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TDMS Study 05136-08 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 10/04/96       
EXPERIMENT: 05136 TEST: 08                                                                                     TIME: 09:59:07       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B       
PATHOLOGIST: R. MILLER                                                                                         CAS: 0000126-99-8    
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                                                             CORE STUDY                                                             
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 10/04/96       
EXPERIMENT: 05136 TEST: 08                                                                                     TIME: 09:59:07       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B       
PATHOLOGIST: R. MILLER                                                                                         CAS: 0000126-99-8    


                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 10/04/96       
EXPERIMENT: 05136 TEST: 08                                                                                     TIME: 09:59:07       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B       
PATHOLOGIST: R. MILLER                                                                                         CAS: 0000126-99-8    


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                         IN THE ANALYSIS OF THE STUDY OF 9-8CHLOROPRENE
              ====================================================================================================
                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Clitoral/Preputial Gland      Hemangiosarcoma
              Harderian Gland               Adenoma
                                            Carcinoma
                                            Carcinoma or Adenoma
              Kidney: Renal Tubule          Adenoma
              Liver                         Hemangiosarcoma
                                            Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatoblastoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Mesentery                     Hemangioma
                                            Hemangiosarcoma
              Nose                          Adenoma
              Skin                          Hemangiosarcoma
              Stomach, Forestomach          Squamous Cell Carcinoma or Papilloma Squamous
                                            Squamous Cell Papilloma
              All Organs                    Hemangiosarcoma
                                            Hemangiosarcoma or Hemangioma
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 10/04/96       
EXPERIMENT: 05136 TEST: 08                                                                                     TIME: 09:59:07       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B       
PATHOLOGIST: R. MILLER                                                                                         CAS: 0000126-99-8    


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                         IN THE ANALYSIS OF THE STUDY OF 9-8CHLOROPRENE
              ====================================================================================================
                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Harderian Gland               Adenoma
                                            Carcinoma or Adenoma
              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatoblastoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Mammary Gland                 Carcinoma
                                            Carcinoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Mesentery                     Hemangioma
                                            Hemangiosarcoma
                                            Sarcoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Skin                          Sarcoma
              Stomach, Forestomach          Squamous Cell Carcinoma or Papilloma Squamous
                                            Squamous Cell Papilloma
              Uterus                        Hemangioma
                                            Polyp Stromal
              Zymbal's Gland                Carcinoma
              All Organs                    Hemangioma
                                            Hemangiosarcoma
                                            Hemangiosarcoma or Hemangioma
                                            Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
                                             Cell Type
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE   1
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/49 (2%)    2/50 (4%)    1/50 (2%)  |  0/50 (0%)    1/49 (2%)    1/49 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         3.7%         8.5%         3.3%      |   0.0%         2.2%         3.6%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    1/27 (4%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      607          644       |   ---          482          551          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.301      P=0.500      P=0.159      P=0.458    |  P=0.615N     P=0.487      P=0.410        (e)      |
|INCIDENTAL TUMOR       |  P=0.506      P=0.500      P=0.313      P=0.587    |  P=0.336N     P=0.536      P=0.846        (e)      |
|LOGISTIC REGRESSION    |  P=0.430      P=0.500      P=0.239      P=0.533    |  P=0.457N     P=0.489      P=0.566        (e)      |
|COCHRAN-ARMITAGE       |  P=0.450                                           |  P=0.558N                                          |
|FISHER EXACT           |               P=0.495      P=0.247      P=0.500    |               P=0.495      P=0.495        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/47 (0%)    0/47 (0%)    2/50 (4%)  |  0/41 (0%)    0/40 (0%)    0/32 (0%)    0/35 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        10.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/25 (0%)    0/13 (0%)    1/13 (8%)  |  0/33 (0%)    0/14 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          603       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.021 *      (e)          (e)        P=0.149    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.037 *      (e)          (e)        P=0.201    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.041 *      (e)          (e)        P=0.227    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.046 *                                         |    (e)                                             |
|FISHER EXACT           |                 (e)          (e)        P=0.247    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE   2
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   8/50 (16%)  10/50 (20%) |  1/50 (2%)    3/50 (6%)    3/50 (6%)    8/50 (16%) |
|ADJUSTED (b)           |   5.8%        17.7%        36.8%        46.4%      |   2.9%        14.9%        12.0%        74.4%      |
|TERMINAL (d)           |  1/27 (4%)    4/27 (15%)   4/14 (29%)   4/13 (31%) |  1/35 (3%)    2/16 (13%)   0/1 (0%)     2/3 (67%)  |
|FIRST INCIDENCE (DAYS) |   596          701          596          589       |   734 (T)      621          524          467       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.213      P=0.009 **   P=0.001 ** |  P<0.001 **   P=0.120      P=0.048 *    P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.005 **   P=0.207      P=0.021 *    P=0.010 *  |  P=0.003 **   P=0.188      P=0.526      P=0.009 ** |
|LOGISTIC REGRESSION    |  P=0.004 **   P=0.205      P=0.035 *    P=0.007 ** |  P=0.001 **   P=0.225      P=0.293      P=0.007 ** |
|COCHRAN-ARMITAGE       |  P=0.013 *                                         |  P=0.006 **                                        |
|FISHER EXACT           |               P=0.218      P=0.046 *    P=0.014 *  |               P=0.309      P=0.309      P=0.015 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         8.7%        15.4%      |   2.2%         9.6%         0.0%        10.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    2/13 (15%) |  0/35 (0%)    1/16 (6%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          635          733 (T)   |   527          680          ---          652       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.030 *      (e)        P=0.154      P=0.097    |  P=0.349      P=0.367      P=0.566N     P=0.580    |
|INCIDENTAL TUMOR       |  P=0.084        (e)        P=0.313      P=0.097    |  P=0.638N     P=0.536      P=0.227N     P=0.598N   |
|LOGISTIC REGRESSION    |  P=0.058        (e)        P=0.226      P=0.097    |  P=0.639N     P=0.516      P=0.421N     P=0.736N   |
|COCHRAN-ARMITAGE       |  P=0.106                                           |  P=0.532N                                          |
|FISHER EXACT           |                 (e)        P=0.247      P=0.247    |               P=0.500      P=0.500N     P=0.753N   |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE   3
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)  10/50 (20%)  12/50 (24%) |  2/50 (4%)    5/50 (10%)   3/50 (6%)    9/50 (18%) |
|ADJUSTED (b)           |   5.8%        17.7%        42.3%        58.3%      |   5.0%        23.8%        12.0%        77.0%      |
|TERMINAL (d)           |  1/27 (4%)    4/27 (15%)   4/14 (29%)   6/13 (46%) |  1/35 (3%)    3/16 (19%)   0/1 (0%)     2/3 (67%)  |
|FIRST INCIDENCE (DAYS) |   596          701          596          589       |   527          621          524          467       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.213      P=0.002 **   P<0.001 ** |  P<0.001 **   P=0.065      P=0.157      P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.207      P=0.008 **   P=0.001 ** |  P=0.008 **   P=0.155      P=0.583N     P=0.045 *  |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.205      P=0.010 *    P=0.001 ** |  P=0.004 **   P=0.186      P=0.577      P=0.016 *  |
|COCHRAN-ARMITAGE       |  P=0.003 **                                        |  P=0.018 *                                         |
|FISHER EXACT           |               P=0.218      P=0.014 *    P=0.004 ** |               P=0.218      P=0.500      P=0.026 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/48 (0%)    0/49 (0%)    0/50 (0%)  |  0/49 (0%)    1/49 (2%)    2/48 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         3.4%        10.9%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          677          543          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.542      P=0.436      P=0.089        (e)      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.366N     P=0.718      P=0.602        (e)      |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.560N     P=0.493      P=0.268        (e)      |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.549N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500      P=0.242        (e)      |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE   4
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/49 (2%)    1/50 (2%)    3/50 (6%)  |  0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         3.6%         7.1%        13.8%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    1/14 (7%)    1/13 (8%)  |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          722          733 (T)      587       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.014 *    P=0.486      P=0.369      P=0.060    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.056      P=0.479      P=0.369      P=0.123    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.039 *    P=0.492      P=0.369      P=0.121    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.060                                           |    (e)                                             |
|FISHER EXACT           |               P=0.495      P=0.500      P=0.121    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   6/50 (12%)   8/49 (16%) |  1/50 (2%)    0/49 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.4%        16.3%        25.4%        30.3%      |   2.9%         0.0%         2.0%         0.0%      |
|TERMINAL (d)           |  2/27 (7%)    3/27 (11%)   2/14 (14%)   1/13 (8%)  |  1/35 (3%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   733 (T)      659          495          579       |   734 (T)      ---          216          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.003 **   P=0.219      P=0.039 *    P=0.008 ** |  P=0.676N     P=0.656N     P=0.525      P=0.941N   |
|INCIDENTAL TUMOR       |  P=0.044 *    P=0.205      P=0.111      P=0.052    |  P=0.520N     P=0.656N     P=0.652      P=0.941N   |
|LOGISTIC REGRESSION    |  P=0.031 *    P=0.201      P=0.108      P=0.036 *  |  P=0.319N     P=0.656N     P=0.666N     P=0.941N   |
|COCHRAN-ARMITAGE       |  P=0.045 *                                         |  P=0.439N                                          |
|FISHER EXACT           |               P=0.218      P=0.134      P=0.043 *  |               P=0.505N     P=0.753N     P=0.500N   |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE   5
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    3/50 (6%)    1/49 (2%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         5.7%        12.6%         3.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    1/27 (4%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          523          607          635       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.392      P=0.240      P=0.063      P=0.462    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.605N     P=0.314      P=0.189      P=0.587    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.591      P=0.254      P=0.116      P=0.540    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.544                                           |    (e)                                             |
|FISHER EXACT           |               P=0.247      P=0.121      P=0.495    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 22/50 (44%)  16/50 (32%)  19/50 (38%)  21/49 (43%) | 17/50 (34%)  19/49 (39%)  11/50 (22%)  16/50 (32%) |
|ADJUSTED (b)           |  64.4%        47.9%        72.3%        67.7%      |  47.0%        69.1%       100.0%        85.1%      |
|TERMINAL (d)           | 15/27 (56%)  11/27 (41%)   8/14 (57%)   6/13 (46%) | 16/35 (46%)   9/16 (56%)   1/1 (100%)   1/3 (33%)  |
|FIRST INCIDENCE (DAYS) |   635          439          439          392       |   637          523          505          383       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.006 **   P=0.175N     P=0.090      P=0.044 *  |  P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.189      P=0.159N     P=0.523      P=0.420    |  P=0.041 *    P=0.101      P=0.071      P=0.037 *  |
|LOGISTIC REGRESSION    |  P=0.183      P=0.156N     P=0.419      P=0.381    |  P=0.070      P=0.157      P=0.064      P=0.141    |
|COCHRAN-ARMITAGE       |  P=0.397                                           |  P=0.359N                                          |
|FISHER EXACT           |               P=0.151N     P=0.342N     P=0.535N   |               P=0.388      P=0.133N     P=0.500N   |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE   6
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 24/50 (48%)  28/50 (56%)  37/50 (74%)  33/49 (67%) |  4/50 (8%)   11/49 (22%)  14/50 (28%)  19/50 (38%) |
|ADJUSTED (b)           |  50.8%        63.2%        91.5%        87.2%      |  10.3%        41.8%       100.0%        91.5%      |
|TERMINAL (d)           |  6/27 (22%)  12/27 (44%)  11/14 (79%)   9/13 (69%) |  2/35 (6%)    4/16 (25%)   1/1 (100%)   2/3 (67%)  |
|FIRST INCIDENCE (DAYS) |   452          523          382          392       |   493          440          503          524       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.301      P<0.001 **   P=0.003 ** |  P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.139      P=0.268      P=0.049 *    P=0.201    |  P=0.001 **   P=0.056      P=0.070      P=0.008 ** |
|LOGISTIC REGRESSION    |  P=0.131      P=0.295      P=0.047 *    P=0.189    |  P<0.001 **   P=0.040 *    P=0.002 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.033 *                                         |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.274      P=0.007 **   P=0.040 *  |               P=0.041 *    P=0.009 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 24/50 (48%)  29/50 (58%)  39/50 (78%)  34/49 (69%) |  4/50 (8%)   11/49 (22%)  14/50 (28%)  19/50 (38%) |
|ADJUSTED (b)           |  50.8%        65.7%        92.1%        87.6%      |  10.3%        41.8%       100.0%        91.5%      |
|TERMINAL (d)           |  6/27 (22%)  13/27 (48%)  11/14 (79%)   9/13 (69%) |  2/35 (6%)    4/16 (25%)   1/1 (100%)   2/3 (67%)  |
|FIRST INCIDENCE (DAYS) |   452          523          382          392       |   493          440          503          524       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.253      P<0.001 **   P=0.002 ** |  P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.110      P=0.202      P=0.019 *    P=0.154    |  P=0.001 **   P=0.056      P=0.070      P=0.008 ** |
|LOGISTIC REGRESSION    |  P=0.099      P=0.221      P=0.018 *    P=0.141    |  P<0.001 **   P=0.040 *    P=0.002 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.022 *                                         |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.212      P=0.002 **   P=0.025 *  |               P=0.041 *    P=0.009 **   P<0.001 ** |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE   7
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 43/50 (86%)  37/50 (74%)  42/50 (84%)  41/49 (84%) | 20/50 (40%)  26/49 (53%)  20/50 (40%)  30/50 (60%) |
|ADJUSTED (b)           |  87.7%        81.5%        97.5%        94.6%      |  52.2%        81.8%       100.0%       100.0%      |
|TERMINAL (d)           | 21/27 (78%)  19/27 (70%)  13/14 (93%)  11/13 (85%) | 17/35 (49%)  11/16 (69%)   1/1 (100%)   3/3 (100%) |
|FIRST INCIDENCE (DAYS) |   452          439          382          392       |   493          440          503          383       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.002 **   P=0.272N     P=0.014 *    P=0.015 *  |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.521      P=0.088N     P=0.442N     P=0.361N   |  P<0.001 **   P=0.030 *    P=0.039 *    P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.530      P=0.087N     P=0.463N     P=0.402N   |  P<0.001 **   P=0.051      P=0.011 *    P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.432                                           |  P=0.054                                           |
|FISHER EXACT           |               P=0.105N     P=0.500N     P=0.483N   |               P=0.135      P=0.581N     P=0.036 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 43/50 (86%)  38/50 (76%)  43/50 (86%)  42/49 (86%) | 20/50 (40%)  26/49 (53%)  20/50 (40%)  30/50 (60%) |
|ADJUSTED (b)           |  87.7%        83.8%        97.6%        94.8%      |  52.2%        81.8%       100.0%       100.0%      |
|TERMINAL (d)           | 21/27 (78%)  20/27 (74%)  13/14 (93%)  11/13 (85%) | 17/35 (49%)  11/16 (69%)   1/1 (100%)   3/3 (100%) |
|FIRST INCIDENCE (DAYS) |   452          439          382          392       |   493          440          503          383       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.001 **   P=0.320N     P=0.010 **   P=0.011 *  |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.447      P=0.132N     P=0.535N     P=0.447N   |  P<0.001 **   P=0.030 *    P=0.039 *    P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.441      P=0.132N     P=0.580N     P=0.503N   |  P<0.001 **   P=0.051      P=0.011 *    P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.353                                           |  P=0.054                                           |
|FISHER EXACT           |               P=0.154N     P=0.613N     P=0.597N   |               P=0.135      P=0.581N     P=0.036 *  |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE   8
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/50 (16%)  18/50 (36%)  22/50 (44%)  28/50 (56%) |  2/50 (4%)   16/49 (33%)  29/50 (58%)  26/50 (52%) |
|ADJUSTED (b)           |  23.8%        54.8%        68.3%        84.7%      |   5.7%        57.9%       100.0%       100.0%      |
|TERMINAL (d)           |  4/27 (15%)  13/27 (48%)   6/14 (43%)   9/13 (69%) |  2/35 (6%)    6/16 (38%)   1/1 (100%)   3/3 (100%) |
|FIRST INCIDENCE (DAYS) |   635          530          382          523       |   734 (T)      447          346          453       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.023 *    P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.020 *    P=0.005 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.016 *    P=0.002 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.020 *    P=0.002 **   P<0.001 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/50 (12%)  12/50 (24%)  23/50 (46%)  28/50 (56%) |  2/50 (4%)   14/49 (29%)  16/50 (32%)  28/50 (56%) |
|ADJUSTED (b)           |  21.3%        37.9%        76.7%        85.1%      |   5.5%        51.9%       100.0%        95.4%      |
|TERMINAL (d)           |  5/27 (19%)   8/27 (30%)   8/14 (57%)   9/13 (69%) |  1/35 (3%)    6/16 (38%)   1/1 (100%)   2/3 (67%)  |
|FIRST INCIDENCE (DAYS) |   729          638          567          524       |   706          447          524          324       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.096      P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.083      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.001 **   P=0.004 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.075      P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.096      P<0.001 **   P<0.001 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE   9
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/50 (26%)  28/50 (56%)  36/50 (72%)  43/50 (86%) |  4/50 (8%)   28/49 (57%)  34/50 (68%)  42/50 (84%) |
|ADJUSTED (b)           |  39.2%        79.4%        89.0%       100.0%      |  11.0%        83.5%       100.0%       100.0%      |
|TERMINAL (d)           |  8/27 (30%)  20/27 (74%)  10/14 (71%)  13/13 (100%)|  3/35 (9%)   11/16 (69%)   1/1 (100%)   3/3 (100%) |
|FIRST INCIDENCE (DAYS) |   635          530          382          523       |   706          447          346          324       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.002 **   P<0.001 **   P<0.001 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         5.3%         0.0%      |   0.0%        10.0%         2.0%         3.3%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    1/16 (6%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          701          ---       |   ---          691          216          576       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.711        (e)        P=0.402        (e)      |  P=0.225      P=0.121      P=0.504      P=0.424    |
|INCIDENTAL TUMOR       |  P=0.734N       (e)        P=0.581        (e)      |  P=0.595      P=0.233      P=0.638      P=0.864    |
|LOGISTIC REGRESSION    |  P=0.754        (e)        P=0.451        (e)      |  P=0.651N     P=0.172      P=0.403      P=0.550    |
|COCHRAN-ARMITAGE       |  P=0.778                                           |  P=0.574                                           |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.247      P=0.500      P=0.500    |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  10
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoacanthoma                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    1/50 (2%)    3/50 (6%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         2.1%         7.7%         7.9%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          440          425          582       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.147      P=0.492      P=0.091      P=0.128    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.551      P=0.536      P=0.440      P=0.696    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.355      P=0.496      P=0.205      P=0.252    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.216                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500      P=0.121      P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  3/50 (6%)    4/50 (8%)    7/50 (14%)  12/50 (24%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   7.4%        13.6%        35.1%        56.4%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  1/35 (3%)    1/16 (6%)    0/1 (0%)     1/3 (33%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   527          447          394          336       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P<0.001 **   P=0.322      P=0.003 **   P<0.001 ** |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.042 *    P=0.564      P=0.634N     P=0.220    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.008 **   P=0.553      P=0.207      P=0.036 *  |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.003 **                                        |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500      P=0.159      P=0.011 *  |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  11
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  3/50 (6%)    5/50 (10%)   8/50 (16%)  12/50 (24%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   7.4%        18.4%        37.0%        56.4%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  1/35 (3%)    1/16 (6%)    0/1 (0%)     1/3 (33%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   527          447          394          336       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P<0.001 **   P=0.179      P=0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.071      P=0.470      P=0.637      P=0.220    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.013 *    P=0.397      P=0.152      P=0.036 *  |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.005 **                                        |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.357      P=0.100      P=0.011 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  3/50 (6%)    5/50 (10%)   8/50 (16%)  12/50 (24%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   7.4%        18.4%        37.0%        56.4%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  1/35 (3%)    1/16 (6%)    0/1 (0%)     1/3 (33%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   527          447          394          336       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P<0.001 **   P=0.179      P=0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.071      P=0.470      P=0.637      P=0.220    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.013 *    P=0.397      P=0.152      P=0.036 *  |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.005 **                                        |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.357      P=0.100      P=0.011 *  |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  12
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.8%        12.6%      |   0.0%         0.0%       100.0%        33.3%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    1/13 (8%)  |  0/35 (0%)    0/16 (0%)    1/1 (100%)   1/3 (33%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          607          677       |   ---          ---          607          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.032 *      (e)        P=0.465      P=0.112    |  P=0.023 *      (e)        P=0.010 *    P=0.059    |
|INCIDENTAL TUMOR       |  P=0.085        (e)        P=0.548      P=0.198    |  P=0.071        (e)        P=0.056      P=0.059    |
|LOGISTIC REGRESSION    |  P=0.068        (e)        P=0.579      P=0.154    |  P=0.078        (e)        P=0.072      P=0.059    |
|COCHRAN-ARMITAGE       |  P=0.077                                           |  P=0.307                                           |
|FISHER EXACT           |                 (e)        P=0.500      P=0.247    |                 (e)        P=0.247      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)   13/50 (26%)   7/50 (14%) |  0/50 (0%)    4/50 (8%)   13/50 (26%)   4/50 (8%)  |
|ADJUSTED (b)           |   0.0%        10.1%        51.1%        40.3%      |   0.0%        18.6%        59.3%        15.8%      |
|TERMINAL (d)           |  0/27 (0%)    2/27 (7%)    4/14 (29%)   4/13 (31%) |  0/35 (0%)    1/16 (6%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          680          502          628       |   ---          691          389          523       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.123      P<0.001 **   P<0.001 ** |  P=0.008 **   P=0.015 *    P<0.001 **   P=0.016 *  |
|INCIDENTAL TUMOR       |  P=0.015 *    P=0.116      P<0.001 **   P=0.003 ** |  P=0.458N     P=0.117      P=0.058      P=0.414    |
|LOGISTIC REGRESSION    |  P=0.006 **   P=0.114      P<0.001 **   P=0.001 ** |  P=0.525N     P=0.032 *    P<0.001 **   P=0.072    |
|COCHRAN-ARMITAGE       |  P=0.023 *                                         |  P=0.206                                           |
|FISHER EXACT           |               P=0.121      P<0.001 **   P=0.006 ** |               P=0.059      P<0.001 **   P=0.059    |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  13
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    4/50 (8%)    8/50 (16%)   3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%        16.3%        46.5%        12.6%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    1/16 (6%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          523          463          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.018 *    P=0.023 *    P<0.001 **   P=0.041 *  |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.519N     P=0.094      P=0.120      P=0.485    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.308      P=0.060      P=0.004 **   P=0.157    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.313                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.059      P=0.003 **   P=0.121    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/48 (0%)    0/50 (0%)    2/50 (4%)  |  0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        13.1%      |   0.0%         0.0%        12.5%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    1/13 (8%)  |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          680       |   ---          ---          656          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.010 **     (e)          (e)        P=0.103    |  P=0.623        (e)        P=0.181        (e)      |
|INCIDENTAL TUMOR       |  P=0.032 *      (e)          (e)        P=0.198    |  P=0.785        (e)        P=0.581        (e)      |
|LOGISTIC REGRESSION    |  P=0.021 *      (e)          (e)        P=0.150    |  P=0.759        (e)        P=0.416        (e)      |
|COCHRAN-ARMITAGE       |  P=0.044 *                                         |  P=0.778                                           |
|FISHER EXACT           |                 (e)          (e)        P=0.247    |                 (e)        P=0.495        (e)      |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  14
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    0/47 (0%)    0/47 (0%)    0/48 (0%)  |  4/49 (8%)    6/48 (13%)   4/48 (8%)    4/50 (8%)  |
|ADJUSTED (b)           |   2.8%         0.0%         0.0%         0.0%      |  11.1%        30.5%        31.6%        34.7%      |
|TERMINAL (d)           |  0/26 (0%)    0/26 (0%)    0/12 (0%)    0/13 (0%)  |  3/35 (9%)    3/15 (20%)   0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   666          ---          ---          ---       |   729          636          620          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.490N     P=0.506N     P=0.557N     P=0.617N   |  P=0.006 **   P=0.056      P=0.002 **   P=0.027 *  |
|INCIDENTAL TUMOR       |  P=0.352N     P=0.521N     P=0.433N     P=0.433N   |  P=0.437      P=0.282      P=0.505      P=0.504    |
|LOGISTIC REGRESSION    |  P=0.406N     P=0.508N     P=0.510N     P=0.503N   |  P=0.299      P=0.146      P=0.124      P=0.525    |
|COCHRAN-ARMITAGE       |  P=0.407N                                          |  P=0.439N                                          |
|FISHER EXACT           |               P=0.510N     P=0.510N     P=0.505N   |               P=0.357      P=0.631      P=0.631N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    4/50 (8%)    1/50 (2%)    7/50 (14%) |  2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   3.7%        12.3%         3.4%        31.5%      |   5.0%         2.2%         5.8%         3.0%      |
|TERMINAL (d)           |  1/27 (4%)    1/27 (4%)    0/14 (0%)    2/13 (15%) |  1/35 (3%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   733 (T)      659          649          454       |   541          482          440          538       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.002 **   P=0.183      P=0.659      P=0.005 ** |  P=0.599      P=0.605N     P=0.401      P=0.712    |
|INCIDENTAL TUMOR       |  P=0.029 *    P=0.158      P=0.741      P=0.035 *  |  P=0.287N     P=0.547N     P=0.509N     P=0.468N   |
|LOGISTIC REGRESSION    |  P=0.017 *    P=0.172      P=0.731      P=0.033 *  |  P=0.340N     P=0.458N     P=0.584N     P=0.457N   |
|COCHRAN-ARMITAGE       |  P=0.022 *                                         |  P=0.465N                                          |
|FISHER EXACT           |               P=0.181      P=0.753N     P=0.030 *  |               P=0.500N     P=0.691N     P=0.500N   |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  15
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)   11/50 (22%)  11/50 (22%)  18/50 (36%) |
|ADJUSTED (b)           |   0.0%         0.0%         2.8%         0.0%      |   0.0%        35.3%       100.0%        69.6%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    2/16 (13%)   1/1 (100%)   0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          607          ---       |   ---          285          524          462       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.763        (e)        P=0.465        (e)      |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.722N       (e)        P=0.548        (e)      |  P=0.004 **   P=0.008 **   P=0.007 **   P=0.009 ** |
|LOGISTIC REGRESSION    |  P=0.759N       (e)        P=0.579        (e)      |  P<0.001 **   P=0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.778                                           |  P<0.001 **                                        |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/49 (4%)    2/50 (4%)    1/50 (2%)  |  1/50 (2%)    1/49 (2%)    1/49 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         7.4%         8.5%         2.6%      |   2.9%         2.2%         3.6%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    2/27 (7%)    0/14 (0%)    0/13 (0%)  |  1/35 (3%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      607          603       |   734 (T)      482          551          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.382      P=0.238      P=0.159      P=0.471    |  P=0.532N     P=0.669      P=0.436      P=0.941N   |
|INCIDENTAL TUMOR       |  P=0.564      P=0.238      P=0.313      P=0.587    |  P=0.281N     P=0.701      P=0.840      P=0.941N   |
|LOGISTIC REGRESSION    |  P=0.536      P=0.238      P=0.239      P=0.583    |  P=0.271N     P=0.750N     P=0.760      P=0.941N   |
|COCHRAN-ARMITAGE       |  P=0.564                                           |  P=0.316N                                          |
|FISHER EXACT           |               P=0.242      P=0.247      P=0.500    |               P=0.747      P=0.747      P=0.500N   |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  16
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    2/50 (4%)    5/50 (10%) |  1/50 (2%)    0/50 (0%)    0/50 (0%)    4/50 (8%)  |
|ADJUSTED (b)           |   3.7%         0.0%        14.3%        15.3%      |   2.9%         0.0%         0.0%        18.8%      |
|TERMINAL (d)           |  1/27 (4%)    0/27 (0%)    2/14 (14%)   0/13 (0%)  |  1/35 (3%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          733 (T)      587       |   734 (T)      ---          ---          576       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.002 **   P=0.500N     P=0.276      P=0.052    |  P<0.001 **   P=0.656N     P=0.998N     P=0.015 *  |
|INCIDENTAL TUMOR       |  P=0.013 *    P=0.500N     P=0.276      P=0.158    |  P=0.037 *    P=0.656N     P=0.998N     P=0.533    |
|LOGISTIC REGRESSION    |  P=0.010 *    P=0.500N     P=0.276      P=0.132    |  P=0.007 **   P=0.656N     P=0.998N     P=0.120    |
|COCHRAN-ARMITAGE       |  P=0.012 *                                         |  P=0.018 *                                         |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.102    |               P=0.500N     P=0.500N     P=0.181    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    2/50 (4%)    4/50 (8%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    4/50 (8%)  |
|ADJUSTED (b)           |   3.7%         0.0%        14.3%        12.7%      |   0.0%         0.0%         0.0%        18.8%      |
|TERMINAL (d)           |  1/27 (4%)    0/27 (0%)    2/14 (14%)   0/13 (0%)  |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          733 (T)      587       |   ---          ---          ---          576       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.009 **   P=0.500N     P=0.276      P=0.099    |  P<0.001 **     (e)          (e)        P=0.010 ** |
|INCIDENTAL TUMOR       |  P=0.032 *    P=0.500N     P=0.276      P=0.238    |  P=0.021 *      (e)          (e)        P=0.486    |
|LOGISTIC REGRESSION    |  P=0.030 *    P=0.500N     P=0.276      P=0.216    |  P=0.001 **     (e)          (e)        P=0.053    |
|COCHRAN-ARMITAGE       |  P=0.037 *                                         |  P=0.002 **                                        |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.181    |                 (e)          (e)        P=0.059    |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  17
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    2/49 (4%)    0/49 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%        11.5%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    1/16 (6%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          719          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.729      P=0.099        (e)          (e)      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.617N     P=0.233        (e)          (e)      |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.780      P=0.131        (e)          (e)      |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.381N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.242        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/49 (2%)    1/50 (2%)    1/50 (2%)  |  1/50 (2%)    3/49 (6%)    1/49 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.4%         3.7%         3.7%         7.7%      |   2.9%        14.3%        12.5%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    1/27 (4%)    0/14 (0%)    1/13 (8%)  |  1/35 (3%)    1/16 (6%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   729          733 (T)      666          733 (T)   |   734 (T)      673          656          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.436      P=0.752      P=0.645      P=0.581    |  P=0.566      P=0.121      P=0.222      P=0.941N   |
|INCIDENTAL TUMOR       |  P=0.620      P=0.749      P=0.671N     P=0.735    |  P=0.391N     P=0.311      P=0.598      P=0.941N   |
|LOGISTIC REGRESSION    |  P=0.515      P=0.753      P=0.720      P=0.582    |  P=0.535N     P=0.197      P=0.543      P=0.941N   |
|COCHRAN-ARMITAGE       |  P=0.653N                                          |  P=0.179N                                          |
|FISHER EXACT           |               P=0.747      P=0.753N     P=0.753N   |               P=0.301      P=0.747      P=0.500N   |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  18
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |                                                    |   0.0%         0.0%         0.0%         9.3%      |
|TERMINAL (d)           |                                                    |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          ---          ---          624       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.014 *      (e)          (e)        P=0.102    |
|INCIDENTAL TUMOR       |                                                    |  P=0.133        (e)          (e)        P=0.696    |
|LOGISTIC REGRESSION    |                                                    |  P=0.027 *      (e)          (e)        P=0.206    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.043 *                                         |
|FISHER EXACT           |                                                    |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         0.0%         7.6%         0.0%      |
|TERMINAL (d)           |                                                    |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          ---          515          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.626        (e)        P=0.135        (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.520N       (e)        P=0.616        (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.679N       (e)        P=0.303        (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.700                                           |
|FISHER EXACT           |                                                    |                 (e)        P=0.247        (e)      |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  19
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/50 (4%)    4/50 (8%)    2/50 (4%)    3/50 (6%)  |
|ADJUSTED (b)           |                                                    |   5.7%        17.7%         6.7%        23.2%      |
|TERMINAL (d)           |                                                    |  2/35 (6%)    2/16 (13%)   0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |                                                    |   734 (T)      551          537          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.037 *    P=0.118      P=0.187      P=0.037 *  |
|INCIDENTAL TUMOR       |                                                    |  P=0.349      P=0.243      P=0.643      P=0.323    |
|LOGISTIC REGRESSION    |                                                    |  P=0.438      P=0.270      P=0.668      P=0.417    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.549                                           |
|FISHER EXACT           |                                                    |               P=0.339      P=0.691N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%        10.8%      |
|TERMINAL (d)           |  0/27 (0%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          ---          565       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.004 **     (e)          (e)        P=0.054    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.053        (e)          (e)        P=0.577    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.009 **     (e)          (e)        P=0.137    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.010 **                                        |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)          (e)        P=0.121    |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  20
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    2/50 (4%)    3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         3.7%         7.2%        12.6%      |   0.0%         0.0%       100.0%        39.5%      |
|TERMINAL (d)           |  0/27 (0%)    1/27 (4%)    0/14 (0%)    1/13 (8%)  |  0/35 (0%)    0/16 (0%)    1/1 (100%)   1/3 (33%)  |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      607          677       |   ---          ---          607          624       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.073      P=0.500      P=0.185      P=0.112    |  P<0.001 **     (e)        P=0.010 *    P=0.007 ** |
|INCIDENTAL TUMOR       |  P=0.194      P=0.500      P=0.313      P=0.198    |  P=0.012 *      (e)        P=0.056      P=0.102    |
|LOGISTIC REGRESSION    |  P=0.152      P=0.500      P=0.256      P=0.154    |  P=0.004 **     (e)        P=0.072      P=0.037 *  |
|COCHRAN-ARMITAGE       |  P=0.199                                           |  P=0.032 *                                         |
|FISHER EXACT           |               P=0.500      P=0.247      P=0.247    |                 (e)        P=0.247      P=0.121    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)   13/50 (26%)  22/50 (44%)  19/50 (38%) |  4/50 (8%)    6/50 (12%)  17/50 (34%)   5/50 (10%) |
|ADJUSTED (b)           |  11.1%        38.6%        69.8%        68.0%      |  10.6%        25.7%       100.0%        18.3%      |
|TERMINAL (d)           |  3/27 (11%)   7/27 (26%)   6/14 (43%)   6/13 (46%) |  3/35 (9%)    2/16 (13%)   1/1 (100%)   0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   733 (T)      659          495          454       |   541          482          216          523       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 ** |  P=0.017 *    P=0.104      P<0.001 **   P=0.061    |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 ** |  P=0.301N     P=0.310      P=0.029 *    P=0.669N   |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 ** |  P=0.493N     P=0.330      P=0.009 **   P=0.486    |
|COCHRAN-ARMITAGE       |  P=0.001 **                                        |  P=0.504                                           |
|FISHER EXACT           |               P=0.006 **   P<0.001 **   P<0.001 ** |               P=0.370      P=0.001 **   P=0.500    |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  21
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)   14/50 (28%)  23/50 (46%)  21/50 (42%) |  4/50 (8%)    6/50 (12%)  18/50 (36%)   8/50 (16%) |
|ADJUSTED (b)           |  11.1%        41.7%        70.7%        74.1%      |  10.6%        25.7%       100.0%        50.8%      |
|TERMINAL (d)           |  3/27 (11%)   8/27 (30%)   6/14 (43%)   7/13 (54%) |  3/35 (9%)    2/16 (13%)   1/1 (100%)   1/3 (33%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      659          495          454       |   541          482          216          523       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.104      P<0.001 **   P=0.002 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 ** |  P=0.482      P=0.310      P=0.024 *    P=0.288    |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 ** |  P=0.248      P=0.330      P=0.005 **   P=0.110    |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P=0.189                                           |
|FISHER EXACT           |               P=0.003 **   P<0.001 **   P<0.001 ** |               P=0.370      P<0.001 **   P=0.178    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)  |  1/50 (2%)    2/50 (4%)    3/50 (6%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.5%         0.0%         6.4%         4.0%      |   2.4%         6.9%         6.7%         0.0%      |
|TERMINAL (d)           |  1/27 (4%)    0/27 (0%)    0/14 (0%)    0/13 (0%)  |  0/35 (0%)    0/16 (0%)    0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   603          ---          607          656       |   637          551          378          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.556N     P=0.130N     P=0.640N     P=0.480N   |  P=0.508N     P=0.392      P=0.180      P=0.733N   |
|INCIDENTAL TUMOR       |  P=0.299N     P=0.136N     P=0.440N     P=0.255N   |  P=0.079N     P=0.633N     P=0.627N     P=0.136N   |
|LOGISTIC REGRESSION    |  P=0.370N     P=0.116N     P=0.463N     P=0.290N   |  P=0.169N     P=0.528      P=0.492      P=0.521N   |
|COCHRAN-ARMITAGE       |  P=0.397N                                          |  P=0.285N                                          |
|FISHER EXACT           |               P=0.121N     P=0.500N     P=0.309N   |               P=0.500      P=0.309      P=0.500N   |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  22
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    2/50 (4%)    4/50 (8%)  |  7/50 (14%)   7/50 (14%)   3/50 (6%)    1/50 (2%)  |
|ADJUSTED (b)           |   6.5%         7.4%        14.3%        15.6%      |  18.0%        26.9%        22.3%        10.0%      |
|TERMINAL (d)           |  1/27 (4%)    2/27 (7%)    2/14 (14%)   1/13 (8%)  |  5/35 (14%)   2/16 (13%)   0/1 (0%)     0/3 (0%)   |
|FIRST INCIDENCE (DAYS) |   680          733 (T)      733 (T)      603       |    35          548          539          652       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.057      P=0.694      P=0.469      P=0.166    |  P=0.539N     P=0.234      P=0.216      P=0.606N   |
|INCIDENTAL TUMOR       |  P=0.128      P=0.685      P=0.553      P=0.354    |  P=0.035N*    P=0.526N     P=0.438N     P=0.177N   |
|LOGISTIC REGRESSION    |  P=0.133      P=0.683      P=0.538      P=0.329    |  P=0.020N*    P=0.579N     P=0.103N     P=0.021N*  |
|COCHRAN-ARMITAGE       |  P=0.216                                           |  P=0.014N*                                         |
|FISHER EXACT           |               P=0.691N     P=0.691N     P=0.339    |               P=0.613N     P=0.159N     P=0.030N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 31/50 (62%)  31/50 (62%)  38/50 (76%)  43/50 (86%) | 22/50 (44%)  32/50 (64%)  38/50 (76%)  42/50 (84%) |
|ADJUSTED (b)           |  79.3%        78.8%        91.9%        97.5%      |  57.8%        87.7%       100.0%       100.0%      |
|TERMINAL (d)           | 19/27 (70%)  19/27 (70%)  11/14 (79%)  12/13 (92%) | 19/35 (54%)  12/16 (75%)   1/1 (100%)   3/3 (100%) |
|FIRST INCIDENCE (DAYS) |   596          439          382          392       |   637          447          346          383       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.540      P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.547      P=0.053      P<0.001 ** |  P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.532      P=0.026 *    P<0.001 ** |  P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.002 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.582N     P=0.097      P=0.006 ** |               P=0.035 *    P=0.001 **   P<0.001 ** |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  23
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 34/50 (68%)  40/50 (80%)  50/50 (100%) 47/50 (94%) | 20/50 (40%)  42/50 (84%)  49/50 (98%)  48/50 (96%) |
|ADJUSTED (b)           |  71.4%        83.2%       100.0%        97.9%      |  44.8%        89.3%       100.0%       100.0%      |
|TERMINAL (d)           | 14/27 (52%)  19/27 (70%)  14/14 (100%) 12/13 (92%) | 11/35 (31%)  11/16 (69%)   1/1 (100%)   3/3 (100%) |
|FIRST INCIDENCE (DAYS) |   452          523          382          392       |    35          285          216          324       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.223      P<0.001 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.004 **   P=0.111      P<0.001 **   P=0.011 *  |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.004 **   P=0.126      P<0.001 **   P=0.014 *  |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.127      P<0.001 **   P<0.001 ** |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 48/50 (96%)  48/50 (96%)  50/50 (100%) 50/50 (100%)| 34/50 (68%)  47/50 (94%)  50/50 (100%) 48/50 (96%) |
|ADJUSTED (b)           |  96.0%        97.9%       100.0%       100.0%      |  77.0%        97.9%       100.0%       100.0%      |
|TERMINAL (d)           | 25/27 (93%)  26/27 (96%)  14/14 (100%) 13/13 (100%)| 25/35 (71%)  15/16 (94%)   1/1 (100%)   3/3 (100%) |
|FIRST INCIDENCE (DAYS) |   452          439          382          392       |    35          285          216          324       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.518      P=0.002 **   P<0.001 ** |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.164      P=0.685N     P=0.391      P=0.409    |  P=0.004 **   P=0.001 **   P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.171      P=0.684N     P=0.391      P=0.409    |  P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.106                                           |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.691N     P=0.247      P=0.247    |               P<0.001 **   P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
         DATE: 10/04/96                     EXPERIMENT: 05136 TEST: 08                                                 PAGE  24
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
                                                                           
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.