National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3789

TDMS Study 05142-03 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          T-BUTYL ALCOHOL


NTP Experiment-Test: 05142-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: DOSED WATER                                                                                                Time: 07:39:32




       Facility:  Southern Research Institute

       Chemical CAS #:  75-65-0

       Lock Date:  01/10/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            8            7            3                                     
    Moribund Sacrifice                                15           18           21           35                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           24           22           12                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Hyperplasia                                                        1 (2%)                                             
   Intestine Large, Colon                             (60)         (60)         (59)         (60)                                   
      Parasite Metazoan                                5 (8%)       3 (5%)       3 (5%)       5 (8%)                                
   Intestine Large, Rectum                            (59)         (59)         (59)         (60)                                   
      Edema                                                         1 (2%)                                                          
      Parasite Metazoan                               11 (19%)      8 (14%)      3 (5%)       6 (10%)                               
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Cecum                             (60)         (59)         (59)         (60)                                   
      Dilatation                                       1 (2%)       1 (2%)       1 (2%)                                             
      Edema                                                         1 (2%)                                                          
      Parasite Metazoan                                1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Intestine Small, Duodenum                          (60)         (60)         (59)         (60)                                   
      Erosion                                                                    3 (5%)       1 (2%)                                
   Intestine Small, Jejunum                           (60)         (59)         (59)         (60)                                   
      Dilatation                                       1 (2%)                                                                       
      Inflammation, Subacute                           1 (2%)                                                                       
      Mucosa, Hyperplasia, Diffuse                                               1 (2%)                                             
   Intestine Small, Ileum                             (60)         (59)         (59)         (60)                                   
      Inflammation, Subacute                           1 (2%)                                                                       
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      6 (10%)      5 (8%)       6 (10%)      4 (7%)                                
      Basophilic Focus                                45 (75%)     39 (65%)     36 (60%)     46 (77%)                               
      Clear Cell Focus                                10 (17%)      5 (8%)       4 (7%)       2 (3%)                                
      Congestion                                                    1 (2%)                                                          
      Eosinophilic Focus                                                         2 (3%)       1 (2%)                                
      Granuloma                                       13 (22%)     13 (22%)     13 (22%)     17 (28%)                               
      Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
      Hepatodiaphragmatic Nodule                      14 (23%)     16 (27%)     19 (32%)     15 (25%)                               
      Hyperplasia, Focal                               9 (15%)     11 (18%)     14 (23%)      5 (8%)                                
      Hyperplasia, Lymphoid                            3 (5%)       1 (2%)                    1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Subacute                          10 (17%)     16 (27%)      4 (7%)       6 (10%)                               
      Mixed Cell Focus                                 7 (12%)      9 (15%)      6 (10%)      2 (3%)                                
      Thrombosis                                                                              1 (2%)                                
      Bile Duct, Cyst                                  3 (5%)       1 (2%)                    1 (2%)                                
      Bile Duct, Hyperplasia                          14 (23%)     22 (37%)     16 (27%)     17 (28%)                               
      Centrilobular, Atrophy                           7 (12%)      9 (15%)      7 (12%)      7 (12%)                               
      Centrilobular, Necrosis                                       1 (2%)       2 (3%)       1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic           10 (17%)     13 (22%)     12 (20%)      7 (12%)                               
      Kupffer Cell, Hyperplasia                                                  1 (2%)       2 (3%)                                
      Kupffer Cell, Pigmentation                       3 (5%)       9 (15%)      5 (8%)       5 (8%)                                
      Lobules, Necrosis                                4 (7%)       4 (7%)       2 (3%)       7 (12%)                               
   Mesentery                                          (9)          (6)          (8)          (6)                                    
      Accessory Spleen                                 1 (11%)                                1 (17%)                               
      Fat, Necrosis                                    7 (78%)      6 (100%)     6 (75%)      5 (83%)                               
   Pancreas                                           (60)         (60)         (59)         (60)                                   
      Atrophy                                         17 (28%)     29 (48%)     23 (39%)     23 (38%)                               
      Cyst                                                          1 (2%)                    3 (5%)                                
      Ectopic Liver                                                                           1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Acinar Cell, Cytoplasmic Alteration              4 (7%)       1 (2%)       8 (14%)      9 (15%)                               
      Acinar Cell, Hyperplasia, Focal                               2 (3%)       1 (2%)                                             
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Atrophy                                          3 (5%)       2 (3%)       1 (2%)       3 (5%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Acinar Cell, Cytoplasmic Alteration              1 (2%)       4 (7%)       3 (5%)       5 (8%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                            4 (7%)       5 (8%)       8 (13%)      2 (3%)                                
      Erosion                                          1 (2%)       3 (5%)       1 (2%)                                             
      Fibrosis                                                                   4 (7%)       2 (3%)                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Perforation                                                                3 (5%)                                             
      Ulcer                                            5 (8%)       3 (5%)       9 (15%)      9 (15%)                               
      Mucosa, Hyperplasia                              8 (13%)      2 (3%)      16 (27%)     12 (20%)                               
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Edema                                            2 (3%)       3 (5%)       4 (7%)                                             
      Erosion                                          5 (8%)       4 (7%)       2 (3%)       8 (13%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            2 (3%)       1 (2%)       4 (7%)       3 (5%)                                
      Epithelium, Dilatation                           2 (3%)       3 (5%)       2 (3%)       5 (8%)                                
   Tongue                                                          (1)          (1)          (3)                                    
      Hyperplasia                                                                             1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Fibrosis                                                                   1 (100%)                                           
      Inflammation, Chronic Active                                               1 (100%)                                           
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  18 (30%)     15 (25%)     23 (38%)     12 (20%)                               
      Thrombosis                                                    1 (2%)       3 (5%)       1 (2%)                                
      Myocardium, Inflammation, Chronic                             1 (2%)                    2 (3%)                                
      Myocardium, Mineralization                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule               11 (18%)     11 (18%)      7 (12%)     15 (25%)                               
      Angiectasis                                      7 (12%)      4 (7%)       8 (13%)      4 (7%)                                
      Atrophy                                          2 (3%)                                                                       
      Basophilic Focus                                 1 (2%)                                 1 (2%)                                
      Congestion                                       1 (2%)       2 (3%)       1 (2%)       2 (3%)                                
      Cyst                                                          1 (2%)                                                          
      Hematopoietic Cell Proliferation                 4 (7%)       3 (5%)       4 (7%)                                             
      Hemorrhage                                                    2 (3%)                                                          
      Hyperplasia, Diffuse                                                                    2 (3%)                                
      Hyperplasia, Focal                               6 (10%)     14 (23%)      8 (13%)      9 (15%)                               
      Hypertrophy, Focal                               1 (2%)       2 (3%)       1 (2%)       3 (5%)                                
      Metaplasia, Osseous                              1 (2%)                                                                       
      Necrosis                                         1 (2%)                    1 (2%)                                             
      Pigmentation                                     2 (3%)       2 (3%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)       2 (3%)       2 (3%)       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                14 (23%)     12 (20%)     15 (25%)     13 (22%)                               
   Adrenal Medulla                                    (60)         (60)         (60)         (59)                                   
      Angiectasis                                                                2 (3%)                                             
      Hyperplasia                                      4 (7%)      10 (17%)      9 (15%)      4 (7%)                                
   Islets, Pancreatic                                 (60)         (60)         (58)         (60)                                   
      Hyperplasia                                      3 (5%)       1 (2%)       2 (3%)       2 (3%)                                
   Parathyroid Gland                                  (57)         (60)         (57)         (60)                                   
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                      1 (2%)                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (59)         (59)                                   
      Hypertrophy, Focal                                                         1 (2%)                                             
      Pigmentation                                     2 (3%)       2 (3%)       3 (5%)       6 (10%)                               
      Pars Distalis, Angiectasis                      11 (18%)     10 (17%)     11 (19%)      6 (10%)                               
      Pars Distalis, Atrophy                           1 (2%)                                                                       
      Pars Distalis, Cyst                             23 (38%)     19 (32%)     23 (39%)     19 (32%)                               
      Pars Distalis, Hyperplasia                      16 (27%)     11 (18%)     21 (36%)     18 (31%)                               
      Pars Distalis, Infiltration Cellular,                                                                                         
          Histiocyte                                                                          1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Angiectasis                     4 (7%)       2 (3%)       1 (2%)       3 (5%)                                
      Pars Intermedia, Cyst                            5 (8%)       6 (10%)      2 (3%)       3 (5%)                                
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Intermedia, Hypertrophy, Focal                                        1 (2%)                                             
   Thyroid Gland                                      (59)         (60)         (60)         (60)                                   
      Degeneration, Cystic                                                       1 (2%)       2 (3%)                                
      Ultimobranchial Cyst                             1 (2%)       3 (5%)       2 (3%)       3 (5%)                                
      C-Cell, Hyperplasia                             21 (36%)     17 (28%)     13 (22%)     13 (22%)                               
      Follicle, Cyst                                   1 (2%)       2 (3%)       2 (3%)       6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (60)         (60)         (60)                                   
      Ectasia                                          1 (2%)       2 (3%)       1 (2%)                                             
      Hyperplasia                                      4 (7%)       4 (7%)       4 (7%)       4 (7%)                                
      Inflammation, Chronic                            8 (14%)      3 (5%)       3 (5%)       2 (3%)                                
      Inflammation, Suppurative                        4 (7%)       2 (3%)                    1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Cyst                                            12 (20%)     14 (23%)     17 (28%)     17 (28%)                               
      Mineralization                                                1 (2%)                                                          
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Hydrometra                                       4 (7%)       3 (5%)       2 (3%)       5 (8%)                                
      Hyperplasia, Cystic                              2 (3%)       2 (3%)       5 (8%)       1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Pigmentation                                     1 (2%)                    1 (2%)       3 (5%)                                
      Prolapse                                                                   1 (2%)                                             
      Endometrium, Fibrosis                                                      1 (2%)                                             
   Vagina                                             (3)          (3)          (6)          (6)                                    
      Cyst                                                                                    1 (17%)                               
      Exudate                                                       1 (33%)      2 (33%)      1 (17%)                               
      Hyperplasia                                                                             1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Congestion                                                                 1 (2%)       1 (2%)                                
      Hypercellularity                                              2 (3%)       3 (5%)       1 (2%)                                
      Myelofibrosis                                    4 (7%)      11 (18%)      3 (5%)       5 (8%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node                                         (14)         (15)         (12)         (7)                                    
      Mediastinal, Hemorrhage                          2 (14%)      1 (7%)       5 (42%)                                            
      Mediastinal, Hyperplasia, Histiocytic            1 (7%)                                                                       
      Mediastinal, Pigmentation                        2 (14%)      3 (20%)      3 (25%)                                            
      Pancreatic, Hemorrhage                                        1 (7%)       3 (25%)                                            
      Pancreatic, Hyperplasia, Lymphoid                1 (7%)                                                                       
      Pancreatic, Pigmentation                         1 (7%)                    1 (8%)                                             
      Renal, Hemorrhage                                             1 (7%)                                                          
      Renal, Pigmentation                                           1 (7%)                                                          
   Lymph Node, Mandibular                             (60)         (59)         (60)         (59)                                   
      Ectasia                                          4 (7%)       5 (8%)       8 (13%)      2 (3%)                                
      Hemorrhage                                       1 (2%)       2 (3%)       3 (5%)       2 (3%)                                
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            3 (5%)       3 (5%)       1 (2%)       4 (7%)                                
      Hyperplasia, Plasma Cell                         7 (12%)      8 (14%)     10 (17%)     12 (20%)                               
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Pigmentation                                     3 (5%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (59)         (60)         (60)                                   
      Ectasia                                          1 (2%)                                 1 (2%)                                
      Hemorrhage                                       3 (5%)       3 (5%)       8 (13%)      3 (5%)                                
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (3%)       5 (8%)       2 (3%)                                             
      Hyperplasia, Plasma Cell                         2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Mast Cell                              1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Developmental Malformation                       1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis                                         4 (7%)       5 (8%)       3 (5%)       5 (8%)                                
      Hematopoietic Cell Proliferation                19 (32%)     19 (32%)     17 (28%)     16 (27%)                               
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Necrosis                                         2 (3%)                                                                       
      Pigmentation                                    44 (73%)     42 (70%)     42 (70%)     44 (73%)                               
      Lymphoid Follicle, Atrophy                       1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Red Pulp, Atrophy                                                          1 (2%)       2 (3%)                                
   Thymus                                             (58)         (57)         (59)         (58)                                   
      Congestion                                       1 (2%)       1 (2%)       2 (3%)                                             
      Cyst                                             1 (2%)       1 (2%)                    1 (2%)                                
      Ectopic Parathyroid Gland                                                               1 (2%)                                
      Hemorrhage                                                                 2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (59)         (60)         (60)                                   
      Hyperplasia, Cystic                             41 (68%)     47 (80%)     45 (75%)     51 (85%)                               
      Hyperplasia, Lobular                             5 (8%)       7 (12%)      5 (8%)       6 (10%)                               
   Skin                                               (60)         (60)         (59)         (60)                                   
      Acanthosis                                       3 (5%)                                 4 (7%)                                
      Exudate                                          2 (3%)                                 1 (2%)                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Ulcer                                                                                   2 (3%)                                
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Developmental Malformation                                    1 (2%)                                                          
      Fibrous Osteodystrophy                                        1 (2%)       4 (7%)       5 (8%)                                
      Calvarium, Osteopetrosis                        20 (33%)      9 (15%)     11 (18%)     10 (17%)                               
      Femur, Osteopetrosis                            12 (20%)      7 (12%)      4 (7%)       8 (13%)                               
      Sternum, Osteopetrosis                          12 (20%)      8 (13%)      4 (7%)       8 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                     16 (27%)     13 (22%)     12 (20%)     10 (17%)                               
      Developmental Malformation                       1 (2%)       1 (2%)                    1 (2%)                                
      Hemorrhage                                                                              2 (3%)                                
      Hydrocephalus                                    3 (5%)       6 (10%)      1 (2%)       4 (7%)                                
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
   Spinal Cord                                                                  (1)                                                 
      Hemorrhage                                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)       4 (7%)       4 (7%)       1 (2%)                                
      Edema                                                         3 (5%)                                                          
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       2 (3%)       2 (3%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               24 (40%)     19 (32%)     22 (37%)     17 (28%)                               
      Inflammation, Subacute                           1 (2%)       3 (5%)       2 (3%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Leukocytosis                                                               1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 4 (7%)       2 (3%)       4 (7%)       2 (3%)                                
      Bronchiole, Epithelium, Hyperplasia                                        1 (2%)                                             
   Nose                                               (60)         (60)         (60)         (60)                                   
      Exudate                                          7 (12%)     11 (18%)     15 (25%)     15 (25%)                               
      Foreign Body                                     3 (5%)       3 (5%)       5 (8%)       7 (12%)                               
      Fungus                                           4 (7%)       2 (3%)       5 (8%)       9 (15%)                               
      Glands, Hyperplasia                              1 (2%)       1 (2%)                                                          
      Mucosa, Hyperplasia                              7 (12%)      4 (7%)       8 (13%)      8 (13%)                               
      Mucosa, Metaplasia, Squamous                     4 (7%)       3 (5%)       4 (7%)       7 (12%)                               
      Mucosa, Necrosis                                                           1 (2%)       2 (3%)                                
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Mucosa, Hyperplasia                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (5)          (5)          (5)                                    
      Cataract                                         2 (100%)     4 (80%)      5 (100%)     4 (80%)                               
      Hemorrhage                                                                              1 (20%)                               
      Retina, Atrophy                                  2 (100%)     4 (80%)      5 (100%)     4 (80%)                               
   Lacrimal Gland                                                               (1)                                                 
      Ectopic Harderian                                                          1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Inflammation, Suppurative                        2 (3%)       3 (5%)      13 (22%)     17 (28%)                               
      Mineralization                                  59 (98%)     60 (100%)    60 (100%)    60 (100%)                              
      Nephropathy                                     58 (97%)     57 (95%)     58 (97%)     60 (100%)                              
      Interstitial Tissue, Pigmentation                1 (2%)       1 (2%)                    1 (2%)                                
      Renal Tubule, Cytoplasmic Alteration             5 (8%)       4 (7%)       3 (5%)       4 (7%)                                
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
      Renal Tubule, Pigmentation                      10 (17%)     12 (20%)      6 (10%)      5 (8%)                                
      Transitional Epithelium, Hyperplasia                                       3 (5%)      17 (28%)                               
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Dilatation                                                                 2 (3%)                                             
      Hemorrhage                                                                 2 (3%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Mucosa, Hyperplasia                              1 (2%)       1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                31           35           41           46                                     
    Natural Death                                      9            9            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            6            4            1                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (59)         (60)         (60)                                   
      Parasite Metazoan                                5 (8%)       4 (7%)       4 (7%)       5 (8%)                                
   Intestine Large, Rectum                            (59)         (58)         (59)         (60)                                   
      Parasite Metazoan                                6 (10%)      7 (12%)      6 (10%)      6 (10%)                               
   Intestine Large, Cecum                             (60)         (59)         (60)         (60)                                   
      Dilatation                                       1 (2%)       1 (2%)                    1 (2%)                                
      Edema                                            1 (2%)                                 1 (2%)                                
      Erosion                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Parasite Metazoan                                2 (3%)                                 1 (2%)                                
   Intestine Small, Duodenum                          (58)         (53)         (55)         (60)                                   
      Ectopic Tissue                                                             1 (2%)                                             
      Erosion                                          2 (3%)       3 (6%)       8 (15%)      4 (7%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
      Mucosa, Hyperplasia, Diffuse                                  1 (2%)                    2 (3%)                                
   Intestine Small, Jejunum                           (60)         (57)         (60)         (60)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Subacute                                        1 (2%)                                                          
      Mucosa, Hyperplasia, Diffuse                     3 (5%)       3 (5%)       4 (7%)       1 (2%)                                
   Intestine Small, Ileum                             (60)         (58)         (59)         (60)                                   
      Dilatation                                       1 (2%)                                 1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Subacute                                        1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mucosa, Hyperplasia, Diffuse                                  1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                      3 (5%)       2 (3%)       6 (10%)      4 (7%)                                
      Basophilic Focus                                13 (22%)     19 (32%)     24 (40%)     18 (30%)                               
      Clear Cell Focus                                 6 (10%)      4 (7%)       3 (5%)       5 (8%)                                
      Congestion                                       1 (2%)       2 (3%)       2 (3%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Degeneration, Cystic                            11 (18%)      8 (13%)      8 (13%)      6 (10%)                               
      Eosinophilic Focus                               2 (3%)       3 (5%)                    3 (5%)                                
      Granuloma                                        3 (5%)       3 (5%)       6 (10%)      2 (3%)                                
      Hematopoietic Cell Proliferation                 3 (5%)       3 (5%)                    2 (3%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hepatodiaphragmatic Nodule                      10 (17%)      8 (13%)      6 (10%)      3 (5%)                                
      Hyperplasia, Focal                               9 (15%)      7 (12%)      4 (7%)       6 (10%)                               
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Inflammation, Subacute                           1 (2%)       3 (5%)       4 (7%)       4 (7%)                                
      Mixed Cell Focus                                 6 (10%)      3 (5%)       3 (5%)       3 (5%)                                
      Thrombosis                                                    1 (2%)                                                          
      Bile Duct, Cyst                                  1 (2%)                    1 (2%)       1 (2%)                                
      Bile Duct, Hyperplasia                          48 (80%)     49 (82%)     47 (78%)     55 (92%)                               
      Centrilobular, Atrophy                           9 (15%)     12 (20%)      7 (12%)     16 (27%)                               
      Centrilobular, Necrosis                                       1 (2%)       2 (3%)       2 (3%)                                
      Hepatocyte, Vacuolization Cytoplasmic           16 (27%)     14 (23%)     13 (22%)      4 (7%)                                
      Kupffer Cell, Pigmentation                       3 (5%)       8 (13%)      4 (7%)       2 (3%)                                
      Lobules, Necrosis                                4 (7%)       7 (12%)      3 (5%)       1 (2%)                                
   Mesentery                                          (5)          (7)          (9)          (3)                                    
      Accessory Spleen                                                           1 (11%)      1 (33%)                               
      Hemorrhage                                                    1 (14%)                                                         
      Fat, Hemorrhage                                  1 (20%)                                                                      
      Fat, Necrosis                                    5 (100%)     5 (71%)      4 (44%)      1 (33%)                               
   Pancreas                                           (60)         (59)         (60)         (60)                                   
      Atrophy                                         34 (57%)     37 (63%)     33 (55%)     25 (42%)                               
      Cyst                                             1 (2%)                                 3 (5%)                                
      Fibrosis                                         1 (2%)                                                                       
      Focal Cellular Change                            1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
      Acinar Cell, Cytoplasmic Alteration              8 (13%)     11 (19%)     13 (22%)     11 (18%)                               
      Acinar Cell, Hyperplasia, Focal                 10 (17%)      5 (8%)       7 (12%)      1 (2%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Atrophy                                          2 (3%)       2 (3%)       2 (3%)       2 (3%)                                
      Acinar Cell, Cytoplasmic Alteration              5 (8%)       5 (8%)       4 (7%)       4 (7%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Edema                                            4 (7%)       7 (12%)      4 (7%)       2 (3%)                                
      Erosion                                          2 (3%)       1 (2%)       1 (2%)       2 (3%)                                
      Fibrosis                                                      3 (5%)       1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Subacute                           2 (3%)       1 (2%)                    1 (2%)                                
      Perforation                                                   1 (2%)                                                          
      Ulcer                                            7 (12%)     14 (23%)      9 (15%)      3 (5%)                                
      Mucosa, Hyperplasia                             12 (20%)     16 (27%)     10 (17%)      7 (12%)                               
   Stomach, Glandular                                 (60)         (59)         (60)         (60)                                   
      Cyst Epithelial Inclusion                        1 (2%)       1 (2%)                                                          
      Edema                                            6 (10%)      2 (3%)       5 (8%)       3 (5%)                                
      Erosion                                         11 (18%)      5 (8%)       6 (10%)      6 (10%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                            1 (2%)       3 (5%)                                                          
      Mineralization                                   4 (7%)       3 (5%)       2 (3%)       2 (3%)                                
      Ulcer                                            2 (3%)       3 (5%)       7 (12%)      2 (3%)                                
      Epithelium, Dilatation                                        2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (6)          (3)          (1)          (1)                                    
      Hypertrophy                                      2 (33%)                                1 (100%)                              
      Inflammation, Chronic Active                     6 (100%)     3 (100%)     1 (100%)     1 (100%)                              
      Thrombosis                                                                              1 (100%)                              
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  26 (43%)     30 (50%)     29 (48%)     28 (47%)                               
      Thrombosis                                       1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Myocardium, Inflammation, Chronic                                                       1 (2%)                                
      Myocardium, Mineralization                       1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Accessory Adrenal Cortical Nodule               14 (23%)     17 (28%)     15 (25%)     14 (23%)                               
      Atrophy                                          1 (2%)                                                                       
      Basophilic Focus                                              2 (3%)                    1 (2%)                                
      Congestion                                       1 (2%)       1 (2%)                                                          
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Diffuse                             1 (2%)                                                                       
      Hyperplasia, Focal                               6 (10%)      5 (8%)       7 (12%)      4 (7%)                                
      Hypertrophy, Focal                               4 (7%)       1 (2%)       2 (3%)                                             
      Necrosis                                                                                1 (2%)                                
      Pigmentation                                     3 (5%)       3 (5%)       1 (2%)       2 (3%)                                
      Vacuolization Cytoplasmic, Diffuse               6 (10%)      6 (10%)      4 (7%)       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                16 (27%)      9 (15%)     17 (28%)     15 (25%)                               
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hyperplasia                                     22 (37%)     21 (35%)     23 (38%)     15 (25%)                               
   Islets, Pancreatic                                 (60)         (59)         (59)         (59)                                   
      Hyperplasia                                      5 (8%)       2 (3%)       3 (5%)       4 (7%)                                
   Parathyroid Gland                                  (60)         (56)         (59)         (58)                                   
      Hyperplasia                                      8 (13%)      9 (16%)     13 (22%)      6 (10%)                               
   Pituitary Gland                                    (59)         (60)         (59)         (58)                                   
      Inflammation, Suppurative                                     1 (2%)                                                          
      Pigmentation                                                                            2 (3%)                                
      Pars Distalis, Angiectasis                       2 (3%)       1 (2%)       3 (5%)       4 (7%)                                
      Pars Distalis, Cyst                              4 (7%)       4 (7%)       2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia                       9 (15%)      7 (12%)      9 (15%)     13 (22%)                               
      Pars Distalis, Necrosis                                       1 (2%)                                                          
      Pars Intermedia, Angiectasis                     1 (2%)       1 (2%)                                                          
      Pars Intermedia, Cyst                            2 (3%)       2 (3%)       1 (2%)       3 (5%)                                
      Pars Nervosa, Hyperplasia                        4 (7%)       4 (7%)       4 (7%)      11 (19%)                               
   Thyroid Gland                                      (60)         (59)         (60)         (60)                                   
      Degeneration, Cystic                             4 (7%)       1 (2%)                    3 (5%)                                
      Hypoplasia                                                                              1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (2%)                                             
      Ultimobranchial Cyst                                          2 (3%)       1 (2%)       2 (3%)                                
      C-Cell, Hyperplasia                             11 (18%)      9 (15%)      2 (3%)       3 (5%)                                
      Follicle, Cyst                                   7 (12%)      2 (3%)       6 (10%)      7 (12%)                               
      Follicular Cell, Hyperplasia                     4 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Atypia Cellular                                 15 (25%)      9 (15%)     11 (18%)     10 (17%)                               
      Hypospermia                                     26 (43%)     22 (37%)     19 (32%)     23 (38%)                               
   Penis                                                           (2)          (1)                                                 
      Edema                                                         1 (50%)                                                         
      Inflammation, Suppurative                                     2 (100%)     1 (100%)                                           
   Preputial Gland                                    (60)         (60)         (60)         (59)                                   
      Ectasia                                          2 (3%)       3 (5%)       1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                           23 (38%)     26 (43%)     23 (38%)     27 (46%)                               
      Inflammation, Suppurative                        7 (12%)      5 (8%)       5 (8%)       6 (10%)                               
      Necrosis                                                      1 (2%)                                                          
   Prostate                                           (60)         (60)         (60)         (60)                                   
      Corpora Amylacea                                 7 (12%)      7 (12%)      9 (15%)      7 (12%)                               
      Ectasia                                          4 (7%)       1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis                                         3 (5%)       4 (7%)       3 (5%)       3 (5%)                                
      Hyperplasia, Lymphoid                           11 (18%)      8 (13%)      9 (15%)      8 (13%)                               
      Inflammation, Suppurative                       52 (87%)     48 (80%)     46 (77%)     37 (62%)                               
      Epithelium, Hyperplasia                          2 (3%)                    2 (3%)       2 (3%)                                
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
      Depletion Cellular                                                                      1 (2%)                                
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       1 (2%)                                
   Testes                                             (60)         (60)         (60)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Mineralization                                   2 (3%)                    1 (2%)                                             
      Spermatocele                                     1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                  11 (18%)     20 (33%)     11 (18%)     20 (33%)                               
      Seminiferous Tubule, Atrophy                    14 (23%)     18 (30%)     10 (17%)     13 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)                                                                       
      Hypercellularity                                              1 (2%)       4 (7%)       2 (3%)                                
      Myelofibrosis                                    4 (7%)       4 (7%)       2 (3%)       4 (7%)                                
   Lymph Node                                         (19)         (11)         (15)         (20)                                   
      Inguinal, Hyperplasia, Plasma Cell                                                      1 (5%)                                
      Lumbar, Hyperplasia, Plasma Cell                              1 (9%)                                                          
      Mediastinal, Hemorrhage                          3 (16%)      1 (9%)       3 (20%)      2 (10%)                               
      Mediastinal, Hyperplasia, Lymphoid                                                      1 (5%)                                
      Mediastinal, Hyperplasia, Plasma Cell            1 (5%)                    1 (7%)                                             
      Mediastinal, Necrosis                                                      1 (7%)                                             
      Mediastinal, Pigmentation                        1 (5%)                                                                       
      Pancreatic, Ectasia                              1 (5%)                                                                       
      Pancreatic, Hemorrhage                                                                  1 (5%)                                
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (5%)                                
      Pancreatic, Pigmentation                                      1 (9%)                                                          
      Renal, Hemorrhage                                1 (5%)       1 (9%)                                                          
      Renal, Hyperplasia, Plasma Cell                               1 (9%)                                                          
      Renal, Pigmentation                              1 (5%)                                                                       
   Lymph Node, Mandibular                             (60)         (58)         (59)         (60)                                   
      Congestion                                                                 1 (2%)                                             
      Ectasia                                          5 (8%)       9 (16%)      4 (7%)       7 (12%)                               
      Fibrosis                                                      1 (2%)                    1 (2%)                                
      Hemorrhage                                       4 (7%)       6 (10%)      2 (3%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       3 (5%)       8 (14%)      3 (5%)                                
      Hyperplasia, Plasma Cell                        15 (25%)     19 (33%)     11 (19%)     11 (18%)                               
      Inflammation, Suppurative                        1 (2%)                                                                       
   Lymph Node, Mesenteric                             (59)         (59)         (60)         (60)                                   
      Ectasia                                          1 (2%)       1 (2%)       2 (3%)                                             
      Hemorrhage                                       3 (5%)       4 (7%)       1 (2%)       5 (8%)                                
      Hyperplasia, Lymphoid                            2 (3%)       4 (7%)       6 (10%)      1 (2%)                                
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
      Pigmentation                                                  2 (3%)                                                          
   Spleen                                             (60)         (59)         (60)         (60)                                   
      Congestion                                                    1 (2%)                                                          
      Developmental Malformation                       2 (3%)       1 (2%)       1 (2%)                                             
      Fibrosis                                        11 (18%)     17 (29%)     14 (23%)     14 (23%)                               
      Hematopoietic Cell Proliferation                 9 (15%)     12 (20%)     12 (20%)     12 (20%)                               
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis                                         3 (5%)       2 (3%)       1 (2%)       1 (2%)                                
      Pigmentation                                    21 (35%)     35 (59%)     23 (38%)     25 (42%)                               
      Lymphoid Follicle, Atrophy                       2 (3%)       2 (3%)                                                          
      Red Pulp, Atrophy                                2 (3%)       1 (2%)                                                          
   Thymus                                             (54)         (59)         (57)         (56)                                   
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                                    3 (5%)                                
      Ectopic Parathyroid Gland                                                               1 (2%)                                
      Ectopic Thyroid                                               1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Epithelial Cell, Hyperplasia                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (58)         (57)         (56)                                   
      Hyperplasia, Cystic                             26 (48%)     30 (52%)     27 (47%)     16 (29%)                               
      Hyperplasia, Lobular                             2 (4%)       2 (3%)                                                          
   Skin                                               (60)         (60)         (59)         (60)                                   
      Acanthosis                                       4 (7%)       3 (5%)       2 (3%)       2 (3%)                                
      Cyst Epithelial Inclusion                        1 (2%)       1 (2%)       1 (2%)                                             
      Exudate                                          2 (3%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Fibrous Osteodystrophy                          10 (17%)     14 (23%)     16 (27%)     10 (17%)                               
      Hyperostosis                                                  2 (3%)                    1 (2%)                                
      Necrosis                                                      1 (2%)                    1 (2%)                                
      Femur, Osteopetrosis                             1 (2%)                                 1 (2%)                                
      Sternum, Osteopetrosis                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                     19 (32%)     18 (30%)     19 (32%)      6 (10%)                               
      Granuloma                                                                  1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Hydrocephalus                                    6 (10%)     10 (17%)     12 (20%)      5 (8%)                                
      Mineralization                                                1 (2%)                    2 (3%)                                
      Necrosis                                                                                3 (5%)                                
      Vacuolization Cytoplasmic                        1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       4 (7%)       1 (2%)       4 (7%)                                             
      Edema                                                         1 (2%)                                                          
      Foreign Body                                                  1 (2%)                    1 (2%)                                
      Hemorrhage                                                    2 (3%)       2 (3%)       2 (3%)                                
      Hyperplasia, Lymphoid                                         3 (5%)       2 (3%)                                             
      Infiltration Cellular, Histiocyte               15 (25%)     12 (20%)     12 (20%)     15 (25%)                               
      Inflammation, Subacute                           2 (3%)       5 (8%)       7 (12%)      2 (3%)                                
      Inflammation, Suppurative                                     2 (3%)                    1 (2%)                                
      Leukocytosis                                                               1 (2%)                                             
      Metaplasia, Osseous                              2 (3%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 6 (10%)      2 (3%)       6 (10%)      5 (8%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Exudate                                         30 (50%)     26 (43%)     34 (57%)     24 (40%)                               
      Foreign Body                                    16 (27%)     17 (28%)     18 (30%)     12 (20%)                               
      Fungus                                          17 (28%)     17 (28%)     22 (37%)     14 (23%)                               
      Mucosa, Hyperplasia                             25 (42%)     24 (40%)     24 (40%)     21 (35%)                               
      Mucosa, Metaplasia, Squamous                     6 (10%)      9 (15%)      9 (15%)      7 (12%)                               
      Mucosa, Necrosis                                              2 (3%)                    4 (7%)                                
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Mucosa, Hyperplasia                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (3)          (2)          (3)                                    
      Cataract                                         4 (100%)     3 (100%)     1 (50%)      3 (100%)                              
      Inflammation, Chronic                                         1 (33%)                                                         
      Retina, Atrophy                                  4 (100%)     3 (100%)                  3 (100%)                              
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Cyst                                                                                    1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hydronephrosis                                                1 (2%)                    1 (2%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Suppurative                       10 (17%)     18 (30%)     12 (20%)      9 (15%)                               
      Mineralization                                  27 (45%)     30 (50%)     40 (67%)     57 (95%)                               
      Nephropathy                                     59 (98%)     59 (98%)     60 (100%)    60 (100%)                              
      Thrombosis                                                                              1 (2%)                                
      Interstitial Tissue, Pigmentation                                                       1 (2%)                                
      Renal Tubule, Cytoplasmic Alteration                                       1 (2%)                                             
      Renal Tubule, Hyperplasia                        3 (5%)       7 (12%)      6 (10%)      6 (10%)                               
      Renal Tubule, Hyperplasia, Oncocytic                                       2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05142-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Pigmentation                       7 (12%)      9 (15%)      6 (10%)     12 (20%)                               
      Transitional Epithelium, Hyperplasia            25 (42%)     32 (53%)     36 (60%)     40 (67%)                               
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Angiectasis                                                                1 (2%)                                             
      Dilatation                                       2 (3%)                    2 (3%)       2 (3%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Subacute                                                     1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       2 (3%)                                                          
      Mucosa, Hyperplasia                                                        3 (5%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.