TDMS Study 05135-07 Pathology Tables
NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 2 YEAR CHRONIC Facility: Battelle Northwest Chemical CAS #: 78-79-5 Lock Date: 03/13/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Natural Death 5 5 4 Moribund Sacrifice 16 15 18 23 Survivors Terminal Sacrifice 29 30 28 27 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Ileum (49) (47) (46) (50) Inflammation, Chronic Active 1 (2%) Liver (50) (50) (50) (50) Angiectasis 2 (4%) 2 (4%) 3 (6%) 4 (8%) Basophilic Focus 36 (72%) 38 (76%) 33 (66%) 33 (66%) Clear Cell Focus 9 (18%) 11 (22%) 10 (20%) 11 (22%) Degeneration, Cystic 1 (2%) 1 (2%) Degeneration, Fatty 1 (2%) Eosinophilic Focus 2 (4%) 3 (6%) 1 (2%) 4 (8%) Fatty Change 8 (16%) 6 (12%) 11 (22%) 9 (18%) Fibrosis 1 (2%) Hepatodiaphragmatic Nodule 2 (4%) 4 (8%) 5 (10%) 6 (12%) Inflammation, Granulomatous 1 (2%) Mixed Cell Focus 4 (8%) 10 (20%) 10 (20%) 5 (10%) Necrosis 1 (2%) Regeneration 1 (2%) 2 (4%) 3 (6%) Bile Duct, Cyst 1 (2%) 1 (2%) Bile Duct, Hyperplasia 3 (6%) 9 (18%) 9 (18%) 10 (20%) Centrilobular, Necrosis 5 (10%) 5 (10%) 8 (16%) 3 (6%) Periportal, Infiltration Cellular, Lymphocyte 1 (2%) Mesentery (9) (10) (8) (11) Fat, Necrosis 9 (100%) 10 (100%) 8 (100%) 11 (100%) Oral Mucosa (1) (1) Pharyngeal, Hyperplasia, Squamous 1 (100%) Pancreas (50) (50) (50) (50) Atrophy 18 (36%) 13 (26%) 11 (22%) 20 (40%) Basophilic Focus 1 (2%) 3 (6%) 3 (6%) Hyperplasia 2 (4%) Metaplasia, Hepatocyte 2 (4%) 1 (2%) Salivary Glands (50) (50) (50) (50) Atrophy 1 (2%) 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Diverticulum 1 (2%) Hyperplasia, Squamous 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Necrosis 5 (10%) 2 (4%) 7 (14%) 3 (6%) Stomach, Glandular (50) (49) (50) (50) Mineralization 1 (2%) Necrosis 3 (6%) 3 (6%) 4 (8%) 6 (12%) Tongue (1) (2) Hyperplasia 1 (50%) Tooth (1) (1) Developmental Malformation 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Cardiomyopathy 35 (70%) 33 (66%) 28 (56%) 37 (74%) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Atrophy 1 (2%) Degeneration, Cystic 1 (2%) 1 (2%) 3 (6%) Ectopic Tissue 1 (2%) Hyperplasia 25 (50%) 17 (34%) 20 (40%) 13 (26%) Hypertrophy 9 (18%) 14 (28%) 8 (16%) 14 (28%) Inflammation, Granulomatous 1 (2%) Necrosis 2 (4%) 1 (2%) Thrombosis 1 (2%) Vacuolization Cytoplasmic 4 (8%) 6 (12%) 4 (8%) 6 (12%) Adrenal Medulla (50) (50) (50) (50) Hyperplasia 11 (22%) 6 (12%) 9 (18%) 9 (18%) Islets, Pancreatic (49) (50) (50) (50) Hyperplasia 2 (4%) 1 (2%) 2 (4%) Parathyroid Gland (48) (43) (43) (45) Hyperplasia 1 (2%) Pituitary Gland (50) (50) (50) (50) Pars Distalis, Hyperplasia 12 (24%) 16 (32%) 7 (14%) 12 (24%) Thyroid Gland (48) (50) (49) (50) C-Cell, Hyperplasia 40 (83%) 32 (64%) 38 (78%) 40 (80%) Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (47) (48) (46) (48) Hyperplasia 2 (4%) 4 (8%) 2 (4%) 3 (6%) Inflammation, Chronic Active 1 (2%) Ovary (50) (50) (50) (50) Cyst 5 (10%) 3 (6%) 5 (10%) 6 (12%) Inflammation, Granulomatous 1 (2%) 2 (4%) Uterus (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (49) (50) (50) Atrophy 1 (2%) Hyperplasia, Histiocytic 1 (2%) Hyperplasia, Reticulum Cell 1 (2%) Myelofibrosis 1 (2%) 1 (2%) Spleen (50) (50) (50) (50) Fibrosis 4 (8%) 6 (12%) 10 (20%) 4 (8%) Hematopoietic Cell Proliferation 4 (8%) 5 (10%) 1 (2%) Hemorrhage 1 (2%) 2 (4%) 4 (8%) Metaplasia, Osseous 1 (2%) Necrosis 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Galactocele 1 (2%) 1 (2%) 1 (2%) Hyperplasia 1 (2%) 2 (4%) Skin (50) (50) (50) (50) Cyst Epithelial Inclusion 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Fibrous Osteodystrophy 1 (2%) Hyperostosis 6 (12%) 8 (16%) 11 (22%) 8 (16%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Degeneration, Focal 1 (2%) 1 (2%) Gliosis 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Inflammation, Chronic Active 31 (62%) 29 (58%) 25 (50%) 19 (38%) Alveolar Epithelium, Hyperplasia 5 (10%) 5 (10%) 10 (20%) 8 (16%) Nose (50) (50) (50) (50) Foreign Body 1 (2%) 1 (2%) 1 (2%) 4 (8%) Inflammation, Suppurative 5 (10%) 8 (16%) 8 (16%) 12 (24%) Thrombosis 2 (4%) 2 (4%) 3 (6%) 1 (2%) Olfactory Epithelium, Atrophy 1 (2%) 2 (4%) 2 (4%) Olfactory Epithelium, Hyperplasia 1 (2%) Olfactory Epithelium, Metaplasia 1 (2%) 2 (4%) 1 (2%) 1 (2%) Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%) Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (5) (4) (3) (6) Cataract 5 (100%) 3 (75%) 3 (100%) 4 (67%) Degeneration 1 (25%) 1 (17%) Hemorrhage 1 (17%) Retina, Atrophy 5 (100%) 2 (50%) 3 (100%) 4 (67%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (50) (50) Cyst 1 (2%) 1 (2%) Hydronephrosis 1 (2%) Infarct 1 (2%) 1 (2%) Nephropathy 46 (92%) 47 (96%) 48 (96%) 47 (94%) Papilla, Necrosis 1 (2%) Renal Tubule, Hyperplasia 4 (8%) Renal Tubule, Necrosis 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) Urinary Bladder (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 28 29 30 30 Natural Death 4 5 5 5 Survivors Moribund Sacrifice 1 Terminal Sacrifice 18 16 14 15 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Rectum (47) (49) (46) (50) Inflammation, Acute 2 (4%) Intestine Large, Cecum (48) (47) (46) (50) Diverticulum 1 (2%) Inflammation, Acute 1 (2%) Mineralization 1 (2%) Intestine Small, Duodenum (49) (49) (48) (49) Inflammation, Acute 1 (2%) 1 (2%) 1 (2%) Necrosis 1 (2%) 1 (2%) 2 (4%) 2 (4%) Intestine Small, Ileum (46) (47) (47) (49) Inflammation, Chronic Active 1 (2%) Necrosis 1 (2%) Liver (50) (50) (50) (50) Angiectasis 2 (4%) 5 (10%) 3 (6%) Basophilic Focus 17 (34%) 13 (26%) 13 (26%) 16 (32%) Clear Cell Focus 6 (12%) 9 (18%) 7 (14%) 8 (16%) Degeneration, Cystic 9 (18%) 9 (18%) 14 (28%) 17 (34%) Eosinophilic Focus 2 (4%) 4 (8%) 3 (6%) 3 (6%) Fatty Change 15 (30%) 12 (24%) 9 (18%) 11 (22%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hepatodiaphragmatic Nodule 1 (2%) 1 (2%) 4 (8%) 4 (8%) Infarct 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic Active 1 (2%) Inflammation, Granulomatous 1 (2%) Mineralization 1 (2%) Mixed Cell Focus 1 (2%) Necrosis 1 (2%) 1 (2%) 1 (2%) Regeneration 2 (4%) 2 (4%) 6 (12%) Artery, Inflammation, Chronic Active 1 (2%) Bile Duct, Hyperplasia 25 (50%) 32 (64%) 36 (72%) 29 (58%) Centrilobular, Necrosis 7 (14%) 11 (22%) 10 (20%) 9 (18%) Mesentery (8) (12) (11) (11) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Thrombosis 1 (9%) Artery, Mineralization 1 (9%) 2 (18%) Fat, Hemorrhage 1 (13%) 1 (8%) 1 (9%) 1 (9%) Fat, Inflammation, Chronic Active 1 (9%) 1 (9%) Fat, Necrosis 6 (75%) 10 (83%) 8 (73%) 6 (55%) Oral Mucosa (1) (1) Pharyngeal, Hyperplasia, Squamous 1 (100%) Pancreas (50) (50) (50) (50) Atrophy 18 (36%) 23 (46%) 23 (46%) 15 (30%) Basophilic Focus 1 (2%) 4 (8%) 1 (2%) 3 (6%) Hyperplasia 4 (8%) 6 (12%) 9 (18%) 7 (14%) Salivary Glands (50) (50) (50) (50) Atrophy 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Fibrosis 1 (2%) Hyperplasia, Squamous 1 (2%) 1 (2%) 1 (2%) Inflammation, Acute 1 (2%) 1 (2%) Mineralization 2 (4%) Necrosis 14 (28%) 8 (16%) 10 (20%) 12 (24%) Stomach, Glandular (50) (50) (50) (50) Mineralization 5 (10%) 1 (2%) 4 (8%) 4 (8%) Necrosis 6 (12%) 3 (6%) 7 (14%) 9 (18%) Tongue (1) (1) Hyperplasia 1 (100%) Tooth (1) Developmental Malformation 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) (2) (3) Inflammation 1 (100%) Aorta, Mineralization 2 (100%) 3 (100%) Endothelium, Hyperplasia 1 (100%) Heart (50) (50) (50) (50) Cardiomyopathy 41 (82%) 44 (88%) 44 (88%) 38 (76%) Artery, Mineralization 1 (2%) 2 (4%) 4 (8%) Atrium, Thrombosis 4 (8%) 3 (6%) 3 (6%) 5 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Atrophy 1 (2%) 1 (2%) Degeneration, Cystic 1 (2%) Hyperplasia 23 (46%) 23 (46%) 19 (38%) 20 (40%) Hypertrophy 8 (16%) 11 (22%) 4 (8%) 4 (8%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Necrosis 1 (2%) Thrombosis 1 (2%) Vacuolization Cytoplasmic 2 (4%) 6 (12%) 3 (6%) 6 (12%) Adrenal Medulla (50) (50) (50) (50) Angiectasis 1 (2%) Hyperplasia 19 (38%) 19 (38%) 25 (50%) 21 (42%) Thrombosis 1 (2%) Bilateral, Hyperplasia 2 (4%) Islets, Pancreatic (50) (50) (50) (49) Hyperplasia 1 (2%) 3 (6%) Parathyroid Gland (48) (46) (45) (47) Cyst 1 (2%) Hyperplasia 5 (10%) 6 (13%) 8 (18%) 13 (28%) Pituitary Gland (50) (50) (50) (49) Pars Distalis, Hyperplasia 5 (10%) 6 (12%) 9 (18%) 11 (22%) Pars Intermedia, Hyperplasia 1 (2%) Thyroid Gland (49) (50) (49) (50) C-Cell, Hyperplasia 30 (61%) 30 (60%) 30 (61%) 34 (68%) Follicular Cell, Hyperplasia 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Granuloma Sperm 1 (2%) 1 (2%) Preputial Gland (50) (50) (50) (50) Hyperplasia 1 (2%) 1 (2%) Inflammation, Chronic Active 3 (6%) 1 (2%) 1 (2%) 3 (6%) Prostate (50) (50) (50) (50) Hyperplasia 11 (22%) 13 (26%) 15 (30%) 17 (34%) Inflammation, Chronic Active 5 (10%) 2 (4%) 1 (2%) 6 (12%) Seminal Vesicle (47) (48) (47) (50) Inflammation, Chronic Active 1 (2%) Testes (50) (50) (50) (50) Atrophy 1 (2%) 1 (2%) 1 (2%) Artery, Inflammation, Chronic Active 6 (12%) 2 (4%) 1 (2%) Interstitial Cell, Hyperplasia 15 (30%) 13 (26%) 8 (16%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (49) (50) Hyperplasia, Histiocytic 1 (2%) Myelofibrosis 1 (2%) Necrosis 2 (4%) Lymph Node (6) (7) (7) (9) Iliac, Ectasia 1 (17%) Renal, Hemorrhage 1 (11%) Lymph Node, Mandibular (49) (46) (46) (44) Infiltration Cellular, Plasma Cell 2 (4%) Lymph Node, Mesenteric (50) (49) (49) (50) Infiltration Cellular, Plasma Cell 1 (2%) Spleen (50) (50) (50) (50) Depletion Cellular 1 (2%) Fibrosis 11 (22%) 14 (28%) 24 (48%) 22 (44%) Hematopoietic Cell Proliferation 3 (6%) 3 (6%) 1 (2%) 5 (10%) Hemorrhage 1 (2%) Necrosis 3 (6%) 2 (4%) 1 (2%) Thymus (47) (44) (49) (47) Atrophy 1 (2%) Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (42) (43) (47) (44) Galactocele 2 (5%) 4 (9%) 2 (4%) 3 (7%) Inflammation, Chronic 1 (2%) Skin (50) (50) (50) (50) Cyst Epithelial Inclusion 2 (4%) 2 (4%) Inflammation, Chronic Active 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Fibrous Osteodystrophy 2 (4%) 1 (2%) 6 (12%) 7 (14%) Hyperostosis 1 (2%) 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Degeneration, Focal 1 (2%) Gliosis 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (50) (50) Inflammation, Chronic, Focal 1 (2%) Inflammation, Chronic Active 21 (43%) 16 (32%) 22 (44%) 15 (30%) Mineralization 2 (4%) 2 (4%) Thrombosis 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 7 (14%) 11 (22%) 4 (8%) 10 (20%) Artery, Mediastinum, Mineralization 2 (4%) 2 (4%) Nose (50) (50) (49) (50) Foreign Body 4 (8%) 4 (8%) 3 (6%) 2 (4%) Inflammation, Suppurative 11 (22%) 9 (18%) 10 (20%) 9 (18%) Thrombosis 2 (4%) 4 (8%) 10 (20%) 5 (10%) Olfactory Epithelium, Atrophy 1 (2%) 8 (16%) 2 (4%) Olfactory Epithelium, Metaplasia 7 (14%) 2 (4%) 1 (2%) 2 (4%) Olfactory Epithelium, Metaplasia, Squamous 1 (2%) Respiratory Epithelium, Hyperplasia 2 (4%) 2 (4%) 2 (4%) Respiratory Epithelium, Metaplasia, Squamous 1 (2%) Trachea (50) (50) (50) (50) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (3) (3) (2) Cataract 1 (100%) 1 (33%) 3 (100%) 2 (100%) Hemorrhage 1 (33%) Cornea, Inflammation, Chronic Active 1 (33%) 1 (33%) Retina, Atrophy 1 (100%) 2 (67%) 3 (100%) 2 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Cyst 2 (4%) 4 (8%) 2 (4%) Infarct 1 (2%) 1 (2%) 2 (4%) Mineralization 2 (4%) 3 (6%) Nephropathy 50 (100%) 50 (100%) 50 (100%) 49 (98%) Renal Tubule, Hyperplasia 2 (4%) 6 (12%) 8 (16%) Urinary Bladder (50) (49) (50) (50) Hemorrhage 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) Necrosis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05135-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ISOPRENE Date: 09/24/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:49:08 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 220 PPM 700 PPM 7000 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------