | 5| 5| 2| 5| 2| 5| 5| 5| 5| 2| 5| 5| 5| 5| 4| 5| 7| 2| 9| 5| 5| 5| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6.25 PPM                               | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                 1                       2               |             
      Basophilic Focus                     |                                                          X               |             
      Clear Cell Focus                     |                   X                                                      |             
      Degeneration, Fatty                  |                   4                                            1         |             
      Eosinophilic Focus                   |          X     X                             X     X                     |             
      Hematopoietic Cell Proliferation     |                            4                 2        1  2               |             
      Inflammation, Chronic                |                                  4                                       |             
      Inflammation, Focal, Granulomatous   |                      2                                                   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |          1                                                        4      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +     +           +                             +         |             
      Fat, Angiectasis                     |                      2                                                   |             
      Fat, Ectopic Tissue                  |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                3         |             
      Fat, Necrosis                        |                2     2           2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          1                                                               |             
      Acinus, Focal Cellular Change        |                         2                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                      1   |             
      Epithelium, Hyperplasia              |                   2                                                  3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                +              +                  |             
      Inflammation                         |       1                                2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 5| 7| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 1| 3| 3| 3| 6| 5| 3|             
                                           | 5| 5| 2| 5| 2| 5| 5| 5| 5| 2| 5| 5| 5| 5| 4| 5| 7| 2| 9| 5| 5| 5| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6.25 PPM                               | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
      Inflammation                         |                                                                      3   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Mineralization                       |                                                                          |             
      Endothelium, Hyperplasia             |                            1                                             |             
      Perivascular, Inflammation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                        1                                 |             
      Hypertrophy                          |                   1                                                      |             
      Capsule, Hyperplasia                 |             2                 2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  I  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  +  +  +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                         X                                                |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |          1  1  1  1     1        1     1                 4     4        1|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 | X              X                                                         |             
      Follicular Cell, Hyperplasia         |                                  1     1  3  2           2  2  1     3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                        1   |             
      Atrophy                              |             2           3  3  2  2     2           2        3  2        2|             
      Cyst                                 |    X  X     X     X     X  X     X        X  X     X  X  X     X  X      |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                     1                                    |             
      Corpus Luteum, Hyperplasia           |                                                                         2|             
      Germinal Epithelium, Hyperplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 5| 7| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 1| 3| 3| 3| 6| 5| 3|             
                                           | 5| 5| 2| 5| 2| 5| 5| 5| 5| 2| 5| 5| 5| 5| 4| 5| 7| 2| 9| 5| 5| 5| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6.25 PPM                               | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2  2                    2               |             
      Dilatation                           |                                                          3               |             
      Hemorrhage                           |                      3                                                   |             
      Hyperplasia, Cystic                  | 2  4  2  2  2  2  2  3  3  4  1  4  2  2  1  3     3  2     1  3     2  3|             
      Inflammation                         |                                                                          |             
      Arteriole, Hypertrophy               |                                                                          |             
      Cervix, Cyst                         |                         X                                                |             
      Muscularis, Hyperplasia              |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                 2                 2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Hyperplasia              |                                                                          |             
      Renal, Hyperplasia                   |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Congestion                           |                                           2                              |             
      Hyperplasia                          |          1        2        3  1        3              2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2        2  1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  M  M  +  +  M  +  +  M  +  M  +  +  +  M  +  +  +  M  M  +  +  M|             
      Angiectasis                          |                            3                                             |             
      Congestion                           |                                           2                              |             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    1     2        2        3           2                    2  1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  2  1     1     2  1  2        1  1  2  3     2     2  1            |             
      Hyperplasia, Lymphoid                |                   4                                                     1|             
      Inflammation, Focal, Granulomatous   |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |          1     1  2                 1  3                    1  1         |             
      Necrosis                             |       2                    2                          2              1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 5| 7| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 1| 3| 3| 3| 6| 5| 3|             
                                           | 5| 5| 2| 5| 2| 5| 5| 5| 5| 2| 5| 5| 5| 5| 4| 5| 7| 2| 9| 5| 5| 5| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    6.25 PPM                               | 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 1| 2| 3| 5| 1| 3| 4| 5| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 1     1  2  2  1  2  1  1  1  1        1           2        3  1     1  2|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    1     1  1  1        1           1  1     1              1     1     1|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        1                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         |                                                             2            |             
      Inflammation, Suppurative            |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                            2                          4                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1        1           1     1        1                 1  1        1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1     1  1        1  1     1     1  1              1  1               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                1                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                              1                           |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |    1                                   1                    1            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  M  +  M  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    6.25 PPM                               | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M|  41        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
      Hemorrhage                           |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|  46        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 2                                                                 1      |      5  1.6|
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Fatty                  |                                                                          |      2  2.5|
      Eosinophilic Focus                   | X        X  X     X  X  X              X                                 |     11     |
      Hematopoietic Cell Proliferation     |                                           1                    3         |      6  2.2|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                     X                                    |      1     |
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +  +        +  +  +  +              +                 +|  13        |
      Fat, Angiectasis                     |                      2              4                                    |      3  2.7|
      Fat, Ectopic Tissue                  |                                     X                                    |      1     |
      Fat, Inflammation, Chronic           |                               2  2                                       |      3  2.3|
      Fat, Necrosis                        |                                  3     3                                2|      6  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |          2                                                     1         |      3  1.3|
      Acinus, Focal Cellular Change        | 1        1                    2                 1                        |      5  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst Epithelial Inclusion            | 3                                                                        |      1  3.0|
      Ulcer                                |                            1                                             |      2  1.0|
      Epithelium, Hyperplasia              | 2           2              2                                             |      5  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hemorrhage                           |                                           2                              |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    6.25 PPM                               | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |             1                                                            |      1  1.0|
      Pigmentation, Hemosiderin            |                                           2        2                     |      2  2.0|
      Ulcer                                |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +     +                                                               |   5        |
      Inflammation                         |    1     2                                                               |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                  1                             1         |      2  1.0|
      Mineralization                       |                                           1        2                     |      2  1.5|
      Endothelium, Hyperplasia             |                1                                                         |      2  1.0|
      Perivascular, Inflammation           |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Focal Cellular Change                |                                  2                                   4   |      3  2.3|
      Hypertrophy                          |          1                                   2                           |      3  1.3|
      Capsule, Hyperplasia                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  M|  40        |
      Cyst                                 |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                       1              1   |      2  1.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hemorrhage            |                                                                   1      |      1  1.0|
      Pars Distalis, Hyperplasia           |    4  2     2     4  3  3                    2        2              1   |     19  2.1|
      Pars Intermedia, Hyperplasia         |    2                                1                                    |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |    X                             X                    X                 X|      6     |
      Follicular Cell, Hyperplasia         |             2                                                     1      |     10  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    6.25 PPM                               | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       M                                                                  |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                         2                       2     2     3            |      6  2.0|
      Atrophy                              |    2     2  2        2        2           2        3  2           2      |     19  2.2|
      Cyst                                 |          X  X  X     X     X  X  X           X  X     X  X  X           X|     27     |
      Metaplasia, Osseous                  |                                                          1               |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Corpus Luteum, Hyperplasia           |                                                                          |      1  2.0|
      Germinal Epithelium, Hyperplasia     |    1     1                                                           1   |      3  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |    1                                            3  4                 2  3|      8  2.4|
      Dilatation                           | 3                                                                        |      2  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Cystic                  | 1  4  2  4  3  4  3  3  2  2  1  3  3  2  1  3  3  2  2  1  2  2  3  2  3|     47  2.4|
      Inflammation                         | 3                                                                        |      1  3.0|
      Arteriole, Hypertrophy               |                               2                                          |      1  2.0|
      Cervix, Cyst                         |                                                                          |      1     |
      Muscularis, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                   2                                            2         |      5  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pancreatic, Hyperplasia              |             2                                                            |      1  2.0|
      Renal, Hyperplasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  I  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +|  42        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                            1                 1        1           2      |     10  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +|  42        |
      Hyperplasia                          |          2                                                              2|      5  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  +  M  +  +  M  M  +  +  +  M  +  +  +  M  +  +  M  M  +  M  +  +  M|  29        |
      Angiectasis                          |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Angiectasis                          |             1        1                                                   |      2  1.0|
      Congestion                           |             3                                                            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    6.25 PPM                               | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                2         |      1  2.0|
      Hemorrhage                           |                                           4                              |      1  4.0|
      Hyperplasia                          | 1  1        2        4  1  1                 1        1           1  1   |     17  1.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |    1  2  1  1           2     2     2     2     2              3         |     25  1.6|
      Hyperplasia, Lymphoid                |                                                                         2|      3  2.3|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Angiectasis                          |                      1              1                                    |      2  1.0|
      Hyperplasia, Lymphoid                |    2     2           2  1                    2                    1     1|     14  1.5|
      Necrosis                             |       2                                   2                              |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                          1               |      1  1.0|
      Inflammation, Chronic                |                                                          1               |      1  1.0|
      Subcutaneous Tissue, Edema           |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 2  2  1  1  2  1  2  1  1  2     2  2  1  1  1  1     2           1  2  3|     36  1.5|
      Osteopetrosis                        | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       | 1        1  1     1  1  1  1  1  1  1  1           1                 1   |     24  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                            1     1                                       |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                   1                       1                    2         |      4  1.3|
      Hyperplasia, Lymphoid                |                                                                      3   |      1  3.0|
      Inflammation, Chronic, Focal         |                                  2                                       |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                   1     3        1  1                          3         |      5  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 7| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3|            |
                                           | 5| 5| 2| 6| 6| 8| 6| 6| 6| 6| 4| 6| 6| 5| 3| 6| 6| 0| 6| 4| 1| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    6.25 PPM                               | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| 2| 3| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                      3   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |             1                       1                 1        1         |     12  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1        1  1                 1           1        1              1   |     17  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 1                                         1     1                        |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                         3|      1  3.0|
      Metaplasia, Osseous                  | 1                                                                        |      1  1.0|
      Nephropathy                          |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation                         |                                                          1               |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 6| 7| 6| 7| 6| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 6| 5| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 3| 4| 9| 7| 3| 8| 3| 9| 0| 3| 3| 5| 3| 3| 9| 3| 5| 3| 5| 6| 3| 3| 3| 4| 7|             
                                           | 4| 5| 4| 7| 4| 1| 4| 7| 7| 4| 4| 0| 3| 4| 1| 4| 3| 4| 7| 9| 4| 4| 4| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    20 PPM                                 | 1| 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8|             
                                           | 1| 2| 3| 1| 2| 4| 5| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endothelium, Hyperplasia             |                            4                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Degeneration, Fatty                  | 1                                                                        |             
      Eosinophilic Focus                   | X                       X  X  X        X        X           X  X  X      |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Infarct                              |                                              4                           |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Necrosis                             |                2     1                                         1        2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +           +                                +  +     +|             
      Fat, Angiectasis                     | 2                             3                                   3      |             
      Fat, Hemorrhage                      |                                                                         2|             
      Fat, Inflammation, Chronic           |                   2                                            3  3      |             
      Fat, Necrosis                        |                   2                                               3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                2         |             
      Acinus, Focal Cellular Change        |                                  1                 1                     |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Inflammation, Chronic        |                                                                2         |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1                                                                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                1                                                         |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                1                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                         2|             
      Ulcer                                |                                                                         2|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 6| 7| 6| 7| 6| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 6| 5| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 3| 4| 9| 7| 3| 8| 3| 9| 0| 3| 3| 5| 3| 3| 9| 3| 5| 3| 5| 6| 3| 3| 3| 4| 7|             
                                           | 4| 5| 4| 7| 4| 1| 4| 7| 7| 4| 4| 0| 3| 4| 1| 4| 3| 4| 7| 9| 4| 4| 4| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    20 PPM                                 | 1| 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8|             
                                           | 1| 2| 3| 1| 2| 4| 5| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Endothelium, Hyperplasia             |                                                       1                  |             
      Perivascular, Inflammation           |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                X         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  M  +  M  M  +  +  +  +  +  M  M  M  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2                                      2                                 |             
      Pars Distalis, Cyst                  |                                                                      X   |             
      Pars Distalis, Hyperplasia           | 2        1                             1        2        1        2      |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation                         |                                           2           2                  |             
      Follicular Cell, Hyperplasia         | 1              2           1           3     1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |    2        2  2  2  3        2  2     2     2     2  2     2  2  2     3|             
      Cyst                                 |             X  X           X     X           X     X           X     X   |             
      Germinal Epithelium, Hyperplasia     |             1                          2                 1               |             
      Granulosa Cell, Hyperplasia          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2     4  4        2  4     2  4                              |             
      Atrophy                              |       1                                                                  |             
      Hemorrhage                           |                                        4                                 |             
      Hyperplasia, Cystic                  |    1        2  2  2  1  1  2  1  2     4  1  2  3  2     1  2  1  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 6| 7| 6| 7| 6| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 6| 5| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 3| 4| 9| 7| 3| 8| 3| 9| 0| 3| 3| 5| 3| 3| 9| 3| 5| 3| 5| 6| 3| 3| 3| 4| 7|             
                                           | 4| 5| 4| 7| 4| 1| 4| 7| 7| 4| 4| 0| 3| 4| 1| 4| 3| 4| 7| 9| 4| 4| 4| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    20 PPM                                 | 1| 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8|             
                                           | 1| 2| 3| 1| 2| 4| 5| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              1                           |             
      Hyperplasia                          |    2                             2                 2     3           2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   4                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2           3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  A  +  +  +  M  +  M  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Congestion                           |                                                 2                        |             
      Hematopoietic Cell Proliferation     |                                              2                          4|             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Hematopoietic Cell Proliferation     |             2     4              2     1     3  2  2     2     2     2  4|             
      Hemorrhage                           |                                                                         4|             
      Hyperplasia, Lymphoid                |                                                             2            |             
      Capsule, Inflammation, Chronic       |                                                                3        2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                      2           2                                      2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |    2                                                                     |             
      Hyperplasia                          |    1                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Necrosis                             |                                     3                                    |             
      Hair Follicle, Atrophy               |          2              3                                                |             
      Subcutaneous Tissue, Hemorrhage      |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |             2  2  1        1  2  2     1           2  1     2  2  1  2   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 6| 7| 6| 7| 6| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 6| 5| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 3| 4| 9| 7| 3| 8| 3| 9| 0| 3| 3| 5| 3| 3| 9| 3| 5| 3| 5| 6| 3| 3| 3| 4| 7|             
                                           | 4| 5| 4| 7| 4| 1| 4| 7| 7| 4| 4| 0| 3| 4| 1| 4| 3| 4| 7| 9| 4| 4| 4| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    20 PPM                                 | 1| 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8|             
                                           | 1| 2| 3| 1| 2| 4| 5| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    2                                                                     |             
      Hemorrhage                           |       1        2                                                        2|             
      Mineralization                       |    1        1     1                    1  1  1              1     1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     3                                    |             
      Infiltration Cellular, Mixed Cell    |                                                          2               |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                   3     4                                                |             
      Alveolus, Pigmentation, Hemosiderin  |                                                                          |             
      Fat, Mediastinum, Necrosis           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   1                 1              1                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                1                    1                    1           1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1              1                    1           1        1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          A                                                               |             
                                            __________________________________________________________________________|             
   Eye                                     |                M                                                     +   |             
      Degeneration                         |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                      2   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                       1                       1           2           1|             
      Inflammation, Chronic                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                      1                                            1      |             
      Nephropathy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7|            |
                             DAY ON TEST   | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    20 PPM                                 | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|      L     |
                                           | 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  41        |
      Inflammation                         |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  47        |
      Endothelium, Hyperplasia             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                               4                                          |      1  4.0|
      Basophilic Focus                     |                                           X                              |      1     |
      Degeneration, Fatty                  |                                                                          |      1  1.0|
      Eosinophilic Focus                   |             X           X        X     X     X  X        X           X  X|     18     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Focal, Granulomatous   | 2                                                                        |      1  2.0|
      Necrosis                             |    3                                                        2     1      |      7  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                       +     +     +  +           +        +  +         |  14        |
      Fat, Angiectasis                     |                         3                                                |      4  2.8|
      Fat, Hemorrhage                      |                                                                          |      1  2.0|
      Fat, Inflammation, Chronic           |                               4     2  3                                 |      6  2.8|
      Fat, Necrosis                        |                                        3           3           3         |      5  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  47        |
      Acinus, Atrophy                      | 3                             3           1                          2   |      5  2.2|
      Acinus, Focal Cellular Change        |                                                          1               |      3  1.0|
      Acinus, Hyperplasia                  |                                                             1            |      1  1.0|
      Acinus, Inflammation, Chronic        |                                        3                             2   |      3  2.3|
      Duct, Cyst                           |                               X        X                                 |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +|  47        |
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                                 1                        |      1  1.0|
      Epithelium, Hyperplasia              |                            1                    1                    1   |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7|            |
                             DAY ON TEST   | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    20 PPM                                 | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|      L     |
                                           | 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
      Inflammation                         |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                2         |      1  2.0|
      Endothelium, Hyperplasia             |                                                                          |      1  1.0|
      Perivascular, Inflammation           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                               2                                          |      1  2.0|
      Hypertrophy                          |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  46        |
      Hyperplasia                          |                                        1                                 |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  +  +  M  M  +  +  M  +  M  +  +  +  M  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                        2                                 |      3  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           | 2        1                    2  2                                       |     10  1.6|
      Pars Intermedia, Hyperplasia         |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                    X                     |      1     |
      Inflammation                         |                                                                          |      2  2.0|
      Follicular Cell, Hyperplasia         |                   4  1                 4  1                 2  1     3  1|     13  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|  48        |
      Angiectasis                          |                   1                          2                          2|      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7|            |
                             DAY ON TEST   | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    20 PPM                                 | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|      L     |
                                           | 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |    2        2        2  2     2  1  2  2  2  2  3  3     3  3  2     3  3|     32  2.2|
      Cyst                                 |    X        X        X     X        X     X  X     X     X     X     X   |     19     |
      Germinal Epithelium, Hyperplasia     |                                        1  1  3                 1        2|      8  1.5|
      Granulosa Cell, Hyperplasia          |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      4                             3                    2|     10  3.1|
      Atrophy                              |                                                                          |      1  1.0|
      Hemorrhage                           |                                                    4                     |      2  4.0|
      Hyperplasia, Cystic                  | 2        2  1  1  2  2  2  2  1  1  1  1  2  2  2  2           2  1  2  3|     40  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Fibrosis                             |                                                                          |      1  1.0|
      Hyperplasia                          |                               2     2           2                        |      9  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Iliac, Hyperplasia                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +|  42        |
      Hyperplasia                          |                         2  4  2                          2     2         |      6  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Hyperplasia                          |                               2                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  M  M  +  M  +  +  M  +  M  +  +  +  +  +  M  M|  33        |
      Hyperplasia                          |                2                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                        1                 1               |      3  1.3|
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Hyperplasia                          |             1  2        2        2                 1           4         |      7  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |             2  2  1  1     2  3     1     1     2        3  2  2     2   |     24  2.1|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                   2                                                      |      2  2.0|
      Capsule, Inflammation, Chronic       |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  +  +  +  +|  45        |
      Angiectasis                          |                                                    2                     |      1  2.0|
      Hyperplasia, Lymphoid                |                   1           2              2                           |      3  1.7|
      Necrosis                             |    2                                            2                 4      |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7|            |
                             DAY ON TEST   | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    20 PPM                                 | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|      L     |
                                           | 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          |                   1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |          X                                                               |      1     |
      Necrosis                             |                                                                          |      1  3.0|
      Hair Follicle, Atrophy               |                                                                          |      2  2.5|
      Subcutaneous Tissue, Hemorrhage      |          1                                                               |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |          2  2     1     2     1  2  1  2  1  2  2  2        1  2     2  2|     29  1.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      3  1.7|
      Mineralization                       |       1     1     1           1           1  1     1           1     1   |     17  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |    3     3  2                       1                    1               |      6  2.2|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Thrombosis                           |          2                                                               |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                  1              1                        |      3  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |             4        2                       2           4     3         |      7  3.1|
      Alveolus, Pigmentation, Hemosiderin  |             4                                                  3         |      2  3.5|
      Fat, Mediastinum, Necrosis           |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                   1  1     1  1     1     1  1  1     1  1               |     13  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             2                                                  1         |      6  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |             1        1              1        1           1     1     1   |     14  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 3| 6| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 2| 7| 7|            |
                             DAY ON TEST   | 4| 9| 6| 0| 3| 8| 3| 7| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 4| 3| 0| 3| 7| 3| 3|            |
                                           | 1| 2| 5| 0| 4| 1| 4| 7| 4| 3| 4| 4| 6| 4| 4| 4| 5| 4| 9| 4| 4| 4| 2| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    20 PPM                                 | 8| 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|      L     |
                                           | 3| 4| 5| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   2        |
      Degeneration                         |             4                                                            |      1  4.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Hyperplasia                          |                            3  1                    4                 2   |      9  1.9|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Nephropathy                          |          1                       1                       1               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|             
                                           | 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|             
                                           | 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  M  A  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
      Inflammation                         |             2                          1                                 |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            2                                             |             
      Basophilic Focus                     |                                                    X                     |             
      Degeneration, Fatty                  |                2                       1              2        3         |             
      Eosinophilic Focus                   | X        X                 X                 X              X     X  X   |             
      Hematopoietic Cell Proliferation     |                            3     1        3                    2         |             
      Mixed Cell Focus                     |                                                             X            |             
      Necrosis                             |       3                                            1                     |             
      Biliary Tract, Cyst                  |                                                                          |             
      Biliary Tract, Hyperplasia           |             1                                                            |             
      Centrilobular, Degeneration, Fatty   |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                   +  +           +              +  +|             
      Fat, Angiectasis                     |                                        3                             1   |             
      Fat, Inflammation, Chronic           |    3                                                                    3|             
      Fat, Necrosis                        |    4                                                  2                 4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Focal Cellular Change        |                               1                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                            2                                             |             
      Inflammation                         |       1                    2                                2            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                        2                                 |             
      Epithelium, Hyperplasia              |                                        2        3                 1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Pigmentation, Hemosiderin            |       2                                                                  |             
      Ulcer                                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|             
                                           | 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|             
                                           | 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                    2              2      |             
      Mineralization                       |       1                                                                  |             
      Necrosis                             |                                                          1               |             
      Endothelium, Hyperplasia             |                                                                      2   |             
      Pericardium, Inflammation, Chronic   |                   1                                                      |             
      Pericardium, Fat, Necrosis           |                                                                          |             
      Perivascular, Inflammation           |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X     X                                   X   |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Hyperplasia                          | 2                                               2                        |             
      Hypertrophy                          | 1                                                                 1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  A  +  +  +  +  A  +  I  +  +  I  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  M  +  M  A  M  M  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           | 1  1                                   2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 4                                                                        |             
      Inflammation                         |             2                                                            |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         | 2        2                                                        1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2     2  3           3                                            4   |             
      Atrophy                              | 2  3  2  2     1  2        3  3  2  2     3  2     2  2  3  2  3  3  1  3|             
      Cyst                                 | X     X  X     X     X  X              X                       X  X      |             
      Germinal Epithelium, Hyperplasia     | 3                             2              1     3  2     2  1     1   |             
      Granulosa Cell, Hyperplasia          |    1           2                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1                       3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|             
                                           | 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|             
                                           | 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                            1                                             |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                      2   |             
      Hyperplasia, Cystic                  | 1  1  1  2  1  3  1     1        1     2     2  2  1  1  1  1  2  2  1  2|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |             2              3              2     2  2           3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  M  M  +  +  +  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Hyperplasia                          |                         3                                            4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  +  +  +  M  M  M  +  +  A  M  +  +  M  +  +  +  M  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             4                                      2                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2                       3                                         2  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             2           2  4     2     1  4     2  2     2     2  2  3   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  M  A  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Necrosis                             |       2     1     2  2     2                    1  1     2  2  2     1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |             1                                                            |             
      Hyperplasia                          |                                  2        4              1        2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hair Follicle, Atrophy               |                         2                                            1   |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|             
                                           | 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|             
                                           | 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 2  2  1  1              1     2        2  2     3  2  2  3  1  2  2      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1                                                                  |             
      Mineralization                       |       1              1  1              1     1     1              1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  I  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       3                                   2                              |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             2  2        2                    1     4  2     1            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2        2        3                                         1            |             
      Alveolus, Pigmentation, Hemosiderin  |                                                             1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1        1              1                 1           1     1        1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                             1        2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1        1     1                          1           2     1   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                  +               |             
      Cornea, Hyperplasia                  |                                                          2               |             
      Cornea, Inflammation, Chronic        |                                                          3               |             
      Lens, Degeneration                   |       3                                                  3               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                   3                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                            2                                             |             
      Nephropathy                          |          1  1     1                                                     1|             
      Pigmentation, Hemosiderin            |                                           2                       3      |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 6| 4| 5| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 4| 3| 5| 8| 3| 4| 6| 8| 5| 6| 3| 3| 2| 7| 4| 9| 1| 3| 8| 2| 3| 3| 4|             
                                           | 3| 0| 4| 3| 3| 5| 2| 9| 4| 6| 0| 5| 9| 3| 2| 0| 5| 8| 0| 9| 0| 5| 3| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    62.5 PPM                               | 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6|             
                                           | 1| 5| 1| 5| 1| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  I  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3|            |
                                           | 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    62.5 PPM                               | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2|      L     |
                                           | 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +|  43        |
      Hyperplasia                          |                      2                 1                                 |      3  1.7|
      Inflammation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2                          4|      3  2.7|
      Basophilic Focus                     |                                                                      X   |      2     |
      Degeneration, Fatty                  |                                                                          |      4  2.0|
      Eosinophilic Focus                   |    X                       1                    X                    X   |     11  1.0|
      Hematopoietic Cell Proliferation     |    3           1        1        1  3  3     1                           |     11  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             | 1                                2                             2         |      5  1.8|
      Biliary Tract, Cyst                  |                                                 X                        |      1     |
      Biliary Tract, Hyperplasia           |                                                                          |      1  1.0|
      Centrilobular, Degeneration, Fatty   |                   2                                                      |      1  2.0|
      Centrilobular, Necrosis              |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                         +                    +         |   9        |
      Fat, Angiectasis                     |                                                                3         |      3  2.3|
      Fat, Inflammation, Chronic           |                                                                          |      2  3.0|
      Fat, Necrosis                        |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Focal Cellular Change        |             1                                                  1         |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Inflammation                         |                1                                                         |      4  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ulcer                                |                                              1           1               |      3  1.3|
      Epithelium, Hyperplasia              |          3                       4           2           2               |      7  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                          1               |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3|            |
                                           | 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    62.5 PPM                               | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2|      L     |
                                           | 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                                                    2                     |      2  2.0|
      Ulcer                                |                                                    2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                          +               |   1        |
      Mineralization                       |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       |    1                             2                                       |      4  1.8|
      Mineralization                       |                                  1                                       |      2  1.0|
      Necrosis                             |                                           2                              |      2  1.5|
      Endothelium, Hyperplasia             |             2                       4  1                                 |      4  2.3|
      Pericardium, Inflammation, Chronic   |                                                                          |      1  1.0|
      Pericardium, Fat, Necrosis           |                                                    3                     |      1  3.0|
      Perivascular, Inflammation           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                  X                                       |      4     |
      Hematopoietic Cell Proliferation     |    3                                   2           2                     |      4  2.3|
      Hyperplasia                          |                                                                          |      2  2.0|
      Hypertrophy                          |                                                                         1|      3  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |    2                                                                 1   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Pars Distalis, Angiectasis           |                                  3                                       |      1  3.0|
      Pars Distalis, Hyperplasia           |    4                       1  1  3                    2              1   |      9  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                  X        X                          X   |      4  4.0|
      Inflammation                         |    2                                                                     |      2  2.0|
      C-Cell, Hyperplasia                  |                               1                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                 1              1     1   |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3|            |
                                           | 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    62.5 PPM                               | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2|      L     |
                                           | 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                   1     1  2           1     1  3  4                 4   |     13  2.4|
      Atrophy                              |    3  3     2  3  2  2  3  2  3  3  2  3  3  2  3  3  2  1  2     3  3  3|     42  2.4|
      Cyst                                 |    X              X           X        X  X     X              X     X   |     17     |
      Germinal Epithelium, Hyperplasia     |    2                       3  1  2  1                          3  1      |     15  1.9|
      Granulosa Cell, Hyperplasia          |       1                                                                  |      3  1.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                        4                    4  4         |      5  3.2|
      Atrophy                              |                                                                          |      1  1.0|
      Cyst                                 |                                                    X                     |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Cystic                  | 1  1  1  1  1  1  3  2  2  3        1  1  2  1  4  1  1  1     2        2|     40  1.5|
      Thrombosis                           |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |       +                       +                                   +      |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                      2                                                   |      1  2.0|
      Fibrosis                             |                      2                                                   |      1  2.0|
      Hyperplasia                          | 3  3  2     2           2     2     3  3  2  3        2        2         |     18  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|  38        |
      Hematopoietic Cell Proliferation     |                                  4                                       |      1  4.0|
      Hyperplasia                          |                      2                                                   |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +|  43        |
      Hematopoietic Cell Proliferation     |    2        2                                                            |      3  2.0|
      Hyperplasia                          |             2                             3                              |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M|  36        |
      Hematopoietic Cell Proliferation     | 1  3                             4                                       |      3  2.7|
      Hyperplasia                          |                      2  2                 2                              |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                           2     2                        |      4  2.5|
      Hematopoietic Cell Proliferation     |             1                    3              2                        |      3  2.0|
      Hyperplasia                          |                                                                      2  2|      6  2.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3|            |
                                           | 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    62.5 PPM                               | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2|      L     |
                                           | 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     | 3  4        2  3  2  1  1  2     4  3  3  2  2        2        2     2  2|     29  2.3|
      Hyperplasia, Lymphoid                |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  I  I  +  +  +  +|  41        |
      Hyperplasia, Lymphoid                |                                                       4                  |      2  3.0|
      Infiltration Cellular, Mixed Cell    |                                  4                                       |      1  4.0|
      Necrosis                             | 2                                   2        1     2           2         |     16  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hair Follicle, Atrophy               |                                                    3                     |      3  2.0|
      Subcutaneous Tissue, Hemorrhage      |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |       1                    2                    2  1  1              2  2|     22  1.8|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                             2  1         |      3  1.3|
      Mineralization                       |    1     1        1     1                    1                    1  1   |     14  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|  47        |
      Inflammation                         | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           | 2        2                          2                                    |      5  2.2|
      Inflammation, Chronic, Focal         |                                                       2                  |      1  2.0|
      Inflammation, Focal, Granulomatous   |          2                                                               |      1  2.0|
      Inflammation, Suppurative            | 1                                                                        |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                   2                                               2      |      9  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                      3  4                             2                  |      7  2.4|
      Alveolus, Pigmentation, Hemosiderin  |                                                       2                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1                 1  1           1                                    |     11  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 3| 6| 4| 6| 6| 7| 5| 7| 5| 5| 5| 4| 7| 5| 6| 3| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 8| 0| 9| 0| 4| 5| 2| 2| 6| 3| 9| 7| 9| 4| 3| 2| 5| 8| 0| 9| 3| 3| 3|            |
                                           | 8| 3| 5| 7| 2| 8| 3| 8| 5| 3| 9| 3| 4| 9| 7| 3| 3| 4| 3| 7| 7| 8| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    62.5 PPM                               | 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2|      L     |
                                           | 3| 5| 1| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1                                   1                                    |      4  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                         1              1           1                    1|     10  1.1|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Hyperplasia                  |                                                                          |      1  2.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
      Lens, Degeneration                   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    2                                                                 2   |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                          1               |      2  1.5|
      Nephropathy                          |                               2           2                              |      6  1.3|
      Pigmentation, Hemosiderin            |                                                                          |      2  2.5|
      Renal Tubule, Degeneration           |                                                          2               |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                       1                  |      1  1.0|
      Renal Tubule, Mineralization         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 3| 4| 4| 4| 6| 4| 5| 3| 5| 5| 5| 4| 4| 3| 5| 5| 6| 5| 4| 4| 4| 3|             
                             DAY ON TEST   | 6| 0| 6| 9| 7| 8| 5| 2| 6| 1| 7| 9| 9| 6| 1| 5| 5| 6| 6| 6| 0| 7| 8| 6| 7|             
                                           | 9| 2| 0| 3| 1| 5| 4| 9| 3| 3| 1| 7| 7| 9| 1| 4| 3| 9| 9| 3| 2| 2| 5| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4|             
                                           | 1| 3| 1| 2| 3| 5| 3| 4| 5| 1| 2| 3| 1| 2| 3| 5| 2| 3| 4| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Peyer's Patch, Hyperplasia           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              1                           |             
      Eosinophilic Focus                   |                                     X              X     X               |             
      Hematopoietic Cell Proliferation     |    1        1     1                    4     2           2  1            |             
      Necrosis                             | 2        2  1  1     3  2        1                 1           2  2  2   |             
      Thrombosis                           |                                                                          |             
      Biliary Tract, Cyst                  |                                                                          |             
      Centrilobular, Degeneration, Fatty   |                                                                          |             
      Centrilobular, Necrosis              |                                                          2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +              +        +              +  +        +      |             
      Fat, Angiectasis                     |                                                                          |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Inflammation, Chronic           |                3                       2                 3               |             
      Fat, Necrosis                        |                2              2        4                 3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                         1     1                                          |             
      Epithelium, Hyperplasia              |       1     1  3        1     1  1                          3        1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                3         |             
      Ulcer                                |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |                                        3                                 |             
      Mineralization                       |                            1                                   1         |             
      Necrosis                             |                                                                          |             
      Endothelium, Hyperplasia             | 2                 2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 3| 4| 4| 4| 6| 4| 5| 3| 5| 5| 5| 4| 4| 3| 5| 5| 6| 5| 4| 4| 4| 3|             
                             DAY ON TEST   | 6| 0| 6| 9| 7| 8| 5| 2| 6| 1| 7| 9| 9| 6| 1| 5| 5| 6| 6| 6| 0| 7| 8| 6| 7|             
                                           | 9| 2| 0| 3| 1| 5| 4| 9| 3| 3| 1| 7| 7| 9| 1| 4| 3| 9| 9| 3| 2| 2| 5| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4|             
                                           | 1| 3| 1| 2| 3| 5| 3| 4| 5| 1| 2| 3| 1| 2| 3| 5| 2| 3| 4| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Hematocyst                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2                    2                                 |             
      Hyperplasia                          |                                                 1                        |             
      Hypertrophy                          |                                  1                    1                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  +  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
      Follicular Cell, Hyperplasia         |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3  1                    2              1        1     4                  |             
      Atrophy                              | 2  2  3     3  3     3  3  3  3     2  3  3  2  3  3  3  3  3  3  3  3  3|             
      Cyst                                 |          X  X           X                       X              X         |             
      Germinal Epithelium, Hyperplasia     | 2           3  1           1     3        2  1        3                  |             
      Granulosa Cell, Hyperplasia          |    2                    2                                   1            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              | 2              1                                            1            |             
      Hyperplasia, Cystic                  |       1  2           2              1  1           1  2  2     1     1   |             
      Muscularis, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3     3  3  2  4                 3  3     3              2           2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  I  +  M  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 3| 4| 4| 4| 6| 4| 5| 3| 5| 5| 5| 4| 4| 3| 5| 5| 6| 5| 4| 4| 4| 3|             
                             DAY ON TEST   | 6| 0| 6| 9| 7| 8| 5| 2| 6| 1| 7| 9| 9| 6| 1| 5| 5| 6| 6| 6| 0| 7| 8| 6| 7|             
                                           | 9| 2| 0| 3| 1| 5| 4| 9| 3| 3| 1| 7| 7| 9| 1| 4| 3| 9| 9| 3| 2| 2| 5| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4|             
                                           | 1| 3| 1| 2| 3| 5| 3| 4| 5| 1| 2| 3| 1| 2| 3| 5| 2| 3| 4| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                        2     2                           |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  I  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |          2                                         3                    2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Angiectasis                          |                                                                   2      |             
      Hematopoietic Cell Proliferation     |                                        4                                 |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                                                          3               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  3     2  2     2  2              2  4     3           2  3  3  2      |             
      Necrosis                             |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +|             
      Infiltration Cellular, Mixed Cell    |                                        4                                 |             
      Necrosis                             |       2  2     1        3     2     2              2  2  2     2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                      1              2                 2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     3                                    |             
      Necrosis                             |                                                                      2   |             
      Subcutaneous Tissue, Hemorrhage      |                                                       2                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    1           1     1              1                 2           1      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1                                                                        |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                               1                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 3| 4| 4| 4| 6| 4| 5| 3| 5| 5| 5| 4| 4| 3| 5| 5| 6| 5| 4| 4| 4| 3|             
                             DAY ON TEST   | 6| 0| 6| 9| 7| 8| 5| 2| 6| 1| 7| 9| 9| 6| 1| 5| 5| 6| 6| 6| 0| 7| 8| 6| 7|             
                                           | 9| 2| 0| 3| 1| 5| 4| 9| 3| 3| 1| 7| 7| 9| 1| 4| 3| 9| 9| 3| 2| 2| 5| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4|             
                                           | 1| 3| 1| 2| 3| 5| 3| 4| 5| 1| 2| 3| 1| 2| 3| 5| 2| 3| 4| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 3        2                                            2                  |             
      Infiltration Cellular, Mixed Cell    |                   2                                                      |             
      Inflammation, Chronic, Diffuse       |                                                       2                  |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Suppurative            |                                        1                                 |             
      Alveolar Epithelium, Hyperplasia     |    1                 1           2           1  1                    2   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2                                3                 3  3  3  3           3|             
      Alveolus, Pigmentation, Hemosiderin  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     1              1        1            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                1                                                         |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                1     1                             1  1     1            |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Cornea, Hyperplasia                  |                3                                                         |             
      Cornea, Inflammation, Chronic        |                2                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1     1  1                          1                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hydronephrosis                       |                                  2                                3      |             
      Infarct                              |                                                                   3      |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                   1                                         1            |             
      Nephropathy                          |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                      1   |             
      Medulla, Congestion                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3|            |
                             DAY ON TEST   | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4|            |
                                           | 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    200 PPM                                | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  A|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | I  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  M  A  +  +  +  +  A  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | I  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  45        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                      X                                         X         |      5     |
      Hematopoietic Cell Proliferation     |    1     2              3        4                       1     4        4|     14  2.2|
      Necrosis                             | 3        2  3                 1     3     1                       2     2|     19  1.9|
      Thrombosis                           |    3                                                                     |      1  3.0|
      Biliary Tract, Cyst                  |                                                             X            |      1     |
      Centrilobular, Degeneration, Fatty   |    2                                                                     |      1  2.0|
      Centrilobular, Necrosis              |    1                       2                       3                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +  +                       +           +                     |  12        |
      Fat, Angiectasis                     |                4                                                         |      1  4.0|
      Fat, Hemorrhage                      |             2                                                            |      1  2.0|
      Fat, Inflammation, Chronic           |                4                       3                                 |      5  3.0|
      Fat, Necrosis                        |    2                                   4                                 |      6  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                1                                      2                  |      2  1.5|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                               1     2                          2         |      5  1.4|
      Epithelium, Hyperplasia              | 2                             1     1           1     3        2         |     14  1.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pigmentation, Hemosiderin            | 2           2                                      2                    1|      5  2.0|
      Ulcer                                | 2  1        2                                      2                    2|      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3|            |
                             DAY ON TEST   | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4|            |
                                           | 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    200 PPM                                | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  1.0|
      Necrosis                             |    2                                                                     |      1  2.0|
      Endothelium, Hyperplasia             |    1                                         4                 3         |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Hematocyst                           |                                           X                              |      1     |
      Hematopoietic Cell Proliferation     |          2                                               3        1      |      5  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Hypertrophy                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  I  +  M  +  +  +  +  +  M  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Pars Distalis, Cyst                  |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2           2        2  3     1           2        2                 4|     14  2.1|
      Atrophy                              | 3  3     3  3  3        3  3  3  3  3  2  3  2  3  3  2  3     2  3  3  2|     43  2.8|
      Cyst                                 |                X              X     X           X                        |      9     |
      Germinal Epithelium, Hyperplasia     | 1  2                    3        3              2              1         |     14  2.0|
      Granulosa Cell, Hyperplasia          |             3                                                            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      4                 4                                 |      2  4.0|
      Atrophy                              | 2  2                                                  1  1     1         |      8  1.4|
      Hyperplasia, Cystic                  |          1     2     3     1              1  1     1        1            |     18  1.4|
      Muscularis, Hyperplasia              |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3|            |
                             DAY ON TEST   | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4|            |
                                           | 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    200 PPM                                | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          4              2        3        2              4  2  3         |     17  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Renal, Hyperplasia                   |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  M  +  M  +  M  +  M  +  M  +  M  M  +  +  +  +  +  +  +|  34        |
      Congestion                           |                                                                         3|      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                4         |      2  3.5|
      Hyperplasia                          |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  I  M  +  +  M  +  +|  39        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M|  40        |
      Congestion                           |                      4                                                   |      1  4.0|
      Hematopoietic Cell Proliferation     |          3                                                     3         |      2  3.0|
      Hyperplasia                          |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                         3|      2  3.5|
      Hyperplasia                          |                                                                2         |      1  2.0|
      Inflammation, Granulomatous          |                                                       4                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   4      |      1  4.0|
      Hematopoietic Cell Proliferation     |    2     4           2  3        2     2  2              4  2  3     2  2|     25  2.5|
      Necrosis                             |          2                                                               |      1  2.0|
      Capsule, Inflammation, Chronic       |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  I  +  +  +|  40        |
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  4.0|
      Necrosis                             | 2  2        2     3  1  1  2                       2  2           3     2|     21  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |          1                          2              2        1            |      7  1.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                             4            |      2  3.5|
      Necrosis                             |                                                                          |      1  2.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                        4                                 |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3|            |
                             DAY ON TEST   | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4|            |
                                           | 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    200 PPM                                | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                1     2                 2           1  1                  |     11  1.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |             1                                                            |      2  1.0|
      Mineralization                       |                               1  1     1                       1        1|      5  1.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |    1     2  2                 2  1  2                                   2|     10  1.9|
      Infiltration Cellular, Mixed Cell    |                                  2                                       |      2  2.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                    2                     |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |    2        1                                   2              4        1|     11  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                4     3                       2                           |     10  2.9|
      Alveolus, Pigmentation, Hemosiderin  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                            1                 1        1                 2|      7  1.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                       1                  |      1  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |       1                                                                 1|      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                         1              1              1                  |      8  1.0|
      Metaplasia, Squamous                 |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +                       +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                            +            |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 5| 5| 6| 0| 7| 5| 4| 4| 4| 4| 6| 3| 4| 3| 5| 5| 2| 5| 4| 3| 3| 3|            |
                             DAY ON TEST   | 0| 1| 0| 2| 3| 2| 0| 0| 0| 8| 3| 4| 7| 9| 7| 7| 8| 4| 0| 6| 6| 8| 4| 1| 4|            |
                                           | 8| 8| 5| 4| 2| 4| 9| 4| 9| 4| 6| 6| 0| 5| 0| 8| 6| 3| 9| 8| 9| 9| 3| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    200 PPM                                | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 3| 4| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 5| 2| 3| 4| 1| 2| 3| 4| 5| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cornea, Hyperplasia                  |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic        |                                                             1            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                 4                        |      1  4.0|
      Hematopoietic Cell Proliferation     |                                  2                                      2|      2  2.0|
      Hydronephrosis                       |                                                                          |      2  2.5|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                            1                                             |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Nephropathy                          |                                                 2                        |      1  2.0|
      Capsule, Inflammation, Chronic       |                                                                          |      1  1.0|
      Medulla, Congestion                  |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 2| 3| 2| 2| 2| 1| 3|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 9| 2| 1| 1| 3| 8| 2| 0| 8| 1| 4| 7| 0| 8| 0| 8| 5| 8| 3|             
                                           | 3| 0| 7| 4| 5| 7| 8| 8| 7| 9| 1| 0| 9| 7| 7| 9| 3| 9| 5| 5| 3| 5| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  A  A  +  +  +  +  A  +  A  +  +  +  +  +  +  M  +  +  +  +  A  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                   1                    1           2                     |             
      Inflammation, Chronic                |                                                                          |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis                             | 1                       2        2  2        2        1                  |             
      Thrombosis                           |                                                                          |             
      Biliary Tract, Cyst                  |                                                                          |             
      Centrilobular, Degeneration, Fatty   |                                     3                                   3|             
      Centrilobular, Necrosis              |                   1                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                             +        +               |             
      Fat, Inflammation, Chronic           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Ulcer                                |                               1        2                                 |             
      Epithelium, Hyperplasia              | 3     3     2  2        2  3  2        2     2     3     3  2  1  2     2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  A  +|             
      Hemorrhage                           |       2                                                                  |             
      Pigmentation, Hemosiderin            |          1                                                               |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                                                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 2| 3| 2| 2| 2| 1| 3|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 9| 2| 1| 1| 3| 8| 2| 0| 8| 1| 4| 7| 0| 8| 0| 8| 5| 8| 3|             
                                           | 3| 0| 7| 4| 5| 7| 8| 8| 7| 9| 1| 0| 9| 7| 7| 9| 3| 9| 5| 5| 3| 5| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |             1                       1                          1  1      |             
      Necrosis                             |                                                       2                  |             
      Atrium, Thrombosis                   |                                                                          |             
      Endothelium, Hyperplasia             |                         4     4                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  M  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +|             
      Pars Distalis, Cyst                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Follicular Cell, Hyperplasia         |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Angiectasis                          | 3  1                          1        2                                 |             
      Atrophy                              | 2        2  2  3  3     2  3  2  3  3  2  3  3  3  3  2  3  2     3     3|             
      Cyst                                 |                                     X           X  X           X         |             
      Germinal Epithelium, Hyperplasia     | 1                    3        1        1                                 |             
      Granulosa Cell, Hyperplasia          | 2              1                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Atrophy                              |       2     2  2  1  2  2        1  2  2                 2  1  2  1      |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Atrophy                              |             4                    4                    4                 4|             
      Hyperplasia                          |                   3                    2  3     3  3     2               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  M  +  M  +  +  M  +  +  M  M  M  M  M  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 2| 3| 2| 2| 2| 1| 3|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 9| 2| 1| 1| 3| 8| 2| 0| 8| 1| 4| 7| 0| 8| 0| 8| 5| 8| 3|             
                                           | 3| 0| 7| 4| 5| 7| 8| 8| 7| 9| 1| 0| 9| 7| 7| 9| 3| 9| 5| 5| 3| 5| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  M  +  +  I  +  I  +  +  I  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                         2|             
      Hyperplasia, Plasma Cell             |                                  3                                       |             
      Necrosis                             |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  M  +  +  +  +  A  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                          1               |             
      Hyperplasia, Histiocytic             |                                                                         2|             
      Inflammation                         |                                                          2               |             
      Necrosis                             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                   3  2        2  2     3  3     2  2                     |             
      Hyperplasia, Histiocytic             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Necrosis                             |                         2        2     1        2     2  2              2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periosteum, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       2                                                              2   |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Mineralization                       |                      1                 1  1                             1|             
      Thrombosis                           |                                                                          |             
      Ventricle, Cyst Epithelial Inclusion |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                            +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 2| 3| 2| 2| 2| 1| 3|             
                             DAY ON TEST   | 5| 4| 0| 9| 7| 1| 9| 2| 1| 1| 3| 8| 2| 0| 8| 1| 4| 7| 0| 8| 0| 8| 5| 8| 3|             
                                           | 3| 0| 7| 4| 5| 7| 8| 8| 7| 9| 1| 0| 9| 7| 7| 9| 3| 9| 5| 5| 3| 5| 9| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hemorrhage                           |                         2     1              2     3              1      |             
      Infiltration Cellular, Mixed Cell    |                      1                                                   |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2                             2                 2                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Pyogranulomatous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Atrophy        |       2     3                                                  4         |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  I  I  +|             
      Hyperplasia                          |                      1                          1                       1|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |       3                                                                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2| 4| 3| 3| 3|             
                             DAY ON TEST   | 2| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7| 0| 8| 4| 3|             
                                           | 5| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5| 1| 7| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  I  A  +  +  I  +  +  +  A  +  A  +  +  A  +  A  A  A  +  +  +  +  M  +|             
      Inflammation                         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  A  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  M  +  +  A  +  A  +  A  +  A  +  +  A  +  +  A  +  +  +  +  +  A  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                      X                                            X      |             
      Hematopoietic Cell Proliferation     |                   2                                                  1   |             
      Inflammation, Chronic                |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |    2  2                 3     2  3     1           4                     |             
      Thrombosis                           |                               3                                          |             
      Biliary Tract, Cyst                  |             X                 X                                          |             
      Centrilobular, Degeneration, Fatty   |                                                                          |             
      Centrilobular, Necrosis              |                                           3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Fat, Inflammation, Chronic           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                | 1           1        1     1                                             |             
      Epithelium, Hyperplasia              | 2  2  2  2  4     3  3  2  2        2  1  2  1  2        1        2     1|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                    2                     |             
      Ulcer                                |                                                    1                     |             
      Epithelium, Hyperplasia              | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1                                      3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2| 4| 3| 3| 3|             
                             DAY ON TEST   | 2| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7| 0| 8| 4| 3|             
                                           | 5| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5| 1| 7| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                        1           1                     |             
      Necrosis                             |                                        2                                 |             
      Atrium, Thrombosis                   |                                                                          |             
      Endothelium, Hyperplasia             |             1                 1                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Hemorrhage                           |       2                                                                  |             
      Hyperplasia                          |       1                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                             1        4              1     2  1         |             
      Atrophy                              | 3  3  3  3  3  2  3  3  3  2  2  2  2  2  3  3  3  4  3  2     3  3  3  3|             
      Cyst                                 |          X              X        X                 X  X              X   |             
      Germinal Epithelium, Hyperplasia     |                   2     1                 1     3                       1|             
      Granulosa Cell, Hyperplasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  2  1  2                 1           3  1  1     2  2  2        1  2  2|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                                   4                                 |             
      Hyperplasia                          |             3     4           2                                3  2      |             
      Necrosis                             |                                                       2  2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2| 4| 3| 3| 3|             
                             DAY ON TEST   | 2| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7| 0| 8| 4| 3|             
                                           | 5| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5| 1| 7| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  M  M  I  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Hyperplasia, Histiocytic             |    2                                                                     |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           3                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |    2                                                                     |             
      Hematopoietic Cell Proliferation     |    2  2     2     4           2                 2                 2  3   |             
      Hyperplasia, Histiocytic             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |    2                          2           2     2              2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periosteum, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1                                                                  |             
      Infiltration Cellular, Mixed Cell    |                                                                      2   |             
      Mineralization                       |       1                                                        1     1   |             
      Thrombosis                           |                                                                          |             
      Ventricle, Cyst Epithelial Inclusion |                                                             X            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                   +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 2| 3| 2| 4| 3| 3| 3| 3| 2| 3| 3| 2| 3| 4| 2| 3| 3| 2| 2| 2| 4| 3| 3| 3|             
                             DAY ON TEST   | 2| 8| 6| 9| 4| 1| 3| 8| 7| 3| 9| 5| 2| 0| 5| 5| 7| 6| 8| 8| 7| 0| 8| 4| 3|             
                                           | 5| 9| 9| 8| 1| 1| 5| 4| 1| 0| 7| 0| 2| 0| 0| 7| 6| 6| 5| 3| 5| 1| 7| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    625 PPM                                | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +  +  I  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  I  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    1                     |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       2                       3                    3                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2                                         3                              |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Pyogranulomatous                 |                                              1                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                           1                              |             
      Olfactory Epithelium, Atrophy        |                                              3           4               |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                         3                     |             
      Inflammation, Chronic                |                                                                         3|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                       +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                                                                          |             
      Metaplasia, Osseous                  |                   1                                                      |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 0| 3| 2| 3| 2| 4| 3| 2| 4| 4| 2| 3| 3| 3| 3| 3| 2| 3| 4| 2| 3| 3|             
                             DAY ON TEST   | 8| 7| 2| 1| 9| 8| 0| 4| 2| 5| 5| 2| 1| 9| 2| 7| 6| 1| 5| 5| 1| 1| 3| 7| 1|             
                                           | 5| 2| 1| 1| 2| 0| 0| 6| 5| 6| 3| 5| 8| 6| 9| 3| 7| 6| 7| 7| 6| 8| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 2| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  A  A  +  +  A  A  +  A  A  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  A  A  +  +  A  A  +  A  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  A  A  +  A  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  A  +  A  A  +  A  A  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           1                          2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                         X|             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2                                   1        1     1   |             
      Inflammation, Chronic                |                                                                   2      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                     3                          2     2   |             
      Thrombosis                           |                                                                          |             
      Biliary Tract, Cyst                  |                                                                          |             
      Centrilobular, Degeneration, Fatty   |    2                                                                     |             
      Centrilobular, Necrosis              | 2  2        3                          2                          2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Fat, Inflammation, Chronic           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                  2  2        1  2                        |             
      Epithelium, Hyperplasia              |    1  1        1  2              3  3     1        2  4  1  2           2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            |    2                                2                                    |             
      Ulcer                                |    2                                                                     |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 0| 3| 2| 3| 2| 4| 3| 2| 4| 4| 2| 3| 3| 3| 3| 3| 2| 3| 4| 2| 3| 3|             
                             DAY ON TEST   | 8| 7| 2| 1| 9| 8| 0| 4| 2| 5| 5| 2| 1| 9| 2| 7| 6| 1| 5| 5| 1| 1| 3| 7| 1|             
                                           | 5| 2| 1| 1| 2| 0| 0| 6| 5| 6| 3| 5| 8| 6| 9| 3| 7| 6| 7| 7| 6| 8| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 2| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       | 2  1                                      1              2        2      |             
      Necrosis                             |                                                             1            |             
      Atrium, Thrombosis                   |    2                                                              4      |             
      Endothelium, Hyperplasia             |                                  1  2                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  I  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  I|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2     3  2              3        1        2                        |             
      Atrophy                              | 3  3  2     3  3  2     3  3  3  3  4  2     3  3  3  3  3     2  3  3  3|             
      Cyst                                 |                X                 X                    X                  |             
      Germinal Epithelium, Hyperplasia     |             2           2  2     2  2           2                    1   |             
      Granulosa Cell, Hyperplasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  2           2  1     2        2        1              1  1  1     2|             
      Cyst                                 |                                                 X                        |             
      Hyperplasia, Histiocytic             |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    M                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3                                   4  3                       3      |             
      Hyperplasia                          |                                  1           2        2        2     3   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  M  +  M  M  +  M  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 0| 3| 2| 3| 2| 4| 3| 2| 4| 4| 2| 3| 3| 3| 3| 3| 2| 3| 4| 2| 3| 3|             
                             DAY ON TEST   | 8| 7| 2| 1| 9| 8| 0| 4| 2| 5| 5| 2| 1| 9| 2| 7| 6| 1| 5| 5| 1| 1| 3| 7| 1|             
                                           | 5| 2| 1| 1| 2| 0| 0| 6| 5| 6| 3| 5| 8| 6| 9| 3| 7| 6| 7| 7| 6| 8| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 2| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +  M  +  +  M  +  A  +  M  +  M  I  +  +  +  +  I  +|             
      Hyperplasia, Histiocytic             |                                                                   3      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +|             
      Congestion                           | 2           3           2                                                |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  I  +  +  A  +  +  +  +  +  +  +  +  M  M  +|             
      Congestion                           | 3                                                                        |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |             1  2           2              2  2        3        1     3   |             
      Hyperplasia, Histiocytic             |                                                                   4      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  M  +  +  +  +  +  +|             
      Necrosis                             |    2        2           2           2        2  2              2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemorrhage      |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periosteum, Hemorrhage               | 3                                                                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +                                 |             
      Hemorrhage                           |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                             1                                 |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Mineralization                       |                         1        1        1                             1|             
      Thrombosis                           |                      2                                                   |             
      Ventricle, Cyst Epithelial Inclusion |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                    +                             +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 0| 3| 2| 3| 2| 4| 3| 2| 4| 4| 2| 3| 3| 3| 3| 3| 2| 3| 4| 2| 3| 3|             
                             DAY ON TEST   | 8| 7| 2| 1| 9| 8| 0| 4| 2| 5| 5| 2| 1| 9| 2| 7| 6| 1| 5| 5| 1| 1| 3| 7| 1|             
                                           | 5| 2| 1| 1| 2| 0| 0| 6| 5| 6| 3| 5| 8| 6| 9| 3| 7| 6| 7| 7| 6| 8| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    625 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 2| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  A  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2        1  1        1           2           1                  |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Thrombosis                           |                      3                                                   |             
      Alveolar Epithelium, Hyperplasia     |                                     1                 4        2        1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                  3                                       |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Pyogranulomatous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Atrophy        | 4                 3                                                      |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +|             
      Hyperplasia                          |                                  4                                       |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Thrombosis                           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1                                                                        |             
      Hyperplasia, Histiocytic             |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 2| 2| 3|                                                           |            |
                             DAY ON TEST   | 8| 1| 3| 8| 6|                                                           |            |
                                           | 5| 8| 2| 0| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7|                                                           |      A     |
    625 PPM                                | 5| 6| 6| 6| 6|                                                           |      L     |
                                           | 5| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +                                                            |  79        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +                                                            |  55        |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +                                                            |  77        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +                                                            |  68        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  73        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +                                                            |  73        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +                                                            |  70        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +                                                            |  62        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +                                                            |  66        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  60        |
      Hemorrhage                           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  80        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Hematopoietic Cell Proliferation     | 2                                                                        |     10  1.4|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |    2                                                                     |     17  2.1|
      Thrombosis                           |                                                                          |      1  3.0|
      Biliary Tract, Cyst                  |                                                                          |      2     |
      Centrilobular, Degeneration, Fatty   |                                                                          |      3  2.7|
      Centrilobular, Necrosis              |                                                                          |      7  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   6        |
      Fat, Inflammation, Chronic           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  78        |
      Acinus, Atrophy                      |             1                                                            |      1  1.0|
      Duct, Cyst                           | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  79        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +                                                            |  79        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  79        |
      Ulcer                                |       1                                                                  |     11  1.4|
      Epithelium, Hyperplasia              | 2     2     3                                                            |     47  2.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  76        |
      Hemorrhage                           |          1                                                               |      2  1.5|
      Pigmentation, Hemosiderin            |                                                                          |      4  1.8|
      Ulcer                                |                                                                          |      2  1.5|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 2| 2| 3|                                                           |            |
                             DAY ON TEST   | 8| 1| 3| 8| 6|                                                           |            |
                                           | 5| 8| 2| 0| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7|                                                           |      A     |
    625 PPM                                | 5| 6| 6| 6| 6|                                                           |      L     |
                                           | 5| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  80        |
      Cardiomyopathy                       |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |     11  1.3|
      Necrosis                             |                                                                          |      3  1.7|
      Atrium, Thrombosis                   |                                                                          |      2  3.0|
      Endothelium, Hyperplasia             | 2  3                                                                     |      8  2.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +                                                            |  78        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +                                                            |  78        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +                                                            |  76        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  78        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  69        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  71        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  78        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |  79        |
      Angiectasis                          | 4                                                                        |     17  2.1|
      Atrophy                              | 3  4  3     3                                                            |     69  2.8|
      Cyst                                 |                                                                          |     13     |
      Germinal Epithelium, Hyperplasia     | 1           1                                                            |     18  1.6|
      Granulosa Cell, Hyperplasia          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |  78        |
      Atrophy                              |    2     2                                                               |     41  1.7|
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 2| 2| 3|                                                           |            |
                             DAY ON TEST   | 8| 1| 3| 8| 6|                                                           |            |
                                           | 5| 8| 2| 0| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7|                                                           |      A     |
    625 PPM                                | 5| 6| 6| 6| 6|                                                           |      L     |
                                           | 5| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Histiocytic             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  79        |
      Atrophy                              |                                                                          |     11  3.7|
      Hyperplasia                          | 3  3                                                                     |     18  2.6|
      Necrosis                             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +                                                            |  79        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +                                                            |  54        |
      Congestion                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +                                                            |  58        |
      Hyperplasia, Histiocytic             |                                                                          |      3  2.3|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |  67        |
      Congestion                           |                                                                          |      4  2.5|
      Hematopoietic Cell Proliferation     |    2                                                                     |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  71        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  78        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 3  2                                                                     |     26  2.3|
      Hyperplasia, Histiocytic             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |  71        |
      Necrosis                             |    2        2                                                            |     23  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +                                                            |  77        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  79        |
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 2| 2| 3|                                                           |            |
                             DAY ON TEST   | 8| 1| 3| 8| 6|                                                           |            |
                                           | 5| 8| 2| 0| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7|                                                           |      A     |
    625 PPM                                | 5| 6| 6| 6| 6|                                                           |      L     |
                                           | 5| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  80        |
      Periosteum, Hemorrhage               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  80        |
      Hemorrhage                           |                                                                          |      5  1.6|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |     11  1.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Ventricle, Cyst Epithelial Inclusion |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   9        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |  72        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  78        |
      Hemorrhage                           |                                                                          |     12  1.5|
      Infiltration Cellular, Mixed Cell    | 2  2                                                                     |      3  1.7|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |          2                                                               |     11  2.2|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  2.7|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Pyogranulomatous                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  79        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      7  3.3|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  73        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  +  +                                                            |  66        |
      Hyperplasia                          |             2                                                            |      7  1.9|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 2| 2| 3|                                                           |            |
                             DAY ON TEST   | 8| 1| 3| 8| 6|                                                           |            |
                                           | 5| 8| 2| 0| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7|                                                           |      A     |
    625 PPM                                | 5| 6| 6| 6| 6|                                                           |      L     |
                                           | 5| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  80        |
      Glomerulosclerosis                   |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +                                                            |  75        |
      Hemorrhage                           |          2  1                                                            |      3  1.3|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 9| 3|             
                                           | 6| 6| 6| 6| 6| 7| 6| 1| 2| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 7| 7| 8|             
                                           | 1| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 3| 5| 2| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Peyer's Patch, Hyperplasia           |                                                             4            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Inflammation,         |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                X         |             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                               X                                          |             
      Infarct                              |                         4                                                |             
      Inflammation, Chronic                |                                                                          |             
      Mixed Cell Focus                     | X                                                                        |             
      Necrosis                             |                                                                          |             
      Centrilobular, Degeneration, Fatty   |                                           1                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +     +                                +         |             
      Fat, Angiectasis                     |                         4                                                |             
      Fat, Inflammation, Granulomatous     |                                                                          |             
      Fat, Necrosis                        |                                                                2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  |                                  2                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Mast Cell               |                      1                                                   |             
      Ulcer                                |                                              2                           |             
      Epithelium, Hyperplasia              |                                              3                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                1     1                                                   |             
      Ulcer                                |                1     2                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +  +     +                       +         |             
      Inflammation                         |                               1  2     1                       2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 9| 3|             
                                           | 6| 6| 6| 6| 6| 7| 6| 1| 2| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 7| 7| 8|             
                                           | 1| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 3| 5| 2| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2     1                                                            |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |    1  1                          2                                       |             
      Hyperplasia                          |                            2                       2                     |             
      Hypertrophy                          |             2                          1              1     1  2  1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  +  +  I  +  +  +  +  M  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Muscularis, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                         +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +                                            +        +  +|             
      Degeneration, Cystic                 |                                                             2            |             
      Hyperplasia                          |                                                                      3   |             
      Inflammation, Suppurative            |                3                                            3        3  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              2                           |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                 2     2                                   1        3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 9| 3|             
                                           | 6| 6| 6| 6| 6| 7| 6| 1| 2| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 7| 7| 8|             
                                           | 1| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 3| 5| 2| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                        1                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  M  M  M  +  +  +  M  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                     2                                2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  M  M  +  M  +  M  +  M  +  M  M  M  +  +  +  +  M  M|             
      Hyperplasia                          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Congestion                           |       2        3                                                         |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                        2              2     2     2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2                 2              2                             2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |    1           1  2  2  2                    3                       2   |             
      Epithelial Cell, Hyperplasia         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  M  +  M  M  M  M  M  M  M  +  M  M  I  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Inflammation, Suppurative   |                                                                      4   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Pyogranulomatous                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                          X               |             
      Mineralization                       | 1  1        1              1  1  1  1           1  1  1     1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                             |             
      Inflammation, Chronic, Diffuse       |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 6| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 9| 3|             
                                           | 6| 6| 6| 6| 6| 7| 6| 1| 2| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 7| 7| 8|             
                                           | 1| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 3| 5| 2| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                              2                           |             
      Alveolar Epithelium, Hyperplasia     |                                        2                                 |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2     2                             4              2              1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1        1  2  1  1           1     1  1     1           1     1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                      2  1                                                |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                         1                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1  1     1  1  1  1                 1  1  1  1        1  1  1     1     1|             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Lens, Degeneration                   |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +                    +                                                   |             
      Cyst                                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                                        |             
      Hyperplasia, Mast Cell               |                      1                                                   |             
      Inflammation, Suppurative            |                                                                      2   |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1  1  2  1  1     1     1  1  1  1  1     1     1        1     1  1      |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Hyperplasia            |          4                                                               |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                3                                                     3  3|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ulcer                                |                                        2                                 |      1  2.0|
      Peyer's Patch, Hyperplasia           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Peyer's Patch, Inflammation,         |                                                                          |            |
          Granulomatous                    |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X                          X                                       |      3     |
      Clear Cell Focus                     |                                                             X            |      2     |
      Eosinophilic Focus                   |                                                                      X  X|      3     |
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                2                                                         |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |    3           2              3        1                                 |      4  2.3|
      Centrilobular, Degeneration, Fatty   |                      1                          1  1                     |      4  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                    +                             +      |   6        |
      Fat, Angiectasis                     |                                                                          |      1  4.0|
      Fat, Inflammation, Granulomatous     |                                     4                                    |      1  4.0|
      Fat, Necrosis                        |                                                                   3      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Mast Cell               |                                                                          |      1  1.0|
      Ulcer                                | 2                             2                                          |      3  2.0|
      Epithelium, Hyperplasia              | 2              2              1                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation, Hemosiderin            |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |       1                                                                  |      3  1.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                    +                 +              +     +      |   9        |
      Inflammation                         |       3                    2                 2              2     2      |      9  1.9|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                1  3                                                      |      4  1.8|
      Atrium, Thrombosis                   |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Focal Cellular Change                |                                  1                          1  1         |      6  1.2|
      Hyperplasia                          |                                              2           2  2  2         |      6  2.0|
      Hypertrophy                          | 2     1                 1  1        1                 1              2  1|     16  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                      1   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M|  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         2                                                |      1  2.0|
      Inflammation                         |                1                    1                                    |      2  1.0|
      Follicular Cell, Hyperplasia         |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                     3                                    |      1  3.0|
      Muscularis, Hyperplasia              |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |          +                                +              +               |   4        |
      Inflammation, Suppurative            |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  M                          +                    +               |   7        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          |       2                                                                  |      2  2.5|
      Inflammation, Suppurative            |                                     2                    1               |      6  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            | 2                                      2                                 |      3  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 2                                      1                                 |      3  1.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                               1                                          |      1  1.0|
      Degeneration                         |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  1        3              2  1  2     1                              |     13  1.8|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +|  39        |
      Hyperplasia                          |             2              1     2                                       |      5  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  M  +  +  +  +  +  M  M  M  +  M  +  M  +  M  M  +  +  M  M  +  +|  28        |
      Hyperplasia                          |             2     2                                                      |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                4                                                         |      2  3.0|
      Congestion                           |             2                       3                                    |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                        3                                 |      1  3.0|
      Hyperplasia                          |    2        2  3                    2                 1           1     2|     11  1.9|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                3                 1  2  2  1              2               |     10  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  I  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Necrosis                             | 1  2     3     2  3                             1                        |     13  1.9|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M|   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prepuce, Inflammation, Suppurative   |                                           3                              |      2  3.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                     4                                    |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Pyogranulomatous                |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                               +                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                                                          |      1     |
      Mineralization                       |    2  1                 1     1  1  1        1     1  1  1  1  1     1  1|     29  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                           1  1                    1      |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic, Diffuse       |                   3                                                      |      2  3.5|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                           2                              |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       1                       2           3           2  3               |     10  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |             1           1  1              1  1        1        1  1      |     19  1.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1              1     1           1     1        1  1        1  1      |     24  1.0|
      Metaplasia, Squamous                 |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
      Cornea, Inflammation, Chronic        | 2                                                                        |      1  2.0|
      Lens, Degeneration                   | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 7| 5| 5| 3| 7| 7| 5| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 0| 3| 9| 3| 7| 4| 7| 3| 3| 9| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 4| 9| 6| 5| 6| 2| 3| 9| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      L     |
                                           | 3| 4| 1| 2| 5| 1| 4| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       X     X                       X                                    |      4     |
      Hyperplasia, Mast Cell               |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |    1                                                                     |      1  1.0|
      Nephropathy                          | 2  2  1                       2  1  1  3     2     1  1     1  1  1  1  1|     31  1.2|
      Papilla, Necrosis                    | 3                                                                        |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                    2                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                           +                              |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |          4                          3  4  1  2           3               |      9  2.9|
      Inflammation                         | 1                                                                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 2| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 7| 5| 6| 4| 5| 5| 5| 5| 5| 5| 3| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6.25 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 4| 5| 1| 2| 3| 4| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                                      |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |       4                                            4                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |       4                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                      1           2   |             
      Basophilic Focus                     |                                  X                                       |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |             1  1                                1                        |             
      Eosinophilic Focus                   |       X              X                                         X     X   |             
      Inflammation, Chronic                |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |    2                                                                     |             
      Centrilobular, Degeneration, Fatty   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Angiectasis                     |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Angiectasis                  |                                                                          |             
      Acinus, Focal Cellular Change        |                      1                                                   |             
      Acinus, Necrosis                     |                                                 1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Hemosiderin            |                            2                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +        +                                                |             
      Inflammation                         |                2        1                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 2| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 7| 5| 6| 4| 5| 5| 5| 5| 5| 5| 3| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6.25 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 4| 5| 1| 2| 3| 4| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Endothelium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Focal Cellular Change                |                      2           1                    1        1         |             
      Hyperplasia                          |                               1           3              2  1            |             
      Hypertrophy                          |             1     1     1        1              2  1     2     1        1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                         1                       1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  M  +  M  +  +  +  M  M  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                      4   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
      Follicular Cell, Hyperplasia         |          3                                      1  2  1        1  2  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                                                     |             
      Inflammation, Suppurative            |    1                                                                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 2| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 7| 5| 6| 4| 5| 5| 5| 5| 5| 5| 3| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6.25 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 4| 5| 1| 2| 3| 4| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         1                                                |             
      Mineralization                       |                         1                                                |             
      Spermatocele                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3              1               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | I  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Hyperplasia                          |                                                          4               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  M  +  +  M  M  M  M  +  +  +  +  +  +  +  +  +  M  +  M|             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Hyperplasia                          |                                                          4               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1  2  1  1                                          |             
      Congestion                           | 3     3                                                              2   |             
      Hematopoietic Cell Proliferation     | 2                    1  2                                                |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |       3     1  1  1           2                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2     1  1           1        2                    2                  |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  I  +  +  +  +  A  +  +  +  +  +  I  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                          1               |             
      Necrosis                             | 2  1                       2              2                          2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  I  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  I  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                            2                                             |             
      Foot, Developmental Malformation     |                            X                                             |             
      Prepuce, Inflammation, Suppurative   |                                           4                              |             
      Subcutaneous Tissue, Angiectasis     |                                                                          |             
      Subcutaneous Tissue, Edema           |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3|             
                                           | 2| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 7| 5| 6| 4| 5| 5| 5| 5| 5| 5| 3| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6.25 PPM                               | 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 4| 5| 1| 2| 3| 4| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    1     1  1  1  1     1     1        1        1        1     1     1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         1                                                |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2              2           1        2        2   |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                       3        2        2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                   2                    3                                 |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1  1        1              1  1        1     1              1  1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1     1  1     1  1     1        1                 1        1        1  1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1              2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Hydronephrosis                       |                                                                   1      |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                         1                                                |             
      Nephropathy                          | 4  1  1     1  1     1  1  1  1  1     1  1  1     1  2  1  1  2     1  1|             
      Papilla, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                           2                              |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    6.25 PPM                               | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                            3                                             |      2  2.0|
      Inflammation                         |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hemorrhage                           |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia           |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Peyer's Patch, Hyperplasia           |                                                             4            |      2  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  1                                       |      4  1.5|
      Basophilic Focus                     |                         X                                            X   |      3     |
      Clear Cell Focus                     |       X                                                                  |      1     |
      Degeneration, Fatty                  |                                                                          |      3  1.0|
      Eosinophilic Focus                   |       X        X                                                         |      6     |
      Inflammation, Chronic                |                                                                   1      |      1  1.0|
      Mixed Cell Focus                     |                            X                                             |      1     |
      Necrosis                             |    1        1                 1                                1         |      5  1.2|
      Centrilobular, Degeneration, Fatty   |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                 +              +                          +   |   5        |
      Fat, Angiectasis                     |                                           1                          2   |      2  1.5|
      Fat, Inflammation, Chronic           |          3                                                               |      1  3.0|
      Fat, Necrosis                        |       2                    2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Angiectasis                  |    2                                                                     |      1  2.0|
      Acinus, Focal Cellular Change        |                                                                          |      1  1.0|
      Acinus, Necrosis                     |             1                                                            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              | 2                       2                                                |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    6.25 PPM                               | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                1                                                         |      1  1.0|
      Pigmentation, Hemosiderin            |                                              1                           |      2  1.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                               +                                +         |   4        |
      Inflammation                         |                               2                                2         |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +                                                            |   1        |
      Inflammation                         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Cardiomyopathy                       |                                  1                                       |      1  1.0|
      Inflammation, Suppurative            |             2                                                            |      1  2.0|
      Necrosis                             |             2                                                            |      1  2.0|
      Endothelium, Hyperplasia             |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                         X|      2     |
      Focal Cellular Change                | 2  1     1     1     2              1  1        1           2            |     13  1.3|
      Hyperplasia                          |                         2     1  4                 2                     |      8  2.0|
      Hypertrophy                          |       1                    2        1  1  1  1     2                     |     16  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    1  1        1  1           1                                          |      8  1.1|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  I  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|  47        |
      Pars Distalis, Cyst                  |                                                                         X|      1     |
      Pars Distalis, Hyperplasia           |                                        2                                 |      1  2.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                X                 X                                       |      3     |
      Follicular Cell, Hyperplasia         |                                              2     2     2  1            |     11  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                            4                                             |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    6.25 PPM                               | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                    3                    1|      2  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                       +                  |   1        |
      Inflammation, Suppurative            |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                       +                  |   2        |
      Inflammation, Suppurative            |                                                       2                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1                                                                     |      1  1.0|
      Inflammation, Suppurative            |                                              1        2                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                2                             2                           |      3  1.7|
      Mineralization                       |                                                                          |      1  1.0|
      Spermatocele                         |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1                    1           1                           |      5  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  M  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|  42        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |    1                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  I  M  +  +  +  M  +  +  +  +  M  M  +  +  M  +  M  +  +  +  +  +  +  +|  39        |
      Hyperplasia                          |          1                 1                             1           2   |      5  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  +  M  M  M  +  M  M  +  +  M  M  M  M  +  +  +  +  +  +  M  M  +  M|  27        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                             2            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Angiectasis                          |          2     1        1                          1              1      |      9  1.2|
      Congestion                           |                         3  3                 4                 3         |      7  3.0|
      Hematopoietic Cell Proliferation     |          3     2        2                          1                     |      7  1.9|
      Hemorrhage                           |                                                                   3      |      1  3.0|
      Hyperplasia                          |    1  2           1        2  2     1  2        2        1  2        4   |     17  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    1  1  1  2           2     1                    1              4     2|     15  1.6|
      Hyperplasia, Lymphoid                |    1                                      1                              |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|  43        |
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    6.25 PPM                               | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |             2                                         3                  |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M|   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Foot, Developmental Malformation     |                                                                          |      1     |
      Prepuce, Inflammation, Suppurative   |                                              4        4                  |      3  4.0|
      Subcutaneous Tissue, Angiectasis     |                                                                         4|      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       | 1  1  1  1     1  1  1        1        1  1  1     1     1              1|     27  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |          1                 1     1     1                                 |      5  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                               2                                          |      6  1.8|
      Inflammation, Chronic, Focal         |                                  2                                       |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                2     2     1  3              2  2                        |      9  2.1|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1                                                        3            |      4  2.3|
      Perivascular, Inflammation, Chronic  |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          1           1        1        1     1     1                     |     15  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                   1      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |    1  1        1        1  1  1  1     1     1     1     1  1        1   |     24  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                         1                                                |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 0| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 7| 5| 5| 1| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    6.25 PPM                               | 5| 5| 6| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 3| 4| 5| 1| 4| 5| 2| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | X     X  X        X           X  X                                   X   |      8     |
      Hydronephrosis                       |                                              2                           |      2  1.5|
      Infarct                              |       1                                                                  |      1  1.0|
      Inflammation, Suppurative            |             2                                                            |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          |       1  1     1           1  1  1  1     1     1  1     1  1  1     1  1|     35  1.1|
      Papilla, Necrosis                    |                                              1        1                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                         +                    +                           |   2        |
      Inflammation, Suppurative            |                                              3                           |      1  3.0|
      Necrosis                             |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dilatation                           |                                              3        3                  |      3  2.7|
      Inflammation                         |                                                       2                  |      1  2.0|
      Necrosis                             |                                              1                           |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|             
                                           | 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  I  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  I  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X                                                            |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |    1                                                                     |             
      Eosinophilic Focus                   |                            X                 X              X            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                         3                                   4            |             
      Inflammation, Focal, Granulomatous   |                                              2                           |             
      Necrosis                             |             1     1              2                                       |             
      Biliary Tract, Cyst                  |                                     X                                    |             
      Centrilobular, Degeneration, Fatty   |             2                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +        +  +           +  +                  |             
      Fat, Angiectasis                     |       2                             1              2                     |             
      Fat, Hemorrhage                      |                            1                                             |             
      Fat, Inflammation, Chronic           |       1                             2              1                     |             
      Fat, Necrosis                        |                                        2              3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                   1  1   |             
      Acinus, Focal Cellular Change        |                            1  1                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                2                                                         |             
      Ulcer                                |                               2                                          |             
      Epithelium, Hyperplasia              |                               3                 1                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2                                                            |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|             
                                           | 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Pigmentation, Hemosiderin            |             1                                                            |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                       +     +                           |             
      Inflammation                         |                2                       3     2                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                     1        1     1           2     1   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Focal Cellular Change                |                1                          1        1                     |             
      Hyperplasia                          |                                                          2               |             
      Hypertrophy                          |    1  1                          2  1                 1     1     1  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Cyst                  |                X           X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                         1                          1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                                                          |             
      Inflammation, Chronic                |                                  1     1                                 |             
                                            __________________________________________________________________________|             
   Penis                                   | +                    M                             +        M            |             
      Hyperplasia                          |                                                    3                     |             
      Inflammation, Suppurative            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +                                                   |             
      Degeneration, Cystic                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                      4                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|             
                                           | 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                      1                                      3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                                                               |             
      Mineralization                       |          1                                                               |             
      Spermatocele                         |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2           2                 1  3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                            4                                             |             
      Hyperplasia                          |                         2                    2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  I  M  +  +  +  +  +  M  +  M  M  M  +  M  M  M  +  +  +  +  M|             
      Hematopoietic Cell Proliferation     |                            3                                             |             
      Hyperplasia                          |                         3                                      2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  I  +  +  +  +  +|             
      Angiectasis                          |          2                                   3     2                     |             
      Congestion                           |                         3                                                |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    2  2                             2     2                          2  2|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                            2     3           1                       2   |             
      Hyperplasia, Histiocytic             |                                     4                                    |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                            2                                             |             
      Necrosis                             | 3           2                    2              2     1     1  2  2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  I  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Inflammation, Suppurative   | 4                    3                                      4            |             
      Subcutaneous Tissue, Angiectasis     |                                                                2     4   |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|             
                                           | 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Pyogranulomatous                |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                      X   |             
      Osteopetrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          1           1     1        1  1        1     1                 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1                                         1           1        2   |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2                                               2        2            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                              2  2                 3  3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1                    1                    1     2  1     1     1  1  1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                            1                                             |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1              1           1     1        1     1        1  1   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       X                  |             
      Hydronephrosis                       |          3                                                               |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                             1        2   |             
      Nephropathy                          |    1  1     1  1           1        1  3              1  1     1        1|             
      Renal Tubule, Mineralization         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 5| 7| 5| 6| 7| 6| 4| 5| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 6| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 4| 3| 1| 0| 3| 8| 5| 8| 3| 1| 3| 3| 1| 3| 3| 3| 5| 8| 8| 8| 3|             
                                           | 7| 4| 4| 2| 0| 4| 7| 4| 4| 0| 6| 5| 4| 8| 4| 4| 0| 4| 4| 4| 8| 6| 9| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    20 PPM                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 1| 3| 4| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
      Inflammation, Suppurative            |                                                             2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 4                    2                                      3            |             
      Inflammation                         | 2                                                                        |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3|            |
                                           | 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    20 PPM                                 | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  +  A  +  +  +  +  +  A  +  +  A  +  +  I  +  +  A  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  +|  44        |
      Epithelium, Hyperplasia              |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  +|  42        |
      Inflammation, Chronic                |                                                    1                     |      1  1.0|
      Pigmentation, Hemosiderin            |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  +|  43        |
      Cyst                                 |          X                                                               |      1     |
      Inflammation, Chronic                |                                                    1                     |      1  1.0|
      Pigmentation, Hemosiderin            |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                         X                                                |      1     |
      Degeneration, Fatty                  |                            1              1                              |      3  1.0|
      Eosinophilic Focus                   |                               X                                          |      4     |
      Hematopoietic Cell Proliferation     |                                                       3                  |      1  3.0|
      Infarct                              | 4              4                                4                        |      5  3.8|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Necrosis                             | 2           1                                2           2        1      |      8  1.5|
      Biliary Tract, Cyst                  |                                                                          |      1     |
      Centrilobular, Degeneration, Fatty   |                                        1                                 |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                               +  +      |   9        |
      Fat, Angiectasis                     |                2                                                         |      4  1.8|
      Fat, Hemorrhage                      |                                                                          |      1  1.0|
      Fat, Inflammation, Chronic           |                2                                                  2      |      5  1.6|
      Fat, Necrosis                        |                2                                               3         |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Acinus, Atrophy                      |                                                                          |      2  1.0|
      Acinus, Focal Cellular Change        |             1                                               1           1|      5  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3|            |
                                           | 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    20 PPM                                 | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                      1   |      2  1.5|
      Epithelium, Hyperplasia              |    2                                                                     |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1                                                                     |      2  1.5|
      Mineralization                       |             2                                                            |      1  2.0|
      Pigmentation, Hemosiderin            |                   2                          2                           |      3  1.7|
      Ulcer                                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                  +     +              +                  |   6        |
      Inflammation                         |                                  3     1              2                  |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                              2                           |      6  1.3|
      Inflammation, Suppurative            |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Focal Cellular Change                |          1              1        1     2                                1|      8  1.1|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |    1                    1  1  1                             1            |     14  1.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Hyperplasia                          |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Hyperplasia                          |                   2     1                    2                           |      4  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |    X                                                     X               |      4     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                         X|      1     |
      Follicular Cell, Hyperplasia         |                1        2                                                |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypospermia                          |                      4                                                   |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3|            |
                                           | 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    20 PPM                                 | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                    3                     |      3  1.7|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                     +                    M  M  +         |   4        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                     3                          2         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +           +                                +   |   4        |
      Degeneration, Cystic                 |                                                                      2   |      1  2.0|
      Inflammation, Suppurative            |                                     2                                    |      1  2.0|
      Duct, Dilatation                     |                         3                                                |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                            1                                             |      2  1.5|
      Inflammation, Suppurative            |                   3                                      1  2            |      5  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      3                             1              2      |      4  1.8|
      Mineralization                       |                                                    1                     |      2  1.0|
      Spermatocele                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       3  2  2            |      7  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Iliac, Hyperplasia                   |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  +  +  M|  42        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia                          |    2  2                                                                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  M  +  M|  38        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  M  +  +  M  M  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +|  33        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia                          |    2                 2                                                   |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                     1                                   1|      5  1.8|
      Congestion                           |             4                 3     4                                    |      4  3.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                      3   |      1  3.0|
      Hyperplasia                          |       2  2     2                 1     2                                1|     12  1.8|
      Inflammation                         |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3|            |
                                           | 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    20 PPM                                 | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                        1        2     3           1  2   |      9  1.9|
      Hyperplasia, Histiocytic             |                                                                          |      1  4.0|
      Necrosis                             |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  42        |
      Hyperplasia, Lymphoid                |                                                                         1|      1  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Necrosis                             |    2  2           2  2     1        1        2              2     1  1   |     18  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  I  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Prepuce, Inflammation, Suppurative   |                                     3                    3  3  3         |      7  3.3|
      Subcutaneous Tissue, Angiectasis     |                                                                          |      2  3.0|
      Subcutaneous Tissue, Edema           |                                              2                           |      1  2.0|
      Subcutaneous Tissue, Hemorrhage      |                                              3                           |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Pyogranulomatous                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fracture                             |                                                                          |      1     |
      Osteopetrosis                        |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             M                                                            |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |          1              1        1     1        1  1              1     1|     16  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |          1        2                                                      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              2                    1      |      6  1.3|
      Inflammation, Chronic, Diffuse       |    3                                                                     |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                2  2                                                  2   |      6  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    3     2                                                     2         |      7  2.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          1     1     1  1  1  1  1  1  1  1        1  1                  |     21  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 2| 7| 5| 7| 5| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 5| 5| 7| 6| 7|            |
                             DAY ON TEST   | 5| 3| 8| 3| 7| 3| 8| 6| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 9| 3|            |
                                           | 1| 4| 9| 4| 3| 4| 6| 8| 4| 2| 4| 4| 7| 4| 4| 9| 4| 4| 4| 1| 2| 6| 4| 3| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|      A     |
    20 PPM                                 | 3| 3| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0|      L     |
                                           | 4| 5| 1| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 5| 1| 2| 4| 5| 1| 2| 4| 1| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1     1  1  1     1  1     1                    1              1  1  1|     19  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1                    2     2                          3               |      4  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infarct                              |                   2                                                      |      1  2.0|
      Inflammation, Suppurative            |                   2                                         1            |      4  1.5|
      Nephropathy                          | 2        1  4           1        1     1  1     2  1              1     1|     22  1.3|
      Renal Tubule, Mineralization         |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                   3                 3                    3  3  3         |      8  3.0|
      Inflammation                         |                   3                                            2         |      3  2.3|
      Transitional Epithelium, Hyperplasia |                   1                                                      |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|             
                                           | 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
    62.5 PPM                               | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|             
                                           | 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  A  M  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  I  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hemorrhage                           |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Peyer's Patch, Hyperplasia           |                         3                       2                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Angiectasis                          |                   1           4                                          |             
      Basophilic Focus                     |                                                                          |             
      Developmental Malformation           |                                              X                           |             
      Eosinophilic Focus                   |                         X                                                |             
      Hematopoietic Cell Proliferation     |             2                                         2                  |             
      Infarct                              |                                  4                                      4|             
      Mixed Cell Focus                     |                                        X                 X               |             
      Necrosis                             |       2     2                 1  1  2              1     3        1      |             
      Centrilobular, Necrosis              |                      3     3                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +     +  +                    +                              |             
      Fat, Angiectasis                     |          2        2                       2                              |             
      Fat, Hemorrhage                      |             2        2                                                   |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Acinus, Focal Cellular Change        | 1                             1                                         1|             
      Acinus, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                        +                                 |             
      Epithelium, Hyperplasia              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Pigmentation, Hemosiderin            |             2        2     1                                             |             
      Ulcer                                |             2        2     1                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +           +  +            |             
      Developmental Malformation           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|             
                                           | 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
    62.5 PPM                               | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|             
                                           | 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                              1           2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Cardiomyopathy                       |       1                                                                  |             
      Mineralization                       |                      1                                                   |             
      Endothelium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Focal Cellular Change                | 1                             2           1     1                 2      |             
      Hyperplasia                          |                                           1                              |             
      Hypertrophy                          | 1  2     1                 1                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                                                             2           1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia           |                         1                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Cyst                                 |                                                 X                        |             
      C-Cell, Hyperplasia                  | 2                                                                        |             
      Follicular Cell, Hyperplasia         | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Degeneration                         |             2              1                                             |             
      Inflammation, Chronic                |                            3           2                                 |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                         +                          +|             
      Inflammation, Suppurative            |                                                                         2|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                                +  +                       +|             
      Degeneration, Cystic                 |             4                                   2                        |             
      Inflammation, Suppurative            |                                                 3                        |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                         2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|             
                                           | 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
    62.5 PPM                               | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|             
                                           | 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Atrophy                              |                                        1                                 |             
      Degeneration                         |             1        2     1                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Angiectasis                          |                                                                   2      |             
      Hyperplasia                          |    2                             2           2     2  3        2  2     2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                                                                          |             
      Iliac, Hyperplasia                   |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  M  +  +  M  +  M  I  +  +  +  +  +  +  +  +  M  M  +  A  +|             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  M  M  M  +  M  +  M  A  M|             
      Hyperplasia                          |                         2                                2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  M  M  M  +  M  +  +  +  +  +  M  +  +  M  M  M  +  +  M  A  M|             
      Congestion                           |                                                 3                        |             
      Hematopoietic Cell Proliferation     |                                                 1                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +|             
      Angiectasis                          |                   2                       1              1               |             
      Congestion                           |                         2        3        2     3                 1      |             
      Hematopoietic Cell Proliferation     |                                                          2        2      |             
      Hyperplasia                          | 1  3                                            2                        |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hematopoietic Cell Proliferation     |       4     3     1     1     2                 1     3  2        2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Necrosis                             |       2              2     2     1  1  2           2                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic                |                                              3                           |             
      Hair Follicle, Atrophy               |                                                                          |             
      Prepuce, Inflammation, Suppurative   |    2                                                                    4|             
      Subcutaneous Tissue, Angiectasis     | 1                                                                        |             
      Subcutaneous Tissue, Edema           |             2                                                            |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|             
                                           | 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
    62.5 PPM                               | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|             
                                           | 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hemorrhage                           |                                     1                                    |             
      Mineralization                       | 1  1              1        1     1           1  1        1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |                                                    1                    1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4                             3                                    |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         2     1                    2     1     1  2     2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       3                                                  2     2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |                      1  1           1                    2  1     1     1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                    1     2               |             
      Olfactory Epithelium, Atrophy        |                                                             2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            | 1  1     1              1  1           1  1              1  1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          +                                                               |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Lens, Degeneration                   |                         1                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          | 1                    1                          4  4                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |    1                                                                     |             
      Inflammation, Suppurative            |                                                                         1|             
      Nephropathy                          | 1        1        1     1     1           1  1              1     1      |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Renal Tubule, Hyperplasia            |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 4| 7| 5| 7| 6| 7| 5| 6| 5| 7| 6| 7| 7| 3| 7| 4| 5| 7| 2| 5|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 7| 3| 9| 3| 4| 0| 2| 3| 9| 3| 1| 5| 3| 6| 4| 3| 0| 9|             
                                           | 3| 3| 8| 3| 5| 1| 3| 4| 3| 6| 3| 6| 7| 5| 3| 5| 3| 3| 2| 3| 4| 6| 3| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|             
    62.5 PPM                               | 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1|             
                                           | 2| 3| 4| 5| 2| 3| 4| 1| 2| 3| 4| 2| 5| 1| 2| 3| 4| 5| 1| 2| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                                         +                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Dilatation                           |    3                                         2                          3|             
      Inflammation                         |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0|            |
                                           | 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    62.5 PPM                               | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  I  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  A  M  I  +  +  +  +  +  +  +  +  +     A  M  A  +  +  +  +|  36        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +|  44        |
      Peyer's Patch, Hyperplasia           |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     I  +  +  +  +  +  +|  46        |
      Peyer's Patch, Hyperplasia           |                         4              2                                 |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     A  +  A  +  +  +  +|  44        |
      Peyer's Patch, Hyperplasia           |                                                 4                        |      3  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Angiectasis                          |       2                                                                  |      3  2.3|
      Basophilic Focus                     |    X                                         X                 X     X  X|      5     |
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |                            X                                            X|      3     |
      Hematopoietic Cell Proliferation     |                                                                4         |      3  2.7|
      Infarct                              |                                                                   4      |      3  4.0|
      Mixed Cell Focus                     |                      X                 X                                 |      4     |
      Necrosis                             |                         2  1     3                    2     1            |     13  1.7|
      Centrilobular, Necrosis              |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +           +        +              +                       +  +  +  +  +|  14        |
      Fat, Angiectasis                     | 2                    1                                      2            |      6  1.8|
      Fat, Hemorrhage                      |             1                                                            |      3  1.7|
      Fat, Inflammation, Chronic           | 1                                                              2         |      2  1.5|
      Fat, Necrosis                        |                                                             2  3         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Acinus, Focal Cellular Change        |                                                          1               |      4  1.0|
      Acinus, Inflammation, Chronic        |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Ulcer                                |                               3              2  2           2            |      4  2.3|
      Epithelium, Hyperplasia              | 2                             2     2           2           2            |      6  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0|            |
                                           | 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    62.5 PPM                               | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Pigmentation, Hemosiderin            |                         2        1                                       |      5  1.6|
      Ulcer                                |                         2        1                                       |      5  1.6|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Developmental Malformation           |                                                                          |      1     |
      Inflammation                         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Cardiomyopathy                       |                                           1                             2|      3  1.3|
      Mineralization                       |                                                                          |      1  1.0|
      Endothelium, Hyperplasia             |                               2                                3         |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +|  47        |
      Focal Cellular Change                |                   1  1                          1        1        1  1  1|     12  1.2|
      Hyperplasia                          |                               2     3                                    |      3  2.0|
      Hypertrophy                          |             1                 2        1  1     1        1     1         |     11  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +|  44        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                              2                           |      3  1.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  M  M  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                      X                                                   |      2     |
      Pars Distalis, Hyperplasia           | 1                                                                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Cyst                                 |       X              X                 X                                 |      4     |
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                           4                    4  2     1|      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Degeneration                         |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0|            |
                                           | 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    62.5 PPM                               | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |          +     +                    +  +                                 |   7        |
      Inflammation, Suppurative            |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +           +  +                                      +        +|   9        |
      Degeneration, Cystic                 |                         2                                                |      3  2.7|
      Inflammation, Suppurative            |                                                                         2|      2  2.5|
      Duct, Dilatation                     |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  I  M  +|  45        |
      Hyperplasia                          |    1                                                                     |      1  1.0|
      Inflammation, Suppurative            |                                                                         2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                      1   |      2  1.0|
      Degeneration                         |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |       2  2           2        2     2                    2     2  2     2|     17  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                3         |      1  3.0|
      Iliac, Hyperplasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +     +  +  +  +  +  +  M|  37        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +     +  M  +  +  +  +  +|  33        |
      Hyperplasia                          |                      2  2                                                |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +|  32        |
      Congestion                           |                                                             3            |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
      Angiectasis                          |                         2     1           1                 3     2      |      8  1.6|
      Congestion                           |                   2        2                 2  3                       2|     10  2.2|
      Hematopoietic Cell Proliferation     |                                                 2                       2|      4  2.0|
      Hyperplasia                          |                   2     2                       3                 2      |      7  2.1|
      Inflammation, Granulomatous          |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |          2        2  2  2           2     2  2  1        2  2  4     1  2|     22  2.0|
      Hyperplasia, Lymphoid                |                                        3        2                        |      2  2.5|
      Necrosis                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0|            |
                                           | 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    62.5 PPM                               | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  A  +  +  I  +  +  +  +  +  M  M  +     +  +  +  +  +  +  +|  40        |
      Hyperplasia, Lymphoid                |                                                 4                        |      2  3.5|
      Necrosis                             |       3  2  2              2  1     1  1                 1  2  1         |     17  1.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Cyst Epithelial Inclusion            |       X                                                                  |      1     |
      Inflammation, Chronic                |                      2                                         2         |      3  2.3|
      Hair Follicle, Atrophy               |                                                                      1   |      1  1.0|
      Prepuce, Inflammation, Suppurative   |          4     4                    4                          3        4|      7  3.6|
      Subcutaneous Tissue, Angiectasis     |                                                                          |      1  1.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Mineralization                       |       1  1  1                                1        1        1        1|     15  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
      Inflammation, Suppurative            |                                  2  1                                    |      4  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |          1                                                               |      3  2.7|
      Inflammation, Chronic, Focal         |                                                                3         |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |       2           1  4                    1     2                       2|     13  1.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                              3              3            |      5  2.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |                         1     1     1     1     1                 1  1  1|     15  1.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 6| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 0| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 9| 5| 4| 3| 3| 3| 6| 4| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 0| 3| 3| 3| 0|            |
                                           | 3| 6| 6| 8| 9| 7| 3| 3| 2| 0| 3| 4| 3| 3| 3| 0| 3| 2| 4| 3| 7| 3| 3| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    62.5 PPM                               | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 4| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 2| 3| 4| 5| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Suppurative                     |                      2  2     2  2        1  1              1            |      9  1.6|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
      Inflammation, Suppurative            | 1        1                    1        1                    1     1  1  1|     19  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   2        |
      Lens, Degeneration                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                   2  2   |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Cyst                                 | X                    X                                                   |      2     |
      Hydronephrosis                       |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Nephropathy                          | 1        1        1  2  1           1     2  1  1                       1|     19  1.1|
      Capsule, Inflammation, Chronic       |                            2                                             |      1  2.0|
      Renal Tubule, Hyperplasia            | 1                                            1                           |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |          +                          +  +                       +         |   6        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Dilatation                           |          3     2                       2                       3        2|      8  2.5|
      Inflammation                         |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 5| 5| 4| 6| 6| 1| 2| 5| 6| 5| 6| 6| 7| 6| 5| 6| 6| 5| 5| 4| 5| 2|             
                             DAY ON TEST   | 7| 8| 6| 9| 9| 9| 7| 4| 7| 1| 9| 6| 3| 9| 2| 3| 2| 9| 2| 1| 6| 6| 7| 6| 8|             
                                           | 4| 2| 8| 6| 6| 5| 3| 9| 1| 7| 6| 0| 7| 7| 9| 3| 4| 8| 0| 0| 8| 9| 4| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 0|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 4| 5| 2| 4| 5| 2| 3| 4| 5| 1| 3| 5| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  A  M  +  A  A  A  +  +  +  +  A  A  +  A  +  +  A|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  A  A  +  +  +  A  A  A  +  +  +  +  A|             
      Angiectasis                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  A  M  A  +  +  +  +  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  A  A  +  +  +  A  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  A  +  +  A  A  +  +  +  A  A  A  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Basophilic Focus                     | X                                                                        |             
      Degeneration, Fatty                  |                                                                   2      |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |             X                                                            |             
      Hematopoietic Cell Proliferation     |                      2                                                   |             
      Inflammation, Focal, Granulomatous   |                                                                   2      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |    1              2              2  2        2  3        3               |             
      Biliary Tract, Hyperplasia           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +  +           +                 +                     |             
      Fat, Angiectasis                     |                   3              2                                       |             
      Fat, Hemorrhage                      |                                                    2                     |             
      Fat, Inflammation, Chronic           |                      2           2                 3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      Acinus, Atrophy                      |                                                 3                        |             
      Acinus, Focal Cellular Change        |                                                                1         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                        +                                 |             
      Epithelium, Hyperplasia              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Ulcer                                |                      2  1                                         1      |             
      Epithelium, Hyperplasia              | 1                       3                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      Pigmentation, Hemosiderin            |    2              2  2     1           2                 2               |             
      Ulcer                                |                   2  2     2                                      2      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Inflammation                         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 5| 5| 4| 6| 6| 1| 2| 5| 6| 5| 6| 6| 7| 6| 5| 6| 6| 5| 5| 4| 5| 2|             
                             DAY ON TEST   | 7| 8| 6| 9| 9| 9| 7| 4| 7| 1| 9| 6| 3| 9| 2| 3| 2| 9| 2| 1| 6| 6| 7| 6| 8|             
                                           | 4| 2| 8| 6| 6| 5| 3| 9| 1| 7| 6| 0| 7| 7| 9| 3| 4| 8| 0| 0| 8| 9| 4| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 0|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 4| 5| 2| 4| 5| 2| 3| 4| 5| 1| 3| 5| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Cardiomyopathy                       |             1                                1                           |             
      Mineralization                       |                   1  1                                   1               |             
      Endothelium, Hyperplasia             |                                           2     1  1                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                1                  |             
      Hypertrophy                          | 1                                         1                 2        1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  M  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cyst                                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                2                                                         |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +                 +  +           +                           |             
      Degeneration, Cystic                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |          2                 2              1     1                        |             
      Degeneration                         |                      2                                                   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 5| 5| 4| 6| 6| 1| 2| 5| 6| 5| 6| 6| 7| 6| 5| 6| 6| 5| 5| 4| 5| 2|             
                             DAY ON TEST   | 7| 8| 6| 9| 9| 9| 7| 4| 7| 1| 9| 6| 3| 9| 2| 3| 2| 9| 2| 1| 6| 6| 7| 6| 8|             
                                           | 4| 2| 8| 6| 6| 5| 3| 9| 1| 7| 6| 0| 7| 7| 9| 3| 4| 8| 0| 0| 8| 9| 4| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 0|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 4| 5| 2| 4| 5| 2| 3| 4| 5| 1| 3| 5| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2        3  2        2     2  2           2           3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  M  +  M  +  M  +  +  +  +  M  M  +  +  +  +  +|             
      Hyperplasia                          |                2                                                     2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Hyperplasia                          |                2                       2  3                 3        2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +|             
      Hyperplasia                          |                      2                          2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Angiectasis                          |             3        3        4                    4                     |             
      Congestion                           |       3                                                        2     2   |             
      Hematopoietic Cell Proliferation     |          1                    2                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |       2  3  2        2     1  1  2     2     2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  +  +  M  +  M  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +|             
      Necrosis                             |       2  2        2              2     2  2        2           2        3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |       3                                                                  |             
      Hair Follicle, Atrophy               |       3                                                                  |             
      Prepuce, Inflammation, Suppurative   |                               3                                          |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
      Subcutaneous Tissue, Angiectasis     | 3                                            4                           |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Pyogranulomatous                |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
      Cranium, Hemorrhage                  |                                     3                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    1                                                                    1|             
      Mineralization                       |                                     2  1                             1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 5| 5| 5| 4| 6| 6| 1| 2| 5| 6| 5| 6| 6| 7| 6| 5| 6| 6| 5| 5| 4| 5| 2|             
                             DAY ON TEST   | 7| 8| 6| 9| 9| 9| 7| 4| 7| 1| 9| 6| 3| 9| 2| 3| 2| 9| 2| 1| 6| 6| 7| 6| 8|             
                                           | 4| 2| 8| 6| 6| 5| 3| 9| 1| 7| 6| 0| 7| 7| 9| 3| 4| 8| 0| 0| 8| 9| 4| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    200 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 9| 9| 0|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 4| 5| 2| 4| 5| 2| 3| 4| 5| 1| 3| 5| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  A|             
      Inflammation, Suppurative            | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   4                                      1              3|             
      Inflammation, Suppurative            |                            2                                             |             
      Alveolar Epithelium, Hyperplasia     |       2                       2  3                 1        2        1  2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2     2           2                    2  3  2  2                 3      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        1           1  1              1   |             
      Inflammation, Pyogranulomatous       |                            3                                             |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 2                    2        1        1                    1            |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  A|             
      Inflammation, Suppurative            | 1              1                       1        1              1     1   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                       +     +      |             
      Degeneration                         |                                     3                                    |             
      Cornea, Hyperplasia                  |                                                                   3      |             
      Cornea, Inflammation, Chronic        |                                                             3     3      |             
      Lens, Degeneration                   |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |       2                       3     1     1  3                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                2                                                         |             
      Inflammation, Suppurative            |                            3                                             |             
      Nephropathy                          |       1                             1     1  1  2  1                     |             
      Renal Tubule, Hyperplasia            |                      1                                                   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Dilatation                           |          3  3                 3     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 4| 5| 4| 7| 5| 5| 6| 3| 5| 6| 5| 6| 5| 5| 4| 5| 7| 6| 4| 6| 3| 5| 5|            |
                             DAY ON TEST   | 5| 3| 7| 9| 7| 3| 7| 8| 3| 7| 9| 2| 6| 5| 3| 8| 9| 1| 3| 2| 8| 9| 5| 6| 2|            |
                                           | 1| 3| 0| 5| 4| 3| 3| 2| 9| 1| 6| 3| 8| 2| 0| 3| 5| 9| 3| 4| 1| 2| 1| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    200 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 5| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  A  A  +  +  A  +  +  A  +  A  +  A  +  +  +  M  +  M|  32        |
      Hyperplasia                          |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|  40        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  A|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  A  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  A|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  A  +  A|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  A  A  +  +  +  +  +  A  +  A  +  A  +  A  +  A  +  A|  33        |
      Peyer's Patch, Hyperplasia           |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Basophilic Focus                     |                                                                          |      1     |
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Developmental Malformation           |                                                       X                  |      1     |
      Eosinophilic Focus                   |    X                             X        X                              |      4     |
      Hematopoietic Cell Proliferation     |                1                 2  1                                    |      4  1.5|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                        X                                 |      1     |
      Necrosis                             |          3  3     3                          2     2     2              3|     14  2.4|
      Biliary Tract, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +              +                                      +           +   |   9        |
      Fat, Angiectasis                     |    2                                                                     |      3  2.3|
      Fat, Hemorrhage                      |                                                                          |      1  2.0|
      Fat, Inflammation, Chronic           |    2                                                                 2   |      5  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Acinus, Atrophy                      |                                                                          |      1  3.0|
      Acinus, Focal Cellular Change        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ulcer                                |          1                                                               |      4  1.3|
      Epithelium, Hyperplasia              |          2              2                                                |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 107                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 4| 5| 4| 7| 5| 5| 6| 3| 5| 6| 5| 6| 5| 5| 4| 5| 7| 6| 4| 6| 3| 5| 5|            |
                             DAY ON TEST   | 5| 3| 7| 9| 7| 3| 7| 8| 3| 7| 9| 2| 6| 5| 3| 8| 9| 1| 3| 2| 8| 9| 5| 6| 2|            |
                                           | 1| 3| 0| 5| 4| 3| 3| 2| 9| 1| 6| 3| 8| 2| 0| 3| 5| 9| 3| 4| 1| 2| 1| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    200 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 5| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |             2     1        2                                             |      9  1.8|
      Ulcer                                |          1  2     1        1                                             |      8  1.6|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cardiomyopathy                       |                                                                          |      2  1.0|
      Mineralization                       |                                                                          |      3  1.0|
      Endothelium, Hyperplasia             |                                                 1                        |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Hyperplasia                          |                      2  2                                                |      4  1.8|
      Hypertrophy                          |                      1                                                  1|      6  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|  44        |
      Hyperplasia                          |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Hyperplasia                          |          1  2                 1                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  A  +  +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +  +  M  M  +  M|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Cyst                  |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Cyst                                 |                                           X                              |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                +         |   1        |
      Inflammation, Suppurative            |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                +         |   6        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Hyperplasia                          |                                        4                                 |      1  4.0|
      Inflammation, Suppurative            |                                                                2         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 108                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 4| 5| 4| 7| 5| 5| 6| 3| 5| 6| 5| 6| 5| 5| 4| 5| 7| 6| 4| 6| 3| 5| 5|            |
                             DAY ON TEST   | 5| 3| 7| 9| 7| 3| 7| 8| 3| 7| 9| 2| 6| 5| 3| 8| 9| 1| 3| 2| 8| 9| 5| 6| 2|            |
                                           | 1| 3| 0| 5| 4| 3| 3| 2| 9| 1| 6| 3| 8| 2| 0| 3| 5| 9| 3| 4| 1| 2| 1| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    200 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 5| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|  44        |
      Inflammation, Suppurative            |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                      2   |      1  2.0|
      Atrophy                              |                                                          1           1   |      6  1.3|
      Degeneration                         |                                                                          |      1  2.0|
      Hemorrhage                           |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                2              2        2                       3         |     12  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  M  +  +|  37        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  M  M  +  +  +  +  +  M  I  +  +  M  +  +  +  +  +  +  +  +  +|  39        |
      Hyperplasia                          |                      2        2                                      2   |      8  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  A  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  40        |
      Hyperplasia                          |                                        2                                 |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Angiectasis                          |    2                          2           2                              |      7  2.9|
      Congestion                           |                3     4           3                                       |      6  2.8|
      Hematopoietic Cell Proliferation     |                3                 2        2                              |      5  2.0|
      Hyperplasia                          |                                              2                       2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Depletion Lymphoid                   |                            2                                             |      1  2.0|
      Hematopoietic Cell Proliferation     |    2           2              2  2  2  1  2  2     2  2                 2|     20  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  A  +  +  M  +  +  M  M  +  +  +  M  +  +  M  +  M  M  +  M  +  +  +|  35        |
      Necrosis                             |             2     2  2        1  2  2     2        1                 1  2|     19  1.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                      2   |      1  2.0|
      Inflammation, Chronic                |          2                    4                                          |      3  3.0|
      Hair Follicle, Atrophy               |                                                                          |      1  3.0|
      Prepuce, Inflammation, Suppurative   |                                                                4         |      2  3.5|
      Sebaceous Gland, Hyperplasia         |                                                                      2   |      1  2.0|
      Subcutaneous Tissue, Angiectasis     |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 109                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 4| 5| 4| 7| 5| 5| 6| 3| 5| 6| 5| 6| 5| 5| 4| 5| 7| 6| 4| 6| 3| 5| 5|            |
                             DAY ON TEST   | 5| 3| 7| 9| 7| 3| 7| 8| 3| 7| 9| 2| 6| 5| 3| 8| 9| 1| 3| 2| 8| 9| 5| 6| 2|            |
                                           | 1| 3| 0| 5| 4| 3| 3| 2| 9| 1| 6| 3| 8| 2| 0| 3| 5| 9| 3| 4| 1| 2| 1| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    200 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 5| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Pyogranulomatous                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                  1                                       |      1  1.0|
      Cranium, Hemorrhage                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                        +                                 |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  1.0|
      Mineralization                       |    1  1        1                                               2        1|      9  1.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  M  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  43        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                   1                                                      |      4  2.3|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    3        2  2  1  1                    4  2     2  2              2   |     17  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    2           2                       3                       2         |     12  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |    1           1     1                    1                              |      8  1.0|
      Inflammation, Pyogranulomatous       |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1        1              2                                               2|      9  1.4|
      Olfactory Epithelium, Atrophy        |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
      Inflammation, Suppurative            |    1           1                       1                    1  1     1   |     12  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +     +           +        +                                          |   8        |
      Degeneration                         |                                                                          |      1  3.0|
      Cornea, Hyperplasia                  |    1                          3                                          |      3  2.3|
      Cornea, Inflammation, Chronic        |    2     1           4        3                                          |      6  2.7|
      Lens, Degeneration                   |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 110                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 4| 5| 4| 7| 5| 5| 6| 3| 5| 6| 5| 6| 5| 5| 4| 5| 7| 6| 4| 6| 3| 5| 5|            |
                             DAY ON TEST   | 5| 3| 7| 9| 7| 3| 7| 8| 3| 7| 9| 2| 6| 5| 3| 8| 9| 1| 3| 2| 8| 9| 5| 6| 2|            |
                                           | 1| 3| 0| 5| 4| 3| 3| 2| 9| 1| 6| 3| 8| 2| 0| 3| 5| 9| 3| 4| 1| 2| 1| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    200 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6|      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 5| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                  2        2                             2|      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Cyst                                 |                                                          X               |      1     |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |       2                                                        1         |      3  2.0|
      Nephropathy                          |    1           1                       1           1                 1   |     11  1.1|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                       +        +         |   2        |
      Inflammation, Suppurative            |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Dilatation                           |                                                                3         |      5  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 111                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 3| 3| 2| 1| 3| 2| 2| 3| 1|             
                             DAY ON TEST   | 8| 9| 5| 1| 7| 9| 3| 3| 8| 8| 9| 4| 4| 5| 6| 8| 2| 5| 3| 6| 1| 2| 2| 7| 6|             
                                           | 4| 5| 2| 2| 4| 7| 6| 9| 6| 8| 1| 3| 3| 1| 8| 0| 7| 2| 2| 1| 0| 8| 7| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    625 PPM                                | 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
                                           | 1| 2| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  A  I  A  +  A  +  A  +  +  +  +  A  A  +  +  +  +  A  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +|             
      Anus, Inflammation, Suppurative      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +|             
      Necrosis                             |    4                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  I  +  +  A  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  A  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  A  A  A  +  I  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |       1                                            1        1            |             
      Hyperplasia, Focal                   |                                                                          |             
      Mineralization                       |                      1                                                  2|             
      Necrosis                             |    1                 2                       2  2  1  1        1     2  2|             
      Centrilobular, Degeneration, Fatty   |       1     3                                                            |             
      Centrilobular, Necrosis              | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +                                                     +   |             
      Fat, Hemorrhage                      |                2                                                         |             
      Fat, Necrosis                        |    3                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Acinus, Focal Cellular Change        |    2                                                                     |             
      Acinus, Inflammation, Chronic        |    1                                                                     |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                 +                        |             
      Palate, Inflammation, Chronic        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                                                               |             
      Ulcer                                |    1                                   1     1     1           1         |             
      Epithelium, Hyperplasia              |       1  2  2  4        3  2  2        3     3  2  2  2     2  2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  M  A  A  +  +|             
      Mineralization                       |                                                                          |             
      Pigmentation, Hemosiderin            |                                              2                           |             
      Ulcer                                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
      Mineralization                       |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 112                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 3| 3| 2| 1| 3| 2| 2| 3| 1|             
                             DAY ON TEST   | 8| 9| 5| 1| 7| 9| 3| 3| 8| 8| 9| 4| 4| 5| 6| 8| 2| 5| 3| 6| 1| 2| 2| 7| 6|             
                                           | 4| 5| 2| 2| 4| 7| 6| 9| 6| 8| 1| 3| 3| 1| 8| 0| 7| 2| 2| 1| 0| 8| 7| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    625 PPM                                | 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
                                           | 1| 2| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2                                                                     |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       | 2              1  2  1        1     2        2  1                        |             
      Necrosis                             |                                                                          |             
      Atrium, Thrombosis                   | 2                                                                        |             
      Endothelium, Hyperplasia             |                                                    1        2            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  A  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  M  +  +  M  +  +  M  +  +  M  +  +  +  +  M|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  +  +  +  +  +  I  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |    +                                                                     |             
      Inflammation, Suppurative            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                +         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  A  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                 1                        |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2     1     2  2  2        1  2  2  1           1  2  2  2  1  2     1  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | M                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3  1     2  2  3  3                       3  4  2  2  3     2        2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 113                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 3| 3| 2| 1| 3| 2| 2| 3| 1|             
                             DAY ON TEST   | 8| 9| 5| 1| 7| 9| 3| 3| 8| 8| 9| 4| 4| 5| 6| 8| 2| 5| 3| 6| 1| 2| 2| 7| 6|             
                                           | 4| 5| 2| 2| 4| 7| 6| 9| 6| 8| 1| 3| 3| 1| 8| 0| 7| 2| 2| 1| 0| 8| 7| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    625 PPM                                | 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
                                           | 1| 2| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Megakaryocyte |                                                    2                     |             
      Necrosis                             |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Renal, Mineralization                |                                                       1                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  +  M  M  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  M  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Histiocytic             | 4                                                                        |             
      Hyperplasia, Plasma Cell             |                                                    3                     |             
      Mineralization                       |                      3              2                                    |             
      Necrosis                             |                      3              2        2  2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             | 4                                                                        |             
      Inflammation                         |    3                                                                     |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +|             
      Depletion Lymphoid                   |    3                                                                     |             
      Hematopoietic Cell Proliferation     |    2                 3                       1  2  2  2              2   |             
      Hyperplasia, Histiocytic             | 2                    3                                                   |             
      Mineralization                       |                      2                                                   |             
      Necrosis                             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
      Necrosis                             | 3  2              2                                                  2  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Hair Follicle, Inflammation,         |                                                                          |             
          Suppurative                      |                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 114                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 3| 3| 2| 1| 3| 2| 2| 3| 1|             
                             DAY ON TEST   | 8| 9| 5| 1| 7| 9| 3| 3| 8| 8| 9| 4| 4| 5| 6| 8| 2| 5| 3| 6| 1| 2| 2| 7| 6|             
                                           | 4| 5| 2| 2| 4| 7| 6| 9| 6| 8| 1| 3| 3| 1| 8| 0| 7| 2| 2| 1| 0| 8| 7| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    625 PPM                                | 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
                                           | 1| 2| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             1                                         1  1     1         |             
      Mineralization                       |                                                             1        1   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +  +              +               |             
      Hemorrhage                           |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                2         |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 2  1  1     4            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Alveolus, Pigmentation, Hemosiderin  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Suppurative            |                               2                                          |             
      Olfactory Epithelium, Atrophy        |             1                 3                                          |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |             1                 1                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                    +            |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  I  M  +  M  M  M  +  +  +  M  +  +  +  M  +  +  M  +  M|             
      Hyperplasia                          |             2                          4        3           1            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |    2                                                                     |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Hyperplasia                  |                      2                                1                  |             
      Pelvis, Mineralization               |                      1                                1                  |             
      Renal Tubule, Hyperplasia            |                                              3                           |             
      Renal Tubule, Mineralization         |    2                             1                    1                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 115                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 3| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 3| 3| 2| 1| 3| 2| 2| 3| 1|             
                             DAY ON TEST   | 8| 9| 5| 1| 7| 9| 3| 3| 8| 8| 9| 4| 4| 5| 6| 8| 2| 5| 3| 6| 1| 2| 2| 7| 6|             
                                           | 4| 5| 2| 2| 4| 7| 6| 9| 6| 8| 1| 3| 3| 1| 8| 0| 7| 2| 2| 1| 0| 8| 7| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    625 PPM                                | 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
                                           | 1| 2| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                          2               |             
      Inflammation                         |    2                                            1                       2|             
      Transitional Epithelium, Hyperplasia |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 116                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 4| 1| 2| 2| 2| 2| 1| 3| 2| 1| 2| 4| 3| 2| 2| 2| 4| 2| 2| 3| 2|             
                             DAY ON TEST   | 1| 5| 2| 3| 1| 8| 7| 7| 2| 5| 6| 0| 1| 8| 9| 1| 1| 4| 5| 4| 2| 4| 5| 0| 8|             
                                           | 6| 8| 2| 8| 4| 2| 3| 7| 3| 7| 7| 6| 8| 0| 7| 2| 9| 3| 0| 9| 2| 3| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    625 PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 1| 3| 4| 1| 2| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 2| 3| 4| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  A  A  +  +  A  +  +  A  +  +  +  A  +  M  +  +  +  M  A  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Anus, Inflammation, Suppurative      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  A  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  I  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  A  +  +  I  +  +  +  M  +  +  +  +  +  A  +  +  +  A  A  A|             
      Hemorrhage                           |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  I  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  A  +  A  +  A  A  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  1                                1      |             
      Hyperplasia, Focal                   |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |    3        2                             2              2  2            |             
      Centrilobular, Degeneration, Fatty   |                                                       2                  |             
      Centrilobular, Necrosis              |                            1                          1                 3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Focal Cellular Change        |                                                                          |             
      Acinus, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Ulcer                                |             2  1                    2                                    |             
      Epithelium, Hyperplasia              |       1  2  2  2  1     2  3     1  2     3     1     1     4  2  1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               1                                          |             
      Pigmentation, Hemosiderin            |    1                 1                                                  1|             
      Ulcer                                | 4     2     1                                1                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 117                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 4| 1| 2| 2| 2| 2| 1| 3| 2| 1| 2| 4| 3| 2| 2| 2| 4| 2| 2| 3| 2|             
                             DAY ON TEST   | 1| 5| 2| 3| 1| 8| 7| 7| 2| 5| 6| 0| 1| 8| 9| 1| 1| 4| 5| 4| 2| 4| 5| 0| 8|             
                                           | 6| 8| 2| 8| 4| 2| 3| 7| 3| 7| 7| 6| 8| 0| 7| 2| 9| 3| 0| 9| 2| 3| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    625 PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 1| 3| 4| 1| 2| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 2| 3| 4| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1                                                                     |             
      Hemorrhage                           | 1                                                                        |             
      Mineralization                       |    2              2              2           2                           |             
      Necrosis                             |                                                                          |             
      Atrium, Thrombosis                   |                            2                                             |             
      Endothelium, Hyperplasia             |             2        1                                      3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                        1                    1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  I  M  +  M  +  +  +  +  I  +  +  M  +  +  +  +  +  M|             
      Cyst                                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  I  +  I|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |          +                                                               |             
      Inflammation, Suppurative            |          4                                                               |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Penis                                   |          M                                                               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                                                     +         |             
      Inflammation, Suppurative            |          4                                                     4         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |             1                                                            |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |          3                                                               |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2     1     2  2     2  1  2  1     2  2     1  2  2  1  1     2  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   3        2                             3  3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 118                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 4| 1| 2| 2| 2| 2| 1| 3| 2| 1| 2| 4| 3| 2| 2| 2| 4| 2| 2| 3| 2|             
                             DAY ON TEST   | 1| 5| 2| 3| 1| 8| 7| 7| 2| 5| 6| 0| 1| 8| 9| 1| 1| 4| 5| 4| 2| 4| 5| 0| 8|             
                                           | 6| 8| 2| 8| 4| 2| 3| 7| 3| 7| 7| 6| 8| 0| 7| 2| 9| 3| 0| 9| 2| 3| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    625 PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 1| 3| 4| 1| 2| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 2| 3| 4| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Megakaryocyte |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                           2                              |             
      Renal, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  I  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  M|             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Plasma Cell             |                            3                             4               |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                            2              2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  +  I  +  +  +  M  M  +  +  +  M  +  +  M  +  +  +|             
      Congestion                           |                                                          2               |             
      Hematopoietic Cell Proliferation     |                                                                   1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Hemorrhage                           |                      1                                                   |             
      Hyperplasia, Histiocytic             |                                                          2               |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |             1                                            2  1     2      |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  M  +  +  I  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
      Necrosis                             |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  +  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          3                                                               |             
      Necrosis                             |                                                             3            |             
      Hair Follicle, Inflammation,         |                                                                          |             
          Suppurative                      |          1                                                               |             
      Prepuce, Inflammation, Suppurative   |          4                                                               |             
      Subcutaneous Tissue, Hemorrhage      |    3                                                                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |             3                                               3            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 119                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 4| 1| 2| 2| 2| 2| 1| 3| 2| 1| 2| 4| 3| 2| 2| 2| 4| 2| 2| 3| 2|             
                             DAY ON TEST   | 1| 5| 2| 3| 1| 8| 7| 7| 2| 5| 6| 0| 1| 8| 9| 1| 1| 4| 5| 4| 2| 4| 5| 0| 8|             
                                           | 6| 8| 2| 8| 4| 2| 3| 7| 3| 7| 7| 6| 8| 0| 7| 2| 9| 3| 0| 9| 2| 3| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    625 PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 1| 3| 4| 1| 2| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 2| 3| 4| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   1  1                       1                           |             
      Mineralization                       |                                  1           1              1            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +        +                 +                       +         |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2  2                 2                    1           2     1            |             
      Thrombosis                           |                      3                                                   |             
      Alveolar Epithelium, Hyperplasia     |             2                          3     2              3            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    3                                                                     |             
      Alveolus, Pigmentation, Hemosiderin  |    3                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             1                                                            |             
      Olfactory Epithelium, Atrophy        |                   1                                                      |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  M  +  +  M  +  M  M  M  M  +  M  +  +  +  +  M  M  M  +  M  M  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      1              2                                    |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |          2                                                               |             
      Nephropathy                          |                                                                          |             
      Papilla, Necrosis                    |          2                                                               |             
      Pelvis, Hyperplasia                  |                                                                          |             
      Pelvis, Mineralization               |                               1                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 120                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 4| 1| 2| 2| 2| 2| 1| 3| 2| 1| 2| 4| 3| 2| 2| 2| 4| 2| 2| 3| 2|             
                             DAY ON TEST   | 1| 5| 2| 3| 1| 8| 7| 7| 2| 5| 6| 0| 1| 8| 9| 1| 1| 4| 5| 4| 2| 4| 5| 0| 8|             
                                           | 6| 8| 2| 8| 4| 2| 3| 7| 3| 7| 7| 6| 8| 0| 7| 2| 9| 3| 0| 9| 2| 3| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    625 PPM                                | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|             
                                           | 1| 3| 4| 1| 2| 4| 5| 1| 2| 3| 5| 2| 3| 4| 5| 1| 2| 3| 4| 2| 3| 4| 5| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |          3                                                               |             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 121                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 3| 2| 2| 2| 1| 2| 2| 2| 2| 2| 3| 1| 1| 2| 2| 2| 2| 3| 2| 2|     |            |
                             DAY ON TEST   | 9| 8| 9| 7| 1| 4| 6| 9| 2| 8| 6| 3| 7| 1| 8| 2| 4| 2| 5| 3| 1| 6| 6|     |            |
                                           | 5| 5| 9| 6| 5| 7| 4| 2| 8| 9| 0| 9| 1| 0| 7| 0| 0| 2| 4| 6| 5| 4| 0|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     |      A     |
    625 PPM                                | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     |      L     |
                                           | 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 4| 5|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  M  +  +  A  A  +  +  +  A  +  +  A  +  +  A  +  +  A  M      |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  65        |
      Anus, Inflammation, Suppurative      | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  A  +  +  A  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +      |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  A  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +      |  61        |
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  61        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  A  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +      |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  M  +  A  +  A  A  A  +  +  +  A  +  +  A  +  +  +  +  +  +  +      |  51        |
      Hemorrhage                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  A  +  A  A  I  +  +  +  A  +  +  A  +  +  A  +  +  +  +      |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  A  A  +  M  A  +  +  A  +  +  +  +  A  +  +  +  +  +  A  +      |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  72        |
      Basophilic Focus                     |                         X                                                |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      5  1.0|
      Hyperplasia, Focal                   |          3                                                               |      1  3.0|
      Mineralization                       |                                                                          |      2  1.5|
      Necrosis                             |          1           2        1     1        2                           |     19  1.7|
      Centrilobular, Degeneration, Fatty   |                1                                      2                  |      5  1.8|
      Centrilobular, Necrosis              |                                        2              2                  |      6  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   4        |
      Fat, Hemorrhage                      |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  72        |
      Acinus, Focal Cellular Change        |                                                                          |      1  2.0|
      Acinus, Inflammation, Chronic        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |  69        |
      Hemorrhage                           |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  72        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  72        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Ulcer                                |          1                                                               |      9  1.2|
      Epithelium, Hyperplasia              |    1  2  3        1  2     1  2     3  2                    2     1      |     40  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  66        |
      Mineralization                       |                                                                          |      1  1.0|
      Pigmentation, Hemosiderin            | 1           1     1                                                      |      7  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 122                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 3| 2| 2| 2| 1| 2| 2| 2| 2| 2| 3| 1| 1| 2| 2| 2| 2| 3| 2| 2|     |            |
                             DAY ON TEST   | 9| 8| 9| 7| 1| 4| 6| 9| 2| 8| 6| 3| 7| 1| 8| 2| 4| 2| 5| 3| 1| 6| 6|     |            |
                                           | 5| 5| 9| 6| 5| 7| 4| 2| 8| 9| 0| 9| 1| 0| 7| 0| 0| 2| 4| 6| 5| 4| 0|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     |      A     |
    625 PPM                                | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     |      L     |
                                           | 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 4| 5|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
      Cardiomyopathy                       |                                                                          |      2  1.5|
      Hemorrhage                           |                            3                                             |      2  2.0|
      Mineralization                       |             2  2  2        2     3                    2     2  2         |     20  1.9|
      Necrosis                             |                                                          1               |      1  1.0|
      Atrium, Thrombosis                   |                                                       2                  |      3  2.0|
      Endothelium, Hyperplasia             |                                                                          |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
      Hypertrophy                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |  69        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +      |  70        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +      |  55        |
      Cyst                                 |                            X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  M  +  +      |  62        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  70        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  71        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  66        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 123                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 3| 2| 2| 2| 1| 2| 2| 2| 2| 2| 3| 1| 1| 2| 2| 2| 2| 3| 2| 2|     |            |
                             DAY ON TEST   | 9| 8| 9| 7| 1| 4| 6| 9| 2| 8| 6| 3| 7| 1| 8| 2| 4| 2| 5| 3| 1| 6| 6|     |            |
                                           | 5| 5| 9| 6| 5| 7| 4| 2| 8| 9| 0| 9| 1| 0| 7| 0| 0| 2| 4| 6| 5| 4| 0|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     |      A     |
    625 PPM                                | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     |      L     |
                                           | 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 4| 5|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  67        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  72        |
      Atrophy                              | 2  1  1     2  2  2     2  3  1  2  2  2  2     2  2  2  2  3     2      |     53  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
      Atrophy                              |                   3  4                 4              3        3         |     23  2.8|
      Infiltration Cellular, Megakaryocyte |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
      Necrosis                             |                                                                          |      1  2.0|
      Renal, Mineralization                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  M  M  +  M  +  +  +  +  M  M  M  +  M  +  +  +  +  +  +  +      |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +      |  61        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                        2                                 |      2  3.0|
      Hyperplasia, Plasma Cell             |                                                       4                  |      4  3.5|
      Mineralization                       |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |  58        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  68        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Histiocytic             |                                        2                                 |      3  2.7|
      Inflammation                         |                                                                          |      1  3.0|
      Necrosis                             |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  70        |
      Depletion Lymphoid                   |                                        3                                 |      2  3.0|
      Hematopoietic Cell Proliferation     |                   2           3                       2                  |     14  1.9|
      Hyperplasia, Histiocytic             |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  64        |
      Hyperplasia, Neutrophil              |                                        2                                 |      1  2.0|
      Necrosis                             | 2  2                          2     3        3        3                  |     12  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 124                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 3| 2| 2| 2| 1| 2| 2| 2| 2| 2| 3| 1| 1| 2| 2| 2| 2| 3| 2| 2|     |            |
                             DAY ON TEST   | 9| 8| 9| 7| 1| 4| 6| 9| 2| 8| 6| 3| 7| 1| 8| 2| 4| 2| 5| 3| 1| 6| 6|     |            |
                                           | 5| 5| 9| 6| 5| 7| 4| 2| 8| 9| 0| 9| 1| 0| 7| 0| 0| 2| 4| 6| 5| 4| 0|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     |      A     |
    625 PPM                                | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     |      L     |
                                           | 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 4| 5|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  I  M  +  M  +      |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
      Acanthosis                           |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Hair Follicle, Inflammation,         |                                                                          |            |
          Suppurative                      |                                                                          |      1  1.0|
      Prepuce, Inflammation, Suppurative   |                                                                          |      1  4.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
      Hemorrhage                           |                1  1  1              1  3                                 |     12  1.2|
      Mineralization                       |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                            +     +     +           +        +            |  12        |
      Hemorrhage                           |                                        1                                 |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  71        |
      Hyperplasia                          |                                                             1            |      1  1.0|
      Inflammation                         |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
      Hemorrhage                           |                2                    1        1           1     1         |     12  1.5|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     | 1        2                    1                                   1      |     12  1.9|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
      Alveolus, Pigmentation, Hemosiderin  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  71        |
      Inflammation, Suppurative            |                                                                          |      2  1.5|
      Olfactory Epithelium, Atrophy        |                         2                                                |      4  1.8|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 125                                                               
NTP Experiment-Test: 05134-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           1,3-BUTADIENE                                       Date: 07/08/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:22:13  
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 3| 2| 2| 2| 1| 2| 2| 2| 2| 2| 3| 1| 1| 2| 2| 2| 2| 3| 2| 2|     |            |
                             DAY ON TEST   | 9| 8| 9| 7| 1| 4| 6| 9| 2| 8| 6| 3| 7| 1| 8| 2| 4| 2| 5| 3| 1| 6| 6|     |            |
                                           | 5| 5| 9| 6| 5| 7| 4| 2| 8| 9| 0| 9| 1| 0| 7| 0| 0| 2| 4| 6| 5| 4| 0|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     |      A     |
    625 PPM                                | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     |      L     |
                                           | 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 4| 5| 1| 2| 3| 4| 5|     |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  67        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                          +                     |   5        |
      Degeneration                         |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  +  M  M  M  M  +  +  +  +  M  +  M  M  M  M  M  +  +  +  +      |  40        |
      Hyperplasia                          |                                                             2            |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  73        |
      Hemorrhage                           |                                                                          |      2  1.5|
      Hydronephrosis                       | 2                                                                        |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nephropathy                          |                1                                            1            |      3  1.3|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Pelvis, Hyperplasia                  |                                                                          |      2  1.5|
      Pelvis, Mineralization               |                                                                          |      3  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  3.0|
      Renal Tubule, Mineralization         |                                                                2         |      4  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  66        |
      Dilatation                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      3  1.7|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 126                                                               
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