TDMS Study 05136-08 Pathology Tables
NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 CORE STUDY Facility: Battelle Northwest Chemical CAS #: 0000126-99-8 Lock Date: 04/14/94 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + M + + + + + + + M + + + + + + + + M + +| Angiectasis | | Cyst | 4 | Inflammation, Suppurative | 1 2 | Necrosis | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | | Peyer's Patch, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Basophilic Focus | X X 4 X | Clear Cell Focus | | Degeneration, Fatty | 1 | Eosinophilic Focus | X X X X X X X X| Fibrosis | 2 | Hematopoietic Cell Proliferation | 1 | Necrosis | 2 1 | Bile Duct, Cyst | | Bile Duct, Hyperplasia | 2 | __________________________________________________________________________| Mesentery | + + + + + + | Angiectasis | | Fat, Necrosis | 3 2 3 3 | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Hyperplasia | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +| Atrophy | 1 | Hypertrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Mineralization | 2 | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Hyperplasia | 1 | Inflammation | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia | 1 | Hypertrophy | 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Parathyroid Gland | M M + + + + + + + M + + + + + M + M M M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 3 2 2 2 1 2 4 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 3 4 1 1 1 2 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + M + M M + M + + + + + + M + + + + + +| __________________________________________________________________________| Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 3 | Cyst | 4 2 1 2 2 2 2 3 1 3 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Hemorrhage | | Hydrometra | | Hyperplasia, Cystic | 4 2 3 2 | Inflammation, Suppurative | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Necrosis | | __________________________________________________________________________| Lymph Node | + | Iliac, Hyperplasia | 2 | Pancreatic, Hyperplasia | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + M + + + M M + + + + + + M + M M M M + +| Hyperplasia | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + M M + + + M M M + + + M + M M M + M + M + +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Angiectasis | 4 | Hematopoietic Cell Proliferation | | Hyperplasia | 3 2 4 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M M + + + M + + + + + M + M + + + + + M| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | 2 3 2 3 2 | Hyperplasia, Lymphoid | 2 2 3 2 2 2 2 | Infiltration Cellular, Mononuclear | | Cell | 2 | __________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + + + + M M + + + +| Angiectasis | 2 | Atrophy | | Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Subcutaneous Tissue, Inflammation, | | Suppurative | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 2 2 3 2 2 2 1 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Gliosis | 2 | Meninges, Inflammation, Chronic | 3 1 | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | | Alveolar Epithelium, Hyperplasia | 1 | Perivascular, Infiltration Cellular | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Olfactory Epithelium, Atrophy | 1 1 1 | Olfactory Epithelium, Degeneration, | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| | 5| 4| 1| 5| 5| 5| 3| 5| 5| 7| 5| 9| 5| 4| 5| 5| 4| 5| 4| 5| 5| 4| 4| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hyaline | | Olfactory Epithelium, Hyperplasia, | | Adenomatous | 1 1 | Olfactory Epithelium, Metaplasia | 1 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Inflammation, Chronic Active | | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Artery, Inflammation, Chronic | 3 | Renal Tubule, Mineralization | | __________________________________________________________________________| Ureter | | __________________________________________________________________________| Urethra | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 45 | Angiectasis | 2 | 1 2.0| Cyst | | 1 4.0| Inflammation, Suppurative | 1 | 3 1.3| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 2 | 1 2.0| Peyer's Patch, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 2 3.0| Basophilic Focus | | 4 4.0| Clear Cell Focus | 2 | 1 2.0| Degeneration, Fatty | | 1 1.0| Eosinophilic Focus | X X X X 4 | 13 4.0| Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | | 1 1.0| Necrosis | 1 1 | 4 1.3| Bile Duct, Cyst | 2 | 1 2.0| Bile Duct, Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Mesentery | + + + + | 10 | Angiectasis | 1 | 1 1.0| Fat, Necrosis | 3 2 3 | 7 2.7| __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 1 | 3 1.0| Hypertrophy | 1 1 | 2 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 | 2 1.0| Mineralization | | 1 2.0| Epithelium, Hyperplasia | 4 1 2 | 4 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | Hyperplasia | | 1 1.0| Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | | 1 1.0| Hypertrophy | | 2 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 3 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + M + M + + + + + + M + + M M + + + + M + M| 35 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Pars Distalis, Hyperplasia | 2 2 2 2 1 1 1 2 2 1 | 18 1.9| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 1 2 1 2| 12 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M + + I + + + + + M + + + + + + + + +| 41 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | Atrophy | 2 3 2 2 | 7 2.1| Cyst | 2 1 2 2 1 2 2 2 2 | 20 2.1| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 3 2.0| Hemorrhage | 2 | 1 2.0| Hydrometra | 3 2 2| 3 2.3| Hyperplasia, Cystic | 3 | 5 2.8| Inflammation, Suppurative | | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | 3 | 2 3.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node | + + + | 4 | Iliac, Hyperplasia | | 1 2.0| Pancreatic, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + + M + + + I + + M + M + + + + + + M M M +| 32 | Hyperplasia | 3 | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + I + + + + M + M + + + + + M + + M + + + M M +| 32 | Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Angiectasis | | 1 4.0| Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | 2 2 | 6 2.5| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M M M + M + + M + + + + + + M +| 38 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Hematopoietic Cell Proliferation | 3 2 4 2 2 3 2 2 | 13 2.5| Hyperplasia, Lymphoid | 2 2 | 9 2.1| Infiltration Cellular, Mononuclear | | | Cell | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + M + + + + + + + + + M + +| 44 | Angiectasis | | 1 2.0| Atrophy | 2 | 1 2.0| Hyperplasia, Lymphoid | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 3 | 1 3.0| Subcutaneous Tissue, Inflammation, | | | Suppurative | 3 2 | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 3 2 1 1 2 1 | 15 1.7| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Gliosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 7| 6| 7| 5| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 1| 0| 3| 3| 2| 3| 0| 7| 3| 4| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 5| 5| 4| 7| 4| 6| 7| 5| 1| 4| 5| 6| 5| 5| 5| 5| 5| 5| 4| 7| 4| 4| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Meninges, Inflammation, Chronic | 1 | 3 1.7| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | Degeneration | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1| 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia | | 1 1.0| Perivascular, Infiltration Cellular | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Olfactory Epithelium, Atrophy | 2 1 1 | 6 1.2| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 1| 3 1.0| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | | 2 1.0| Olfactory Epithelium, Metaplasia | | 2 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 1 1 1| 17 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | 3 | 1 3.0| Inflammation, Chronic Active | 1 | 1 1.0| Nephropathy | 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| 41 1.0| Artery, Inflammation, Chronic | | 1 3.0| Renal Tubule, Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Ureter | + | 1 | __________________________________________________________________________|____________| Urethra | + | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6| DAY ON TEST | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3| | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Gallbladder | + + A M + + + + + + + + A + + + + + + + + + + A +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + A +| Inflammation, Suppurative | | __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + A + + + + + + + + + + A +| Lymphoid Tissue, Hyperplasia | | __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + A + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + A + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Eosinophilic Focus | X X X X X | Hematopoietic Cell Proliferation | 2 1 2 1 | Inflammation, Chronic | | Necrosis | 1 2 | Vacuolization Cytoplasmic | | Bile Duct, Hyperplasia | | Centrilobular, Necrosis | 3 | __________________________________________________________________________| Mesentery | + + + + + + + | Fat, Inflammation, Chronic | | Fat, Necrosis | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 | Hypertrophy | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | X | Ulcer | | Epithelium, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + M + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy | 1 | Capsule, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6| DAY ON TEST | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3| | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M M M + + + + + M + M + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia | 4 3 4 2 1| Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 2 1 1 2 2 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + M M + + + + M + + + + M + + M + M + +| __________________________________________________________________________| Ovary | + + + + + + + + + I + + + + + I + + + + + + + + +| Angiectasis | | Atrophy | 2 2 | Cyst | 1 2 1 2 4 | Hemorrhage | | Granulosa Cell, Hyperplasia | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 3 4 2 4 | Hyperplasia, Cystic | 2 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + + + | Renal, Hyperplasia | 3 | __________________________________________________________________________| Lymph Node, Bronchial | M M M M + + M + + + + + + + + M M M + + + M + + +| Congestion | 2 | Hematopoietic Cell Proliferation | 2 | Hyperplasia | 2 2 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + M M + + + + + + + + M M +| Angiectasis | | Hyperplasia | 2 | Infiltration Cellular, Mast Cell | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | 4 2 | Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6| DAY ON TEST | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3| | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + M + + + M + + + M + + M + + + +| Hyperplasia | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 4 1 1 4 3 4 2 2 2 3 2 | Hyperplasia, Lymphoid | 2 2 2 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + M M M + + + + + + +| Angiectasis | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 1 2 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Infiltration Cellular, Histiocyte | 2 2 3 4 1 2 2 | Thrombosis | 2 | Alveolar Epithelium, Hyperplasia | | Bronchiole, Hyperplasia | 2 1 2 1 1 2 3 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mast Cell | 2 | Inflammation, Suppurative | 1 | Olfactory Epithelium, Atrophy | 1 | Olfactory Epithelium, Hyperplasia, | | Adenomatous | 1 | Olfactory Epithelium, Metaplasia | 1 | Olfactory Epithelium, Glands, | | Inflammation, Acute | | Respiratory Epithelium, Degeneration,| | Hyaline | 1 2 1 1 2 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 4| 7| 6| 6| 5| 5| 7| 2| 6| 7| 4| 7| 6| 6| 6| DAY ON TEST | 0| 3| 2| 2| 3| 0| 3| 9| 3| 8| 4| 3| 7| 7| 5| 4| 3| 8| 9| 3| 4| 3| 9| 2| 3| | 7| 5| 3| 4| 4| 2| 5| 1| 4| 0| 0| 5| 3| 7| 1| 8| 5| 5| 1| 5| 7| 5| 0| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Eye | + | Inflammation | 4 | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Metaplasia, Osseous | 1 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Pigmentation, Hemosiderin | | __________________________________________________________________________| Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3| | DAY ON TEST | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2| | | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + A| 48 | Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Gallbladder | + + + + + + A + + + + + + + + + + + + + + + + + A| 44 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | Inflammation, Suppurative | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + A| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 | Lymphoid Tissue, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + A| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + A| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Angiectasis | 4 2 | 3 3.3| Eosinophilic Focus | X X X X X X X | 12 | Hematopoietic Cell Proliferation | 2 | 5 1.6| Inflammation, Chronic | 3 | 1 3.0| Necrosis | 1 2 4 | 5 2.0| Vacuolization Cytoplasmic | 2 3 | 2 2.5| Bile Duct, Hyperplasia | 1 | 1 1.0| Centrilobular, Necrosis | 2 | 2 2.5| __________________________________________________________________________|____________| Mesentery | + + + + + + + | 14 | Fat, Inflammation, Chronic | 2 | 1 2.0| Fat, Necrosis | 2 2 | 3 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Atrophy | 1 1 1 | 6 1.0| Hypertrophy | 1 1 | 3 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Inflammation | 4 | 1 4.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Diverticulum | X | 2 | Ulcer | 2 2 | 2 2.0| Epithelium, Hyperplasia | 3 4 4 | 3 3.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 | 35 1.0| Atrium, Thrombosis | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3| | DAY ON TEST | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2| | | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Hypertrophy | 2 | 2 1.5| Capsule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M + M M + + + + M + + + M M + + + + + M + M| 35 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | Pars Distalis, Angiectasis | 1 | 1 1.0| Pars Distalis, Hyperplasia | 1 1 1 | 8 2.1| Pars Intermedia, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Follicular Cell, Hyperplasia | 3 1 2 2 1 1 2 | 15 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + M + + + + + + + M + + + + A| 40 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | Angiectasis | 2 | 1 2.0| Atrophy | 3 2 2 3 2 3 | 8 2.4| Cyst | 4 1 1 2 4 2 1 3 1 3 2 1 3 | 18 2.1| Hemorrhage | 3 | 1 3.0| Granulosa Cell, Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hydrometra | 4 4 | 6 3.5| Hyperplasia, Cystic | 2 | 3 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Atrophy | 4 | 1 4.0| Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node | | 3 | Renal, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + + M + + + M + M + + + M + + + M M M + + A| 31 | Congestion | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3| | DAY ON TEST | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2| | | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | | 1 2.0| Hyperplasia | | 3 2.3| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + M + + + + + M + + M + + + + + + M A| 40 | Angiectasis | 3 | 1 3.0| Hyperplasia | 2 | 2 2.0| Infiltration Cellular, Mast Cell | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + M + + + M + + A| 45 | Angiectasis | 2 | 1 2.0| Hematopoietic Cell Proliferation | | 2 3.0| Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + M| 44 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hematopoietic Cell Proliferation | 2 2 2 3 3 1 2 2 3 3 2 2 | 25 2.4| Hyperplasia, Lymphoid | 2 | 5 2.0| __________________________________________________________________________|____________| Thymus | M M M M + + + + + + + M + + + M M + M M + + + M M| 35 | Angiectasis | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Inflammation, Chronic Active | 4 4 | 3 3.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Fibrous Osteodystrophy | 2 1 2 1 1 2 1 | 11 1.4| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hemorrhage | 4 | 1 4.0| Infiltration Cellular, Histiocyte | 1 2 1 1 1 2 4 | 14 2.0| Thrombosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 6| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 6| 5| 6| 7| 6| 7| 6| 3| | DAY ON TEST | 3| 3| 5| 7| 1| 1| 9| 3| 0| 3| 3| 3| 3| 3| 9| 1| 8| 3| 4| 9| 0| 2| 3| 3| 2| | | 5| 1| 1| 4| 8| 9| 1| 4| 8| 4| 5| 5| 5| 5| 0| 9| 2| 6| 0| 8| 8| 3| 4| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| Bronchiole, Hyperplasia | 3 2 2 2 2 4 1 | 15 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Infiltration Cellular, Mast Cell | | 1 2.0| Inflammation, Suppurative | | 1 1.0| Olfactory Epithelium, Atrophy | 1 1 2 1 | 5 1.2| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | 1 1 | 3 1.0| Olfactory Epithelium, Metaplasia | 1 1 | 3 1.0| Olfactory Epithelium, Glands, | | | Inflammation, Acute | 2 | 1 2.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 | 9 1.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Inflammation | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + | 6 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hydronephrosis | 2 | 1 2.0| Metaplasia, Osseous | | 1 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 35 1.0| Pigmentation, Hemosiderin | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6| DAY ON TEST | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0| | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + M + + A + + + + + M + + + + + A + + + +| Degeneration, Hyaline | 2 | Inflammation, Suppurative | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + I + + + + + + A + + + + A + + + +| Lymphoid Tissue, Hyperplasia | 1 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + A + A + + + + A + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + A + + + + A + + + +| Peyer's Patch, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 2 3 | Degeneration, Fatty | | Eosinophilic Focus | X X X X X X X| Hematopoietic Cell Proliferation | 1 2 1 | Mineralization | | Necrosis | 2 2 2 1 1 1 3 | Bile Duct, Hyperplasia | | Centrilobular, Degeneration | 1 | Centrilobular, Necrosis | 2 1 | __________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + +| Hemorrhage | 2 | Fat, Necrosis | 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 | Hypertrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 1 1 | Epithelium, Hyperplasia | 2 2 3 1 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 2 2| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mineralization | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hypertrophy | 1 | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6| DAY ON TEST | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0| | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Inflammation, Focal, Granulomatous | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | M + + M + + + + + M + M + M + M + + + M + M + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + M + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia | 3 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + M + M + M + + + + M + + + + + I + + + + M M| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + M M| Atrophy | 2 1 2 3 2 | Cyst | 2 4 3 | Granulosa Cell, Hyperplasia | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Hydrometra | 3 | Hyperplasia, Cystic | 2 | Inflammation, Suppurative | 4 2| __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + | Hyperplasia | | Iliac, Hyperplasia | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M + M M + + M + M M + M + M + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia | 2 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + I + + + M + M + M M M I M + M + + + + + M M| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + M + + + + + +| Hematopoietic Cell Proliferation | 2 | Hyperplasia | 3 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6| DAY ON TEST | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0| | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 4 3 4 3 3 4 2 2 2 3 3 2 2 2 3 2 3 2 4 4 2 4 2 3| Hyperplasia, Lymphoid | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + M + + M + + M + +| Atrophy | 2 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 2 1 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | Inflammation, Suppurative | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Infiltration Cellular, Histiocyte | 2 2 3 2 3 2 2 2 3 | Alveolar Epithelium, Hyperplasia | | Bronchiole, Hyperplasia | 2 3 1 2 1 2 2 2| Perivascular, Infiltration Cellular | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Nasolacrimal Duct, Inflammation, | | Suppurative | | Olfactory Epithelium, Atrophy | 1 | Olfactory Epithelium, Metaplasia | | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 | Respiratory Epithelium, Necrosis | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 4| 5| 5| 2| 5| 6| 6| 6| 4| 5| 4| 6| 7| 6| 6| 6| 5| 5| 5| 4| 5| 5| 5| 6| DAY ON TEST | 3| 4| 3| 3| 1| 0| 0| 4| 3| 6| 4| 9| 7| 3| 9| 3| 5| 2| 3| 8| 8| 8| 1| 0| 0| | 1| 0| 7| 9| 6| 3| 8| 9| 5| 3| 3| 9| 4| 5| 1| 4| 6| 7| 1| 8| 7| 2| 5| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 2 | Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 | Papilla, Necrosis | | Renal Tubule, Necrosis | 2 3 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + A M + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6| | DAY ON TEST | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5| | | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + M + A + + + + + + + + + + + + + + + M + + A + +| 42 | Degeneration, Hyaline | 2 | 2 2.0| Inflammation, Suppurative | 1 2 | 2 1.5| __________________________________________________________________________|____________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + A + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + A + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + A + +| 45 | Lymphoid Tissue, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + A + + + + + + + + + + + + + + + + + + A + +| 42 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + A + + + + + + + + + + + + + + + + + + A + +| 44 | Peyer's Patch, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + A + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 4 2.8| Degeneration, Fatty | 2 2 | 2 2.0| Eosinophilic Focus | X X X X X X X X | 15 | Hematopoietic Cell Proliferation | 1 2 2 2 1 2 | 9 1.6| Mineralization | 2 | 1 2.0| Necrosis | 2 2 1 3 1 2 | 13 1.8| Bile Duct, Hyperplasia | 1 | 1 1.0| Centrilobular, Degeneration | 2 | 2 1.5| Centrilobular, Necrosis | | 2 1.5| __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + | 27 | Hemorrhage | | 1 2.0| Fat, Necrosis | 2 | 2 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + M A + +| 48 | Atrophy | 1 3 | 5 1.4| Hypertrophy | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Ulcer | 1 | 3 1.0| Epithelium, Hyperplasia | 1 1 1 | 8 1.6| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Necrosis | | 3 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 2 1 1 2 2 1 2 1 1 1 1 1 1 2 | 34 1.1| Mineralization | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6| | DAY ON TEST | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5| | | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Hematopoietic Cell Proliferation | 2 2 | 2 2.0| Hypertrophy | 1 1 | 3 1.0| Inflammation, Focal, Granulomatous | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + I + + + + + + + + + + + + + A + +| 48 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M A + +| 48 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + I M I + + + + M + M + + M M + + M + + M + M| 31 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Angiectasis | 4 | 1 4.0| Pars Distalis, Hyperplasia | 4 1 1 4 | 7 2.6| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Follicular Cell, Hyperplasia | 3 2 3 1 2| 8 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M M + + M + M M + + M + + + M + + + M M + + + + M| 32 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 | Atrophy | 4 1 | 7 2.1| Cyst | 2 1| 5 2.4| Granulosa Cell, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 2 3.0| Hydrometra | 4 | 2 3.5| Hyperplasia, Cystic | 1 | 2 1.5| Inflammation, Suppurative | | 2 3.0| __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Hyperplasia | 2 2 | 3 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + | 5 | Hyperplasia | 3 | 1 3.0| Iliac, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + M + + + + M + + + M M + + M + M + + M + +| 34 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6| | DAY ON TEST | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5| | | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | 3 | 1 3.0| Hyperplasia | 2 2 | 4 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + M M M + + + + M + M + + + +| 33 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + A + +| 48 | Angiectasis | 2 | 1 2.0| Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + M + + M + + + +| 45 | Hematopoietic Cell Proliferation | | 1 2.0| Hyperplasia | 3 3 2 2 2 | 7 2.6| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Hematopoietic Cell Proliferation | 2 4 3 2 2 3 3 3 4 2 4 4 2 2 4 2 3 2| 42 2.8| Hyperplasia, Lymphoid | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + M + + + M + M M M M + + M + + + + + A + +| 39 | Atrophy | 2 | 3 2.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 2 1 | 6 1.8| __________________________________________________________________________|____________| Skeletal Muscle | + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| Inflammation, Suppurative | | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 4.0| Infiltration Cellular, Histiocyte | 3 2 4 1 3 3 1 2 2| 18 2.3| Alveolar Epithelium, Hyperplasia | 3 | 1 3.0| Bronchiole, Hyperplasia | 3 4 2 2 | 12 2.2| Perivascular, Infiltration Cellular | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 4| 5| 3| 5| 6| 3| 5| 6| 6| 6| 3| 6| 6| 7| 6| 3| 5| 5| 4| 6| 6| | DAY ON TEST | 0| 2| 5| 7| 2| 2| 4| 7| 7| 8| 9| 4| 5| 2| 9| 2| 2| 1| 2| 7| 5| 2| 5| 6| 5| | | 7| 3| 1| 2| 5| 4| 6| 2| 1| 9| 6| 4| 6| 0| 4| 9| 9| 7| 4| 8| 1| 3| 4| 7| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Inflammation, Suppurative | 3 1 1 | 3 1.7| Nasolacrimal Duct, Inflammation, | | | Suppurative | 1 | 1 1.0| Olfactory Epithelium, Atrophy | 1 1 2 | 4 1.3| Olfactory Epithelium, Metaplasia | 2 | 1 2.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 2 2 1 1 2 1 | 10 1.3| Respiratory Epithelium, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Hydronephrosis | 4 3 4 | 4 3.3| Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1| 25 1.1| Papilla, Necrosis | 2 | 1 2.0| Renal Tubule, Necrosis | 3 | 4 2.8| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + A + +| 46 | Hemorrhage | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3| DAY ON TEST | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2| | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + A + + + + + + + + + + + + M + + A + + + A| Inflammation, Suppurative | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + M + + + + + + M + + + + + + + + + M + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| Necrosis | | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Basophilic Focus | X | Eosinophilic Focus | X X X X X X X X X X X X X| Hematopoietic Cell Proliferation | 1 2 1 1 1 2| Hyperplasia, Lymphoid | | Mineralization | | Necrosis | 1 2 2 2| Regeneration | | Vacuolization Cytoplasmic | | Bile Duct, Cyst | | Bile Duct, Hyperplasia | 2 1 1| Centrilobular, Degeneration | 2 | Centrilobular, Necrosis | 2 2 | __________________________________________________________________________| Mesentery | + + + + + + + + + | Angiectasis | | Fat, Necrosis | 2 2 4 3 2 3 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | 1 1 | Hyperplasia | | Hypertrophy | 1 | Duct, Cyst | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 3 4 | Inflammation, Suppurative | 2 2 1 | Ulcer | 2 1 | Epithelium, Hyperplasia | 2 2 2 2 3 3 2 2 4 2 2 4 2| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Hyaline | | Inflammation, Suppurative | 2 | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3| DAY ON TEST | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2| | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 | Artery, Inflammation | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 | Hypertrophy | 2 | Necrosis | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Necrosis | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + M + + M + + M M + + + + + + + + + M + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 1 1 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + M + + M M + + + + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| Atrophy | 2 2 2 | Cyst | 2 | Fibrosis | | Hemorrhage | | Corpus Luteum, Hyperplasia | 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hemorrhage | 2 | Hydrometra | 4 3 2 4| Hyperplasia, Cystic | 4 3 | Endometrium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3| DAY ON TEST | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2| | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Angiectasis | 2 | Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + + | Iliac, Hyperplasia | 4 | __________________________________________________________________________| Lymph Node, Bronchial | + + + M + + + M + + + + + M + + M + + M + M + + +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + M M + + + M + M + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia | 2 4 4 3 | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + M + + + + + + + + + + + + + +| Congestion | | Hematopoietic Cell Proliferation | | Hemorrhage | | Hyperplasia | | Inflammation, Chronic | | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + I + + + + + + + + + + + + M + + + M + + +| Hyperplasia | 2 2 3 3 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 4 4 3 4 3 3 2 4 3 4 4 3 2 4 2 3 2 4| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + M M + + + I M + + + + + + + + + + + + + + + + M| Atrophy | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | | Hyperplasia | 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Sebaceous Gland, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 1 4 1 1 1 | Fracture | | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 1 | Inflammation, Suppurative | 1 | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 4| 7| 6| 6| 5| 5| 2| 6| 6| 5| 5| 4| 5| 6| 7| 7| 4| 5| 6| 6| 3| DAY ON TEST | 6| 7| 0| 7| 5| 3| 5| 5| 2| 6| 5| 2| 1| 8| 3| 6| 2| 3| 3| 3| 4| 2| 7| 3| 2| | 7| 9| 7| 6| 3| 4| 2| 9| 3| 5| 2| 4| 0| 2| 1| 3| 4| 1| 5| 5| 3| 4| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Epiglottis, Hyperplasia | 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hemorrhage | 1 | Infiltration Cellular, Histiocyte | 3 2 3 2 4 2 2 2 3| Inflammation, Chronic, Focal | | Alveolar Epithelium, Hyperplasia | 2 1 2 | Bronchiole, Hyperplasia | 3 2 3 3 2 2 1 2 2 3 4 2 2 2 2| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Inflammation, Suppurative | 2 | Metaplasia | 1 | Olfactory Epithelium, Atrophy | 2 3 2 2 2 3 3 2 2 2 2 3 2 2 2 1 2 3 2 2 2 2 2 1| Olfactory Epithelium, Hyperplasia, | | Adenomatous | 1 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2| Olfactory Epithelium, Metaplasia | 2 3 2 2 2 3 2 2 2 2 2 3 2 1 2 3 2 2 2 2 1 1| Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 1 1 1 2 1 1 1 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | +| __________________________________________________________________________| Harderian Gland | + + + + + + | __________________________________________________________________________| Zymbal's Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | 1 | Nephropathy | 1 1 1 1 1 1 1 1 | Pigmentation, Hemosiderin | 2 | __________________________________________________________________________| Urinary Bladder | I + + + A + + + + + + + + + + + + M + + + + + + +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6| | DAY ON TEST | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3| | | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + M + + + + + + M + + + + + + + + A + + M + +| 42 | Inflammation, Suppurative | 1 | 2 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Necrosis | 2 | 1 2.0| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 4.0| Basophilic Focus | X | 2 | Eosinophilic Focus | X X 4 X X X X X X X X X X X X| 28 4.0| Hematopoietic Cell Proliferation | 1 2 3 1 1 2 | 12 1.5| Hyperplasia, Lymphoid | 2 | 1 2.0| Mineralization | 1 | 1 1.0| Necrosis | 1 1 1 | 7 1.4| Regeneration | 2 | 1 2.0| Vacuolization Cytoplasmic | 4 | 1 4.0| Bile Duct, Cyst | 2 | 1 2.0| Bile Duct, Hyperplasia | | 3 1.3| Centrilobular, Degeneration | 1 4 | 3 2.3| Centrilobular, Necrosis | 2 | 3 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + +| 21 | Angiectasis | 2 | 1 2.0| Fat, Necrosis | 2 3 1 4 2 3 4 2 3 4 | 18 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Atrophy | 1 | 3 1.0| Hyperplasia | 1 | 1 1.0| Hypertrophy | 1 1 1 | 4 1.0| Duct, Cyst | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 3 3.7| Inflammation, Suppurative | 2 3 1 2 2 | 8 1.9| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6| | DAY ON TEST | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3| | | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Ulcer | 2 2 2 | 5 1.8| Epithelium, Hyperplasia | 2 4 4 4 2 2 2 2 4 4 4 1 2 4 | 27 2.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Hyaline | 1 | 1 1.0| Inflammation, Suppurative | 1 1 2 | 4 1.5| Epithelium, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 33 1.1| Artery, Inflammation | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | | 1 1.0| Hypertrophy | 1 | 2 1.5| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1| 1 1.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M M + + + + M M + + M + + M + + M| 37 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 4 1 1 1 3 3 2 | 9 1.9| Pars Intermedia, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 2 | 4 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + M + M + M + + M M M + + + + + M M + + + M + M| 35 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 2 2 2 | 6 2.0| Cyst | 1 1 2 1 2 | 6 1.5| Fibrosis | 2 | 1 2.0| Hemorrhage | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6| | DAY ON TEST | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3| | | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Corpus Luteum, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 4 | 2 3.0| Hemorrhage | 4 | 2 3.0| Hydrometra | 3 2 3 3 | 8 3.0| Hyperplasia, Cystic | 4 | 3 3.7| Endometrium, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Hyperplasia | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Lymph Node | | 2 | Iliac, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + M + + + M + + M M M + + + + + + + + + +| 38 | Hyperplasia | 2 2 | 3 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + + M + + M M + M + + + +| 40 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | | 4 3.3| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + M + + + + + +| 46 | Congestion | 2 | 1 2.0| Hematopoietic Cell Proliferation | 4 | 1 4.0| Hemorrhage | 3 | 1 3.0| Hyperplasia | 4 2 | 2 3.0| Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M + + M + M + + M M + M + + + +| 40 | Hyperplasia | 2 2 | 7 2.3| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3 4 4 3 3 2 2 2 1 2 2 2 4 3 2 2 3 4 4| 39 2.9| Hyperplasia, Lymphoid | 2 3 | 3 2.3| __________________________________________________________________________|____________| Thymus | + + M + M + + + + M + + + + M + + + + + + M + + M| 39 | Atrophy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | 4| 1 4.0| Hyperplasia | 2 | 3 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sebaceous Gland, Hyperplasia | 2 | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6| | DAY ON TEST | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3| | | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 1 1 | 9 1.6| Fracture | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Inflammation, Chronic | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 | 5 1.2| Inflammation, Suppurative | | 1 1.0| Epiglottis, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Hemorrhage | | 1 1.0| Infiltration Cellular, Histiocyte | 2 2 3 2 2 3 2 2 3 2 2 2 4 2 | 23 2.4| Inflammation, Chronic, Focal | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 4 1.8| Bronchiole, Hyperplasia | 2 2 1 4 2 3 3 2 2 2 2 1 4 1 1 | 30 2.2| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 4 | 1 4.0| Inflammation, Suppurative | 2 1 1 | 4 1.5| Metaplasia | | 1 1.0| Olfactory Epithelium, Atrophy | 3 2 2 2 3 1 2 1 1 2 2 2 2 1 3 2 2 1 2 2 3 2 2| 47 2.0| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2| 44 1.9| Olfactory Epithelium, Metaplasia | 3 2 2 2 3 1 2 1 1 2 2 2 1 3 2 2 1 2 1 2 2 2| 44 2.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 2 1 2 1 1 2 1 1 1 2 1| 25 1.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + | 9 | __________________________________________________________________________|____________| Zymbal's Gland | + | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 3| 5| 6| 6| 6| 3| 4| 6| 6| 0| 6| 5| 4| 6| 6| 6| 5| 5| 6| 6| 5| 6| | DAY ON TEST | 3| 3| 1| 8| 9| 7| 3| 3| 3| 8| 3| 2| 0| 6| 4| 6| 4| 8| 6| 3| 7| 3| 4| 2| 3| | | 1| 2| 5| 3| 6| 3| 1| 5| 6| 4| 2| 9| 3| 3| 8| 2| 9| 0| 6| 8| 9| 5| 9| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Osseous | | 1 1.0| Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1| 20 1.1| Pigmentation, Hemosiderin | 2 2| 3 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + M M + + + + I A + + + + + +| Degeneration, Hyaline | 2 | Inflammation, Suppurative | 1| Necrosis | 1 | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + M + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + A + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X | Clear Cell Focus | X| Congestion | | Degeneration, Cystic | | Eosinophilic Focus | X X X X | Hematopoietic Cell Proliferation | 2 | Karyomegaly | 1 2 2 1 1 1 1 2 | Necrosis | 2 2 4 4 1 1 | Regeneration | 2 3 4 3 2 3 3 4 3 3 | Vacuolization Cytoplasmic | 1| Bile Duct, Hyperplasia | 2 3 2 2 2 3 2 1 2 3 2 2 2 1 | __________________________________________________________________________| Mesentery | | Fat, Inflammation, Chronic | | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1| Hypertrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | Epithelium, Hyperplasia | 4 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Necrosis | 1 2 | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Cardiomyopathy | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 | Hypertrophy | 1 1 1 1 1 1 1 1| Capsule, Hyperplasia | 2 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + + + M + + + M + M + + + + + M + I + M M + M + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 4 4 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 | Inflammation | 1 3 | __________________________________________________________________________| Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + + + +| Inflammation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1| Inflammation, Focal, Granulomatous | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 | __________________________________________________________________________| Lymph Node, Bronchial | M + M M M + + M + + + + M + + + + + M + + + + M +| Hyperplasia | 3 2 | __________________________________________________________________________| Lymph Node, Mandibular | M M M + M M + M M + + M M + + M + + + M + + I + M| Hyperplasia | 3 2 | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + M M + + + M + M M + + + + + + M M M +| Hyperplasia | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 2 1 2 3 2 2 2 1 3 3 | Hyperplasia, Lymphoid | 2 1 2 | __________________________________________________________________________| Thymus | M + M M M + + M M + + + + M I + M + + I + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Prepuce, Inflammation, Chronic Active| 4 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 | Epiglottis, Metaplasia, Squamous | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 1 2 | Thrombosis | | Alveolar Epithelium, Hyperplasia | 1 1 | Perivascular, Infiltration Cellular | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 3 | Olfactory Epithelium, Atrophy | 1 1 1 2 | Olfactory Epithelium, Hyperplasia, | | Adenomatous | 1 | Olfactory Epithelium, Metaplasia | 1 1 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Squamous | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 0| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| | 6| 3| 3| 9| 3| 3| 3| 3| 3| 4| 5| 8| 5| 4| 4| 4| 3| 4| 7| 6| 4| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Eye | + | Inflammation | 4 | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 2 4 | Metaplasia, Osseous | 1 | Nephropathy | 1 1 2 2 2 1 2 1 1 1 1 1 2 2 1 1 2 2 1 1 1 1 1| Papilla, Necrosis | 3 | Renal Tubule, Necrosis | | __________________________________________________________________________| Ureter | + | Transitional Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 3 | Transitional Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7| | DAY ON TEST | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3| | | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + M + + + M + + + + A + + + + A + A +| 41 | Degeneration, Hyaline | 2 3 2 3 | 5 2.4| Inflammation, Suppurative | | 1 1.0| Necrosis | | 1 1.0| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + A + M +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + A + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + A + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 3 | 2 2.5| Basophilic Focus | X | 4 | Clear Cell Focus | | 1 | Congestion | 3 | 1 3.0| Degeneration, Cystic | 4 | 1 4.0| Eosinophilic Focus | X X X | 7 | Hematopoietic Cell Proliferation | | 1 2.0| Karyomegaly | 2 1 2 3 3 1 1 1 1 1 1 | 19 1.5| Necrosis | 4 4 1 | 9 2.6| Regeneration | 4 2 2 2 3 3 2 4 2 2 4 2| 22 2.8| Vacuolization Cytoplasmic | | 1 1.0| Bile Duct, Hyperplasia | 3 2 2 2 2 2 3 2 2 1 2 4 1 2 2 3 1 2 1 2| 34 2.1| __________________________________________________________________________|____________| Mesentery | + + | 2 | Fat, Inflammation, Chronic | 4 | 1 4.0| Fat, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 | 4 1.0| Hypertrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 2 | 2 2.0| Epithelium, Hyperplasia | 2 4 | 4 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 2.0| Necrosis | | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7| | DAY ON TEST | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3| | | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tooth | + | 2 | Developmental Malformation | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 43 1.1| Atrium, Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 2 1.5| Hypertrophy | 1 1 2 1 1 | 13 1.1| Capsule, Hyperplasia | | 2 2.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 | 3 2.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + M + M M + + + + M + I + M + + + + + + + M + +| 35 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Hyperplasia | 1 | 1 1.0| Pars Intermedia, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 1 2 1| 5 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 1 | 3 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 2 3.0| Inflammation | | 2 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 1 | 2 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation | 2 3 | 2 2.5| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7| | DAY ON TEST | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3| | | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Atrophy | 2 | 2 1.5| Inflammation, Focal, Granulomatous | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 3 2.7| __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + M + + M M + M + + + + M + + + + + M M M| 32 | Hyperplasia | 2 2 | 4 2.3| __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + M + M + + + M + + + M + + +| 32 | Hyperplasia | | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + + + + M + + + + + + + + + M + + +| 47 | Hyperplasia | 2 | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + M M + + + + + + M + + M + + + + + + + M + M M| 34 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3 3 2 3 3 3 2 2 2 4 2 3 2 3 2| 26 2.5| Hyperplasia, Lymphoid | 2 2 | 5 1.8| __________________________________________________________________________|____________| Thymus | + + + M + + M + M M + + + + + + M + + + + + + + +| 34 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Inflammation, Chronic Active | 3 | 1 3.0| Prepuce, Inflammation, Chronic Active| 2 4 | 4 3.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Inflammation, Chronic | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 3 1.0| Epiglottis, Metaplasia, Squamous | | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 1 2 2 2 | 7 1.6| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 4| 7| | DAY ON TEST | 3| 2| 7| 3| 8| 3| 3| 0| 1| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 8| 8| 7| 3| 5| 3| | | 4| 2| 4| 3| 0| 3| 3| 7| 9| 6| 3| 8| 3| 3| 4| 9| 3| 5| 4| 4| 4| 0| 3| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Thrombosis | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 | 3 1.3| Perivascular, Infiltration Cellular | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 2 2.0| Olfactory Epithelium, Atrophy | 1 1 1| 7 1.1| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | 1 1| 3 1.0| Olfactory Epithelium, Metaplasia | 1 1 1| 6 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 | 3 1.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Squamous | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Inflammation | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 1 | 1 1.0| Inflammation, Chronic Active | 2 2 | 4 2.5| Metaplasia, Osseous | 1 1 | 3 1.0| Nephropathy | 1 2 1 1 2 1 1 2 1 1 1 3 1 2 1 1 2 1 1 1 1 1 1 1| 47 1.3| Papilla, Necrosis | | 1 3.0| Renal Tubule, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Ureter | | 1 | Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 3 | 3 2.7| Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7| DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3| | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + + + M A + + + + A + + + + + + + + + + +| Degeneration, Hyaline | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + A + + + + A + + + + + + + + + + +| Necrosis | 4 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + A + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + A + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 2 | Basophilic Focus | X | Clear Cell Focus | X | Degeneration, Cystic | 3 | Eosinophilic Focus | X X X | Hematopoietic Cell Proliferation | | Karyomegaly | 1 1 2 2 1 1 2 | Necrosis | 4 4 4 1 2 | Regeneration | 2 4 3 2 4 4 2 3 2 4 | Bile Duct, Hyperplasia | 2 3 2 2 2 3 3 2 1 2 2 2 2 1| __________________________________________________________________________| Mesentery | + + + + | Fat, Inflammation, Chronic | 3 | Fat, Necrosis | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| Atrophy | 1 1 | Cytoplasmic Alteration | | Hypertrophy | | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| Infiltration Cellular, Mast Cell | | Inflammation, Suppurative | | Ulcer | 2 2 | Epithelium, Hyperplasia | 2 3 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| Inflammation, Suppurative | | Mineralization | | __________________________________________________________________________| Tooth | | Developmental Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Mineralization | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7| DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3| | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 | Hypertrophy | 1 1 1 1 1 2 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + M + M + + M + + + + + M + I + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + M + + + + + + + + + + + + M + + + + +| Cyst | 3 3 3 | Inflammation | 2 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | Inflammation, Suppurative | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + A + + + + + + + + + + +| Inflammation | 2 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Infiltration Cellular, Mast Cell | | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Bronchial | + + + M M + + M M M M M + + + + + M + M + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + M + M + + M M M + + + + + + + M M + + +| Hyperplasia | 4| Infiltration Cellular, Mast Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7| DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3| | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Angiectasis | 2 | Hyperplasia | 3 2| __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + M M + M + + + + + + + + + + + M I + + M| Hyperplasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 1 1 2 3 2 2 2 2 2 2| Hyperplasia, Lymphoid | 3 2 | __________________________________________________________________________| Thymus | M + + + + M + + + + + + + + + M + M M M M I + M I| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + M + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4| Prepuce, Inflammation, Chronic Active| 3 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + M + + + + + + + + A + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Infiltration Cellular, Histiocyte | 3 3 4 3| Inflammation, Chronic, Focal | 3 | Alveolar Epithelium, Hyperplasia | 4 2 3 1 | Bronchiole, Hyperplasia | 1 2 1 | Mediastinum, Inflammation, Chronic | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + A + + + + + + + + + + +| Inflammation, Suppurative | 1 | Nasolacrimal Duct, Inflammation, | | Suppurative | | Olfactory Epithelium, Atrophy | 2 1 1 | Olfactory Epithelium, Hyperplasia, | | Adenomatous | 1 | Olfactory Epithelium, Metaplasia | 2 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 | Respiratory Epithelium, Polyp, | | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 5| 7| 7| 5| 5| 6| 7| 6| 7| 7| 6| 7| DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 8| 3| 2| 3| 3| 7| 9| 3| 3| 8| 3| 2| 3| 3| | 2| 3| 4| 3| 3| 3| 4| 4| 6| 3| 1| 3| 3| 3| 3| 4| 9| 6| 5| 3| 8| 3| 2| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 12.8 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammatory | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Inflammation | | __________________________________________________________________________| Harderian Gland | + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hydronephrosis | 2 | Inflammation, Chronic Active | | Metaplasia, Osseous | | Mineralization | | Nephropathy | 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1| Renal Tubule, Hyperplasia | 1 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +| Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6| | | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + M + + + A + + M + + A + + A + + A + + + + +| 40 | Degeneration, Hyaline | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + A + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + M A + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + + + + A + + A + + A + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + + + A + + A + + A + + + + +| 44 | Necrosis | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + + + + A + + A + + A + + + + +| 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + A + + A + + + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 3 2.7| Basophilic Focus | X | 2 | Clear Cell Focus | | 1 | Degeneration, Cystic | | 1 3.0| Eosinophilic Focus | X X X X | 7 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Karyomegaly | 2 2 2 1 2 1 | 13 1.5| Necrosis | 4 2| 7 3.0| Regeneration | 2 3 3 3 4 4 4 3 4 2 4 2 4 4 2 | 25 3.1| Bile Duct, Hyperplasia | 1 2 3 2 3 2 3 2 4 2 4 3 2 2 3 3 1 | 31 2.3| __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Fat, Inflammation, Chronic | | 1 3.0| Fat, Necrosis | 3 | 2 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Atrophy | 1 1| 4 1.0| Cytoplasmic Alteration | 1 | 1 1.0| Hypertrophy | 1 | 1 1.0| Duct, Cyst | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Infiltration Cellular, Mast Cell | 2 | 1 2.0| Inflammation, Suppurative | 1 | 1 1.0| Ulcer | 1 | 3 1.7| Epithelium, Hyperplasia | 1 1 2 | 6 1.8| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Inflammation, Suppurative | 2 | 1 2.0| Mineralization | 4 | 1 4.0| __________________________________________________________________________|____________| Tooth | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6| | | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Developmental Malformation | X 4 | 2 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | Mineralization | 3 | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1| 43 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Hyperplasia | 2 | 4 1.8| Hypertrophy | 1 2 1 1 1 1 1 1 | 15 1.1| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Hyperplasia | 1 | 3 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Parathyroid Gland | + + M M + I + M + + M + + M M + + + + A M + M M M| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + A + + + + +| 47 | Pars Distalis, Hyperplasia | 2 1 | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Follicular Cell, Hyperplasia | 1 1 1 | 5 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 | Cyst | 2 3 2 2 | 7 2.6| Inflammation | 2 2| 4 2.3| __________________________________________________________________________|____________| Prostate | + + + M + + + + + + + + + + + + + + + A + + + + +| 48 | Hyperplasia | | 1 1.0| Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Inflammation | | 2 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Atrophy | 1 1 | 3 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6| | | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Hyperplasia | 2 | 1 2.0| Infiltration Cellular, Mast Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M M M M M M + + M M M M + M M + M M M M + + M| 23 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | I + + M M M M + M + M + + + + + + M M A M M M M +| 28 | Hyperplasia | 2 | 2 3.0| Infiltration Cellular, Mast Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Angiectasis | 2 2 | 3 2.0| Hyperplasia | | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + M + M + M + + + A + + + + M| 38 | Hyperplasia | 3 3 2 4 | 4 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Hematopoietic Cell Proliferation | 3 2 2 2 3 3 2 2 2 3 2 | 22 2.1| Hyperplasia, Lymphoid | 4 | 3 3.0| __________________________________________________________________________|____________| Thymus | + + M + + M M M + + + M M + + + M M + M M + + M M| 28 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Inflammation, Chronic Active | | 1 4.0| Prepuce, Inflammation, Chronic Active| 3 4 3 4| 6 3.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | | 1 1.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 | Hyperplasia | 2 1 | 2 1.5| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 4 3 2 4 | 8 3.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 9| 3| 3| 2| 3| 0| 3| 0| 5| 0| 3| 6| | | 4| 3| 3| 8| 3| 3| 3| 0| 4| 3| 3| 9| 4| 1| 3| 4| 6| 3| 7| 0| 8| 9| 1| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 12.8 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Chronic, Focal | 2| 2 2.5| Alveolar Epithelium, Hyperplasia | 1 | 5 2.2| Bronchiole, Hyperplasia | 2 2 2 4 1 3 2 | 10 2.0| Mediastinum, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Inflammation, Suppurative | | 1 1.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 | 1 2.0| Olfactory Epithelium, Atrophy | 2 1 2 1 1 | 8 1.4| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | 1 | 2 1.0| Olfactory Epithelium, Metaplasia | 1 2 1 1 | 5 1.4| Respiratory Epithelium, Degeneration,| | | Hyaline | 2 1 | 4 1.3| Respiratory Epithelium, Polyp, | | | Inflammatory | 4 | 1 4.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Inflammation | 4 | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | + + | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Cyst | 2 | 2 2.0| Hydronephrosis | | 1 2.0| Inflammation, Chronic Active | 2 4 | 2 3.0| Metaplasia, Osseous | 1 | 1 1.0| Mineralization | 3 | 1 3.0| Nephropathy | 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1| 44 1.2| Renal Tubule, Hyperplasia | 1 | 4 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Inflammation, Suppurative | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6| DAY ON TEST | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6| | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + A + M + + + + + + + A M + M + + M + A +| Degeneration, Hyaline | 3 | Inflammation, Suppurative | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + A +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + A M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + M + + + + + + + + + A + + + + + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + A +| Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Eosinophilic Focus | X X| Hematopoietic Cell Proliferation | | Karyomegaly | 2 2 2 2 2 2 2 1 2 2 | Mitotic Alteration | 3 | Necrosis | 2 4 4 | Regeneration | 2 2 2 3 3 3 4 4 4 3 2| Bile Duct, Hyperplasia | 2 3 2 3 2 2 1 3 4 2 2 2 1 3 3 3 2 3| Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + + + + + + + +| Angiectasis | 2 | Fat, Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +| Atrophy | | Basophilic Focus | | Cytoplasmic Alteration | 2| Hypertrophy | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +| Inflammation, Suppurative | 1 | Ulcer | 2 | Epithelium, Hyperplasia | 3 3 3 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Necrosis | 1 | Pigmentation | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Inflammation | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| Hyperplasia, Atypical | 1 | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6| DAY ON TEST | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6| | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Inflammation | 2 | Mineralization | | Artery, Inflammation | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1| Hypertrophy | 1 1 1 1 1 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | M + + M + M M M + M M + M + + + M + M + M + + + +| __________________________________________________________________________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 1 | Pars Nervosa, Inflammation | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 4 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | Hyperplasia | 2 | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Cyst | 2 | Inflammation | 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 4 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + A +| Inflammation | 4 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Lymph Node | + | Iliac, Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + M M M + + M + M + + M + + + + + + + M + M + I| _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6| DAY ON TEST | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6| | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + M M + M + + M + + + + + M M M M M M M M + M M| Hyperplasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + M M| Angiectasis | | Hyperplasia | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M M + + + M M + + M M + + M + + + + M +| Hematopoietic Cell Proliferation | 2 | Hyperplasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Hematopoietic Cell Proliferation | 3 2 2 2 2 4 1 3 2 3 1 3 1 4 2 3 1 3 3| __________________________________________________________________________| Thymus | + + + M M M M M + + M + + + M I + + + + M M + + I| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M + M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 3 | Inflammation, Chronic Active | 2 | Prepuce, Inflammation, Chronic Active| 3 3 4 | Subcutaneous Tissue, Cyst | 3 3 | Subcutaneous Tissue, Inflammation, | | Focal, Granulomatous | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 2 1 2 3 1 | Alveolar Epithelium, Hyperplasia | 2 2 | Bronchiole, Hyperplasia | 2 2 2 1 2 1 2 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Olfactory Epithelium, Atrophy | 1 1 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 | Olfactory Epithelium, Hyperplasia, | | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 6| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 6| 4| 6| 5| 7| 7| 4| 6| DAY ON TEST | 3| 4| 0| 3| 1| 0| 2| 9| 3| 9| 0| 3| 3| 3| 2| 1| 3| 8| 3| 0| 6| 1| 3| 7| 6| | 3| 9| 7| 5| 3| 7| 9| 5| 3| 1| 5| 4| 4| 4| 0| 5| 4| 8| 9| 2| 7| 7| 3| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 32 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Adenomatous | | Olfactory Epithelium, Metaplasia | 1 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hydronephrosis | | Inflammation, Chronic Active | 4 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 2 1 2 2 1 1 2 2 1 3 1| Pigmentation, Hemosiderin | | Renal Tubule, Hyperplasia | 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7| | | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + A + + + M + M + + + A + + M + + + + + + + + +| 37 | Degeneration, Hyaline | 4 | 2 3.5| Inflammation, Suppurative | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | A M + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + A + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | A + A + + + + + + + + + A + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | A + A + + + + + + + + + + + + + + + + + + + + + +| 46 | Peyer's Patch, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Eosinophilic Focus | X | 3 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Karyomegaly | 1 1 1 2 1 1 2 2 2 1 | 20 1.7| Mitotic Alteration | | 1 3.0| Necrosis | 1 3 2 4 | 7 2.9| Regeneration | 4 2 2 4 4 3 2 2 3 4 4 3 4 2 | 25 3.0| Bile Duct, Hyperplasia | 2 2 2 4 1 4 2 2 1 2 3 3 1 3 3 2 | 34 2.4| Centrilobular, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + +| 16 | Angiectasis | 2| 2 2.0| Fat, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 1 | 2 1.0| Basophilic Focus | X | 1 | Cytoplasmic Alteration | | 1 2.0| Hypertrophy | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 1 2 | 3 1.3| Ulcer | | 1 2.0| Epithelium, Hyperplasia | 2 1 3 | 7 2.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 1.0| Necrosis | | 1 1.0| Pigmentation | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7| | | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Inflammation | | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 40 1.1| Hyperplasia, Atypical | | 1 1.0| Inflammation | | 1 2.0| Mineralization | 1 | 1 1.0| Artery, Inflammation | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 | 3 1.0| Hypertrophy | 1 1 1 1 2 1 | 12 1.1| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 5 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Parathyroid Gland | M + + + M M + M M + M M + + + M + + + + + + + + +| 31 | __________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + + + + M + + + + + + + + + + + + +| 47 | Pars Distalis, Hyperplasia | | 1 1.0| Pars Nervosa, Inflammation | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 1 1 | 6 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 3 | 1 3.0| Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + M I + + + + + + + + + +| 47 | Cyst | 3 | 2 2.5| Inflammation | 1 2 | 3 1.7| __________________________________________________________________________|____________| Prostate | + + + M + + + + + + + + + + + + + + + + + + + + M| 48 | Inflammation, Suppurative | 3 | 2 3.5| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7| | | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Atrophy | 1 | 2 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 3 2.0| __________________________________________________________________________|____________| Lymph Node | +| 2 | Iliac, Hyperplasia | 2| 2 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + + + M M M M + + M + + + + + + + M + + +| 33 | Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M + M + M + + + + M + + M + M + + + M + + + + M M| 27 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + I + + + + + +| 46 | Angiectasis | 2 1 2 | 3 1.7| Hyperplasia | 4 4 | 2 4.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + M M + + + + + + M + M + + + + + + + + + +| 37 | Hematopoietic Cell Proliferation | | 1 2.0| Hyperplasia | 2 3 | 2 2.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | | 1 | Hematopoietic Cell Proliferation | 3 2 2 2 4 3 3 3 2 3 2 2 2 2 4 2| 35 2.5| __________________________________________________________________________|____________| Thymus | M M M + + + M M + + M M + M + M + M + M M M + M +| 25 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 2 3.0| Inflammation, Chronic Active | | 1 2.0| Prepuce, Inflammation, Chronic Active| 4 4| 5 3.6| Subcutaneous Tissue, Cyst | | 2 3.0| Subcutaneous Tissue, Inflammation, | | | Focal, Granulomatous | 3 | 2 3.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 6| 6| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 7| 3| 5| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 8| 9| 6| 3| 7| 6| 7| 5| 9| 3| 0| 3| 0| 3| 6| 4| 3| 8| 0| 2| 3| 3| 0| 8| 7| | | 8| 3| 3| 4| 9| 6| 9| 1| 6| 4| 7| 4| 6| 4| 5| 5| 3| 2| 2| 3| 4| 4| 1| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 32 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Meninges, Inflammation, Chronic | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 2 3 4 4 3 | 11 2.5| Alveolar Epithelium, Hyperplasia | | 2 2.0| Bronchiole, Hyperplasia | 2 1 1 2 1 2 1 1 4 3 | 18 1.7| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 1 1 | 4 1.0| Olfactory Epithelium, Atrophy | 1 1 1 1 | 7 1.1| Olfactory Epithelium, Degeneration, | | | Hyaline | | 1 1.0| Olfactory Epithelium, Hyperplasia, | | | Adenomatous | 1 1 | 2 1.0| Olfactory Epithelium, Metaplasia | 1 1 1 | 5 1.0| Respiratory Epithelium, Degeneration,| | | Hyaline | | 2 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + + + + + | 11 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Hydronephrosis | 1 | 1 1.0| Inflammation, Chronic Active | 3 2| 3 3.0| Nephropathy | 1 1 1 1 1 1 1 3 1 1 1 1 2 2 1 1 1 2 2 1 2| 43 1.3| Pigmentation, Hemosiderin | 2 | 1 2.0| Renal Tubule, Hyperplasia | 1 1 1 | 5 1.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + M + + + + + + + + + I + + + + + + +| 48 | Inflammation, Suppurative | 1 4| 3 2.7| Transitional Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 58 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6| DAY ON TEST | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5| | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 1 | Inflammation, Suppurative | 2 | Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Gallbladder | + + + M + + M + M M + + M I + + + + + + + M + + +| Degeneration, Hyaline | 2 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + M + + + + + M| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Basophilic Focus | | Eosinophilic Focus | X X X X X | Hematopoietic Cell Proliferation | 1 | Karyomegaly | 1 2 1 1 2 3 2 2 3 1 1 | Necrosis | 4 4 | Regeneration | 2 3 2 2 2 3 3 4 4 2 3 2| Bile Duct, Hyperplasia | 3 2 3 2 2 3 2 2 3 3 3 4 4 2 2 2| __________________________________________________________________________| Mesentery | + + + + + | Inflammation, Focal, Granulomatous | 2 | Thrombosis | | Fat, Necrosis | 3 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | Hyperplasia | | Hypertrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 | Ulcer | 2 2 2 2 1 2 2| Epithelium, Hyperplasia | 2 1 3 1 2 3 2 3 1 3 2 4 3| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Necrosis | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6| DAY ON TEST | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5| | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1| Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy | 1 1 | Capsule, Hyperplasia | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + M M M M I M M + + M M + + M + M + + + + + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 1 | Inflammation | 1| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | 2 3 2| Fibrosis | 2 | Inflammation | 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Lymph Node | + + | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + M M M + M M M + M + + + + M M + M M + M| Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M M + + M + + + M + M + M M M + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + M + + + +| Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + M I + + M + + + + + + M + + + M + + +| Hyperplasia | | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6| DAY ON TEST | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5| | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hematopoietic Cell Proliferation | 2 2 3 2 3 3 2 3 2 4 2 2 3 3 3 2 2| Infiltration Cellular, Histiocyte | | __________________________________________________________________________| Thymus | + M + I + M M + + + M + + + M + M M M + + + + M +| Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 4 4 | Epidermis, Hyperplasia | | Prepuce, Inflammation, Chronic Active| 4 | Subcutaneous Tissue, Inflammation, | | Suppurative | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | Inflammation, Suppurative | | Epiglottis, Metaplasia, Squamous | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 2 4 3 2 3 2 2 4 4 4| Inflammation, Chronic, Focal | | Alveolar Epithelium, Hyperplasia | | Bronchiole, Hyperplasia | 1 2 1 2 3 2 2 2 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 | Lateral Wall, Necrosis | | Olfactory Epithelium, Atrophy | 3 3 1 3 3 3 2 3 3 2 3 3 2 2 2 3 2 2 3 2 2 3 2 3| Olfactory Epithelium, Degeneration, | | Hyaline | | Olfactory Epithelium, Hyperplasia, | | Adenomatous | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2| Olfactory Epithelium, Metaplasia | 3 3 1 3 3 3 2 3 3 2 3 2 2 2 2 3 2 2 3 2 2 3 1 3| Respiratory Epithelium, Degeneration,| | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 _____________________________________________________________________________________________________________________ | 7| 4| 7| 3| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 4| 7| 5| 7| 7| 6| 6| 6| 6| 6| DAY ON TEST | 3| 2| 3| 9| 3| 2| 8| 0| 3| 3| 2| 0| 4| 3| 3| 5| 0| 7| 0| 3| 8| 5| 4| 5| 5| | 4| 2| 3| 2| 3| 4| 0| 3| 3| 4| 4| 8| 4| 5| 3| 4| 1| 9| 1| 3| 7| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 80 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hyaline | 1 1 1 1 | Respiratory Epithelium, Necrosis | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Inflammation | 4 | __________________________________________________________________________| Harderian Gland | + M M + + + + + | __________________________________________________________________________| Zymbal's Gland | M M M | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Glomerulosclerosis | 3 4 | Hydronephrosis | | Metaplasia, Osseous | | Nephropathy | 1 1 1 1 3 3 2 1 1 1 1 1 1 1 1 2 2 1 1| Pigmentation, Hemosiderin | 2 | Renal Tubule, Hyperplasia | 1 1 2 | Renal Tubule, Necrosis | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6| | DAY ON TEST | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5| | | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dysplasia | | 1 1.0| Inflammation, Suppurative | | 1 2.0| Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + M + M A + + + + + + + + + + +| 40 | Degeneration, Hyaline | 4 | 3 2.7| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A A + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | Inflammation, Suppurative | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | Peyer's Patch, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | Angiectasis | | 1 3.0| Basophilic Focus | 1 | 1 1.0| Eosinophilic Focus | X X X | 8 | Hematopoietic Cell Proliferation | 3 3 2 | 4 2.3| Karyomegaly | 3 2 3 1 1 1 2 3 2 2 1 3 1 1 2 1 2 4| 29 1.9| Necrosis | 1 4 4 4| 6 3.5| Regeneration | 4 4 4 2 2 4 3 4 4 3 2 3 2 4 4| 27 3.0| Bile Duct, Hyperplasia | 4 3 4 2 1 2 4 3 4 2 4 4 3 3 2 3 3 3 3 4| 36 2.9| __________________________________________________________________________|____________| Mesentery | + + + + + + | 11 | Inflammation, Focal, Granulomatous | | 1 2.0| Thrombosis | 3 | 1 3.0| Fat, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 | 2 1.0| Hyperplasia | 1 | 1 1.0| Hypertrophy | 1 1 | 2 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 1 2 | 5 1.8| Ulcer | 2 2 2 2 1 | 12 1.8| Epithelium, Hyperplasia | 2 3 3 2 1 1 3 2 2 2 1 2 3 2 4 2| 29 2.2| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + A A + + + + + + + + + + +| 48 | Mineralization | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 05136-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC CHLOROPRENE Date: 10/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:15:04 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 5| 7| 6| 6| 7| 6| 5| 5| 6| | DAY ON TEST | 9| 3| 8| 3| 3| 4| 3| 4| 0| 2| 3| 7| 2| 7| 3| 4| 2| 3| 2| 7| 3| 6| 6| 8| 5| | | 5| 3| 7| 5| 3| 9| 3| 4| 0| 8| 7| 7| 0| 2| 3| 9| 3| 3| 4| 7| 3| 3| 7| 9| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 80 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Necrosis | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 2| 45 1.2| Atrium, Thrombosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypertrophy | 1 1 1 1 1 1 1 | 9 1.0| Capsule, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 1 | 4 1.3| __________________________________________________________________________|____________| Parathyroid Gland | M + + + M + + + + + + + M + M + + + + + M + M + M| 30 | ______________________