TDMS Study 05136-08 Pathology Tables
NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 Facility: Battelle Northwest Chemical CAS #: 0000126-99-8 Lock Date: 04/14/94 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + M + + + + + + + M + + + + + + + + M + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | | Lymphoma Malignant | X X | __________________________________________________________________________| Mesentery | + + + + + + | Lymphoma Malignant | X | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +| Hemangiosarcoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Parathyroid Gland | M M + + + + + + + M + + + + + M + M M M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + M + M M + M + + + + + + M + + + + + +| __________________________________________________________________________| Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node | + | Pancreatic, Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + M + + + M M + + + + + + M + M M M M + +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + M M + + + M M M + + + M + M M M + M + M + +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M M + + + M + + + + + M + M + + + + + M| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant | X X | __________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + + + + M M + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Carcinoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Subcutaneous Tissue, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Harderian | | Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Ureter | | __________________________________________________________________________| Urethra | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Hepatocellular Carcinoma | X X | 4 | Hepatocellular Adenoma | X X X X X X | 12 | Hepatocellular Adenoma, Multiple | X X X X X | 5 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Mesentery | + + + + | 10 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + M + M + + + + + + M + + M M + + + + M + M| 35 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X | 4 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M + + I + + + + + M + + + + + + + + +| 41 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | Cystadenoma | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | | 1 | Polyp Stromal | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + | 4 | Pancreatic, Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + + M + + + I + + M + M + + + + + + M M M +| 32 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + I + + + + M + M + + + + + M + + M + + + M M +| 32 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M M M + M + + M + + + + + + M +| 38 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X | 6 | __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + M + + + + + + + + + M + +| 44 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Carcinoma | X X| 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | Basal Cell Adenoma | | 1 | Subcutaneous Tissue, Hemangiosarcoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Alveolar/Bronchiolar Carcinoma | X X | 2 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 2 | Adenoma | | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Ureter | + | 1 | __________________________________________________________________________|____________| Urethra | + | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6| DAY ON TEST | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3| | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + A M + + + + + + + + A + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + A + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + A + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + A + + + + + + + + + + A +| Peyer's Patch, Lymphoma Malignant | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X X X X | Hepatocellular Adenoma, Multiple | X X | Hepatocholangiocarcinoma | | Histiocytic Sarcoma | X | Lymphoma Malignant | X X | Sarcoma, Metastatic, Mesentery | X | __________________________________________________________________________| Mesentery | + + + + + + + | Hemangiosarcoma | X X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X | Sarcoma | X X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Sarcoma, Metastatic, Mesentery | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +| Sarcoma, Metastatic, Mesentery | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + M + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6| DAY ON TEST | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3| | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M M M + + + + + M + M + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Pars Distalis, Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + M M + + + + M + + + + M + + M + M + +| __________________________________________________________________________| Ovary | + + + + + + + + + I + + + + + I + + + + + + + + +| Cystadenoma | X | Histiocytic Sarcoma | X | Luteoma | X | Lymphoma Malignant | X X | Teratoma Malignant | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leiomyosarcoma | | Polyp Stromal | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node | + + + | Lymphoma Malignant | X | Iliac, Lymphoma Malignant | X X | Pancreatic, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Bronchial | M M M M + + M + + + + + + + + M M M + + + M + + +| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + M M + + + + + + + + M M +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | X X X | Sarcoma, Metastatic, Mesentery | X | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6| DAY ON TEST | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3| | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + M + + + M + + + M + + M + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + M M M + + + + + + +| Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoacanthoma | X | Adenoma | | Carcinoma | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | Subcutaneous Tissue, Histiocytic | | Sarcoma | X | Subcutaneous Tissue, Lymphoma | | Malignant | X | Subcutaneous Tissue, Sarcoma | X X X X X X X| Subcutaneous Tissue, Sarcoma, | | Multiple | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X| Alveolar/Bronchiolar Adenoma, | | Multiple | X X X X | Alveolar/Bronchiolar Carcinoma | X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X | Carcinoma, Metastatic, Harderian | | Gland | X | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6| DAY ON TEST | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3| | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hemangiosarcoma, Metastatic, | | Mesentery | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X X | Sarcoma, Metastatic, Skin | X | Mediastinum, Sarcoma, Metastatic, | | Skin | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3| | DAY ON TEST | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2| | | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + A| 48 | __________________________________________________________________________|____________| Gallbladder | + + + + + + A + + + + + + + + + + + + + + + + + A| 44 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + A| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + A| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 | Peyer's Patch, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hepatocellular Carcinoma | X X X X X X | 10 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X | 12 | Hepatocellular Adenoma, Multiple | X X X X X | 7 | Hepatocholangiocarcinoma | X | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X | 3 | Sarcoma, Metastatic, Mesentery | | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + + + | 14 | Hemangiosarcoma | X X | 4 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | | 1 | Sarcoma | X | 4 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Sarcoma, Metastatic, Mesentery | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | Sarcoma, Metastatic, Mesentery | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3| | DAY ON TEST | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2| | | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Pheochromocytoma Malignant | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M + M M + + + + M + + + M M + + + + + M + M| 35 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | Pars Distalis, Adenoma | X X X X | 6 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + M + + + + + + + M + + + + A| 40 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | Cystadenoma | | 1 | Histiocytic Sarcoma | X | 2 | Luteoma | | 1 | Lymphoma Malignant | | 2 | Teratoma Malignant | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Histiocytic Sarcoma | X | 2 | Leiomyosarcoma | X | 1 | Polyp Stromal | X | 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node | | 3 | Lymphoma Malignant | | 1 | Iliac, Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3| | DAY ON TEST | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2| | | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Lymphoma Malignant | | 1 | Renal, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + + M + + + M + M + + + M + + + M M M + + A| 31 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + M + + + + + M + + M + + + + + + M A| 40 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + M + + + M + + A| 45 | Hemangiosarcoma | X | 2 | Lymphoma Malignant | | 3 | Sarcoma, Metastatic, Mesentery | | 1 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + M| 44 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | X X | 5 | __________________________________________________________________________|____________| Thymus | M M M M + + + + + + + M + + + M M + M M + + + M M| 35 | Lymphoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Adenoacanthoma | | 1 | Adenoma | X | 1 | Carcinoma | X X | 4 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant | | 1 | Subcutaneous Tissue, Sarcoma | X X X | 10 | Subcutaneous Tissue, Sarcoma, | | | Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3| | DAY ON TEST | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2| | | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Alveolar/Bronchiolar Adenoma | X X X X | 10 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X | 6 | Alveolar/Bronchiolar Carcinoma | X X X X | 8 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X X X | 6 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | X | 3 | Sarcoma, Metastatic, Skin | X | 2 | Mediastinum, Sarcoma, Metastatic, | | | Skin | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + + | 6 | Adenoma | X X | 3 | Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3| | DAY ON TEST | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2| | | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6| DAY ON TEST | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0| | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + M + + A + + + + + M + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | __________________________________________________________________________| Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + I + + + + + + A + + + + A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + A + A + + + + A + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + A + + + + A + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | X X X X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X | Hepatocholangiocarcinoma | X | Histiocytic Sarcoma | | Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | | __________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | X X X X X X X X X | Histiocytic Sarcoma | | Lymphoma Malignant | X | Sarcoma | X X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, | | Mesentery | X | Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Sarcoma, Metastatic, Skin | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6| DAY ON TEST | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0| | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hemangiosarcoma, Metastatic, | | Mesentery | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Parathyroid Gland | M + + M + + + + + M + M + M + M + + + M + M + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + M + + + + + +| Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | Thyroglossal Duct, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + M + M + M + + + + M + + + + + I + + + + M M| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + M M| Cystadenoma | | Histiocytic Sarcoma | | Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | Histiocytic Sarcoma | | Lymphoma Malignant | X | Polyp Stromal | X | __________________________________________________________________________| Vagina | | Sarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node | + | Lymphoma Malignant | | Iliac, Hemangiosarcoma, Metastatic, | | Mesentery | | Iliac, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M + M M + + M + M M + M + M + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6| DAY ON TEST | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0| | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mandibular | + + + I + + + M + M + M M M I M + M + + + + + M M| Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hemangiosarcoma, Metastatic, | | Mesentery | X X | Histiocytic Sarcoma | | Lymphoma Malignant | X | Sarcoma | X | Sarcoma, Metastatic, Mesentery | X | Sarcoma, Metastatic, Intestine Large,| | Colon | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + M + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + M + + M + + M + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoacanthoma | X X | Adenoma | | Carcinoma | | Carcinoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Sarcoma | X X X X X X X X| Subcutaneous Tissue, Sarcoma, | | Multiple | | Subcutaneous Tissue, Sarcoma, | | Metastatic, Mesentery | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Sarcoma, Metastatic, Mesentery | | Sarcoma, Metastatic, Skin | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6| DAY ON TEST | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0| | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoacanthoma, Metastatic, Mammary | | Gland | X X | Alveolar/Bronchiolar Adenoma | X X X X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X X X X | Alveolar/Bronchiolar Carcinoma | X X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X X | Carcinoma, Metastatic, Mammary Gland | | Hemangiosarcoma, Metastatic, | | Mesentery | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | | Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | X | Sarcoma, Metastatic, Skin | X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinum, Hemangiosarcoma | X | Mediastinum, Sarcoma, Metastatic, | | Mesentery | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Respiratory Epithelium, Adenoma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + +| Adenoma | X X| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, | | Mesentery | X | Histiocytic Sarcoma | | Lymphoma Malignant | | Sarcoma, Metastatic, Mesentery | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6| DAY ON TEST | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0| | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + A M + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | | Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6| | DAY ON TEST | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5| | | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + M + A + + + + + + + + + + + + + + + M + + A + +| 42 | __________________________________________________________________________|____________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + A + +| 48 | Sarcoma | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + A + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + A + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + A + + + + + + + + + + + + + + + + + + A + +| 42 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + A + + + + + + + + + + + + + + + + + + A + +| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + A + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X | 7 | Hepatocellular Carcinoma, Multiple | X X X | 7 | Hepatocellular Adenoma | X X X X | 9 | Hepatocellular Adenoma, Multiple | | 2 | Hepatocholangiocarcinoma | | 1 | Histiocytic Sarcoma | X X X | 3 | Lymphoma Malignant | X X | 3 | Sarcoma, Metastatic, Mesentery | X | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + | 27 | Hemangioma | X | 2 | Hemangiosarcoma | X X X X | 13 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 2 | Sarcoma | X X X X X | 8 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + M A + +| 48 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | Lymphoma Malignant | X | 2 | Sarcoma, Metastatic, Mesentery | X X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Skin | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Mesentery | X X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6| | DAY ON TEST | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5| | | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + I + + + + + + + + + + + + + A + +| 48 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M A + +| 48 | Adenoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + I M I + + + + M + M + + M M + + M + + M + M| 31 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Adenoma | X X X| 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Follicular Cell, Adenoma | X | 1 | Thyroglossal Duct, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M M + + M + M M + + M + + + M + + + M M + + + + M| 32 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 | Cystadenoma | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 2 | Sarcoma, Metastatic, Mesentery | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 2 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | | 1 | Polyp Stromal | X | 2 | __________________________________________________________________________|____________| Vagina | + | 1 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Hemangiosarcoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6| | DAY ON TEST | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5| | | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + | 5 | Lymphoma Malignant | X | 1 | Iliac, Hemangiosarcoma, Metastatic, | | | Mesentery | X | 1 | Iliac, Lymphoma Malignant | X | 2 | Renal, Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + M + + + + M + + + M M + + M + M + + M + +| 34 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + M M M + + + + M + M + + + +| 33 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + A + +| 48 | Hemangiosarcoma | | 1 | Hemangiosarcoma, Metastatic, | | | Mesentery | X | 3 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | X | 2 | Sarcoma | | 1 | Sarcoma, Metastatic, Mesentery | X X X | 4 | Sarcoma, Metastatic, Intestine Large,| | | Colon | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + M + + M + + + +| 45 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Thymus | + + + + M + + + M + M M M M + + M + + + + + A + +| 39 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoacanthoma | X | 3 | Adenoma | X | 1 | Carcinoma | X X X X X X | 6 | Carcinoma, Multiple | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangiosarcoma | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6| | DAY ON TEST | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5| | | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Subcutaneous Tissue, Sarcoma | X X | 10 | Subcutaneous Tissue, Sarcoma, | | | Multiple | X | 1 | Subcutaneous Tissue, Sarcoma, | | | Metastatic, Mesentery | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 2 | Sarcoma, Metastatic, Mesentery | X | 1 | Sarcoma, Metastatic, Skin | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoacanthoma, Metastatic, Mammary | | | Gland | X | 3 | Alveolar/Bronchiolar Adenoma | X X X X X X X X | 17 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X X X X X X | 12 | Alveolar/Bronchiolar Carcinoma | X X X | 8 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X X X X| 8 | Carcinoma, Metastatic, Mammary Gland | X X | 2 | Hemangiosarcoma, Metastatic, | | | Mesentery | X X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | X | 2 | Sarcoma, Metastatic, Mesentery | X | 2 | Sarcoma, Metastatic, Skin | | 1 | Mediastinum, Alveolar/Bronchiolar | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6| | DAY ON TEST | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5| | | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Carcinoma, Metastatic, Lung | X| 1 | Mediastinum, Hemangiosarcoma | | 1 | Mediastinum, Sarcoma, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Lymphoma Malignant | | 1 | Respiratory Epithelium, Adenoma | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 4 | Adenoma | X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Mesentery | X X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + A + +| 46 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Mesentery | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X X | 3 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3| DAY ON TEST | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2| | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + A + + + + + + + + + + + + M + + A + + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + M + + + + + + M + + + + + + + + + M + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X | Sarcoma, Metastatic, Mesentery | X | __________________________________________________________________________| Mesentery | + + + + + + + + + | Hemangioma | X | Hemangiosarcoma | X X | Sarcoma | X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Mesentery | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + M + + M M + + + + + + + + + M + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + M + + M M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3| DAY ON TEST | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2| | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X X | Polyp Stromal | X | Sarcoma, Metastatic, Mesentery | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + | Iliac, Sarcoma, Metastatic, Mesentery| X | __________________________________________________________________________| Lymph Node, Bronchial | + + + M + + + M + + + + + M + + M + + M + M + + +| Sarcoma, Metastatic, Mesentery | | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + M M + + + M + M + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + M + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + I + + + + + + + + + + + + M + + + M + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Sarcoma, Metastatic, Mesentery | | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thymus | + M M + + + I M + + + + + + + + + + + + + + + + M| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoacanthoma | X | Carcinoma | X X X | Carcinoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | Subcutaneous Tissue, Hemangiosarcoma | | Subcutaneous Tissue, Sarcoma | X X X X X X X X | Subcutaneous Tissue, Sarcoma, | | Multiple | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3| DAY ON TEST | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2| | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Sarcoma, Metastatic, Skin | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X X X X X | Alveolar/Bronchiolar Carcinoma | X X X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X X X X X X X X| Carcinoma, Metastatic, Mammary Gland | X | Carcinoma, Metastatic, Zymbal's Gland| X X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Sarcoma, Metastatic, Mesentery | | Sarcoma, Metastatic, Skin | X X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Mediastinum, Sarcoma, Metastatic, | | Mesentery | | Mediastinum, Sarcoma, Metastatic, | | Skin | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | +| __________________________________________________________________________| Harderian Gland | + + + + + + | Adenoma | X X X X X | Carcinoma | X | __________________________________________________________________________| Zymbal's Gland | + + | Carcinoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | I + + + A + + + + + + + + + + + + M + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6| | DAY ON TEST | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3| | | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + M + + + + + + M + + + + + + + + A + + M + +| 42 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X X X X X X X X X| 15 | Hepatocellular Carcinoma, Multiple | X X X | 4 | Hepatocellular Adenoma | X X | 7 | Hepatocellular Adenoma, Multiple | X X X X X X X | 9 | Sarcoma, Metastatic, Mesentery | X | 2 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + +| 21 | Hemangioma | | 1 | Hemangiosarcoma | X X| 4 | Sarcoma | X | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X| 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Mesentery | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M M + + + + M M + + M + + M + + M| 37 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X | 4 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6| | DAY ON TEST | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3| | | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + M + M + M + + M M M + + + + + M M + + + M + M| 35 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | | 2 | Polyp Stromal | X X | 3 | Sarcoma, Metastatic, Mesentery | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | | 2 | Iliac, Sarcoma, Metastatic, Mesentery| | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + M + + + M + + M M M + + + + + + + + + +| 38 | Sarcoma, Metastatic, Mesentery | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + + M + + M M + M + + + +| 40 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + M + + + + + +| 46 | Hemangiosarcoma | | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M + + M + M + + M M + M + + + +| 40 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Sarcoma, Metastatic, Mesentery | X | 1 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Thymus | + + M + M + + + + M + + + + M + + + + + + M + + M| 39 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoacanthoma | X | 2 | Carcinoma | X X X X X X X X | 11 | Carcinoma, Multiple | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | Subcutaneous Tissue, Sarcoma | X X X X X X X X | 16 | Subcutaneous Tissue, Sarcoma, | | | Multiple | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6| | DAY ON TEST | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3| | | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Sarcoma, Metastatic, Skin | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X | 10 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X X X X X X X X X| 16 | Alveolar/Bronchiolar Carcinoma | X X X X X | 11 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X X X X X X X | 17 | Carcinoma, Metastatic, Mammary Gland | X | 2 | Carcinoma, Metastatic, Zymbal's Gland| | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X | 4 | Sarcoma, Metastatic, Mesentery | X | 1 | Sarcoma, Metastatic, Skin | | 2 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | X | 2 | Mediastinum, Sarcoma, Metastatic, | | | Mesentery | X | 1 | Mediastinum, Sarcoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + | 9 | Adenoma | X X X | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6| | DAY ON TEST | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3| | | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Carcinoma | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 3 | Carcinoma | X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + M M + + + + I A + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| Muscularis, Leiomyoma | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + M + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + A + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + A + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X| Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | X X X X X X | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X X X X X X X | Histiocytic Sarcoma | X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + M + M + + + + + M + I + M M + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node, Bronchial | M + M M M + + M + + + + M + + + + + M + + + + M +| __________________________________________________________________________| Lymph Node, Mandibular | M M M + M M + M M + + M M + + M + + + M + + I + M| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + M M + + + M + M M + + + + + + M M M +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | __________________________________________________________________________| Thymus | M + M M M + + M M + + + + M I + M + + I + M + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X X X| Alveolar/Bronchiolar Carcinoma, | | Multiple | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Histiocytic Sarcoma | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Ureter | + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7| | DAY ON TEST | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3| | | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + M + + + M + + + + A + + + + A + A +| 41 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | Muscularis, Leiomyoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + A + M +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + A + + +| 46 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + A + + +| 46 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X| 2 | Hepatocellular Carcinoma | X X X X X | 10 | Hepatocellular Carcinoma, Multiple | X X X X X X X X | 14 | Hepatocellular Adenoma | X X X X X X X | 8 | Hepatocellular Adenoma, Multiple | X X X X X X X| 14 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Mesentery | + + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tooth | + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + M M + + + + M + I + M + + + + + + + M + +| 35 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7| | DAY ON TEST | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3| | | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + M + + M M + M + + + + M + + + + + M M M| 32 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + M + M + + + M + + + M + + +| 32 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + + + + M + + + + + + + + + M + + +| 47 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + M M + + + + + + M + + M + + + + + + + M + M M| 34 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Thymus | + + + M + + M + M M + + + + + + M + + + + + + + +| 34 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7| | DAY ON TEST | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3| | | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X | 8 | Alveolar/Bronchiolar Carcinoma | X| 4 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X X X | 8 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 2 | Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Ureter | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 3 | Lymphoma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7| DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3| | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + + + M A + + + + A + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + A + + + + + + + + + + +| Hemangioma | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + A + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + A + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + A + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatoblastoma | X X | Hepatocellular Carcinoma | X X X X X X X X X X| Hepatocellular Carcinoma, Multiple | X X X X X X X | Hepatocellular Adenoma | X X X X X X| Hepatocellular Adenoma, Multiple | X | Hepatocholangiocarcinoma | | Lymphoma Malignant | | Sarcoma | | __________________________________________________________________________| Mesentery | + + + + | Hemangiosarcoma | X X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Sarcoma, Metastatic, Liver | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Sarcoma, Metastatic, Liver | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + M + + M + + + + + M + I + + + + + + M + + +| _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7| DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3| | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Preputial Gland | + + + + + + M + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + A + + + + + + + + + + +| Sarcoma, Metastatic, Liver | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | | Lymphoma Malignant | | Iliac, Lymphoma Malignant | | Renal, Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Bronchial | + + + M M + + M M M M M + + + + + M + M + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + M + + + M + M + + M M M + + + + + + + M M + + +| Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + M M + M + + + + + + + + + + + M I + + M| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant | | Sarcoma, Metastatic, Liver | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | | __________________________________________________________________________| Thymus | M + + + + M + + + + + + + + + M + M M M M I + M I| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7| DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3| | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Hemangiosarcoma | | Subcutaneous Tissue, Hemangiosarcoma,| | Multiple | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + M + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X X| Alveolar/Bronchiolar Carcinoma | X X X| Alveolar/Bronchiolar Carcinoma, | | Multiple | X X X | Hemangiosarcoma, Metastatic, Skin | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X X X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Sarcoma, Metastatic, Liver | | Mediastinum, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +| Adenoma | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + +| Adenoma | X X X| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7| DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3| | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6| | | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + M + + + A + + M + + A + + A + + A + + + + +| 40 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + A + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + M A + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + + + + A + + A + + A + + + + +| 44 | Hemangioma | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + + + A + + A + + A + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + + + + A + + A + + A + + + + +| 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + A + + A + + + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X X X X | 5 | Hepatoblastoma | | 2 | Hepatocellular Carcinoma | X X X X X X X X | 18 | Hepatocellular Carcinoma, Multiple | X X X | 10 | Hepatocellular Adenoma | X X X X X | 11 | Hepatocellular Adenoma, Multiple | X X X X | 5 | Hepatocholangiocarcinoma | X | 1 | Lymphoma Malignant | X | 1 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Hemangiosarcoma | X | 3 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Sarcoma, Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Hemangiosarcoma | | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Sarcoma, Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6| | | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M + I + M + + M + + M M + + + + A M + M M M| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + A + + + + +| 47 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 | __________________________________________________________________________|____________| Prostate | + + + M + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Sarcoma, Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | + | 1 | Lymphoma Malignant | X | 1 | Iliac, Lymphoma Malignant | X | 1 | Renal, Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M M M M M M + + M M M M + M M + M M M M + + M| 23 | __________________________________________________________________________|____________| Lymph Node, Mandibular | I + + M M M M + M + M + + + + + + M M A M M M M +| 28 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + M + M + M + + + A + + + + M| 38 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6| | | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Sarcoma, Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Hemangiosarcoma | X | 2 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Thymus | + + M + + M M M + + + M M + + + M M + M M + + M M| 28 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Subcutaneous Tissue, Hemangiosarcoma | X X X | 3 | Subcutaneous Tissue, Hemangiosarcoma,| | | Multiple | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X | 12 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X X | 6 | Alveolar/Bronchiolar Carcinoma | X X X X X | 8 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 4 | Hemangiosarcoma, Metastatic, Skin | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X X | 10 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Sarcoma, Metastatic, Liver | X | 1 | Mediastinum, | | | Hepatocholangiocarcinoma, | | | Metastatic, Liver | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6| | | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + + | 5 | Adenoma | X X | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Lymphoma Malignant | X | 1 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6| DAY ON TEST | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6| | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + A + M + + + + + + + A M + M + + M + A +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + A +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + A M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + M + + + + + + + + + A + + + + + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | | Hemangiosarcoma | X X X | Hepatoblastoma | X X| Hepatocellular Carcinoma | X X X X X X X X X X X X | Hepatocellular Carcinoma, Multiple | X X X X X X X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X X X | Histiocytic Sarcoma | | __________________________________________________________________________| Mesentery | + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | X X X X X X X X| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +| Hemangiosarcoma, Metastatic, | | Mesentery | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +| Squamous Cell Papilloma | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Parathyroid Gland | M + + M + M M M + M M + M + + + M + M + M + + + +| __________________________________________________________________________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6| DAY ON TEST | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6| | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, | | Mesentery | X| Leiomyoma | X | Leiomyosarcoma | X | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, | | Mesentery | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | + + M M M + + M + M + + M + + + + + + + M + M + I| Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node, Mandibular | + + M M + M + + M + + + + + M M M M M M M M + M M| Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + M M| Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M M + + + M M + + M M + + M + + + + M +| Lymphoma Malignant | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | | __________________________________________________________________________| Thymus | + + + M M M M M + + M + + + M I + + + + M M + + I| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M + M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | | Subcutaneous Tissue, Sarcoma, | | Multiple | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6| DAY ON TEST | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6| | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X X | Alveolar/Bronchiolar Carcinoma | X X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X X X | Hepatoblastoma, Metastatic, Liver | X| Hepatocellular Carcinoma, Metastatic,| | Liver | X X X X | Bronchiole, Adenoma | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + + | Adenoma | X X | Carcinoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, | | Mesentery | X X | Histiocytic Sarcoma | | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7| | | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + A + + + M + M + + + A + + M + + + + + + + + +| 37 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | A M + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + A + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | A + A + + + + + + + + + A + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | A + A + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | X | 1 | Hemangiosarcoma | X X X | 6 | Hepatoblastoma | X | 3 | Hepatocellular Carcinoma | X X X X X X | 18 | Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X | 19 | Hepatocellular Adenoma | X X X X X X | 12 | Hepatocellular Adenoma, Multiple | X X X | 7 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + +| 16 | Hemangioma | | 1 | Hemangiosarcoma | X X X X X | 13 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Papilloma | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + M M + M M + M M + + + M + + + + + + + + +| 31 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7| | | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + + + + M + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | Leiomyoma | | 1 | Leiomyosarcoma | | 1 | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + M I + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Prostate | + + + M + + + + + + + + + + + + + + + + + + + + M| 48 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 2 | __________________________________________________________________________|____________| Lymph Node | +| 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + + + M M M M + + M + + + + + + + M + + +| 33 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + M + M + + + + M + + M + M + + + M + + + + M M| 27 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + I + + + + + +| 46 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + M M + + + + + + M + M + + + + + + + + + +| 37 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 2 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Thymus | M M M + + + M M + + M M + M + M + M + M M M + M +| 25 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7| | | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | X | 1 | Subcutaneous Tissue, Sarcoma, | | | Multiple | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X X | 15 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X X X X | 7 | Alveolar/Bronchiolar Carcinoma | X X X X X X X X| 13 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X X X X X | 10 | Hepatoblastoma, Metastatic, Liver | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 5 | Bronchiole, Adenoma | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + + + + + | 11 | Adenoma | X X X X X X | 8 | Carcinoma | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7| | | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma, Metastatic, | | | Mesentery | X X | 4 | Histiocytic Sarcoma | X | 1 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + M + + + + + + + + + I + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6| DAY ON TEST | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5| | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + M + M M + + M I + + + + + + + M + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + M + + + + + M| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Hemangiosarcoma | X X X X X X | Hepatoblastoma | X | Hepatocellular Carcinoma | X X X X X X X X| Hepatocellular Carcinoma, Multiple | X X X X X X X X | Hepatocellular Adenoma | X X X X X| Hepatocellular Adenoma, Multiple | X X X X X | Hepatocholangiocarcinoma | X | __________________________________________________________________________| Mesentery | + + + + + | Hemangioma | | Hemangiosarcoma | X X X | __________________________________________________________________________| Oral Mucosa | + | Gingival, Squamous Cell Carcinoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6| DAY ON TEST | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5| | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M M M M I M M + + M M + + M + M + + + + + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + + | Pancreatic, Lymphoma Malignant | | Renal, Hemangiosarcoma | X | Renal, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + M M M + M M M + M + + + + M M + M M + M| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X X | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M M + + M + + + M + M + M M M + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + M + + + +| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + M I + + M + + + + + + M + + + M + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6| DAY ON TEST | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5| | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | | __________________________________________________________________________| Thymus | + M + I + M M + + + M + + + M + M M M + + + + M +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Skeletal Muscle | + | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X X X X | Alveolar/Bronchiolar Carcinoma | X X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X X X X X X| Hemangiosarcoma, Metastatic, | | Mesentery | | Hepatoblastoma, Metastatic, Liver | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Mediastinum, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | X | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 _____________________________________________________________________________________________________________________ | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6| DAY ON TEST | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5| | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Respiratory Epithelium, Adenoma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + M M + + + + + | Adenoma | X X X X | Carcinoma | X | Bilateral, Adenoma | X | __________________________________________________________________________| Zymbal's Gland | M M M | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Hemangiosarcoma | | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X | Renal Tubule, Adenoma | X| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6| | DAY ON TEST | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5| | | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + M + M A + + + + + + + + + + +| 40 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A A + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Hemangiosarcoma | X X| 8 | Hepatoblastoma | | 1 | Hepatocellular Carcinoma | X X X X X X X X| 16 | Hepatocellular Carcinoma, Multiple | X X X X X X X X X | 17 | Hepatocellular Adenoma | X X X X X X | 11 | Hepatocellular Adenoma, Multiple | X X X X X | 10 | Hepatocholangiocarcinoma | | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + + | 11 | Hemangioma | X X | 2 | Hemangiosarcoma | X X X X | 7 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Gingival, Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | X X X X | 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6| | DAY ON TEST | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5| | | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + M + + + + + + + M + M + + + + + M + M + M| 30 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X| 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | + | 3 | Pancreatic, Lymphoma Malignant | X | 1 | Renal, Hemangiosarcoma | | 1 | Renal, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + M + + + + + + M + M + + + M M + + + M + M| 28 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X X | 4 | Hepatocholangiocarcinoma, Metastatic,| | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 05136-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC CHLOROPRENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:23:11 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6| | DAY ON TEST | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5| | | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Liver | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + M + M + + + + + + + + + M + + M + M + M +| 34 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + I + + + + M + M + + + + + + M M + + M + + + + M| 37 | Alveolar/Bronchiolar Carcinoma, |