National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2990

TDMS Study 05142-04 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          T-BUTYL ALCOHOL


NTP Experiment-Test: 05142-04                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: DOSED WATER                                                                                                Time: 08:27:30




       Facility:  Southern Research Institute

       Chemical CAS #:  75-65-0

       Lock Date:  01/23/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           14           13           12                                     
    Natural Death                                     10            8            4            4                                     
    Accidently Killed                                  1            3            2            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           35           40           42                                     
    Natural Death                                                                1                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (58)         (59)         (58)         (56)                                   
      Mucosa, Hyperplasia                                           1 (2%)       1 (2%)                                             
   Intestine Small, Duodenum                          (58)         (57)         (56)         (60)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Perforation                                                                1 (2%)                                             
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (57)         (56)         (57)         (60)                                   
      Developmental Malformation                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                                                                   2 (3%)                                
   Liver                                              (59)         (60)         (59)         (60)                                   
      Basophilic Focus                                 3 (5%)       1 (2%)                    2 (3%)                                
      Clear Cell Focus                                              5 (8%)       3 (5%)                                             
      Eosinophilic Focus                              13 (22%)     14 (23%)     16 (27%)     20 (33%)                               
      Fatty Change                                    11 (19%)      8 (13%)      8 (14%)      6 (10%)                               
      Fibrosis, Focal                                  1 (2%)       1 (2%)       1 (2%)                                             
      Focal Cellular Change                                                                   1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                    5 (8%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Infarct                                          1 (2%)       2 (3%)       2 (3%)                                             
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Inflammation, Focal                              5 (8%)       2 (3%)       7 (12%)      3 (5%)                                
      Mineralization, Focal                            1 (2%)                                                                       
      Mixed Cell Focus                                 2 (3%)       5 (8%)       7 (12%)      4 (7%)                                
      Necrosis                                                                   1 (2%)                                             
      Necrosis, Focal                                  2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Pigmentation                                     1 (2%)       3 (5%)       3 (5%)                                             
      Tension Lipidosis                                             1 (2%)       1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Hyperplasia                                                     1 (2%)                                             
      Centrilobular, Atrophy                                        1 (2%)                                                          
      Centrilobular, Fibrosis                                                    1 (2%)       1 (2%)                                
      Centrilobular, Necrosis                          2 (3%)                    2 (3%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (24)         (17)         (17)         (12)                                   
      Cyst                                                                       1 (6%)                                             
      Hemorrhage                                       1 (4%)       1 (6%)                                                          
      Inflammation, Chronic                            2 (8%)       2 (12%)      1 (6%)                                             
      Fat, Necrosis                                   14 (58%)     10 (59%)     12 (71%)      4 (33%)                               
   Pancreas                                           (59)         (59)         (59)         (59)                                   
      Atrophy, Focal                                   3 (5%)       3 (5%)       1 (2%)                                             
      Acinar Cell, Focal Cellular Change                            1 (2%)                                                          
      Duct, Dilatation                                              2 (3%)       1 (2%)                                             
   Stomach, Forestomach                               (60)         (60)         (59)         (60)                                   
      Cyst                                                                                    1 (2%)                                
      Erosion                                          1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            4 (7%)       2 (3%)       1 (2%)       1 (2%)                                
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            2 (3%)                    1 (2%)       1 (2%)                                
      Mucosa, Hyperplasia                              3 (5%)       5 (8%)       5 (8%)       4 (7%)                                
   Stomach, Glandular                                 (60)         (60)         (59)         (59)                                   
      Angiectasis                                                                             1 (2%)                                
      Erosion                                                       1 (2%)       1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Pigmentation                                     1 (2%)                    1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Hyperplasia                              2 (3%)                                                                       
   Tooth                                              (3)          (2)          (1)          (3)                                    
      Incisor, Dysplasia                               3 (100%)     2 (100%)     1 (100%)     3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Aorta, Bacterium                                                           1 (100%)                                           
      Aorta, Inflammation, Focal, Suppurative                                    1 (100%)                                           
      Aorta, Thrombosis                                                          1 (100%)                                           
   Heart                                              (60)         (60)         (60)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Mineralization, Focal                                         1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)                                                          
      Focal Cellular Change                            2 (3%)                    3 (5%)                                             
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Subcapsular, Hyperplasia, Focal                               3 (5%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)                                                          
   Parathyroid Gland                                  (48)         (56)         (57)         (50)                                   
      Cyst                                                                       1 (2%)                                             
   Pituitary Gland                                    (56)         (57)         (60)         (60)                                   
      Angiectasis                                      1 (2%)       2 (4%)                    1 (2%)                                
      Cyst                                                          1 (2%)       1 (2%)       1 (2%)                                
      Hemorrhage                                                                              2 (3%)                                
      Pars Distalis, Focal Cellular Change             6 (11%)      6 (11%)      6 (10%)      2 (3%)                                
      Pars Distalis, Hyperplasia, Focal                1 (2%)       5 (9%)       5 (8%)       1 (2%)                                
   Thyroid Gland                                      (58)         (60)         (59)         (59)                                   
      Degeneration, Cystic                             8 (14%)      9 (15%)      9 (15%)      4 (7%)                                
      Inflammation, Focal                              1 (2%)                                 1 (2%)                                
      C-Cell, Hyperplasia                              2 (3%)                                                                       
      Follicle, Cyst                                                1 (2%)       1 (2%)                                             
      Follicular Cell, Cyst                                         1 (2%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                    19 (33%)     28 (47%)     33 (56%)     47 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)          (2)          (2)          (1)                                    
      Degeneration, Cystic                             1 (100%)     2 (100%)     1 (50%)      1 (100%)                              
   Ovary                                              (58)         (58)         (60)         (59)                                   
      Angiectasis                                      1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Hemorrhage                                       3 (5%)       1 (2%)       2 (3%)                                             
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                 1 (2%)                                
      Follicle, Cyst                                  15 (26%)     13 (22%)     17 (28%)     12 (20%)                               
      Periovarian Tissue, Hemorrhage                                                          1 (2%)                                
   Uterus                                             (60)         (60)         (59)         (59)                                   
      Angiectasis                                      1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Atrophy                                          1 (2%)                                                                       
      Decidual Reaction                                             1 (2%)                                                          
      Exudate                                          1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hydrometra                                      20 (33%)     25 (42%)     19 (32%)     27 (46%)                               
      Inflammation, Suppurative                        4 (7%)       1 (2%)       1 (2%)       3 (5%)                                
      Endometrium, Hyperplasia, Cystic                58 (97%)     59 (98%)     58 (98%)     56 (95%)                               
      Lymphatic, Ectasia                                            1 (2%)                                                          
   Vagina                                                          (1)                                                              
      Epithelium, Metaplasia                                        1 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hypercellularity                                              1 (2%)                                                          
   Lymph Node                                         (19)         (12)         (6)          (13)                                   
      Bronchial, Hyperplasia, Lymphoid                 1 (5%)                                                                       
      Iliac, Angiectasis                               1 (5%)                                 1 (8%)                                
      Iliac, Hematopoietic Cell Proliferation          1 (5%)                                                                       
      Iliac, Hyperplasia                               1 (5%)       1 (8%)                    1 (8%)                                
      Inguinal, Hyperplasia, Lymphoid                                            1 (17%)      1 (8%)                                
      Inguinal, Hyperplasia, Mast Cell                                                        1 (8%)                                
      Mediastinal, Angiectasis                         1 (5%)       1 (8%)                                                          
      Mediastinal, Hyperplasia                                                   2 (33%)                                            
      Mediastinal, Hyperplasia, Lymphoid               3 (16%)                                                                      
      Renal, Hematopoietic Cell Proliferation          1 (5%)                                                                       
      Renal, Hyperplasia                               1 (5%)                                 1 (8%)                                
   Lymph Node, Mandibular                             (59)         (58)         (59)         (57)                                   
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       2 (3%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (56)         (59)         (57)         (57)                                   
      Angiectasis                                                                2 (4%)       2 (4%)                                
      Hematopoietic Cell Proliferation                              1 (2%)                    1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Lymphoid                            8 (14%)     10 (17%)      4 (7%)       4 (7%)                                
      Hyperplasia, Macrophage                          1 (2%)                                                                       
   Spleen                                             (59)         (60)         (59)         (59)                                   
      Depletion Cellular                               3 (5%)       2 (3%)                    1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                27 (46%)     25 (42%)     28 (47%)     20 (34%)                               
      Hyperplasia, Lymphoid                           15 (25%)     18 (30%)     13 (22%)     18 (31%)                               
      Pigmentation                                                                            1 (2%)                                
   Thymus                                             (57)         (58)         (53)         (58)                                   
      Congestion                                       1 (2%)                                                                       
      Cyst                                             2 (4%)                                                                       
      Hyperplasia, Lymphoid                            3 (5%)       5 (9%)       3 (6%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Dilatation                                                    4 (7%)       4 (7%)       3 (5%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic, Focal                     1 (2%)       1 (2%)       1 (2%)       3 (5%)                                
      Ulcer                                                                      1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Epidermis, Hyperplasia, Focal                    1 (2%)                                                                       
      Sebaceous Gland, Hyperplasia                     1 (2%)                                                                       
      Subcutaneous Tissue, Edema                       2 (3%)       2 (3%)                                                          
      Subcutaneous Tissue, Hyperplasia, Mast Cell                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fibrous Osteodystrophy                          30 (50%)     34 (57%)     34 (57%)     23 (38%)                               
      Hyperostosis                                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                      1 (2%)       3 (5%)       6 (10%)      2 (3%)                                
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Hemorrhage                                       2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)       2 (3%)                    3 (5%)                                
      Foreign Body                                                                            3 (5%)                                
      Hemorrhage                                       1 (2%)                                 4 (7%)                                
      Hyperplasia, Macrophage                          1 (2%)       1 (2%)       2 (3%)       2 (3%)                                
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              3 (5%)                    2 (3%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Foreign Body                                                                            1 (2%)                                
      Inflammation, Suppurative                        4 (7%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (1)                                    
      Pinna, Inflammation, Chronic, Focal                           1 (100%)                                                        
      Pinna, Ulcer                                                  1 (100%)                                                        
   Eye                                                                                       (1)                                    
      Atrophy                                                                                 1 (100%)                              
      Inflammation, Chronic                                                                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (59)         (60)                                   
      Cyst                                                          1 (2%)                                                          
      Inflammation, Suppurative                                                               1 (2%)                                
      Metaplasia, Osseous                                                        2 (3%)       2 (3%)                                
      Nephropathy                                     40 (68%)     37 (62%)     36 (61%)     31 (52%)                               
      Pelvis, Dilatation                                            1 (2%)       2 (3%)                                             
      Renal Tubule, Degeneration, Hyaline              1 (2%)                                                                       
      Renal Tubule, Vacuolization Cytoplasmic                       1 (2%)                                                          
   Urinary Bladder                                    (59)         (60)         (59)         (57)                                   
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                                                                   4 (7%)                                
      Transitional Epithelium, Hyperplasia                                                    3 (5%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           14           19           21                                     
    Natural Death                                     13            8            6           22                                     
    Accidently Killed                                               2            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           36           34           17                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Inflammation, Focal, Suppurative                                                        1 (2%)                                
   Gallbladder                                        (55)         (57)         (59)         (54)                                   
      Cyst                                             1 (2%)                                                                       
   Intestine Small, Duodenum                          (56)         (56)         (57)         (56)                                   
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (56)         (56)         (57)         (55)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Ileum                             (56)         (56)         (57)         (55)                                   
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
   Liver                                              (59)         (60)         (59)         (59)                                   
      Angiectasis                                                   3 (5%)       1 (2%)                                             
      Basophilic Focus                                 2 (3%)       8 (13%)     10 (17%)      6 (10%)                               
      Clear Cell Focus                                10 (17%)     25 (42%)     21 (36%)     20 (34%)                               
      Congestion                                                                 1 (2%)                                             
      Eosinophilic Focus                              20 (34%)     24 (40%)     31 (53%)     10 (17%)                               
      Fatty Change                                    12 (20%)      5 (8%)       8 (14%)     29 (49%)                               
      Fibrosis, Focal                                               1 (2%)                                                          
      Focal Cellular Change                                                                   2 (3%)                                
      Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)                                                          
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Infarct                                          2 (3%)       1 (2%)       2 (3%)                                             
      Infiltration Cellular, Mixed Cell                                          1 (2%)                                             
      Inflammation, Focal                              2 (3%)                    3 (5%)                                             
      Mixed Cell Focus                                 4 (7%)       4 (7%)       3 (5%)       5 (8%)                                
      Necrosis, Focal                                  5 (8%)       3 (5%)       5 (8%)       1 (2%)                                
      Tension Lipidosis                                                                       5 (8%)                                
      Thrombosis                                                                 1 (2%)                                             
      Centrilobular, Necrosis                                       1 (2%)       1 (2%)       1 (2%)                                
   Mesentery                                          (5)          (6)          (7)          (4)                                    
      Angiectasis                                                                             1 (25%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cyst                                                                       1 (14%)                                            
      Hemorrhage                                       1 (20%)                                                                      
      Hyperplasia, Mast Cell                                        1 (17%)                                                         
      Inflammation, Chronic                            1 (20%)                   2 (29%)      1 (25%)                               
      Mineralization                                   1 (20%)                                                                      
      Fat, Necrosis                                    1 (20%)      3 (50%)      3 (43%)      2 (50%)                               
   Pancreas                                           (58)         (59)         (59)         (57)                                   
      Atrophy, Focal                                   3 (5%)       2 (3%)       1 (2%)                                             
      Edema                                            1 (2%)                    1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
      Duct, Dilatation                                              1 (2%)                                                          
   Stomach, Forestomach                               (59)         (59)         (59)         (58)                                   
      Erosion                                                       2 (3%)                                                          
      Inflammation, Chronic                            6 (10%)      4 (7%)       1 (2%)       7 (12%)                               
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)       4 (7%)                                
      Mucosa, Hyperplasia                              7 (12%)      7 (12%)      1 (2%)       4 (7%)                                
   Stomach, Glandular                                 (59)         (59)         (59)         (57)                                   
      Erosion                                                       1 (2%)                    3 (5%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                   1 (2%)                                 2 (4%)                                
      Pigmentation                                     1 (2%)       3 (5%)                    2 (4%)                                
      Mucosa, Hyperplasia                              4 (7%)                                 2 (4%)                                
   Tooth                                              (44)         (41)         (33)         (26)                                   
      Incisor, Dysplasia                              44 (100%)    41 (100%)    33 (100%)    26 (100%)                              
      Incisor, Inflammation, Suppurative                                         1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (1)                                                              
      Mesenteric Artery, Inflammation, Chronic         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule                             1 (2%)                    2 (3%)                                
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                                             
      Focal Cellular Change                            2 (3%)       6 (10%)      1 (2%)       1 (2%)                                
      Subcapsular, Hyperplasia, Focal                  5 (8%)       7 (12%)      7 (12%)      1 (2%)                                
   Parathyroid Gland                                  (55)         (59)         (56)         (55)                                   
      Cyst                                             2 (4%)                                 2 (4%)                                
      Degeneration, Cystic                                          1 (2%)                                                          
   Pituitary Gland                                    (52)         (57)         (56)         (53)                                   
      Cyst                                             2 (4%)       1 (2%)                    3 (6%)                                
      Pars Distalis, Focal Cellular Change             1 (2%)                                                                       
   Thyroid Gland                                      (60)         (59)         (59)         (57)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                             7 (12%)      5 (8%)      10 (17%)      5 (9%)                                
      Inflammation, Focal                                                        1 (2%)                                             
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     5 (8%)      18 (31%)     15 (25%)     18 (32%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (23)         (13)         (21)         (4)                                    
      Dilatation                                      23 (100%)    13 (100%)    21 (100%)     4 (100%)                              
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Granuloma Sperm                                  4 (7%)       1 (2%)       2 (3%)       3 (5%)                                
      Inflammation, Chronic                                                      3 (5%)       1 (2%)                                
   Penis                                                           (1)                                                              
      Inflammation, Chronic                                         1 (100%)                                                        
      Necrosis                                                      1 (100%)                                                        
   Preputial Gland                                    (27)         (36)         (24)         (21)                                   
      Degeneration, Cystic                            26 (96%)     33 (92%)     23 (96%)     21 (100%)                              
      Inflammation, Chronic                            2 (7%)       5 (14%)      1 (4%)       1 (5%)                                
   Prostate                                           (60)         (60)         (60)         (58)                                   
      Dilatation                                       2 (3%)       1 (2%)       2 (3%)                                             
      Inflammation, Chronic                                         2 (3%)       2 (3%)       1 (2%)                                
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
      Congestion                                                                              1 (2%)                                
      Dilatation                                      35 (58%)     31 (52%)     36 (60%)     11 (18%)                               
      Hemorrhage                                       2 (3%)       3 (5%)       1 (2%)       2 (3%)                                
      Inflammation, Chronic                                                      2 (3%)                                             
   Testes                                             (60)         (60)         (60)         (59)                                   
      Angiectasis                                      1 (2%)                                                                       
      Degeneration                                                                            1 (2%)                                
      Granuloma Sperm                                  1 (2%)                                                                       
      Mineralization                                                             1 (2%)       1 (2%)                                
      Germinal Epithelium, Degeneration                2 (3%)                                 6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Hypercellularity                                 2 (3%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Myelofibrosis, Focal                                          1 (2%)                                                          
   Lymph Node                                         (9)          (5)          (1)          (1)                                    
      Angiectasis                                      1 (11%)                   1 (100%)                                           
      Inguinal, Cyst                                                                          1 (100%)                              
      Inguinal, Hyperplasia                                         1 (20%)                                                         
      Inguinal, Hyperplasia, Lymphoid                               2 (40%)                                                         
      Mediastinal, Hyperplasia                         3 (33%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 (11%)                                                                      
      Pancreatic, Hyperplasia                                       1 (20%)                                                         
      Renal, Hyperplasia                               1 (11%)      1 (20%)                                                         
   Lymph Node, Mandibular                             (57)         (59)         (58)         (56)                                   
      Hyperplasia                                      2 (4%)                    2 (3%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (59)         (58)         (57)         (56)                                   
      Angiectasis                                     13 (22%)     23 (40%)     17 (30%)     13 (23%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       4 (7%)       4 (7%)                                             
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                           10 (17%)      6 (10%)      9 (16%)      8 (14%)                               
   Spleen                                             (59)         (59)         (59)         (57)                                   
      Depletion Cellular                               2 (3%)       6 (10%)      5 (8%)      25 (44%)                               
      Fibrosis                                         1 (2%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                21 (36%)     14 (24%)     14 (24%)     11 (19%)                               
      Hyperplasia, Lymphoid                            7 (12%)     12 (20%)      8 (14%)      7 (12%)                               
   Thymus                                             (53)         (54)         (55)         (52)                                   
      Cyst                                             9 (17%)      3 (6%)       7 (13%)      5 (10%)                               
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Epithelial Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic, Focal                     1 (2%)       2 (3%)       2 (3%)                                             
      Ulcer                                                         1 (2%)                                                          
      Epidermis, Hyperplasia, Focal                                 1 (2%)       1 (2%)                                             
      Hair Follicle, Atrophy                                                                  1 (2%)                                
      Subcutaneous Tissue, Abscess                     1 (2%)                                                                       
      Subcutaneous Tissue, Edema                       1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Hemorrhage                  1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Hyperostosis                                                                            2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)       1 (2%)       5 (8%)                                
      Foreign Body                                                  1 (2%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)                    1 (2%)                                
      Hyperplasia, Macrophage                          4 (7%)       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Mixed Cell                1 (2%)       2 (3%)                                                          
      Inflammation, Acute, Focal                                                              1 (2%)                                
      Inflammation, Chronic, Focal                     2 (3%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 4 (7%)       4 (7%)       2 (3%)       1 (2%)                                
      Artery, Thrombosis                               1 (2%)                                                                       
      Bronchus, Epithelium, Hyperplasia                             1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (59)                                   
      Inflammation, Suppurative                        1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)                                                 
      Inflammation, Chronic                            1 (50%)                                                                      
   Harderian Gland                                    (10)         (3)          (3)          (1)                                    
      Inflammation, Chronic                            1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (58)         (59)         (57)                                   
      Atrophy, Focal                                                                          1 (2%)                                
      Congestion                                                    1 (2%)                    4 (7%)                                
      Cyst                                             7 (12%)      4 (7%)       3 (5%)       1 (2%)                                
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Nephropathy                                     51 (85%)     54 (93%)     55 (93%)     44 (77%)                               
      Artery, Inflammation, Chronic                                              1 (2%)       1 (2%)                                
      Pelvis, Dilatation                               3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
      Renal Tubule, Degeneration, Hyaline              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05142-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Dilatation                         2 (3%)                    1 (2%)       3 (5%)                                
   Ureter                                                                                    (1)                                    
      Dilatation                                                                              1 (100%)                              
   Urethra                                            (1)          (2)                       (3)                                    
      Angiectasis                                                   1 (50%)                                                         
      Dilatation                                                    1 (50%)                   1 (33%)                               
      Inflammation, Acute                                           1 (50%)                                                         
      Inflammation, Chronic                            1 (100%)                               2 (67%)                               
      Bulbourethral Gland, Angiectasis                              1 (50%)                                                         
   Urinary Bladder                                    (59)         (59)         (58)         (59)                                   
      Calculus Gross Observation, Multiple,                                                                                         
          Greater Than Five                                                                   1 (2%)                                
      Dilatation                                       3 (5%)       2 (3%)       2 (3%)       2 (3%)                                
      Inflammation, Chronic                                         3 (5%)       1 (2%)      37 (63%)                               
      Artery, Inflammation, Chronic                                                           1 (2%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)       3 (5%)       1 (2%)      17 (29%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.