National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2974

TDMS Study 05136-08 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 10/04/96       
EXPERIMENT: 05136 TEST: 08                                                                                     TIME: 10:29:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B       
PATHOLOGIST: R. MILLER                                                                                         CAS: 0000126-99-8    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 10/04/96      
EXPERIMENT: 05136 TEST: 08                                                                                     TIME: 10:29:16      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B      
PATHOLOGIST: R. MILLER                                                                                         CAS: 0000126-99-8   
                                    CHLOROPRENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      452   535   553   570   596   603   606   607   627   628                 |
 |      635   635   638   664   666   674   680   684   684   719                 |
 |      722   729   729                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 12.8 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      439   523   530   546   579   582   583   596   607   614                 |
 |      626   635   635   638   659   667   680   688   691   691                 |
 |      701   708   722                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 32 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 36     CENSORED DEATHS 0    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      382   439   470   491   495   502   545   551   565   567                 |
 |      579   596   602   606   607   607   607   620   623   629                 |
 |      635   649   663   666   666   679   679   680   688   688                 |
 |      693   701   705   713   715   717                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                    CHLOROPRENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 80 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 13        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      392   422   454   523   524   567   579   587   589   595                 |
 |      600   603   608   620   624   624   628   635   635   637                 |
 |      644   644   649   649   649   656   657   659   659   663                 |
 |      672   677   677   680   687   701   701                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                    CHLOROPRENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  88.0  72.0  54.0      |
 |           |                                                                    |
 |           |                                                                    |
 |12.8 PPM   |   100.0 100.0 100.0 100.0 100.0  98.0  94.0  84.0  70.0  54.0      |
 |           |                                                                    |
 |           |                                                                    |
 |32 PPM     |   100.0 100.0 100.0 100.0  98.0  94.0  86.0  74.0  54.0  28.0      |
 |           |                                                                    |
 |           |                                                                    |
 |80 PPM     |   100.0 100.0 100.0 100.0  96.0  94.0  90.0  76.0  40.0  26.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      12.8 PPM     32 PPM       80 PPM   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       54.0%        54.0%        28.0%        26.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=1.000      P=0.007      P=0.003  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       636.3        623.5        611.7        615.4    |
 |NATURAL DEATHS (C)      |       (14.1)       (14.6)       (14.0)       (11.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       688.5        682.6        645.6        646.0    |
 |(STANDARD ERROR)        |       ( 9.4)       (10.2)       (12.7)       (11.4)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                    CHLOROPRENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      35    477   486   493   527   541   610   635   637   663                 |
 |      677   681   705   706   729                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 12.8 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 1    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      285   321   440   447   482   523   531   540   548   551                 |
 |      551   607   621   623   624   631   631   636   673   674                 |
 |      677   680   690   690   691   691   691   698   702   708                 |
 |      708   719   719                                                           |
 |  CENSORED DEATHS                                                               |
 |      318                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 32 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 49     CENSORED DEATHS 0    TERMINAL 1         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      216   346   378   389   394   425   440   454   463   472                 |
 |      487   499   503   505   515   523   524   527   531   537                 |
 |      539   543   551   551   572   582   588   596   604   607                 |
 |      608   620   623   624   629   629   631   634   635   644                 |
 |      649   652   656   656   667   671   674   691   717                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                    CHLOROPRENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 80 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 46     CENSORED DEATHS 1    TERMINAL 3         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      252   324   336   383   443   453   462   463   467   484                 |
 |      523   524   524   524   531   531   538   548   565   576                 |
 |      579   579   582   596   607   610   615   624   629   631                 |
 |      631   631   632   632   635   635   638   649   649   652                 |
 |      659   663   666   673   674   680                                         |
 |  CENSORED DEATHS                                                               |
 |      3                                                                         |
 |                                                                                |
 ==================================================================================
                                    CHLOROPRENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    98.0  98.0  98.0  98.0  98.0  96.0  88.0  88.0  80.0  70.0      |
 |           |                                                                    |
 |           |                                                                    |
 |12.8 PPM   |   100.0 100.0 100.0  96.0  96.0  89.8  83.7  77.6  63.3  32.7      |
 |           |                                                                    |
 |           |                                                                    |
 |32 PPM     |   100.0 100.0  98.0  96.0  88.0  80.0  56.0  42.0  12.0   2.0      |
 |           |                                                                    |
 |           |                                                                    |
 |80 PPM     |   100.0 100.0  98.0  93.9  91.8  79.6  65.3  51.0  14.3   6.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      12.8 PPM     32 PPM       80 PPM   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       70.0%        32.7%         2.0%         6.1%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P<0.001      P<0.001      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       573.5        606.2        554.5        563.1    |
 |NATURAL DEATHS (C)      |       (44.5)       (19.5)       (14.6)       (14.8)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       685.8        641.3        558.1        562.1    |
 |(STANDARD ERROR)        |       (16.7)       (16.7)       (14.8)       (18.7)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                            CHLOROPRENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        12.8 PPM         = 2
                                                        32 PPM           = 3
                                                        80 PPM           = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  104 +
      |
      | 1                                                            34      2  1
      |                                                              34    4 2  1          2 1
   96 +                                                                    4 3  4  3       221 1
      |                                                                         4  3  3    42 21  1
      |                                                                                       2   12   1
      |                                                                               33   4     4 22  11
   88 +                                                                                3      3  4 4
      |                                                                                       33   42  2
      |                                                                                        3 3  4 421  1
      |                                                                                                 22
P  80 +                                                                                          3 3  44 2 11
E     |                                                                                            3   34  22
R     |                                                                                                     11
C     |                                                                                                33 4 21   1
E  72 +                                                                                                   44 2   11
N     |                                                                                                          211
T     |                                                                                                           211
      |                                                                                                 3 344       22
S  64 +
U     |                                                                                                   33        1    1
R     |                                                                                                    334       2 2 11
V     |                                                                                                     3 3        22 1 1
I  56 +                                                                                                      43  3      2 2
V     |                                                                                                          33       2 1
A     |
L     |                                                                                                       44  33
   48 +
      |                                                                                                        4 4 33
      |                                                                                                             33
      |
   40 +                                                                                                          44
      |                                                                                                           44 3 3
      |
      |                                                                                                            44  33
   32 +                                                                                                             44  33
      |                                                                                                              4 4
      |                                                                                                                  3  3
      |                                                                                                                4    4
   24 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.
                                                            CHLOROPRENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        12.8 PPM         = 2
                                                        32 PPM           = 3
                                                        80 PPM           = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1     1                           3     4    2
      |       1                           3     4    2     24  3                    1
      |                                                    244 3   3 43      22     111
      |                                                              433      2     2 1     1
   90 +                                                                3   3  4 4   2      21 1
      |                                                                    3 3  44         22 1          1
      |                                                                      3  343         2 2          1  1
      |                                                                           33 4        22            1    1
   80 +                                                                            3 3     4                     1 1
      |                                                                              3 3       2        2          11
      |                                                                                33               2 2         1  1
      |                                                                                 33 44             22           1    1
P  70 +                                                                                  3 3               22               1
E     |                                                                                     44
R     |                                                                                    334 4
C     |                                                                                     33 4 4          2      2
E  60 +                                                                                          4 4
N     |                                                                                      33                    22
T     |                                                                                       33   44               22
      |                                                                                        3  3 4  4
S  50 +                                                                                           3 3  444
U     |
R     |                                                                                             3  334 4         22
V     |                                                                                                               22
I  40 +                                                                                                    44          22
V     |                                                                                                 3 3             22
A     |                                                                                                   33
L     |                                                                                                                  2  2
   30 +
      |                                                                                                    334
      |                                                                                                      44
      |                                                                                                     33
   20 +                                                                                                      334
      |                                                                                                       33 4
      |                                                                                                          44
      |                                                                                                        3  34
   10 +
      |                                                                                                           334
      |                                                                                                            343   3  4
      |                                                                                                                  3  3
    0 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 20 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.