Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3789

TDMS Study 05142-03 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          T-BUTYL ALCOHOL


NTP Experiment-Test: 05142-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: DOSED WATER                                                                                                Time: 07:39:32




       Facility:  Southern Research Institute

       Chemical CAS #:  75-65-0

       Lock Date:  01/10/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            8            7            3                                     
    Moribund Sacrifice                                15           18           21           35                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           24           22           12                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Hyperplasia                                                        1 (2%)                                             
   Intestine Large, Colon                             (60)         (60)         (59)         (60)                                   
      Parasite Metazoan                                5 (8%)       3 (5%)       3 (5%)       5 (8%)                                
   Intestine Large, Rectum                            (59)         (59)         (59)         (60)                                   
      Edema                                                         1 (2%)                                                          
      Parasite Metazoan                               11 (19%)      8 (14%)      3 (5%)       6 (10%)                               
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Cecum                             (60)         (59)         (59)         (60)                                   
      Dilatation                                       1 (2%)       1 (2%)       1 (2%)                                             
      Edema                                                         1 (2%)                                                          
      Parasite Metazoan                                1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Intestine Small, Duodenum                          (60)         (60)         (59)         (60)                                   
      Erosion                                                                    3 (5%)       1 (2%)                                
   Intestine Small, Jejunum                           (60)         (59)         (59)         (60)                                   
      Dilatation                                       1 (2%)                                                                       
      Inflammation, Subacute                           1 (2%)                                                                       
      Mucosa, Hyperplasia, Diffuse                                               1 (2%)                                             
   Intestine Small, Ileum                             (60)         (59)         (59)         (60)                                   
      Inflammation, Subacute                           1 (2%)                                                                       
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      6 (10%)      5 (8%)       6 (10%)      4 (7%)                                
      Basophilic Focus                                45 (75%)     39 (65%)     36 (60%)     46 (77%)                               
      Clear Cell Focus                                10 (17%)      5 (8%)       4 (7%)       2 (3%)                                
      Congestion                                                    1 (2%)                                                          
      Eosinophilic Focus                                                         2 (3%)       1 (2%)                                
      Granuloma                                       13 (22%)     13 (22%)     13 (22%)     17 (28%)                               
      Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
      Hepatodiaphragmatic Nodule                      14 (23%)     16 (27%)     19 (32%)     15 (25%)                               
      Hyperplasia, Focal                               9 (15%)     11 (18%)     14 (23%)      5 (8%)                                
      Hyperplasia, Lymphoid                            3 (5%)       1 (2%)                    1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Subacute                          10 (17%)     16 (27%)      4 (7%)       6 (10%)                               
      Mixed Cell Focus                                 7 (12%)      9 (15%)      6 (10%)      2 (3%)                                
      Thrombosis                                                                              1 (2%)                                
      Bile Duct, Cyst                                  3 (5%)       1 (2%)                    1 (2%)                                
      Bile Duct, Hyperplasia                          14 (23%)     22 (37%)     16 (27%)     17 (28%)                               
      Centrilobular, Atrophy                           7 (12%)      9 (15%)      7 (12%)      7 (12%)                               
      Centrilobular, Necrosis                                       1 (2%)       2 (3%)       1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic           10 (17%)     13 (22%)     12 (20%)      7 (12%)                               
      Kupffer Cell, Hyperplasia                                                  1 (2%)       2 (3%)                                
      Kupffer Cell, Pigmentation                       3 (5%)       9 (15%)      5 (8%)       5 (8%)                                
      Lobules, Necrosis                                4 (7%)       4 (7%)       2 (3%)       7 (12%)                               
   Mesentery                                          (9)          (6)          (8)          (6)                                    
      Accessory Spleen                                 1 (11%)                                1 (17%)                               
      Fat, Necrosis                                    7 (78%)      6 (100%)     6 (75%)      5 (83%)                               
   Pancreas                                           (60)         (60)         (59)         (60)                                   
      Atrophy                                         17 (28%)     29 (48%)     23 (39%)     23 (38%)                               
      Cyst                                                          1 (2%)                    3 (5%)                                
      Ectopic Liver                                                                           1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Acinar Cell, Cytoplasmic Alteration              4 (7%)       1 (2%)       8 (14%)      9 (15%)                               
      Acinar Cell, Hyperplasia, Focal                               2 (3%)       1 (2%)                                             
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Atrophy                                          3 (5%)       2 (3%)       1 (2%)       3 (5%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Acinar Cell, Cytoplasmic Alteration              1 (2%)       4 (7%)       3 (5%)       5 (8%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                            4 (7%)       5 (8%)       8 (13%)      2 (3%)                                
      Erosion                                          1 (2%)       3 (5%)       1 (2%)                                             
      Fibrosis                                                                   4 (7%)       2 (3%)                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Perforation                                                                3 (5%)                                             
      Ulcer                                            5 (8%)       3 (5%)       9 (15%)      9 (15%)                               
      Mucosa, Hyperplasia                              8 (13%)      2 (3%)      16 (27%)     12 (20%)                               
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Edema                                            2 (3%)       3 (5%)       4 (7%)                                             
      Erosion                                          5 (8%)       4 (7%)       2 (3%)       8 (13%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            2 (3%)       1 (2%)       4 (7%)       3 (5%)                                
      Epithelium, Dilatation                           2 (3%)       3 (5%)       2 (3%)       5 (8%)                                
   Tongue                                                          (1)          (1)          (3)                                    
      Hyperplasia                                                                             1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Fibrosis                                                                   1 (100%)                                           
      Inflammation, Chronic Active                                               1 (100%)                                           
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  18 (30%)     15 (25%)     23 (38%)     12 (20%)                               
      Thrombosis                                                    1 (2%)       3 (5%)       1 (2%)                                
      Myocardium, Inflammation, Chronic                             1 (2%)                    2 (3%)                                
      Myocardium, Mineralization                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule               11 (18%)     11 (18%)      7 (12%)     15 (25%)                               
      Angiectasis                                      7 (12%)      4 (7%)       8 (13%)      4 (7%)                                
      Atrophy                                          2 (3%)                                                                       
      Basophilic Focus                                 1 (2%)                                 1 (2%)                                
      Congestion                                       1 (2%)       2 (3%)       1 (2%)       2 (3%)                                
      Cyst                                                          1 (2%)                                                          
      Hematopoietic Cell Proliferation                 4 (7%)       3 (5%)       4 (7%)                                             
      Hemorrhage                                                    2 (3%)                                                          
      Hyperplasia, Diffuse                                                                    2 (3%)                                
      Hyperplasia, Focal                               6 (10%)     14 (23%)      8 (13%)      9 (15%)                               
      Hypertrophy, Focal                               1 (2%)       2 (3%)       1 (2%)       3 (5%)                                
      Metaplasia, Osseous                              1 (2%)                                                                       
      Necrosis                                         1 (2%)                    1 (2%)                                             
      Pigmentation                                     2 (3%)       2 (3%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)       2 (3%)       2 (3%)       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                14 (23%)     12 (20%)     15 (25%)     13 (22%)                               
   Adrenal Medulla                                    (60)         (60)         (60)         (59)                                   
      Angiectasis                                                                2 (3%)                                             
      Hyperplasia                                      4 (7%)      10 (17%)      9 (15%)      4 (7%)                                
   Islets, Pancreatic                                 (60)         (60)         (58)         (60)                                   
      Hyperplasia                                      3 (5%)       1 (2%)       2 (3%)       2 (3%)                                
   Parathyroid Gland                                  (57)         (60)         (57)         (60)                                   
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                      1 (2%)                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (59)         (59)                                   
      Hypertrophy, Focal                                                         1 (2%)                                             
      Pigmentation                                     2 (3%)       2 (3%)       3 (5%)       6 (10%)                               
      Pars Distalis, Angiectasis                      11 (18%)     10 (17%)     11 (19%)      6 (10%)                               
      Pars Distalis, Atrophy                           1 (2%)                                                                       
      Pars Distalis, Cyst                             23 (38%)     19 (32%)     23 (39%)     19 (32%)                               
      Pars Distalis, Hyperplasia                      16 (27%)     11 (18%)     21 (36%)     18 (31%)                               
      Pars Distalis, Infiltration Cellular,                                                                                         
          Histiocyte                                                                          1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Angiectasis                     4 (7%)       2 (3%)       1 (2%)       3 (5%)                                
      Pars Intermedia, Cyst                            5 (8%)       6 (10%)      2 (3%)       3 (5%)                                
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Intermedia, Hypertrophy, Focal                                        1 (2%)                                             
   Thyroid Gland                                      (59)         (60)         (60)         (60)                                   
      Degeneration, Cystic                                                       1 (2%)       2 (3%)                                
      Ultimobranchial Cyst                             1 (2%)       3 (5%)       2 (3%)       3 (5%)                                
      C-Cell, Hyperplasia                             21 (36%)     17 (28%)     13 (22%)     13 (22%)                               
      Follicle, Cyst                                   1 (2%)       2 (3%)       2 (3%)       6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (60)         (60)         (60)                                   
      Ectasia                                          1 (2%)       2 (3%)       1 (2%)                                             
      Hyperplasia                                      4 (7%)       4 (7%)       4 (7%)       4 (7%)                                
      Inflammation, Chronic                            8 (14%)      3 (5%)       3 (5%)       2 (3%)                                
      Inflammation, Suppurative                        4 (7%)       2 (3%)                    1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Cyst                                            12 (20%)     14 (23%)     17 (28%)     17 (28%)                               
      Mineralization                                                1 (2%)                                                          
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Hydrometra                                       4 (7%)       3 (5%)       2 (3%)       5 (8%)                                
      Hyperplasia, Cystic                              2 (3%)       2 (3%)       5 (8%)       1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Pigmentation                                     1 (2%)                    1 (2%)       3 (5%)                                
      Prolapse                                                                   1 (2%)                                             
      Endometrium, Fibrosis                                                      1 (2%)                                             
   Vagina                                             (3)          (3)          (6)          (6)                                    
      Cyst                                                                                    1 (17%)                               
      Exudate                                                       1 (33%)      2 (33%)      1 (17%)                               
      Hyperplasia                                                                             1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Congestion                                                                 1 (2%)       1 (2%)                                
      Hypercellularity                                              2 (3%)       3 (5%)       1 (2%)                                
      Myelofibrosis                                    4 (7%)      11 (18%)      3 (5%)       5 (8%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node                                         (14)         (15)         (12)         (7)                                    
      Mediastinal, Hemorrhage                          2 (14%)      1 (7%)       5 (42%)                                            
      Mediastinal, Hyperplasia, Histiocytic            1 (7%)                                                                       
      Mediastinal, Pigmentation                        2 (14%)      3 (20%)      3 (25%)                                            
      Pancreatic, Hemorrhage                                        1 (7%)       3 (25%)                                            
      Pancreatic, Hyperplasia, Lymphoid                1 (7%)                                                                       
      Pancreatic, Pigmentation                         1 (7%)                    1 (8%)                                             
      Renal, Hemorrhage                                             1 (7%)                                                          
      Renal, Pigmentation                                           1 (7%)                                                          
   Lymph Node, Mandibular                             (60)         (59)         (60)         (59)                                   
      Ectasia                                          4 (7%)       5 (8%)       8 (13%)      2 (3%)                                
      Hemorrhage                                       1 (2%)       2 (3%)       3 (5%)       2 (3%)                                
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            3 (5%)       3 (5%)       1 (2%)       4 (7%)                                
      Hyperplasia, Plasma Cell                         7 (12%)      8 (14%)     10 (17%)     12 (20%)                               
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Pigmentation                                     3 (5%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (59)         (60)         (60)                                   
      Ectasia                                          1 (2%)                                 1 (2%)                                
      Hemorrhage                                       3 (5%)       3 (5%)       8 (13%)      3 (5%)                                
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (3%)       5 (8%)       2 (3%)                                             
      Hyperplasia, Plasma Cell                         2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Mast Cell                              1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Developmental Malformation                       1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis                                         4 (7%)       5 (8%)       3 (5%)       5 (8%)                                
      Hematopoietic Cell Proliferation                19 (32%)     19 (32%)     17 (28%)     16 (27%)                               
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Necrosis                                         2 (3%)                                                                       
      Pigmentation                                    44 (73%)     42 (70%)     42 (70%)     44 (73%)                               
      Lymphoid Follicle, Atrophy                       1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Red Pulp, Atrophy                                                          1 (2%)       2 (3%)                                
   Thymus                                             (58)         (57)         (59)         (58)                                   
      Congestion                                       1 (2%)       1 (2%)       2 (3%)                                             
      Cyst                                             1 (2%)       1 (2%)                    1 (2%)                                
      Ectopic Parathyroid Gland                                                               1 (2%)                                
      Hemorrhage                                                                 2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (59)         (60)         (60)                                   
      Hyperplasia, Cystic                             41 (68%)     47 (80%)     45 (75%)     51 (85%)                               
      Hyperplasia, Lobular                             5 (8%)       7 (12%)      5 (8%)       6 (10%)                               
   Skin                                               (60)         (60)         (59)         (60)                                   
      Acanthosis                                       3 (5%)                                 4 (7%)                                
      Exudate                                          2 (3%)                                 1 (2%)                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Ulcer                                                                                   2 (3%)                                
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Developmental Malformation                                    1 (2%)                                                          
      Fibrous Osteodystrophy                                        1 (2%)       4 (7%)       5 (8%)                                
      Calvarium, Osteopetrosis                        20 (33%)      9 (15%)     11 (18%)     10 (17%)                               
      Femur, Osteopetrosis                            12 (20%)      7 (12%)      4 (7%)       8 (13%)                               
      Sternum, Osteopetrosis                          12 (20%)      8 (13%)      4 (7%)       8 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                     16 (27%)     13 (22%)     12 (20%)     10 (17%)                               
      Developmental Malformation                       1 (2%)       1 (2%)                    1 (2%)                                
      Hemorrhage                                                                              2 (3%)                                
      Hydrocephalus                                    3 (5%)       6 (10%)      1 (2%)       4 (7%)                                
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
   Spinal Cord                                                                  (1)                                                 
      Hemorrhage                                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)       4 (7%)       4 (7%)       1 (2%)                                
      Edema                                                         3 (5%)                                                          
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       2 (3%)       2 (3%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               24 (40%)     19 (32%)     22 (37%)     17 (28%)                               
      Inflammation, Subacute                           1 (2%)       3 (5%)       2 (3%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Leukocytosis                                                               1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 4 (7%)       2 (3%)       4 (7%)       2 (3%)                                
      Bronchiole, Epithelium, Hyperplasia                                        1 (2%)                                             
   Nose                                               (60)         (60)         (60)         (60)                                   
      Exudate                                          7 (12%)     11 (18%)     15 (25%)     15 (25%)                               
      Foreign Body                                     3 (5%)       3 (5%)       5 (8%)       7 (12%)                               
      Fungus                                           4 (7%)       2 (3%)       5 (8%)       9 (15%)                               
      Glands, Hyperplasia                              1 (2%)       1 (2%)                                                          
      Mucosa, Hyperplasia                              7 (12%)      4 (7%)       8 (13%)      8 (13%)                               
      Mucosa, Metaplasia, Squamous                     4 (7%)       3 (5%)       4 (7%)       7 (12%)                               
      Mucosa, Necrosis                                                           1 (2%)       2 (3%)                                
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Mucosa, Hyperplasia                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (5)          (5)          (5)                                    
      Cataract                                         2 (100%)     4 (80%)      5 (100%)     4 (80%)                               
      Hemorrhage                                                                              1 (20%)                               
      Retina, Atrophy                                  2 (100%)     4 (80%)      5 (100%)     4 (80%)                               
   Lacrimal Gland                                                               (1)                                                 
      Ectopic Harderian                                                          1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Inflammation, Suppurative                        2 (3%)       3 (5%)      13 (22%)     17 (28%)                               
      Mineralization                                  59 (98%)     60 (100%)    60 (100%)    60 (100%)                              
      Nephropathy                                     58 (97%)     57 (95%)     58 (97%)     60 (100%)                              
      Interstitial Tissue, Pigmentation                1 (2%)       1 (2%)                    1 (2%)                                
      Renal Tubule, Cytoplasmic Alteration             5 (8%)       4 (7%)       3 (5%)       4 (7%)                                
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
      Renal Tubule, Pigmentation                      10 (17%)     12 (20%)      6 (10%)      5 (8%)                                
      Transitional Epithelium, Hyperplasia                                       3 (5%)      17 (28%)                               
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Dilatation                                                                 2 (3%)                                             
      Hemorrhage                                                                 2 (3%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Mucosa, Hyperplasia                              1 (2%)       1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                31           35           41           46                                     
    Natural Death                                      9            9            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            6            4            1                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (59)         (60)         (60)                                   
      Parasite Metazoan                                5 (8%)       4 (7%)       4 (7%)       5 (8%)                                
   Intestine Large, Rectum                            (59)         (58)         (59)         (60)                                   
      Parasite Metazoan                                6 (10%)      7 (12%)      6 (10%)      6 (10%)                               
   Intestine Large, Cecum                             (60)         (59)         (60)         (60)                                   
      Dilatation                                       1 (2%)       1 (2%)                    1 (2%)                                
      Edema                                            1 (2%)                                 1 (2%)                                
      Erosion                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Parasite Metazoan                                2 (3%)                                 1 (2%)                                
   Intestine Small, Duodenum                          (58)         (53)         (55)         (60)                                   
      Ectopic Tissue                                                             1 (2%)                                             
      Erosion                                          2 (3%)       3 (6%)       8 (15%)      4 (7%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
      Mucosa, Hyperplasia, Diffuse                                  1 (2%)                    2 (3%)                                
   Intestine Small, Jejunum                           (60)         (57)         (60)         (60)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Subacute                                        1 (2%)                                                          
      Mucosa, Hyperplasia, Diffuse                     3 (5%)       3 (5%)       4 (7%)       1 (2%)                                
   Intestine Small, Ileum                             (60)         (58)         (59)         (60)                                   
      Dilatation                                       1 (2%)                                 1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Subacute                                        1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mucosa, Hyperplasia, Diffuse                                  1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      3 (5%)       2 (3%)       6 (10%)      4 (7%)                                
      Basophilic Focus                                13 (22%)     19 (32%)     24 (40%)     18 (30%)                               
      Clear Cell Focus                                 6 (10%)      4 (7%)       3 (5%)       5 (8%)                                
      Congestion                                       1 (2%)       2 (3%)       2 (3%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Degeneration, Cystic                            11 (18%)      8 (13%)      8 (13%)      6 (10%)                               
      Eosinophilic Focus                               2 (3%)       3 (5%)                    3 (5%)                                
      Granuloma                                        3 (5%)       3 (5%)       6 (10%)      2 (3%)                                
      Hematopoietic Cell Proliferation                 3 (5%)       3 (5%)                    2 (3%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hepatodiaphragmatic Nodule                      10 (17%)      8 (13%)      6 (10%)      3 (5%)                                
      Hyperplasia, Focal                               9 (15%)      7 (12%)      4 (7%)       6 (10%)                               
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Inflammation, Subacute                           1 (2%)       3 (5%)       4 (7%)       4 (7%)                                
      Mixed Cell Focus                                 6 (10%)      3 (5%)       3 (5%)       3 (5%)                                
      Thrombosis                                                    1 (2%)                                                          
      Bile Duct, Cyst                                  1 (2%)                    1 (2%)       1 (2%)                                
      Bile Duct, Hyperplasia                          48 (80%)     49 (82%)     47 (78%)     55 (92%)                               
      Centrilobular, Atrophy                           9 (15%)     12 (20%)      7 (12%)     16 (27%)                               
      Centrilobular, Necrosis                                       1 (2%)       2 (3%)       2 (3%)                                
      Hepatocyte, Vacuolization Cytoplasmic           16 (27%)     14 (23%)     13 (22%)      4 (7%)                                
      Kupffer Cell, Pigmentation                       3 (5%)       8 (13%)      4 (7%)       2 (3%)                                
      Lobules, Necrosis                                4 (7%)       7 (12%)      3 (5%)       1 (2%)                                
   Mesentery                                          (5)          (7)          (9)          (3)                                    
      Accessory Spleen                                                           1 (11%)      1 (33%)                               
      Hemorrhage                                                    1 (14%)                                                         
      Fat, Hemorrhage                                  1 (20%)                                                                      
      Fat, Necrosis                                    5 (100%)     5 (71%)      4 (44%)      1 (33%)                               
   Pancreas                                           (60)         (59)         (60)         (60)                                   
      Atrophy                                         34 (57%)     37 (63%)     33 (55%)     25 (42%)                               
      Cyst                                             1 (2%)                                 3 (5%)                                
      Fibrosis                                         1 (2%)                                                                       
      Focal Cellular Change                            1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
      Acinar Cell, Cytoplasmic Alteration              8 (13%)     11 (19%)     13 (22%)     11 (18%)                               
      Acinar Cell, Hyperplasia, Focal                 10 (17%)      5 (8%)       7 (12%)      1 (2%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Atrophy                                          2 (3%)       2 (3%)       2 (3%)       2 (3%)                                
      Acinar Cell, Cytoplasmic Alteration              5 (8%)       5 (8%)       4 (7%)       4 (7%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                            4 (7%)       7 (12%)      4 (7%)       2 (3%)                                
      Erosion                                          2 (3%)       1 (2%)       1 (2%)       2 (3%)                                
      Fibrosis                                                      3 (5%)       1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Subacute                           2 (3%)       1 (2%)                    1 (2%)                                
      Perforation                                                   1 (2%)                                                          
      Ulcer                                            7 (12%)     14 (23%)      9 (15%)      3 (5%)                                
      Mucosa, Hyperplasia                             12 (20%)     16 (27%)     10 (17%)      7 (12%)                               
   Stomach, Glandular                                 (60)         (59)         (60)         (60)                                   
      Cyst Epithelial Inclusion                        1 (2%)       1 (2%)                                                          
      Edema                                            6 (10%)      2 (3%)       5 (8%)       3 (5%)                                
      Erosion                                         11 (18%)      5 (8%)       6 (10%)      6 (10%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                            1 (2%)       3 (5%)                                                          
      Mineralization                                   4 (7%)       3 (5%)       2 (3%)       2 (3%)                                
      Ulcer                                            2 (3%)       3 (5%)       7 (12%)      2 (3%)                                
      Epithelium, Dilatation                                        2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (6)          (3)          (1)          (1)                                    
      Hypertrophy                                      2 (33%)                                1 (100%)                              
      Inflammation, Chronic Active                     6 (100%)     3 (100%)     1 (100%)     1 (100%)                              
      Thrombosis                                                                              1 (100%)                              
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  26 (43%)     30 (50%)     29 (48%)     28 (47%)                               
      Thrombosis                                       1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Myocardium, Inflammation, Chronic                                                       1 (2%)                                
      Myocardium, Mineralization                       1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule               14 (23%)     17 (28%)     15 (25%)     14 (23%)                               
      Atrophy                                          1 (2%)                                                                       
      Basophilic Focus                                              2 (3%)                    1 (2%)                                
      Congestion                                       1 (2%)       1 (2%)                                                          
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Diffuse                             1 (2%)                                                                       
      Hyperplasia, Focal                               6 (10%)      5 (8%)       7 (12%)      4 (7%)                                
      Hypertrophy, Focal                               4 (7%)       1 (2%)       2 (3%)                                             
      Necrosis                                                                                1 (2%)                                
      Pigmentation                                     3 (5%)       3 (5%)       1 (2%)       2 (3%)                                
      Vacuolization Cytoplasmic, Diffuse               6 (10%)      6 (10%)      4 (7%)       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                16 (27%)      9 (15%)     17 (28%)     15 (25%)                               
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                     22 (37%)     21 (35%)     23 (38%)     15 (25%)                               
   Islets, Pancreatic                                 (60)         (59)         (59)         (59)                                   
      Hyperplasia                                      5 (8%)       2 (3%)       3 (5%)       4 (7%)                                
   Parathyroid Gland                                  (60)         (56)         (59)         (58)                                   
      Hyperplasia                                      8 (13%)      9 (16%)     13 (22%)      6 (10%)                               
   Pituitary Gland                                    (59)         (60)         (59)         (58)                                   
      Inflammation, Suppurative                                     1 (2%)                                                          
      Pigmentation                                                                            2 (3%)                                
      Pars Distalis, Angiectasis                       2 (3%)       1 (2%)       3 (5%)       4 (7%)                                
      Pars Distalis, Cyst                              4 (7%)       4 (7%)       2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia                       9 (15%)      7 (12%)      9 (15%)     13 (22%)                               
      Pars Distalis, Necrosis                                       1 (2%)                                                          
      Pars Intermedia, Angiectasis                     1 (2%)       1 (2%)                                                          
      Pars Intermedia, Cyst                            2 (3%)       2 (3%)       1 (2%)       3 (5%)                                
      Pars Nervosa, Hyperplasia                        4 (7%)       4 (7%)       4 (7%)      11 (19%)                               
   Thyroid Gland                                      (60)         (59)         (60)         (60)                                   
      Degeneration, Cystic                             4 (7%)       1 (2%)                    3 (5%)                                
      Hypoplasia                                                                              1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (2%)                                             
      Ultimobranchial Cyst                                          2 (3%)       1 (2%)       2 (3%)                                
      C-Cell, Hyperplasia                             11 (18%)      9 (15%)      2 (3%)       3 (5%)                                
      Follicle, Cyst                                   7 (12%)      2 (3%)       6 (10%)      7 (12%)                               
      Follicular Cell, Hyperplasia                     4 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Atypia Cellular                                 15 (25%)      9 (15%)     11 (18%)     10 (17%)                               
      Hypospermia                                     26 (43%)     22 (37%)     19 (32%)     23 (38%)                               
   Penis                                                           (2)          (1)                                                 
      Edema                                                         1 (50%)                                                         
      Inflammation, Suppurative                                     2 (100%)     1 (100%)                                           
   Preputial Gland                                    (60)         (60)         (60)         (59)                                   
      Ectasia                                          2 (3%)       3 (5%)       1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                           23 (38%)     26 (43%)     23 (38%)     27 (46%)                               
      Inflammation, Suppurative                        7 (12%)      5 (8%)       5 (8%)       6 (10%)                               
      Necrosis                                                      1 (2%)                                                          
   Prostate                                           (60)         (60)         (60)         (60)                                   
      Corpora Amylacea                                 7 (12%)      7 (12%)      9 (15%)      7 (12%)                               
      Ectasia                                          4 (7%)       1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis                                         3 (5%)       4 (7%)       3 (5%)       3 (5%)                                
      Hyperplasia, Lymphoid                           11 (18%)      8 (13%)      9 (15%)      8 (13%)                               
      Inflammation, Suppurative                       52 (87%)     48 (80%)     46 (77%)     37 (62%)                               
      Epithelium, Hyperplasia                          2 (3%)                    2 (3%)       2 (3%)                                
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
      Depletion Cellular                                                                      1 (2%)                                
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       1 (2%)                                
   Testes                                             (60)         (60)         (60)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Mineralization                                   2 (3%)                    1 (2%)                                             
      Spermatocele                                     1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                  11 (18%)     20 (33%)     11 (18%)     20 (33%)                               
      Seminiferous Tubule, Atrophy                    14 (23%)     18 (30%)     10 (17%)     13 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)                                                                       
      Hypercellularity                                              1 (2%)       4 (7%)       2 (3%)                                
      Myelofibrosis                                    4 (7%)       4 (7%)       2 (3%)       4 (7%)                                
   Lymph Node                                         (19)         (11)         (15)         (20)                                   
      Inguinal, Hyperplasia, Plasma Cell                                                      1 (5%)                                
      Lumbar, Hyperplasia, Plasma Cell                              1 (9%)                                                          
      Mediastinal, Hemorrhage                          3 (16%)      1 (9%)       3 (20%)      2 (10%)                               
      Mediastinal, Hyperplasia, Lymphoid                                                      1 (5%)                                
      Mediastinal, Hyperplasia, Plasma Cell            1 (5%)                    1 (7%)                                             
      Mediastinal, Necrosis                                                      1 (7%)                                             
      Mediastinal, Pigmentation                        1 (5%)                                                                       
      Pancreatic, Ectasia                              1 (5%)                                                                       
      Pancreatic, Hemorrhage                                                                  1 (5%)                                
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (5%)                                
      Pancreatic, Pigmentation                                      1 (9%)                                                          
      Renal, Hemorrhage                                1 (5%)       1 (9%)                                                          
      Renal, Hyperplasia, Plasma Cell                               1 (9%)                                                          
      Renal, Pigmentation                              1 (5%)                                                                       
   Lymph Node, Mandibular                             (60)         (58)         (59)         (60)                                   
      Congestion                                                                 1 (2%)                                             
      Ectasia                                          5 (8%)       9 (16%)      4 (7%)       7 (12%)                               
      Fibrosis                                                      1 (2%)                    1 (2%)                                
      Hemorrhage                                       4 (7%)       6 (10%)      2 (3%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       3 (5%)       8 (14%)      3 (5%)                                
      Hyperplasia, Plasma Cell                        15 (25%)     19 (33%)     11 (19%)     11 (18%)                               
      Inflammation, Suppurative                        1 (2%)                                                                       
   Lymph Node, Mesenteric                             (59)         (59)         (60)         (60)                                   
      Ectasia                                          1 (2%)       1 (2%)       2 (3%)                                             
      Hemorrhage                                       3 (5%)       4 (7%)       1 (2%)       5 (8%)                                
      Hyperplasia, Lymphoid                            2 (3%)       4 (7%)       6 (10%)      1 (2%)                                
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
      Pigmentation                                                  2 (3%)                                                          
   Spleen                                             (60)         (59)         (60)         (60)                                   
      Congestion                                                    1 (2%)                                                          
      Developmental Malformation                       2 (3%)       1 (2%)       1 (2%)                                             
      Fibrosis                                        11 (18%)     17 (29%)     14 (23%)     14 (23%)                               
      Hematopoietic Cell Proliferation                 9 (15%)     12 (20%)     12 (20%)     12 (20%)                               
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis                                         3 (5%)       2 (3%)       1 (2%)       1 (2%)                                
      Pigmentation                                    21 (35%)     35 (59%)     23 (38%)     25 (42%)                               
      Lymphoid Follicle, Atrophy                       2 (3%)       2 (3%)                                                          
      Red Pulp, Atrophy                                2 (3%)       1 (2%)                                                          
   Thymus                                             (54)         (59)         (57)         (56)                                   
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                                    3 (5%)                                
      Ectopic Parathyroid Gland                                                               1 (2%)                                
      Ectopic Thyroid                                               1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Epithelial Cell, Hyperplasia                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (58)         (57)         (56)                                   
      Hyperplasia, Cystic                             26 (48%)     30 (52%)     27 (47%)     16 (29%)                               
      Hyperplasia, Lobular                             2 (4%)       2 (3%)                                                          
   Skin                                               (60)         (60)         (59)         (60)                                   
      Acanthosis                                       4 (7%)       3 (5%)       2 (3%)       2 (3%)                                
      Cyst Epithelial Inclusion                        1 (2%)       1 (2%)       1 (2%)                                             
      Exudate                                          2 (3%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fibrous Osteodystrophy                          10 (17%)     14 (23%)     16 (27%)     10 (17%)                               
      Hyperostosis                                                  2 (3%)                    1 (2%)                                
      Necrosis                                                      1 (2%)                    1 (2%)                                
      Femur, Osteopetrosis                             1 (2%)                                 1 (2%)                                
      Sternum, Osteopetrosis                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                     19 (32%)     18 (30%)     19 (32%)      6 (10%)                               
      Granuloma                                                                  1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Hydrocephalus                                    6 (10%)     10 (17%)     12 (20%)      5 (8%)                                
      Mineralization                                                1 (2%)                    2 (3%)                                
      Necrosis                                                                                3 (5%)                                
      Vacuolization Cytoplasmic                        1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       4 (7%)       1 (2%)       4 (7%)                                             
      Edema                                                         1 (2%)                                                          
      Foreign Body                                                  1 (2%)                    1 (2%)                                
      Hemorrhage                                                    2 (3%)       2 (3%)       2 (3%)                                
      Hyperplasia, Lymphoid                                         3 (5%)       2 (3%)                                             
      Infiltration Cellular, Histiocyte               15 (25%)     12 (20%)     12 (20%)     15 (25%)                               
      Inflammation, Subacute                           2 (3%)       5 (8%)       7 (12%)      2 (3%)                                
      Inflammation, Suppurative                                     2 (3%)                    1 (2%)                                
      Leukocytosis                                                               1 (2%)                                             
      Metaplasia, Osseous                              2 (3%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 6 (10%)      2 (3%)       6 (10%)      5 (8%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Exudate                                         30 (50%)     26 (43%)     34 (57%)     24 (40%)                               
      Foreign Body                                    16 (27%)     17 (28%)     18 (30%)     12 (20%)                               
      Fungus                                          17 (28%)     17 (28%)     22 (37%)     14 (23%)                               
      Mucosa, Hyperplasia                             25 (42%)     24 (40%)     24 (40%)     21 (35%)                               
      Mucosa, Metaplasia, Squamous                     6 (10%)      9 (15%)      9 (15%)      7 (12%)                               
      Mucosa, Necrosis                                              2 (3%)                    4 (7%)                                
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Mucosa, Hyperplasia                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (3)          (2)          (3)                                    
      Cataract                                         4 (100%)     3 (100%)     1 (50%)      3 (100%)                              
      Inflammation, Chronic                                         1 (33%)                                                         
      Retina, Atrophy                                  4 (100%)     3 (100%)                  3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                                                                    1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hydronephrosis                                                1 (2%)                    1 (2%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Suppurative                       10 (17%)     18 (30%)     12 (20%)      9 (15%)                               
      Mineralization                                  27 (45%)     30 (50%)     40 (67%)     57 (95%)                               
      Nephropathy                                     59 (98%)     59 (98%)     60 (100%)    60 (100%)                              
      Thrombosis                                                                              1 (2%)                                
      Interstitial Tissue, Pigmentation                                                       1 (2%)                                
      Renal Tubule, Cytoplasmic Alteration                                       1 (2%)                                             
      Renal Tubule, Hyperplasia                        3 (5%)       7 (12%)      6 (10%)      6 (10%)                               
      Renal Tubule, Hyperplasia, Oncocytic                                       2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Pigmentation                       7 (12%)      9 (15%)      6 (10%)     12 (20%)                               
      Transitional Epithelium, Hyperplasia            25 (42%)     32 (53%)     36 (60%)     40 (67%)                               
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Angiectasis                                                                1 (2%)                                             
      Dilatation                                       2 (3%)                    2 (3%)       2 (3%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Subacute                                                     1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       2 (3%)                                                          
      Mucosa, Hyperplasia                                                        3 (5%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------