TDMS Study 05142-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 04 TIME: 08:43:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR. FARNELL CAS: 75-65-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYL ALCOHOL DATE: 05/20/95
EXPERIMENT: 05142 TEST: 04 TIME: 08:43:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55121 ROUTE: DOSED WATER NTP C#: 55367B
PATHOLOGIST: DR. FARNELL CAS: 75-65-0
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 362 461 486 496 498 560 589 616 631 633 |
| 636 638 643 647 647 652 652 653 653 673 |
| 673 675 675 689 692 702 707 707 707 707 |
| 708 709 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 2 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 210 312 469 531 531 597 615 621 630 640 |
| 645 647 702 705 706 707 709 710 724 727 |
| 727 727 |
| CENSORED DEATHS |
| 49 73 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 1 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 434 486 526 562 580 580 589 611 612 616 |
| 622 646 646 647 647 674 675 695 707 707 |
| 709 721 727 727 727 |
| CENSORED DEATHS |
| 76 |
| |
==================================================================================
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2.0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 43 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 93 94 106 112 118 125 139 146 174 189 |
| 269 318 360 370 386 396 460 486 486 489 |
| 511 529 531 552 567 577 580 602 611 614 |
| 625 628 630 671 684 684 687 707 708 709 |
| 709 726 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.3 98.3 96.7 91.7 88.3 68.3 45.0 |
|CONTROL | |
| | |
|0.5% | 100.0 100.0 98.3 96.6 96.6 94.8 91.4 89.7 79.3 62.1 |
| | |
| | |
|1.0% | 100.0 100.0 100.0 100.0 100.0 98.3 94.9 88.1 74.6 57.6 |
| | |
| | |
|2.0% | 100.0 85.0 81.7 78.3 73.3 71.7 61.7 53.3 45.0 28.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.5% 1.0% 2.0% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 45.0% 62.1% 57.6% 28.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.077N P=0.228N P=0.007 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 633.5 617.8 634.9 462.4 |
|NATURAL DEATHS (C) | (14.8) (29.2) (15.6) (33.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 676.0 665.4 678.4 537.7 |
|(STANDARD ERROR) | (10.1) (19.3) (13.4) (28.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 16 258 330 331 469 472 555 568 583 584 |
| 590 601 647 653 659 659 702 707 709 714 |
| 723 727 727 |
| CENSORED DEATHS |
| 170 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 3 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 504 550 570 576 577 610 616 628 633 635 |
| 674 684 696 696 704 707 709 710 715 724 |
| 727 727 |
| CENSORED DEATHS |
| 72 310 365 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 2 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 79 140 488 591 607 625 645 646 646 647 |
| 702 702 707 707 710 727 728 |
| CENSORED DEATHS |
| 440 506 |
| |
==================================================================================
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2.0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 2 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 224 472 595 632 646 651 651 668 675 687 |
| 695 702 707 726 727 727 |
| CENSORED DEATHS |
| 64 74 |
| |
==================================================================================
T-BUTYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.3 98.3 96.6 93.2 93.2 89.9 89.9 79.7 72.9 61.0 |
|CONTROL | |
| | |
|0.5% | 100.0 100.0 100.0 100.0 100.0 100.0 98.2 91.2 82.5 61.4 |
| | |
| | |
|1.0% | 98.3 96.7 96.7 96.7 96.7 96.7 95.0 93.2 82.9 70.8 |
| | |
| | |
|2.0% | 100.0 100.0 98.3 98.3 98.3 96.6 96.6 94.8 87.9 72.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.5% 1.0% 2.0% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 61.0% 61.4% 70.8% 72.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.121N P=0.924N P=0.298N P=0.198N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 564.5 653.3 593.9 636.6 |
|NATURAL DEATHS (C) | (37.7) (14.2) (46.7) (31.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 656.6 677.2 682.2 682.4 |
|(STANDARD ERROR) | (19.4) (15.0) (16.0) (17.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYL ALCOHOL
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
0.5% = 2
1.0% = 3
2.0% = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1 3
| 4 4 2 2 1 3 12 1 3
| 2 11 2 3
| 444 11 2 13 3 2
90 + 4 4 1 3 12 2
| 44 4 1 12 1
| 4 4 22 2
| 4 4 4 33 112
P 80 + 4 4 2 2
E | 44 4 11
R | 44 11 3
C | 4 4 4 22
E 70 + 3 332 2
N | 4 4 1 1
T | 4 4 333
| 4 4 1 1 32
S 60 + 4 4
U | 4 4 1 1 3
R | 4 4
V | 4 4
I 50 + 4 4 11
V | 1 1
A | 4 4 1
L | 4 4
40 + 44
| 4 44
|
| 4 4
30 +
| 4
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 28 obs hidden.
T-BUTYL ALCOHOL
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
0.5% = 2
1.0% = 3
2.0% = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 4 2
| 1 3 3 4 1 4 2 2
|
| 3 1 1 4 3 2 2 4
95 + 3 22 3 4
| 1 1 3 3
| 4 4
| 11 2 32 3
P 90 + 1 1 3 3
E | 1 1
R | 2 2 4 4
C | 1 1 22 44
E 85 + 4 4
N |
T | 1 1 2 3 2 443
| 11 22 44
S 80 + 1 1
U | 2 2
R | 11 4 4
V | 1 1 33
I 75 + 22
V | 3 3
A | 1 12 4 4
L | 3 3
70 + 11
| 22
|
| 121
65 +
|
|
| 1 1
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.