National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2994

TDMS Study 05142-04 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          T-BUTYL ALCOHOL


NTP Experiment-Test: 05142-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: DOSED WATER                                                                                                Time: 08:27:30




       Facility:  Southern Research Institute

       Chemical CAS #:  75-65-0

       Lock Date:  01/23/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           14           13           12                                     
    Natural Death                                     10            8            4            4                                     
    Accidently Killed                                  1            3            2            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           35           40           42                                     
    Natural Death                                                                1                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
   Gallbladder                                        (58)         (59)         (58)         (56)                                   
   Intestine Large, Colon                             (57)         (58)         (58)         (60)                                   
   Intestine Small, Duodenum                          (58)         (57)         (56)         (60)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (57)         (56)         (57)         (60)                                   
      Adenocarcinoma                                   2 (4%)                                                                       
   Intestine Small, Ileum                             (57)         (57)         (55)         (60)                                   
      Adenocarcinoma                                                             1 (2%)                                             
   Liver                                              (59)         (60)         (59)         (60)                                   
      Cholangiocarcinoma                               1 (2%)       1 (2%)                    1 (2%)                                
      Hemangiosarcoma                                  2 (3%)                                                                       
      Hepatocellular Carcinoma                        16 (27%)     18 (30%)     12 (20%)      8 (13%)                               
      Hepatocellular Carcinoma, Multiple               9 (15%)      8 (13%)     10 (17%)      4 (7%)                                
      Hepatocellular Adenoma                          17 (29%)     17 (28%)     16 (27%)     14 (23%)                               
      Hepatocellular Adenoma, Multiple                12 (20%)     13 (22%)     15 (25%)     15 (25%)                               
      Hepatocholangiocarcinoma                                      1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    3 (5%)                                
   Mesentery                                          (24)         (17)         (17)         (12)                                   
      Cholangiocarcinoma, Metastatic, Liver            1 (4%)       1 (6%)                    1 (8%)                                
      Fibrosarcoma                                                  1 (6%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (6%)                                             
      Histiocytic Sarcoma                              1 (4%)                                 3 (25%)                               
   Pancreas                                           (59)         (59)         (59)         (59)                                   
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Hemangioma                                                                              1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                                                     2 (3%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (59)         (60)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                                       1 (2%)       2 (3%)       2 (3%)                                
   Stomach, Glandular                                 (60)         (60)         (59)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Subcapsular, Adenoma                                          1 (2%)       1 (2%)                                             
      Subcapsular, Carcinoma                                        1 (2%)                                                          
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                                                    2 (3%)                                             
   Islets, Pancreatic                                 (59)         (59)         (59)         (59)                                   
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Carcinoma                                                                               1 (2%)                                
   Parathyroid Gland                                  (48)         (56)         (57)         (50)                                   
   Pituitary Gland                                    (56)         (57)         (60)         (60)                                   
      Pars Distalis, Adenoma                          11 (20%)     18 (32%)     15 (25%)     18 (30%)                               
   Thyroid Gland                                      (58)         (60)         (59)         (59)                                   
      Bilateral, Follicular Cell, Adenoma                                                     1 (2%)                                
      C-Cell, Adenoma                                                                         1 (2%)                                
      Follicular Cell, Adenoma                         2 (3%)       3 (5%)       2 (3%)       8 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (58)         (58)         (60)         (59)                                   
      Cystadenoma                                      2 (3%)                    3 (5%)       3 (5%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Luteoma                                          1 (2%)                                                                       
      Teratoma Benign                                                            1 (2%)                                             
      Teratoma NOS                                                               1 (2%)                                             
   Uterus                                             (60)         (60)         (59)         (59)                                   
      Granular Cell Tumor Malignant                                                           1 (2%)                                
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Leiomyoma                                                                  1 (2%)                                             
      Endometrium, Polyp Stromal                       1 (2%)                    1 (2%)       1 (2%)                                
      Endometrium, Polyp Stromal, Multiple, Two                                               1 (2%)                                
      Endometrium, Sarcoma Stromal                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                 2 (3%)                                
   Lymph Node                                         (19)         (12)         (6)          (13)                                   
      Bronchial, Cholangiocarcinoma, Metastatic,                                                                                    
           Liver                                       1 (5%)                                                                       
      Iliac, Histiocytic Sarcoma                                                              1 (8%)                                
      Mediastinal, Cholangiocarcinoma, Metastatic,                                                                                  
           Liver                                       1 (5%)       1 (8%)                    1 (8%)                                
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                         1 (8%)                                                          
      Mediastinal, Histiocytic Sarcoma                              1 (8%)                    1 (8%)                                
      Pancreatic, Histiocytic Sarcoma                                                         1 (8%)                                
      Renal, Hemangiosarcoma                                        1 (8%)       1 (17%)                                            
      Renal, Histiocytic Sarcoma                                                              1 (8%)                                
   Lymph Node, Mandibular                             (59)         (58)         (59)         (57)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (56)         (59)         (57)         (57)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    2 (4%)                                
   Spleen                                             (59)         (60)         (59)         (59)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    3 (5%)                                
   Thymus                                             (57)         (58)         (53)         (58)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Thymocyte, Thymoma Benign                                     1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Adenocarcinoma                                                                          1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                    2 (3%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)          (1)          (2)                                    
      Cholangiocarcinoma, Metastatic, Liver            1 (50%)      1 (100%)                  1 (50%)                               
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (100%)                                           
      Histiocytic Sarcoma                                                                     1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Meningioma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     2 (3%)       3 (5%)       5 (8%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (3%)       2 (3%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple, Two    1 (2%)                                 1 (2%)                                
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)       1 (2%)                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      4 (7%)       3 (5%)       5 (8%)       1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                 2 (3%)                                
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)       1 (2%)                                             
   Nose                                               (60)         (60)         (60)         (60)                                   
      Submucosa, Hemangioma                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (1)                                    
      Pinna, Hemangioma                                                                       1 (100%)                              
   Harderian Gland                                    (3)          (1)          (1)          (2)                                    
      Adenoma                                          1 (33%)      1 (100%)     1 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (60)         (59)         (60)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (59)         (60)         (59)         (57)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
                                                             Page   5                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              3 (5%)       1 (2%)                    3 (5%)                                
      Lymphoma Malignant Lymphocytic                   2 (3%)                                                                       
      Lymphoma Malignant Mixed                        15 (25%)     22 (37%)     21 (35%)     14 (23%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            54          54          55          53                                       
     Total Primary Neoplasms                          107         120         115         111                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38          40          44          45                                       
     Total Benign Neoplasms                            50          61          65          73                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              41          45          40          31                                       
     Total Malignant Neoplasms                         57          59          49          38                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           5           6           2                                       
     Total Metastatic Neoplasm                         10          13          14           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           14           19           21                                     
    Natural Death                                     13            8            6           22                                     
    Accidently Killed                                               2            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           36           34           17                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (55)         (57)         (59)         (54)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Small, Duodenum                          (56)         (56)         (57)         (56)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Jejunum                           (56)         (56)         (57)         (55)                                   
      Adenocarcinoma                                   1 (2%)                    2 (4%)                                             
      Hemangioma                                                    1 (2%)                                                          
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Ileum                             (56)         (56)         (57)         (55)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Liver                                              (59)         (60)         (59)         (59)                                   
      Cholangiocarcinoma                               1 (2%)       1 (2%)                                                          
      Hemangioma                                                    2 (3%)                                                          
      Hemangiosarcoma                                  3 (5%)       5 (8%)       2 (3%)                                             
      Hepatoblastoma                                   2 (3%)       2 (3%)       4 (7%)       2 (3%)                                
      Hepatoblastoma, Multiple                                                                1 (2%)                                
      Hepatocellular Carcinoma                        14 (24%)     14 (23%)     21 (36%)     14 (24%)                               
      Hepatocellular Carcinoma, Multiple              11 (19%)     15 (25%)     14 (24%)      5 (8%)                                
      Hepatocellular Adenoma                          18 (31%)     15 (25%)     22 (37%)     13 (22%)                               
      Hepatocellular Adenoma, Multiple                21 (36%)     26 (43%)     22 (37%)     13 (22%)                               
      Hepatocellular Adenoma, Multiple, Two            1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (3%)                    1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
   Mesentery                                          (5)          (6)          (7)          (4)                                    
      Hemangiosarcoma                                               1 (17%)                                                         
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (17%)                                                         
      Histiocytic Sarcoma                              1 (20%)                   1 (14%)                                            
      Sarcoma                                          1 (20%)                                                                      
   Pancreas                                           (58)         (59)         (59)         (57)                                   
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
   Stomach, Forestomach                               (59)         (59)         (59)         (58)                                   
                                                             Page   8                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       2 (3%)                                                          
   Stomach, Glandular                                 (59)         (59)         (59)         (57)                                   
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Pericardium, Cholangiocarcinoma, Metastatic,                                                                                  
           Liver                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                    2 (3%)                                             
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
      Subcapsular, Adenoma                             3 (5%)       5 (8%)                    2 (3%)                                
   Islets, Pancreatic                                 (59)         (59)         (59)         (57)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (52)         (57)         (56)         (53)                                   
      Pars Distalis, Adenoma                                        1 (2%)                                                          
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (60)         (59)         (59)         (57)                                   
      Follicular Cell, Adenoma                         1 (2%)                    4 (7%)       1 (2%)                                
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                                                              
      Thoracic, Alveolar/Bronchiolar Carcinoma,                                                                                     
           Metastatic, Lung                            1 (100%)                                                                     
      Thoracic, Sarcoma                                             1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                                        2 (3%)                                             
   Testes                                             (60)         (60)         (60)         (59)                                   
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (9)          (5)          (1)          (1)                                    
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (11%)                                                                      
      Mediastinal, Cholangiocarcinoma, Metastatic,                                                                                  
           Liver                                                    1 (20%)                                                         
      Mediastinal, Histiocytic Sarcoma                 1 (11%)                                                                      
      Renal, Histiocytic Sarcoma                       1 (11%)                                                                      
   Lymph Node, Mandibular                             (57)         (59)         (58)         (56)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (59)         (58)         (57)         (56)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (2%)                                                                       
   Spleen                                             (59)         (59)         (59)         (57)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              2 (3%)       1 (2%)                                                          
   Thymus                                             (53)         (54)         (55)         (52)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Thymocyte, Thymoma Malignant                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                               2 (3%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteoma                                          1 (2%)                                                                       
   Skeletal Muscle                                    (2)                                    (1)                                    
      Hemangiosarcoma                                                                         1 (100%)                              
      Sarcoma, Metastatic, Mesentery                   1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                             Page  10                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                    10 (17%)      6 (10%)      6 (10%)      4 (7%)                                
      Alveolar/Bronchiolar Adenoma, Multiple, Two      2 (3%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   4 (7%)       2 (3%)       3 (5%)       2 (3%)                                
      Carcinoma                                                                               1 (2%)                                
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                                                       1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      4 (7%)       3 (5%)       2 (3%)       3 (5%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                                                                       
      Mediastinum, Hemangiosarcoma                     1 (2%)                                                                       
      Pleura, Cholangiocarcinoma, Metastatic, Liver                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (2)                                                 
      Pinna, Fibrosarcoma                                                        1 (50%)                                            
   Harderian Gland                                    (10)         (3)          (3)          (1)                                    
      Adenoma                                          8 (80%)      3 (100%)     2 (67%)      1 (100%)                              
      Carcinoma                                        2 (20%)                   1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (58)         (59)         (57)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Renal Tubule, Adenocarcinoma                                  1 (2%)                    1 (2%)                                
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (59)         (59)         (58)         (59)                                   
      Hemangioma                                                    1 (2%)       1 (2%)                                             
                                                             Page  11                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Histiocytic Sarcoma                              1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              2 (3%)       1 (2%)       2 (3%)                                             
      Lymphoma Malignant Mixed                         7 (12%)      2 (3%)       5 (8%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05142-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 08:27:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            56          56          56          43                                       
     Total Primary Neoplasms                          123         118         119          68                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          49          50          31                                       
     Total Benign Neoplasms                            69          67          62          36                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              41          40          43          27                                       
     Total Malignant Neoplasms                         54          51          57          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              8           4           2           4                                       
     Total Metastatic Neoplasm                         20           7           2           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.