National Toxicology Program

National Toxicology Program
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TDMS Study 05142-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  T-BUTYL ALCOHOL                                   DATE: 05/20/95       
EXPERIMENT: 05142 TEST: 04                                                                                     TIME: 08:42:58       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55121                              ROUTE: DOSED WATER                                             NTP C#: 55367B       
PATHOLOGIST: DR. FARNELL                                                                                       CAS: 75-65-0         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  T-BUTYL ALCOHOL                                   DATE: 05/20/95       
EXPERIMENT: 05142 TEST: 04                                                                                     TIME: 08:42:58       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55121                              ROUTE: DOSED WATER                                             NTP C#: 55367B       
PATHOLOGIST: DR. FARNELL                                                                                       CAS: 75-65-0         


                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  T-BUTYL ALCOHOL                                   DATE: 05/20/95       
EXPERIMENT: 05142 TEST: 04                                                                                     TIME: 08:42:58       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55121                              ROUTE: DOSED WATER                                             NTP C#: 55367B       
PATHOLOGIST: DR. FARNELL                                                                                       CAS: 75-65-0         


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                        IN THE ANALYSIS OF THE STUDY OF T-BUTYL ALCOHOL
              ====================================================================================================
                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Harderian Gland               Adenoma
                                            Carcinoma or Adenoma
              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              All Organs                    Hemangioma
                                            Hemangiosarcoma or Hemangioma
                                            Malignant Lymphoma And Histiocytic Sarcoma
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Liver                         Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatoblastoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Thyroid Gland: Follicular Cell
                                            Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Hemangioma
                                            Hemangiosarcoma
                                            Malignant Tumors
              ====================================================================================================
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE   1
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    5/60 (8%)    2/60 (3%)    2/60 (3%)  |  0/60 (0%)    1/60 (2%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |  13.7%        12.2%         5.9%         9.1%      |   0.0%         2.9%         2.4%         0.0%      |
|TERMINAL (d)           |  3/27 (11%)   2/36 (6%)    2/34 (6%)    1/17 (6%)  |  0/36 (0%)    1/35 (3%)    1/41 (2%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   707          706          728 (T)      628       |   ---          729 (T)      729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.356N     P=0.592N     P=0.240N     P=0.566N   |  P=0.556N     P=0.494      P=0.526        (e)      |
|INCIDENTAL TUMOR       |  P=0.355N     P=0.460      P=0.277N     P=0.523N   |  P=0.556N     P=0.494      P=0.526        (e)      |
|LOGISTIC REGRESSION    |  P=0.344N     P=0.619      P=0.248N     P=0.545N   |  P=0.556N     P=0.494      P=0.526        (e)      |
|COCHRAN-ARMITAGE       |  P=0.180N                                          |  P=0.595N                                          |
|FISHER EXACT           |               P=0.500      P=0.340N     P=0.340N   |               P=0.500      P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         4.9%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/36 (0%)    0/34 (0%)    0/17 (0%)  |  0/36 (0%)    0/35 (0%)    2/41 (5%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.630        (e)        P=0.267        (e)      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.630        (e)        P=0.267        (e)      |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.630        (e)        P=0.267        (e)      |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.595                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)        P=0.248        (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE   2
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/60 (13%)   3/60 (5%)    2/60 (3%)    1/60 (2%)  |  1/60 (2%)    1/60 (2%)    1/60 (2%)    2/60 (3%)  |
|ADJUSTED (b)           |  21.3%         7.6%         5.6%         2.3%      |   2.8%         2.7%         2.4%         4.8%      |
|TERMINAL (d)           |  3/27 (11%)   2/36 (6%)    1/34 (3%)    0/17 (0%)  |  1/36 (3%)    0/35 (0%)    1/41 (2%)    2/42 (5%)  |
|FIRST INCIDENCE (DAYS) |   461          702          727          486       |   729 (T)      727          729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.027N*    P=0.057N     P=0.032N*    P=0.079N   |  P=0.410      P=0.754      P=0.733N     P=0.554    |
|INCIDENTAL TUMOR       |  P=0.019N*    P=0.142N     P=0.070N     P=0.038N*  |  P=0.403      P=0.754N     P=0.733N     P=0.554    |
|LOGISTIC REGRESSION    |  P=0.015N*    P=0.104N     P=0.049N*    P=0.030N*  |  P=0.404      P=0.761      P=0.733N     P=0.554    |
|COCHRAN-ARMITAGE       |  P=0.010N**                                        |  P=0.351                                           |
|FISHER EXACT           |               P=0.102N     P=0.047N*    P=0.016N*  |               P=0.752N     P=0.752N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.8%         0.0%         2.9%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/27 (4%)    0/36 (0%)    1/34 (3%)    0/17 (0%)  |  0/36 (0%)    0/35 (0%)    0/41 (0%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   652          ---          728 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.250N     P=0.206N     P=0.449N     P=0.352N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.264N     P=0.260N     P=0.488N     P=0.373N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.237N     P=0.238N     P=0.486N     P=0.319N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.188N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248N     P=0.500N     P=0.248N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE   3
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)   3/60 (5%)    3/60 (5%)    1/60 (2%)  |  1/60 (2%)    1/60 (2%)    1/60 (2%)    2/60 (3%)  |
|ADJUSTED (b)           |  26.2%         7.6%         8.4%         2.3%      |   2.8%         2.7%         2.4%         4.8%      |
|TERMINAL (d)           |  4/27 (15%)   2/36 (6%)    2/34 (6%)    0/17 (0%)  |  1/36 (3%)    0/35 (0%)    1/41 (2%)    2/42 (5%)  |
|FIRST INCIDENCE (DAYS) |   461          702          727          486       |   729 (T)      727          729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.013N*    P=0.019N*    P=0.023N*    P=0.039N*  |  P=0.410      P=0.754      P=0.733N     P=0.554    |
|INCIDENTAL TUMOR       |  P=0.009N**   P=0.059N     P=0.052N     P=0.017N*  |  P=0.403      P=0.754N     P=0.733N     P=0.554    |
|LOGISTIC REGRESSION    |  P=0.007N**   P=0.040N*    P=0.038N*    P=0.012N*  |  P=0.404      P=0.761      P=0.733N     P=0.554    |
|COCHRAN-ARMITAGE       |  P=0.004N**                                        |  P=0.351                                           |
|FISHER EXACT           |               P=0.037N*    P=0.037N*    P=0.004N** |               P=0.752N     P=0.752N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.7%         0.0%         5.6%         0.0%      |   4.8%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/36 (0%)    1/34 (3%)    0/17 (0%)  |  1/36 (3%)    0/35 (0%)    0/41 (0%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   689          ---          727          ---       |   647          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.585N     P=0.457N     P=0.573      P=0.595N   |  P=0.103N     P=0.243N     P=0.221N     P=0.210N   |
|INCIDENTAL TUMOR       |  P=0.606N     P=0.602N     P=0.444      P=0.638N   |  P=0.106N     P=0.233N     P=0.225N     P=0.214N   |
|LOGISTIC REGRESSION    |  P=0.572N     P=0.500N     P=0.532      P=0.573N   |  P=0.112N     P=0.233N     P=0.231N     P=0.231N   |
|COCHRAN-ARMITAGE       |  P=0.461N                                          |  P=0.115N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500N   |               P=0.248N     P=0.248N     P=0.248N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE   4
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.7%         0.0%         5.6%         0.0%      |   4.8%         0.0%         2.4%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/36 (0%)    1/34 (3%)    0/17 (0%)  |  1/36 (3%)    0/35 (0%)    1/41 (2%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   689          ---          727          ---       |   647          ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.585N     P=0.457N     P=0.573      P=0.595N   |  P=0.165N     P=0.243N     P=0.465N     P=0.210N   |
|INCIDENTAL TUMOR       |  P=0.606N     P=0.602N     P=0.444      P=0.638N   |  P=0.168N     P=0.233N     P=0.470N     P=0.214N   |
|LOGISTIC REGRESSION    |  P=0.572N     P=0.500N     P=0.532      P=0.573N   |  P=0.179N     P=0.233N     P=0.482N     P=0.231N   |
|COCHRAN-ARMITAGE       |  P=0.461N                                          |  P=0.188N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500N   |               P=0.248N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/58 (3%)    0/59 (0%)    1/57 (2%)  |  0/59 (0%)    0/60 (0%)    0/59 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   3.7%         5.6%         0.0%         5.6%      |   0.0%         0.0%         0.0%         2.4%      |
|TERMINAL (d)           |  1/27 (4%)    2/36 (6%)    0/34 (0%)    0/17 (0%)  |  0/36 (0%)    0/35 (0%)    0/41 (0%)    1/42 (2%)  |
|FIRST INCIDENCE (DAYS) |   728 (T)      728 (T)      ---          727       |   ---          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.648N     P=0.600      P=0.454N     P=0.656    |  P=0.221        (e)          (e)        P=0.531    |
|INCIDENTAL TUMOR       |  P=0.644      P=0.600      P=0.454N     P=0.627    |  P=0.221        (e)          (e)        P=0.531    |
|LOGISTIC REGRESSION    |  P=0.636N     P=0.600      P=0.454N     P=0.672    |  P=0.221        (e)          (e)        P=0.531    |
|COCHRAN-ARMITAGE       |  P=0.513N                                          |  P=0.200                                           |
|FISHER EXACT           |               P=0.487      P=0.504N     P=0.739    |                 (e)          (e)        P=0.504    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE   5
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    2/60 (3%)    0/59 (0%)    0/59 (0%)  |  0/59 (0%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         5.6%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    2/36 (6%)    0/34 (0%)    0/17 (0%)  |  0/36 (0%)    0/35 (0%)    0/41 (0%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          728 (T)      ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.496N     P=0.303        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.496N     P=0.303        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.496N     P=0.303        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.406N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.252        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/59 (5%)    5/60 (8%)    2/59 (3%)    0/59 (0%)  |  2/59 (3%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   9.3%        12.9%         4.1%         0.0%      |   3.9%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/27 (7%)    4/36 (11%)   0/34 (0%)    0/17 (0%)  |  0/36 (0%)    0/35 (0%)    0/41 (0%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   636          621          486          ---       |   258          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.104N     P=0.476      P=0.446N     P=0.227N   |  P=0.111N     P=0.233N     P=0.233N     P=0.228N   |
|INCIDENTAL TUMOR       |  P=0.057N     P=0.411      P=0.524N     P=0.163N   |  P=0.145N     P=0.261N     P=0.377N     P=0.261N   |
|LOGISTIC REGRESSION    |  P=0.072N     P=0.383      P=0.499N     P=0.193N   |  P=0.125N     P=0.276N     P=0.308N     P=0.247N   |
|COCHRAN-ARMITAGE       |  P=0.051N                                          |  P=0.114N                                          |
|FISHER EXACT           |               P=0.368      P=0.500N     P=0.122N   |               P=0.244N     P=0.248N     P=0.244N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE   6
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/59 (3%)    2/60 (3%)    4/59 (7%)    3/59 (5%)  |  0/59 (0%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.9%         4.6%        11.3%        12.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    0/36 (0%)    3/34 (9%)    0/17 (0%)  |  0/36 (0%)    0/35 (0%)    0/41 (0%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   647          706          727          630       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.155      P=0.610N     P=0.426      P=0.298    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.167      P=0.521      P=0.320      P=0.291    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.129      P=0.329      P=0.371      P=0.146    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.355                                           |    (e)                                             |
|FISHER EXACT           |               P=0.684N     P=0.340      P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/59 (68%)  41/60 (68%)  44/59 (75%)  26/59 (44%) | 29/59 (49%)  30/60 (50%)  31/59 (53%)  29/60 (48%) |
|ADJUSTED (b)           |  90.3%        81.7%        86.1%        85.1%      |  66.8%        72.6%        62.6%        62.7%      |
|TERMINAL (d)           | 23/27 (85%)  27/36 (75%)  27/34 (79%)  13/17 (76%) | 22/36 (61%)  24/35 (69%)  23/41 (56%)  25/42 (60%) |
|FIRST INCIDENCE (DAYS) |   498          312          526          396       |   472          576          440          646       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.389      P=0.132N     P=0.368N     P=0.527    |  P=0.187N     P=0.461      P=0.463N     P=0.276N   |
|INCIDENTAL TUMOR       |  P=0.256N     P=0.575N     P=0.346      P=0.315N   |  P=0.270N     P=0.501      P=0.526N     P=0.335N   |
|LOGISTIC REGRESSION    |  P=0.276N     P=0.542      P=0.330      P=0.326N   |  P=0.335N     P=0.550N     P=0.556      P=0.366N   |
|COCHRAN-ARMITAGE       |  P=0.003N**                                        |  P=0.500N                                          |
|FISHER EXACT           |               P=0.553      P=0.271      P=0.008N** |               P=0.536      P=0.427      P=0.537N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE   7
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 25/59 (42%)  29/60 (48%)  35/59 (59%)  19/59 (32%) | 25/59 (42%)  26/60 (43%)  22/59 (37%)  12/60 (20%) |
|ADJUSTED (b)           |  59.4%        61.9%        70.3%        58.8%      |  53.9%        53.2%        46.4%        25.7%      |
|TERMINAL (d)           | 12/27 (44%)  19/36 (53%)  20/34 (59%)   5/17 (29%) | 15/36 (42%)  13/35 (37%)  16/41 (39%)   8/42 (19%) |
|FIRST INCIDENCE (DAYS) |   461          469          434          511       |   583          570          646          651       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.190      P=0.464N     P=0.253      P=0.332    |  P=0.001N**   P=0.491      P=0.212N     P=0.004N** |
|INCIDENTAL TUMOR       |  P=0.469N     P=0.255      P=0.052      P=0.540N   |  P<0.001N**   P=0.536N     P=0.254N     P=0.003N** |
|LOGISTIC REGRESSION    |  P=0.498      P=0.306      P=0.050      P=0.565    |  P<0.001N**   P=0.474N     P=0.243N     P=0.003N** |
|COCHRAN-ARMITAGE       |  P=0.132N                                          |  P=0.003N**                                        |
|FISHER EXACT           |               P=0.320      P=0.049 *    P=0.171N   |               P=0.532      P=0.354N     P=0.007N** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/59 (46%)  31/60 (52%)  36/59 (61%)  20/59 (34%) | 25/59 (42%)  26/60 (43%)  22/59 (37%)  12/60 (20%) |
|ADJUSTED (b)           |  61.4%        63.7%        71.1%        60.3%      |  53.9%        53.2%        46.4%        25.7%      |
|TERMINAL (d)           | 12/27 (44%)  19/36 (53%)  20/34 (59%)   5/17 (29%) | 15/36 (42%)  13/35 (37%)  16/41 (39%)   8/42 (19%) |
|FIRST INCIDENCE (DAYS) |   461          469          434          511       |   583          570          646          651       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.223      P=0.439N     P=0.321      P=0.351    |  P=0.001N**   P=0.491      P=0.212N     P=0.004N** |
|INCIDENTAL TUMOR       |  P=0.422N     P=0.206      P=0.062      P=0.500N   |  P<0.001N**   P=0.536N     P=0.254N     P=0.003N** |
|LOGISTIC REGRESSION    |  P=0.524N     P=0.307      P=0.072      P=0.569    |  P<0.001N**   P=0.474N     P=0.243N     P=0.003N** |
|COCHRAN-ARMITAGE       |  P=0.091N                                          |  P=0.003N**                                        |
|FISHER EXACT           |               P=0.323      P=0.070      P=0.130N   |               P=0.532      P=0.354N     P=0.007N** |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE   8
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 47/59 (80%)  52/60 (87%)  54/59 (92%)  36/59 (61%) | 41/59 (69%)  44/60 (73%)  40/59 (68%)  36/60 (60%) |
|ADJUSTED (b)           |  95.8%        92.9%        96.4%        94.4%      |  83.6%        86.1%        78.1%        73.2%      |
|TERMINAL (d)           | 25/27 (93%)  32/36 (89%)  32/34 (94%)  15/17 (88%) | 28/36 (78%)  28/35 (80%)  30/41 (73%)  29/42 (69%) |
|FIRST INCIDENCE (DAYS) |   461          312          434          396       |   472          570          440          646       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.097      P=0.238N     P=0.476N     P=0.171    |  P=0.016N*    P=0.350      P=0.219N     P=0.054N   |
|INCIDENTAL TUMOR       |  P=0.510N     P=0.125      P=0.065      P=0.479    |  P=0.021N*    P=0.441      P=0.246N     P=0.049N*  |
|LOGISTIC REGRESSION    |  P=0.504      P=0.117      P=0.052      P=0.402    |  P=0.026N*    P=0.504      P=0.299N     P=0.061N   |
|COCHRAN-ARMITAGE       |  P=0.003N**                                        |  P=0.099N                                          |
|FISHER EXACT           |               P=0.219      P=0.057      P=0.022N*  |               P=0.397      P=0.500N     P=0.186N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 48/59 (81%)  52/60 (87%)  54/59 (92%)  36/59 (61%) | 41/59 (69%)  44/60 (73%)  40/59 (68%)  36/60 (60%) |
|ADJUSTED (b)           |  95.9%        92.9%        96.4%        94.4%      |  83.6%        86.1%        78.1%        73.2%      |
|TERMINAL (d)           | 25/27 (93%)  32/36 (89%)  32/34 (94%)  15/17 (88%) | 28/36 (78%)  28/35 (80%)  30/41 (73%)  29/42 (69%) |
|FIRST INCIDENCE (DAYS) |   461          312          434          396       |   472          570          440          646       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.120      P=0.192N     P=0.414N     P=0.206    |  P=0.016N*    P=0.350      P=0.219N     P=0.054N   |
|INCIDENTAL TUMOR       |  P=0.431N     P=0.166      P=0.094      P=0.551    |  P=0.021N*    P=0.441      P=0.246N     P=0.049N*  |
|LOGISTIC REGRESSION    |  P=0.521N     P=0.169      P=0.084      P=0.484    |  P=0.026N*    P=0.504      P=0.299N     P=0.061N   |
|COCHRAN-ARMITAGE       |  P=0.002N**                                        |  P=0.099N                                          |
|FISHER EXACT           |               P=0.295      P=0.089      P=0.012N*  |               P=0.397      P=0.500N     P=0.186N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE   9
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/60 (20%)   6/60 (10%)   6/60 (10%)   4/60 (7%)  |  2/59 (3%)    3/60 (5%)    5/60 (8%)    1/60 (2%)  |
|ADJUSTED (b)           |  33.6%        16.7%        15.4%        15.3%      |   4.7%         8.1%        10.7%         2.4%      |
|TERMINAL (d)           |  5/27 (19%)   6/36 (17%)   3/34 (9%)    2/17 (12%) |  1/36 (3%)    2/35 (6%)    2/41 (5%)    1/42 (2%)  |
|FIRST INCIDENCE (DAYS) |   636          728 (T)      646          174       |   584          715          647          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.124N     P=0.035N*    P=0.051N     P=0.163N   |  P=0.328N     P=0.496      P=0.267      P=0.451N   |
|INCIDENTAL TUMOR       |  P=0.065N     P=0.103N     P=0.128N     P=0.062N   |  P=0.385N     P=0.536      P=0.201      P=0.583N   |
|LOGISTIC REGRESSION    |  P=0.067N     P=0.059N     P=0.075N     P=0.066N   |  P=0.371N     P=0.517      P=0.233      P=0.491N   |
|COCHRAN-ARMITAGE       |  P=0.028N*                                         |  P=0.391N                                          |
|FISHER EXACT           |               P=0.100N     P=0.100N     P=0.029N*  |               P=0.508      P=0.226      P=0.494N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    2/60 (3%)    3/60 (5%)    3/60 (5%)  |  3/59 (5%)    2/60 (3%)    1/60 (2%)    2/60 (3%)  |
|ADJUSTED (b)           |  11.4%         4.8%         7.6%         8.7%      |   8.0%         4.7%         1.8%         4.3%      |
|TERMINAL (d)           |  2/27 (7%)    1/36 (3%)    1/34 (3%)    0/17 (0%)  |  2/36 (6%)    1/35 (3%)    0/41 (0%)    1/42 (2%)  |
|FIRST INCIDENCE (DAYS) |   498          647          675          318       |   727          576          591          675       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.455      P=0.267N     P=0.409N     P=0.609    |  P=0.342N     P=0.505N     P=0.263N     P=0.432N   |
|INCIDENTAL TUMOR       |  P=0.489N     P=0.370N     P=0.551N     P=0.399N   |  P=0.473N     P=0.464N     P=0.342N     P=0.442N   |
|LOGISTIC REGRESSION    |  P=0.499N     P=0.336N     P=0.500N     P=0.476N   |  P=0.394N     P=0.483N     P=0.290N     P=0.453N   |
|COCHRAN-ARMITAGE       |  P=0.500N                                          |  P=0.398N                                          |
|FISHER EXACT           |               P=0.340N     P=0.500N     P=0.500N   |               P=0.492N     P=0.303N     P=0.492N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  10
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 15/60 (25%)   8/60 (13%)   9/60 (15%)   7/60 (12%) |  4/59 (7%)    5/60 (8%)    6/60 (10%)   3/60 (5%)  |
|ADJUSTED (b)           |  39.3%        21.2%        22.1%        22.6%      |   9.9%        12.6%        12.4%         6.7%      |
|TERMINAL (d)           |  6/27 (22%)   7/36 (19%)   4/34 (12%)   2/17 (12%) |  2/36 (6%)    3/35 (9%)    2/41 (5%)    2/42 (5%)  |
|FIRST INCIDENCE (DAYS) |   498          647          646          174       |   584          576          591          675       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.279N     P=0.028N*    P=0.063N     P=0.276N   |  P=0.313N     P=0.495      P=0.444      P=0.422N   |
|INCIDENTAL TUMOR       |  P=0.107N     P=0.098N     P=0.181N     P=0.058N   |  P=0.446N     P=0.557      P=0.318      P=0.517N   |
|LOGISTIC REGRESSION    |  P=0.108N     P=0.071N     P=0.110N     P=0.074N   |  P=0.379N     P=0.523      P=0.392      P=0.470N   |
|COCHRAN-ARMITAGE       |  P=0.058N                                          |  P=0.393N                                          |
|FISHER EXACT           |               P=0.082N     P=0.127N     P=0.049N*  |               P=0.511      P=0.382      P=0.491N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/58 (3%)    0/58 (0%)    3/60 (5%)    3/59 (5%)  |
|ADJUSTED (b)           |                                                    |   4.6%         0.0%         6.9%         6.4%      |
|TERMINAL (d)           |                                                    |  1/35 (3%)    0/34 (0%)    2/41 (5%)    1/41 (2%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   331          ---          702          646       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.288      P=0.239N     P=0.556      P=0.555    |
|INCIDENTAL TUMOR       |                                                    |  P=0.263      P=0.275N     P=0.482      P=0.518    |
|LOGISTIC REGRESSION    |                                                    |  P=0.236      P=0.265N     P=0.502      P=0.494    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.240                                           |
|FISHER EXACT           |                                                    |               P=0.248N     P=0.516      P=0.508    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  11
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/52 (0%)    1/57 (2%)    0/56 (0%)    0/53 (0%)  | 11/56 (20%)  18/57 (32%)  15/60 (25%)  18/60 (30%) |
|ADJUSTED (b)           |   0.0%         2.9%         0.0%         0.0%      |  30.1%        44.8%        33.6%        39.7%      |
|TERMINAL (d)           |  0/26 (0%)    1/35 (3%)    0/32 (0%)    0/17 (0%)  | 10/35 (29%)  13/34 (38%)  12/41 (29%)  15/42 (36%) |
|FIRST INCIDENCE (DAYS) |   ---          728 (T)      ---          ---       |   601          577          591          675       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.646N     P=0.559        (e)          (e)      |  P=0.358      P=0.089      P=0.408      P=0.225    |
|INCIDENTAL TUMOR       |  P=0.646N     P=0.559        (e)          (e)      |  P=0.262      P=0.142      P=0.370      P=0.202    |
|LOGISTIC REGRESSION    |  P=0.646N     P=0.559        (e)          (e)      |  P=0.296      P=0.119      P=0.382      P=0.206    |
|COCHRAN-ARMITAGE       |  P=0.569N                                          |  P=0.210                                           |
|FISHER EXACT           |               P=0.523        (e)          (e)      |               P=0.108      P=0.320      P=0.142    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    2/60 (3%)  |
|ADJUSTED (b)           |   1.9%         1.9%         0.0%         0.0%      |   0.0%         2.9%         0.0%         4.2%      |
|TERMINAL (d)           |  0/27 (0%)    0/36 (0%)    0/34 (0%)    0/17 (0%)  |  0/36 (0%)    1/35 (3%)    0/41 (0%)    1/42 (2%)  |
|FIRST INCIDENCE (DAYS) |   589          615          ---          ---       |   ---          729 (T)      ---          646       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.304N     P=0.756      P=0.504N     P=0.598N   |  P=0.170      P=0.494        (e)        P=0.272    |
|INCIDENTAL TUMOR       |  P=0.189N     P=0.659      P=0.500N     P=0.455N   |  P=0.165      P=0.494        (e)        P=0.267    |
|LOGISTIC REGRESSION    |  P=0.193N     P=0.741N     P=0.475N     P=0.483N   |  P=0.146      P=0.494        (e)        P=0.243    |
|COCHRAN-ARMITAGE       |  P=0.236N                                          |  P=0.140                                           |
|FISHER EXACT           |               P=0.752N     P=0.500N     P=0.500N   |               P=0.500        (e)        P=0.248    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  12
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         5.6%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/27 (0%)    2/36 (6%)    0/34 (0%)    0/17 (0%)  |  0/36 (0%)    0/35 (0%)    0/41 (0%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          728 (T)      ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.496N     P=0.303        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.496N     P=0.303        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.496N     P=0.303        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.405N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/59 (2%)    2/59 (3%)    1/59 (2%)    1/57 (2%)  |  1/59 (2%)    1/60 (2%)    0/59 (0%)    1/59 (2%)  |
|ADJUSTED (b)           |   2.0%         4.7%         2.9%         5.9%      |   2.8%         2.9%         0.0%         2.2%      |
|TERMINAL (d)           |  0/27 (0%)    1/36 (3%)    1/34 (3%)    1/17 (6%)  |  1/36 (3%)    1/35 (3%)    0/41 (0%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   636          621          728 (T)      728 (T)   |   729 (T)      729 (T)      ---          707       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.563      P=0.528      P=0.740N     P=0.636    |  P=0.576N     P=0.756      P=0.474N     P=0.733N   |
|INCIDENTAL TUMOR       |  P=0.569N     P=0.423      P=0.751N     P=0.737    |  P=0.587N     P=0.756      P=0.474N     P=0.743N   |
|LOGISTIC REGRESSION    |  P=0.626      P=0.503      P=0.762N     P=0.687    |  P=0.589N     P=0.756      P=0.474N     P=0.743N   |
|COCHRAN-ARMITAGE       |  P=0.542N                                          |  P=0.617N                                          |
|FISHER EXACT           |               P=0.500      P=0.752N     P=0.743    |               P=0.748N     P=0.500N     P=0.752N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  13
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    1/60 (2%)    2/60 (3%)    2/60 (3%)  |
|ADJUSTED (b)           |   2.9%         5.0%         0.0%         0.0%      |   0.0%         2.2%         4.9%         4.6%      |
|TERMINAL (d)           |  0/27 (0%)    1/36 (3%)    0/34 (0%)    0/17 (0%)  |  0/36 (0%)    0/35 (0%)    2/41 (5%)    1/42 (2%)  |
|FIRST INCIDENCE (DAYS) |   707          707          ---          ---       |   ---          684          729 (T)      727       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.239N     P=0.587      P=0.463N     P=0.578N   |  P=0.201      P=0.513      P=0.267      P=0.273    |
|INCIDENTAL TUMOR       |  P=0.282N     P=0.415      P=0.571N     P=0.638N   |  P=0.192      P=0.517      P=0.267      P=0.267    |
|LOGISTIC REGRESSION    |  P=0.244N     P=0.537      P=0.489N     P=0.585N   |  P=0.185      P=0.504      P=0.267      P=0.267    |
|COCHRAN-ARMITAGE       |  P=0.188N                                          |  P=0.160                                           |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.500N   |               P=0.500      P=0.248      P=0.248    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    1/60 (2%)    2/60 (3%)    2/60 (3%)  |
|ADJUSTED (b)           |   0.0%         5.0%         0.0%         0.0%      |   0.0%         2.2%         4.9%         4.6%      |
|TERMINAL (d)           |  0/27 (0%)    1/36 (3%)    0/34 (0%)    0/17 (0%)  |  0/36 (0%)    0/35 (0%)    2/41 (5%)    1/42 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          707          ---          ---       |   ---          684          729 (T)      727       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.490N     P=0.299        (e)          (e)      |  P=0.201      P=0.513      P=0.267      P=0.273    |
|INCIDENTAL TUMOR       |  P=0.513N     P=0.212        (e)          (e)      |  P=0.192      P=0.517      P=0.267      P=0.267    |
|LOGISTIC REGRESSION    |  P=0.489N     P=0.267        (e)          (e)      |  P=0.185      P=0.504      P=0.267      P=0.267    |
|COCHRAN-ARMITAGE       |  P=0.405N                                          |  P=0.160                                           |
|FISHER EXACT           |               P=0.248        (e)          (e)      |               P=0.500      P=0.248      P=0.248    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  14
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/59 (0%)    4/59 (7%)    1/57 (2%)  |  2/58 (3%)    3/60 (5%)    2/59 (3%)    9/59 (15%) |
|ADJUSTED (b)           |   3.6%         0.0%        10.1%         5.9%      |   5.6%         8.6%         4.9%        19.6%      |
|TERMINAL (d)           |  0/27 (0%)    0/36 (0%)    2/34 (6%)    1/17 (6%)  |  2/36 (6%)    3/35 (9%)    2/41 (5%)    6/42 (14%) |
|FIRST INCIDENCE (DAYS) |   727          ---          616          728 (T)   |   729 (T)      729 (T)      729 (T)      646       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.269      P=0.434N     P=0.247      P=0.656    |  P=0.016 *    P=0.487      P=0.647N     P=0.052    |
|INCIDENTAL TUMOR       |  P=0.314      P=0.619N     P=0.159      P=0.627    |  P=0.013 *    P=0.487      P=0.647N     P=0.044 *  |
|LOGISTIC REGRESSION    |  P=0.301      P=0.439N     P=0.186      P=0.672    |  P=0.011 *    P=0.487      P=0.647N     P=0.040 *  |
|COCHRAN-ARMITAGE       |  P=0.426                                           |  P=0.007 **                                        |
|FISHER EXACT           |               P=0.504N     P=0.177      P=0.739    |               P=0.516      P=0.684N     P=0.028 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/59 (0%)    4/59 (7%)    2/57 (4%)  |  2/58 (3%)    3/60 (5%)    2/59 (3%)    9/59 (15%) |
|ADJUSTED (b)           |   3.6%         0.0%        10.1%         8.7%      |   5.6%         8.6%         4.9%        19.6%      |
|TERMINAL (d)           |  0/27 (0%)    0/36 (0%)    2/34 (6%)    1/17 (6%)  |  2/36 (6%)    3/35 (9%)    2/41 (5%)    6/42 (14%) |
|FIRST INCIDENCE (DAYS) |   727          ---          616          580       |   729 (T)      729 (T)      729 (T)      646       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.099      P=0.434N     P=0.247      P=0.345    |  P=0.016 *    P=0.487      P=0.647N     P=0.052    |
|INCIDENTAL TUMOR       |  P=0.162      P=0.619N     P=0.159      P=0.395    |  P=0.013 *    P=0.487      P=0.647N     P=0.044 *  |
|LOGISTIC REGRESSION    |  P=0.144      P=0.439N     P=0.186      P=0.386    |  P=0.011 *    P=0.487      P=0.647N     P=0.040 *  |
|COCHRAN-ARMITAGE       |  P=0.222                                           |  P=0.007 **                                        |
|FISHER EXACT           |               P=0.504N     P=0.177      P=0.481    |               P=0.516      P=0.684N     P=0.028 *  |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  15
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/60 (2%)    0/60 (0%)    1/60 (2%)    2/60 (3%)  |
|ADJUSTED (b)           |                                                    |   2.5%         0.0%         2.4%         4.4%      |
|TERMINAL (d)           |                                                    |  0/36 (0%)    0/35 (0%)    1/41 (2%)    1/42 (2%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   714          ---          729 (T)      687       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.290      P=0.505N     P=0.738N     P=0.546    |
|INCIDENTAL TUMOR       |                                                    |  P=0.279      P=0.483N     P=0.746N     P=0.538    |
|LOGISTIC REGRESSION    |                                                    |  P=0.270      P=0.492N     P=0.742N     P=0.527    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.248                                           |
|FISHER EXACT           |                                                    |               P=0.500N     P=0.752N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/60 (2%)    1/60 (2%)    1/60 (2%)    2/60 (3%)  |
|ADJUSTED (b)           |                                                    |   2.5%         2.9%         2.4%         4.4%      |
|TERMINAL (d)           |                                                    |  0/36 (0%)    1/35 (3%)    1/41 (2%)    1/42 (2%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   714          729 (T)      729 (T)      687       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.405      P=0.754      P=0.738N     P=0.546    |
|INCIDENTAL TUMOR       |                                                    |  P=0.395      P=0.754N     P=0.746N     P=0.538    |
|LOGISTIC REGRESSION    |                                                    |  P=0.384      P=0.755N     P=0.742N     P=0.527    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.351                                           |
|FISHER EXACT           |                                                    |               P=0.752N     P=0.752N     P=0.500    |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  16
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    6/60 (10%)   1/60 (2%)    1/60 (2%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    3/60 (5%)  |
|ADJUSTED (b)           |   0.0%        15.1%         2.9%         4.3%      |   0.0%         2.9%         0.0%         6.6%      |
|TERMINAL (d)           |  0/27 (0%)    4/36 (11%)   1/34 (3%)    0/17 (0%)  |  0/36 (0%)    1/35 (3%)    0/41 (0%)    2/42 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          705          728 (T)      707       |   ---          729 (T)      ---          668       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.593N     P=0.040 *    P=0.546      P=0.422    |  P=0.060      P=0.494        (e)        P=0.153    |
|INCIDENTAL TUMOR       |  P=0.589      P=0.018 *    P=0.546      P=0.362    |  P=0.058      P=0.494        (e)        P=0.147    |
|LOGISTIC REGRESSION    |  P=0.589N     P=0.028 *    P=0.546      P=0.415    |  P=0.050      P=0.494        (e)        P=0.133    |
|COCHRAN-ARMITAGE       |  P=0.404N                                          |  P=0.044 *                                         |
|FISHER EXACT           |               P=0.014 *    P=0.500      P=0.500    |               P=0.500        (e)        P=0.122    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    7/60 (12%)   3/60 (5%)    2/60 (3%)  |  5/60 (8%)    2/60 (3%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |  12.9%        17.7%         6.9%        11.8%      |  11.9%         5.7%         2.2%         2.2%      |
|TERMINAL (d)           |  3/27 (11%)   5/36 (14%)   1/34 (3%)    2/17 (12%) |  3/36 (8%)    2/35 (6%)    0/41 (0%)    0/42 (0%)  |
|FIRST INCIDENCE (DAYS) |   636          621          486          728 (T)   |   258          729 (T)      707          707       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.331N     P=0.410      P=0.419N     P=0.576N   |  P=0.047N*    P=0.225N     P=0.089N     P=0.085N   |
|INCIDENTAL TUMOR       |  P=0.233N     P=0.307      P=0.478N     P=0.504N   |  P=0.055N     P=0.252N     P=0.122N     P=0.100N   |
|LOGISTIC REGRESSION    |  P=0.279N     P=0.300      P=0.500N     P=0.549N   |  P=0.062N     P=0.224N     P=0.113N     P=0.112N   |
|COCHRAN-ARMITAGE       |  P=0.147N                                          |  P=0.060N                                          |
|FISHER EXACT           |               P=0.264      P=0.500N     P=0.340N   |               P=0.219N     P=0.103N     P=0.103N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  17
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)   13/60 (22%)   4/60 (7%)    3/60 (5%)  |  5/60 (8%)    3/60 (5%)    1/60 (2%)    4/60 (7%)  |
|ADJUSTED (b)           |  12.9%        31.6%         9.8%        15.6%      |  11.9%         8.6%         2.2%         8.7%      |
|TERMINAL (d)           |  3/27 (11%)   9/36 (25%)   2/34 (6%)    2/17 (12%) |  3/36 (8%)    3/35 (9%)    0/41 (0%)    2/42 (5%)  |
|FIRST INCIDENCE (DAYS) |   636          621          486          707       |   258          729 (T)      707          668       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.349N     P=0.062      P=0.551N     P=0.559    |  P=0.366N     P=0.365N     P=0.089N     P=0.424N   |
|INCIDENTAL TUMOR       |  P=0.279N     P=0.023 *    P=0.607N     P=0.602    |  P=0.395N     P=0.398N     P=0.122N     P=0.464N   |
|LOGISTIC REGRESSION    |  P=0.308N     P=0.027 *    P=0.641N     P=0.582    |  P=0.439N     P=0.360N     P=0.113N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.122N                                          |  P=0.443N                                          |
|FISHER EXACT           |               P=0.017 *    P=0.641N     P=0.500N   |               P=0.359N     P=0.103N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |  3/60 (5%)    1/60 (2%)    0/60 (0%)    3/60 (5%)  |
|ADJUSTED (b)           |   7.0%         2.8%         4.7%         0.0%      |   7.2%         2.2%         0.0%         6.6%      |
|TERMINAL (d)           |  1/27 (4%)    1/36 (3%)    1/34 (3%)    0/17 (0%)  |  1/36 (3%)    0/35 (0%)    0/41 (0%)    2/42 (5%)  |
|FIRST INCIDENCE (DAYS) |   709          728 (T)      580          ---       |   583          696          ---          651       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.288N     P=0.391N     P=0.622N     P=0.329N   |  P=0.583      P=0.308N     P=0.105N     P=0.594N   |
|INCIDENTAL TUMOR       |  P=0.264N     P=0.492N     P=0.684N     P=0.373N   |  P=0.505      P=0.259N     P=0.154N     P=0.636    |
|LOGISTIC REGRESSION    |  P=0.265N     P=0.428N     P=0.693N     P=0.336N   |  P=0.537      P=0.299N     P=0.118N     P=0.648N   |
|COCHRAN-ARMITAGE       |  P=0.200N                                          |  P=0.526                                           |
|FISHER EXACT           |               P=0.500N     P=0.691N     P=0.248N   |               P=0.309N     P=0.122N     P=0.660N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  18
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/60 (15%)   3/60 (5%)    6/60 (10%)   2/60 (3%)  | 20/60 (33%)  23/60 (38%)  21/60 (35%)  17/60 (28%) |
|ADJUSTED (b)           |  23.7%         7.6%        14.1%         6.9%      |  44.1%        54.0%        46.2%        35.5%      |
|TERMINAL (d)           |  3/27 (11%)   2/36 (6%)    2/34 (6%)    0/17 (0%)  | 12/36 (33%)  16/35 (46%)  17/41 (41%)  12/42 (29%) |
|FIRST INCIDENCE (DAYS) |   486          702          580          625       |   469          504          646          595       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.138N     P=0.033N*    P=0.211N     P=0.133N   |  P=0.096N     P=0.345      P=0.472N     P=0.201N   |
|INCIDENTAL TUMOR       |  P=0.085N     P=0.104N     P=0.352N     P=0.078N   |  P=0.148N     P=0.317      P=0.530N     P=0.342N   |
|LOGISTIC REGRESSION    |  P=0.075N     P=0.065N     P=0.291N     P=0.068N   |  P=0.163N     P=0.403      P=0.575N     P=0.292N   |
|COCHRAN-ARMITAGE       |  P=0.041N*                                         |  P=0.237N                                          |
|FISHER EXACT           |               P=0.063N     P=0.291N     P=0.027N*  |               P=0.352      P=0.500      P=0.346N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)   2/60 (3%)    5/60 (8%)    2/60 (3%)  | 17/60 (28%)  22/60 (37%)  21/60 (35%)  14/60 (23%) |
|ADJUSTED (b)           |  17.7%         4.9%        12.5%         6.9%      |  38.9%        53.0%        46.2%        29.9%      |
|TERMINAL (d)           |  2/27 (7%)    1/36 (3%)    2/34 (6%)    0/17 (0%)  | 11/36 (31%)  16/35 (46%)  17/41 (41%)  10/42 (24%) |
|FIRST INCIDENCE (DAYS) |   486          702          622          625       |   469          504          646          595       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.270N     P=0.054N     P=0.300N     P=0.251N   |  P=0.084N     P=0.214      P=0.442      P=0.205N   |
|INCIDENTAL TUMOR       |  P=0.186N     P=0.142N     P=0.448N     P=0.151N   |  P=0.123N     P=0.169      P=0.412      P=0.320N   |
|LOGISTIC REGRESSION    |  P=0.171N     P=0.083N     P=0.380N     P=0.138N   |  P=0.141N     P=0.256      P=0.347      P=0.289N   |
|COCHRAN-ARMITAGE       |  P=0.110N                                          |  P=0.211N                                          |
|FISHER EXACT           |               P=0.081N     P=0.381N     P=0.081N   |               P=0.218      P=0.278      P=0.339N   |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  19
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 47/60 (78%)  49/60 (82%)  50/60 (83%)  31/60 (52%) | 38/60 (63%)  40/60 (67%)  44/60 (73%)  45/60 (75%) |
|ADJUSTED (b)           |  93.7%        94.2%        94.3%        90.1%      |  84.1%        84.8%        82.8%        88.2%      |
|TERMINAL (d)           | 24/27 (89%)  33/36 (92%)  31/34 (91%)  14/17 (82%) | 29/36 (81%)  28/35 (80%)  32/41 (78%)  36/42 (86%) |
|FIRST INCIDENCE (DAYS) |   461          312          526          174       |   331          576           79          646       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.380      P=0.122N     P=0.271N     P=0.494    |  P=0.523      P=0.393      P=0.487      P=0.507    |
|INCIDENTAL TUMOR       |  P=0.138N     P=0.371      P=0.358      P=0.152N   |  P=0.233      P=0.461      P=0.301      P=0.328    |
|LOGISTIC REGRESSION    |  P=0.164N     P=0.319      P=0.353      P=0.188N   |  P=0.205      P=0.558      P=0.242      P=0.267    |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.081                                           |
|FISHER EXACT           |               P=0.410      P=0.322      P=0.002N** |               P=0.424      P=0.163      P=0.118    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 41/60 (68%)  40/60 (67%)  43/60 (72%)  27/60 (45%) | 41/60 (68%)  45/60 (75%)  40/60 (67%)  31/60 (52%) |
|ADJUSTED (b)           |  80.9%        75.0%        76.4%        70.3%      |  78.5%        81.8%        76.9%        57.2%      |
|TERMINAL (d)           | 18/27 (67%)  23/36 (64%)  21/34 (62%)   6/17 (35%) | 25/36 (69%)  25/35 (71%)  29/41 (71%)  19/42 (45%) |
|FIRST INCIDENCE (DAYS) |   461          210          434          318       |   258          504          591          595       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.390      P=0.135N     P=0.343N     P=0.504    |  P=0.004N**   P=0.326      P=0.238N     P=0.021N*  |
|INCIDENTAL TUMOR       |  P=0.072N     P=0.456      P=0.330      P=0.150N   |  P=0.004N**   P=0.343      P=0.354N     P=0.034N*  |
|LOGISTIC REGRESSION    |  P=0.103N     P=0.533N     P=0.423      P=0.219N   |  P=0.004N**   P=0.353      P=0.357N     P=0.026N*  |
|COCHRAN-ARMITAGE       |  P=0.004N**                                        |  P=0.012N*                                         |
|FISHER EXACT           |               P=0.500N     P=0.421      P=0.008N** |               P=0.272      P=0.500N     P=0.047N*  |
|=================================================================================================================================|
         DATE: 05/20/95                     EXPERIMENT: 05142 TEST: 04                                                 PAGE  20
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- T-BUTYL ALCOHOL
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.5%         1.0%         2.0%      |   VEHICLE      0.5%         1.0%         2.0%      |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 56/60 (93%)  56/60 (93%)  56/60 (93%)  43/60 (72%) | 54/60 (90%)  54/60 (90%)  55/60 (92%)  53/60 (88%) |
|ADJUSTED (b)           | 100.0%        98.2%        98.2%        97.7%      |  96.4%        96.4%        98.2%        94.6%      |
|TERMINAL (d)           | 27/27 (100%) 35/36 (97%)  33/34 (97%)  16/17 (94%) | 34/36 (94%)  33/35 (94%)  40/41 (98%)  39/42 (93%) |
|FIRST INCIDENCE (DAYS) |   461          210          434          174       |   258          504           79          595       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.084      P=0.061N     P=0.134N     P=0.156    |  P=0.060N     P=0.538      P=0.247N     P=0.111N   |
|INCIDENTAL TUMOR       |  P=0.196N     P=0.466      P=0.666N     P=0.470N   |  P=0.156N     P=0.477N     P=0.544N     P=0.245N   |
|LOGISTIC REGRESSION    |  P=0.280N     P=0.315      P=0.661      P=0.615N   |  P=0.281N     P=0.387N     P=0.629N     P=0.282N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.442N                                          |
|FISHER EXACT           |               P=0.641N     P=0.641N     P=0.002N** |               P=0.619N     P=0.500      P=0.500N   |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.