TDMS Study 05136-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest CHLOROPRENE DATE: 09/13/96
EXPERIMENT: 05136 TEST: 07 TIME: 16:35:26
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: S. GRUMBEIN CAS: 0000126-99-8
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest CHLOROPRENE DATE: 09/13/96
EXPERIMENT: 05136 TEST: 07 TIME: 16:35:26
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05291 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 50522B
PATHOLOGIST: S. GRUMBEIN CAS: 0000126-99-8
CHLOROPRENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 469 489 525 533 534 536 541 569 569 571 |
| 575 576 580 589 600 604 613 613 616 616 |
| 634 634 637 637 642 646 649 657 658 693 |
| 695 695 695 702 716 716 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12.8 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 41 CENSORED DEATHS 0 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 357 437 497 525 530 534 541 541 544 556 |
| 575 581 581 597 600 603 608 609 613 618 |
| 637 638 645 650 651 663 665 665 665 670 |
| 677 679 689 700 700 701 701 702 706 707 |
| 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 32 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 45 CENSORED DEATHS 0 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 460 460 497 497 505 506 512 523 524 528 |
| 534 534 540 549 561 565 567 568 569 569 |
| 569 584 585 590 595 609 609 620 622 622 |
| 622 637 642 652 665 667 679 681 681 702 |
| 705 707 721 721 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CHLOROPRENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 80 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 46 CENSORED DEATHS 0 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 305 307 463 470 497 522 530 532 533 539 |
| 540 549 558 567 576 578 583 597 601 603 |
| 608 609 611 613 617 625 625 625 628 646 |
| 649 651 651 660 660 663 663 667 672 673 |
| 691 693 702 702 715 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CHLOROPRENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 86.0 68.0 42.0 26.0 |
| | |
| | |
|12.8 PPM | 100.0 100.0 100.0 98.0 98.0 96.0 82.0 68.0 42.0 18.0 |
| | |
| | |
|32 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 74.0 50.0 30.0 10.0 |
| | |
| | |
|80 PPM | 100.0 100.0 100.0 96.0 96.0 92.0 78.0 60.0 26.0 8.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 12.8 PPM 32 PPM 80 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 26.0% 18.0% 10.0% 8.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.013 P=0.615 P=0.025 P=0.025 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 614.8 616.8 595.1 597.8 |
|NATURAL DEATHS (C) | (10.8) (12.5) (11.0) (13.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 645.5 637.7 608.9 608.6 |
|(STANDARD ERROR) | (10.9) (12.0) (11.5) (13.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CHLOROPRENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 366 432 553 573 581 589 600 601 622 644 |
| 651 651 661 665 665 670 687 697 702 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12.8 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 302 352 485 525 565 576 608 630 657 665 |
| 667 671 679 681 681 691 694 707 707 721 |
| 721 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 32 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 450 470 534 540 544 567 585 588 590 597 |
| 597 601 604 608 618 634 646 651 651 679 |
| 691 693 693 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CHLOROPRENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 80 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 433 463 525 553 572 576 589 591 609 611 |
| 613 617 624 624 637 648 649 660 666 667 |
| 671 673 679 705 705 716 720 721 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CHLOROPRENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 95.9 95.9 83.7 69.4 59.2 |
| | |
| | |
|12.8 PPM | 100.0 100.0 100.0 96.0 96.0 94.0 92.0 88.0 80.0 56.0 |
| | |
| | |
|32 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 90.0 74.0 62.0 52.0 |
| | |
| | |
|80 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 84.0 64.0 42.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 12.8 PPM 32 PPM 80 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 59.2% 56.0% 52.0% 42.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.085 P=1.000 P=0.473 P=0.151 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 616.6 623.2 606.3 629.2 |
|NATURAL DEATHS (C) | (19.7) (24.7) (13.9) (13.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 685.5 684.7 672.2 672.8 |
|(STANDARD ERROR) | (11.4) (13.2) (11.2) (10.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CHLOROPRENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
12.8 PPM = 2
32 PPM = 3
80 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 2 31
| 2 2 1 1
| 4 2 344 12 1 1
| 4 3 3 22
90 + 4 422
| 33 4411
| 3 3441 1
| 33 2 2
80 + 334 2 11
| 44
| 33344 1 12
| 3 3 4 11
P 70 + 11
E | 44 11
R | 33 4 422
C | 4422
E 60 + 12 1
N | 3 3 22
T | 3 3 44 22
| 44 11
S 50 + 3 3 44 11 2
U |
R | 3 3 11
V | 4 41 22 1
I 40 + 22 11
V | 3 3
A | 3343 4 2 211
L | 3 3 1 1
30 + 33 22
| 33 11
| 4433 1 1
| 443 3
20 + 4 4 2 2
| 2
| 4 3 3
| 4 33
10 + 43 3
| 4 4
|
|
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 28 obs hidden.
CHLOROPRENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
12.8 PPM = 2
32 PPM = 3
80 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 4 3
| 2 2 1 1 3 43
| 2 1 43 2 2 331 1
| 2 4 211
P 90 + 3 241 1
E | 3 23 112
R | 3 3 2 2 2
C | 31441 1 2 2
E 80 + 11 22
N | 44
T | 33 44 1 1222
| 3 344
S 70 + 3 3 4 11 22
U | 3 3 1 12
R | 4 44 112
V | 3 3 11 2
I 60 + 3 3 1 1 1
V | 44 22
A | 4 3 4 32 2
L | 3 3
50 + 4 4
|
| 4 4
| 4
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 28 obs hidden.