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TDMS Study 05142-03 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          T-BUTYL ALCOHOL


NTP Experiment-Test: 05142-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: DOSED WATER                                                                                                Time: 07:39:33




       Facility:  Southern Research Institute

       Chemical CAS #:  75-65-0

       Lock Date:  01/10/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            8            7            3                                     
    Moribund Sacrifice                                15           18           21           35                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           24           22           12                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (60)         (60)         (59)         (60)                                   
   Intestine Small, Jejunum                           (60)         (59)         (59)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Fibrosarcoma                                     1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                    1 (2%)                                
   Mesentery                                          (9)          (6)          (8)          (6)                                    
      Carcinoma, Metastatic, Uterus                                              1 (13%)                                            
      Sarcoma Stromal, Metastatic, Uterus                                        1 (13%)                                            
   Pancreas                                           (60)         (60)         (59)         (60)                                   
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
   Pharynx                                                                                   (1)                                    
      Squamous Cell Papilloma                                                                 1 (100%)                              
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Carcinoid Tumor Benign                                                     1 (2%)                                             
   Tongue                                                          (1)          (1)          (3)                                    
      Squamous Cell Carcinoma                                                    1 (100%)                                           
      Squamous Cell Papilloma                                       1 (100%)                  1 (33%)                               
   Tooth                                                           (2)                                                              
      Gingiva, Squamous Cell Carcinoma                              1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)       1 (2%)                    1 (2%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (59)                                   
      Pheochromocytoma Malignant                                    1 (2%)                    1 (2%)                                
      Pheochromocytoma Complex                                                   1 (2%)                                             
      Pheochromocytoma Benign                          3 (5%)                    1 (2%)       2 (3%)                                
   Islets, Pancreatic                                 (60)         (60)         (58)         (60)                                   
      Adenoma                                          1 (2%)       1 (2%)       4 (7%)       1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (60)         (60)         (59)         (59)                                   
      Pars Distalis, Adenoma                          33 (55%)     32 (53%)     28 (47%)     30 (51%)                               
      Pars Distalis, Carcinoma                         2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (59)         (60)         (60)         (60)                                   
      C-Cell, Adenoma                                  8 (14%)      4 (7%)       6 (10%)      9 (15%)                               
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (60)         (60)         (60)                                   
      Adenoma                                          4 (7%)       6 (10%)      4 (7%)       2 (3%)                                
      Carcinoma                                        3 (5%)       2 (3%)       6 (10%)      4 (7%)                                
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Granulosa-Theca Tumor Benign                     1 (2%)                                                                       
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                        1 (2%)                    1 (2%)                                             
      Carcinoma In Situ                                             1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Leiomyoma                                        1 (2%)       1 (2%)                                                          
      Polyp Stromal                                   14 (23%)      6 (10%)      9 (15%)      7 (12%)                               
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (14)         (15)         (12)         (7)                                    
   Lymph Node, Mandibular                             (60)         (59)         (60)         (59)                                   
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (60)         (59)         (60)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
   Thymus                                             (58)         (57)         (59)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (59)         (60)         (60)                                   
      Adenoma                                          2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Carcinoma                                        6 (10%)      5 (8%)       1 (2%)       1 (2%)                                
      Fibroadenoma                                    14 (23%)     15 (25%)     11 (18%)      8 (13%)                               
   Skin                                               (60)         (60)         (59)         (60)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Keratoacanthoma                                                            1 (2%)                                             
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                                  1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                2 (3%)       3 (5%)                                                          
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                                 (1)          (1)          (1)                                    
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Oligodendroglioma Malignant                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                                                            2 (3%)                                
      Alveolar/Bronchiolar Adenoma, Multiple, Two                                1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
                                                             Page   4                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Fibrosarcoma, Metastatic, Skin                   1 (2%)       1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (2)          (1)                       (1)                                    
      Carcinoma                                        2 (100%)     1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Sarcoma Stromal, Metastatic, Uterus                                        1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            22 (37%)     20 (33%)     19 (32%)     14 (23%)                               
      Mesothelioma Malignant                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.25%        0.50%        1.00%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            54          51          48          50                                       
     Total Primary Neoplasms                          130         108         108          92                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          45          40          39                                       
     Total Benign Neoplasms                            87          71          72          69                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          31          29          22                                       
     Total Malignant Neoplasms                         43          37          36          23                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           2           1                                       
     Total Metastatic Neoplasm                          3           4           5           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                31           35           41           46                                     
    Natural Death                                      9            9            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            6            4            1                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (59)         (60)         (60)                                   
   Intestine Large, Rectum                            (59)         (58)         (59)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Liver                                                  1 (2%)                                
   Intestine Large, Cecum                             (60)         (59)         (60)         (60)                                   
   Intestine Small, Duodenum                          (58)         (53)         (55)         (60)                                   
   Intestine Small, Jejunum                           (60)         (57)         (60)         (60)                                   
   Intestine Small, Ileum                             (60)         (58)         (59)         (60)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Mesentery                                          (5)          (7)          (9)          (3)                                    
      Carcinoma, Metastatic, Pancreas                                            1 (11%)                                            
      Fibrosarcoma, Metastatic, Skin                                                          1 (33%)                               
      Hemangiosarcoma                                                            1 (11%)                                            
   Pancreas                                           (60)         (59)         (60)         (60)                                   
      Carcinoma                                                     1 (2%)       1 (2%)                                             
      Acinar Cell, Adenoma                             3 (5%)       6 (10%)      1 (2%)       1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (60)         (59)         (60)         (60)                                   
   Tongue                                             (1)                                    (1)                                    
      Squamous Cell Papilloma                          1 (100%)                               1 (100%)                              
   Tooth                                                                                     (1)                                    
      Fibrosarcoma                                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Schwannoma Benign                                1 (2%)                                                                       
      Thymoma Malignant, Metastatic, Thymus                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Ganglioneuroma                                                             1 (2%)                                             
      Pheochromocytoma Malignant                       4 (7%)       1 (2%)       2 (3%)                                             
      Pheochromocytoma Benign                          9 (15%)      6 (10%)      4 (7%)       4 (7%)                                
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (59)         (59)         (59)                                   
      Adenoma                                         15 (25%)     15 (25%)      7 (12%)      6 (10%)                               
      Carcinoma                                        2 (3%)                    2 (3%)                                             
      Histiocytic Sarcoma, Metastatic, Liver                                                  1 (2%)                                
   Pituitary Gland                                    (59)         (60)         (59)         (58)                                   
      Pars Distalis, Adenoma                          39 (66%)     38 (63%)     35 (59%)     27 (47%)                               
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (60)         (59)         (60)         (60)                                   
      C-Cell, Adenoma                                  5 (8%)       5 (8%)       1 (2%)       5 (8%)                                
      C-Cell, Carcinoma                                1 (2%)       2 (3%)                    1 (2%)                                
      Follicular Cell, Adenoma                         2 (3%)                                                                       
      Follicular Cell, Carcinoma                       2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)          (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Liver                                                  1 (2%)                                
   Preputial Gland                                    (60)         (60)         (60)         (59)                                   
      Adenoma                                          2 (3%)       1 (2%)       1 (2%)       2 (3%)                                
      Carcinoma                                        1 (2%)       3 (5%)       3 (5%)       1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
                                                             Page   8                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Prostate                                           (60)         (60)         (60)         (60)                                   
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
   Testes                                             (60)         (60)         (60)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           23 (38%)     17 (28%)     19 (32%)     24 (40%)                               
      Interstitial Cell, Adenoma                      15 (25%)     17 (28%)     20 (33%)     16 (27%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (19)         (11)         (15)         (20)                                   
      Mediastinal, Carcinoma, Metastatic, Pancreas                               1 (7%)                                             
      Pancreatic, Carcinoma, Metastatic, Islets,                                                                                    
           Pancreatic                                                            1 (7%)                                             
   Lymph Node, Mandibular                             (60)         (58)         (59)         (60)                                   
   Lymph Node, Mesenteric                             (59)         (59)         (60)         (60)                                   
   Spleen                                             (60)         (59)         (60)         (60)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
   Thymus                                             (54)         (59)         (57)         (56)                                   
      Thymoma Benign                                   1 (2%)                                 2 (4%)                                
      Thymoma Malignant                                             1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (58)         (57)         (56)                                   
      Fibroadenoma                                     1 (2%)       2 (3%)       1 (2%)                                             
   Skin                                               (60)         (60)         (59)         (60)                                   
      Basal Cell Adenoma                                                         2 (3%)                                             
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Keratoacanthoma                                               2 (3%)       2 (3%)       1 (2%)                                
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                          3 (5%)       3 (5%)       2 (3%)       1 (2%)                                
      Sebaceous Gland, Adenoma                                                   1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       3 (5%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Chordoma                                         1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Carcinoma, Metastatic, Pancreas                                            1 (100%)                                           
      Chordoma, Metastatic, Bone                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Oligodendroglioma Benign                                                                1 (2%)                                
   Spinal Cord                                        (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Carcinoma, Metastatic, Preputial Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)       1 (2%)                    1 (2%)                                
      Chordoma, Metastatic, Bone                       1 (2%)                                                                       
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Thymoma Malignant, Metastatic, Thymus                                                   1 (2%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)          (1)                                    
      Carcinoma                                                                  1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Bilateral, Renal Tubule, Adenoma, Multiple                                              1 (2%)                                
      Renal Tubule, Adenoma                            1 (2%)       3 (5%)       4 (7%)       2 (3%)                                
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
      Renal Tubule, Oncocytoma Benign                  1 (2%)                                                                       
      Transitional Epithelium, Papilloma                                         1 (2%)                                             
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma, Metastatic, Liver                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            30 (50%)     28 (47%)     24 (40%)     25 (42%)                               
      Lymphoma Malignant Mixed                                                   1 (2%)                                             
      Mesothelioma Benign                                                        1 (2%)                                             
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Mesothelioma Malignant                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page  11                                                               
NTP Experiment-Test: 05142-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95  
Route: DOSED WATER                                                                                                Time: 07:39:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.125%       0.25%        0.50%                                     
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            59          57          59          59                                       
     Total Primary Neoplasms                          170         159         143         131                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 57          55          58          56                                       
     Total Benign Neoplasms                           126         120         106          96                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38          33          32          30                                       
     Total Malignant Neoplasms                         44          39          37          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           3           4                                       
     Total Metastatic Neoplasm                          6           1          12          11                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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